(data stored in ACNUC7421 zone)

SWISSPROT: B1VNT4_STRGG

ID   B1VNT4_STRGG            Unreviewed;      4185 AA.
AC   B1VNT4;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   30-AUG-2017, entry version 72.
DE   SubName: Full=Putative NRPS-type-I PKS fusion protein {ECO:0000313|EMBL:BAG17107.1};
GN   OrderedLocusNames=SGR_278 {ECO:0000313|EMBL:BAG17107.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17107.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17107.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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DR   EMBL; AP009493; BAG17107.1; -; Genomic_DNA.
DR   ProteinModelPortal; B1VNT4; -.
DR   STRING; 455632.SGR_278; -.
DR   EnsemblBacteria; BAG17107; BAG17107; SGR_278.
DR   KEGG; sgr:SGR_278; -.
DR   eggNOG; ENOG4105C0W; Bacteria.
DR   eggNOG; COG0318; LUCA.
DR   eggNOG; COG1020; LUCA.
DR   eggNOG; COG3321; LUCA.
DR   HOGENOM; HOG000024085; -.
DR   OMA; PITHRSM; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR032821; KAsynt_C_assoc.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00501; AMP-binding; 2.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 3.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 3.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 3.
DR   SUPFAM; SSF47336; SSF47336; 4.
DR   SUPFAM; SSF51735; SSF51735; 3.
DR   SUPFAM; SSF52151; SSF52151; 2.
DR   SUPFAM; SSF53901; SSF53901; 3.
DR   SUPFAM; SSF55048; SSF55048; 1.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 1.
DR   PROSITE; PS50075; ACP_DOMAIN; 3.
DR   PROSITE; PS00455; AMP_BINDING; 2.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
DR   PRODOM; B1VNT4.
DR   SWISS-2DPAGE; B1VNT4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685}.
FT   DOMAIN      586    655       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     2123   2192       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     3225   3292       Carrier. {ECO:0000259|PROSITE:PS50075}.
SQ   SEQUENCE   4185 AA;  434329 MW;  D9671AF66C02DCD7 CRC64;
     MEHDMTLLDV LLDAVREAPG QVVVHVRGDG GELTVSLSEL LDESLRVAGG LRAAGVAPGT
     CVPLLADRSE DFQPMFWGAV AAGLVPVPLA PDARRVLPVW EHLGRPPVVV DASTASLSGE
     LPDDVRALSL DVLREGPALR EPVAAGRDDV AFVQFSSGST GAPKGVEVTH GAVLANLEQI
     RAASELGPED VVVSWMPYFH DMGLIGTHLA PLAARARQVK IGPLSFAKRP RLWFEVAARH
     RATVLSAANF ALALAVRRVP EEVLARLDLS AVRLVLVGAE PIAPAVWRAF ADRTRPSGLA
     PAAAQPVYGL AEATLAVTFP PPGEVAEPLV LDRASLSRGV AVDAEPGDEA VELMDVGRPV
     AGCAVRIVDD AGTVLGDRRT GHIMVSGPQL ARGYHGLPDV SAEVFAGGWL RTGDTGFLRD
     GRLCVTGRHK DVLFLNGRTF HATDLEEVAA ATPGLPSGAP AVVGSTDPVT GAERVVVFVP
     WARPAREASE VLERVAARVR EALLHDDVRV LALPPGAFPR TTSGKLQRRR LRERFEEGVF
     GSGERRAGEP GAGEVAAGAA GGPPFTEPGR PAAEPRALAP RTRAETVEVV REAWARVLGR
     PADAIGTHEP FGSIGGTSLK AMEMLVALED AFGVTLPPAV ARDHDTVAAL AGHLLTVAPG
     PVLPLADSAK ASDTSETSES VVRRTGGTVG GRAPALPDPA DAATAVIGMA CRFPGADTPE
     AFWDLLVDGH DAVAPVSRGR WDDGHAAPGA RTAVPGVAGV PGVPRERWAA LLEDPAAFDA
     DFFGIGEDEA RTLDPQARIF LELAHEALER AGYAGPRRHG HRIGVFAAVG DSGYREVLER
     ARAEGAPLPA ALTGNLPSLV AARVSQCLDL DGPALAVDTA CSSGLVALHL ARRSLLDGEC
     DLAVVGGVNL HLTSAPHRLL EEAGALSPTG RSRAFSSDAD GFVPGEGGAA IVLTRLDAAR
     RADDPVLAVV RGTAVNNDGR SMSLMAPNPL RQREVITRAY EAAGVDPAAV TYVEAHGTGT
     AVGDPIELRS LAHAFPQRPG GEPRLVGSVK TNIGHLLNAA ALPSLVKVVL ALGHRRLPPS
     LHHTPASPGL APAGFSVVTK ARDWTSTGPL LAGINAFGFG GTNAHAVLEQ APPPAAPASP
     PTGEAREVSV EGPHLLTLSA HSPGALRDAV TRLATHLESR PLLREGDVCR TASTSRDEGP
     HRLAVIAHGD LRERLAAVSA AGTGEAGGRG GSPVRSRPRV VFLYPGQGSR FPGQDRALYR
     TARVFRDTFD EASALLGPVG GRSLLDWALD PEVDAAARDA TEQAQPLLVA SGVALSRQLR
     AWGVEPDAVA GHSVGELTAA CVSGVLTLRE AVSFAAERGR LMEAFTEPGA MIAVRGGEEA
     VAAAVAESDG ALTVAAYNGP GLQVLSGGVR AVESAAARLE GLGVPTRRVR VSRAFHSPLM
     RPVADRIAEA ARALTPRAPS VPLMSTVTAE WQPVLGPEYL RDHAERPVLF GAAVERLARE
     GYDTFVEVGH GATLSGAVRA ATGVAAPAGV GGAGASGAAG RPATVLCALP GRSESRADAE
     RRSSEDGHGG RGDLLATIGR LWSHGVPLDR TALDAEHRGI PLPTYPYQRR RYWADPPASP
     LLHRVLWEDS ALPGQTARAV RSVLLTGPDP AYVAGLASQL ADAGVRTHET GDGPPDAVVL
     VAGPAPGQDT ADALGRAQDT ALAAFDEALA RFDETGADRL LVLTEDVHAT GAVRERPRPA
     HAVLGGLLMA LPQETSGASA TALDLCSLDT PSQRLAAVLA ELAEPAASSG PRGGAALVAR
     RAGRRLTRRF APLPSGAAAP AGPGRSPLPP DGTYLITGGG GGIGASLARD LAGRGRPTLV
     LAGRSPGLPE GLSEELRALG ATVDYRMADV SVEQDVEALL AGLGHLDGLF HAAGAVRPGT
     LRDRRAEETA EALAAKTRGT LLLSLALRRH GLDPAVRVVF SSVSAVLPGL AGALGDYAGA
     NAFLDAFAAS ERHAGRPWQS VNLAAVAGTG MAAALGTGAW PATGGGPAAG ASAGGRPVAL
     RPALAALRTA CGVDAAQLLL ADLTPFREPT VMTDRTAPAA VAGPGDSPAS GTDSSGTVSG
     TAQPPGAGPR TGSGPRGDTA GGTAALLRRL LASALRLPDA AVPDDEPFLA LGLDSLAAVD
     LVRQLERELG RTLPATLFFE YRTVAELAAH LDTTPSLLRS PASAPPAVPD GVAFPLTPVQ
     LALHTSSRLH PDVPAHGYVR QTVRGPLDTG LLGRALTALA DRHAMLRIRV QQTGSLGSGD
     DGISGGTGSA TPGQYVAPPA PLSAWYEVRE PAGRIEEVET ALCNRPFDLS AEPPVRALLA
     RESPELSHLV LVIHHAAGDG YSLNVLAGEL WSLYTSLAEG QAPTLPALAT DFARYAVATA
     EARSATDGTR ALAADRLYWS GRLAARGEPL RLPYDGDPSA LPAAPVNTHQ SALGPVPTAA
     LERRAAAHGV SLFHLLLAVH VRCLARWSGQ REIAVNVARA RRDDRMAGLD RLVGPLADTL
     PLLCATDPDE PVETLAERLA GIWLESERHA SLTGLDLARL LPTDPSGAGP RTVSPAGFSF
     SRFPAALDGR CPVSVRPTAA GTATAATRLS LLCWQDEAVL RFSWNFPARL FAPATVARLD
     RDFHAELTAL VEPRPGLPAV PGPVQVPAPG TGSATLVRRL VERFRATPDA VAVDTGATTL
     TYAELDRASH ALAASLLARG VTGGSLVGLL TEPGADTVVA VVAVLRAGAG WVPLDPGHPA
     ARLTDQLTRS GARTVVCHAA TRAVGEALGD VALVVADVSA LAYRGAGVPG SVPGPDRVAG
     TLRSPEAAPA PDGPADADAI AYVIFTSGST GRPKAVPITH RSMENYLDWA IGTFGYDEHD
     RLAQTASPCF DASVRQLLAP LLVGATVVTV AWDLLRDPDR LLTHVVRGRI TVWSSVPTLW
     EQLLSASEER VRNGAPPPDL SALRWIHVGG EALSPAHVRR WFDLFGDGQH IANLYGPTEA
     TINTSCHIIR ARPGDQVRRL PIGRPVAGTE VEVVGPDGEP AGPGEAGELL ISGVGLTPGY
     LGEPALTEAA FTVRRGRRWY RSGDRVRCSE DGVLEFLGRL DDQVKIRGNR VEPGEIEAVL
     QTHPDVAHAV VLAGDGRLTA FVTPGPGAAG ADAAGLRLHL AQSLPAYMLP SRITRVDRMP
     LTGTGKIDRR ALPALQEAAA PPGADTNAGP AARTGDVRTP PRTPTEVRLA AIWTALLQTD
     DVSREDDFFV LGGDSLLVLE VFARLEKQGG PLPRPTVVYR NRTLAALAAA VDVAAGAAAE
     SGEPTGVAAR AAADPSAGEP GAGDDRTGAP DPSVTPLPFP LTPTQRGFLL AEAIAPGATS
     SWLTRLRLHG RLDTARFQSA VDTLVERHPM LRTVFPAGAR PAVQQELPSS LRLPVDFEVL
     TDPAQVEERV TAERARRFEP WAWPLMRLRV LTTAPDEHVL VAHAHHIIGD GYSAALLVRE
     LTAVYDALSR GEEPASGRPR STFRDHALHL AARTDARTAP PAATASGTTA GRDSVAPAKS
     PRQGVPAVQD RWERLNAPYA QPRLAAGTTT AGAPRDAVAP LFHTCGFTVE ADRVEALRGL
     AARTGSTLHA PVLTAYYRAL VSATGRADLV LGMAVSGRDH ALPDAHRVFG PFATAVPLRP
     AGPASGRPGS ADFDDDLRRV AAEAAEARTY EGPVPPLSNG LPMTSQFFFT YLDFSALGPE
     VGRTLTVTRE GGDSVYTPPP AGTDVFLAAA PEGGRLRITV RAAATAFTPK ALAAFTDSVR
     DGLARAAAST AAEAGRPDRP ASGRDGRMDA ALVGYLPSPA DLARLAGLPE TALPREQLRT
     LLFPDGLPRL LETLRTPLGR SGFVCVPLFA DELAPGDDLL GHTTRGVELA SSLGARAVSL
     AGMIPSLTGY GFDVLRAVGT TEAVTTTGPA VTTGHAATVL SVVRTVHAAL DATGQRLGSL
     TVAFVGLGSI GSSSLELLLT RSQQPPARLL LCDVPGSGPR LKELAESLLE RGLVEVVEVV
     ESGHGLPDAV YDARLIVAAV SGGGALLDID RLAPGTTVVD DSFPHCFDTS RAVGRMERSK
     DVLVVGGGLL SAGPAERQVA EGLPAAAVAG YLARPMVPDT IASCRLESLL HASGAGVPLV
     HGPVDAATGL AYWEAAEATG IRAAPLHLLT RTVDPDMFTR HPWSS
//

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