(data stored in ACNUC7421 zone)

SWISSPROT: B1VQH6_STRGG

ID   B1VQH6_STRGG            Unreviewed;      5152 AA.
AC   B1VQH6;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   30-AUG-2017, entry version 61.
DE   SubName: Full=Putative NRPS {ECO:0000313|EMBL:BAG17277.1};
GN   OrderedLocusNames=SGR_448 {ECO:0000313|EMBL:BAG17277.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17277.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17277.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00258}.
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DR   EMBL; AP009493; BAG17277.1; -; Genomic_DNA.
DR   RefSeq; WP_012377802.1; NC_010572.1.
DR   ProteinModelPortal; B1VQH6; -.
DR   STRING; 455632.SGR_448; -.
DR   EnsemblBacteria; BAG17277; BAG17277; SGR_448.
DR   GeneID; 6211169; -.
DR   KEGG; sgr:SGR_448; -.
DR   PATRIC; fig|455632.4.peg.425; -.
DR   eggNOG; ENOG410XPD8; LUCA.
DR   HOGENOM; HOG000229991; -.
DR   OMA; LVFGRCA; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.1220.10; -; 2.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR013321; Arc_rbn_hlx_hlx.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF13193; AMP-binding_C; 4.
DR   Pfam; PF00668; Condensation; 6.
DR   Pfam; PF00550; PP-binding; 4.
DR   SMART; SM00823; PKS_PP; 4.
DR   SUPFAM; SSF47336; SSF47336; 4.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 4.
DR   TIGRFAMs; TIGR01720; NRPS-para261; 2.
DR   PROSITE; PS50075; ACP_DOMAIN; 4.
DR   PROSITE; PS00455; AMP_BINDING; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE   4: Predicted;
DR   PRODOM; B1VQH6.
DR   SWISS-2DPAGE; B1VQH6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685}.
FT   DOMAIN      976   1042       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     2472   2539       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     3537   3603       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   DOMAIN     5078   5144       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   MOD_RES    1008   1008       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   5152 AA;  549429 MW;  2E720A817D21A113 CRC64;
     MTGAPQGLQD ILPLSPLQQG LYFLSSYDDS ALDVYNVQLG LDLTGPLDTD RLRRAVAALL
     DRHPNLKAAF RTRRNGDPVT VVPHTVDIPW QETDLSGVDA AERDRRVARL ADADRHTRFD
     LARPPLVRFT AIRLSAERHR LLFTHHHLLL DGWSTARVVQ ELFALYAADG STTALPEVRP
     YRDYLAWAAA QDTAADERAW RGALAGLDGP TVIAPGLDGQ PQAQPATRDV ELSPGSARAL
     AATARALDVT VPVVVQTLWS LVLADLTGRR DIVSGTTVSG RPAELAGADS MVGLFINTLP
     VRVRIRHDET LAELVRRTAG EQAALLAHHH VALARIQKLT ETGGPLFDTL CVFENYLVDS
     GPDDPEDARE KEFAGLRVEA VTGRDATHYP LTLVAAPGAD GGPLLRLSYR ADAIGGREAA
     RIAARLRRAV EEFTADPHRP LPRTDLLTPE ERDRVLNTFN ADTTDVEPAT LPELFERQAA
     AHPDRPAVEA AGRVLTYTEL NTRANRLAHA LIATGVGPED VVGVALRRGA DVHIAQLAVG
     KAGGVFAPLD PDQPAERLAG LIAGSGAAVV LAHSGTDHTP WSGDATVIAT DRLPEGLPGH
     DPTDADRRAP LRLHNGAYLI HTSGSTGRPK GVLVEHRPLV DLVTWAHARF ATRPGDRVTQ
     FASPSFDVTF AELANSLFAG ATLVVVPEEE RAGAPLADFL NRAAITLAVI PPTVVASLPL
     DASLPAGMSL VVGTEALPPE VVRAWADRHR LFNAYGPTEA VVNSATWEVP ARWAGGPVPI
     GPPDVNKRAY VLDDALRPVA PGVLGELYIG GPGLARGYLG RPLITADRFV ADPFGAPGTR
     MYRTGDLARW NERGELEYAG RTDHQLKIRG FRVEPGEVEA RLTAHPAIAQ AVVTGHTDGR
     GVRRLVAHAV PAPGGDPRPA DIVAWAAEGL PDHMVPAAVV LLDALPLTAA NKTDRSALPA
     PDFTATGAGT APRTDREKEL AALFADILHL PEVGVEESFF ALGGDSISAI QLVGAARRRG
     LRLSPRDVFE RRTVEQLASL ARTVDDTAPP VERTARSAPL TPVLRWLVER GGPIADYHQS
     TVLHTPAGAT AAQLTAGLGR VLDHHDVLRA RLTDRTLEIP APGESGPAPL TRIDAVETAD
     ADLLPSLRTG AREAARLLDP YTGTMVRAVW LDAGPDRGGL LALLIHHAVV DGVSWRILTQ
     DLAASLEAER HGRTVELPPV ETSFADWAQG LGQAALAPER VAEAAHWTAV LGDGGAVLPA
     PDPALDTLAT VTTVPVELAP EHTLPLLTDL PERFHTGPDT FLVTALALAL AAWRGDSEPV
     LVDIEGHGRA DQLVPDAELS RTVGWFTAVH PVRLDLGGLA APSGDGLTGA LKRVKEQLRA
     APDSGLGFGL LRHLNPDLRD RLAALPEPRV AYNYLGRFGA TGAAERTGAP APWSPALTGS
     LGGGADDALP APHTLTLNAS VVDGPQGPAL HAGFSFPGRL LETTGVERLA ALWTAALRDL
     ARLTAEPAAG GHTPGDFPLV EVDQPEIDAL EARGPLADLL PLSPLQAGLY FLSGFGAEGD
     GPDVYTTQTV LDIEGDLDAE RLRRAGRALL DRHPNLRAGF LGRRGADPLQ VVPAGGEIPV
     HAYDLTSPDL SEGRRQGRAQ NILAADRRQG FDLTAPPLLR LTLVRLGEHR HLLAVTSHHI
     LLDGWSGPLL VRDLLALYRG APGPAPRPYR DYLLWLNGRD RAATRGQWQE ALAGIDGPTR
     LVPEAAAMPA GTPERVDIPL PDDLVARVHA FARAHDVTVS TVLQGAWGLL LGRLTGRTDV
     TFGVTVSGRP ADLDGSHDMI GLFINTVPTR VTPRPDQTLA ALVRQLGQRQ ALLMDHQYEP
     LAELQRLAGH RELFDTLVLF ENFPVDAEQL RRTEEAAGLQ VTGARGHDAT HYPLVLVALP
     GRDRLALALD HRPELLTADR VATIGAQLVS VLEQLVDHPE STAATVLPAL AEPTRLDGPA
     RAVTPLGLAG RFLRRAAETP AATALIAGDE EWSYADLAAR VTAVAGRLRE LGARPERLIA
     VALPRSADLV AVLLAVSATG AAYVPVDPDF PADRVAHLLA DSDPLLVIRP GHPVLAPGPH
     GGTRAELPGA APDPESTAYV IHTSGSTGNP KGVVVTHGAL ANLLDAIAKT LGSGPGHRLL
     AVTTVSFDIA ALELFVPLVT GAAVVLAQRE EVLDPLLLSG LAERTRATHL QATPSLWRGI
     IDAAPGLLDG LCVLSGGEPL PADLADRLAR GGARLLNLYG PTETTIWSTA ADLAPDSGTP
     HVGHALRNTA LRVLDTWLRP VPPGVPGELY IGGAGLARGY LGRGALTASR FTADPFGAPG
     DRMYRTGDLA RIQDDGTLRV LGRTDHQLKV RGHRVEPGEI ETALRSHPEV TDTVVVGLPD
     PSGSVRLVAY VTGAATELRP YLAQRLPEHL VPSVVVRLPA LPLTPNGKVD RAALPAPQAS
     GGERTRAPRD AREAVLGELF ADVLGLDRAG PDDDFFHLGG HSLLAMQLAN RLRSTLGVDV
     ALRDIFEHPT PAALAGTVLP RPAARTAPVR RERRPGERIP LSFAQSRLWF LHRLDGPSAT
     YNLFIVVRLG GELDREALRL AVGDVVTRHE SLRTVYPDAD GLPHQHILDE ESARAACDRS
     FAEVAEVAEA DLAAALRARV TRPVDIIEEI PLRAQLLRTG NDHVLALTLH HIAGDEWSMR
     PLVDDLRTAY TARVTGADHA WEPLPVDYAD YALWQREALG ELTDPTSQVA RQAAFWERTL
     AGSPDELALP YDRPRPAEET HEGATVTFAV DPAVHADLRS LAARNGTSVF MAVQAALAVL
     LSAHGAGTDI PLGTPVAGRT DEKFDDLIGF FVNTLVLRTD LSGRPTFHEL LARVRDTDLA
     AFDHADLPFE QLVDIVAPER TLARNPLFQV MLVFQNVSGD DTFTLPGLDA TPVSADPGVA
     KLDLQFTLAE RPDGAGITGM LIYQTSLFDH TTAQALADRY VTLLAALVAR PELPVHRAAV
     LSPPQRAGVL AASTGDERPL PHAPLPRLLA ERYAAGATAP ALIDDGISLG YEEFDGRVGR
     LAALLRDRGV GPETRVAVAL PRSADLVVAL HAVQRAGGAY VPVDPDHPAD RVAHMLADAG
     PRLLITLTAL RERLPVPGDV PVLELDAPDA RAACAAAAPV GVHPGLRGEH AAYVLYTSGS
     TGRPKAVVVT HTALVNRLRW MAGHFPFGPE DRVLQKTPAG FDVSVWEFFL PMLTGSTLVV
     LPDGLHRDPA EVAEAVIRHG VTTVHFVPSM LAAFAAEPRA AHCTGLRRII ASGEALSAAL
     ARTVRAVLPG ASLHNLYGPT EAAIDVTAWE ATGEPGGSVP IGTPVHNTGA YVLDAGLRPV
     PDGVTGELYL SGPQLARGYL GRPGLTADRF VAHPFGAPGE RLYRTGDLVR RRADGALVYV
     GRTDGQIKLR GLRVELGEIE AVIAEEPRVA ASAVVLREDT PGRPVLTGYL VPATGTAPDP
     REITERIARR LPDHMVPTAL ITLDALPLTP SGKLDRTALP APDLAATASA VAPRGIREAV
     LTAVFAELLG IPAAGAEDSF FALGGDSILS IQLVARARRA GMALTPRDVF EHKTPAALAR
     AAATAGTTSV PRLDPAGRAP LTPIMRWALQ HGPIDGLHQY AHLVTPPEAT RATLTEALTR
     LMERHPMLRA ALVGEEGDRA LHIPGPADPA PEPVLLHVDA GAESAQRAAE LTAALAAEAV
     DQLDPAAGEL VRTVWCDRGP GRGGRLVLVV HHLAVDGVSW RILTADLAAA HDDVLAGNPA
     APPGGSTSFR QWALGLADAA TAPARRAEAP VWRAREERDV PALGARPLDP ALDTQETVAH
     LERTLDPDLT RALLTRVPAA VHGSVHDVLV AATALALDRR RRERGRRAGR DVIAVEGHGR
     EENAMPGAEL STTVGWFTSW YPVAPDLGAP GRSPSAGTAG DEALRALMAV KEHLRETPDR
     GIGHGLLHHL DDPAGPSRTP EVVLNYLGRF PGPAGRAEGA EPAAWSPAPE ALPALRPVRN
     TVPVLFPLEI IASTVDGPDG PRLATRWTYA TGILDAEDTE RLLDLWCEAL HTLADTPSDP
     VHTPSDFPLV RLDQGQVDAL QARSPGLRDV WPLTPLQEGL YALTHLAGDD IDVYTMQLVL
     RLAGRLDPAA LRRAAADLLD RNPGLRTAFV AAGGRPVQTV LDGVAPDWSE NDLRPEPAHA
     REEALRALAE DDRTRPFDLT APPLLRLRLV RTGEGEHALL VTNHHAILDG WSVPVLIQEL
     LSLYASLTGP AEPPLRRRSF RDFLAWRTAQ DERAAQDAWR SALDGVTEPT LIAPADPGRR
     PALPDRIQHR LDATLRERLQ TLARSADVTL NTVIQFAWGL LLARHTGRDD VVFGATVSGR
     PPEIDDVETM TGLFINTLPV RVDLRAGGTV RQALARLQAE QAKLSGHQHL GLADIQRSTG
     AGELFDTLLV FENYFVDGEG LRRAERSGEL TVTGSEHTDA THYPLTLAVV PGGHLTLEYR
     PDLFGPERAA ALMERFAHLL ADIGSRPDTR VHGLQALAPD ERRRILDDWN PAPRPHPEQT
     LPGLFAEAAA VDPGAPALVR GDTVLSFRDV TERAARLAHE LIARGVGPED LVALMLPRTE
     EMLISILAVH QAGAAYLPLD PDYPAERVVF MLADASPAVL LTTTALAGRA GHPATVLLDD
     PGTRAALATR SVRPPTDAER AHPLRPENPA YLIYTSGSTG TPKGVVVTHR SVVNLFHSHR
     RALYEPVVER TGRSRLHVGH AWSFSFDASW QPQLWMFHGH CVHVLTEDVQ RDPDRLHRYL
     RDHAIDFIEV APTVLAQLEE AGLTEGGSCP LPLLGVGGEA VPDGQWARLR ELPGTDVVNL
     YGPTEGTVDA MIAHVRDSER QLIGRAVDNA RVHLLDAGLR PVPPGVPGEM YLAGAGLARG
     YRGRAALTSE RFVADPFGAD GGRLYRTGDL GRWTVDGAVE FLGRVDDQVK IRGFRIEPGE
     IETVAAAHPE LSRVAVVARE DAGVRRLVAY GVPRPGGAPD PLALRAWLAE RLPGHLVPAA
     VVLLDALPVT ANAKLDRDRL PAPDFGAAAG GREPVGERER AVCAAMAQVL ALPRIGADDD
     FFALGGDSVV TVRLAGLLRS GGWEAAPRDV FRHRTAAGLA AGLRRQDAHS GG
//

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