(data stored in ACNUC7421 zone)

SWISSPROT: B1VQI7_STRGG

ID   B1VQI7_STRGG            Unreviewed;       363 AA.
AC   B1VQI7;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   07-JUN-2017, entry version 62.
DE   RecName: Full=Putative glutamate--cysteine ligase 2 {ECO:0000256|HAMAP-Rule:MF_01609};
DE            EC=6.3.2.2 {ECO:0000256|HAMAP-Rule:MF_01609};
DE   AltName: Full=Gamma-glutamylcysteine synthetase 2 {ECO:0000256|HAMAP-Rule:MF_01609};
DE            Short=GCS 2 {ECO:0000256|HAMAP-Rule:MF_01609};
DE            Short=Gamma-GCS 2 {ECO:0000256|HAMAP-Rule:MF_01609};
GN   OrderedLocusNames=SGR_459 {ECO:0000313|EMBL:BAG17288.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17288.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17288.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: ATP-dependent carboxylate-amine ligase which exhibits
CC       weak glutamate--cysteine ligase activity. {ECO:0000256|HAMAP-
CC       Rule:MF_01609}.
CC   -!- CATALYTIC ACTIVITY: ATP + L-glutamate + L-cysteine = ADP +
CC       phosphate + gamma-L-glutamyl-L-cysteine. {ECO:0000256|HAMAP-
CC       Rule:MF_01609, ECO:0000256|SAAS:SAAS00378060}.
CC   -!- SIMILARITY: Belongs to the glutamate--cysteine ligase type 2
CC       family. YbdK subfamily. {ECO:0000256|HAMAP-Rule:MF_01609,
CC       ECO:0000256|SAAS:SAAS00809443}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AP009493; BAG17288.1; -; Genomic_DNA.
DR   RefSeq; WP_012377811.1; NC_010572.1.
DR   ProteinModelPortal; B1VQI7; -.
DR   STRING; 455632.SGR_459; -.
DR   EnsemblBacteria; BAG17288; BAG17288; SGR_459.
DR   GeneID; 6211580; -.
DR   KEGG; sgr:SGR_459; -.
DR   PATRIC; fig|455632.4.peg.436; -.
DR   eggNOG; ENOG4106PVI; Bacteria.
DR   eggNOG; COG2170; LUCA.
DR   HOGENOM; HOG000220943; -.
DR   KO; K06048; -.
DR   OMA; EWERWPS; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004357; F:glutamate-cysteine ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042398; P:cellular modified amino acid biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_01609; Glu_cys_ligase_2; 1.
DR   InterPro; IPR006336; GCS2.
DR   InterPro; IPR011793; YbdK.
DR   Pfam; PF04107; GCS2; 1.
DR   TIGRFAMs; TIGR02050; gshA_cyan_rel; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1VQI7.
DR   SWISS-2DPAGE; B1VQI7.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01609,
KW   ECO:0000256|SAAS:SAAS00078237};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Ligase {ECO:0000256|HAMAP-Rule:MF_01609,
KW   ECO:0000256|SAAS:SAAS00078241};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01609,
KW   ECO:0000256|SAAS:SAAS00078244};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685}.
SQ   SEQUENCE   363 AA;  39485 MW;  F993BB4FAFF25217 CRC64;
     MVRTVGVEEE LLLVDEVSGE ARALSSAVLA IAEKEADGES AFESELHRQQ VEFSTHPCAS
     MEELAASVRR WRTEAVRHAT EAGASVAALA TSPLPVSPTI GTGERYRWLA ERFGLTAQEQ
     LTCGCHVHVS VASEEEGVAV LDRIRPWLPV LLALSANSPF WQGQDSRYSS YRGQVWGRWP
     SAGPADVHGS AEAYHAQVRS LVATGVLRDE GMVYFDARLS HRYPTVEVRI ADVCLDPADT
     VLLATLVRGL VETAARAWRA GEPPGDVSTS LLRVASWQAG RWGLEDRLVH PRTLCPEPAS
     EVLRALLDQV REALEDSGDL ADAERALAEV LRRGNGARIQ REILARTGSL RDTVAECVRI
     SAG
//

If you have problems or comments...

PBIL Back to PBIL home page