(data stored in ACNUC7421 zone)

SWISSPROT: B1VRG2_STRGG

ID   B1VRG2_STRGG            Unreviewed;       147 AA.
AC   B1VRG2;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   30-AUG-2017, entry version 57.
DE   RecName: Full=Probable subtilase-type protease inhibitor {ECO:0000256|HAMAP-Rule:MF_00778};
DE   Flags: Precursor;
GN   Name=sgiA {ECO:0000313|EMBL:BAG17380.1};
GN   Synonyms=sti {ECO:0000256|HAMAP-Rule:MF_00778};
GN   OrderedLocusNames=SGR_551 {ECO:0000313|EMBL:BAG17380.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17380.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17380.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: Strong inhibitor of bacterial serine proteases such as
CC       subtilisin. {ECO:0000256|HAMAP-Rule:MF_00778}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00778}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|HAMAP-Rule:MF_00778}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I16 (SSI) family.
CC       {ECO:0000256|HAMAP-Rule:MF_00778, ECO:0000256|RuleBase:RU003471}.
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DR   EMBL; AP009493; BAG17380.1; -; Genomic_DNA.
DR   RefSeq; WP_003964415.1; NC_010572.1.
DR   ProteinModelPortal; B1VRG2; -.
DR   SMR; B1VRG2; -.
DR   STRING; 455632.SGR_551; -.
DR   EnsemblBacteria; BAG17380; BAG17380; SGR_551.
DR   GeneID; 6210071; -.
DR   KEGG; sgr:SGR_551; -.
DR   PATRIC; fig|455632.4.peg.533; -.
DR   eggNOG; ENOG4106C4P; Bacteria.
DR   eggNOG; ENOG410XZAM; LUCA.
DR   OMA; VTLTCAP; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.30.350.10; -; 1.
DR   HAMAP; MF_00778; SSI; 1.
DR   InterPro; IPR000691; Prot_inh_I16_SSI.
DR   InterPro; IPR023549; Subtilisin_inhibitor.
DR   Pfam; PF00720; SSI; 1.
DR   PRINTS; PR00294; SSBTLNINHBTR.
DR   ProDom; PD004028; Prot_inh_SSI; 1.
DR   SUPFAM; SSF55399; SSF55399; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1VRG2.
DR   SWISS-2DPAGE; B1VRG2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Disulfide bond {ECO:0000256|HAMAP-Rule:MF_00778};
KW   Hydrolase {ECO:0000313|EMBL:BAG17380.1};
KW   Protease {ECO:0000313|EMBL:BAG17380.1};
KW   Protease inhibitor {ECO:0000256|HAMAP-Rule:MF_00778,
KW   ECO:0000256|RuleBase:RU003471};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685};
KW   Secreted {ECO:0000256|HAMAP-Rule:MF_00778};
KW   Serine protease inhibitor {ECO:0000256|HAMAP-Rule:MF_00778,
KW   ECO:0000256|RuleBase:RU003471};
KW   Signal {ECO:0000256|HAMAP-Rule:MF_00778}.
FT   SIGNAL        1     29       {ECO:0000256|HAMAP-Rule:MF_00778}.
FT   CHAIN        30    147       Probable subtilase-type protease
FT                                inhibitor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00778}.
FT                                /FTId=PRO_5009007502.
FT   DOMAIN       39    131       SSI. {ECO:0000259|Pfam:PF00720}.
FT   SITE        105    106       Reactive bond. {ECO:0000256|HAMAP-Rule:
FT                                MF_00778}.
FT   DISULFID     66     81       {ECO:0000256|HAMAP-Rule:MF_00778}.
FT   DISULFID    103    133       {ECO:0000256|HAMAP-Rule:MF_00778}.
SQ   SEQUENCE   147 AA;  15020 MW;  56618F0DCB96F6EA CRC64;
     MRRNPHAAFA TVTATALLLG GFATATAQAA PAGAPSLYAP SALVLTVARG EDPLTATVER
     AVTLTCAPTA EGTHPTPAAA CKELAAVQGK FSELTAGPSN RTCTRQWDPV VVSAHGAWQG
     RQVRFSTTYG NACEMAGSTN GNAVFAF
//

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