(data stored in ACNUC7421 zone)

SWISSPROT: ACDH_STRGG

ID   ACDH_STRGG              Reviewed;         308 AA.
AC   B1VRH6;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   07-JUN-2017, entry version 57.
DE   RecName: Full=Acetaldehyde dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01657};
DE            EC=1.2.1.10 {ECO:0000255|HAMAP-Rule:MF_01657};
DE   AltName: Full=Acetaldehyde dehydrogenase [acetylating] {ECO:0000255|HAMAP-Rule:MF_01657};
GN   OrderedLocusNames=SGR_565;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: Catalyzes the conversion of acetaldehyde to acetyl-CoA,
CC       using NAD(+) and coenzyme A. Is the final enzyme in the meta-
CC       cleavage pathway for the degradation of aromatic compounds.
CC       {ECO:0000255|HAMAP-Rule:MF_01657}.
CC   -!- CATALYTIC ACTIVITY: Acetaldehyde + CoA + NAD(+) = acetyl-CoA +
CC       NADH. {ECO:0000255|HAMAP-Rule:MF_01657}.
CC   -!- SIMILARITY: Belongs to the acetaldehyde dehydrogenase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01657}.
DR   EMBL; AP009493; BAG17394.1; -; Genomic_DNA.
DR   RefSeq; WP_012377889.1; NC_010572.1.
DR   ProteinModelPortal; B1VRH6; -.
DR   SMR; B1VRH6; -.
DR   STRING; 455632.SGR_565; -.
DR   EnsemblBacteria; BAG17394; BAG17394; SGR_565.
DR   GeneID; 6211317; -.
DR   KEGG; sgr:SGR_565; -.
DR   PATRIC; fig|455632.4.peg.547; -.
DR   eggNOG; ENOG4105DIV; Bacteria.
DR   eggNOG; COG4569; LUCA.
DR   HOGENOM; HOG000052149; -.
DR   KO; K04073; -.
DR   OMA; VEYVEIV; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_01657; Ac_ald_DH_ac; 1.
DR   InterPro; IPR003361; Acetaldehyde_dehydrogenase.
DR   InterPro; IPR015426; Acetylaldehyde_DH_C.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR   Pfam; PF09290; AcetDehyd-dimer; 1.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   PIRSF; PIRSF015689; Actaldh_dh_actl; 1.
DR   SMART; SM00859; Semialdhyde_dh; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR03215; ac_ald_DH_ac; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1VRH6.
DR   SWISS-2DPAGE; B1VRH6.
KW   Aromatic hydrocarbons catabolism; Complete proteome; NAD;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN         1    308       Acetaldehyde dehydrogenase.
FT                                /FTId=PRO_0000387747.
FT   NP_BIND      25     28       NAD. {ECO:0000255|HAMAP-Rule:MF_01657}.
FT   ACT_SITE    139    139       Acyl-thioester intermediate.
FT                                {ECO:0000255|HAMAP-Rule:MF_01657}.
FT   BINDING     279    279       NAD. {ECO:0000255|HAMAP-Rule:MF_01657}.
SQ   SEQUENCE   308 AA;  31579 MW;  F01F6611BB0D8159 CRC64;
     MSLTAGLTDA RPDTVETATV AVIGTGAIGR DLVSKIDRSP GLDCRLVAGR NPESAGLRYA
     ESLGCATTAA GIDAVLAASP FDVVFDATSA ASHRDHWPLL EPLGTLVIDL TPSKVGQMVA
     PTVTGVAAED ARNVNLISCG GQASVPVVHA LAARFPVTYL EVVSTVASDV AGRATRLNLD
     EYVTATGHAV TTFSGVSDVK IILNISPAVP PATFRTVIHA RVPDADAAAV RAVVDRAAEQ
     VRSFAPGYEV VACTAADDLV TIVLKVTACS DVLPPYAGNL DIINAAAVLV AEQYAARPGR
     VSRTGVSS
//

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