(data stored in ACNUC7421 zone)

SWISSPROT: B1VRM0_STRGG

ID   B1VRM0_STRGG            Unreviewed;      1946 AA.
AC   B1VRM0;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   08-MAY-2019, entry version 69.
DE   SubName: Full=Putative iterative type-I PKS for enediyne biosynthesis {ECO:0000313|EMBL:BAG17438.1};
GN   Name=pksE {ECO:0000313|EMBL:BAG17438.1};
GN   OrderedLocusNames=SGR_609 {ECO:0000313|EMBL:BAG17438.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17438.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17438.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
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DR   EMBL; AP009493; BAG17438.1; -; Genomic_DNA.
DR   RefSeq; WP_012377924.1; NC_010572.1.
DR   STRING; 455632.SGR_609; -.
DR   EnsemblBacteria; BAG17438; BAG17438; SGR_609.
DR   GeneID; 6215147; -.
DR   KEGG; sgr:SGR_609; -.
DR   PATRIC; fig|455632.4.peg.593; -.
DR   eggNOG; ENOG4107EEY; Bacteria.
DR   eggNOG; COG3321; LUCA.
DR   HOGENOM; HOG000268502; -.
DR   KO; K15314; -.
DR   OMA; AFWCARR; -.
DR   OrthoDB; 1123553at2; -.
DR   BioCyc; SGRI455632:G1G2X-603-MONOMER; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   Gene3D; 3.10.129.110; -; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR032821; KAsynt_C_assoc.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR020807; PKS_dehydratase.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52151; SSF52151; 1.
DR   SUPFAM; SSF53901; SSF53901; 1.
DR   SUPFAM; SSF55048; SSF55048; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   4: Predicted;
DR   PRODOM; B1VRM0.
DR   SWISS-2DPAGE; B1VRM0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Phosphopantetheine {ECO:0000256|PROSITE-ProRule:PRU00258}.
FT   DOMAIN      934   1010       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   MOD_RES     969    969       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   1946 AA;  203711 MW;  EA38297B1522634B CRC64;
     MSRIAIVGVS CSYPDATTPR ELWENAVAGR RAFRRLPDVR MRLDDYYDPD PAVPDKFYAR
     NAAVLEGWEF DRVAHRIAGG TYRSTDLTHW LALDTATRAL ADAGFPAGEG LPRERTGVVV
     GNTLTGEFAR ANVMRLRWPY VRRVLADALK GQDWGDERLG AFLEGVEDAY KQPFPAIDED
     TLAGGLSNTI AGRICNHFDL NGGGYTVDGA CSSSLLSVTT ASASLLNGDL DVAVAGGVDM
     SIDPFEIIGF AKTGALARTE MRLYDRGSNG FWPGEGCGMV VLMREEDALA AGHRVYASIA
     GWGISSDGQG GITRPEVSGY QLALARAYER AGFGIDTVPL FEGHGTGTAV GDATELRAIM
     GARAQADPHA PSAAISSVKG MIGHTKAAAG IAGLIKATMA LDAAMLPPAI GCVDPHELLT
     EESANLRVLR RAEAWPSGAP LRAGITAMGF GGINTHVVLD RALPTGRRTL SRRSTTLANS
     LQDAELLLLD AASPQALRER LSQVADFAVT VSYAQLADLA ATLQRELREL PHRAAVVVTS
     PEDAEVRLRR LAQVPNTDGS ITLSPDGRAF IGRAKDAARI GFLFPGQGSG TSTGGGALAR
     RFTEAADVYR RAGLPTTGDM VATDVAQPRI VTGSTAGLRV LDALGIEADI AVGHSLGELS
     ALHWAGALDS TTLLEAARVR GAAMAEHSAS GTMASLAATP EEAGELIADL PVVVSGYNGP
     RQTVVAGTVE AIATVSERAE RAGVSCTGLA VSHAFHSPLV APAADAFGDW LAGERLAEVD
     RRVVSTVTGE DLESDTDLSK LLRQQITDPV LFTQAVRAAA PDVDLFVEVG PGRVLTGMAA
     ATADVPAVAL NTDDESLRGL LQVVGAAYVL GAPLIHERLF NDRLTRPLEV GAEFSFLASP
     CEQAPDVALP AMRAPRAEGS GDGATERAGG SAGESALDVL RALVAERAEL PPELVDDSSN
     LLDDLHMSSI TVGQIVNQAA VQLGLTAAHV PTNFATATMA ELAEALTTLA GTDDGDAPAP
     VVAGAAAWAR PFAVDLDEVL LPAPVSGGDN GSWELFTAQD HPFAQDVRSA LEKAAVGSGV
     LVCLPPDCSR EQIEHALEGA KAALAGDRER RFVLVQHGRG AAGLAKTLHL EASHLRTTVV
     HTPVCDGAAE RVAAEVAATA RFNEVHLAAD GTRRVPVLRA LPIRAERTEQ VLGDSDVLLV
     TGGGKGITAE CALAVARQTG VKLAVLGRSD PARDEDLAAN LRRMADSGAT VRYARADVTD
     PVRVAAAVAE LTDALGPVTA VLHGAGRNEP ASLSGLGMDD FHATFAPKVD GLDVVLDAVG
     EGNLKLLVTF GSIIGRSGLR GEAHYATANE WLADRTEQVA RDHPGCRALC MEWSVWSGIG
     MGEKLSVVES LSREGIVPVS PDQGVEILLR LISDPDAPVV TVISGRTEGI GTVRRDLPPM
     PLLRFTGTPL VRYHGVELVT EAELNAGTDL YLADHLLDDN LLMPAVIGME AMVQVASALT
     GRADVPVIEG ARFLRPIVVP PAGTTRIRIA ATVTDTDTVD VAVHAEDTGF VAEHFRARLV
     YSGAAVPDGP PAQVGPDVPP APLDPAADLY GGFLFQGERF QRLRRFRRAA ARHVDADVAI
     AAPSGWFAGF LPDTLLLADP GMRDALMHGN QVCVPDATLL PSGIERLYPM PAGGDLPQEV
     RYCATERHRD GDTYVYDIAV RTADGTAVER WEGLTLHAVR KTDGSGPWVA PLLGPYLERA
     VEEVLGTHLD IAVEPDLPGA GESADERRAA TARAVQRALG ESAEVRYRPD GRPELVGGRE
     ISAAHGLGVT LGVAAAGTVA CDIEAVCVRD ADTWAGLLGE HAGLAAQVVK QTGEAPDTAA
     TRVWGAVECL RKAGLMAGAP LTLTPPNRDN WVVLASGGLR IATFVTALRD ALEPAVVAFL
     APIPDASAPA PASSAAGRRP PTGRQT
//

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