(data stored in ACNUC7421 zone)

SWISSPROT: B1VRP9_STRGG

ID   B1VRP9_STRGG            Unreviewed;       324 AA.
AC   B1VRP9;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   07-JUN-2017, entry version 60.
DE   RecName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000256|RuleBase:RU004473};
DE            EC=4.2.1.46 {ECO:0000256|RuleBase:RU004473};
GN   OrderedLocusNames=SGR_638 {ECO:0000313|EMBL:BAG17467.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17467.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17467.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CATALYTIC ACTIVITY: dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-
CC       alpha-D-glucose + H(2)O. {ECO:0000256|RuleBase:RU004473}.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|RuleBase:RU004473};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. dTDP-glucose dehydratase subfamily.
CC       {ECO:0000256|RuleBase:RU004473}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AP009493; BAG17467.1; -; Genomic_DNA.
DR   RefSeq; WP_012377945.1; NC_010572.1.
DR   ProteinModelPortal; B1VRP9; -.
DR   STRING; 455632.SGR_638; -.
DR   EnsemblBacteria; BAG17467; BAG17467; SGR_638.
DR   GeneID; 6209581; -.
DR   KEGG; sgr:SGR_638; -.
DR   PATRIC; fig|455632.4.peg.623; -.
DR   eggNOG; ENOG4105C1B; Bacteria.
DR   eggNOG; COG1088; LUCA.
DR   HOGENOM; HOG000168006; -.
DR   KO; K01710; -.
DR   OMA; LDNKQWW; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR   InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01181; dTDP_gluc_dehyt; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1VRP9.
DR   SWISS-2DPAGE; B1VRP9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Lyase {ECO:0000256|RuleBase:RU004473};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685}.
FT   DOMAIN        4    305       NAD(P)-bd_dom. {ECO:0000259|Pfam:
FT                                PF16363}.
SQ   SEQUENCE   324 AA;  36068 MW;  73CDE1772EB32B38 CRC64;
     MRILVTGGAG FIGSHYARSL LAGRYGAAPD TRITVLDKLT YAGDRGNLPA HHDRLEFVRG
     DVCDGALLRE LLPGHDAIVH FAAESHVDRS VAGGREFVRT NALGTQVLLE AASLSRVERV
     LHISTDEVYG SIEQGSWTEE RPLLPNSPYA ASKASADLIA RSYWRTHGLD VSITRCSNNY
     GPYQHPEKLV PRFVTNLLRG RKVPVYGDGR NRREWIHVDD HCRAIHLVLA KGGAGEIYNV
     GSGDELENLR LAEHLLALCG ADASMIEYVE DRKGHDLRYA LDDTKIREQL GYEPQVPLDR
     GIAETVAWYE ANPRWWQAAG RREE
//

If you have problems or comments...

PBIL Back to PBIL home page