(data stored in ACNUC7421 zone)

SWISSPROT: B1VRU4_STRGG

ID   B1VRU4_STRGG            Unreviewed;       427 AA.
AC   B1VRU4;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   07-JUN-2017, entry version 61.
DE   RecName: Full=Glutaminase {ECO:0000256|HAMAP-Rule:MF_00313, ECO:0000256|SAAS:SAAS00041476};
DE            EC=3.5.1.2 {ECO:0000256|HAMAP-Rule:MF_00313, ECO:0000256|SAAS:SAAS00041476};
GN   Name=glsA {ECO:0000256|HAMAP-Rule:MF_00313};
GN   OrderedLocusNames=SGR_683 {ECO:0000313|EMBL:BAG17512.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17512.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17512.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CATALYTIC ACTIVITY: L-glutamine + H(2)O = L-glutamate + NH(3).
CC       {ECO:0000256|HAMAP-Rule:MF_00313, ECO:0000256|SAAS:SAAS00062832}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00313,
CC       ECO:0000256|SAAS:SAAS00551681}.
CC   -!- SIMILARITY: Belongs to the glutaminase family. {ECO:0000256|HAMAP-
CC       Rule:MF_00313, ECO:0000256|SAAS:SAAS00551679}.
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DR   EMBL; AP009493; BAG17512.1; -; Genomic_DNA.
DR   RefSeq; WP_012377985.1; NC_010572.1.
DR   ProteinModelPortal; B1VRU4; -.
DR   STRING; 455632.SGR_683; -.
DR   EnsemblBacteria; BAG17512; BAG17512; SGR_683.
DR   GeneID; 6211410; -.
DR   KEGG; sgr:SGR_683; -.
DR   PATRIC; fig|455632.4.peg.666; -.
DR   eggNOG; ENOG4105CSV; Bacteria.
DR   eggNOG; COG2066; LUCA.
DR   HOGENOM; HOG000216890; -.
DR   KO; K01425; -.
DR   OMA; MYTCGMY; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR   Gene3D; 3.30.750.24; -; 1.
DR   HAMAP; MF_00313; Glutaminase; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR015868; Glutaminase.
DR   InterPro; IPR002645; STAS_dom.
DR   PANTHER; PTHR12544; PTHR12544; 1.
DR   Pfam; PF04960; Glutaminase; 1.
DR   SUPFAM; SSF52091; SSF52091; 1.
DR   SUPFAM; SSF56601; SSF56601; 1.
DR   TIGRFAMs; TIGR03814; Gln_ase; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1VRU4.
DR   SWISS-2DPAGE; B1VRU4.
KW   Acetylation {ECO:0000256|HAMAP-Rule:MF_00313};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00313,
KW   ECO:0000256|SAAS:SAAS00041473};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685}.
FT   DOMAIN      332    396       STAS. {ECO:0000259|PROSITE:PS50801}.
FT   BINDING      64     64       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00313}.
FT   BINDING     114    114       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00313}.
FT   BINDING     160    160       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00313}.
FT   BINDING     167    167       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00313}.
FT   BINDING     191    191       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00313}.
FT   BINDING     243    243       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00313}.
FT   BINDING     261    261       Substrate; via amide nitrogen.
FT                                {ECO:0000256|HAMAP-Rule:MF_00313}.
SQ   SEQUENCE   427 AA;  44947 MW;  B8AB40F35ADF4397 CRC64;
     MRPIIPDYLA EVLEQVEPDA SGAPAAYIPE LAEADPERLG AAFATVDGRV HGAGDIDVPF
     TIQSISKPFA YALALADRGF GTVLAKVGVE PSGEAFNEIS LESGTGRPLN PMINAGAITV
     HSLVAEAGSG PAERVRRVLD GLSAFAGRRL ETDEKVCASE LEHAHRNLAI AHMLRGHDIL
     TEDVRAVVDG YTRQCSVLVT TRDLAVMAAT LANRGVNPLS GEQVVPEGVV RQVLSVMFSC
     GMYDAAGDWA TQVGIPAKSG VAGGLIGALP GRIGIATFSP RLDSHGNSVR GVSLFERFSS
     DMGLHVMEVP SAGRAAVRSS HVLGGGPDAL RVLELQGGIG FAGAERVVRE VLDTDPREAR
     VAIDLTRVHA IDDVARRMVL EIARRLTLDG REVFLVDPEA VIPDPDPGDG GRVTVIREVR
     QAVPPGA
//

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