(data stored in ACNUC7421 zone)

SWISSPROT: B1VRW5_STRGG

ID   B1VRW5_STRGG            Unreviewed;       805 AA.
AC   B1VRW5;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   07-JUN-2017, entry version 73.
DE   RecName: Full=UvrABC system protein A {ECO:0000256|SAAS:SAAS00385002};
GN   OrderedLocusNames=SGR_704 {ECO:0000313|EMBL:BAG17533.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17533.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17533.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrA is an ATPase and a DNA-binding
CC       protein. A damage recognition complex composed of 2 UvrA and 2
CC       UvrB subunits scans DNA for abnormalities. When the presence of a
CC       lesion has been verified by UvrB, the UvrA molecules dissociate.
CC       {ECO:0000256|SAAS:SAAS00571360}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC       lesions. {ECO:0000256|SAAS:SAAS00571359}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00385027}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA
CC       family. {ECO:0000256|SAAS:SAAS00571366}.
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DR   EMBL; AP009493; BAG17533.1; -; Genomic_DNA.
DR   RefSeq; WP_012378002.1; NC_010572.1.
DR   ProteinModelPortal; B1VRW5; -.
DR   STRING; 455632.SGR_704; -.
DR   EnsemblBacteria; BAG17533; BAG17533; SGR_704.
DR   GeneID; 6216097; -.
DR   KEGG; sgr:SGR_704; -.
DR   PATRIC; fig|455632.4.peg.686; -.
DR   eggNOG; ENOG4105C5U; Bacteria.
DR   eggNOG; COG0178; LUCA.
DR   HOGENOM; HOG000050449; -.
DR   KO; K03701; -.
DR   OMA; GAWQGKN; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004602; UvrA.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   TIGRFAMs; TIGR00630; uvra; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1VRW5.
DR   SWISS-2DPAGE; B1VRW5.
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00434,
KW   ECO:0000256|SAAS:SAAS00089089};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00089055};
KW   DNA damage {ECO:0000256|SAAS:SAAS00088992};
KW   DNA excision {ECO:0000256|SAAS:SAAS00088971};
KW   DNA repair {ECO:0000256|SAAS:SAAS00461409};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00088984};
KW   Excision nuclease {ECO:0000256|SAAS:SAAS00089033};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00088968};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00434,
KW   ECO:0000256|SAAS:SAAS00089112};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685};
KW   Repeat {ECO:0000256|SAAS:SAAS00088976};
KW   Zinc {ECO:0000256|SAAS:SAAS00089006};
KW   Zinc-finger {ECO:0000256|SAAS:SAAS00088978}.
FT   DOMAIN      464    800       ABC transporter. {ECO:0000259|PROSITE:
FT                                PS50893}.
FT   NP_BIND     501    508       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00434}.
SQ   SEQUENCE   805 AA;  85782 MW;  12AE54FB46A19564 CRC64;
     MHSPHDPYVR VRGAREHNLK NVRVDIPRDT LTVFTGVSGS GKSSLAFGTI YAEAQRRYFE
     SVAPYARRLI HQVGAPAVGE ITGLPPAVSL EQRRSAPGAR SSVGTVTTLS NSLRLLFSRA
     GDYPPGAERL DSDSFSPNTA VGACPECHGL GRIHRTDEAL LVPDPSLSIR EGAIAAWPGA
     WQGKNLRDVL DALGHDVDRP WRELDPKDRE WILFTDEQPV VTVHPVRDAG RIQRPYQGTY
     MSARRYVLHT FADTRSRALR AKAERFLTSA PCPVCGGSRL RPEAMAVTFA GRTIAELAGL
     PLSALAEVLS GAGAGGEETA RVLTADLLAR IGTVTELGLG YLSLDRTAPT LSSGELQRLR
     LATQLRSGLF GVVYVLDEPS AGLHPADTEA LLGVLGRLKE AGNSVFVVEH QMDVVRRADW
     LVDVGPLAGE HGGRVLHSGP PEGLARVPES ATRRFLFEEG PAPVREPRVP TGWIRLSGVE
     RHNVRGADAA FPLGVFTAVT GVSGSGKSTL VGQVLAGVLA DRQAGEEATG AGERFCASVT
     GLEAVDRLVQ VDQKPIGRTP RSNLATYTGL FDAVRKLFAG TDAARERGYT AGRFSFNVSG
     GRCETCQGEG FVSVELLFLP STYAPCPDCH GARYNPRTLD VTLNGLTIAQ VLELTVESAA
     SFFAGTPAAE RALTTLLDVG LGYLRLGQPA TELSGGEAQR IKLAAELQRT RRGHTLYLLD
     EPTTGLHPAD VEVLMRQLHS LVDAGGTVVV VEHDMAVVAG ADHVIDLGPE GGDRGGRIVA
     AGTPAEVARE AGSRTAPYLA KALRH
//

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