(data stored in ACNUC7421 zone)

SWISSPROT: B1VRY5_STRGG

ID   B1VRY5_STRGG            Unreviewed;       286 AA.
AC   B1VRY5;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   07-JUN-2017, entry version 64.
DE   SubName: Full=Putative formamidopyrimidine-DNA glycosylase {ECO:0000313|EMBL:BAG17553.1};
GN   OrderedLocusNames=SGR_724 {ECO:0000313|EMBL:BAG17553.1};
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632 {ECO:0000313|EMBL:BAG17553.1, ECO:0000313|Proteomes:UP000001685};
RN   [1] {ECO:0000313|EMBL:BAG17553.1, ECO:0000313|Proteomes:UP000001685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350 {ECO:0000313|Proteomes:UP000001685};
RX   PubMed=18375553; DOI=10.1128/JB.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism
RT   Streptomyces griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or
CC       apyrimidinic site in DNA is broken by a beta-elimination reaction,
CC       leaving a 3'-terminal unsaturated sugar and a product with a
CC       terminal 5'-phosphate. {ECO:0000256|SAAS:SAAS00643435}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|SAAS:SAAS00643423};
CC   -!- SIMILARITY: Belongs to the FPG family.
CC       {ECO:0000256|SAAS:SAAS00643420}.
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DR   EMBL; AP009493; BAG17553.1; -; Genomic_DNA.
DR   RefSeq; WP_012378014.1; NC_010572.1.
DR   ProteinModelPortal; B1VRY5; -.
DR   STRING; 455632.SGR_724; -.
DR   EnsemblBacteria; BAG17553; BAG17553; SGR_724.
DR   GeneID; 6209483; -.
DR   KEGG; sgr:SGR_724; -.
DR   PATRIC; fig|455632.4.peg.711; -.
DR   eggNOG; ENOG4105EQC; Bacteria.
DR   eggNOG; COG0266; LUCA.
DR   HOGENOM; HOG000020886; -.
DR   KO; K10563; -.
DR   OMA; LQYCPTC; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IEA:InterPro.
DR   GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   InterPro; IPR015886; DNA_glyclase/AP_lyase_DNA-bd.
DR   InterPro; IPR012319; FPG_cat.
DR   InterPro; IPR010979; Ribosomal_S13-like_H2TH.
DR   InterPro; IPR000214; Znf_DNA_glyclase/AP_lyase.
DR   InterPro; IPR010663; Znf_FPG/IleRS.
DR   Pfam; PF01149; Fapy_DNA_glyco; 1.
DR   Pfam; PF06831; H2TH; 1.
DR   Pfam; PF06827; zf-FPG_IleRS; 1.
DR   SMART; SM00898; Fapy_DNA_glyco; 1.
DR   SMART; SM01232; H2TH; 1.
DR   SUPFAM; SSF46946; SSF46946; 1.
DR   SUPFAM; SSF81624; SSF81624; 1.
DR   PROSITE; PS51068; FPG_CAT; 1.
DR   PROSITE; PS51066; ZF_FPG_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B1VRY5.
DR   SWISS-2DPAGE; B1VRY5.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001685};
KW   DNA damage {ECO:0000256|SAAS:SAAS00643418};
KW   DNA repair {ECO:0000256|SAAS:SAAS00643382};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00643405};
KW   Glycosidase {ECO:0000256|SAAS:SAAS00643419};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00643430};
KW   Lyase {ECO:0000256|SAAS:SAAS00643421};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00640292};
KW   Multifunctional enzyme {ECO:0000256|SAAS:SAAS00643397};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001685};
KW   Zinc {ECO:0000256|SAAS:SAAS00640325};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00391,
KW   ECO:0000256|SAAS:SAAS00640308}.
FT   DOMAIN        2    119       FPG_CAT. {ECO:0000259|PROSITE:PS51068}.
FT   DOMAIN      237    271       FPG-type. {ECO:0000259|PROSITE:PS51066}.
SQ   SEQUENCE   286 AA;  30940 MW;  679F18E896B3FCCC CRC64;
     MPELPEVEAL RVFLDDHLVG KEIARVLPLA ISVLKTYDPP LSALEGTTVT SVARHGKFLD
     IEAGGLHLCT HLARAGWLRW KDSFPAAPPR PGKGPLALRL ITVDGDGFDL TEMGTRKRLS
     VHLVHDPADV PGIARLGPDP LADAFDRDAF AALLAGERRQ IKGALRDQSL IAGIGNAYSD
     EILHVAKMSP FKRTADLDED DVTRLYTALR STLQDAVTRS SGVEAGKLKA EKKTGMRVHG
     RTGEACPVCG DTILEVSFSD SSLQYCPTCQ TGGKPLADRR LSKFLK
//

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