(data stored in ACNUC30567 zone)

SWISSPROT: B4DDY3_HUMAN

ID   B4DDY3_HUMAN            Unreviewed;       307 AA.
AC   B4DDY3;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   11-DEC-2019, entry version 83.
DE   SubName: Full=cDNA FLJ60418, highly similar to ADAM 28 {ECO:0000313|EMBL:BAG56894.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG56894.1};
RN   [1] {ECO:0000313|EMBL:BAG56894.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Bladder {ECO:0000313|EMBL:BAG56894.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AK293382; BAG56894.1; -; mRNA.
DR   PeptideAtlas; B4DDY3; -.
DR   PRIDE; B4DDY3; -.
DR   ProteomicsDB; 3905; -.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   HOGENOM; HOG000230883; -.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR018358; Disintegrin_CS.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   PRINTS; PR00289; DISINTEGRIN.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS00427; DISINTEGRIN_1; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; B4DDY3.
DR   SWISS-2DPAGE; B4DDY3.
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00877335}; Integrin {ECO:0000313|EMBL:BAG56894.1}.
FT   DOMAIN          1..166
FT                   /note="Peptidase M12B"
FT                   /evidence="ECO:0000259|PROSITE:PS50215"
FT   DOMAIN          174..260
FT                   /note="Disintegrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50214"
FT   DISULFID        232..252
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00068"
SQ   SEQUENCE   307 AA;  34121 MW;  B532B007F8B24359 CRC64;
     MANYVNMLYK KLNTHVALVG MEIWTDKDKI KITPNASFTL ENFSKWRGSV LSRRKRHDIA
     QLITATELAG TTVGLAFMST MCSPYSVGVV QDHSDNLLRV AGTMAHEMGH NFGMFHDDYS
     CKCPSTICVM DKALSFYIPT DFSSCSRLSY DKFFEDKLSN CLFNAPLPTD IISTPICGNQ
     LVEMGEDCDC GTSEECTNIC CDAKTCKIKA TFQCALGECC EKCQFKKAGM VCRPAKDECD
     LPEMCNGKSG NCPDDRFQVN GFPCHHGKGH CLMGTCPTLQ EQCTELWGPG RRTNPFPCAC
     AKENHFR
//

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