(data stored in ACNUC8465 zone)

SWISSPROT: B4DH44_HUMAN

ID   B4DH44_HUMAN            Unreviewed;       376 AA.
AC   B4DH44;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   11-DEC-2019, entry version 60.
DE   SubName: Full=cDNA FLJ52538, highly similar to Dual specificity mitogen-activated proteinkinase kinase 4 {ECO:0000313|EMBL:BAG58005.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG58005.1};
RN   [1] {ECO:0000313|EMBL:BAG58005.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAG58005.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|RuleBase:RU000304}.
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DR   EMBL; AK294923; BAG58005.1; -; mRNA.
DR   EPD; B4DH44; -.
DR   MaxQB; B4DH44; -.
DR   PeptideAtlas; B4DH44; -.
DR   PRIDE; B4DH44; -.
DR   ProteomicsDB; 4193; -.
DR   eggNOG; KOG0984; Eukaryota.
DR   eggNOG; ENOG410XT3F; LUCA.
DR   SignaLink; B4DH44; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; B4DH44.
DR   SWISS-2DPAGE; B4DH44.
KW   ATP-binding {ECO:0000256|RuleBase:RU000304};
KW   Kinase {ECO:0000313|EMBL:BAG58005.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
KW   Transferase {ECO:0000313|EMBL:BAG58005.1}.
FT   DOMAIN          79..344
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   376 AA;  42545 MW;  716A6044460CB19C CRC64;
     MAAPSPSGTP VSSMQGKRKA LKLNFANPPF KSTARFTLNP NPTGVQNPHI ERLRTHSIES
     SGKLKISPEQ HWDFTAEDLK DLGEIGRGAY GSVNKMVHKP SGQIMAVKRI RSTVDEKEQK
     QLLMDLDVVM RSSDCPYIVQ FYGALFREGD CWICMELMST SFDKFYKYVY SVLDDVIPEE
     ILGKITLATV KALNHLKENL KIIHRDIKPS NILLDRSGNI KLCDFGISGQ LVDSIAKTRD
     AGCRPYMAPE RIDPSASRQG YDVRSDVWSL GITLYELATG RFPYPKWNSV FDQLTQVVKG
     DPPQLSNSEE REFSPSFINF VNLCLTKDES KRPKYKELLK HPFILMYEER AVEVACYVCK
     ILDQMPATPS SPMYVD
//

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