(data stored in ACNUC1104 zone)

SWISSPROT: DNAA_RHOE4

ID   DNAA_RHOE4              Reviewed;         520 AA.
AC   C0ZLE1;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   11-DEC-2019, entry version 61.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000255|HAMAP-Rule:MF_00377};
GN   Name=dnaA {ECO:0000255|HAMAP-Rule:MF_00377}; OrderedLocusNames=RER_00010;
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae; Rhodococcus.
OX   NCBI_TaxID=234621;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus erythropolis
RT   PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation of
CC       chromosomal replication. Binds to the origin of replication; it binds
CC       specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC       TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC       {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00377}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00377}.
DR   EMBL; AP008957; BAH30709.1; -; Genomic_DNA.
DR   RefSeq; WP_003942491.1; NC_012490.1.
DR   SMR; C0ZLE1; -.
DR   STRING; 234621.RER_00010; -.
DR   PRIDE; C0ZLE1; -.
DR   EnsemblBacteria; BAH30709; BAH30709; RER_00010.
DR   GeneID; 31539874; -.
DR   KEGG; rer:RER_00010; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000235658; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
DR   PRODOM; C0ZLE1.
DR   SWISS-2DPAGE; C0ZLE1.
KW   ATP-binding; Cytoplasm; DNA replication; DNA-binding; Nucleotide-binding.
FT   CHAIN           1..520
FT                   /note="Chromosomal replication initiator protein DnaA"
FT                   /id="PRO_1000205660"
FT   NP_BIND         221..228
FT                   /note="ATP"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00377"
SQ   SEQUENCE   520 AA;  58241 MW;  82C55421043B5D6B CRC64;
     MNDDPNALAR VWVDVVAELT SDDPGSNLPA LSSKQKAFVR LVRPLTLAQG FALLSVPSPF
     AQETIERDLR EPILQALGRH LGGQVEGLGV RIALEDDADA PAEPVEERTG SRQFESVNSS
     GAYRRRRFTE GDGEPSDSET AETEEVDDDR EALASVHESW PSYFTKPPAT PSASGSGANS
     LNAKYTFDTF VIGSSNRFAH AAAVAIAEAP ARAYNPLFIW GASGLGKTHL LHAAGHYAQR
     LFPGMRVKYV STEEFTNDFI NSLRDDRKVA FKRRYRETDV LLVDDIQFIE GKEGIQEEFF
     HTFNTLHNAN KQIVVSSDRP PKQLATLEER LRTRFEWGLI TDVQPPELET RIAILSKKAR
     MDRLEVPHDV LELIASRIER NIRELEGALI RVTAFASLNR QPLDLTLAEV VLRDLMPDSS
     SLEINAATIM AVTAEYFNMS IDDLCGPGKA RPLAQARQIS MYLCRELTDL SLPKIGQTFG
     RDHTTVMYAD KKIRKEMTER RKVYDQVQEL TARIKQRSKR
//

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