(data stored in ACNUC1104 zone)

SWISSPROT: C0ZLK2_RHOE4

ID   C0ZLK2_RHOE4            Unreviewed;       531 AA.
AC   C0ZLK2;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   SubName: Full=Putative CPA1 family transporter {ECO:0000313|EMBL:BAH30770.1};
GN   OrderedLocusNames=RER_00620 {ECO:0000313|EMBL:BAH30770.1};
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=234621 {ECO:0000313|EMBL:BAH30770.1, ECO:0000313|Proteomes:UP000002204};
RN   [1] {ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus
RT   erythropolis PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAH30770.1, ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RX   PubMed=16423019; DOI=10.1111/j.1462-2920.2005.00899.x;
RA   Sekine M., Tanikawa S., Omata S., Saito M., Fujisawa T., Tsukatani N.,
RA   Tajima T., Sekigawa T., Kosugi H., Matsuo Y., Nishiko R., Imamura K.,
RA   Ito M., Narita H., Tago S., Fujita N., Harayama S.;
RT   "Sequence analysis of three plasmids harboured in Rhodococcus
RT   erythropolis strain PR4.";
RL   Environ. Microbiol. 8:334-346(2006).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000256|RuleBase:RU366002}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU366002}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU366002}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1
CC       (CPA1) transporter (TC 2.A.36) family.
CC       {ECO:0000256|RuleBase:RU366002}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU366002}.
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DR   EMBL; AP008957; BAH30770.1; -; Genomic_DNA.
DR   RefSeq; WP_020905652.1; NC_012490.1.
DR   STRING; 234621.RER_00620; -.
DR   EnsemblBacteria; BAH30770; BAH30770; RER_00620.
DR   KEGG; rer:RER_00620; -.
DR   PATRIC; fig|234621.6.peg.491; -.
DR   eggNOG; ENOG4105EEQ; Bacteria.
DR   eggNOG; COG0025; LUCA.
DR   HOGENOM; HOG000263348; -.
DR   KO; K03316; -.
DR   OMA; AMNDMTR; -.
DR   BioCyc; RERY234621:GHDE-65-MONOMER; -.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   PANTHER; PTHR10110; PTHR10110; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   TIGRFAMs; TIGR00831; a_cpa1; 1.
PE   3: Inferred from homology;
DR   PRODOM; C0ZLK2.
DR   SWISS-2DPAGE; C0ZLK2.
KW   Antiport {ECO:0000256|RuleBase:RU366002};
KW   Cell membrane {ECO:0000256|RuleBase:RU366002};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002204};
KW   Ion transport {ECO:0000256|RuleBase:RU366002};
KW   Membrane {ECO:0000256|RuleBase:RU366002};
KW   Sodium {ECO:0000256|RuleBase:RU366002};
KW   Sodium transport {ECO:0000256|RuleBase:RU366002};
KW   Transmembrane {ECO:0000256|RuleBase:RU366002};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU366002};
KW   Transport {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM     52     74       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM     81    103       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    109    131       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    180    201       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    221    244       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    265    284       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    296    321       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    342    366       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    378    401       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   DOMAIN        7    401       Na_H_Exchanger. {ECO:0000259|Pfam:
FT                                PF00999}.
SQ   SEQUENCE   531 AA;  56278 MW;  5AF1B48D55B867C9 CRC64;
     MNGILLGVVV AALLVAAVAR RFGLSSPLIL VLVGLIACQI PGVPELELDP DLVLFVVLPP
     LLYSAALDSS YLALRSNLRP IGFLAVGLPL ATTAAVGFVA YLIVPEFSIA AALVLGAIVA
     PPDAVSASAI GRKLGLPRRI MTLLGGESLL NDATALTAYK VALAAAVGTG ATLIGGFETF
     LVAAVGGTVI GLAVGFVISK VRGKLQDPVM ESGIGLVVPF FTYLAAEEVH ASGVIAVVVA
     GLFLGQRSTR ASYATRLQDT AVWKAVDLIL ESFVFLLIGL QLPSVVNGLQ GYSTSIVVWA
     SIAVLVTVVV VRIAWVFPFT YVPRWLSPRI RAREPEISAR AVFVVSWAGM RGVVSLAAAF
     AIPLTVNSGE DFPGRSLILF LTFVVVVGTL LLHGLTLPWV IRVLGVQGDE EQSDARAEAA
     AQDKAARAAA ARLDELVGAD ADDVPQVRNR AADILRSWNT HRANSAWERL GRSDEDLGES
     PSNAFRSLRL EMIDAERGVF IAERDAGRID DEVLRKVLRE LDLEEATLDR D
//

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