(data stored in ACNUC1104 zone)

SWISSPROT: C0ZN37_RHOE4

ID   C0ZN37_RHOE4            Unreviewed;       713 AA.
AC   C0ZN37;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 71.
DE   SubName: Full=Fatty oxidation complex alpha subunit {ECO:0000313|EMBL:BAH31089.1};
GN   Name=fadB {ECO:0000313|EMBL:BAH31089.1};
GN   OrderedLocusNames=RER_03810 {ECO:0000313|EMBL:BAH31089.1};
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=234621 {ECO:0000313|EMBL:BAH31089.1, ECO:0000313|Proteomes:UP000002204};
RN   [1] {ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus
RT   erythropolis PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAH31089.1, ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RX   PubMed=16423019; DOI=10.1111/j.1462-2920.2005.00899.x;
RA   Sekine M., Tanikawa S., Omata S., Saito M., Fujisawa T., Tsukatani N.,
RA   Tajima T., Sekigawa T., Kosugi H., Matsuo Y., Nishiko R., Imamura K.,
RA   Ito M., Narita H., Tago S., Fujita N., Harayama S.;
RT   "Sequence analysis of three plasmids harboured in Rhodococcus
RT   erythropolis strain PR4.";
RL   Environ. Microbiol. 8:334-346(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
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DR   EMBL; AP008957; BAH31089.1; -; Genomic_DNA.
DR   RefSeq; WP_003943799.1; NC_012490.1.
DR   STRING; 234621.RER_03810; -.
DR   EnsemblBacteria; BAH31089; BAH31089; RER_03810.
DR   KEGG; rer:RER_03810; -.
DR   PATRIC; fig|234621.6.peg.823; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1024; LUCA.
DR   eggNOG; COG1250; LUCA.
DR   HOGENOM; HOG000261345; -.
DR   KO; K01782; -.
DR   OMA; PFRYMDT; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
DR   PRODOM; C0ZN37.
DR   SWISS-2DPAGE; C0ZN37.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002204};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296}.
FT   DOMAIN      323    501       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      504    604       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   713 AA;  75447 MW;  44CCB9EAEDE1192E CRC64;
     MTDQNIINWD QDADGIVVLT INDPNQGANT MNDAYIASMK ATVDRLVAEK DSITGAVITS
     GKKTFFAGGD LKNMIKVGPE QAEEIYNHSV EIKADLRRLE TLGKPVVAAI NGAALGGGLE
     IALATHHRIA ADVKGVKIGL PEVTLGLLPG GGGVVRTVRM LGLQNALMGV LLQGQQRGPV
     QAKEVGLIDE VVGSVEELVP AAKAWIKANP EGGVQPWDVK GYKIPGGTPS TPAFAANLPA
     FPANLRKQLK GAPMPAPRAI MAAAVEGSQV DIDNALLIEA RYFTSLVTGR VAKNMIQAFF
     FDLQSINGGG SRPAGIEKST IKKVGVLGAG MMGAGIAYVS AKAGFDVVLK DVSIEAANKG
     KAYAEGIEAK ALSRGKTTQE KSDALLAKIT PTADPADFAG VDFVIEAVFE SQELKHKVFQ
     EIEDIVDPKA LLGSNTSTLP ITGLATGVKR QEDFIGIHFF SPVDKMPLVE IIRGEKTSDE
     TLARVFDYVQ AIRKTPIVVN DSRGFFTSRV IGTFINEAIG MLAEGVEPAT IEQAGMQAGY
     PAAPLQLSDE LNLTLMQKIR KESADAAKAE GKELPADPAG EVINTLVEKF DRKGKLGGAG
     FYDYAEGKRT GLWSGLRENF NSGTSDAPIQ DLIDRMLFIE AIETQKCFDE NVLITTADAN
     IGSIMGIGFP AWTGGVHQFI VGYEGGTAGF VARAKELAAQ YGPRFTPPAS LGA
//

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