(data stored in ACNUC1104 zone)

SWISSPROT: C0ZNC9_RHOE4

ID   C0ZNC9_RHOE4            Unreviewed;       173 AA.
AC   C0ZNC9;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   16-JAN-2019, entry version 61.
DE   RecName: Full=3-hydroxyanthranilate 3,4-dioxygenase {ECO:0000256|HAMAP-Rule:MF_00825};
DE            EC=1.13.11.6 {ECO:0000256|HAMAP-Rule:MF_00825};
DE   AltName: Full=3-hydroxyanthranilate oxygenase {ECO:0000256|HAMAP-Rule:MF_00825};
DE            Short=3-HAO {ECO:0000256|HAMAP-Rule:MF_00825};
DE   AltName: Full=3-hydroxyanthranilic acid dioxygenase {ECO:0000256|HAMAP-Rule:MF_00825};
DE            Short=HAD {ECO:0000256|HAMAP-Rule:MF_00825};
GN   Name=nbaC {ECO:0000256|HAMAP-Rule:MF_00825};
GN   OrderedLocusNames=RER_04730 {ECO:0000313|EMBL:BAH31181.1};
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=234621 {ECO:0000313|EMBL:BAH31181.1, ECO:0000313|Proteomes:UP000002204};
RN   [1] {ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus
RT   erythropolis PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAH31181.1, ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RX   PubMed=16423019; DOI=10.1111/j.1462-2920.2005.00899.x;
RA   Sekine M., Tanikawa S., Omata S., Saito M., Fujisawa T., Tsukatani N.,
RA   Tajima T., Sekigawa T., Kosugi H., Matsuo Y., Nishiko R., Imamura K.,
RA   Ito M., Narita H., Tago S., Fujita N., Harayama S.;
RT   "Sequence analysis of three plasmids harboured in Rhodococcus
RT   erythropolis strain PR4.";
RL   Environ. Microbiol. 8:334-346(2006).
CC   -!- FUNCTION: Catalyzes the oxidative ring opening of 3-
CC       hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde,
CC       which spontaneously cyclizes to quinolinate. {ECO:0000256|HAMAP-
CC       Rule:MF_00825}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-
CC         carboxymuconate 6-semialdehyde; Xref=Rhea:RHEA:17953,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:36559, ChEBI:CHEBI:77612;
CC         EC=1.13.11.6; Evidence={ECO:0000256|HAMAP-Rule:MF_00825};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00825};
CC       Note=Binds 2 Fe(2+) ions per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00825};
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate
CC       from L-kynurenine: step 3/3. {ECO:0000256|HAMAP-Rule:MF_00825}.
CC   -!- SIMILARITY: Belongs to the 3-HAO family. {ECO:0000256|HAMAP-
CC       Rule:MF_00825}.
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DR   EMBL; AP008957; BAH31181.1; -; Genomic_DNA.
DR   RefSeq; WP_003943511.1; NC_012490.1.
DR   STRING; 234621.RER_04730; -.
DR   EnsemblBacteria; BAH31181; BAH31181; RER_04730.
DR   GeneID; 31540320; -.
DR   KEGG; rer:RER_04730; -.
DR   PATRIC; fig|234621.6.peg.916; -.
DR   eggNOG; ENOG4105C3W; Bacteria.
DR   eggNOG; ENOG4111GH8; LUCA.
DR   HOGENOM; HOG000218448; -.
DR   KO; K00452; -.
DR   OMA; NARKDYH; -.
DR   UniPathway; UPA00253; UER00330.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0000334; F:3-hydroxyanthranilate 3,4-dioxygenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008198; F:ferrous iron binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0034354; P:'de novo' NAD biosynthetic process from tryptophan; IEA:UniProtKB-UniRule.
DR   GO; GO:0043420; P:anthranilate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0019805; P:quinolinate biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006569; P:tryptophan catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.120.10; -; 1.
DR   HAMAP; MF_00825; 3_HAO; 1.
DR   InterPro; IPR010329; 3hydroanth_dOase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   PANTHER; PTHR15497; PTHR15497; 1.
DR   Pfam; PF06052; 3-HAO; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   TIGRFAMs; TIGR03037; anthran_nbaC; 1.
PE   3: Inferred from homology;
DR   PRODOM; C0ZNC9.
DR   SWISS-2DPAGE; C0ZNC9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002204};
KW   Dioxygenase {ECO:0000256|HAMAP-Rule:MF_00825,
KW   ECO:0000313|EMBL:BAH31181.1}; Iron {ECO:0000256|HAMAP-Rule:MF_00825};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00825};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00825,
KW   ECO:0000313|EMBL:BAH31181.1};
KW   Pyridine nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00825}.
FT   METAL        51     51       Iron 1; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_00825}.
FT   METAL        57     57       Iron 1; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_00825}.
FT   METAL        95     95       Iron 1; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_00825}.
FT   METAL       125    125       Iron 2. {ECO:0000256|HAMAP-Rule:
FT                                MF_00825}.
FT   METAL       128    128       Iron 2. {ECO:0000256|HAMAP-Rule:
FT                                MF_00825}.
FT   METAL       162    162       Iron 2. {ECO:0000256|HAMAP-Rule:
FT                                MF_00825}.
FT   METAL       165    165       Iron 2. {ECO:0000256|HAMAP-Rule:
FT                                MF_00825}.
FT   BINDING      47     47       Dioxygen. {ECO:0000256|HAMAP-Rule:
FT                                MF_00825}.
FT   BINDING      57     57       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00825}.
FT   BINDING      99     99       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00825}.
FT   BINDING     110    110       Substrate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00825}.
SQ   SEQUENCE   173 AA;  19906 MW;  4591642EF9331E87 CRC64;
     MTTIPPVIDF KKWIDDNRHL LQPPVNNQTM ALGDDFIVQV VGGPNQRTDY HLDPYEEWFY
     QLEGDIHVNV MTEDGPQRVD IREGETWLLP GDIPHSPQRP TAGSIGLVIE RVRKEGTLEK
     FQWYCLECDH KIHEVELQVR DIVADLPPVF VKFYESEEAR TCDKCGTLHP GKG
//

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