(data stored in ACNUC7421 zone)

SWISSPROT: C1AS20_RHOOB

ID   C1AS20_RHOOB            Unreviewed;       433 AA.
AC   C1AS20;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   07-JUN-2017, entry version 55.
DE   RecName: Full=Na(+)/H(+) antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
DE   AltName: Full=Sodium/proton antiporter NhaA {ECO:0000256|HAMAP-Rule:MF_01844};
GN   Name=nhaA {ECO:0000256|HAMAP-Rule:MF_01844,
GN   ECO:0000313|EMBL:BAH48269.1};
GN   OrderedLocusNames=ROP_00220 {ECO:0000313|EMBL:BAH48269.1};
OS   Rhodococcus opacus (strain B4).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=632772 {ECO:0000313|EMBL:BAH48269.1, ECO:0000313|Proteomes:UP000002212};
RN   [1] {ECO:0000313|EMBL:BAH48269.1, ECO:0000313|Proteomes:UP000002212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4 {ECO:0000313|EMBL:BAH48269.1,
RC   ECO:0000313|Proteomes:UP000002212};
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus
RT   erythropolis PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000256|HAMAP-Rule:MF_01844,
CC       ECO:0000256|SAAS:SAAS00693862}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01844}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01844}.
CC   -!- SIMILARITY: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter
CC       family. {ECO:0000256|HAMAP-Rule:MF_01844,
CC       ECO:0000256|SAAS:SAAS00693876}.
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DR   EMBL; AP011115; BAH48269.1; -; Genomic_DNA.
DR   STRING; 632772.ROP_00220; -.
DR   EnsemblBacteria; BAH48269; BAH48269; ROP_00220.
DR   KEGG; rop:ROP_00220; -.
DR   PATRIC; fig|632772.20.peg.25; -.
DR   eggNOG; ENOG4105DRC; Bacteria.
DR   eggNOG; COG3004; LUCA.
DR   HOGENOM; HOG000218489; -.
DR   KO; K03313; -.
DR   OMA; LTWTHIT; -.
DR   OrthoDB; POG091H05CU; -.
DR   Proteomes; UP000002212; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 1.20.1530.10; -; 1.
DR   HAMAP; MF_01844; NhaA; 1.
DR   InterPro; IPR023171; Na/H_antiporter_dom.
DR   InterPro; IPR004670; NhaA.
DR   PANTHER; PTHR30341:SF2; PTHR30341:SF2; 1.
DR   Pfam; PF06965; Na_H_antiport_1; 1.
DR   TIGRFAMs; TIGR00773; NhaA; 1.
PE   3: Inferred from homology;
DR   PRODOM; C1AS20.
DR   SWISS-2DPAGE; C1AS20.
KW   Antiport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693867};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693865};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002212};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693875};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693879};
KW   Sodium {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693859};
KW   Sodium transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693872};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693873};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693863};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01844,
KW   ECO:0000256|SAAS:SAAS00693869}.
FT   TRANSMEM     31     49       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM     69     91       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    111    131       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    143    165       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    172    192       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    198    215       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    222    237       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    243    261       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    282    303       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    315    338       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    350    376       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
FT   TRANSMEM    388    407       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01844}.
SQ   SEQUENCE   433 AA;  45595 MW;  B947AC284F6CA8C7 CRC64;
     MMNAPLSRLP LLSRGSWPET ARVAEILRKE TVGGVLLLIA AAAALIWANT PWSDAYHSLR
     EVTVGPPSLH LNLTLGTWAA DGLLAIFFFV VGLELKREFV AGDLRDPRRA ALPVMAAIGG
     MIAPALIFVA INLGTGGGAL NGWAIPTATD IAFAVAILAV IGTHLPAALR TFLLTLAVVD
     DLLAVTVIAI FYTDDLDFTY LGLALIPLAA FGFAVQKRIR SFWILLPLAA ATWWLVHESG
     VHATIAGVLL GFTVPVVRSA AAGGPDAGPG LAEHFEHRIR PLSAGFAVPV FAFFAAGVTI
     GGLDGFVDTL GDRVALGIVA GLVIGKVVGI TGMSVLIAKF TRAELDEDLS WLDVIAVAML
     GGIGFTVSLL IGELAFAGDV LRSDHVKIGV LTGTLTAALL AAILLRLRNR AYRRIADRET
     ADMNHDGIPD IYQ
//

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