(data stored in ACNUC7421 zone)

SWISSPROT: TRPC_RHOOB

ID   TRPC_RHOOB              Reviewed;         269 AA.
AC   C1AT55;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 59.
DE   RecName: Full=Indole-3-glycerol phosphate synthase {ECO:0000255|HAMAP-Rule:MF_00134};
DE            Short=IGPS {ECO:0000255|HAMAP-Rule:MF_00134};
DE            EC=4.1.1.48 {ECO:0000255|HAMAP-Rule:MF_00134};
GN   Name=trpC {ECO:0000255|HAMAP-Rule:MF_00134};
GN   OrderedLocusNames=ROP_07400;
OS   Rhodococcus opacus (strain B4).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=632772;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus
RT   erythropolis PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate +
CC         H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O;
CC         Xref=Rhea:RHEA:23476, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:58613, ChEBI:CHEBI:58866;
CC         EC=4.1.1.48; Evidence={ECO:0000255|HAMAP-Rule:MF_00134};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5. {ECO:0000255|HAMAP-
CC       Rule:MF_00134}.
CC   -!- SIMILARITY: Belongs to the TrpC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00134}.
DR   EMBL; AP011115; BAH48987.1; -; Genomic_DNA.
DR   RefSeq; WP_012687986.1; NC_012522.1.
DR   SMR; C1AT55; -.
DR   EnsemblBacteria; BAH48987; BAH48987; ROP_07400.
DR   KEGG; rop:ROP_07400; -.
DR   PATRIC; fig|632772.20.peg.803; -.
DR   eggNOG; ENOG4105DK0; Bacteria.
DR   eggNOG; COG0134; LUCA.
DR   HOGENOM; HOG000230462; -.
DR   KO; K01609; -.
DR   OMA; RKDFMVD; -.
DR   OrthoDB; 1789381at2; -.
DR   UniPathway; UPA00035; UER00043.
DR   Proteomes; UP000002212; Chromosome.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00331; IGPS; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_00134_A; IGPS_A; 1.
DR   HAMAP; MF_00134_B; IGPS_B; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth.
DR   InterPro; IPR001468; Indole-3-GlycerolPSynthase_CS.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00218; IGPS; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
DR   PRODOM; C1AT55.
DR   SWISS-2DPAGE; C1AT55.
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Decarboxylase; Lyase; Tryptophan biosynthesis.
FT   CHAIN         1    269       Indole-3-glycerol phosphate synthase.
FT                                /FTId=PRO_1000198785.
SQ   SEQUENCE   269 AA;  27541 MW;  A25119A39BCBBF1F CRC64;
     MTVLDSILDG VRADVAAREA VLDFAAVKAA AAAAPPALDA AAALLEPGIG VIAEVKRASP
     SKGALADIAD PAELAAAYQA GGARVISVLT EERRFQGSLA DLDAVRRAVS IPILRKDFIV
     GPYQIHEARA HGADMVLLIV AALEQDALAS LIDRTESLGM TALVEVHTEE EANRAIEAGA
     KVIGVNARNL KTLEVDKNTF GEIAPGLPTE IIKIAESGVR GTADLLAYAG AGADAVLVGE
     GLVTSGDPRK AVADLVNAGA HPSCPKPSR
//

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