(data stored in ACNUC7421 zone)

SWISSPROT: HIS6_RHOOB

ID   HIS6_RHOOB              Reviewed;         257 AA.
AC   C1ATY7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   07-JUN-2017, entry version 50.
DE   RecName: Full=Imidazole glycerol phosphate synthase subunit HisF {ECO:0000255|HAMAP-Rule:MF_01013};
DE            EC=4.1.3.- {ECO:0000255|HAMAP-Rule:MF_01013};
DE   AltName: Full=IGP synthase cyclase subunit {ECO:0000255|HAMAP-Rule:MF_01013};
DE   AltName: Full=IGP synthase subunit HisF {ECO:0000255|HAMAP-Rule:MF_01013};
DE   AltName: Full=ImGP synthase subunit HisF {ECO:0000255|HAMAP-Rule:MF_01013};
DE            Short=IGPS subunit HisF {ECO:0000255|HAMAP-Rule:MF_01013};
GN   Name=hisF {ECO:0000255|HAMAP-Rule:MF_01013};
GN   OrderedLocusNames=ROP_07480;
OS   Rhodococcus opacus (strain B4).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=632772;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B4;
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus
RT   erythropolis PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to
CC       IGP, AICAR and glutamate. The HisF subunit catalyzes the
CC       cyclization activity that produces IGP and AICAR from PRFAR using
CC       the ammonia provided by the HisH subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01013}.
CC   -!- CATALYTIC ACTIVITY: 5-[(5-phospho-1-deoxyribulos-1-
CC       ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-
CC       carboxamide + L-glutamine = imidazole-glycerol phosphate + 5-
CC       aminoimidazol-4-carboxamide ribonucleotide + L-glutamate + H(2)O.
CC       {ECO:0000255|HAMAP-Rule:MF_01013}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-
CC       histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
CC       {ECO:0000255|HAMAP-Rule:MF_01013}.
CC   -!- SUBUNIT: Heterodimer of HisH and HisF. {ECO:0000255|HAMAP-
CC       Rule:MF_01013}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01013}.
CC   -!- SIMILARITY: Belongs to the HisA/HisF family. {ECO:0000255|HAMAP-
CC       Rule:MF_01013}.
DR   EMBL; AP011115; BAH48995.1; -; Genomic_DNA.
DR   RefSeq; WP_012687994.1; NC_012522.1.
DR   ProteinModelPortal; C1ATY7; -.
DR   SMR; C1ATY7; -.
DR   STRING; 632772.ROP_07480; -.
DR   EnsemblBacteria; BAH48995; BAH48995; ROP_07480.
DR   KEGG; rop:ROP_07480; -.
DR   PATRIC; fig|632772.20.peg.811; -.
DR   eggNOG; ENOG4105C0S; Bacteria.
DR   eggNOG; COG0107; LUCA.
DR   HOGENOM; HOG000224612; -.
DR   KO; K02500; -.
DR   OMA; KRIVPCL; -.
DR   OrthoDB; POG091H06EY; -.
DR   UniPathway; UPA00031; UER00010.
DR   Proteomes; UP000002212; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000107; F:imidazoleglycerol-phosphate synthase activity; IEA:InterPro.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04731; HisF; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   HAMAP; MF_01013; HisF; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006062; His_biosynth.
DR   InterPro; IPR004651; HisF.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00977; His_biosynth; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   TIGRFAMs; TIGR00735; hisF; 1.
PE   3: Inferred from homology;
DR   PRODOM; C1ATY7.
DR   SWISS-2DPAGE; C1ATY7.
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm;
KW   Histidine biosynthesis; Lyase.
FT   CHAIN         1    257       Imidazole glycerol phosphate synthase
FT                                subunit HisF.
FT                                /FTId=PRO_1000148936.
FT   ACT_SITE     12     12       {ECO:0000255|HAMAP-Rule:MF_01013}.
FT   ACT_SITE    131    131       {ECO:0000255|HAMAP-Rule:MF_01013}.
SQ   SEQUENCE   257 AA;  26688 MW;  3889EF4DFE2BD8C0 CRC64;
     MTLAVRVIPC LDVDAGRVVK GVNFENLRDA GDPVELAAAY DAQGADELTF LDVTASTADR
     GTMLDVVSRT AEQVFIPLTV GGGVRTVEDV DRLLRAGADK VSVNTAAIAR PELLRELSER
     FGSQCIVLSV DARTVPQGQP DTPSGWEVTT HGGKRGTGID AVEWAVRGAE LGVGEILLNS
     MDADGTKAGF DLPMIRAVRA AVHVPVIASG GAGAVEHFAP AVGAGADAVL AASVFHFGDM
     TIGDVKKSMR AEGITVR
//

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