(data stored in ACNUC10821 zone)

SWISSPROT: C8U1G9_ECO10

ID   C8U1G9_ECO10            Unreviewed;       170 AA.
AC   C8U1G9;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-MAY-2019, entry version 49.
DE   RecName: Full=Secretion monitor {ECO:0000256|HAMAP-Rule:MF_01332};
DE   Flags: Precursor;
GN   Name=secM {ECO:0000256|HAMAP-Rule:MF_01332,
GN   ECO:0000313|EMBL:BAI28977.1};
GN   OrderedLocusNames=ECO103_0099 {ECO:0000313|EMBL:BAI28977.1};
OS   Escherichia coli O103:H2 (strain 12009 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585395 {ECO:0000313|EMBL:BAI28977.1, ECO:0000313|Proteomes:UP000000959};
RN   [1] {ECO:0000313|EMBL:BAI28977.1, ECO:0000313|Proteomes:UP000000959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12009 / EHEC {ECO:0000313|Proteomes:UP000000959};
RX   PubMed=19815525; DOI=10.1073/pnas.0903585106;
RA   Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K.,
RA   Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M.,
RA   Hayashi T.;
RT   "Comparative genomics reveal the mechanism of the parallel evolution
RT   of O157 and non-O157 enterohemorrhagic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009).
CC   -!- FUNCTION: Regulates secA expression by translational coupling of
CC       the secM secA operon. Translational pausing at a specific Pro
CC       residue 5 residues before the end of the protein may allow
CC       disruption of a mRNA repressor helix that normally suppresses secA
CC       translation initiation. {ECO:0000256|HAMAP-Rule:MF_01332}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000256|HAMAP-
CC       Rule:MF_01332}. Periplasm {ECO:0000256|HAMAP-Rule:MF_01332}.
CC       Note=The active form is cytosolic, while the periplasmic form is
CC       rapidly degraded, mainly by the tail-specific protease.
CC       {ECO:0000256|HAMAP-Rule:MF_01332}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000256|HAMAP-
CC       Rule:MF_01332}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AP010958; BAI28977.1; -; Genomic_DNA.
DR   RefSeq; WP_000014321.1; NC_013353.1.
DR   SMR; C8U1G9; -.
DR   EnsemblBacteria; BAI28977; BAI28977; ECO103_0099.
DR   KEGG; eoh:ECO103_0099; -.
DR   HOGENOM; HOG000267813; -.
DR   KO; K13301; -.
DR   OMA; NYWQQHA; -.
DR   BioCyc; ECOL585395:ECO103_RS00500-MONOMER; -.
DR   Proteomes; UP000000959; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
DR   PIRSF; PIRSF004572; SecM; 1.
DR   ProDom; PD089227; SecM; 1.
PE   3: Inferred from homology;
DR   PRODOM; C8U1G9.
DR   SWISS-2DPAGE; C8U1G9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000959};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01332};
KW   Periplasm {ECO:0000256|HAMAP-Rule:MF_01332};
KW   Signal {ECO:0000256|HAMAP-Rule:MF_01332}.
FT   SIGNAL        1     37       {ECO:0000256|HAMAP-Rule:MF_01332}.
FT   CHAIN        38    170       Secretion monitor. {ECO:0000256|HAMAP-
FT                                Rule:MF_01332}.
FT                                /FTId=PRO_5009008807.
SQ   SEQUENCE   170 AA;  18880 MW;  5F5B3001056CAD22 CRC64;
     MSGILTRWRQ FGKRYFWPHL LLGMVAASLG LPALSNAAEP NAPAKATTRN HEPSAKVNFG
     QLALLEANTR RPNSNYSVDY WHQHAIRTVI RHLSFAMAPQ TLPVAEESLP LQAQHLALLD
     TLSALLTQEG TPSEKGYRID YAHFTPQAKF STPVWISQAQ GIRAGPQRLT
//

If you have problems or comments...

PBIL Back to PBIL home page