(data stored in ACNUC10821 zone)

SWISSPROT: C8U1H6_ECO10

ID   C8U1H6_ECO10            Unreviewed;       400 AA.
AC   C8U1H6;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-MAY-2019, entry version 51.
DE   SubName: Full=Assembly protein HofC in type IV pilin biogenesis, transmembrane protein {ECO:0000313|EMBL:BAI28984.1};
GN   Name=hofC {ECO:0000313|EMBL:BAI28984.1};
GN   Synonyms=hcpA {ECO:0000313|EMBL:BAI28984.1};
GN   OrderedLocusNames=ECO103_0106 {ECO:0000313|EMBL:BAI28984.1};
OS   Escherichia coli O103:H2 (strain 12009 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585395 {ECO:0000313|EMBL:BAI28984.1, ECO:0000313|Proteomes:UP000000959};
RN   [1] {ECO:0000313|EMBL:BAI28984.1, ECO:0000313|Proteomes:UP000000959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12009 / EHEC {ECO:0000313|Proteomes:UP000000959};
RX   PubMed=19815525; DOI=10.1073/pnas.0903585106;
RA   Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K.,
RA   Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M.,
RA   Hayashi T.;
RT   "Comparative genomics reveal the mechanism of the parallel evolution
RT   of O157 and non-O157 enterohemorrhagic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU003923}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU003923}.
CC   -!- SIMILARITY: Belongs to the GSP F family.
CC       {ECO:0000256|RuleBase:RU003923}.
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DR   EMBL; AP010958; BAI28984.1; -; Genomic_DNA.
DR   RefSeq; WP_000157234.1; NC_013353.1.
DR   EnsemblBacteria; BAI28984; BAI28984; ECO103_0106.
DR   KEGG; eoh:ECO103_0106; -.
DR   HOGENOM; HOG000253740; -.
DR   KO; K02505; -.
DR   OMA; PLYLAMI; -.
DR   BioCyc; ECOL585395:ECO103_RS00540-MONOMER; -.
DR   Proteomes; UP000000959; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 1.20.81.30; -; 2.
DR   InterPro; IPR003004; GspF/PilC.
DR   InterPro; IPR018076; T2SS_F.
DR   InterPro; IPR042094; T2SS_F_sf.
DR   InterPro; IPR001992; Type_2_secretion_system_CS.
DR   PANTHER; PTHR30012; PTHR30012; 1.
DR   Pfam; PF00482; T2SSF; 2.
DR   PRINTS; PR00812; BCTERIALGSPF.
DR   PROSITE; PS00874; T2SP_F; 1.
PE   3: Inferred from homology;
DR   PRODOM; C8U1H6.
DR   SWISS-2DPAGE; C8U1H6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000959};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|RuleBase:RU003923, ECO:0000256|SAM:Phobius,
KW   ECO:0000313|EMBL:BAI28984.1};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003923}.
FT   TRANSMEM    162    185       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    216    234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    369    389       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       64    186       T2SSF. {ECO:0000259|Pfam:PF00482}.
FT   DOMAIN      269    388       T2SSF. {ECO:0000259|Pfam:PF00482}.
SQ   SEQUENCE   400 AA;  44415 MW;  4AF8A740CD821F5B CRC64;
     MASKQLWRWH GITGDGNAQD GMLWAESRAL LLMALQQQMV TPLSLKRIAI NSAQWRGDKS
     AEVIHQLATL LKAGLTLSEG LALLAEQHPS KQWQALLQSL AHDLEQGIAF SNALLPWSEV
     FPPLYQAMIR TGELTGKLDE CCFELARQQK AQRQLTDKVK SALRYPIIIL AMAIMVVVAM
     LHFVLPEFAA IYKTFNTPLP ALTQGIMTLA DFSGEWSWLL VLFGFLLAIA NKLLMRRPTW
     LIVRQKLLLR IPIMGSLMRG QKLTQIFTIL ALTQSAGITF LQGVESVRET MRCPYWVQLL
     TQIQHDISNG HPIWLALKNT GEFSPLCLQL VRTGEASGSL DLMLDNLAHH HRDNTMALAD
     NLAALLEPAL LIITGGIIGT LVVAMYLPIF HLGDAMSGMG
//

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