(data stored in ACNUC10821 zone)

SWISSPROT: C8U1Z2_ECO10

ID   C8U1Z2_ECO10            Unreviewed;       289 AA.
AC   C8U1Z2;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-MAY-2019, entry version 49.
DE   SubName: Full=Putative reductase {ECO:0000313|EMBL:BAI29150.1};
GN   OrderedLocusNames=ECO103_0277 {ECO:0000313|EMBL:BAI29150.1};
OS   Escherichia coli O103:H2 (strain 12009 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585395 {ECO:0000313|EMBL:BAI29150.1, ECO:0000313|Proteomes:UP000000959};
RN   [1] {ECO:0000313|EMBL:BAI29150.1, ECO:0000313|Proteomes:UP000000959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12009 / EHEC {ECO:0000313|Proteomes:UP000000959};
RX   PubMed=19815525; DOI=10.1073/pnas.0903585106;
RA   Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K.,
RA   Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M.,
RA   Hayashi T.;
RT   "Comparative genomics reveal the mechanism of the parallel evolution
RT   of O157 and non-O157 enterohemorrhagic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009).
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DR   EMBL; AP010958; BAI29150.1; -; Genomic_DNA.
DR   SMR; C8U1Z2; -.
DR   EnsemblBacteria; BAI29150; BAI29150; ECO103_0277.
DR   KEGG; eoh:ECO103_0277; -.
DR   HOGENOM; HOG000250272; -.
DR   OMA; IVPMITV; -.
DR   Proteomes; UP000000959; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd06660; Aldo_ket_red; 1.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR020471; Aldo/keto_reductase.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
DR   PRODOM; C8U1Z2.
DR   SWISS-2DPAGE; C8U1Z2.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000959}.
FT   DOMAIN       22    262       Aldo_ket_red. {ECO:0000259|Pfam:PF00248}.
FT   ACT_SITE     49     49       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000097-1}.
FT   BINDING     112    112       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000097-2}.
FT   SITE         78     78       Lowers pKa of active site Tyr.
FT                                {ECO:0000256|PIRSR:PIRSR000097-3}.
SQ   SEQUENCE   289 AA;  32703 MW;  687C30E363AE92B1 CRC64;
     MEFSVLSNNL KMPMMGFGVF QVTDKNVCKQ SVLNAIRTGY RLIDTAAVYG NEDAVGEAVR
     EAISEGLCTR DELFITSKLW VQDMLNQDTA AAGIEASLKK SGLEYFDLYL LHQAMRDYFS
     AWRALEDAYE EGKLKAIGVS NFYPHVLAKF CETVRVKPMV NQVELHPYFA QPEALATMKY
     YNVQPEAWAP LGGGRHKPFE NNLLQSIADA HQKSISQVIL RWNIQRGVVV IPKSTHQQRI
     EENFAIWDFS LTEKEMAQIS SLDLGYVGES VKHFNPEFVR GCLAVKIHD
//

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