(data stored in ACNUC10821 zone)

SWISSPROT: C8U2F1_ECO10

ID   C8U2F1_ECO10            Unreviewed;      1120 AA.
AC   C8U2F1;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   08-MAY-2019, entry version 49.
DE   SubName: Full=Mechanosensitive channel protein {ECO:0000313|EMBL:BAI29309.1};
GN   Name=kefA {ECO:0000313|EMBL:BAI29309.1};
GN   OrderedLocusNames=ECO103_0441 {ECO:0000313|EMBL:BAI29309.1};
OS   Escherichia coli O103:H2 (strain 12009 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585395 {ECO:0000313|EMBL:BAI29309.1, ECO:0000313|Proteomes:UP000000959};
RN   [1] {ECO:0000313|EMBL:BAI29309.1, ECO:0000313|Proteomes:UP000000959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12009 / EHEC {ECO:0000313|Proteomes:UP000000959};
RX   PubMed=19815525; DOI=10.1073/pnas.0903585106;
RA   Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K.,
RA   Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M.,
RA   Hayashi T.;
RT   "Comparative genomics reveal the mechanism of the parallel evolution
RT   of O157 and non-O157 enterohemorrhagic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009).
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DR   EMBL; AP010958; BAI29309.1; -; Genomic_DNA.
DR   RefSeq; WP_000177726.1; NC_013353.1.
DR   EnsemblBacteria; BAI29309; BAI29309; ECO103_0441.
DR   KEGG; eoh:ECO103_0441; -.
DR   HOGENOM; HOG000280842; -.
DR   KO; K05802; -.
DR   OMA; GQLINWS; -.
DR   BioCyc; ECOL585395:ECO103_RS02305-MONOMER; -.
DR   Proteomes; UP000000959; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 2.30.30.60; -; 1.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR011066; MscC_channel_C.
DR   InterPro; IPR006685; MscS_channel.
DR   InterPro; IPR006686; MscS_channel_CS.
DR   InterPro; IPR011014; MscS_channel_TM-2.
DR   InterPro; IPR023408; MscS_dom_sf.
DR   InterPro; IPR025692; MscS_IM_dom1.
DR   InterPro; IPR024393; MscS_porin.
DR   Pfam; PF00924; MS_channel; 1.
DR   Pfam; PF12795; MscS_porin; 1.
DR   Pfam; PF12794; MscS_TM; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
DR   SUPFAM; SSF81665; SSF81665; 1.
DR   SUPFAM; SSF82689; SSF82689; 1.
DR   SUPFAM; SSF82861; SSF82861; 1.
DR   PROSITE; PS01246; UPF0003; 1.
PE   4: Predicted;
DR   PRODOM; C8U2F1.
DR   SWISS-2DPAGE; C8U2F1.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000959};
KW   Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     33       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        34   1120       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002992714.
FT   TRANSMEM    499    522       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    560    579       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    585    606       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    630    646       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    658    679       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    691    716       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    728    747       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    796    820       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    840    860       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    881    902       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    914    942       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       50    289       MscS_porin. {ECO:0000259|Pfam:PF12795}.
FT   DOMAIN      509    826       MscS_TM. {ECO:0000259|Pfam:PF12794}.
FT   COILED       44     64       {ECO:0000256|SAM:Coils}.
FT   COILED      130    164       {ECO:0000256|SAM:Coils}.
FT   COILED      362    382       {ECO:0000256|SAM:Coils}.
FT   COILED     1061   1081       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1120 AA;  127232 MW;  C244689B143F5221 CRC64;
     MTMFQYYKRS RHFVFSAFIA FVFVLLCQNT AFARASSNGD LPTKADLQAQ LDSLNKQKDL
     SAQDKLVQQD LTDTLATLDK IDRIKEETVQ LRQKVAEAPE KMRQATAALT ALSDVDNDEE
     TRKILSTLSL RQLETRVAQA LDDLQNAQND LASYNSQLVS LQTQPERVQN AMYNASQQLQ
     QIRSRLDGTD VGETALRPSQ KVLMQAQQAL LNAEIDQQRK SLEGNTVLQD TLQKQRDYVT
     ANSARLEHQL QLLQEAVNSK RLTLTEKTAQ EAVSPDEAAR IQANPLVKQE LEINQQLSQR
     LITATENGNQ LMQQNIKVKN WLERALQSER NIKEQIAVLK GSLLLSRILY QQQQTLPSAD
     ELENMTNRIA DLRLEQFEVN QQRDALFQSD AFVNKLEEGH TNEVNSEVHD ALLQVVDMRR
     ELLDQLNKQL GNQLMMAINL QINQQQLMSV SKNLKSILTQ QIFWVNSNRP MDWDWIKAFP
     QSLKDEFKSM KITVNWEKAW PAVFIAFLAG LPLLLIAGLI HWRLGWLKAY QQKLASAVGS
     LRNDSQLNTP KAILIDLIRA LPVCLIILAV GLILLTMQLN ISELLWSFSK KLAIFWLVFG
     LCWKVLEKNG VAVRHFGMPE QQTSHWRRQI VRISLALLPI HFWSVVAELS PLHLMDDVLG
     QAMIFFNLLL IAFLVWPMCR ESWRDKESHT MRLVTITVLS IIPIALMVLT ATGYFYTTLR
     LSGRWIETVY LVIIWNLLYQ TVLRGLSVAA RRIAWRRALA RRQNLVKEGA EGAEPPEEPT
     IALEQVNQQT LRITMLLMFA LFGVMFWAIW SDLITVFSYL DSITLWHYNG TEAGAAVVKN
     VTMGSLLFAI IASMVAWALI RNLPGLLEVL VLSRLNMRQG ASYAITTILN YIIIAVGAMT
     VFGSLGVSWD KLQWLAAALS VGLGFGLQEI FGNFVSGLII LFERPVRIGD TVTIGSFSGT
     VSKIRIRATT ITDFDRKEVI IPNKAFVTER LINWSLTDTT TRLVIRLGVA YGSDLEKVRK
     VLLKAATEHP RVMHEPMPEV FFTAFGASTL DHELRLYVRE LRDRSRTVDE LNRTIDQLCR
     ENDINIAFNQ LEVHLHNEKG DEVTEVKRDY KGDDPTPAVG
//

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