(data stored in ACNUC10821 zone)

SWISSPROT: C8U2T1_ECO10

ID   C8U2T1_ECO10            Unreviewed;       482 AA.
AC   C8U2T1;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   16-JAN-2019, entry version 67.
DE   RecName: Full=Sensor protein {ECO:0000256|RuleBase:RU364088};
DE            EC=2.7.13.3 {ECO:0000256|RuleBase:RU364088};
GN   Name=cusS {ECO:0000313|EMBL:BAI29439.1};
GN   OrderedLocusNames=ECO103_0575 {ECO:0000313|EMBL:BAI29439.1};
OS   Escherichia coli O103:H2 (strain 12009 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=585395 {ECO:0000313|EMBL:BAI29439.1, ECO:0000313|Proteomes:UP000000959};
RN   [1] {ECO:0000313|EMBL:BAI29439.1, ECO:0000313|Proteomes:UP000000959}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12009 / EHEC {ECO:0000313|Proteomes:UP000000959};
RX   PubMed=19815525; DOI=10.1073/pnas.0903585106;
RA   Ogura Y., Ooka T., Iguchi A., Toh H., Asadulghani M., Oshima K.,
RA   Kodama T., Abe H., Nakayama K., Kurokawa K., Tobe T., Hattori M.,
RA   Hayashi T.;
RT   "Comparative genomics reveal the mechanism of the parallel evolution
RT   of O157 and non-O157 enterohemorrhagic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:17939-17944(2009).
CC   -!- FUNCTION: Member of a two-component regulatory system.
CC       {ECO:0000256|RuleBase:RU364088}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|RuleBase:RU364088,
CC         ECO:0000256|SAAS:SAAS01126420};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU364088}.
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DR   EMBL; AP010958; BAI29439.1; -; Genomic_DNA.
DR   RefSeq; WP_000253825.1; NC_013353.1.
DR   EnsemblBacteria; BAI29439; BAI29439; ECO103_0575.
DR   KEGG; eoh:ECO103_0575; -.
DR   HOGENOM; HOG000126763; -.
DR   KO; K07644; -.
DR   OMA; ITETAQF; -.
DR   BioCyc; ECOL585395:ECO103_RS03000-MONOMER; -.
DR   Proteomes; UP000000959; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR006290; CztS_silS_copS.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR01386; cztS_silS_copS; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; C8U2T1.
DR   SWISS-2DPAGE; C8U2T1.
KW   ATP-binding {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00925949};
KW   Cell inner membrane {ECO:0000256|RuleBase:RU364088};
KW   Cell membrane {ECO:0000256|RuleBase:RU364088};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000959};
KW   Kinase {ECO:0000256|RuleBase:RU364088, ECO:0000256|SAAS:SAAS01003914,
KW   ECO:0000313|EMBL:BAI29439.1};
KW   Membrane {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00925724};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00925310};
KW   Transferase {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00926038};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00926160};
KW   Two-component regulatory system {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     12     36       Helical. {ECO:0000256|RuleBase:RU364088}.
FT   TRANSMEM    187    206       Helical. {ECO:0000256|RuleBase:RU364088}.
FT   DOMAIN      207    260       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      268    482       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   482 AA;  54104 MW;  0E6DA369ACA4730B CRC64;
     MVSKPFQRPF SLATRLTFFI SLATIAAFFA FAWIMIHSVK VHFAEQDIND LKEISATLER
     VLNHPDETQA RRLMTLEDIV SGYSNVLISL ADSHGKTVYH SPGAPDIREF TRDAIPDKDA
     RGGEVYLLSG PTIMMPGHGH GHMEHSNWRM INLSVGPLVD GKPIYTLYIA LSIDFHLHYI
     NDLMNKLIMT ASIISILIVF IVLLAVHKGH APIRSVSRQI QNITSKDLDV RLDPQTVPIE
     LEQLVLSFNH MIERIEDVFT RQSNFSADIA HEIRTPITNL ITQTEIALSQ SRSQKELEDV
     LYSNLEELTR MAKMVSDMLF LAQADNNQLI PEKKMLNLAD EVGKVFDFFE ALAEDRGVEL
     RFVGDECQVA GDPLMLRRAL SNLLSNALRY TPPGEAIVVR CQTVDHQVQV TVENPGTPIA
     PEHLPRLFDR FYRVDPSRQR KGEGSGIGLA IVKSIVVAHK GTVAVTSDAR GTRFVIMLPE
     RE
//

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