(data stored in ACNUC10043 zone)

SWISSPROT: D1YUF8_METPS

ID   D1YUF8_METPS            Unreviewed;       347 AA.
AC   D1YUF8;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   11-DEC-2019, entry version 53.
DE   RecName: Full=Signal recognition particle receptor FtsY {ECO:0000256|HAMAP-Rule:MF_00920};
DE            Short=SRP receptor {ECO:0000256|HAMAP-Rule:MF_00920};
GN   Name=ftsY {ECO:0000256|HAMAP-Rule:MF_00920};
GN   OrderedLocusNames=MCP_0008 {ECO:0000313|EMBL:BAI60080.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI60080.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT   paludicola, the first cultivated representative of the order
RT   Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
CC   -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC       proteins into the cytoplasmic membrane. Acts as a receptor for the
CC       complex formed by the signal recognition particle (SRP) and the
CC       ribosome-nascent chain (RNC). {ECO:0000256|HAMAP-Rule:MF_00920}.
CC   -!- SUBUNIT: Part of the signal recognition particle protein translocation
CC       system, which is composed of SRP and FtsY. {ECO:0000256|HAMAP-
CC       Rule:MF_00920}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00920};
CC       Peripheral membrane protein {ECO:0000256|HAMAP-Rule:MF_00920};
CC       Cytoplasmic side {ECO:0000256|HAMAP-Rule:MF_00920}. Cytoplasm
CC       {ECO:0000256|HAMAP-Rule:MF_00920}.
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. FtsY subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_00920}.
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DR   EMBL; AP011532; BAI60080.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_0008; -.
DR   EnsemblBacteria; BAI60080; BAI60080; MCP_0008.
DR   KEGG; mpd:MCP_0008; -.
DR   PATRIC; fig|304371.9.peg.8; -.
DR   eggNOG; arCOG01227; Archaea.
DR   eggNOG; COG0552; LUCA.
DR   HOGENOM; HOG000036277; -.
DR   KO; K03110; -.
DR   OMA; GISDQFQ; -.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0031226; C:intrinsic component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro.
DR   Gene3D; 1.20.120.140; -; 1.
DR   HAMAP; MF_00920; FtsY; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013822; Signal_recog_particl_SRP54_hlx.
DR   InterPro; IPR004390; SR_rcpt_FtsY.
DR   InterPro; IPR036225; SRP/SRP_N.
DR   InterPro; IPR000897; SRP54_GTPase_dom.
DR   InterPro; IPR042101; SRP54_N_sf.
DR   Pfam; PF00448; SRP54; 1.
DR   Pfam; PF02881; SRP54_N; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00962; SRP54; 1.
DR   SMART; SM00963; SRP54_N; 1.
DR   SUPFAM; SSF47364; SSF47364; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00064; ftsY; 1.
DR   PROSITE; PS00300; SRP54; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1YUF8.
DR   SWISS-2DPAGE; D1YUF8.
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00920};
KW   GTP-binding {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00920};
KW   Receptor {ECO:0000256|HAMAP-Rule:MF_00920, ECO:0000313|EMBL:BAI60080.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001882}.
FT   DOMAIN          319..332
FT                   /note="SRP54"
FT                   /evidence="ECO:0000259|PROSITE:PS00300"
FT   NP_BIND         158..165
FT                   /note="GTP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00920"
FT   NP_BIND         240..244
FT                   /note="GTP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00920"
FT   NP_BIND         298..301
FT                   /note="GTP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00920"
FT   REGION          16..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..46
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   347 AA;  38016 MW;  261C5AD7651947D7 CRC64;
     MFDRLREKLG DFRKSIDEKL KASPQEPVQE KAEAKVEEKI EAPKAEAPAE APRSGILDRA
     KAITRGEVIL SEKDLEGPLW ELEMALLESD VALPVAESII DRIRKDLSGQ HKKFLRSTGD
     IAEDALRDAI LTILSAHTLD FDDYVKGHDK PVIVVFTGVN GTGKTTTIAK LAERLKESNV
     GVVIAAGDTF RAGAIEQLQK HADRLGVKMI KHDQGSDPAA VIYDAVAYAK SNKKDVVLAD
     TAGRLHTNVN LMEQLKKISR IIRPDLVIFV DEAIAGNDAV ERAKLFNDAV PISGSILTKA
     DADSKGGAAI SIAHITGKPI LFLGVGQEYK DLRKFDPDWF VERLLER
//

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