(data stored in ACNUC10043 zone)

SWISSPROT: D1YUY4_METPS

ID   D1YUY4_METPS            Unreviewed;       723 AA.
AC   D1YUY4;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   11-DEC-2019, entry version 51.
DE   SubName: Full=Putative pyruvate carboxylase subunit A {ECO:0000313|EMBL:BAI60256.1};
GN   Name=pycA {ECO:0000313|EMBL:BAI60256.1};
GN   OrderedLocusNames=MCP_0184 {ECO:0000313|EMBL:BAI60256.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI60256.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT   paludicola, the first cultivated representative of the order
RT   Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
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DR   EMBL; AP011532; BAI60256.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_0184; -.
DR   EnsemblBacteria; BAI60256; BAI60256; MCP_0184.
DR   KEGG; mpd:MCP_0184; -.
DR   PATRIC; fig|304371.9.peg.190; -.
DR   eggNOG; arCOG01590; Archaea.
DR   eggNOG; arCOG01940; Archaea.
DR   eggNOG; COG0340; LUCA.
DR   eggNOG; COG0439; LUCA.
DR   HOGENOM; HOG000008988; -.
DR   KO; K01959; -.
DR   OMA; DYDPMLA; -.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006464; P:cellular protein modification process; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd16442; BPL; 1.
DR   HAMAP; MF_00978; Bifunct_BirA; 1.
DR   InterPro; IPR004549; Acetyl_CoA_COase_biotin_COase.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR005481; BC-like_N.
DR   InterPro; IPR030855; Bifunct_BirA.
DR   InterPro; IPR011764; Biotin_carboxylation_dom.
DR   InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR   InterPro; IPR005482; Biotin_COase_C.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   InterPro; IPR008988; Transcriptional_repressor_C.
DR   Pfam; PF02785; Biotin_carb_C; 1.
DR   Pfam; PF00289; Biotin_carb_N; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   Pfam; PF02786; CPSase_L_D2; 1.
DR   SMART; SM00878; Biotin_carb_C; 1.
DR   SUPFAM; SSF50037; SSF50037; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   TIGRFAMs; TIGR00514; accC; 1.
DR   TIGRFAMs; TIGR00121; birA_ligase; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS50979; BC; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
DR   PROSITE; PS00866; CPSASE_1; 1.
DR   PROSITE; PS00867; CPSASE_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1YUY4.
DR   SWISS-2DPAGE; D1YUY4.
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW   Pyruvate {ECO:0000313|EMBL:BAI60256.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001882}.
FT   DOMAIN          1..446
FT                   /note="Biotin carboxylation"
FT                   /evidence="ECO:0000259|PROSITE:PS50979"
FT   DOMAIN          120..317
FT                   /note="ATP-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS50975"
FT   DOMAIN          454..645
FT                   /note="BPL/LPL catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51733"
SQ   SEQUENCE   723 AA;  79618 MW;  83E8E049DA539BCB CRC64;
     MFNKVLIANR GEIALRIERA CKELGISTVA VYSEADAKSL HVKYADEAYS IGPPPVKSSY
     LNVDALLEVA ADSGCDAVHP GYGFLSENAP FAESVRKAGA TFIGPPPSVI KKLGDKTVAR
     STMKKAGLPL IPGSTGTLRS ADEAIELANR FGYPCIIKAA GGGGGRGMRL VFSDAEVPDA
     LESAKREAEA FFSNGDVYIE KYLEDPRHIE FQILADKSGN VIHLGERDCS IQRRHQKLLE
     EAPSPRMTPV LRETMGNAAV QGAKAVKYEN AGTFEFLLDK YGNFYFMEVN TRIQVEHPVT
     ELVTGMDLVK EQLRIAAGEE LPYRQSDIKI NGHAIECRIN AEDPQENFFP SPGKITQYMA
     PGGPGVRIDG CSYPGYEIPP YYDSMVAKLI VWDSNRAGAI NRMRRALDEY VVEGVKTTIP
     FHKMILFNAY FRKGDYSTSF ITKNILNEDK LIPKEIKKGL KTKVLGQKIH YFEEVASTNR
     IAKEMAAAGA AEGTMVLAET QSGGVKGRIG REWISPFGGV CFSLVLRPKC QPRHATKITL
     AAASAVCKTI RDLYGLDAKI NWPNDILIGG RKVCGILTDM AMDVNSIKYI VLGFGVNVNV
     ERLSFPQKIQ KTATSIKEEL GKTVSRKDFI DALLVEFERQ YQNFNDGQYG VILDEYKSLA
     YPLGGHIIVK DQDKLYEGQS VDISEDGALV MKTKEGTVMT FVTGDVHAHP DEVLKKDEVR
     HEA
//

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