(data stored in ACNUC10043 zone)

SWISSPROT: D1YVN5_METPS

ID   D1YVN5_METPS            Unreviewed;       506 AA.
AC   D1YVN5;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   11-DEC-2019, entry version 47.
DE   RecName: Full=Replication factor C large subunit {ECO:0000256|HAMAP-Rule:MF_01508, ECO:0000256|SAAS:SAAS00342041};
DE            Short=RFC large subunit {ECO:0000256|HAMAP-Rule:MF_01508};
DE   AltName: Full=Clamp loader large subunit {ECO:0000256|HAMAP-Rule:MF_01508};
GN   Name=rfcL {ECO:0000256|HAMAP-Rule:MF_01508,
GN   ECO:0000313|EMBL:BAI60507.1};
GN   OrderedLocusNames=MCP_0435 {ECO:0000313|EMBL:BAI60507.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI60507.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT   paludicola, the first cultivated representative of the order
RT   Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
CC   -!- FUNCTION: Part of the RFC clamp loader complex which loads the PCNA
CC       sliding clamp onto DNA. {ECO:0000256|HAMAP-Rule:MF_01508,
CC       ECO:0000256|SAAS:SAAS00342043}.
CC   -!- SUBUNIT: Heteromultimer composed of small subunits (RfcS) and large
CC       subunits (RfcL). {ECO:0000256|HAMAP-Rule:MF_01508}.
CC   -!- SIMILARITY: Belongs to the activator 1 small subunits family. RfcL
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_01508,
CC       ECO:0000256|SAAS:SAAS00538845}.
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DR   EMBL; AP011532; BAI60507.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_0435; -.
DR   EnsemblBacteria; BAI60507; BAI60507; MCP_0435.
DR   KEGG; mpd:MCP_0435; -.
DR   PATRIC; fig|304371.9.peg.447; -.
DR   eggNOG; arCOG00470; Archaea.
DR   eggNOG; COG0470; LUCA.
DR   HOGENOM; HOG000271062; -.
DR   KO; K04800; -.
DR   OMA; GGWTRYG; -.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01508; RfcL; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR023935; Rep_factor-C_lsu.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1YVN5.
DR   SWISS-2DPAGE; D1YVN5.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01508,
KW   ECO:0000256|SAAS:SAAS00420721};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01508,
KW   ECO:0000256|SAAS:SAAS00009872};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01508,
KW   ECO:0000256|SAAS:SAAS00420720};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001882}.
FT   DOMAIN          41..165
FT                   /note="AAA"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   NP_BIND         49..56
FT                   /note="ATP"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01508"
FT   REGION          441..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..471
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        484..506
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  56314 MW;  0573F79CD295FB1E CRC64;
     MSEERCMDWA EKYRPVSLSG VLGNDAAVKA LRKWAETFGS GKKAAILYGG PGIGKTSAAL
     ALAHDMGWDY IEMNASDQRT KDAINKVAGS ASKTGTFGGT NERRLLILDE ADNLHGNYDR
     GGEAAIINVI KNTNQPIILI ANDFYALSKP LRDAAEPIQF RALLSTSIVK ALKKICAAEN
     IKCQPEALMK IAERTNDMRS AINDLQAAAM GREEVTLADV STGERDVPES IFKVMGLIFR
     GDDPGKARRA VMDLDESPED LIGWVDENLP REYHDGDLER GFDALSKADL FLARVRRRMD
     YGMWRYASFM MVAGVNRARK RRYGGYSKYS APTYWQKLGR ARGTRAVRDS LAAKIGKYCH
     TSKREARAVF IPLLRVLFRD EGYAVGITAR LKLEEDEIAF LLDAEKSSKK VGKVYEKSRD
     LIEKEVEHEI DVFARFAPKE PSAHKVEETA AEPAAEPAPK PKRKRKTARD GGEVPAPAIV
     VEPLVEEPKK EEAPSEPKRQ RTLFDF
//

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