(data stored in ACNUC10043 zone)

SWISSPROT: D1YVW2_METPS

ID   D1YVW2_METPS            Unreviewed;       443 AA.
AC   D1YVW2;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   11-DEC-2019, entry version 41.
DE   RecName: Full=Methyl-coenzyme M reductase subunit beta {ECO:0000256|PIRNR:PIRNR000263};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000263};
DE   AltName: Full=Coenzyme-B sulfoethylthiotransferase beta {ECO:0000256|PIRNR:PIRNR000263};
GN   Name=mcrB {ECO:0000313|EMBL:BAI60584.1};
GN   OrderedLocusNames=MCP_0512 {ECO:0000313|EMBL:BAI60584.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI60584.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT   paludicola, the first cultivated representative of the order
RT   Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B
CC         heterodisulfide + methane; Xref=Rhea:RHEA:12532, ChEBI:CHEBI:16183,
CC         ChEBI:CHEBI:58286, ChEBI:CHEBI:58411, ChEBI:CHEBI:58596; EC=2.8.4.1;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000263};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction; methane
CC       from methyl-coenzyme M: step 1/1. {ECO:0000256|PIRNR:PIRNR000263}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000263}.
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DR   EMBL; AP011532; BAI60584.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_0512; -.
DR   EnsemblBacteria; BAI60584; BAI60584; MCP_0512.
DR   KEGG; mpd:MCP_0512; -.
DR   PATRIC; fig|304371.9.peg.527; -.
DR   eggNOG; arCOG04860; Archaea.
DR   eggNOG; COG4054; LUCA.
DR   HOGENOM; HOG000225842; -.
DR   KO; K00401; -.
DR   OMA; TAMFEMG; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR003179; Me_CoM_Rdtase_bsu.
DR   InterPro; IPR022679; Me_CoM_Rdtase_bsu_C.
DR   InterPro; IPR022680; Me_CoM_Rdtase_bsu_N.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02241; MCR_beta; 1.
DR   Pfam; PF02783; MCR_beta_N; 1.
DR   PIRSF; PIRSF000263; Meth_CoM_rd_beta; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03257; met_CoM_red_bet; 1.
PE   4: Predicted;
DR   PRODOM; D1YVW2.
DR   SWISS-2DPAGE; D1YVW2.
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000263};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001882};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000263}.
FT   DOMAIN          6..187
FT                   /note="MCR_beta_N"
FT                   /evidence="ECO:0000259|Pfam:PF02783"
FT   DOMAIN          189..436
FT                   /note="MCR_beta"
FT                   /evidence="ECO:0000259|Pfam:PF02241"
SQ   SEQUENCE   443 AA;  46938 MW;  DC9576E850579FF3 CRC64;
     MPKFKDKIDL YDDKGKLLEK DVPLEAISPV INPAIRKIVN LTKRTVAVSL EGIESALKTG
     KVGGKGRQVL GRSLDLSIVK DADKIAKVVA DTVRINKSDD TAVKVIGGGK SLLVQVPTQR
     VEAGAEFVAS LSCTASAVTE AIIDMYKVDM FDGPFVKNAV WGMYPQTMDL VGGNVKMILE
     IPQKDEGVGY ALRNILTNHC VVIAKRNTMN VAALSSIFEQ AGVCEMGDAV GPWERYQLLG
     FAYQGLNANN LVYSTVKENG KNGTIGSVVA SVIGKAIEDK VIKVEKTLPS GYKLYTTDDI
     PLWNAYTAAA TMAATMVNCG ALRGAQAVSS TLLYTNDLIE RETGLPGCDF GKVEGTAVGF
     SFFSHSIYGG GGPGVFNGNH VVTRHSKGFA VPCVSAACSL DAGTQMFSPE ATSGILGIFG
     EIAEFREPLS HVAKGAAEVK GKV
//

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