(data stored in ACNUC10043 zone)

SWISSPROT: D1YW31_METPS

ID   D1YW31_METPS            Unreviewed;       252 AA.
AC   D1YW31;
DT   09-FEB-2010, integrated into UniProtKB/TrEMBL.
DT   09-FEB-2010, sequence version 1.
DT   11-DEC-2019, entry version 50.
DE   RecName: Full=Non-homologous end joining protein Ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   Name=ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN   OrderedLocusNames=MCP_0581 {ECO:0000313|EMBL:BAI60653.1};
OS   Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 /
OS   SANAE).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=304371 {ECO:0000313|EMBL:BAI60653.1, ECO:0000313|Proteomes:UP000001882};
RN   [1] {ECO:0000313|Proteomes:UP000001882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17711 / JCM 13418 / NBRC 101707 / SANAE
RC   {ECO:0000313|Proteomes:UP000001882};
RX   PubMed=21829548; DOI=10.1371/journal.pone.0022898;
RA   Sakai S., Takaki Y., Shimamura S., Sekine M., Tajima T., Kosugi H.,
RA   Ichikawa N., Tasumi E., Hiraki A.T., Shimizu A., Kato Y., Nishiko R.,
RA   Mori K., Fujita N., Imachi H., Takai K.;
RT   "Genome sequence of a mesophilic hydrogenotrophic methanogen Methanocella
RT   paludicola, the first cultivated representative of the order
RT   Methanocellales.";
RL   PLoS ONE 6:E22898-E22898(2011).
CC   -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC       repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC       linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC       nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC       {ECO:0000256|HAMAP-Rule:MF_01875}.
CC   -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
CC   -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000256|HAMAP-
CC       Rule:MF_01875}.
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DR   EMBL; AP011532; BAI60653.1; -; Genomic_DNA.
DR   STRING; 304371.MCP_0581; -.
DR   EnsemblBacteria; BAI60653; BAI60653; MCP_0581.
DR   KEGG; mpd:MCP_0581; -.
DR   eggNOG; arCOG10146; Archaea.
DR   eggNOG; COG1273; LUCA.
DR   KO; K10979; -.
DR   OMA; IWKGAVS; -.
DR   Proteomes; UP000001882; Chromosome.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.290.10; -; 1.
DR   HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR   InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR   InterPro; IPR009187; Prok_Ku.
DR   InterPro; IPR016194; SPOC-like_C_dom_sf.
DR   PANTHER; PTHR41251; PTHR41251; 1.
DR   Pfam; PF02735; Ku; 1.
DR   PIRSF; PIRSF006493; Prok_Ku; 1.
DR   SMART; SM00559; Ku78; 1.
DR   SUPFAM; SSF100939; SSF100939; 1.
PE   3: Inferred from homology;
DR   PRODOM; D1YW31.
DR   SWISS-2DPAGE; D1YW31.
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA recombination {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_01875};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01875};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001882}.
FT   DOMAIN          52..182
FT                   /note="Ku"
FT                   /evidence="ECO:0000259|SMART:SM00559"
SQ   SEQUENCE   252 AA;  28730 MW;  CB27C378C3125B92 CRC64;
     MQAIWSGNLA FGTILIPVRM YAASEELRVP FHLVHAEDGG RVKYKKVCEL DGKELHMSDI
     HKGYEIGDKM LQFTDEELDE LRPVLSKSLK ILGFCEQEEV PLLALEQPFY LGTESRKKGV
     AQPFALVKKA MEKSGKVAIV SWVTRASEQI GMMMPYEKGF LIKAILYQQQ IRPFDRVEVQ
     ESEVSEDLID KGIMLIERMT FKFDHAAYKE SYSQALREII EAKALGKEVK VEPVVKSAET
     RSLEAELERM LV
//

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