(data stored in SCRATCH zone)

SWISSPROT: D4YX38_SPHJU

ID   D4YX38_SPHJU            Unreviewed;       356 AA.
AC   D4YX38;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   08-MAY-2019, entry version 45.
DE   RecName: Full=Adenine DNA glycosylase {ECO:0000256|RuleBase:RU365096};
DE            EC=3.2.2.31 {ECO:0000256|RuleBase:RU365096};
GN   Name=mutY {ECO:0000313|EMBL:BAI94920.1};
GN   OrderedLocusNames=SJA_C1-00860 {ECO:0000313|EMBL:BAI94920.1};
OS   Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26
OS   / NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662 {ECO:0000313|EMBL:BAI94920.1, ECO:0000313|Proteomes:UP000007753};
RN   [1] {ECO:0000313|EMBL:BAI94920.1, ECO:0000313|Proteomes:UP000007753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S
RC   {ECO:0000313|Proteomes:UP000007753};
RX   PubMed=20817768; DOI=10.1128/JB.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A.,
RA   Fukui S., Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum
RT   UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- FUNCTION: Adenine glycosylase active on G-A mispairs.
CC       {ECO:0000256|RuleBase:RU365096}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolyzes free adenine bases from 7,8-dihydro-8-
CC         oxoguanine:adenine mismatched double-stranded DNA, leaving an
CC         apurinic site.; EC=3.2.2.31;
CC         Evidence={ECO:0000256|RuleBase:RU365096};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU365096};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|RuleBase:RU365096};
CC   -!- SIMILARITY: Belongs to the Nth/MutY family.
CC       {ECO:0000256|RuleBase:RU365096}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AP010803; BAI94920.1; -; Genomic_DNA.
DR   RefSeq; WP_007687378.1; NC_014006.1.
DR   STRING; 452662.SJA_C1-00860; -.
DR   EnsemblBacteria; BAI94920; BAI94920; SJA_C1-00860.
DR   GeneID; 29271799; -.
DR   KEGG; sjp:SJA_C1-00860; -.
DR   eggNOG; ENOG4105CEN; Bacteria.
DR   eggNOG; COG1194; LUCA.
DR   HOGENOM; HOG000028743; -.
DR   KO; K03575; -.
DR   OMA; RDPYRVW; -.
DR   Proteomes; UP000007753; Chromosome 1.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006284; P:base-excision repair; IEA:UniProtKB-UniRule.
DR   CDD; cd03431; DNA_Glycosylase_C; 1.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 1.10.1670.10; -; 1.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR004036; Endonuclease-III-like_CS2.
DR   InterPro; IPR003651; Endonuclease3_FeS-loop_motif.
DR   InterPro; IPR004035; Endouclease-III_FeS-bd_BS.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR000445; HhH_motif.
DR   InterPro; IPR023170; HTH_base_excis_C.
DR   InterPro; IPR029119; MutY_C.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   Pfam; PF10576; EndIII_4Fe-2S; 1.
DR   Pfam; PF00633; HHH; 1.
DR   Pfam; PF00730; HhH-GPD; 1.
DR   Pfam; PF14815; NUDIX_4; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SMART; SM00525; FES; 1.
DR   SUPFAM; SSF48150; SSF48150; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   PROSITE; PS00764; ENDONUCLEASE_III_1; 1.
DR   PROSITE; PS01155; ENDONUCLEASE_III_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D4YX38.
DR   SWISS-2DPAGE; D4YX38.
KW   Complete proteome {ECO:0000313|Proteomes:UP000007753};
KW   DNA damage {ECO:0000256|RuleBase:RU365096};
KW   Glycosidase {ECO:0000256|RuleBase:RU365096,
KW   ECO:0000313|EMBL:BAI94920.1};
KW   Hydrolase {ECO:0000313|EMBL:BAI94920.1};
KW   Iron {ECO:0000256|RuleBase:RU365096};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007753}.
FT   DOMAIN       47    196       ENDO3c. {ECO:0000259|SMART:SM00478}.
SQ   SEQUENCE   356 AA;  38251 MW;  162956DA2CF5A007 CRC64;
     MRVEGPSDKI ASDLLAHYDV HARSLPWRAP PGANAADPYR VWLSEVMLQQ TTVAAVGPYF
     ATFTRRWPDV AALAAEEDAE VMAAWAGLGY YARARNLLAC ARAVAGQHGG AFPDTEEGLR
     ALPGVGAYTA AAVAAIAFGR RAVVVDANVE RVVARLFAIS TPLPAARPEI RAATDAITPD
     LRAGDFAQAM MDLGATICTA RNPACGICPL RPHCAAFRTA DPAAFPVKAA KKAKPRRLGH
     GWWIERQDGH VWLVRRPGRG MLGGMRALPS SEWNDAPDAT PPLPAPWRQV AEPVAHVFTH
     FSLALTVHHA HVGQDATPPG EGEWWPVAEI GRAGLPTLFA RAAEAAMKER RKDARF
//

If you have problems or comments...

PBIL Back to PBIL home page