(data stored in ACNUC7421 zone)

SWISSPROT: D4YXD6_SPHJU

ID   D4YXD6_SPHJU            Unreviewed;       526 AA.
AC   D4YXD6;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   07-JUN-2017, entry version 49.
DE   RecName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|RuleBase:RU363003};
DE            EC=1.1.1.95 {ECO:0000256|RuleBase:RU363003};
GN   Name=serA {ECO:0000313|EMBL:BAI95018.1};
GN   OrderedLocusNames=SJA_C1-01840 {ECO:0000313|EMBL:BAI95018.1};
OS   Sphingobium japonicum (strain NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662 {ECO:0000313|EMBL:BAI95018.1, ECO:0000313|Proteomes:UP000007753};
RN   [1] {ECO:0000313|EMBL:BAI95018.1, ECO:0000313|Proteomes:UP000007753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101211 / UT26S {ECO:0000313|Proteomes:UP000007753};
RX   PubMed=20817768; DOI=10.1128/JB.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A.,
RA   Fukui S., Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum
RT   UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- CATALYTIC ACTIVITY: 3-phospho-D-glycerate + NAD(+) = 3-
CC       phosphonooxypyruvate + NADH. {ECO:0000256|RuleBase:RU363003}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine
CC       from 3-phospho-D-glycerate: step 1/3.
CC       {ECO:0000256|RuleBase:RU363003}.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU363003}.
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DR   EMBL; AP010803; BAI95018.1; -; Genomic_DNA.
DR   RefSeq; WP_007685466.1; NC_014006.1.
DR   ProteinModelPortal; D4YXD6; -.
DR   STRING; 452662.SJA_C1-01840; -.
DR   EnsemblBacteria; BAI95018; BAI95018; SJA_C1-01840.
DR   GeneID; 29271890; -.
DR   KEGG; sjp:SJA_C1-01840; -.
DR   eggNOG; ENOG4108JQ1; Bacteria.
DR   eggNOG; COG0111; LUCA.
DR   HOGENOM; HOG000136693; -.
DR   KO; K00058; -.
DR   OMA; NIAGMQV; -.
DR   OrthoDB; POG091H02MK; -.
DR   UniPathway; UPA00135; UER00196.
DR   Proteomes; UP000007753; Chromosome 1.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004617; F:phosphoglycerate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1330.90; -; 1.
DR   InterPro; IPR029009; ASB_dom.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR006236; PGDH.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   SUPFAM; SSF143548; SSF143548; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01327; PGDH; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
DR   PRODOM; D4YXD6.
DR   SWISS-2DPAGE; D4YXD6.
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU363003};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007753};
KW   NAD {ECO:0000256|RuleBase:RU363003};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU363003,
KW   ECO:0000313|EMBL:BAI95018.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007753};
KW   Serine biosynthesis {ECO:0000256|RuleBase:RU363003}.
FT   DOMAIN        4    312       2-Hacid_dh. {ECO:0000259|Pfam:PF00389}.
FT   DOMAIN      106    280       2-Hacid_dh_C. {ECO:0000259|Pfam:PF02826}.
SQ   SEQUENCE   526 AA;  55822 MW;  0051209535C2E0E0 CRC64;
     MPKVLISDKM DPRAAAIFRE RGVEVDEITG KTPEELKAII GQYDGLAIRS STKVTKDILD
     HATNLKVIGR AGIGVDNVDI PAASAKGVIV MNTPFGNSIT TAEHAIALMF ALARQLPEAN
     AQTQQGLWPK NGFMGVEVTG KTLGLIGAGN IGSIVASRAL GLKMKVVAFD PFLTPERAVE
     MGVEKADLDT LLAKADFITL HTPLTDQTRN ILSKENLAKT KKGVRIINCA RGGLIDEAAL
     KEALDSGHVA GAALDVFVQE PAKESPLFGT PNFICTPHLG ASTDEAQVNV ALQVAEQLSD
     YLLDGGITNA LNVPSLSAEE APKLKPYMAL AEELGSLVGQ LEGDRIQSVS VEVEGHAAEL
     NQKPITAAVL AGLMRVYSDT VNMVNAPFLA KERGLDVREV RHDREGDYQT LVRVTVKTES
     GDKSVAGTLF GNAQPRLVEL FGIKVEADLA GDMLYIVNQD APGFIGRLGS TLGEAQVNIG
     TFHLGRRNQG GEAVLLLSLD GAVNEAVLSD ICKLAGVKTV KLLRFA
//

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