(data stored in ACNUC7421 zone)

SWISSPROT: D4YXK1_SPHJU

ID   D4YXK1_SPHJU            Unreviewed;       309 AA.
AC   D4YXK1;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   07-JUN-2017, entry version 46.
DE   RecName: Full=Protease HtpX homolog {ECO:0000256|HAMAP-Rule:MF_00188};
DE            EC=3.4.24.- {ECO:0000256|HAMAP-Rule:MF_00188};
GN   Name=htpX {ECO:0000256|HAMAP-Rule:MF_00188,
GN   ECO:0000313|EMBL:BAI95083.1};
GN   OrderedLocusNames=SJA_C1-02490 {ECO:0000313|EMBL:BAI95083.1};
OS   Sphingobium japonicum (strain NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662 {ECO:0000313|EMBL:BAI95083.1, ECO:0000313|Proteomes:UP000007753};
RN   [1] {ECO:0000313|EMBL:BAI95083.1, ECO:0000313|Proteomes:UP000007753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101211 / UT26S {ECO:0000313|Proteomes:UP000007753};
RX   PubMed=20817768; DOI=10.1128/JB.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A.,
RA   Fukui S., Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum
RT   UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00188, ECO:0000256|RuleBase:RU003983};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
CC       Rule:MF_00188, ECO:0000256|RuleBase:RU003983};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_00188}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_00188}.
CC   -!- SIMILARITY: Belongs to the peptidase M48B family.
CC       {ECO:0000256|HAMAP-Rule:MF_00188, ECO:0000256|RuleBase:RU003983,
CC       ECO:0000256|SAAS:SAAS00541274}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00188}.
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DR   EMBL; AP010803; BAI95083.1; -; Genomic_DNA.
DR   STRING; 452662.SJA_C1-02490; -.
DR   MEROPS; M48.004; -.
DR   EnsemblBacteria; BAI95083; BAI95083; SJA_C1-02490.
DR   KEGG; sjp:SJA_C1-02490; -.
DR   eggNOG; ENOG4105D0M; Bacteria.
DR   eggNOG; COG0501; LUCA.
DR   HOGENOM; HOG000227301; -.
DR   KO; K03799; -.
DR   OMA; REYMADS; -.
DR   OrthoDB; POG091H01BW; -.
DR   Proteomes; UP000007753; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_00188; Pept_M48_protease_HtpX; 1.
DR   InterPro; IPR022919; Pept_M48_protease_HtpX.
DR   InterPro; IPR001915; Peptidase_M48.
DR   Pfam; PF01435; Peptidase_M48; 1.
PE   3: Inferred from homology;
DR   PRODOM; D4YXK1.
DR   SWISS-2DPAGE; D4YXK1.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00188};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00188,
KW   ECO:0000256|SAAS:SAAS00016474};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007753};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00188,
KW   ECO:0000256|RuleBase:RU003983, ECO:0000256|SAAS:SAAS00112036};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00188,
KW   ECO:0000256|SAAS:SAAS00016464};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00188,
KW   ECO:0000256|SAAS:SAAS00112149};
KW   Metalloprotease {ECO:0000256|HAMAP-Rule:MF_00188,
KW   ECO:0000256|RuleBase:RU003983, ECO:0000256|SAAS:SAAS00473668};
KW   Protease {ECO:0000256|HAMAP-Rule:MF_00188,
KW   ECO:0000256|RuleBase:RU003983, ECO:0000256|SAAS:SAAS00112256};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007753};
KW   Stress response {ECO:0000313|EMBL:BAI95083.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_00188,
KW   ECO:0000256|SAAS:SAAS00016455};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00188,
KW   ECO:0000256|SAAS:SAAS00016434};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00188, ECO:0000256|RuleBase:RU003983,
KW   ECO:0000256|SAAS:SAAS00112070}.
FT   TRANSMEM    141    163       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00188}.
FT   TRANSMEM    175    196       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00188}.
FT   DOMAIN       67    273       Peptidase_M48. {ECO:0000259|Pfam:
FT                                PF01435}.
FT   ACT_SITE    131    131       {ECO:0000256|HAMAP-Rule:MF_00188}.
FT   METAL       130    130       Zinc; catalytic. {ECO:0000256|HAMAP-Rule:
FT                                MF_00188}.
FT   METAL       134    134       Zinc; catalytic. {ECO:0000256|HAMAP-Rule:
FT                                MF_00188}.
FT   METAL       201    201       Zinc; catalytic. {ECO:0000256|HAMAP-Rule:
FT                                MF_00188}.
SQ   SEQUENCE   309 AA;  32360 MW;  F502059EFC454A46 CRC64;
     MNGMKTAMLL SALTALFMAL GYTLGGSGGA AIALLVAAGM NLFTFWNADR IVLSMHNARE
     VDAQSAPEFY TLVAELARRA GLPMPRVYLI DQPHPNAFAT GRDPDHAAVA ATTGLLSMLS
     RDEVAGVMAH ELGHVRNRDT LIMTMVATIA GAISMLANFG LFFRGGNQEN GHGNIAATLL
     AVIVAPFAAM IVQMAISRTR EYGADRAGAE ISGNPRALAS ALAKISGRAE TIPNPVAERN
     PAAAQLYIVP VHVSELFSTH PATEKRIAAL EEMAGGAPLP RRASALSPAA SSAAPKGRKS
     SALDPLRRD
//

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