(data stored in ACNUC7421 zone)

SWISSPROT: D4YXY4_SPHJU

ID   D4YXY4_SPHJU            Unreviewed;       689 AA.
AC   D4YXY4;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   08-MAY-2019, entry version 54.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:BAI95216.1};
DE            EC=1.1.1.35 {ECO:0000313|EMBL:BAI95216.1};
GN   Name=fadB {ECO:0000313|EMBL:BAI95216.1};
GN   OrderedLocusNames=SJA_C1-03820 {ECO:0000313|EMBL:BAI95216.1};
OS   Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26
OS   / NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662 {ECO:0000313|EMBL:BAI95216.1, ECO:0000313|Proteomes:UP000007753};
RN   [1] {ECO:0000313|EMBL:BAI95216.1, ECO:0000313|Proteomes:UP000007753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S
RC   {ECO:0000313|Proteomes:UP000007753};
RX   PubMed=20817768; DOI=10.1128/JB.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A.,
RA   Fukui S., Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum
RT   UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000256|RuleBase:RU003707}.
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DR   EMBL; AP010803; BAI95216.1; -; Genomic_DNA.
DR   RefSeq; WP_013038999.1; NC_014006.1.
DR   STRING; 452662.SJA_C1-03820; -.
DR   EnsemblBacteria; BAI95216; BAI95216; SJA_C1-03820.
DR   GeneID; 29272070; -.
DR   KEGG; sjp:SJA_C1-03820; -.
DR   eggNOG; ENOG4105DYT; Bacteria.
DR   eggNOG; COG1250; LUCA.
DR   HOGENOM; HOG000261347; -.
DR   KO; K07516; -.
DR   OMA; IDLCMIL; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000007753; Chromosome 1.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; D4YXY4.
DR   SWISS-2DPAGE; D4YXY4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000007753};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00331296,
KW   ECO:0000313|EMBL:BAI95216.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007753}.
FT   DOMAIN      300    474       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      480    562       3HCDH. {ECO:0000259|Pfam:PF00725}.
FT   DOMAIN      600    683       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   689 AA;  72751 MW;  F4A6D9D2B83BEDCC CRC64;
     MKQTATSVVV DGVALITLDN PPVNALSASL RQGLQAELEQ AFGDEEVGAI LLLCAGRTFI
     AGADITEFGQ PWQPPSLPDL CAMLDGAPKP VIAAIHGTAL GGGFELALAC HYRVAARSAK
     VGLPEVHLGL LPGAGGTQRV PRIVGAEAAL DIITSGRQIK AAEALSLGLV DAVVDDAALA
     EEALAFARRV VADGGAKPRI RDRADAIEGD RNRPELFTAF AAANARRFKG FVAPAAIIGA
     VEAAVTLPFD EGLAKETALF ERLVASPESA AQRHVFFAER EAARVPDIGP DISAIDIRSV
     GVIGAGTMGG GITMNFLNAG IPITLVETTQ EALDRGIATI RRNYETTAAK GRMTAAQVEQ
     RMGLISPSLD LAALADADLI IEAVYESMDV KTDIFARLDR IAKLGAILAS NTSFLDLNRI
     AAATSRPEWV VGLHFFSPAN VMRLLEVVRG AATSKPVVAT AMRLAKRIGK VAVLSGVCDG
     FIANRLLAPR GAQAEAMMLE GTPIAEIDRV LVDYGFAMGH FQMMDLVGLD VIGRNATERT
     VMGDLVAAGR LGQKRGAGYY DYDEKRRSRP SDVTGSLIKE VAAARGVAHA PTSGDEALLA
     RLLYPVVNEG AKILEEGIAL RASDIDIAAV LGYNWPVYRG GPLFWADQVG LDRIVAEMRR
     LEAVHGETFR PAPLLVRLAE AGRRFGDGS
//

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