(data stored in ACNUC7421 zone)

SWISSPROT: D4YY15_SPHJU

ID   D4YY15_SPHJU            Unreviewed;      1090 AA.
AC   D4YY15;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   05-JUL-2017, entry version 51.
DE   RecName: Full=Error-prone DNA polymerase {ECO:0000256|HAMAP-Rule:MF_01902};
DE            EC=2.7.7.7 {ECO:0000256|HAMAP-Rule:MF_01902};
GN   Name=dnaE {ECO:0000313|EMBL:BAI95247.1};
GN   Synonyms=dnaE2 {ECO:0000256|HAMAP-Rule:MF_01902};
GN   OrderedLocusNames=SJA_C1-04130 {ECO:0000313|EMBL:BAI95247.1};
OS   Sphingobium japonicum (strain NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662 {ECO:0000313|EMBL:BAI95247.1, ECO:0000313|Proteomes:UP000007753};
RN   [1] {ECO:0000313|EMBL:BAI95247.1, ECO:0000313|Proteomes:UP000007753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101211 / UT26S {ECO:0000313|Proteomes:UP000007753};
RX   PubMed=20817768; DOI=10.1128/JB.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A.,
RA   Fukui S., Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum
RT   UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- FUNCTION: DNA polymerase involved in damage-induced mutagenesis
CC       and translesion synthesis (TLS). It is not the major replicative
CC       DNA polymerase. {ECO:0000256|HAMAP-Rule:MF_01902}.
CC   -!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
CC       diphosphate + DNA(n+1). {ECO:0000256|HAMAP-Rule:MF_01902,
CC       ECO:0000256|SAAS:SAAS00367602}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01902,
CC       ECO:0000256|SAAS:SAAS00002413}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_01902,
CC       ECO:0000256|SAAS:SAAS00692462}.
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DR   EMBL; AP010803; BAI95247.1; -; Genomic_DNA.
DR   RefSeq; WP_013039027.1; NC_014006.1.
DR   ProteinModelPortal; D4YY15; -.
DR   STRING; 452662.SJA_C1-04130; -.
DR   EnsemblBacteria; BAI95247; BAI95247; SJA_C1-04130.
DR   GeneID; 29272099; -.
DR   KEGG; sjp:SJA_C1-04130; -.
DR   eggNOG; ENOG4105C0B; Bacteria.
DR   eggNOG; COG0587; LUCA.
DR   HOGENOM; HOG000021783; -.
DR   KO; K14162; -.
DR   OMA; NSWPMGF; -.
DR   OrthoDB; POG091H02F7; -.
DR   Proteomes; UP000007753; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   HAMAP; MF_01902; DNApol_error_prone; 1.
DR   InterPro; IPR011708; DNA_pol3_alpha.
DR   InterPro; IPR023073; DNA_pol_error_prone.
DR   InterPro; IPR029460; DNAPol_HHH.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR004013; PHP_dom.
DR   InterPro; IPR003141; Pol/His_phosphatase_N.
DR   InterPro; IPR016195; Pol/histidinol_Pase-like.
DR   InterPro; IPR004805; PolC_alpha.
DR   PANTHER; PTHR32294; PTHR32294; 1.
DR   PANTHER; PTHR32294:SF6; PTHR32294:SF6; 1.
DR   Pfam; PF07733; DNA_pol3_alpha; 1.
DR   Pfam; PF14579; HHH_6; 1.
DR   Pfam; PF02811; PHP; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   SMART; SM00481; POLIIIAc; 1.
DR   SUPFAM; SSF89550; SSF89550; 1.
DR   TIGRFAMs; TIGR00594; polc; 1.
PE   3: Inferred from homology;
DR   PRODOM; D4YY15.
DR   SWISS-2DPAGE; D4YY15.
KW   Complete proteome {ECO:0000313|Proteomes:UP000007753};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01902,
KW   ECO:0000256|SAAS:SAAS00002520};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_01902,
KW   ECO:0000256|SAAS:SAAS00692481};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_01902,
KW   ECO:0000256|SAAS:SAAS00692483};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01902,
KW   ECO:0000256|SAAS:SAAS00444682};
KW   DNA-directed DNA polymerase {ECO:0000256|HAMAP-Rule:MF_01902,
KW   ECO:0000256|SAAS:SAAS00057114};
KW   Nucleotidyltransferase {ECO:0000256|HAMAP-Rule:MF_01902,
KW   ECO:0000256|SAAS:SAAS00057123, ECO:0000313|EMBL:BAI95247.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007753};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_01902,
KW   ECO:0000256|SAAS:SAAS00057121, ECO:0000313|EMBL:BAI95247.1}.
FT   DOMAIN        7     74       POLIIIAc. {ECO:0000259|SMART:SM00481}.
SQ   SEQUENCE   1090 AA;  121501 MW;  D05103C8011996EB CRC64;
     MTAPRYAELQ VTSHFSFLRG ASSCEELFSQ AALAGIEALA VVDRNSLAGI VRAHQAAKTT
     GVRLIVGCRL DLVDGASMLV YPTDRSAYSR LCRLLSLGKQ RAGKAKCHLE WPDLMAYGEG
     LIVVLVPDQA DAECALRLRR LRDAFGDRAY LALTLRRRPN DQLRIHELSN LATQMRVPTV
     VTNDVLFHEP ARRVLQDVVT CIRHNVTIDA LGDRRERHAD RYIKPPEEMH RLFARYPEAL
     ARTLQIADRC RFNLDELAYQ YPEERDDPAL TPQETLAKLT WEGAAQRYPE GVPDSVIAAL
     RHELRLIEKL GYAPYFLTVN AIVRFARSKD ILCQGRGSAA NSAVCYVLGI TSIDPGRNDL
     LFERFVSEER REPPDIDVDF EHERREIVMQ WVFDTYGRDH AALCSTVIRY RTKGALRDVG
     KALGLPEDLI GTLSSQVWAW SEEGVEQRHV EALNLNLADR RLRLTLDLAR QLMGAPRHLS
     QHPGGFVLTH DRLDDLVPIE PAAMKDRQVI EWDKDDIDAL KFMKVDVLAL GMLTCMKKGL
     DLLAEHKGVN LDLASIPAED PRTYAMIRKA DTLGTFQIES RAQMSMLPRL KPRTYYDLVV
     QVAIVRPGPI QGDMVHPYLR RREGLEPVHY PKPELEKVLG KTLGVPLFQE QAMRVAIECA
     GFTPGEADML RKSMATFKFT GGVSHFRDKL IAGMVANGYE QAFAEQTFKQ LEGFGSYGFP
     ESHAASFALI AYASAWLKCW HPDVFCAALL NSQPMGFYAP AQIVRDAIEH GVDVRPVCAN
     ASRWDCTLEP TSDESRYAVR LGLRMVKGLA NTHGAAIVSA RADQPYTSID DLWRRAGAPS
     AALVQLAEAD AFRPALGLAR REALWAIKAL RDEPLPLFAA ASAREAGAIP EIDEPAVALR
     PMTAGGEVVE DYGHVGLTLR THPLSFLRED LQRRRIVTCA EAMAARDGRW VEAAGIVLVR
     QRPGSAKGVM FITLEDETGI ANLVVWTKVF EANRRAILSA SMIAVRGRVQ REGEVVHLVA
     QRITDLSGEL ASVGDRDMAF PLSHGRGDQV RHGGSGPDPR ELPPKGLRTR DIYIPDLHID
     TIKVKTRDFR
//

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