(data stored in SCRATCH zone)

SWISSPROT: D4YY80_SPHJU

ID   D4YY80_SPHJU            Unreviewed;       512 AA.
AC   D4YY80;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   08-MAY-2019, entry version 47.
DE   RecName: Full=Putative thymidine phosphorylase {ECO:0000256|HAMAP-Rule:MF_00703};
DE            EC=2.4.2.4 {ECO:0000256|HAMAP-Rule:MF_00703};
DE   AltName: Full=TdRPase {ECO:0000256|HAMAP-Rule:MF_00703};
GN   OrderedLocusNames=SJA_C1-04780 {ECO:0000313|EMBL:BAI95312.1};
OS   Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26
OS   / NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662 {ECO:0000313|EMBL:BAI95312.1, ECO:0000313|Proteomes:UP000007753};
RN   [1] {ECO:0000313|EMBL:BAI95312.1, ECO:0000313|Proteomes:UP000007753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S
RC   {ECO:0000313|Proteomes:UP000007753};
RX   PubMed=20817768; DOI=10.1128/JB.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A.,
RA   Fukui S., Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum
RT   UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-
CC         phosphate + thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:17821, ChEBI:CHEBI:43474, ChEBI:CHEBI:57259;
CC         EC=2.4.2.4; Evidence={ECO:0000256|HAMAP-Rule:MF_00703};
CC   -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC       phosphorylase family. Type 2 subfamily. {ECO:0000256|HAMAP-
CC       Rule:MF_00703}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AP010803; BAI95312.1; -; Genomic_DNA.
DR   RefSeq; WP_004212749.1; NC_014006.1.
DR   STRING; 452662.SJA_C1-04780; -.
DR   EnsemblBacteria; BAI95312; BAI95312; SJA_C1-04780.
DR   GeneID; 31535592; -.
DR   KEGG; sjp:SJA_C1-04780; -.
DR   eggNOG; ENOG4105CMW; Bacteria.
DR   eggNOG; COG0213; LUCA.
DR   HOGENOM; HOG000252767; -.
DR   KO; K00758; -.
DR   OMA; IYMHPDC; -.
DR   BioCyc; SJAP452662:GHEL-489-MONOMER; -.
DR   Proteomes; UP000007753; Chromosome 1.
DR   GO; GO:0004645; F:phosphorylase activity; IEA:InterPro.
DR   GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1030.10; -; 1.
DR   Gene3D; 3.90.1170.30; -; 1.
DR   HAMAP; MF_00703; Thymid_phosp_2; 1.
DR   InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR   InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR   InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom)sf.
DR   InterPro; IPR035902; Nuc_phospho_transferase.
DR   InterPro; IPR036566; PYNP-like_C_sf.
DR   InterPro; IPR013102; PYNP_C.
DR   InterPro; IPR017872; Pyrmidine_PPase_CS.
DR   InterPro; IPR028579; Thym_Pase_Put.
DR   InterPro; IPR013466; Thymidine/AMP_Pase.
DR   InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR   PANTHER; PTHR10515; PTHR10515; 1.
DR   Pfam; PF02885; Glycos_trans_3N; 1.
DR   Pfam; PF00591; Glycos_transf_3; 1.
DR   Pfam; PF07831; PYNP_C; 1.
DR   PIRSF; PIRSF000478; TP_PyNP; 1.
DR   SMART; SM00941; PYNP_C; 1.
DR   SUPFAM; SSF47648; SSF47648; 1.
DR   SUPFAM; SSF52418; SSF52418; 1.
DR   SUPFAM; SSF54680; SSF54680; 1.
DR   TIGRFAMs; TIGR02645; ARCH_P_rylase; 1.
DR   PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; D4YY80.
DR   SWISS-2DPAGE; D4YY80.
KW   Complete proteome {ECO:0000313|Proteomes:UP000007753};
KW   Glycosyltransferase {ECO:0000256|HAMAP-Rule:MF_00703,
KW   ECO:0000313|EMBL:BAI95312.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007753};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00703,
KW   ECO:0000313|EMBL:BAI95312.1}.
FT   DOMAIN      440    507       PYNP_C. {ECO:0000259|SMART:SM00941}.
SQ   SEQUENCE   512 AA;  52982 MW;  704A9D1ED7BF16D6 CRC64;
     MKPGIIEDAE VEPVATTLRA HRLGLSAAGG DLIAVMRQDC PVCRSEGLAS RAQVALHAGG
     REIVVSLLHS SAEAPAPGEI GLSESAWRRL GVSEGDPVEI AHAQPLASLA EVRRRIYGNR
     LSEGAFSAIM TDIAERRYSD VHLSAFITAC SAVPLDTDET ISLTRAMVDV GERLQWSGAV
     IVDKHSVGGL PGNRTTPIIV SIMAAEGLIM PKTSSRAITS PAGTADTMEV LAPVDLDVSA
     IRKVVEREGG CIAWGGAVNL SPADDVIIGV ERVLDIDAVG QMVASVLSKK IAAGATHLVI
     DIPVGPTAKV RGTDAADTLE RALSSVAQAF GLRTRVMRGP GAEPIGRGIG PALEAQDILA
     VLQGQPGAED LAHRACELAG GLLELADAAP AGEGYARARA CLESGGAWAK FQRICEAQGG
     MRAPPVARFQ QDMIAPYSGR LVSIDNRKLA TVAKLAGAPV AKAAGVALQC RLNQMVDAGA
     PLCSIHAESP GELDYAAAYA VSDGPIFGIE AL
//

If you have problems or comments...

PBIL Back to PBIL home page