(data stored in ACNUC7421 zone)

SWISSPROT: D4YYH0_SPHJU

ID   D4YYH0_SPHJU            Unreviewed;       250 AA.
AC   D4YYH0;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   16-JAN-2019, entry version 44.
DE   RecName: Full=Probable acetoacetate decarboxylase {ECO:0000256|HAMAP-Rule:MF_00597};
DE            Short=AAD {ECO:0000256|HAMAP-Rule:MF_00597};
DE            Short=ADC {ECO:0000256|HAMAP-Rule:MF_00597};
DE            EC=4.1.1.4 {ECO:0000256|HAMAP-Rule:MF_00597};
GN   Name=adc {ECO:0000256|HAMAP-Rule:MF_00597,
GN   ECO:0000313|EMBL:BAI95402.1};
GN   OrderedLocusNames=SJA_C1-05680 {ECO:0000313|EMBL:BAI95402.1};
OS   Sphingobium japonicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26
OS   / NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662 {ECO:0000313|EMBL:BAI95402.1, ECO:0000313|Proteomes:UP000007753};
RN   [1] {ECO:0000313|EMBL:BAI95402.1, ECO:0000313|Proteomes:UP000007753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S
RC   {ECO:0000313|Proteomes:UP000007753};
RX   PubMed=20817768; DOI=10.1128/JB.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A.,
RA   Fukui S., Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum
RT   UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- FUNCTION: Catalyzes the conversion of acetoacetate to acetone and
CC       carbon dioxide. {ECO:0000256|HAMAP-Rule:MF_00597}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetoacetate + H(+) = acetone + CO2;
CC         Xref=Rhea:RHEA:19729, ChEBI:CHEBI:13705, ChEBI:CHEBI:15347,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526; EC=4.1.1.4;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00597};
CC   -!- SIMILARITY: Belongs to the ADC family. {ECO:0000256|HAMAP-
CC       Rule:MF_00597}.
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DR   EMBL; AP010803; BAI95402.1; -; Genomic_DNA.
DR   RefSeq; WP_013039126.1; NC_014006.1.
DR   STRING; 452662.SJA_C1-05680; -.
DR   EnsemblBacteria; BAI95402; BAI95402; SJA_C1-05680.
DR   GeneID; 29272246; -.
DR   KEGG; sjp:SJA_C1-05680; -.
DR   eggNOG; ENOG4107GD3; Bacteria.
DR   eggNOG; COG4689; LUCA.
DR   HOGENOM; HOG000063822; -.
DR   KO; K01574; -.
DR   OMA; CTPRICE; -.
DR   Proteomes; UP000007753; Chromosome 1.
DR   GO; GO:0047602; F:acetoacetate decarboxylase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.400.10; -; 1.
DR   HAMAP; MF_00597; ADC; 1.
DR   InterPro; IPR010451; Acetoacetate_decarboxylase.
DR   InterPro; IPR023653; Acetoacetate_decarboxylase_bac.
DR   InterPro; IPR023375; ADC_dom_sf.
DR   Pfam; PF06314; ADC; 1.
DR   SUPFAM; SSF160104; SSF160104; 1.
PE   3: Inferred from homology;
DR   PRODOM; D4YYH0.
DR   SWISS-2DPAGE; D4YYH0.
KW   Complete proteome {ECO:0000313|Proteomes:UP000007753};
KW   Decarboxylase {ECO:0000256|HAMAP-Rule:MF_00597};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00597, ECO:0000313|EMBL:BAI95402.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007753};
KW   Schiff base {ECO:0000256|HAMAP-Rule:MF_00597}.
FT   ACT_SITE    116    116       Schiff-base intermediate with
FT                                acetoacetate. {ECO:0000256|HAMAP-Rule:
FT                                MF_00597}.
SQ   SEQUENCE   250 AA;  27999 MW;  758275F4209A1644 CRC64;
     MDFDEVRSRA FAMPVCNPAF PRPPYRFYNR EYIVIKYRTD PEALREVVPA PLEIDEPVVN
     YEFIRMPDST GFGDYTETGQ VIPVRFNGVP GGYVHSMYLD DDAPIAGGRE IWGFPKKLAT
     PSIAHESDVI VGKLHYGSAL CALGTMGYKH VILDHEPILA AMRQPNFMLK VIPHVDCTPR
     ICELVRYHLE DIDLKGAWGG PAALDLYPHA LADVARLPVR EIVAATHFIA DLTLGLGEVV
     HDYLKDDPRV
//

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