(data stored in ACNUC7421 zone)

SWISSPROT: D4YYS3_SPHJU

ID   D4YYS3_SPHJU            Unreviewed;       306 AA.
AC   D4YYS3;
DT   15-JUN-2010, integrated into UniProtKB/TrEMBL.
DT   15-JUN-2010, sequence version 1.
DT   07-JUN-2017, entry version 48.
DE   RecName: Full=Protoheme IX farnesyltransferase {ECO:0000256|HAMAP-Rule:MF_00154};
DE            EC=2.5.1.- {ECO:0000256|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme B farnesyltransferase {ECO:0000256|HAMAP-Rule:MF_00154};
DE   AltName: Full=Heme O synthase {ECO:0000256|HAMAP-Rule:MF_00154};
GN   Name=cyoE {ECO:0000313|EMBL:BAI95505.1};
GN   Synonyms=ctaB {ECO:0000256|HAMAP-Rule:MF_00154};
GN   OrderedLocusNames=SJA_C1-06710 {ECO:0000313|EMBL:BAI95505.1};
OS   Sphingobium japonicum (strain NBRC 101211 / UT26S).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingobium.
OX   NCBI_TaxID=452662 {ECO:0000313|EMBL:BAI95505.1, ECO:0000313|Proteomes:UP000007753};
RN   [1] {ECO:0000313|EMBL:BAI95505.1, ECO:0000313|Proteomes:UP000007753}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 101211 / UT26S {ECO:0000313|Proteomes:UP000007753};
RX   PubMed=20817768; DOI=10.1128/JB.00961-10;
RA   Nagata Y., Ohtsubo Y., Endo R., Ichikawa N., Ankai A., Oguchi A.,
RA   Fukui S., Fujita N., Tsuda M.;
RT   "Complete genome sequence of the representative gamma-
RT   hexachlorocyclohexane-degrading bacterium Sphingobium japonicum
RT   UT26.";
RL   J. Bacteriol. 192:5852-5853(2010).
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group. {ECO:0000256|HAMAP-
CC       Rule:MF_00154, ECO:0000256|SAAS:SAAS00719754}.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; heme O
CC       biosynthesis; heme O from protoheme: step 1/1. {ECO:0000256|HAMAP-
CC       Rule:MF_00154, ECO:0000256|SAAS:SAAS00719659}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_00154}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_00154}.
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature. {ECO:0000256|HAMAP-
CC       Rule:MF_00154}.
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       Protoheme IX farnesyltransferase subfamily. {ECO:0000256|HAMAP-
CC       Rule:MF_00154, ECO:0000256|SAAS:SAAS00719682}.
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DR   EMBL; AP010803; BAI95505.1; -; Genomic_DNA.
DR   RefSeq; WP_013039198.1; NC_014006.1.
DR   STRING; 452662.SJA_C1-06710; -.
DR   EnsemblBacteria; BAI95505; BAI95505; SJA_C1-06710.
DR   GeneID; 29272344; -.
DR   KEGG; sjp:SJA_C1-06710; -.
DR   eggNOG; ENOG4105F1R; Bacteria.
DR   eggNOG; COG0109; LUCA.
DR   HOGENOM; HOG000237291; -.
DR   KO; K02301; -.
DR   OMA; WQFPHFW; -.
DR   OrthoDB; POG091H05F2; -.
DR   UniPathway; UPA00834; UER00712.
DR   Proteomes; UP000007753; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:UniProtKB-HAMAP.
DR   CDD; cd13957; PT_UbiA_Cox10; 1.
DR   HAMAP; MF_00154; CyoE_CtaB; 1.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   InterPro; IPR030470; UbiA_prenylTrfase_CS.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; cyoE_ctaB; 1.
DR   PROSITE; PS00943; UBIA; 1.
PE   3: Inferred from homology;
DR   PRODOM; D4YYS3.
DR   SWISS-2DPAGE; D4YYS3.
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00154};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_00154,
KW   ECO:0000256|SAAS:SAAS00078075};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007753};
KW   Heme biosynthesis {ECO:0000256|HAMAP-Rule:MF_00154,
KW   ECO:0000256|SAAS:SAAS00763294};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_00154,
KW   ECO:0000256|SAAS:SAAS00415574};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007753};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00154,
KW   ECO:0000256|SAAS:SAAS00415579, ECO:0000313|EMBL:BAI95505.1};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_00154,
KW   ECO:0000256|SAAS:SAAS00415577};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00154,
KW   ECO:0000256|SAAS:SAAS00415562}.
FT   TRANSMEM     30     49       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00154}.
FT   TRANSMEM     55     75       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00154}.
FT   TRANSMEM     96    116       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00154}.
FT   TRANSMEM    122    142       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00154}.
FT   TRANSMEM    163    186       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00154}.
FT   TRANSMEM    224    241       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00154}.
FT   TRANSMEM    247    267       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00154}.
FT   TRANSMEM    288    305       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_00154}.
SQ   SEQUENCE   306 AA;  33196 MW;  0A87F7AA2BCD552F CRC64;
     MASSPFMSEG PLPVIPAHWR DFVALTKPRV MTLVVFTGLC GLLAAPGHIH PVLAFTAILC
     IALGAGAAAA LNQWYEADID AKMKRTANRP LPAGRMDRQS ALHFGVGLSF FSVLLMGVAT
     NWLAAAVLAV SILFYVFVYT IWLKPRTAQN IVIGGAAGAF PPVIGWAAVT GDIGALPVAL
     FMLIFFWTPP HFWALALFVK TDYAAAGIPM LPVVSGEVAT RRQIWFYTAI MAVAAMAPVL
     LRLTGPIYGT TALLGTALFV AMAFQVLRRR ESDPAHMAPE RRLFKYSILY LFLLFGAVVV
     DRWVFA
//

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