(data stored in ACNUC8465 zone)

EMBL: BK006939

ID   BK006939; SV 2; linear; genomic DNA; STD; FUN; 576874 BP.
XX
AC   BK006939;
XX
PR   Project:PRJNA43747;
XX
DT   05-FEB-2010 (Rel. 103, Created)
DT   01-NOV-2019 (Rel. 142, Last updated, Version 25)
XX
DE   TPA: Saccharomyces cerevisiae S288C chromosome V, complete sequence.
XX
KW   Third Party Data; TPA; TPA:inferential.
XX
OS   Saccharomyces cerevisiae S288C
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
XX
RN   [1]
RP   1-576874
RX   DOI; 10.1126/science.274.5287.546.
RX   PUBMED; 8849441.
RA   Goffeau A., Barrell B.G., Bussey H., Davis R.W., Dujon B., Feldmann H.,
RA   Galibert F., Hoheisel J.D., Jacq C., Johnston M., Louis E.J., Mewes H.W.,
RA   Murakami Y., Philippsen P., Tettelin H., Oliver S.G.;
RT   "Life with 6000 genes";
RL   Science, e1252229 274(5287):546-546(1996).
XX
RN   [2]
RP   1-576874
RX   PUBMED; 9169868.
RA   Dietrich F.S., Mulligan J., Hennessy K., Yelton M.A., Allen E., Araujo R.,
RA   Aviles E., Berno A., Brennan T., Carpenter J., Chen E., Cherry J.M.,
RA   Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S., Hyman R.W.,
RA   Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Davis R.W.et.al.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V";
RL   Nature 387(6632 Suppl):78-81(1997).
XX
RN   [3]
RP   1-576874
RG   Saccharomyces Genome Database
RA   ;
RT   ;
RL   Submitted (11-DEC-2009) to the INSDC.
RL   Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
XX
RN   [4]
RC   Sequence update by submitter
RP   1-576874
RG   Saccharomyces Genome Database
RA   ;
RT   ;
RL   Submitted (31-MAR-2011) to the INSDC.
RL   Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
XX
RN   [5]
RC   Protein update by submitter
RP   1-576874
RG   Saccharomyces Genome Database
RA   ;
RT   ;
RL   Submitted (04-MAY-2012) to the INSDC.
RL   Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
XX
RN   [6]
RC   Protein update by submitter
RP   1-576874
RG   Saccharomyces Genome Database
RA   ;
RT   ;
RL   Submitted (29-JUL-2014) to the INSDC.
RL   Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
XX
RN   [7]
RC   Protein update by submitter
RP   1-576874
RG   Saccharomyces Genome Database
RA   ;
RT   ;
RL   Submitted (16-JAN-2015) to the INSDC.
RL   Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA
XX
DR   MD5; d2787193198c8d260f58f2097f9e1e39.
DR   Ensembl-Gn; YEL045C; saccharomyces_cerevisiae.
DR   Ensembl-Gn; YEL059W; saccharomyces_cerevisiae.
DR   Ensembl-Gn; YER090C-A; saccharomyces_cerevisiae.
DR   Ensembl-Gn; YER190C-B; saccharomyces_cerevisiae.
DR   Ensembl-Gn; YGR296C-B; saccharomyces_cerevisiae.
DR   Ensembl-Gn; YPL283W-B; saccharomyces_cerevisiae.
DR   Ensembl-Gn; YPR204C-A; saccharomyces_cerevisiae.
DR   Ensembl-Scaffolds; BK006939.2:1-576874; saccharomyces_cerevisiae.
DR   Ensembl-Scaffolds; V:1-576874; saccharomyces_cerevisiae.
DR   Ensembl-Tr; YEL045C_mRNA; saccharomyces_cerevisiae.
DR   Ensembl-Tr; YEL059W_mRNA; saccharomyces_cerevisiae.
DR   Ensembl-Tr; YER090C-A_mRNA; saccharomyces_cerevisiae.
DR   Ensembl-Tr; YER190C-B_mRNA; saccharomyces_cerevisiae.
DR   Ensembl-Tr; YGR296C-B_mRNA; saccharomyces_cerevisiae.
DR   Ensembl-Tr; YPL283W-B_mRNA; saccharomyces_cerevisiae.
DR   Ensembl-Tr; YPR204C-A_mRNA; saccharomyces_cerevisiae.
DR   EnsemblGenomes-Gn; ENSRNA049602867.
DR   EnsemblGenomes-Gn; ENSRNA049602938.
DR   EnsemblGenomes-Gn; ENSRNA049602989.
DR   EnsemblGenomes-Gn; ENSRNA049603060.
DR   EnsemblGenomes-Gn; ENSRNA049603111.
DR   EnsemblGenomes-Gn; ENSRNA049603141.
DR   EnsemblGenomes-Gn; ENSRNA049603172.
DR   EnsemblGenomes-Gn; ENSRNA049603196.
DR   EnsemblGenomes-Gn; ENSRNA049603241.
DR   EnsemblGenomes-Gn; ENSRNA049603282.
DR   EnsemblGenomes-Gn; ENSRNA049603320.
DR   EnsemblGenomes-Gn; ENSRNA049603357.
DR   EnsemblGenomes-Gn; ENSRNA049603414.
DR   EnsemblGenomes-Gn; ENSRNA049603434.
DR   EnsemblGenomes-Gn; ENSRNA049603449.
DR   EnsemblGenomes-Gn; ENSRNA049603465.
DR   EnsemblGenomes-Gn; ENSRNA049603509.
DR   EnsemblGenomes-Gn; ENSRNA049603535.
DR   EnsemblGenomes-Gn; ENSRNA049603577.
DR   EnsemblGenomes-Gn; ENSRNA049603609.
DR   EnsemblGenomes-Gn; ENSRNA049651861.
DR   EnsemblGenomes-Gn; ENSRNA049651872.
DR   EnsemblGenomes-Gn; ENSRNA049651897.
DR   EnsemblGenomes-Gn; ENSRNA049651917.
DR   EnsemblGenomes-Gn; ENSRNA049651929.
DR   EnsemblGenomes-Gn; ENSRNA049651940.
DR   EnsemblGenomes-Gn; RPR1.
DR   EnsemblGenomes-Gn; SCR1.
DR   EnsemblGenomes-Gn; SRG1.
DR   EnsemblGenomes-Gn; YEL009C-A.
DR   EnsemblGenomes-Gn; YEL018C-A.
DR   EnsemblGenomes-Gn; YEL020C-B.
DR   EnsemblGenomes-Gn; YEL050W-A.
DR   EnsemblGenomes-Gn; YEL053W-A.
DR   EnsemblGenomes-Gn; YEL077W-A.
DR   EnsemblGenomes-Gn; YER006C-A.
DR   EnsemblGenomes-Gn; YER038W-A.
DR   EnsemblGenomes-Gn; YER046W-A.
DR   EnsemblGenomes-Gn; YER067C-A.
DR   EnsemblGenomes-Gn; YER068C-A.
DR   EnsemblGenomes-Gn; YER076W-A.
DR   EnsemblGenomes-Gn; YER079C-A.
DR   EnsemblGenomes-Gn; YER084W-A.
DR   EnsemblGenomes-Gn; YER087C-A.
DR   EnsemblGenomes-Gn; YER088C-A.
DR   EnsemblGenomes-Gn; YER090C-A.
DR   EnsemblGenomes-Gn; YER107W-A.
DR   EnsemblGenomes-Gn; YER133W-A.
DR   EnsemblGenomes-Gn; YER137W-A.
DR   EnsemblGenomes-Gn; YER145C-A.
DR   EnsemblGenomes-Gn; YER147C-A.
DR   EnsemblGenomes-Gn; YER148W-A.
DR   EnsemblGenomes-Gn; YER152W-A.
DR   EnsemblGenomes-Gn; YER165C-A.
DR   EnsemblGenomes-Gn; YER172C-A.
DR   EnsemblGenomes-Gn; snR14.
DR   EnsemblGenomes-Gn; snR4.
DR   EnsemblGenomes-Gn; snR52.
DR   EnsemblGenomes-Gn; snR53.
DR   EnsemblGenomes-Gn; snR67.
DR   EnsemblGenomes-Gn; snR80.
DR   EnsemblGenomes-Gn; tA(UGC)E.
DR   EnsemblGenomes-Gn; tE(UUC)E1.
DR   EnsemblGenomes-Gn; tE(UUC)E2.
DR   EnsemblGenomes-Gn; tE(UUC)E3.
DR   EnsemblGenomes-Gn; tG(GCC)E.
DR   EnsemblGenomes-Gn; tH(GUG)E1.
DR   EnsemblGenomes-Gn; tH(GUG)E2.
DR   EnsemblGenomes-Gn; tI(AAU)E1.
DR   EnsemblGenomes-Gn; tI(AAU)E2.
DR   EnsemblGenomes-Gn; tK(CUU)E1.
DR   EnsemblGenomes-Gn; tK(CUU)E2.
DR   EnsemblGenomes-Gn; tM(CAU)E.
DR   EnsemblGenomes-Gn; tQ(UUG)E1.
DR   EnsemblGenomes-Gn; tQ(UUG)E2.
DR   EnsemblGenomes-Gn; tR(ACG)E.
DR   EnsemblGenomes-Gn; tR(UCU)E.
DR   EnsemblGenomes-Gn; tS(AGA)E.
DR   EnsemblGenomes-Gn; tS(UGA)E.
DR   EnsemblGenomes-Gn; tV(AAC)E1.
DR   EnsemblGenomes-Gn; tV(AAC)E2.
DR   EnsemblGenomes-Tr; RPR1.
DR   EnsemblGenomes-Tr; SCR1.
DR   EnsemblGenomes-Tr; SRG1.
DR   EnsemblGenomes-Tr; YEL009C-A.
DR   EnsemblGenomes-Tr; YEL018C-A.
DR   EnsemblGenomes-Tr; YEL020C-B.
DR   EnsemblGenomes-Tr; YEL050W-A.
DR   EnsemblGenomes-Tr; YEL053W-A.
DR   EnsemblGenomes-Tr; YEL077W-A.
DR   EnsemblGenomes-Tr; YER006C-A.
DR   EnsemblGenomes-Tr; YER038W-A.
DR   EnsemblGenomes-Tr; YER046W-A.
DR   EnsemblGenomes-Tr; YER067C-A.
DR   EnsemblGenomes-Tr; YER068C-A.
DR   EnsemblGenomes-Tr; YER076W-A.
DR   EnsemblGenomes-Tr; YER079C-A.
DR   EnsemblGenomes-Tr; YER084W-A.
DR   EnsemblGenomes-Tr; YER087C-A.
DR   EnsemblGenomes-Tr; YER088C-A.
DR   EnsemblGenomes-Tr; YER090C-A.
DR   EnsemblGenomes-Tr; YER107W-A.
DR   EnsemblGenomes-Tr; YER133W-A.
DR   EnsemblGenomes-Tr; YER137W-A.
DR   EnsemblGenomes-Tr; YER145C-A.
DR   EnsemblGenomes-Tr; YER147C-A.
DR   EnsemblGenomes-Tr; YER148W-A.
DR   EnsemblGenomes-Tr; YER152W-A.
DR   EnsemblGenomes-Tr; YER165C-A.
DR   EnsemblGenomes-Tr; YER172C-A.
DR   EnsemblGenomes-Tr; snR14.
DR   EnsemblGenomes-Tr; snR4.
DR   EnsemblGenomes-Tr; snR52.
DR   EnsemblGenomes-Tr; snR53.
DR   EnsemblGenomes-Tr; snR67.
DR   EnsemblGenomes-Tr; snR80.
DR   EnsemblGenomes-Tr; tA(UGC)E.
DR   EnsemblGenomes-Tr; tE(UUC)E1.
DR   EnsemblGenomes-Tr; tE(UUC)E2.
DR   EnsemblGenomes-Tr; tE(UUC)E3.
DR   EnsemblGenomes-Tr; tG(GCC)E.
DR   EnsemblGenomes-Tr; tH(GUG)E1.
DR   EnsemblGenomes-Tr; tH(GUG)E2.
DR   EnsemblGenomes-Tr; tI(AAU)E1.
DR   EnsemblGenomes-Tr; tI(AAU)E2.
DR   EnsemblGenomes-Tr; tK(CUU)E1.
DR   EnsemblGenomes-Tr; tK(CUU)E2.
DR   EnsemblGenomes-Tr; tM(CAU)E.
DR   EnsemblGenomes-Tr; tQ(UUG)E1.
DR   EnsemblGenomes-Tr; tQ(UUG)E2.
DR   EnsemblGenomes-Tr; tR(ACG)E.
DR   EnsemblGenomes-Tr; tR(UCU)E.
DR   EnsemblGenomes-Tr; tS(AGA)E.
DR   EnsemblGenomes-Tr; tS(UGA)E.
DR   EnsemblGenomes-Tr; tV(AAC)E1.
DR   EnsemblGenomes-Tr; tV(AAC)E2.
DR   EuropePMC; PMC4256929; 25160824.
DR   GOA; P0C5M8.
DR   GOA; P0CX95.
DR   GOA; P32616.
DR   GOA; P39982.
DR   RFAM; RF00005; tRNA.
DR   RFAM; RF00009; RNaseP_nuc.
DR   RFAM; RF00015; U4.
DR   RFAM; RF00338; snoR53.
DR   RFAM; RF01177; snR67.
DR   RFAM; RF01195; snR52.
DR   RFAM; RF01244; snR4.
DR   RFAM; RF01269; snR80.
DR   RFAM; RF01502; Fungi_SRP.
DR   RFAM; RF01765; srg1.
DR   StrainInfo; 317495; 0.
DR   UniProtKB/Swiss-Prot; P0C5M8; YE090_YEAST.
DR   UniProtKB/Swiss-Prot; P0CX95; YE07A_YEAST.
DR   UniProtKB/Swiss-Prot; P32616; YEF5_YEAST.
DR   UniProtKB/Swiss-Prot; P39982; HHY1_YEAST.
XX
CC   On Apr 18, 2011 this sequence version replaced BK006939.1.
CC   ##Genome-Annotation-Data-START##
CC   Annotation Provider :: SGD
CC   Annotation Status   :: Full Annotation
CC   Annotation Version  :: R64-2-1
CC   URL                 :: http://www.yeastgenome.org/
CC   ##Genome-Annotation-Data-END##
XX
AH   LOCAL_SPAN      PRIMARY_IDENTIFIER   PRIMARY_SPAN   COMP
AS   1-5957          U73806.1             1-5957
AS   2478-53326      U18795.1             1-50849
AS   53027-89898     U18779.1             1-36872
AS   89595-152238    U18530.1             1-62643
AS   151911-217940   U18778.1             1-66030
AS   217761-260860   U18796.1             1-43100
AS   260660-303236   U18813.1             1-42576
AS   303077-311521   U18814.1             1-8443
AS   310018-374814   U18839.1             1-64797
AS   374115-442415   U18916.2             1-68301
AS   442016-509899   U18917.1             1-67883
AS   509650-573693   U18922.1             1-64044
AS   570910-576874   U34775.1             1-5965
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..576874
FT                   /organism="Saccharomyces cerevisiae S288C"
FT                   /chromosome="V"
FT                   /strain="S288C"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:559292"
FT   telomere        complement(1..6473)
FT                   /note="TEL05L; Telomeric region on the left arm of
FT                   Chromosome V; annotated components include an X element
FT                   core sequence and a long Y' element; TEL05L does have
FT                   telomeric repeats (TEL05L-TR), but they are missing from
FT                   the genome annotation due to difficulties encountered
FT                   during sequencing and/or assembly"
FT   gene            complement(264..4097)
FT                   /locus_tag="YEL077C"
FT   mRNA            complement(264..4097)
FT                   /locus_tag="YEL077C"
FT                   /product="Y' element ATP-dependent helicase"
FT   CDS_pept        complement(264..4097)
FT                   /codon_start=1
FT                   /locus_tag="YEL077C"
FT                   /product="Y' element ATP-dependent helicase"
FT                   /EC_number="3.6.4.12"
FT                   /note="Helicase-like protein encoded within the telomeric
FT                   Y' element"
FT                   /db_xref="EnsemblGenomes-Gn:YEL077C"
FT                   /db_xref="EnsemblGenomes-Tr:YEL077C"
FT                   /db_xref="GOA:Q3E7X8"
FT                   /db_xref="InterPro:IPR001650"
FT                   /db_xref="InterPro:IPR014001"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q3E7X8"
FT                   /protein_id="DAA07578.1"
FT                   /translation="MTLGNSYDAFNHDPWMDVVGFEDPNQVTNRDISRIVLYSYMFLNT
FT                   AKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSEL
FT                   MANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNA
FT                   EDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCYE
FT                   IYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLGR
FT                   CGCLNVAPVRNFIEEGYDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLG
FT                   YLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLA
FT                   KKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIRKKVESQPEEALKLL
FT                   LALFESEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLDAAEKVSRTKEFVTDGN
FT                   MRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAAR
FT                   NRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLA
FT                   EKQATASMSIVALPSNFQESNSSDRYRKYCSSDEDSNTCIHGSANASTNASTNAITTAS
FT                   TNVRTNATTNASTNATTNASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTE
FT                   STNSSTNATTTASINVRTSATTTKSINSSTNATITESTNSNTNATTTESTNSKTSATTT
FT                   ASTNSNTSATTTESTNSKTSATTTASTNSNTSATTTESTNSNTSATTTASTNSSTNATT
FT                   TESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSEN
FT                   MNVLQFLGFRSDEIKHLFLYGIDIYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYR
FT                   RMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRREIYSQIQRNYAWYL
FT                   AITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEK
FT                   KCQEEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELS
FT                   LGMHLRDQIALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWLD
FT                   LANVEVLAADNTKVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE"
FT   rep_origin      4097..4185
FT                   /note="ARS502; Autonomously Replicating Sequence"
FT   gene            complement(4185..5114)
FT                   /locus_tag="YEL076C-A"
FT   mRNA            complement(join(4185..4322,4602..5114))
FT                   /locus_tag="YEL076C-A"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(join(4185..4322,4602..5114))
FT                   /codon_start=1
FT                   /locus_tag="YEL076C-A"
FT                   /product="hypothetical protein"
FT                   /db_xref="GOA:P0CX16"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CX16"
FT                   /protein_id="DAA07579.1"
FT                   /translation="MQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRL
FT                   GDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRR
FT                   LRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETTLKDSYRITL
FT                   VPSSDGISDTLTVIQSFSYSLLPVLSATYTSMIQQDASNCTLITTRTVHRSLD"
FT   gene            complement(4464..5114)
FT                   /locus_tag="YEL076C"
FT   mRNA            complement(4464..5114)
FT                   /locus_tag="YEL076C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(4464..5114)
FT                   /codon_start=1
FT                   /locus_tag="YEL076C"
FT                   /product="hypothetical protein"
FT                   /db_xref="GOA:P39971"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39971"
FT                   /protein_id="DAA07580.1"
FT                   /translation="MQASLPGEKKVDTERLKRDLCPRKPIEIKYFSQICNDMMNKKDRL
FT                   GDILHIILRACALNFGAGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRR
FT                   LRKTLDAVKALLVSSCACTARDLDIFDDNNGVAMWKWIKILYHEVAQETTLKDSYRITL
FT                   VPSSDGISVCGKLWGELNNCFHMPASFCVIEKFCSENRSEELTSIWKTILFFK"
FT   gene            complement(5345..5713)
FT                   /locus_tag="YEL075C"
FT   mRNA            complement(5345..5713)
FT                   /locus_tag="YEL075C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(5345..5713)
FT                   /codon_start=1
FT                   /locus_tag="YEL075C"
FT                   /product="hypothetical protein"
FT                   /db_xref="GOA:P39972"
FT                   /db_xref="InterPro:IPR021646"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39972"
FT                   /protein_id="DAA07581.1"
FT                   /translation="MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRS
FT                   FYEDEKSGLIKVVKFRTGAMDRKRSFEKVVISVMVGKNVKKFLTFVEDEPDFQGGPIPS
FT                   NKPRDGLHVVSSAYFEIQ"
FT   rep_origin      6378..6453
FT                   /note="ARS503; Autonomously Replicating Sequence"
FT   gene            complement(7230..7553)
FT                   /locus_tag="YEL073C"
FT   mRNA            complement(7230..7553)
FT                   /locus_tag="YEL073C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(7230..7553)
FT                   /codon_start=1
FT                   /locus_tag="YEL073C"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; located adjacent to ARS503 and
FT                   the telomere on the left arm of chromosome V; regulated by
FT                   inositol/choline"
FT                   /db_xref="GOA:P39974"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39974"
FT                   /protein_id="DAA07582.1"
FT                   /translation="MVNLANVLTNATAATLSAWSNTVPLETYFHFDEASGFGDYYLNVS
FT                   VIWMNETLYETRIVPAIINVREWLDHMEANDPSPSVTNPYETSGYYAFSTVVPVLMGNM
FT                   KVA"
FT   rep_origin      8786..10019
FT                   /note="ARS504; Autonomously Replicating Sequence"
FT   gene            13720..14415
FT                   /gene="RMD6"
FT                   /locus_tag="YEL072W"
FT   mRNA            13720..14415
FT                   /gene="RMD6"
FT                   /locus_tag="YEL072W"
FT                   /product="Rmd6p"
FT   CDS_pept        13720..14415
FT                   /codon_start=1
FT                   /gene="RMD6"
FT                   /locus_tag="YEL072W"
FT                   /product="Rmd6p"
FT                   /note="Protein required for sporulation"
FT                   /db_xref="GOA:P39975"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39975"
FT                   /protein_id="DAA07583.1"
FT                   /translation="MSACPCNIVILPVEILKNSSKDTKYSLYTTINRGYDVPRLKYGII
FT                   VSPRVHSLETLFSDLGFDKNIEKSSLYLLLNDPTLAYPNFHEHFEQLKGETNKDLSLPT
FT                   YYIPKVQFLTEAFDSEHTLATIGYKPNNKESYEITGFTSMGNGYGIKLFNYSVIHMMRS
FT                   HKCKRVVADIIMEHDLLGYYEKKLGFVEVQRFKVLKEQHQVKVFDDKVDFTKDFHVIKM
FT                   IKELGNHRL"
FT   gene            16355..17845
FT                   /gene="DLD3"
FT                   /locus_tag="YEL071W"
FT   mRNA            16355..17845
FT                   /gene="DLD3"
FT                   /locus_tag="YEL071W"
FT                   /product="D-lactate dehydrogenase"
FT   CDS_pept        16355..17845
FT                   /codon_start=1
FT                   /gene="DLD3"
FT                   /locus_tag="YEL071W"
FT                   /product="D-lactate dehydrogenase"
FT                   /EC_number="1.1.2.4"
FT                   /EC_number="1.1.99.40"
FT                   /note="2-hydroxyglutarate transhydrogenase, and minor
FT                   D-lactate dehydrogenase; converts D-2-hydroxyglutarate
FT                   (D-2HG), an oncometabolite, to alpha-ketoglutarate in the
FT                   presence of FAD, with concomitant reduction of pyruvate to
FT                   D-lactate; minor lactate dehydrogenase activity; component
FT                   of the retrograde regulon that consists of genes whose
FT                   expression are stimulated by damage to mitochondria and
FT                   reduced in cells grown with glutamate as the sole nitrogen
FT                   source; located in the cytoplasm"
FT                   /db_xref="GOA:P39976"
FT                   /db_xref="InterPro:IPR004113"
FT                   /db_xref="InterPro:IPR006094"
FT                   /db_xref="InterPro:IPR016164"
FT                   /db_xref="InterPro:IPR016166"
FT                   /db_xref="InterPro:IPR016167"
FT                   /db_xref="InterPro:IPR016169"
FT                   /db_xref="InterPro:IPR016171"
FT                   /db_xref="InterPro:IPR036318"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39976"
FT                   /experiment="EXISTENCE:direct assay:GO:0004458 D-lactate
FT                   dehydrogenase (cytochrome) activity [PMID:10509019]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:10509019|PMID:11914276]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071949 FAD binding
FT                   [PMID:26774271]"
FT                   /experiment="EXISTENCE:direct assay:GO:0099615
FT                   (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity
FT                   [PMID:26774271]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0019249 lactate
FT                   biosynthetic process [PMID:26774271]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030447
FT                   filamentous growth [PMID:16999827]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0099615
FT                   (D)-2-hydroxyglutarate-pyruvate transhydrogenase activity
FT                   [PMID:26774271]"
FT                   /protein_id="DAA07584.1"
FT                   /translation="MTAAHPVAQLTAEAYPKVKRNPNFKVLDSEDLAYFRSILSNDEIL
FT                   NSQAPEELASFNQDWMKKYRGQSNLILLPNSTDKVSKIMKYCNDKKLAVVPQGGNTDLV
FT                   GASVPVFDEIVLSLRNMNKVRDFDPVSGTFKCDAGVVMRDAHQFLHDHDHIFPLDLPSR
FT                   NNCQVGGVVSTNAGGLNFLRYGSLHGNVLGLEVVLPNGEIISNINALRKDNTGYDLKQL
FT                   FIGAEGTIGVVTGVSIVAAAKPKALNAVFFGIENFDTVQKLFVKAKSELSEILSAFEFM
FT                   DRGSIECTIEYLKDLPFPLENQHNFYVLIETSGSNKRHDDEKLTAFLKDTTDSKLISEG
FT                   MMAKDKADFDRLWTWRKSVPTACNSYGGMYKYDMSLQLKDLYSVSAAVTERLNAAGLIG
FT                   DAPKPVVKSCGYGHVGDGNIHLNIAVREFTKQIEDLLEPFVYEYIASKKGSISAEHGIG
FT                   FHKKGKLHYTRSDIEIRFMKDIKNHYDPNGILNPYKYI"
FT   gene            19589..21097
FT                   /gene="DSF1"
FT                   /gene_synonym="MAN1"
FT                   /locus_tag="YEL070W"
FT   mRNA            19589..21097
FT                   /gene="DSF1"
FT                   /gene_synonym="MAN1"
FT                   /locus_tag="YEL070W"
FT                   /product="mannitol dehydrogenase DSF1"
FT   CDS_pept        19589..21097
FT                   /codon_start=1
FT                   /gene="DSF1"
FT                   /gene_synonym="MAN1"
FT                   /locus_tag="YEL070W"
FT                   /product="mannitol dehydrogenase DSF1"
FT                   /note="Mannitol dehydrogenase; deletion suppresses mutation
FT                   of mpt5; DSF1 has a paralog, MAN2, that arose from a
FT                   segmental duplication"
FT                   /db_xref="GOA:P0CX08"
FT                   /db_xref="InterPro:IPR000669"
FT                   /db_xref="InterPro:IPR008927"
FT                   /db_xref="InterPro:IPR013118"
FT                   /db_xref="InterPro:IPR013131"
FT                   /db_xref="InterPro:IPR013328"
FT                   /db_xref="InterPro:IPR023027"
FT                   /db_xref="InterPro:IPR036291"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CX08"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0046029 mannitol
FT                   dehydrogenase activity [PMID:26996892]"
FT                   /protein_id="DAA07585.1"
FT                   /translation="MTKSDETTATSLNAKTLKSFESTLPIPTYPREGVKQGIVHLGVGA
FT                   FHRSHLAVFMHRLMQEHHLKDWSICGVGLMKADALMRDAMKAQDCLYTLVERGIKDTNA
FT                   YIVGSITAYMYAPDDPRAVIEKMANPDTHIVSLTVTENGYYHSEATNSLMTDAPEIIND
FT                   LNHPEKPDTLYGYLYEALLLRYKRGLTPFTIMSCDNMPQNGVTVKTMLVAFAKLKKDEK
FT                   FAAWIEDKVTSPNSMVDRVTPRCTDKERKYVADTWGIKDQCPVVAEPFIQWVLEDNFSD
FT                   GRPPWELVGVQVVKDVDSYELMKLRLLNGGHSAMGYLGYLAGYTYIHEVVNDPTINKYI
FT                   RVLMREEVIPLLPKVPGVDFEEYTASVLERFSNPAIQDTVARICLMGSGKMPKYVLPSI
FT                   YEQLRKPDGKYKLLAVCVAGWFRYLTGVDMNGKPFEIEDPMAPTLKAAAVKGGKDPHEL
FT                   LNIEVLFSPEIRDNKEFVAQLTHSLETVYDKGPIAAIKEILDQV"
FT   gene            complement(21537..23231)
FT                   /gene="HXT13"
FT                   /gene_synonym="HLT1"
FT                   /locus_tag="YEL069C"
FT   mRNA            complement(21537..23231)
FT                   /gene="HXT13"
FT                   /gene_synonym="HLT1"
FT                   /locus_tag="YEL069C"
FT                   /product="hexose transporter HXT13"
FT   CDS_pept        complement(21537..23231)
FT                   /codon_start=1
FT                   /gene="HXT13"
FT                   /gene_synonym="HLT1"
FT                   /locus_tag="YEL069C"
FT                   /product="hexose transporter HXT13"
FT                   /note="Putative transmembrane polyol transporter; supports
FT                   growth on and uptake of mannitol and sorbitol with moderate
FT                   affinity when overexpressed in a strain deleted for hexose
FT                   family members; minor hexose transport activity when
FT                   overexpressed in a similar strain; induced by
FT                   non-fermentable carbon sources; induced in low glucose,
FT                   repressed in high glucose; HXT13 has a paralog, HXT17, that
FT                   arose from a segmental duplication"
FT                   /db_xref="GOA:P39924"
FT                   /db_xref="InterPro:IPR003663"
FT                   /db_xref="InterPro:IPR005828"
FT                   /db_xref="InterPro:IPR005829"
FT                   /db_xref="InterPro:IPR020846"
FT                   /db_xref="InterPro:IPR036259"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39924"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0015795
FT                   sorbitol transport [PMID:26996892]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0015797
FT                   mannitol transport [PMID:26996892]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose
FT                   transmembrane transporter activity [PMID:10618490]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005355 glucose
FT                   transmembrane transporter activity [PMID:10618490]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose
FT                   transmembrane transport [PMID:10618490]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose
FT                   transmembrane transporter activity [PMID:10618490]"
FT                   /protein_id="DAA07586.1"
FT                   /translation="MSSAQSSIDSDGDVRDADIHVAPPVEKEWSDGFDDNEVINGDNVE
FT                   PPKRGLIGYLVIYLLCYPISFGGFLPGWDSGITAGFINMDNFKMNFGSYKHSTGEYYLS
FT                   NVRMGLLVAMFSIGCAIGGLIFARLADTLGRRLAIVIVVLVYMVGAIIQISSNHKWYQY
FT                   FVGKIIYGLGAGGCSVLCPMLLSEIAPTDLRGGLVSLYQLNMTFGIFLGYCSVYGTRKY
FT                   DNTAQWRVPLGLCFLWALIIIIGMLLVPESPRYLIECERHEEARASIAKINKVSPEDPW
FT                   VLKQADEINAGVLAQRELGEASWKELFSVKTKVLQRLITGILVQTFLQLTGENYFFFYG
FT                   TTIFKSVGLTDGFETSIVLGTVNFFSTIIAVMVVDKIGRRKCLLFGAAGMMACMVIFAS
FT                   IGVKCLYPHGQDGPSSKGAGNAMIVFTCFYIFCFATTWAPVAYIVVAESFPSKVKSRAM
FT                   SISTACNWLWQFLIGFFTPFITGSIHFYYGYVFVGCLVAMFLYVFFFLPETIGLSLEEI
FT                   QLLYEEGIKPWKSASWVPPSRRGISSEESKTEKKDWKKFLKFSKNSD"
FT   gene            complement(25646..25978)
FT                   /locus_tag="YEL068C"
FT   mRNA            complement(25646..25978)
FT                   /locus_tag="YEL068C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(25646..25978)
FT                   /codon_start=1
FT                   /locus_tag="YEL068C"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; expressed at both mRNA and
FT                   protein levels; SWAT-GFP and seamless-GFP fusion proteins
FT                   localize to the endoplasmic reticulum and mCherry fusion
FT                   protein localizes to the vacuole"
FT                   /db_xref="GOA:P39977"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39977"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /protein_id="DAA35102.1"
FT                   /translation="MKILALAVAFQGLALVCCTDTTDNYNNFTHNTSTFYRIADYDKRF
FT                   WSVKLPPVNWTTCGNEDHPWITIHYDEIDKLVDDKLASWDKGPVPDREEFRNSILRQAR
FT                   CDRPHY"
FT   gene            complement(26189..26776)
FT                   /locus_tag="YEL067C"
FT   mRNA            complement(26189..26776)
FT                   /locus_tag="YEL067C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(26189..26776)
FT                   /codon_start=1
FT                   /locus_tag="YEL067C"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; the authentic, non-tagged
FT                   protein is detected in highly purified mitochondria in
FT                   high-throughput studies"
FT                   /db_xref="GOA:P39978"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39978"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /protein_id="DAA07587.1"
FT                   /translation="MAFTTIRSLTIFSGSSFDMPTFFVLAKGGDGSGVFFISLHSSILY
FT                   ARFPLLNILSQHSPVYCSRRFPPDNDLITGLGNIRCGQLVKKALRRVCNVPPDHQLIAS
FT                   VRSIGYARVAFVFCTCTSECRDNLQSVTRTSGHQTTISQPCTDIQSTRKCSTIFVSAVM
FT                   QTGTITFFWTFHFPIPLQRIVNQKQPPPQSYV"
FT   gene            26667..27206
FT                   /gene="HPA3"
FT                   /locus_tag="YEL066W"
FT   mRNA            26667..27206
FT                   /gene="HPA3"
FT                   /locus_tag="YEL066W"
FT                   /product="D-amino-acid N-acetyltransferase"
FT   CDS_pept        26667..27206
FT                   /codon_start=1
FT                   /gene="HPA3"
FT                   /locus_tag="YEL066W"
FT                   /product="D-amino-acid N-acetyltransferase"
FT                   /EC_number="2.3.1.36"
FT                   /EC_number="2.3.1.48"
FT                   /note="D-Amino acid N-acetyltransferase that detoxifies
FT                   D-amino acids; catalyzes N-acetylation of D-amino acids
FT                   through ordered bi-bi mechanism in which acetyl-CoA is
FT                   first substrate bound and CoA is last product liberated;
FT                   acetylates histones and polyamines, also autoacetylates"
FT                   /db_xref="GOA:P39979"
FT                   /db_xref="InterPro:IPR000182"
FT                   /db_xref="InterPro:IPR016181"
FT                   /db_xref="InterPro:IPR032962"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39979"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006473 protein
FT                   acetylation [PMID:23775086]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008080
FT                   N-acetyltransferase activity [PMID:23775086]"
FT                   /experiment="EXISTENCE:direct assay:GO:0047812 D-amino-acid
FT                   N-acetyltransferase activity [PMID:15375647]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0046416 D-amino
FT                   acid metabolic process [PMID:16362288]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0070458 cellular
FT                   detoxification of nitrogen compound
FT                   [PMID:16362288|PMID:23775086]"
FT                   /protein_id="DAA07588.1"
FT                   /translation="MKKTPDPSPPFASTKNVGMSNEEPEKMVNDRIVVKAIEPKDEEAW
FT                   NKLWKEYQGFQKTVMPPEVATTTFARFIDPTVKLWGALAFDTETGDAIGFAHYLNHLTS
FT                   WHVEEVVYMNDLYVTERARVKGVGRKLIEFVYSRADELGTPAVYWVTDHYNHRAQLLYT
FT                   KVAYKTDKVLYKRNGY"
FT   gene            27657..29543
FT                   /gene="SIT1"
FT                   /gene_synonym="ARN3"
FT                   /locus_tag="YEL065W"
FT   mRNA            27657..29543
FT                   /gene="SIT1"
FT                   /gene_synonym="ARN3"
FT                   /locus_tag="YEL065W"
FT                   /product="siderophore transporter"
FT   CDS_pept        27657..29543
FT                   /codon_start=1
FT                   /gene="SIT1"
FT                   /gene_synonym="ARN3"
FT                   /locus_tag="YEL065W"
FT                   /product="siderophore transporter"
FT                   /note="Ferrioxamine B transporter; member of the ARN family
FT                   of transporters that specifically recognize
FT                   siderophore-iron chelates; transcription is induced during
FT                   iron deprivation and diauxic shift; potentially
FT                   phosphorylated by Cdc28p"
FT                   /db_xref="GOA:P39980"
FT                   /db_xref="InterPro:IPR001411"
FT                   /db_xref="InterPro:IPR036259"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39980"
FT                   /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
FT                   vacuole [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005768 endosome
FT                   [PMID:19469713]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006879 cellular
FT                   iron ion homeostasis [PMID:9884238]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031410 cytoplasmic
FT                   vesicle [PMID:10748025]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006879 cellular
FT                   iron ion homeostasis [PMID:9884238]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015344
FT                   siderophore uptake transmembrane transporter activity
FT                   [PMID:9884238]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015891
FT                   siderophore transport [PMID:9884238]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0055085
FT                   transmembrane transport [PMID:9884238]"
FT                   /protein_id="DAA07589.1"
FT                   /translation="MDPGIANHTLPEEFEEVVVPEMLEKEVGAKVDVKPTLTTSSPAPS
FT                   YIELIDPGVHNIEIYAEMYNRPIYRVALFFSLFLIAYAYGLDGNIRYTFQAYATSSYSQ
FT                   HSLLSTVNCIKTVIAAVGQIFFARLSDIFGRFSIMIVSIIFYSMGTIIESQAVNITRFA
FT                   VGGCFYQLGLTGIILILEVIASDFSNLNWRLLALFIPALPFIINTWISGNVTSAIDANW
FT                   KWGIGMWAFILPLACIPLGICMLHMRYLARKHAKDRLKPEFEALNKLKWKSFCIDIAFW
FT                   KLDIIGMLLITVFFGCVLVPFTLAGGLKEEWKTAHIIVPEVIGWVVVLPLYMLWEIKYS
FT                   RHPLTPWDLIQDRGIFFALLIAFFINFNWYMQGDYMYTVLVVAVHESIKSATRITSLYS
FT                   FVSVIVGTILGFILIKVRRTKPFIIFGISCWIVSFGLLVHYRGDSGAHSGIIGSLCLLG
FT                   FGAGSFTYVTQASIQASAKTHARMAVVTSLYLATYNIGSAFGSSVSGAVWTNILPKEIS
FT                   KRISDPTLAAQAYGSPFTFITTYTWGTPERIALVMSYRYVQKILCIIGLVFCFPLLGCA
FT                   FMLRNHKLTDSIALEGNDHLESKNTFEIEEKEESFLKNKFFTHFTSSKDRKD"
FT   gene            complement(29797..31239)
FT                   /gene="AVT2"
FT                   /locus_tag="YEL064C"
FT   mRNA            complement(29797..31239)
FT                   /gene="AVT2"
FT                   /locus_tag="YEL064C"
FT                   /product="Avt2p"
FT   CDS_pept        complement(29797..31239)
FT                   /codon_start=1
FT                   /gene="AVT2"
FT                   /locus_tag="YEL064C"
FT                   /product="Avt2p"
FT                   /note="Putative transporter; member of a family of seven S.
FT                   cerevisiae genes (AVT1-7) related to vesicular GABA-glycine
FT                   transporters"
FT                   /db_xref="GOA:P39981"
FT                   /db_xref="InterPro:IPR013057"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39981"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:11274162]"
FT                   /protein_id="DAA07590.1"
FT                   /translation="MSELGEYSKLENKELRTEFELTNFPFPGTTDNDSDDGSQGQNSLN
FT                   IITPDMDDTLVNDVLRENDKKSSMRMAFMNLANSILGAGIITQPFAIKNAGILGGLLSY
FT                   VALGFIVDWTLRLIVINLTLAGKRTYQGTVEHVMGKKGKLLILFTNGLFAFGGCIGYCI
FT                   IIGDTIPHVLRAIFSQNDGNVHFWLRRNVIIVMVTTFISFPLSMKRNIEALSKASFLAV
FT                   ISMIIIVLTVVIRGPMLPYDWKGHSLKLSDFFMKATIFRSLSVISFALVCHHNTSFIFF
FT                   SMRNRSVAKFTRLTHISIIISVICCALMGYSGFAVFKEKTKGNVLNSFPGTDTAINIAR
FT                   LCFGFNMLTTFPMEIFVLRDVVGNLLHECNLIKNYDEHTQLSGKQHVVITSSLVFITMG
FT                   ISLTTCNLGALFELIGATTASTMAYILPPYTNLLLTSKKKSWKERLPFYLCICFGFMIM
FT                   IISSTQTIIDAVNGSDGQHCQI"
FT   gene            complement(31694..33466)
FT                   /gene="CAN1"
FT                   /locus_tag="YEL063C"
FT   mRNA            complement(31694..33466)
FT                   /gene="CAN1"
FT                   /locus_tag="YEL063C"
FT                   /product="arginine permease CAN1"
FT   CDS_pept        complement(31694..33466)
FT                   /codon_start=1
FT                   /gene="CAN1"
FT                   /locus_tag="YEL063C"
FT                   /product="arginine permease CAN1"
FT                   /note="Plasma membrane arginine permease; requires
FT                   phosphatidyl ethanolamine (PE) for localization,
FT                   exclusively associated with lipid rafts; mutation confers
FT                   canavanine resistance; CAN1 has a paralog, ALP1, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P04817"
FT                   /db_xref="InterPro:IPR002293"
FT                   /db_xref="InterPro:IPR004762"
FT                   /db_xref="InterPro:IPR004840"
FT                   /db_xref="InterPro:IPR004841"
FT                   /db_xref="UniProtKB/Swiss-Prot:P04817"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:15536122]"
FT                   /experiment="EXISTENCE:direct assay:GO:0015174 basic amino
FT                   acid transmembrane transporter activity [PMID:10654085]"
FT                   /experiment="EXISTENCE:direct assay:GO:0015802 basic amino
FT                   acid transport [PMID:10654085]"
FT                   /experiment="EXISTENCE:direct assay:GO:0032126 eisosome
FT                   [PMID:29402931]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045121 membrane
FT                   raft [PMID:15536122]"
FT                   /experiment="EXISTENCE:direct assay:GO:0055085
FT                   transmembrane transport [PMID:10654085]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0015809
FT                   arginine transport [PMID:23047103]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015181 arginine
FT                   transmembrane transporter activity [PMID:10753927]"
FT                   /protein_id="DAA07591.1"
FT                   /translation="MTNSKEDADIEEKHMYNEPVTTLFHDVEASQTHHRRGSIPLKDEK
FT                   SKELYPLRSFPTRVNGEDTFSMEDGIGDEDEGEVQNAEVKRELKQRHIGMIALGGTIGT
FT                   GLFIGLSTPLTNAGPVGALISYLFMGSLAYSVTQSLGEMATFIPVTSSFTVFSQRFLSP
FT                   AFGAANGYMYWFSWAITFALELSVVGQVIQFWTYKVPLAAWISIFWVIITIMNLFPVKY
FT                   YGEFEFWVASIKVLAIIGFLIYCFCMVCGAGVTGPVGFRYWRNPGAWGPGIISKDKNEG
FT                   RFLGWVSSLINAAFTFQGTELVGITAGEAANPRKSVPRAIKKVVFRILTFYIGSLLFIG
FT                   LLVPYNDPKLTQSTSYVSTSPFIIAIENSGTKVLPHIFNAVILTTIISAANSNIYVGSR
FT                   ILFGLSKNKLAPKFLSRTTKGGVPYIAVFVTAAFGALAYMETSTGGDKVFEWLLNITGV
FT                   AGFFAWLFISISHIRFMQALKYRGISRDELPFKAKLMPGLAYYAATFMTIIIIIQGFTA
FT                   FAPKFNGVSFAAAYISIFLFLAVWILFQCIFRCRFIWKIGDVDIDSDRRDIEAIVWEDH
FT                   EPKTFWDKFWNVVA"
FT   gene            34407..36254
FT                   /gene="NPR2"
FT                   /locus_tag="YEL062W"
FT   mRNA            34407..36254
FT                   /gene="NPR2"
FT                   /locus_tag="YEL062W"
FT                   /product="nitrogen permease regulating protein NPR2"
FT   CDS_pept        34407..36254
FT                   /codon_start=1
FT                   /gene="NPR2"
FT                   /locus_tag="YEL062W"
FT                   /product="nitrogen permease regulating protein NPR2"
FT                   /note="Subunit of the Iml1p/SEACIT complex; SEACIT
FT                   (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a
FT                   coatomer-related complex that associates dynamically with
FT                   the vacuole; Npr2p may have a structural or regulatory
FT                   role, supporting Iml1p function as a GAP for the Rag family
FT                   GTPase Gtr1p, and resulting in inhibition of TORC1
FT                   signaling in response to amino acid deprivation; SEACIT is
FT                   required for non-nitrogen-starvation-induced autophagy;
FT                   homolog of human tumor suppressor NPRL2"
FT                   /db_xref="GOA:P39923"
FT                   /db_xref="InterPro:IPR009348"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39923"
FT                   /experiment="EXISTENCE:direct assay:GO:0035859
FT                   Seh1-associated complex [PMID:21454883]"
FT                   /experiment="EXISTENCE:direct assay:GO:0097042 extrinsic
FT                   component of fungal-type vacuolar membrane [PMID:21454883]"
FT                   /experiment="EXISTENCE:direct assay:GO:1990130 GATOR1
FT                   complex [PMID:21900499]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0010508
FT                   positive regulation of autophagy [PMID:25046117]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:1904262
FT                   negative regulation of TORC1 signaling
FT                   [PMID:23716719|PMID:25046117]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular
FT                   response to nitrogen starvation [PMID:20154027]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive
FT                   regulation of autophagy [PMID:25046117]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015824 proline
FT                   transport [PMID:7867803]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015840 urea
FT                   transport [PMID:7867803]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0033138 positive
FT                   regulation of peptidyl-serine phosphorylation
FT                   [PMID:24476960]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042493 response
FT                   to drug [PMID:12869630]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1903833 positive
FT                   regulation of cellular response to amino acid starvation
FT                   [PMID:19521502]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative
FT                   regulation of TORC1 signaling
FT                   [PMID:19521502|PMID:23716719|PMID:25046117]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000785
FT                   regulation of autophagosome assembly [PMID:21900499]"
FT                   /protein_id="DAA07592.1"
FT                   /translation="MLSYFQGFVPIHTIFYSVFHPTEGSKIKYEFPPNNLKNHGINFNT
FT                   FKNYIIPKPILCHKLITFKYGTYRIVCYPVTINSPIYARNFFSFNFVFVFPYDCETSPY
FT                   EPAITRLGKMFKVLEEQNQLLSKSERDPVFFDLKVLENSTTTPSTAGPSSTPNPSSNTT
FT                   PTHPTSEKDTKDMRSSRYSDLIKDLGLPQSAFSIQDLLMRIFQDLNNYSECLIPIDEGN
FT                   AVDIKIFPLLRPPTTCVSLEDVPLSSVNLKKIIDVNWDPTMMSIVPYIDGLNSIAKISK
FT                   LSNSDPGLVIECIRHLIYYKCVTLSDIFQFSNIYAPSSLIRNFLTDPLMASDCQSYVTF
FT                   PEVSKISNLPLNKSLGSGDQDSPSFSVRRKSKSSSIPSNPDSRTTSFSSTSRVSQNSSL
FT                   NSSFSSIYKDWRQSQTSCSSSNIHVINNRNRFLPTRSCLFDLYRSLSQGQTLKTWYESK
FT                   YMILKENNIDIRRFITFGLEKRIIYRCYSFPVMINAGSREPKEMTPIITKDLVNNDKLL
FT                   EKRNHNHLLSATGSRNTAQSGNLKPERPSKVSFEMQRVSSLATGKSTMPKLSDEEEGIL
FT                   EESIRNAETFDKICVLLSKPKLEVESYLNELGEFKVINS"
FT   gene            complement(36535..39537)
FT                   /gene="CIN8"
FT                   /gene_synonym="KSL2"
FT                   /gene_synonym="SDS15"
FT                   /locus_tag="YEL061C"
FT   mRNA            complement(36535..39537)
FT                   /gene="CIN8"
FT                   /gene_synonym="KSL2"
FT                   /gene_synonym="SDS15"
FT                   /locus_tag="YEL061C"
FT                   /product="kinesin motor protein CIN8"
FT   CDS_pept        complement(36535..39537)
FT                   /codon_start=1
FT                   /gene="CIN8"
FT                   /gene_synonym="KSL2"
FT                   /gene_synonym="SDS15"
FT                   /locus_tag="YEL061C"
FT                   /product="kinesin motor protein CIN8"
FT                   /note="Kinesin motor protein; involved in mitotic spindle
FT                   assembly and chromosome segregation"
FT                   /db_xref="GOA:P27895"
FT                   /db_xref="InterPro:IPR001752"
FT                   /db_xref="InterPro:IPR019821"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR027640"
FT                   /db_xref="InterPro:IPR036961"
FT                   /db_xref="UniProtKB/Swiss-Prot:P27895"
FT                   /experiment="EXISTENCE:direct assay:GO:0000778 condensed
FT                   nuclear chromosome kinetochore [PMID:11511347]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005828 kinetochore
FT                   microtubule [PMID:19041752]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005876 spindle
FT                   microtubule [PMID:11511347|PMID:1618897]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008569
FT                   ATP-dependent microtubule motor activity,
FT                   minus-end-directed [PMID:21350123]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008574
FT                   ATP-dependent microtubule motor activity, plus-end-directed
FT                   [PMID:21350123]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000070
FT                   mitotic sister chromatid segregation [PMID:7860634]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000073
FT                   mitotic spindle pole body separation
FT                   [PMID:1618897|PMID:1618910]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0003777
FT                   microtubule motor activity [PMID:1618910]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic
FT                   spindle elongation [PMID:23851487|PMID:9813090]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000073 mitotic
FT                   spindle pole body separation [PMID:1618897]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000235 astral
FT                   microtubule [PMID:19041752]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007019
FT                   microtubule depolymerization [PMID:19041752]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008569
FT                   ATP-dependent microtubule motor activity,
FT                   minus-end-directed [PMID:27216310]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0090307 mitotic
FT                   spindle assembly [PMID:23851487|PMID:9813090]"
FT                   /protein_id="DAA07593.1"
FT                   /translation="MPAENQNTGQDRSSNSISKNGNSQVGCHTVPNEELNITVAVRCRG
FT                   RNEREISMKSSVVVNVPDITGSKEISINTTGDTGITAQMNAKRYTVDKVFGPGASQDLI
FT                   FDEVAGPLFQDFIKGYNCTVLVYGMTSTGKTYTMTGDEKLYNGELSDAAGIIPRVLLKL
FT                   FDTLELQQNDYVVKCSFIELYNEELKDLLDSNSNGSSNTGFDGQFMKKLRIFDSSTANN
FT                   TTSNSASSSRSNSRNSSPRSLNDLTPKAALLRKRLRTKSLPNTIKQQYQQQQAVNSRNN
FT                   SSSNSGSTTNNASSNTNTNNGQRSSMAPNDQTNGIYIQNLQEFHITNAMEGLNLLQKGL
FT                   KHRQVASTKMNDFSSRSHTIFTITLYKKHQDELFRISKMNLVDLAGSENINRSGALNQR
FT                   AKEAGSINQSLLTLGRVINALVDKSGHIPFRESKLTRLLQDSLGGNTKTALIATISPAK
FT                   VTSEETCSTLEYASKAKNIKNKPQLGSFIMKDILVKNITMELAKIKSDLLSTKSKEGIY
FT                   MSQDHYKNLNSDLESYKNEVQECKREIESLTSKNALLVKDKLKSKETIQSQNCQIESLK
FT                   TTIDHLRAQLDKQHKTEIEISDFNNKLQKLTEVMQMALHDYKKRELDLNQKFEMHITKE
FT                   IKKLKSTLFLQLNTMQQESILQETNIQPNLDMIKNEVLTLMRTMQEKAELMYKDCVKKI
FT                   LNESPKFFNVVIEKIDIIRVDFQKFYKNIAENLSDISEENNNMKQYLKNHFFKNNHQEL
FT                   LNRHVDSTYENIEKRTNEFVENFKKVLNDHLDENKKLIMQNLTTATSAVIDQEMDLFEP
FT                   KRVKWENSFDLINDCDSMNNEFYNSMAATLSQIKSTVDTSSNSMNESISVMKGQVEESE
FT                   NAISLLKNNTKFNDQFEQLINKHNMLKDNIKNSITSTHSHITNVDDIYNTIENIMKNYG
FT                   NKENATKDEMIENILKEIPNLSKKMPLRLSNINSNSVQSVISPKKHAIEDENKSSENVD
FT                   NEGSRKMLKIE"
FT   gene            complement(40046..41953)
FT                   /gene="PRB1"
FT                   /gene_synonym="CVT1"
FT                   /locus_tag="YEL060C"
FT   mRNA            complement(40046..41953)
FT                   /gene="PRB1"
FT                   /gene_synonym="CVT1"
FT                   /locus_tag="YEL060C"
FT                   /product="proteinase B"
FT   CDS_pept        complement(40046..41953)
FT                   /codon_start=1
FT                   /gene="PRB1"
FT                   /gene_synonym="CVT1"
FT                   /locus_tag="YEL060C"
FT                   /product="proteinase B"
FT                   /EC_number="3.4.21.48"
FT                   /note="Vacuolar proteinase B (yscB) with H3 N-terminal
FT                   endopeptidase activity; serine protease of the subtilisin
FT                   family; involved in protein degradation in the vacuole and
FT                   required for full protein degradation during sporulation;
FT                   activity inhibited by Pbi2p; protein abundance increases in
FT                   response to DNA replication stress; PRB1 has a paralog,
FT                   YSP3, that arose from the whole genome duplication"
FT                   /db_xref="GOA:P09232"
FT                   /db_xref="InterPro:IPR000209"
FT                   /db_xref="InterPro:IPR010259"
FT                   /db_xref="InterPro:IPR015500"
FT                   /db_xref="InterPro:IPR022398"
FT                   /db_xref="InterPro:IPR023827"
FT                   /db_xref="InterPro:IPR023828"
FT                   /db_xref="InterPro:IPR034193"
FT                   /db_xref="InterPro:IPR036852"
FT                   /db_xref="InterPro:IPR037045"
FT                   /db_xref="UniProtKB/Swiss-Prot:P09232"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000425
FT                   pexophagy [PMID:31332264]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004252
FT                   serine-type endopeptidase activity
FT                   [PMID:377296|PMID:385314]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007039 protein
FT                   catabolic process in the vacuole
FT                   [PMID:2674123|PMID:385314]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular
FT                   response to starvation [PMID:2674123]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030435
FT                   sporulation resulting in formation of a cellular spore
FT                   [PMID:2674123]"
FT                   /protein_id="DAA07594.1"
FT                   /translation="MKLENTLFTLGALGSISAALVIPNLENAADHHELINKEDHHERPR
FT                   KVEFTKDDDEEPSDSEDKEHGKFHKKGRKGQDKESPEFNGKRASGSHGSAHEGGKGMKP
FT                   KHESSNDDDNDDKKKKPHHKGGCHENKVEEKKMKGKKVKGKKHHEKTLEKGRHHNRLAP
FT                   LVSTAQFNPDAISKIIPNRYIIVFKRGAPQEEIDFHKENVQQAQLQSVENLSAEDAFFI
FT                   STKDTSLSTSEAGGIQDSFNIDNLFSGYIGYFTQEIVDLIRQNPLVDFVERDSIVEATE
FT                   FDTQNSAPWGLARISHRERLNLGSFNKYLYDDDAGRGVTSYVIDTGVNINHKDFEKRAI
FT                   WGKTIPLNDEDLDGNGHGTHCAGTIASKHYGVAKNANVVAVKVLRSNGSGTMSDVVKGV
FT                   EYAAKAHQKEAQEKKKGFKGSTANMSLGGGKSPALDLAVNAAVEVGIHFAVAAGNENQD
FT                   ACNTSPASADKAITVGASTLSDDRAYFSNWGKCVDVFAPGLNILSTYIGSDDATATLSG
FT                   TSMASPHVAGLLTYFLSLQPGSDSEFFELGQDSLTPQQLKKKLIHYSTKDILFDIPEDT
FT                   PNVLIYNGGGQDLSAFWNDTKKSHSSGFKQELNMDEFIGSKTDLIFDQVRDILDKLNII
FT                   "
FT   gene            complement(42400..42624)
FT                   /gene="SOM1"
FT                   /locus_tag="YEL059C-A"
FT   mRNA            complement(42400..42624)
FT                   /gene="SOM1"
FT                   /locus_tag="YEL059C-A"
FT                   /product="Som1p"
FT   CDS_pept        complement(42400..42624)
FT                   /codon_start=1
FT                   /gene="SOM1"
FT                   /locus_tag="YEL059C-A"
FT                   /product="Som1p"
FT                   /note="Subunit of the mitochondrial inner membrane
FT                   peptidase (IMP); IMP is required for maturation of
FT                   mitochondrial proteins of the intermembrane space; Som1p
FT                   facilitates cleavage of a subset of substrates; contains
FT                   twin cysteine-x9-cysteine motifs"
FT                   /db_xref="GOA:Q05676"
FT                   /db_xref="InterPro:IPR024645"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q05676"
FT                   /experiment="EXISTENCE:curator inference:GO:0004175
FT                   endopeptidase activity [PMID:10821182]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005743
FT                   mitochondrial inner membrane [PMID:9604886]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006508
FT                   proteolysis [PMID:10821182]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0033108
FT                   mitochondrial respiratory chain complex assembly
FT                   [PMID:19703468]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0042720
FT                   mitochondrial inner membrane peptidase complex
FT                   [PMID:10821182]"
FT                   /protein_id="DAA07595.1"
FT                   /translation="MAPPTTIRTRDQALAPLATLDSQTNCRLKELVQWECQFKGAEYVC
FT                   SPFKRLFEHCIAPDKSATNYEVTDTYTNS"
FT   gene            43252..44925
FT                   /gene="PCM1"
FT                   /gene_synonym="AGM1"
FT                   /locus_tag="YEL058W"
FT   mRNA            43252..44925
FT                   /gene="PCM1"
FT                   /gene_synonym="AGM1"
FT                   /locus_tag="YEL058W"
FT                   /product="phosphoacetylglucosamine mutase PCM1"
FT   CDS_pept        43252..44925
FT                   /codon_start=1
FT                   /gene="PCM1"
FT                   /gene_synonym="AGM1"
FT                   /locus_tag="YEL058W"
FT                   /product="phosphoacetylglucosamine mutase PCM1"
FT                   /EC_number="5.4.2.3"
FT                   /note="Essential N-acetylglucosamine-phosphate mutase;
FT                   converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for
FT                   the biosynthesis of chitin and for the formation of
FT                   N-glycosylated mannoproteins and
FT                   glycosylphosphatidylinositol anchors"
FT                   /db_xref="GOA:P38628"
FT                   /db_xref="InterPro:IPR005843"
FT                   /db_xref="InterPro:IPR005844"
FT                   /db_xref="InterPro:IPR016055"
FT                   /db_xref="InterPro:IPR016066"
FT                   /db_xref="InterPro:IPR016657"
FT                   /db_xref="InterPro:IPR036900"
FT                   /db_xref="UniProtKB/Swiss-Prot:P38628"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:11914276|PMID:14562095]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004610
FT                   phosphoacetylglucosamine mutase activity [PMID:8174553]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034221
FT                   fungal-type cell wall chitin biosynthetic process
FT                   [PMID:8174553]"
FT                   /protein_id="DAA07596.1"
FT                   /translation="MKVDYEQLCKLYDDTCRTKNVQFSYGTAGFRTLAKNLDTVMFSTG
FT                   ILAVLRSLKLQGQYVGVMITASHNPYQDNGVKIVEPDGSMLLATWEPYAMQLANAASFA
FT                   TNFEEFRVELAKLIEHEKIDLNTTVVPHIVVGRDSRESSPYLLRCLTSSMASVFHAQVL
FT                   DLGCVTTPQLHYITDLSNRRKLEGDTAPVATEQDYYSFFIGAFNELFATYQLEKRLSVP
FT                   KLFIDTANGIGGPQLKKLLASEDWDVPAEQVEVINDRSDVPELLNFECGADYVKTNQRL
FT                   PKGLSPSSFDSLYCSFDGDADRVVFYYVDSGSKFHLLDGDKISTLFAKFLSKQLELAHL
FT                   EHSLKIGVVQTAYANGSSTAYIKNTLHCPVSCTKTGVKHLHHEAATQYDIGIYFEANGH
FT                   GTIIFSEKFHRTIKSELSKSKLNGDTLALRTLKCFSELINQTVGDAISDMLAVLATLAI
FT                   LKMSPMDWDEEYTDLPNKLVKCIVPDRSIFQTTDQERKLLNPVGLQDKIDLVVAKYPMG
FT                   RSFVRASGTEDAVRVYAECKDSSKLGQFCDEVVEHVKASA"
FT   gene            complement(45020..45721)
FT                   /gene="SDD1"
FT                   /locus_tag="YEL057C"
FT   mRNA            complement(45020..45721)
FT                   /gene="SDD1"
FT                   /locus_tag="YEL057C"
FT                   /product="Sdd1p"
FT   CDS_pept        complement(45020..45721)
FT                   /codon_start=1
FT                   /gene="SDD1"
FT                   /locus_tag="YEL057C"
FT                   /product="Sdd1p"
FT                   /note="hypothetical protein; overproduction suppresses
FT                   lethality due to expression of the dominant PET9 allele
FT                   AAC2-A128P; may have a role in telomere maintenance; target
FT                   of UME6 regulation"
FT                   /db_xref="GOA:P39983"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39983"
FT                   /protein_id="DAA07597.1"
FT                   /translation="MANDGIQRNDNRKGFKTVQFSAYSKEIDVIMKKISFLERNITQQL
FT                   DTLPHFPKTLPPNHKDCVSRKHRARRGWSSQLKNLLGIYSKEEIFTLDNLAATLHDQVL
FT                   KLQATLFPNAILKQVHLDNANIENKRILKEITYKYLSNENCKEENKFGTFIVKRIFFGD
FT                   LSLGVSVLINRIAFESATSSIMVVRSSFIESDFFYEDYLIFDCRAKRRKKLKRKILFIS
FT                   TTMNFNYQTKV"
FT   gene            47168..48373
FT                   /gene="HAT2"
FT                   /locus_tag="YEL056W"
FT   mRNA            47168..48373
FT                   /gene="HAT2"
FT                   /locus_tag="YEL056W"
FT                   /product="Hat2p"
FT   CDS_pept        47168..48373
FT                   /codon_start=1
FT                   /gene="HAT2"
FT                   /locus_tag="YEL056W"
FT                   /product="Hat2p"
FT                   /note="Subunit of the Hat1p-Hat2p histone acetyltransferase
FT                   complex; required for high affinity binding of the complex
FT                   to free histone H4, thereby enhancing Hat1p activity;
FT                   similar to human RbAp46 and 48; has a role in telomeric
FT                   silencing"
FT                   /db_xref="GOA:P39984"
FT                   /db_xref="InterPro:IPR001680"
FT                   /db_xref="InterPro:IPR015943"
FT                   /db_xref="InterPro:IPR017986"
FT                   /db_xref="InterPro:IPR019775"
FT                   /db_xref="InterPro:IPR022052"
FT                   /db_xref="InterPro:IPR036322"
FT                   /db_xref="PDB:4PSW"
FT                   /db_xref="PDB:4PSX"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39984"
FT                   /experiment="EXISTENCE:direct assay:GO:0000123 histone
FT                   acetyltransferase complex [PMID:8858151|PMID:9575221]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004402 histone
FT                   acetyltransferase activity [PMID:8858151]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14761951|PMID:9575221]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:8858151|PMID:9575221]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006333 chromatin
FT                   assembly or disassembly [PMID:8858151]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016573 histone
FT                   acetylation [PMID:8858151]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042393 histone
FT                   binding [PMID:8858151]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006348
FT                   chromatin silencing at telomere [PMID:10982821]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004402 histone
FT                   acetyltransferase activity [PMID:8858151|PMID:9575221]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016573 histone
FT                   acetylation [PMID:8858151|PMID:9575221]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0000123
FT                   histone acetyltransferase complex [PMID:8858151]"
FT                   /protein_id="DAA07598.1"
FT                   /translation="MENQEKPLSVDEEYDLWKSNVPLMYDFVSETRLTWPSLTVQWLPT
FT                   PVQELDGGFIKQELIIGTHTSGEEENYLKFAEINLPKEILSNEDPQEEAGEEYQSSLPA
FT                   PRSNIRITAKYEHEEEITRARYMPQDPNIVATINGQGTVFLYSRSEGLQSTLKFHKDNG
FT                   YALSFSTLVKGRLLSGSDDHTVALWEVGSGGDPTKPVRTWNDLHSDIINDNKWHNFNKD
FT                   LFGTVSEDSLLKINDVRANNTTIDTVKCPQPFNTLAFSHHSSNLLAAAGMDSYVYLYDL
FT                   RNMKEPLHHMSGHEDAVNNLEFSTHVDGVVVSSGSDNRLMMWDLKQIGAEQTPDDAEDG
FT                   VPELIMVHAGHRSSVNDFDLNPQIPWLVASAEEENILQVWKCSHSLPIVGGPPKVNKDI
FT                   IS"
FT   gene            complement(48471..51539)
FT                   /gene="POL5"
FT                   /locus_tag="YEL055C"
FT   mRNA            complement(48471..51539)
FT                   /gene="POL5"
FT                   /locus_tag="YEL055C"
FT                   /product="DNA-directed DNA polymerase"
FT   CDS_pept        complement(48471..51539)
FT                   /codon_start=1
FT                   /gene="POL5"
FT                   /locus_tag="YEL055C"
FT                   /product="DNA-directed DNA polymerase"
FT                   /EC_number="2.7.7.7"
FT                   /note="DNA Polymerase phi; has sequence similarity to the
FT                   human MybBP1A and weak sequence similarity to B-type DNA
FT                   polymerases, not required for chromosomal DNA replication;
FT                   required for the synthesis of rRNA"
FT                   /db_xref="GOA:P39985"
FT                   /db_xref="InterPro:IPR007015"
FT                   /db_xref="InterPro:IPR016024"
FT                   /db_xref="InterPro:IPR017964"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39985"
FT                   /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding
FT                   [PMID:12093911]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:12093911|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary
FT                   transcript binding [PMID:31413149]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009303 rRNA
FT                   transcription [PMID:12093911]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030685
FT                   nucleolar preribosome [PMID:31413149]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0090070 positive
FT                   regulation of ribosome biogenesis [PMID:31413149]"
FT                   /protein_id="DAA07599.1"
FT                   /translation="MTGKVNRDLFFKLASDLREERLHAAVALIKDLSALDLPDDAEEWS
FT                   YVLNRLIKGLSSDRNSARLGFSLCLTEVINLAVNMPPGQRPKGLESTNEFLSTLSTILN
FT                   VNVNEGTKKSMKGKDERGILFGKLFGLKSLLNEPLFSEIFVKDLEKGNTEFFIRFTEQL
FT                   IDLALKKNWIKEPCFFTLFQTMKMLLPFMDESSAEKILLIYDKYDLTLTNEGLSTYLLL
FT                   KYEGDESLIPSVLDLKNPGWKDNDPLARGNLPLLTKVLRNSSVIPDANGGLKETKKQKN
FT                   TNWNPRLHFVWSVLLPLFGNGKLENTSHISKKRKKTNNKKVQNSIQFPEFWKMAVDESF
FT                   FNEKASSERKYLGFLIIDAAFKAVPGSYIGFCFSQNVMRTLINQSIDSQRVLNKISQLT
FT                   LDSIVKACEEDSANRLVPCLNAMLFGPHGSINFDKLTKSGTVSKLIAIKELPSTVLAQL
FT                   LDVFFLQLQDKKGVLSHTLFALDSILHIVRAHKVEINDMDIMKPVLRPIVYMAFFKHTS
FT                   DDLKLEQLHELAKERLYSILGELTINKEIRCKDPEINSWQYLTLKLILDIENSHVGDLI
FT                   NPLDENLENIKNEAISCLSKVCRSRTAQSWGLSTLLSMCLVQLYAGDTDSISVIEELCE
FT                   FSKHENNSMVGITEILLSLLAQKKALLRKLSLIIWQQFIEEVGLEELQILLDILKAREN
FT                   KQGFAQLFEGEEEFEEIKEENDASEDESKTGSESESESESDSDDADEKDEEDEANEDIL
FT                   NIDKEATSALVKALNLPDNIVNDKGEVDLDQLEGLSDDGGDDEDEESMDDEKMMELDDQ
FT                   LSEIFKRRKEALSSISTGNQRKFEVKQSRENVISFKHRVVDMLAVYVKYCEKLTLANKS
FT                   EHSNNLGGSLSKLVYFIIPMLKCVNETLDRPLADKISKLLKGKIFKIKVTAFKDMNKDI
FT                   ELMDLLKKTHKLMLTSKPGQHAAVFYSMCSTSSLFLSKLYVEIGGNDKLDELIDLYTAT
FT                   TKEWMQKGKCGPNIFIDFINWLSSKKQTVMDKE"
FT   gene            complement(52150..52320)
FT                   /locus_tag="snR80"
FT   ncRNA           complement(52150..52320)
FT                   /locus_tag="snR80"
FT                   /product="SNR80"
FT                   /note="H/ACA box small nucleolar RNA (snoRNA); guides
FT                   pseudouridylation of large subunit (LSU) rRNA at position
FT                   U776 and small subunit (SSU) rRNA at position U759"
FT                   /experiment="EXISTENCE:curator inference:GO:0005730
FT                   nucleolus [PMID:15306656]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030559 rRNA
FT                   pseudouridylation guide activity
FT                   [PMID:15306656|PMID:15923376]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031118 rRNA
FT                   pseudouridine synthesis [PMID:15306656|PMID:15923376]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031429 box
FT                   H/ACA snoRNP complex [PMID:15923376]"
FT                   /ncRNA_class="snoRNA"
FT   gene            complement(52721..53218)
FT                   /gene="RPL12A"
FT                   /locus_tag="YEL054C"
FT   mRNA            complement(52721..53218)
FT                   /gene="RPL12A"
FT                   /locus_tag="YEL054C"
FT                   /product="ribosomal 60S subunit protein L12A"
FT   CDS_pept        complement(52721..53218)
FT                   /codon_start=1
FT                   /gene="RPL12A"
FT                   /locus_tag="YEL054C"
FT                   /product="ribosomal 60S subunit protein L12A"
FT                   /note="Ribosomal 60S subunit protein L12A; rpl12a rpl12b
FT                   double mutant exhibits slow growth and slow translation;
FT                   homologous to mammalian ribosomal protein L12 and bacterial
FT                   L11; RPL12A has a paralog, RPL12B, that arose from the
FT                   whole genome duplication"
FT                   /db_xref="GOA:P0CX53"
FT                   /db_xref="InterPro:IPR000911"
FT                   /db_xref="InterPro:IPR020783"
FT                   /db_xref="InterPro:IPR020784"
FT                   /db_xref="InterPro:IPR020785"
FT                   /db_xref="InterPro:IPR036769"
FT                   /db_xref="InterPro:IPR036796"
FT                   /db_xref="PDB:1K5Y"
FT                   /db_xref="PDB:3J16"
FT                   /db_xref="PDB:3J77"
FT                   /db_xref="PDB:3J78"
FT                   /db_xref="PDB:4V4B"
FT                   /db_xref="PDB:4V6I"
FT                   /db_xref="PDB:4V7F"
FT                   /db_xref="PDB:4V7R"
FT                   /db_xref="PDB:5DGE"
FT                   /db_xref="PDB:5FL8"
FT                   /db_xref="PDB:5JCS"
FT                   /db_xref="PDB:5JUO"
FT                   /db_xref="PDB:5JUP"
FT                   /db_xref="PDB:5JUS"
FT                   /db_xref="PDB:5JUT"
FT                   /db_xref="PDB:5JUU"
FT                   /db_xref="PDB:6GQ1"
FT                   /db_xref="PDB:6GQB"
FT                   /db_xref="PDB:6GQV"
FT                   /db_xref="PDB:6N8J"
FT                   /db_xref="PDB:6N8M"
FT                   /db_xref="PDB:6N8N"
FT                   /db_xref="PDB:6N8O"
FT                   /db_xref="PDB:6R84"
FT                   /db_xref="PDB:6R87"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CX53"
FT                   /experiment="EXISTENCE:curator inference:GO:0002181
FT                   cytoplasmic translation [PMID:11983894]"
FT                   /experiment="EXISTENCE:curator inference:GO:0003735
FT                   structural constituent of ribosome [PMID:11983894]"
FT                   /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic
FT                   large ribosomal subunit [PMID:11983894]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000027
FT                   ribosomal large subunit assembly [PMID:9822666]"
FT                   /protein_id="DAA07600.1"
FT                   /translation="MPPKFDPNEVKYLYLRAVGGEVGASAALAPKIGPLGLSPKKVGED
FT                   IAKATKEFKGIKVTVQLKIQNRQAAASVVPSASSLVITALKEPPRDRKKDKNVKHSGNI
FT                   QLDEIIEIARQMRDKSFGRTLASVTKEILGTAQSVGCRVDFKNPHDIIEGINAGEIEIP
FT                   EN"
FT   gene            complement(53901..56102)
FT                   /gene="MAK10"
FT                   /gene_synonym="NAA35"
FT                   /locus_tag="YEL053C"
FT   mRNA            complement(53901..56102)
FT                   /gene="MAK10"
FT                   /gene_synonym="NAA35"
FT                   /locus_tag="YEL053C"
FT                   /product="Mak10p"
FT   CDS_pept        complement(53901..56102)
FT                   /codon_start=1
FT                   /gene="MAK10"
FT                   /gene_synonym="NAA35"
FT                   /locus_tag="YEL053C"
FT                   /product="Mak10p"
FT                   /note="Non-catalytic subunit of the NatC N-terminal
FT                   acetyltransferase; required for replication of dsRNA virus;
FT                   expression is glucose-repressible; human NatC ortholog,
FT                   Naa35, requires co-expression of the human catalytic
FT                   subunit, Naa30, to functionally complement the null allele"
FT                   /db_xref="GOA:Q02197"
FT                   /db_xref="InterPro:IPR007244"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q02197"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031417 NatC complex
FT                   [PMID:10504710]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004596 peptide
FT                   alpha-N-acetyltransferase activity [PMID:11274203]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006474
FT                   N-terminal protein amino acid acetylation [PMID:11274203]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016236
FT                   macroautophagy [PMID:19793921]"
FT                   /protein_id="DAA07601.1"
FT                   /translation="MEVDSILGSLSITDDFDQLVDVTSLFDELCSKLKPEAIVKDPRFD
FT                   LFEGTHSLEVNNSKLDSSLIELTAEEIEFDVNVAYDPPLASVAAIADRLLRCVISWLND
FT                   YQTLPTTVLSCRYTESLLSSLVKGTTAGSSWCTGNILYDKVLGSCILGVCYLTKFVQKL
FT                   LSAGIVFEEEDLNFNNMGFNTFDNLPGQDVVINSLTESLQILEAYSDDSLHLTMLKHIL
FT                   KIIICLVHLEDHLTDYSTKTSHLDELIENANSVNGIFPQLQLSPPKGAFSTYIQKHRSN
FT                   QFPPRKITKLPTDYSGFITLANDVKTILLVDKAESALETYQFAKFFNKLEQRHVIARIL
FT                   FPLFFIRDDRTVLGKFSYTQFYLLHVKEFSAQTPSEFESSIGNELIQESSNMLLEWYQN
FT                   CSQNTCRYRQGFNRQLILWDSLQAQFESVNSQVYCSWTYFMKLSSMIEFSLKGFDLDIY
FT                   KPFEAYSMFWYVYYLSHHLETFLKDSQNDIESNINAIHSMNKKLKKLKAGEKKDQLRLK
FT                   YRFAMDNEMEQLQATKQFLNYLLKEINITKSLCLIEVFQFAILKSFGLIDNKNSTPSKF
FT                   SNERLIHNLRFKPFNSIGVPELPEYEVFQQTLKDFVIEEKGAAFDIKLERATNFIETEV
FT                   RNVVSSIDEIMQGIKGGDNNGVLVTGTRLVQELSLEYYCKLKHTSKALSVNSKVIVNTL
FT                   KKNIKNKDSHEYKVELVHTTEGWNYFPIQTLRIKQDRYK"
FT   gene            56571..58100
FT                   /gene="AFG1"
FT                   /locus_tag="YEL052W"
FT   mRNA            56571..58100
FT                   /gene="AFG1"
FT                   /locus_tag="YEL052W"
FT                   /product="Afg1p"
FT   CDS_pept        56571..58100
FT                   /codon_start=1
FT                   /gene="AFG1"
FT                   /locus_tag="YEL052W"
FT                   /product="Afg1p"
FT                   /note="Protein that may act as a chaperone for cytochrome c
FT                   oxidase subunits; conserved protein; may act as a chaperone
FT                   in the degradation of misfolded or unassembled cytochrome c
FT                   oxidase subunits; localized to matrix face of the
FT                   mitochondrial inner membrane; member of the AAA family but
FT                   lacks a protease domain"
FT                   /db_xref="GOA:P32317"
FT                   /db_xref="InterPro:IPR005654"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32317"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion
FT                   [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005743
FT                   mitochondrial inner membrane [PMID:17430883]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006515 protein
FT                   quality control for misfolded or incompletely synthesized
FT                   proteins [PMID:17430883]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein
FT                   import into peroxisome matrix [PMID:19118449]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular
FT                   response to oxidative stress [PMID:17430883]"
FT                   /protein_id="DAA07602.1"
FT                   /translation="MIALKPNAVRTFRQVQHCSFRICRYQSTKSNKCLTPLQEYDRLVK
FT                   LGKLRDDTYQRGIISSLGDLYDSLVKYVPPVVKTPNAVDQVGGWLNGLKSVFSRGKPKN
FT                   IGAYVDVSKIGNSIPRGVYLYGDVGCGKTMLMDLFYTTIPNHLTKKRIHFHQFMQYVHK
FT                   RSHEIVREQNLKELGDAKGKEIDTVPFLAAEIANNSHVLCFDEFQVTDVADAMILRRLM
FT                   TALLSDDYGVVLFATSNRHPDELYINGVQRQSFIPCIELIKHRTKVIFLNSPTDYRKIP
FT                   RPVSSVYYFPSDTSIKYASKECKTRRETHIKEWYNYFAQASHTDDSTDSHTVHKTFYDY
FT                   PLTIWGREFKVPKCTPPRVAQFTFKQLCGEPLAAGDYLTLAKNFEAFIVTDIPYLSIYV
FT                   RDEVRRFITFLDAVYDSGGKLATTGAADFSSLFVEPEQILNDFELRPTTKEPDSVDTGM
FT                   VDEMVEKHGFSKEIAKKSQMFALDEERFAFARALSRLSQMSSTDWVTKPTY"
FT   gene            58378..59148
FT                   /gene="VMA8"
FT                   /locus_tag="YEL051W"
FT   mRNA            58378..59148
FT                   /gene="VMA8"
FT                   /locus_tag="YEL051W"
FT                   /product="H(+)-transporting V1 sector ATPase subunit D"
FT   CDS_pept        58378..59148
FT                   /codon_start=1
FT                   /gene="VMA8"
FT                   /locus_tag="YEL051W"
FT                   /product="H(+)-transporting V1 sector ATPase subunit D"
FT                   /note="Subunit D of the V1 peripheral membrane domain of
FT                   V-ATPase; part of the electrogenic proton pump found
FT                   throughout the endomembrane system; plays a role in the
FT                   coupling of proton transport and ATP hydrolysis; the V1
FT                   peripheral membrane domain of the vacuolar H+-ATPase
FT                   (V-ATPase) has eight subunits"
FT                   /db_xref="GOA:P32610"
FT                   /db_xref="InterPro:IPR002699"
FT                   /db_xref="PDB:3J9T"
FT                   /db_xref="PDB:3J9U"
FT                   /db_xref="PDB:3J9V"
FT                   /db_xref="PDB:4RND"
FT                   /db_xref="PDB:5BW9"
FT                   /db_xref="PDB:5D80"
FT                   /db_xref="PDB:5VOX"
FT                   /db_xref="PDB:5VOY"
FT                   /db_xref="PDB:5VOZ"
FT                   /db_xref="PDB:6O7V"
FT                   /db_xref="PDB:6O7W"
FT                   /db_xref="PDB:6O7X"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32610"
FT                   /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
FT                   vacuole membrane [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016471 vacuolar
FT                   proton-transporting V-type ATPase complex [PMID:10801866]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar
FT                   acidification [PMID:29519938]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0046961
FT                   proton-transporting ATPase activity, rotational mechanism
FT                   [PMID:10801866]"
FT                   /protein_id="DAA07603.1"
FT                   /translation="MSGNREQVFPTRMTLGLMKTKLKGANQGYSLLKRKSEALTKRFRD
FT                   ITKRIDDAKQKMGRVMQTAAFSLAEVSYATGENIGYQVQESVSTARFKVRARQENVSGV
FT                   YLSQFESYIDPEINDFRLTGLGRGGQQVQRAKEIYSRAVETLVELASLQTAFIILDEVI
FT                   KVTNRRVNAIEHVIIPRTENTIAYINSELDELDREEFYRLKKVQEKKQNETAKLDAEMK
FT                   LKRDRAEQDASEVAADEEPQGETLVADQEDDVIF"
FT   rep_origin      59338..59477
FT                   /note="ARS507; Autonomously Replicating Sequence"
FT   gene            complement(59670..60851)
FT                   /gene="RML2"
FT                   /gene_synonym="uL2m"
FT                   /locus_tag="YEL050C"
FT   mRNA            complement(59670..60851)
FT                   /gene="RML2"
FT                   /gene_synonym="uL2m"
FT                   /locus_tag="YEL050C"
FT                   /product="mitochondrial 54S ribosomal protein RML2"
FT   CDS_pept        complement(59670..60851)
FT                   /codon_start=1
FT                   /gene="RML2"
FT                   /gene_synonym="uL2m"
FT                   /locus_tag="YEL050C"
FT                   /product="mitochondrial 54S ribosomal protein RML2"
FT                   /note="Mitochondrial ribosomal protein of the large subunit
FT                   (L2); has similarity to E. coli L2 ribosomal protein;
FT                   mutant allele (fat21) causes inability to utilize oleate,
FT                   and induce oleic acid oxidation; may interfere with
FT                   activity of the Adr1p transcription factor"
FT                   /db_xref="GOA:P32611"
FT                   /db_xref="InterPro:IPR002171"
FT                   /db_xref="InterPro:IPR005880"
FT                   /db_xref="InterPro:IPR008991"
FT                   /db_xref="InterPro:IPR012340"
FT                   /db_xref="InterPro:IPR014722"
FT                   /db_xref="InterPro:IPR014726"
FT                   /db_xref="InterPro:IPR022666"
FT                   /db_xref="InterPro:IPR022669"
FT                   /db_xref="InterPro:IPR022671"
FT                   /db_xref="PDB:3J6B"
FT                   /db_xref="PDB:5MRC"
FT                   /db_xref="PDB:5MRE"
FT                   /db_xref="PDB:5MRF"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32611"
FT                   /experiment="EXISTENCE:direct assay:GO:0003735 structural
FT                   constituent of ribosome [PMID:9445368]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005762
FT                   mitochondrial large ribosomal subunit [PMID:9445368]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032543
FT                   mitochondrial translation [PMID:9079633]"
FT                   /protein_id="DAA07604.1"
FT                   /translation="MLVLGSLRSALSCSSTASLISKRNPCYPYGILCRTLSQSVKLWQE
FT                   NTSKDDSSLNITPRLLKIIPNDTDIVTLEKQDELIKRRRKLSKEVTQMKRLKPVSPGLR
FT                   WYRSPIYPYLYKGRPVRALTVVRKKHGGRNNSGKITVRHQGGGHRNRTRLIDFNRWEGG
FT                   AQTVQRIEYDPGRSSHIALLKHNTTGELSYIIACDGLRPGDVVESFRRGIPQTLLNEMG
FT                   GKVDPAILSVKTTQRGNCLPISMIPIGTIIHNVGITPVGPGKFCRSAGTYARVLAKLPE
FT                   KKKAIVRLQSGEHRYVSLEAVATIGVVSNIDHQNRSLGKAGRSRWLGIRPTVRGVAMNK
FT                   CDHPHGGGRGKSKSNKLSMSPWGQLAKGYKTRRGKNQNRMKVKDRPRGKDARL"
FT   gene            61352..61433
FT                   /locus_tag="snR67"
FT   ncRNA           61352..61433
FT                   /locus_tag="snR67"
FT                   /product="SNR67"
FT                   /note="C/D box small nucleolar RNA (snoRNA); guides
FT                   2'-O-methylation of large subunit (LSU) rRNA at positions
FT                   G2619 and U2724"
FT                   /experiment="EXISTENCE:curator inference:GO:0005730
FT                   nucleolus [PMID:10024243]"
FT                   /experiment="EXISTENCE:curator inference:GO:0031428 box C/D
FT                   snoRNP complex [PMID:10024243]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
FT                   2'-O-ribose methylation guide activity [PMID:10024243]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
FT                   methylation [PMID:10024243]"
FT                   /ncRNA_class="snoRNA"
FT   gene            61699..61789
FT                   /locus_tag="snR53"
FT   ncRNA           61699..61789
FT                   /locus_tag="snR53"
FT                   /product="SNR53"
FT                   /note="C/D box small nucleolar RNA (snoRNA); guides
FT                   2'-O-methylation of small subunit (SSU) rRNA at position
FT                   A796"
FT                   /experiment="EXISTENCE:curator inference:GO:0005730
FT                   nucleolus [PMID:10024243]"
FT                   /experiment="EXISTENCE:curator inference:GO:0031428 box C/D
FT                   snoRNP complex [PMID:10024243]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
FT                   2'-O-ribose methylation guide activity [PMID:10024243]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
FT                   methylation [PMID:10024243]"
FT                   /ncRNA_class="snoRNA"
FT   gene            complement(61890..61960)
FT                   /locus_tag="tG(GCC)E"
FT   tRNA            complement(61890..61960)
FT                   /locus_tag="tG(GCC)E"
FT                   /product="tRNA-Gly"
FT                   /note="tG(GCC)E; Glycine tRNA (tRNA-Gly), predicted by
FT                   tRNAscan-SE analysis"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030371 translation
FT                   repressor activity [PMID:27609601]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043022 ribosome
FT                   binding [PMID:27609601]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043555 regulation
FT                   of translation in response to stress [PMID:27609601]"
FT   repeat_region   62081..62756
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   repeat_region   62142..62474
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            63728..64090
FT                   /gene="PAU2"
FT                   /locus_tag="YEL049W"
FT   mRNA            63728..64090
FT                   /gene="PAU2"
FT                   /locus_tag="YEL049W"
FT                   /product="seripauperin PAU2"
FT   CDS_pept        63728..64090
FT                   /codon_start=1
FT                   /gene="PAU2"
FT                   /locus_tag="YEL049W"
FT                   /product="seripauperin PAU2"
FT                   /note="Member of the seripauperin multigene family; encoded
FT                   mainly in subtelomeric region; active during alcoholic
FT                   fermentation; regulated by anaerobiosis; negatively
FT                   regulated by oxygen; repressed by heme"
FT                   /db_xref="GOA:P32612"
FT                   /db_xref="InterPro:IPR000992"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32612"
FT                   /protein_id="DAA07605.1"
FT                   /translation="MVKLTSIAAGVAAIAATASATTTLAQSDERVNLVELGVYVSDIRA
FT                   HLAQYYSFQAAHPTETYPIEVAEAVFNYGDFTTMLTGIAPDQVTRMITGVPWYSSRLKP
FT                   AISSALSKDGIYTIAN"
FT   gene            complement(64709..65167)
FT                   /gene="TCA17"
FT                   /locus_tag="YEL048C"
FT   mRNA            complement(64709..65167)
FT                   /gene="TCA17"
FT                   /locus_tag="YEL048C"
FT                   /product="Tca17p"
FT   CDS_pept        complement(64709..65167)
FT                   /codon_start=1
FT                   /gene="TCA17"
FT                   /locus_tag="YEL048C"
FT                   /product="Tca17p"
FT                   /note="Component of transport protein particle (TRAPP)
FT                   complex II; TRAPPII is a multimeric guanine
FT                   nucleotide-exchange factor for the GTPase Ypt1p, regulating
FT                   intra-Golgi and endosome-Golgi traffic; promotes
FT                   association of TRAPPII-specific subunits with the TRAPP
FT                   core complex; sedlin related; human Sedlin mutations cause
FT                   SEDT, a skeletal disorder"
FT                   /db_xref="GOA:P32613"
FT                   /db_xref="InterPro:IPR006722"
FT                   /db_xref="InterPro:IPR011012"
FT                   /db_xref="PDB:3PR6"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32613"
FT                   /experiment="EXISTENCE:direct assay:GO:0005794 Golgi
FT                   apparatus [PMID:19220810]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030136
FT                   clathrin-coated vesicle [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII
FT                   protein complex [PMID:21453443]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034498 early
FT                   endosome to Golgi transport [PMID:19220810]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034622 cellular
FT                   protein-containing complex assembly [PMID:21453443]"
FT                   /protein_id="DAA07606.1"
FT                   /translation="MSLRPCFVSLIDESDKPILIYVPNEAENEMNDVLKYNVLSNISLD
FT                   YFESALVEWHSLDSKPLLKSIFQLEGVSVFAMLIKQTGLKIVIGFEQKSLSGADDEFEA
FT                   INQIFETVRKIYIRVKCNPLLVSGDEKSIIKSLERKFDELFISTEVEL"
FT   gene            complement(65385..66797)
FT                   /gene="FRD1"
FT                   /locus_tag="YEL047C"
FT   mRNA            complement(65385..66797)
FT                   /gene="FRD1"
FT                   /locus_tag="YEL047C"
FT                   /product="fumarate reductase"
FT   CDS_pept        complement(65385..66797)
FT                   /codon_start=1
FT                   /gene="FRD1"
FT                   /locus_tag="YEL047C"
FT                   /product="fumarate reductase"
FT                   /EC_number="1.3.1.6"
FT                   /note="Soluble fumarate reductase; required with isoenzyme
FT                   Osm1p for anaerobic growth; may interact with ribosomes,
FT                   based on co-purification experiments; authentic, non-tagged
FT                   protein is detected in purified mitochondria in
FT                   high-throughput studies; similar to Arxula adeninovorans
FT                   fumarate reductase; protein abundance increases in response
FT                   to DNA replication stress; FRD1 has a paralog, OSM1, that
FT                   arose from the whole genome duplication"
FT                   /db_xref="GOA:P32614"
FT                   /db_xref="InterPro:IPR003953"
FT                   /db_xref="InterPro:IPR010960"
FT                   /db_xref="InterPro:IPR027477"
FT                   /db_xref="InterPro:IPR036188"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32614"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:9587404]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:16622836]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016156 fumarate
FT                   reductase (NADH) activity [PMID:8946166]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0071454
FT                   cellular response to anoxia [PMID:17345583|PMID:9711846]"
FT                   /protein_id="DAA07607.1"
FT                   /translation="MSLSPVVVIGTGLAGLAAANELVNKYNIPVTILEKASSIGGNSIK
FT                   ASSGINGACTETQRHFHIEDSPRLFEDDTIKSAKGKGVQELMAKLANDSPLAIEWLKNE
FT                   FDLKLDLLAQLGGHSVARTHRSSGKLPPGFEIVSALSNNLKKLAETKPELVKINLDSKV
FT                   VDIHEKDGSISAVVYEDKNGEKHMVSANDVVFCSGGFGFSKEMLKEYAPELVNLPTTNG
FT                   QQTTGDGQRLLQKLGADLIDMDQIQVHPTGFIDPNDRSSSWKFLAAESLRGLGGILLNP
FT                   ITGRRFVNELTTRDVVTAAIQKVCPQEDNRALLVMGEKMYTDLKNNLDFYMFKKLVQKL
FT                   TLSQVVSEYNLPITVAQLCEELQTYSSFTTKADPLGRTVILNEFGSDVTPETVVFIGEV
FT                   TPVVHFTMGGARINVKAQVIGKNDERLLKGLYAAGEVSGGVHGANRLGGSSLLECVVFG
FT                   RTAAESIANDRK"
FT   gene            complement(67629..68792)
FT                   /gene="GLY1"
FT                   /locus_tag="YEL046C"
FT   mRNA            complement(67629..68792)
FT                   /gene="GLY1"
FT                   /locus_tag="YEL046C"
FT                   /product="threonine aldolase GLY1"
FT   CDS_pept        complement(67629..68792)
FT                   /codon_start=1
FT                   /gene="GLY1"
FT                   /locus_tag="YEL046C"
FT                   /product="threonine aldolase GLY1"
FT                   /EC_number="4.1.2.48"
FT                   /note="Threonine aldolase; catalyzes the cleavage of
FT                   L-allo-threonine and L-threonine to glycine; involved in
FT                   glycine biosynthesis"
FT                   /db_xref="GOA:P37303"
FT                   /db_xref="InterPro:IPR001597"
FT                   /db_xref="InterPro:IPR015421"
FT                   /db_xref="InterPro:IPR015424"
FT                   /db_xref="InterPro:IPR023603"
FT                   /db_xref="UniProtKB/Swiss-Prot:P37303"
FT                   /experiment="EXISTENCE:direct assay:GO:0004793 threonine
FT                   aldolase activity [PMID:9163906]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:12676688]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006545 glycine
FT                   biosynthetic process [PMID:3086094]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006567 threonine
FT                   catabolic process [PMID:3086094]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008732
FT                   L-allo-threonine aldolase activity [PMID:9151955]"
FT                   /protein_id="DAA07608.1"
FT                   /translation="MTEFELPPKYITAANDLRSDTFTTPTAEMMEAALEASIGDAVYGE
FT                   DVDTVRLEQTVARMAGKEAGLFCVSGTLSNQIAIRTHLMQPPYSILCDYRAHVYTHEAA
FT                   GLAILSQAMVVPVVPSNGDYLTLEDIKSHYVPDDGDIHGAPTRLISLENTLHGIVYPLE
FT                   ELVRIKAWCMENGLKLHCDGARIWNAAAQSGVPLKQYGEIFDSISICLSKSMGAPIGSV
FT                   LVGNLKFVKKATHFRKQQGGGIRQSGMMARMALVNINNDWKSQLLYSHSLAHELAEYCE
FT                   AKGIPLESPADTNFVFINLKAARMDPDVLVKKGLKYNVKLMGGRVSFHYQVTRDTLEKV
FT                   KLAISEAFDYAKEHPFDCNGPTQIYRSESTEVDVDGNAIREIKTYKY"
FT   gene            69757..70257
FT                   /gene="IES6"
FT                   /locus_tag="YEL044W"
FT   mRNA            69757..70257
FT                   /gene="IES6"
FT                   /locus_tag="YEL044W"
FT                   /product="Ies6p"
FT   CDS_pept        69757..70257
FT                   /codon_start=1
FT                   /gene="IES6"
FT                   /locus_tag="YEL044W"
FT                   /product="Ies6p"
FT                   /note="Component of the INO80 chromatin remodeling complex;
FT                   critical for INO80 function; involved in regulation of
FT                   chromosome segregation and maintenance of normal
FT                   centromeric chromatin structure; human ortholog INO80C is a
FT                   member of the human INO80 complex; implicated in DNA repair
FT                   based on genetic interactions with RAD52 epistasis genes"
FT                   /db_xref="GOA:P32617"
FT                   /db_xref="InterPro:IPR013272"
FT                   /db_xref="InterPro:IPR029525"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32617"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006338
FT                   chromatin remodeling [PMID:23207916]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051983
FT                   regulation of chromosome segregation [PMID:23207916]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031011
FT                   Ino80 complex [PMID:24034245]"
FT                   /protein_id="DAA07609.1"
FT                   /translation="MSGSRGNSSNSSVSNNSNNNNNNDGGDERLLFLRSVGERNEIGFP
FT                   SRFKSAHYKKPTRRHKSARQLISDENKRINALLTKANKAAESSTAARRLVPKATYFSVE
FT                   APPSIRPAKKYCDVTGLKGFYKSPTNNIRYHNAEIYQLIVKPMAPGVDQEYLKLRGANF
FT                   VLK"
FT   gene            70478..73348
FT                   /locus_tag="YEL043W"
FT   mRNA            70478..73348
FT                   /locus_tag="YEL043W"
FT                   /product="hypothetical protein"
FT   CDS_pept        70478..73348
FT                   /codon_start=1
FT                   /locus_tag="YEL043W"
FT                   /product="hypothetical protein"
FT                   /note="Predicted cytoskeleton protein involved in
FT                   intracellular signaling; based on quantitative analysis of
FT                   protein-protein interaction maps; may interact with
FT                   ribosomes, based on co-purification studies; contains
FT                   fibronectin type III domain fold"
FT                   /db_xref="GOA:P32618"
FT                   /db_xref="InterPro:IPR003961"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="InterPro:IPR036116"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32618"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:26928762]"
FT                   /protein_id="DAA07610.1"
FT                   /translation="MPVSVITTVLACLWLSYRLYKFLTIPVSSIVSTLKIKTPPATKVS
FT                   IDKIATDSVTIHWENEPVKAEDNGSADRNFISHYLLYLNNTQLAIFPNNPNSLYTCCSI
FT                   TGLEAETQYQLDFITINNKGFINKLPSIYCMTKAREANEALKTRKWRRNTITSSTAMQP
FT                   RNSKSEPAPLPSHYSSVSLSTFSSNITNSATSNNGSNLPAYTSLTTLKDLDSFSIDDLK
FT                   KILICAQEDLHDVLSQQTSLLQDFQESKLELELELDNLKTHWSHEIDLRKSLKSNIKSL
FT                   ENSKLLTDLKIEKLNKKIDKSKEKISKMRNDMQKWSQEDTELLSKDTIKEKYFKLLNES
FT                   NASVANINKEIESLQNEISKMEESNKRLNASKKSLITSIVVNANVENDKPIASGELSAV
FT                   LKKLNDFTLEKNGFLSNAGEEFLSKLNADSSLIKMIKQELSIDQELEANWKLQRSNLLK
FT                   KISALENQFNEMSLNNRNLKTKLMVQPYKNNGDSLAATNSNNSAEKNRSSGSIQLPLSN
FT                   NMSRTGSIDLISNNNKSINNSNADSAPPLRLHNPVSYSPSNEPIQPSSSLLSQLTQDTD
FT                   NRSMLSNHISSNNENKQQPSSYSHALPTTATANATATATATNGHSRSNLWTTAQFAQPS
FT                   HQQVSTELDQAFEYDNANHLISGLQNMIYDETDYPDNISNYSKGFTTDELDNYWTKQQP
FT                   QVRSTNESLFSTTGTPMSSYKANPVISPYSSSHLRQTSNATNTNPMHPQSLLAATLNDP
FT                   SLQSFVRSGSFYSAPQPANSLQNNINGNETENISPRISSDFNLLVPNLSPRLSNDVPIV
FT                   PGNNTTLTPSHSNILTMNHQPTADNITRRSFHASSPPFNSIWNSNTNQLSPPLEEQYHL
FT                   DVPVGPKVPAKEPSPKPSHKRNQSNSSISSAWSKFKHKSASSPANADTDIQDSSTPSTS
FT                   PSGRRMSKLLSKSGMNNLFNPHSHDS"
FT   gene            73771..75327
FT                   /gene="GDA1"
FT                   /locus_tag="YEL042W"
FT   mRNA            73771..75327
FT                   /gene="GDA1"
FT                   /locus_tag="YEL042W"
FT                   /product="guanosine diphosphatase"
FT   CDS_pept        73771..75327
FT                   /codon_start=1
FT                   /gene="GDA1"
FT                   /locus_tag="YEL042W"
FT                   /product="guanosine diphosphatase"
FT                   /EC_number="3.6.1.42"
FT                   /note="Guanosine diphosphatase located in the Golgi;
FT                   involved in the transport of GDP-mannose into the Golgi
FT                   lumen, converting GDP to GMP after mannose is transferred
FT                   to substrates; null mutants are defective in sporulation
FT                   and pre-meiotic S phase entry; orthologous to human ENTPD6,
FT                   a meiosis-associated non-obstructive azoospermia (NOA)
FT                   related gene identified in GWAS studies"
FT                   /db_xref="GOA:P32621"
FT                   /db_xref="InterPro:IPR000407"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32621"
FT                   /experiment="EXISTENCE:direct assay:GO:0004382
FT                   guanosine-diphosphatase activity [PMID:7506254]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005794 Golgi
FT                   apparatus [PMID:9614179]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045134
FT                   uridine-diphosphatase activity [PMID:11425802]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein
FT                   glycosylation [PMID:8391537]"
FT                   /protein_id="DAA07611.1"
FT                   /translation="MAPIFRNYRFAIGAFAVIMLILLIKTSSIGPPSIARTVTPNASIP
FT                   KTPEDISILPVNDEPGYLQDSKTEQNYPELADAVKSQTSQTCSEEHKYVIMIDAGSTGS
FT                   RVHIYKFDVCTSPPTLLDEKFDMLEPGLSSFDTDSVGAANSLDPLLKVAMNYVPIKARS
FT                   CTPVAVKATAGLRLLGDAKSSKILSAVRDHLEKDYPFPVVEGDGVSIMGGDEEGVFAWI
FT                   TTNYLLGNIGANGPKLPTAAVFDLGGGSTQIVFEPTFPINEKMVDGEHKFDLKFGDENY
FT                   TLYQFSHLGYGLKEGRNKVNSVLVENALKDGKILKGDNTKTHQLSSPCLPPKVNATNEK
FT                   VTLESKETYTIDFIGPDEPSGAQCRFLTDEILNKDAQCQSPPCSFNGVHQPSLVRTFKE
FT                   SNDIYIFSYFYDRTRPLGMPLSFTLNELNDLARIVCKGEETWNSVFSGIAGSLDELESD
FT                   SHFCLDLSFQVSLLHTGYDIPLQRELRTGKKIANKEIGWCLGASLPLLKADNWKCKIQS
FT                   A"
FT   gene            75944..77431
FT                   /gene="YEF1"
FT                   /locus_tag="YEL041W"
FT   mRNA            75944..77431
FT                   /gene="YEF1"
FT                   /locus_tag="YEL041W"
FT                   /product="NADH/NAD(+) kinase"
FT   CDS_pept        75944..77431
FT                   /codon_start=1
FT                   /gene="YEF1"
FT                   /locus_tag="YEL041W"
FT                   /product="NADH/NAD(+) kinase"
FT                   /EC_number="2.7.1.86"
FT                   /note="ATP-NADH kinase; phosphorylates both NAD and NADH;
FT                   homooctameric structure consisting of 60-kDa subunits;
FT                   similar to Pos5p; overexpression complements certain pos5
FT                   phenotypes; YEF1 has a paralog, UTR1, that arose from the
FT                   whole genome duplication"
FT                   /db_xref="GOA:P32622"
FT                   /db_xref="InterPro:IPR002504"
FT                   /db_xref="InterPro:IPR016064"
FT                   /db_xref="InterPro:IPR017437"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32622"
FT                   /experiment="EXISTENCE:direct assay:GO:0003951 NAD+ kinase
FT                   activity [PMID:15978040]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006741 NADP
FT                   biosynthetic process [PMID:15978040]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042736 NADH kinase
FT                   activity [PMID:15978040]"
FT                   /protein_id="DAA07612.1"
FT                   /translation="MKTDRLLINASPETCTKGDAEMDTMDTIDRMTSVKVLAEGKVLSN
FT                   FEEPGLMRCGYHDAKNWVRRLSSETIVGEDTSNLYPFYVDTAYDVRRLRKDLINAKVDL
FT                   QVENLIIICNINDISTVFLMREVVEWILRNFHSITVYVQDIFKKSTQFAVGDLCKDSNC
FT                   SKNRVKYWSKEFVKKHDSFFDLMITLGGDGTVLFASSIFTKDVPPIVPFALGSLGFLTN
FT                   FEFQNFKETLKHILTDEVRINLRMRLQCKLYRRNKPEIDAATGRKICYIDFISEHHVLN
FT                   EVTIDRGPAPCLSLLELYGNDSLMTKVQGDGLIVATPTGSTAYSLSAGGSLISPSVNAI
FT                   AVTPICPHTLSFRPIILPDSMELKVRVDMNSRGTSWVNFDGKDRVELKQGDYVVITASP
FT                   YSVPTIESSASEFFESISKNLNWNDREEQKPFAHILSPKNQEKYRLDSSKNGNDTISNP
FT                   LESSCISSDAQDEERKSVTETETEIVVERTRQAHFAI"
FT   gene            78053..79456
FT                   /gene="UTR2"
FT                   /gene_synonym="CRH2"
FT                   /locus_tag="YEL040W"
FT   mRNA            78053..79456
FT                   /gene="UTR2"
FT                   /gene_synonym="CRH2"
FT                   /locus_tag="YEL040W"
FT                   /product="Utr2p"
FT   CDS_pept        78053..79456
FT                   /codon_start=1
FT                   /gene="UTR2"
FT                   /gene_synonym="CRH2"
FT                   /locus_tag="YEL040W"
FT                   /product="Utr2p"
FT                   /note="Chitin transglycosylase; functions in the transfer
FT                   of chitin to beta(1-6) and beta(1-3) glucans in the cell
FT                   wall; similar to and functionally redundant with Crh1;
FT                   glycosylphosphatidylinositol (GPI)-anchored protein
FT                   localized to bud neck"
FT                   /db_xref="GOA:P32623"
FT                   /db_xref="InterPro:IPR000757"
FT                   /db_xref="InterPro:IPR013320"
FT                   /db_xref="InterPro:IPR017168"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32623"
FT                   /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud
FT                   neck septin ring [PMID:12045225]"
FT                   /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type
FT                   cell wall [PMID:10383953|PMID:15781460]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016757 transferase
FT                   activity, transferring glycosyl groups [PMID:23919454]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006037 cell
FT                   wall chitin metabolic process [PMID:18694928]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0016757
FT                   transferase activity, transferring glycosyl groups
FT                   [PMID:18694928]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0031505
FT                   fungal-type cell wall organization [PMID:18694928]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006037 cell
FT                   wall chitin metabolic process [PMID:18694928]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016757
FT                   transferase activity, transferring glycosyl groups
FT                   [PMID:18694928]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031505
FT                   fungal-type cell wall organization [PMID:18694928]"
FT                   /protein_id="DAA07613.1"
FT                   /translation="MAIVNSWLICLVSIFSFVVRVEAATFCNATQACPEDKPCCSQYGE
FT                   CGTGQYCLNNCDVRYSFSHDSCMPVPICKSSSTKFKDYSSKLGNANTFLGNVSEADWLY
FT                   TGDVLDYDDEESLILAMPKNSGGTVLSSTRAVWYGKVSARIKTSHLAGVVTGFILYSGA
FT                   GDELDYEFVGADLETAQTNFYWESVLNYTNSANISTTDTFENYHTYELDWHEDYVTWSI
FT                   DGVVGRTLYKNETYNATTQKYQYPQTPSKVDISIWPGGNSTNAPGTIAWSGGEINWDAS
FT                   DISNPGYYYAIVNEVNITCYDPPSDTKKNGTSAYVYTSSSEFLAKDIAITDDEVMMDSD
FT                   EGSGLDPHKGATTSSTQKSSSSTATSSSKTSSDHSSSTKKSSKTSSTASSSSSSSSSSS
FT                   SSSSTATKNGDKVVSSVSSSVTSQTQTTSSVSGSASSSTSSMSGNNAGANVAANWRLTV
FT                   LCVILGYVL"
FT   gene            complement(79636..79977)
FT                   /gene="CYC7"
FT                   /locus_tag="YEL039C"
FT   mRNA            complement(79636..79977)
FT                   /gene="CYC7"
FT                   /locus_tag="YEL039C"
FT                   /product="cytochrome c isoform 2"
FT   CDS_pept        complement(79636..79977)
FT                   /codon_start=1
FT                   /gene="CYC7"
FT                   /locus_tag="YEL039C"
FT                   /product="cytochrome c isoform 2"
FT                   /note="Cytochrome c isoform 2, expressed under hypoxic
FT                   conditions; also known as iso-2-cytochrome c; electron
FT                   carrier of the mitochondrial intermembrane space that
FT                   transfers electrons from ubiquinone-cytochrome c
FT                   oxidoreductase to cytochrome c oxidase during cellular
FT                   respiration; protein abundance increases in response to DNA
FT                   replication stress; CYC7 has a paralog, CYC1, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P00045"
FT                   /db_xref="InterPro:IPR002327"
FT                   /db_xref="InterPro:IPR009056"
FT                   /db_xref="InterPro:IPR036909"
FT                   /db_xref="PDB:1YEA"
FT                   /db_xref="PDB:1YEB"
FT                   /db_xref="PDB:1YTC"
FT                   /db_xref="PDB:3CXH"
FT                   /db_xref="UniProtKB/Swiss-Prot:P00045"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005758
FT                   mitochondrial intermembrane space [PMID:8636074]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006122
FT                   mitochondrial electron transport, ubiquinol to cytochrome c
FT                   [PMID:7814361]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006123
FT                   mitochondrial electron transport, cytochrome c to oxygen
FT                   [PMID:7814361]"
FT                   /experiment="EXISTENCE:direct assay:GO:0009055 electron
FT                   transfer activity [PMID:7814361]"
FT                   /protein_id="DAA07614.1"
FT                   /translation="MAKESTGFKPGSAKKGATLFKTRCQQCHTIEEGGPNKVGPNLHGI
FT                   FGRHSGQVKGYSYTDANINKNVKWDEDSMSEYLTNPKKYIPGTKMAFAGLKKEKDRNDL
FT                   ITYMTKAAK"
FT   gene            80462..81145
FT                   /gene="UTR4"
FT                   /locus_tag="YEL038W"
FT   mRNA            80462..81145
FT                   /gene="UTR4"
FT                   /locus_tag="YEL038W"
FT                   /product="putative acireductone synthase UTR4"
FT   CDS_pept        80462..81145
FT                   /codon_start=1
FT                   /gene="UTR4"
FT                   /locus_tag="YEL038W"
FT                   /product="putative acireductone synthase UTR4"
FT                   /EC_number="3.1.3.77"
FT                   /note="Protein with sequence similarity to acireductone
FT                   synthases; involved in methionine salvage; found in both
FT                   the cytoplasm and nucleus"
FT                   /db_xref="GOA:P32626"
FT                   /db_xref="InterPro:IPR023214"
FT                   /db_xref="InterPro:IPR023943"
FT                   /db_xref="InterPro:IPR027511"
FT                   /db_xref="InterPro:IPR036412"
FT                   /db_xref="PDB:2G80"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32626"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0019509
FT                   L-methionine salvage from methylthioadenosine
FT                   [PMID:18625006]"
FT                   /protein_id="DAA07615.1"
FT                   /translation="MGDNYSTYLLDIEGTVCPISFVKETLFPYFTNKVPQLVQQDTRDS
FT                   PVSNILSQFHIDNKEQLQAHILELVAKDVKDPILKQLQGYVWAHGYESGQIKAPVYADA
FT                   IDFIKRKKRVFIYSSGSVKAQKLLFGYVQDPNAPAHDSLDLNSYIDGYFDINTSGKKTE
FT                   TQSYANILRDIGAKASEVLFLSDNPLELDAAAGVGIATGLASRPGNAPVPDGQKYQVYK
FT                   NFETL"
FT   gene            complement(81407..82603)
FT                   /gene="RAD23"
FT                   /locus_tag="YEL037C"
FT   mRNA            complement(81407..82603)
FT                   /gene="RAD23"
FT                   /locus_tag="YEL037C"
FT                   /product="Rad23p"
FT   CDS_pept        complement(81407..82603)
FT                   /codon_start=1
FT                   /gene="RAD23"
FT                   /locus_tag="YEL037C"
FT                   /product="Rad23p"
FT                   /note="Protein with ubiquitin-like N terminus; subunit of
FT                   Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that
FT                   binds damaged DNA; enhances protein deglycosylation
FT                   activity of Png1p; also involved, with Rad4p, in
FT                   ubiquitylated protein turnover; Rad4p-Rad23p heterodimer
FT                   binds to promoters of DNA damage response genes to repress
FT                   their transcription in the absence of DNA damage"
FT                   /db_xref="GOA:P32628"
FT                   /db_xref="InterPro:IPR000626"
FT                   /db_xref="InterPro:IPR004806"
FT                   /db_xref="InterPro:IPR006636"
FT                   /db_xref="InterPro:IPR009060"
FT                   /db_xref="InterPro:IPR015360"
FT                   /db_xref="InterPro:IPR015940"
FT                   /db_xref="InterPro:IPR029071"
FT                   /db_xref="InterPro:IPR036353"
FT                   /db_xref="PDB:1X3W"
FT                   /db_xref="PDB:1X3Z"
FT                   /db_xref="PDB:2NBU"
FT                   /db_xref="PDB:2NBW"
FT                   /db_xref="PDB:2QSF"
FT                   /db_xref="PDB:2QSG"
FT                   /db_xref="PDB:2QSH"
FT                   /db_xref="PDB:3ESW"
FT                   /db_xref="PDB:3M62"
FT                   /db_xref="PDB:4YIR"
FT                   /db_xref="PDB:6CFI"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32628"
FT                   /experiment="EXISTENCE:direct assay:GO:0000111
FT                   nucleotide-excision repair factor 2 complex [PMID:7768886]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000224
FT                   peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase
FT                   activity [PMID:20016784]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA
FT                   binding [PMID:9813069|PMID:9837874]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006517 protein
FT                   deglycosylation [PMID:20016784]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin
FT                   binding [PMID:11323716]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070628 proteasome
FT                   binding [PMID:25311859|PMID:15117949|PMID:15242647]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:26150418]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030433
FT                   ubiquitin-dependent ERAD pathway [PMID:15167887]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043161
FT                   proteasome-mediated ubiquitin-dependent protein catabolic
FT                   process [PMID:19889839]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0030674
FT                   protein binding, bridging [PMID:15121879]"
FT                   /protein_id="DAA07616.1"
FT                   /translation="MVSLTFKNFKKEKVPLDLEPSNTILETKTKLAQSISCEESQIKLI
FT                   YSGKVLQDSKTVSECGLKDGDQVVFMVSQKKSTKTKVTEPPIAPESATTPGRENSTEAS
FT                   PSTDASAAPAATAPEGSQPQEEQTATTERTESASTPGFVVGTERNETIERIMEMGYQRE
FT                   EVERALRAAFNNPDRAVEYLLMGIPENLRQPEPQQQTAAAAEQPSTAATTAEQPAEDDL
FT                   FAQAAQGGNASSGALGTTGGATDAAQGGPPGSIGLTVEDLLSLRQVVSGNPEALAPLLE
FT                   NISARYPQLREHIMANPEVFVSMLLEAVGDNMQDVMEGADDMVEGEDIEVTGEAAAAGL
FT                   GQGEGEGSFQVDYTPEDDQAISRLCELGFERDLVIQVYFACDKNEEAAANILFSDHAD"
FT   gene            complement(83050..84552)
FT                   /gene="ANP1"
FT                   /gene_synonym="GEM3"
FT                   /gene_synonym="MNN8"
FT                   /locus_tag="YEL036C"
FT   mRNA            complement(83050..84552)
FT                   /gene="ANP1"
FT                   /gene_synonym="GEM3"
FT                   /gene_synonym="MNN8"
FT                   /locus_tag="YEL036C"
FT                   /product="Anp1p"
FT   CDS_pept        complement(83050..84552)
FT                   /codon_start=1
FT                   /gene="ANP1"
FT                   /gene_synonym="GEM3"
FT                   /gene_synonym="MNN8"
FT                   /locus_tag="YEL036C"
FT                   /product="Anp1p"
FT                   /note="Subunit of the alpha-1,6 mannosyltransferase
FT                   complex; type II membrane protein; has a role in retention
FT                   of glycosyltransferases in the Golgi; involved in osmotic
FT                   sensitivity and resistance to aminonitrophenyl propanediol"
FT                   /db_xref="GOA:P32629"
FT                   /db_xref="InterPro:IPR029044"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32629"
FT                   /experiment="EXISTENCE:direct assay:GO:0000009
FT                   alpha-1,6-mannosyltransferase activity [PMID:10037752]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000136
FT                   alpha-1,6-mannosyltransferase complex [PMID:9430634]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis
FT                   cisterna [PMID:9430634]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006487 protein
FT                   N-linked glycosylation [PMID:9430634]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein
FT                   N-linked glycosylation [PMID:9430634]"
FT                   /protein_id="DAA07617.1"
FT                   /translation="MKYNNRKLSFNPTTVSIAGTLLTVFFLTRLVLSFFSISLFQLVTF
FT                   QGIFKPYVPDFKNTPSVEFYDLRNYQGNKDGWQQGDRILFCVPLRDASEHLPMFFNHLN
FT                   TMTYPHNLIDLSFLVSDSSDNTMGVLLSNLQMAQSQQDKSKRFGNIEIYEKDFGQIIGQ
FT                   SFSDRHGFGAQGPRRKLMARARNWLGSVALKPYHSWVYWRDVDVETIPTTIMEDLMHHD
FT                   KDVIVPNVWRPLPDWLGNIQPYDLNSWKESEGGLQLADSLDEDAVIVEGYPEYATWRPH
FT                   LAYMRDPNGNPEDEMELDGIGGVSILAKAKVFRTGSHFPAFSFEKHAETEAFGRLSRRM
FT                   NYNVIGLPHYVIWHIYEPSSDDLKHMAWMAEEEKRKLEEERIREFYNKIWEIGFEDVRD
FT                   QWNEERDSILKNIDSTLNNKVTVDWSEEGDGSELVDSKGDFVSPNNQQQQQQQQQQQQQ
FT                   QQQQQQQQQLDGNPQGKPLDDNDKNKKKHPKEVPLDFDPDRN"
FT   gene            complement(85045..85545)
FT                   /gene="UTR5"
FT                   /locus_tag="YEL035C"
FT   mRNA            complement(85045..85545)
FT                   /gene="UTR5"
FT                   /locus_tag="YEL035C"
FT                   /product="Utr5p"
FT   CDS_pept        complement(85045..85545)
FT                   /codon_start=1
FT                   /gene="UTR5"
FT                   /locus_tag="YEL035C"
FT                   /product="Utr5p"
FT                   /note="hypothetical protein; transcription may be regulated
FT                   by Gcr1p; essential for growth under standard (aerobic)
FT                   conditions but not under anaerobic conditions"
FT                   /db_xref="GOA:P32630"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32630"
FT                   /protein_id="DAA07618.1"
FT                   /translation="MSRYGKNLVHYIIVEHDDQRGQKPIDDDDEKNFYYHCSFTFETFF
FT                   RATAFLLAPAVCAVREVPCRLTRTRYNATEYIEGYGWMISLQQGLGVAEFYRPWPLSVQ
FT                   LQRYTTPSRRSRFAVLTPQRKCHQNEANGQDLSLLILLSRIYPLCSNTSQTRRVAARKG
FT                   KLS"
FT   gene            85676..86149
FT                   /gene="HYP2"
FT                   /gene_synonym="TIF51A"
FT                   /locus_tag="YEL034W"
FT   mRNA            85676..86149
FT                   /gene="HYP2"
FT                   /gene_synonym="TIF51A"
FT                   /locus_tag="YEL034W"
FT                   /product="translation elongation factor eIF-5A"
FT   CDS_pept        85676..86149
FT                   /codon_start=1
FT                   /gene="HYP2"
FT                   /gene_synonym="TIF51A"
FT                   /locus_tag="YEL034W"
FT                   /product="translation elongation factor eIF-5A"
FT                   /note="Translation elongation factor eIF-5A; required for
FT                   translation of proteins containing polyproline stretches,
FT                   including Bni1p, and this leads to a requirement for mating
FT                   projection formation; structural homolog of bacterial EF-P;
FT                   undergoes an essential hypusination modification; HYP2 has
FT                   a paralog, ANB1, that arose from the whole genome
FT                   duplication; human EIF5A complements the inviability of the
FT                   yeast hyp2 anb1 double null mutant"
FT                   /db_xref="GOA:P23301"
FT                   /db_xref="InterPro:IPR001884"
FT                   /db_xref="InterPro:IPR008991"
FT                   /db_xref="InterPro:IPR012340"
FT                   /db_xref="InterPro:IPR014722"
FT                   /db_xref="InterPro:IPR019769"
FT                   /db_xref="InterPro:IPR020189"
FT                   /db_xref="PDB:3ER0"
FT                   /db_xref="PDB:5DAT"
FT                   /db_xref="PDB:5DC3"
FT                   /db_xref="PDB:5DGE"
FT                   /db_xref="PDB:5DGF"
FT                   /db_xref="PDB:5GAK"
FT                   /db_xref="PDB:5MC6"
FT                   /db_xref="PDB:6Q84"
FT                   /db_xref="UniProtKB/Swiss-Prot:P23301"
FT                   /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
FT                   [PMID:19120453]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003743 translation
FT                   initiation factor activity [PMID:21451136]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003746 translation
FT                   elongation factor activity [PMID:19424157]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:11914276]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043022 ribosome
FT                   binding [PMID:16215987]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045901 positive
FT                   regulation of translational elongation [PMID:19424157]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045905 positive
FT                   regulation of translational termination [PMID:19424157]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045948 positive
FT                   regulation of translational initiation [PMID:21451136]"
FT                   /experiment="EXISTENCE:direct assay:GO:0048471 perinuclear
FT                   region of cytoplasm [PMID:11861547]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006452
FT                   translational frameshifting [PMID:19424157]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0045901
FT                   positive regulation of translational elongation
FT                   [PMID:19338753|PMID:19424157]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003746
FT                   translation elongation factor activity [PMID:19424157]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045901 positive
FT                   regulation of translational elongation
FT                   [PMID:19338753|PMID:19424157]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1903272 positive
FT                   regulation of cytoplasmic translational elongation through
FT                   polyproline stretches [PMID:24923804]"
FT                   /protein_id="DAA07619.1"
FT                   /translation="MSDEEHTFETADAGSSATYPMQCSALRKNGFVVIKSRPCKIVDMS
FT                   TSKTGKHGHAKVHLVAIDIFTGKKLEDLSPSTHNMEVPVVKRNEYQLLDIDDGFLSLMN
FT                   MDGDTKDDVKAPEGELGDSLQTAFDEGKDLMVTIISAMGEEAAISFKEAARTD"
FT   gene            86179..86598
FT                   /gene="MTC7"
FT                   /locus_tag="YEL033W"
FT   mRNA            86179..86598
FT                   /gene="MTC7"
FT                   /locus_tag="YEL033W"
FT                   /product="Mtc7p"
FT   CDS_pept        86179..86598
FT                   /codon_start=1
FT                   /gene="MTC7"
FT                   /locus_tag="YEL033W"
FT                   /product="Mtc7p"
FT                   /note="hypothetical protein; predicted metabolic role based
FT                   on network analysis derived from ChIP experiments, a
FT                   large-scale deletion study and localization of
FT                   transcription factor binding sites; null mutant is
FT                   sensitive to temperature oscillation in a cdc13-1 mutant"
FT                   /db_xref="GOA:P32633"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32633"
FT                   /protein_id="DAA07620.1"
FT                   /translation="MKKEKKTPTPLPSHHVLFAEPGFFLCNFFFVLLKHTQINPFFYFL
FT                   FILLFIIYIAIIYFVFIRISHFSFSLCRQCNSLGRMIFMCAYLPAASSRSVANPALPPQ
FT                   KKKKKKKKGTLRTGEVEEQAKGNISFDLCGKQNFQ"
FT   gene            86604..86685
FT                   /locus_tag="tS(AGA)E"
FT   tRNA            86604..86685
FT                   /locus_tag="tS(AGA)E"
FT                   /product="tRNA-Ser"
FT                   /note="tS(AGA)E; Serine tRNA (tRNA-Ser), predicted by
FT                   tRNAscan-SE analysis"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030371 translation
FT                   repressor activity [PMID:27609601]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043022 ribosome
FT                   binding [PMID:27609601]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043555 regulation
FT                   of translation in response to stress [PMID:27609601]"
FT   gene            86937..89852
FT                   /gene="MCM3"
FT                   /locus_tag="YEL032W"
FT   mRNA            86937..89852
FT                   /gene="MCM3"
FT                   /locus_tag="YEL032W"
FT                   /product="MCM DNA helicase complex subunit MCM3"
FT   CDS_pept        86937..89852
FT                   /codon_start=1
FT                   /gene="MCM3"
FT                   /locus_tag="YEL032W"
FT                   /product="MCM DNA helicase complex subunit MCM3"
FT                   /EC_number="3.6.4.12"
FT                   /note="Protein involved in DNA replication; component of
FT                   the Mcm2-7 hexameric helicase complex that binds chromatin
FT                   as a part of the pre-replicative complex"
FT                   /db_xref="GOA:P24279"
FT                   /db_xref="InterPro:IPR001208"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="InterPro:IPR008046"
FT                   /db_xref="InterPro:IPR012340"
FT                   /db_xref="InterPro:IPR018525"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR031327"
FT                   /db_xref="InterPro:IPR033762"
FT                   /db_xref="InterPro:IPR041562"
FT                   /db_xref="PDB:3JA8"
FT                   /db_xref="PDB:3JC5"
FT                   /db_xref="PDB:3JC6"
FT                   /db_xref="PDB:3JC7"
FT                   /db_xref="PDB:5BK4"
FT                   /db_xref="PDB:5H7I"
FT                   /db_xref="PDB:5U8S"
FT                   /db_xref="PDB:5U8T"
FT                   /db_xref="PDB:5V8F"
FT                   /db_xref="PDB:5XF8"
FT                   /db_xref="PDB:6EYC"
FT                   /db_xref="PDB:6F0L"
FT                   /db_xref="PDB:6HV9"
FT                   /db_xref="UniProtKB/Swiss-Prot:P24279"
FT                   /experiment="EXISTENCE:direct assay:GO:0003682 chromatin
FT                   binding [PMID:9554851]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003688 DNA
FT                   replication origin binding [PMID:11756674|PMID:16824194]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:10704410|PMID:8224843]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005656 nuclear
FT                   pre-replicative complex [PMID:16824194|PMID:9335335]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:10704410|PMID:11914276|PMID:8224843]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006267
FT                   pre-replicative complex assembly involved in nuclear cell
FT                   cycle DNA replication [PMID:16824194]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016887 ATPase
FT                   activity [PMID:12480933]"
FT                   /experiment="EXISTENCE:direct assay:GO:0017116
FT                   single-stranded DNA helicase activity [PMID:18657510]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031298 replication
FT                   fork protection complex [PMID:16531994]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042555 MCM complex
FT                   [PMID:12480933]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex
FT                   [PMID:26524492]"
FT                   /experiment="EXISTENCE:direct assay:GO:1904931 MCM complex
FT                   binding [PMID:26912723]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000727
FT                   double-strand break repair via break-induced replication
FT                   [PMID:20516198]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA
FT                   replication initiation [PMID:12060653]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA
FT                   strand elongation involved in DNA replication
FT                   [PMID:10834843]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006348
FT                   chromatin silencing at telomere [PMID:19064704]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATPase
FT                   activity [PMID:12480933]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030466
FT                   chromatin silencing at silent mating-type cassette
FT                   [PMID:19064704]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1902975 mitotic
FT                   DNA replication initiation [PMID:8224843]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031261 DNA
FT                   replication preinitiation complex [PMID:9554851]"
FT                   /protein_id="DAA07621.1"
FT                   /translation="MEGSTGFDGDATTFFAPDAVFGDRVRRFQEFLDTFTSYRDSVRSI
FT                   QVYNSNNAANYNDDQDDADERDLLGDDDGDDLEKEKKAASSTSLNILPHRIIISLDDLR
FT                   EFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHPNASAVSSRHPWKLSFKGSFGA
FT                   HALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGRFHYRDYTDATTTLT
FT                   TRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITVQEMPEMAPAGQLPRSIDVILDDD
FT                   LVDKTKPGDRVNVVGVFKSLGAGGMNQSNSNTLIGFKTLILGNTVYPLHARSTGVAARQ
FT                   MLTDFDIRNINKLSKKKDIFDILSQSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHL
FT                   RGDINILMVGDPSTAKSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLE
FT                   AGAMVLADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIAAAN
FT                   PVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEHVLRTHRYLPPGY
FT                   LEGEPVRERLNLSLAVGEDADINPEEHSNSGAGVENEGEDDEDHVFEKFNPLLQAGAKL
FT                   AKNKGNYNGTEIPKLVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKK
FT                   SPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALLGEDIGNDIDEEESEY
FT                   EEALSKRSPQKSPKKRQRVRQPASNSGSPIKSTPRRSTASSVNATPSSARRILRFQDDE
FT                   QNAGEDDNDIMSPLPADEEAELQRRLQLGLRVSPRRREHLHAPEEGSSGPLTEVGTPRL
FT                   PNVSSAGQDDEQQQSVISFDNVEPGTISTGRLSLISGIIARLMQTEIFEEESYPVASLF
FT                   ERINEELPEEEKFSAQEYLAGLKIMSDRNNLMVADDKVWRV"
FT   gene            90258..93905
FT                   /gene="SPF1"
FT                   /gene_synonym="COD1"
FT                   /gene_synonym="PER9"
FT                   /gene_synonym="PIO1"
FT                   /locus_tag="YEL031W"
FT   mRNA            90258..93905
FT                   /gene="SPF1"
FT                   /gene_synonym="COD1"
FT                   /gene_synonym="PER9"
FT                   /gene_synonym="PIO1"
FT                   /locus_tag="YEL031W"
FT                   /product="ion-transporting P-type ATPase SPF1"
FT   CDS_pept        90258..93905
FT                   /codon_start=1
FT                   /gene="SPF1"
FT                   /gene_synonym="COD1"
FT                   /gene_synonym="PER9"
FT                   /gene_synonym="PIO1"
FT                   /locus_tag="YEL031W"
FT                   /product="ion-transporting P-type ATPase SPF1"
FT                   /note="P-type ATPase, ion transporter of the ER membrane;
FT                   required to maintain normal lipid composition of
FT                   intracellular compartments and proper targeting of
FT                   mitochondrial outer membrane tail-anchored proteins;
FT                   involved in ER function and Ca2+ homeostasis; required for
FT                   regulating Hmg2p degradation; confers sensitivity to a
FT                   killer toxin (SMKT) produced by Pichia farinosa KK1"
FT                   /db_xref="GOA:P39986"
FT                   /db_xref="InterPro:IPR001757"
FT                   /db_xref="InterPro:IPR006544"
FT                   /db_xref="InterPro:IPR008250"
FT                   /db_xref="InterPro:IPR018303"
FT                   /db_xref="InterPro:IPR023214"
FT                   /db_xref="InterPro:IPR023298"
FT                   /db_xref="InterPro:IPR023299"
FT                   /db_xref="InterPro:IPR036412"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39986"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
FT                   reticulum membrane [PMID:12058017|PMID:22745129]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi
FT                   network [PMID:11791712]"
FT                   /experiment="EXISTENCE:direct assay:GO:0015662 ion
FT                   transmembrane transporter activity, phosphorylative
FT                   mechanism [PMID:12058017|PMID:22745129]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006874 cellular
FT                   calcium ion homeostasis [PMID:12058017]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030026 cellular
FT                   manganese ion homeostasis [PMID:24392018]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0055085
FT                   transmembrane transport [PMID:12058017]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0055092 sterol
FT                   homeostasis [PMID:22918956]"
FT                   /protein_id="DAA07622.1"
FT                   /translation="MTKKSFVSSPIVRDSTLLVPKSLIAKPYVLPFFPLYATFAQLYFQ
FT                   QYDRYIKGPEWTFVYLGTLVSLNILVMLMPAWNVKIKAKFNYSTTKNVNEATHILIYTT
FT                   PNNGSDGIVEIQRVTEAGSLQTFFQFQKKRFLWHENEQVFSSPKFLVDESPKIGDFQKC
FT                   KGHSGDLTHLKRLYGENSFDIPIPTFMELFKEHAVAPLFVFQVFCVALWLLDEFWYYSL
FT                   FNLFMIISMEAAAVFQRLTALKEFRTMGIKPYTINVFRNKKWVALQTNELLPMDLVSIT
FT                   RTAEESAIPCDLILLDGSAIVNEAMLSGESTPLLKESIKLRPSEDNLQLDGVDKIAVLH
FT                   GGTKALQVTPPEHKSDIPPPPDGGALAIVTKTGFETSQGSLVRVMIYSAERVSVDNKEA
FT                   LMFILFLLIFAVIASWYVWVEGTKMGRIQSKLILDCILIITSVVPPELPMELTMAVNSS
FT                   LAALAKFYVYCTEPFRIPFAGRIDVCCFDKTGTLTGEDLVFEGLAGISADSENIRHLYS
FT                   AAEAPESTILVIGAAHALVKLEDGDIVGDPMEKATLKAVGWAVERKNSNYREGTGKLDI
FT                   IRRFQFSSALKRSASIASHNDALFAAVKGAPETIRERLSDIPKNYDEIYKSFTRSGSRV
FT                   LALASKSLPKMSQSKIDDLNRDDVESELTFNGFLIFHCPLKDDAIETIKMLNESSHRSI
FT                   MITGDNPLTAVHVAKEVGIVFGETLILDRAGKSDDNQLLFRDVEETVSIPFDPSKDTFD
FT                   HSKLFDRYDIAVTGYALNALEGHSQLRDLLRHTWVYARVSPSQKEFLLNTLKDMGYQTL
FT                   MCGDGTNDVGALKQAHVGIALLNGTEEGLKKLGEQRRLEGMKMMYIKQTEFMARWNQPQ
FT                   PPVPEPIAHLFPPGPKNPHYLKALESKGTVITPEIRKAVEEANSKPVEVIKPNGLSEKK
FT                   PADLASLLLNSAGDAQGDEAPALKLGDASCAAPFTSKLANVSAVTNIIRQGRCALVNTI
FT                   QMYKILALNCLISAYSLSIIYMAGVKFGDGQATVSGLLLSVCFLSISRGKPLEKLSKQR
FT                   PQSGIFNVYIMGSILSQFAVHIATLVYITTEIYKLEPREPQVDLEKEFAPSLLNTGIFI
FT                   IQLVQQVSTFAVNYQGEPFRENIRSNKGMYYGLLGVTGLALASATEFLPELNEAMKFVP
FT                   MTDDFKIKLTLTLLLDFFGSWGVEHFFKFFFMDDKPSDISVQQVKIASK"
FT   rep_origin      93978..94218
FT                   /note="ARS508; Autonomously Replicating Sequence"
FT   gene            94644..96578
FT                   /gene="ECM10"
FT                   /gene_synonym="SSC3"
FT                   /locus_tag="YEL030W"
FT   mRNA            94644..96578
FT                   /gene="ECM10"
FT                   /gene_synonym="SSC3"
FT                   /locus_tag="YEL030W"
FT                   /product="Hsp70 family ATPase ECM10"
FT   CDS_pept        94644..96578
FT                   /codon_start=1
FT                   /gene="ECM10"
FT                   /gene_synonym="SSC3"
FT                   /locus_tag="YEL030W"
FT                   /product="Hsp70 family ATPase ECM10"
FT                   /note="Heat shock protein of the Hsp70 family; localized in
FT                   mitochondrial nucleoids, plays a role in protein
FT                   translocation, interacts with Mge1p in an ATP-dependent
FT                   manner; overexpression induces extensive mitochondrial DNA
FT                   aggregations; ECM10 has a paralog, SSC1, that arose from
FT                   the whole genome duplication"
FT                   /db_xref="GOA:P39987"
FT                   /db_xref="InterPro:IPR012725"
FT                   /db_xref="InterPro:IPR013126"
FT                   /db_xref="InterPro:IPR018181"
FT                   /db_xref="InterPro:IPR029047"
FT                   /db_xref="InterPro:IPR029048"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39987"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion
FT                   [PMID:11150530|PMID:14576278|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006626 protein
FT                   targeting to mitochondrion [PMID:11150530]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042645
FT                   mitochondrial nucleoid [PMID:12943685]"
FT                   /protein_id="DAA07623.1"
FT                   /translation="MLPSWKAFKAHNILRILTRFQSTKIPDAVIGIDLGTTNSAVAIME
FT                   GKVPRIIENAEGSRTTPSVVAFTKDGERLVGEPAKRQSVINSENTLFATKRLIGRRFED
FT                   AEVQRDINQVPFKIVKHSNGDAWVEARNRTYSPAQIGGFILNKMKETAEAYLAKSVKNA
FT                   VVTVPAYFNDAQRQATKDAGQIIGLNVLRVVNEPTAAALAYGLDKSEPKVIAVFDLGGG
FT                   TFDISILDIDNGIFEVKSTNGDTHLGGEDFDIYLLQEIISHFKKETGIDLSNDRMAVQR
FT                   IREAAEKAKIELSSTLSTEINLPFITADAAGPKHIRMPFSRVQLENITAPLIDRTVDPV
FT                   KKALKDARITASDISDVLLVGGMSRMPKVADTVKKLFGKDASKAVNPDEAVALGAAIQA
FT                   AVLSGEVTDVLLLDVTPLSLGIETLGGVFTKLIPRNSTIPNKKSQIFSTAASGQTSVEV
FT                   KVFQGERELVKDNKLIGNFTLAGIPPAPKGTPQIEVTFDIDANGIINVSAKDLASHKDS
FT                   SITVAGASGLSDTEIDRMVNEAERYKNQDRARRNAIETANKADQLANDTENSIKEFEGK
FT                   LDKTDSQRLKDQISSLRELVSRSQAGDEVNDDDVGTKIDNLRTSSMKLFEQLYKNSDNP
FT                   ETKNGRENK"
FT   gene            complement(96858..97796)
FT                   /gene="BUD16"
FT                   /locus_tag="YEL029C"
FT   mRNA            complement(96858..97796)
FT                   /gene="BUD16"
FT                   /locus_tag="YEL029C"
FT                   /product="putative pyridoxal kinase BUD16"
FT   CDS_pept        complement(96858..97796)
FT                   /codon_start=1
FT                   /gene="BUD16"
FT                   /locus_tag="YEL029C"
FT                   /product="putative pyridoxal kinase BUD16"
FT                   /EC_number="2.7.1.35"
FT                   /note="Putative pyridoxal kinase; a key enzyme involved in
FT                   pyridoxal 5'-phosphate synthesis, the active form of
FT                   vitamin B6; required for genome integrity; involved in
FT                   bud-site selection; similarity to yeast BUD17 and human
FT                   pyridoxal kinase (PDXK)"
FT                   /db_xref="GOA:P39988"
FT                   /db_xref="InterPro:IPR004625"
FT                   /db_xref="InterPro:IPR013749"
FT                   /db_xref="InterPro:IPR029056"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39988"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0042823
FT                   pyridoxal phosphate biosynthetic process [PMID:17696614]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042823
FT                   pyridoxal phosphate biosynthetic process [PMID:17696614]"
FT                   /protein_id="DAA07624.1"
FT                   /translation="MPRLLATQSHVVHGYVGNKAATFPLQCLGWDVDCCNSVQFSNHTG
FT                   YGLDKVFGTITRETDLKELLSGLFDNFSQDYQALLSGYLPNKNSVRCMGTYYAKFKEAN
FT                   PEMIWLMDPVMGDEGQLYVSEDVIPEYRKLALSPKQLVDIITPNQFELEILYGGEIKTK
FT                   EHLKKALKKLHQTIPVIIVTSCDCKMFDDKDFIYCVASMEGKTPIVYRVPFIDSYFTGV
FT                   GDLFSALLLDRVYKILSNPTTTLKFEDQVNNVLNVIQKVLKITRSYASGKMKAKMGSAL
FT                   EMKEMELRLIESRDIYETINIHQTDYIYARL"
FT   gene            98668..99129
FT                   /locus_tag="YEL028W"
FT   mRNA            98668..99129
FT                   /locus_tag="YEL028W"
FT                   /product="hypothetical protein"
FT   CDS_pept        98668..99129
FT                   /codon_start=1
FT                   /locus_tag="YEL028W"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; conserved among S. cerevisiae
FT                   strains; YEL028W is not an essential gene"
FT                   /db_xref="GOA:P39989"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39989"
FT                   /protein_id="DAA80284.1"
FT                   /translation="MKITITSLLFFLVMIVELASAGTLLHNGANLPSLRDNTTLTDARN
FT                   VLKYLQVLGFPSNKIAATDTVGTFIIFSNRTEANTTAMTKTVSYCYRNYGHSFYFTHYK
FT                   YDYFPSGISYMAKLGDATVNHTDLPHFRNNKRLTTQELNAFQHPIVEFQ"
FT   repeat_region   complement(99490..99664)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            100133..100204
FT                   /gene="IMT4"
FT                   /locus_tag="tM(CAU)E"
FT   tRNA            100133..100204
FT                   /gene="IMT4"
FT                   /locus_tag="tM(CAU)E"
FT                   /product="tRNA-Met"
FT                   /note="tM(CAU)E; Methionine initiator tRNA (tRNA-Met);
FT                   predicted by tRNAscan-SE analysis; one of four initiator
FT                   methionine tRNAs in yeast that are functional for
FT                   translation"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006413
FT                   translational initiation [PMID:9023104]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic
FT                   43S preinitiation complex [PMID:12008673]"
FT                   /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic
FT                   48S preinitiation complex [PMID:17242201]"
FT   gene            100769..101251
FT                   /gene="VMA3"
FT                   /gene_synonym="CLS7"
FT                   /gene_synonym="CUP5"
FT                   /gene_synonym="GEF2"
FT                   /locus_tag="YEL027W"
FT   mRNA            100769..101251
FT                   /gene="VMA3"
FT                   /gene_synonym="CLS7"
FT                   /gene_synonym="CUP5"
FT                   /gene_synonym="GEF2"
FT                   /locus_tag="YEL027W"
FT                   /product="H(+)-transporting V0 sector ATPase subunit c"
FT   CDS_pept        100769..101251
FT                   /codon_start=1
FT                   /gene="VMA3"
FT                   /gene_synonym="CLS7"
FT                   /gene_synonym="GEF2"
FT                   /gene_synonym="CUP5"
FT                   /locus_tag="YEL027W"
FT                   /product="H(+)-transporting V0 sector ATPase subunit c"
FT                   /note="Proteolipid subunit c of the V0 domain of vacuolar
FT                   H(+)-ATPase; dicyclohexylcarbodiimide binding subunit;
FT                   required for vacuolar acidification and important for
FT                   copper and iron metal ion homeostasis"
FT                   /db_xref="GOA:P25515"
FT                   /db_xref="InterPro:IPR000245"
FT                   /db_xref="InterPro:IPR002379"
FT                   /db_xref="InterPro:IPR011555"
FT                   /db_xref="InterPro:IPR035921"
FT                   /db_xref="PDB:3J9T"
FT                   /db_xref="PDB:3J9U"
FT                   /db_xref="PDB:3J9V"
FT                   /db_xref="PDB:5TJ5"
FT                   /db_xref="PDB:5VOX"
FT                   /db_xref="PDB:5VOY"
FT                   /db_xref="PDB:5VOZ"
FT                   /db_xref="PDB:6C6L"
FT                   /db_xref="PDB:6O7T"
FT                   /db_xref="PDB:6O7U"
FT                   /db_xref="PDB:6O7V"
FT                   /db_xref="PDB:6O7W"
FT                   /db_xref="PDB:6O7X"
FT                   /db_xref="UniProtKB/Swiss-Prot:P25515"
FT                   /experiment="EXISTENCE:direct assay:GO:0016021 integral
FT                   component of membrane [PMID:15252052]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein
FT                   targeting to vacuole [PMID:2145283]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006878 cellular
FT                   copper ion homeostasis [PMID:9434348]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006879 cellular
FT                   iron ion homeostasis [PMID:9434348]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006897
FT                   endocytosis [PMID:2145283]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole
FT                   organization [PMID:2145283]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar
FT                   acidification [PMID:2145283]"
FT                   /protein_id="DAA07625.1"
FT                   /translation="MTELCPVYAPFFGAIGCASAIIFTSLGAAYGTAKSGVGICATCVL
FT                   RPDLLFKNIVPVIMAGIIAIYGLVVSVLVCYSLGQKQALYTGFIQLGAGLSVGLSGLAA
FT                   GFAIGIVGDAGVRGSSQQPRLFVGMILILIFAEVLGLYGLIVALLLNSRATQDVVC"
FT   gene            101943..102323
FT                   /gene="SNU13"
FT                   /locus_tag="YEL026W"
FT   mRNA            101943..102323
FT                   /gene="SNU13"
FT                   /locus_tag="YEL026W"
FT                   /product="RNA binding protein SNU13"
FT   CDS_pept        101943..102323
FT                   /codon_start=1
FT                   /gene="SNU13"
FT                   /locus_tag="YEL026W"
FT                   /product="RNA binding protein SNU13"
FT                   /note="RNA binding protein; part of U3 snoRNP involved in
FT                   rRNA processing, part of U4/U6-U5 tri-snRNP involved in
FT                   mRNA splicing, similar to human 15.5K protein"
FT                   /db_xref="GOA:P39990"
FT                   /db_xref="InterPro:IPR002415"
FT                   /db_xref="InterPro:IPR004037"
FT                   /db_xref="InterPro:IPR004038"
FT                   /db_xref="InterPro:IPR018492"
FT                   /db_xref="InterPro:IPR029064"
FT                   /db_xref="PDB:1ZWZ"
FT                   /db_xref="PDB:2ALE"
FT                   /db_xref="PDB:3JCM"
FT                   /db_xref="PDB:4NUT"
FT                   /db_xref="PDB:5GAN"
FT                   /db_xref="PDB:5GAP"
FT                   /db_xref="PDB:5NRL"
FT                   /db_xref="PDB:5TZS"
FT                   /db_xref="PDB:5WLC"
FT                   /db_xref="PDB:5WYJ"
FT                   /db_xref="PDB:5WYK"
FT                   /db_xref="PDB:5ZWM"
FT                   /db_xref="PDB:5ZWO"
FT                   /db_xref="PDB:6ND4"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39990"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:10684247]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030621 U4 snRNA
FT                   binding [PMID:17631273|PMID:14730029]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031428 box C/D
FT                   snoRNP complex [PMID:11081632]"
FT                   /experiment="EXISTENCE:direct assay:GO:0032040
FT                   small-subunit processome [PMID:12068309]"
FT                   /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA
FT                   binding [PMID:17631273|PMID:14730029]"
FT                   /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5
FT                   tri-snRNP complex [PMID:10377396|PMID:10449419]"
FT                   /experiment="EXISTENCE:direct assay:GO:1905216 positive
FT                   regulation of RNA binding [PMID:23509373]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA
FT                   splicing, via spliceosome [PMID:11720284|PMID:14730029]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000462
FT                   maturation of SSU-rRNA from tricistronic rRNA transcript
FT                   (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14730029]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003723 RNA
FT                   binding [PMID:14730029]"
FT                   /protein_id="DAA07626.1"
FT                   /translation="MSAPNPKAFPLADAALTQQILDVVQQAANLRQLKKGANEATKTLN
FT                   RGISEFIIMAADCEPIEILLHLPLLCEDKNVPYVFVPSRVALGRACGVSRPVIAASITT
FT                   NDASAIKTQIYAVKDKIETLLI"
FT   gene            complement(102581..106147)
FT                   /locus_tag="YEL025C"
FT   mRNA            complement(102581..106147)
FT                   /locus_tag="YEL025C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(102581..106147)
FT                   /codon_start=1
FT                   /locus_tag="YEL025C"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; green fluorescent protein
FT                   (GFP)-fusion protein localizes to both the cytoplasm and
FT                   the nucleus"
FT                   /db_xref="GOA:P39991"
FT                   /db_xref="InterPro:IPR036322"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39991"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095|PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /protein_id="DAA07627.1"
FT                   /translation="MARQDETDCKKLDSNSAFLPLCITSYRSKDEAEKLVSCLHHEGSY
FT                   FLCFSYGLYTGTSNELKAKVEFALDGPFVVNYATVPMFMSASFCHLLMFNDGSIKGFKC
FT                   ENNKFEIIYDSNVAPKLDTISLLTSSWLNASFEGVLYTCNKNISYDSDLHTLCTTIYSF
FT                   DFREGIVERFYATDGEEIISFDFISREDLLDDATCTGKSHVYFLCLLKSCYSENLFLKE
FT                   YNLAGKHGSRKFDLNEYRQYNLLPICDNEFCYMKVVCGHTIVVLTTNYTQIINIKASGL
FT                   TNGAFFNNKGLPNVENYQFLKDSYDVIYERSVILLTISDVYANKYTAKIHTRSLHRDHV
FT                   LKELQWTKERVFKPPKHDLCDVILQLPREKYIAVTRINGVNFISKDHRGSKLEKVKSGP
FT                   AYTNKVYLASQVIGNKGTDIDSLLLGGSFNSRRGFLEKKILVYDKTLFKLVTSSKALVE
FT                   NVTDFWVTDLALNGGDEFAYESGGLIYKNGIFLMDEPYDYGLFVSRTGKVLKAGMDGST
FT                   GEFRQVDFLQSNHNSSTMFCYPVQNSKLRISILEAKSGFLRKKEEFFIHGLNSKESIVS
FT                   CFSDGAEKYLFVIYLDGVFSVWNANQKKVATSHPDYSFIAYDQLIKISWLSKKHKHDSI
FT                   YVIASSYTGCVRVYKSESNFLRVDLEIHSLYDQKLELLDTIPSLPLVFLYNDKEIILLN
FT                   LQNMSYGCIQLGLVPRRMRIRPGKALFSLCVLDYDSRISIFEFGSTFYREGFTKQMTSL
FT                   KPQLENHIFYLPSIPVELYTVPNNLNQAVVCLVDSNSRQYKLMLFNYASMKAVSTFSFS
FT                   DEKYLHAVVKPLWPEQNSIYLSQRPFYGNKFVVCLGVGEKRTKFWLFEIRNNNITQLYA
FT                   NYLEDCIFSVFIYYECNLVLFSGDSGIAAYKINMLKEGAEILEAYSFPALSSINHIGLP
FT                   AYMSGDYLVQFEILRDFLRTRFPIRTSIVYPSEYPECPYLGFKRLGSITQVATKIIPKK
FT                   LREPKNDCLASDKNYLLGRLSDLSCATLKYSNRSYVATIGIDNTLTIYEDSKLSVDKGG
FT                   LAMPYLKIRLPNKIISLAAIPDGFQNLQICPNFNSQRLEGVIPLFLLCGTEGQIYIISE
FT                   FIGELWMRTLHDYKKIKLECKRAFRRSEKSMRNVTKQYSVSKETGINESGFDELARNSK
FT                   RRHIDHSPYKTIDFFDPVKLKR"
FT   gene            107260..107907
FT                   /gene="RIP1"
FT                   /locus_tag="YEL024W"
FT   mRNA            107260..107907
FT                   /gene="RIP1"
FT                   /locus_tag="YEL024W"
FT                   /product="ubiquinol--cytochrome-c reductase catalytic
FT                   subunit RIP1"
FT   CDS_pept        107260..107907
FT                   /codon_start=1
FT                   /gene="RIP1"
FT                   /locus_tag="YEL024W"
FT                   /product="ubiquinol--cytochrome-c reductase catalytic
FT                   subunit RIP1"
FT                   /EC_number="7.1.1.8"
FT                   /note="Ubiquinol-cytochrome-c reductase; a Rieske
FT                   iron-sulfur protein of the mitochondrial cytochrome bc1
FT                   complex; transfers electrons from ubiquinol to cytochrome
FT                   c1 during respiration; during import, Rip1p is first
FT                   imported into the mitochondrial matrix where it is
FT                   processed, acquires its Fe-S cluster, and is folded, then
FT                   is translocated into the inner membrane by the action of a
FT                   homo-oligomer of Bcs1p, and finally is delivered by Bcs1p
FT                   to Complex III for assembly"
FT                   /db_xref="GOA:P08067"
FT                   /db_xref="InterPro:IPR004192"
FT                   /db_xref="InterPro:IPR005805"
FT                   /db_xref="InterPro:IPR006317"
FT                   /db_xref="InterPro:IPR014349"
FT                   /db_xref="InterPro:IPR017941"
FT                   /db_xref="InterPro:IPR036922"
FT                   /db_xref="InterPro:IPR037008"
FT                   /db_xref="PDB:1EZV"
FT                   /db_xref="PDB:1KB9"
FT                   /db_xref="PDB:1KYO"
FT                   /db_xref="PDB:1P84"
FT                   /db_xref="PDB:2IBZ"
FT                   /db_xref="PDB:3CX5"
FT                   /db_xref="PDB:3CXH"
FT                   /db_xref="PDB:4PD4"
FT                   /db_xref="PDB:6GIQ"
FT                   /db_xref="PDB:6HU9"
FT                   /db_xref="UniProtKB/Swiss-Prot:P08067"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005750
FT                   mitochondrial respiratory chain complex III
FT                   [PMID:10873857|PMID:3036836]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006122
FT                   mitochondrial electron transport, ubiquinol to cytochrome c
FT                   [PMID:3036836]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008121
FT                   ubiquinol-cytochrome-c reductase activity [PMID:2537289]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic
FT                   respiration [PMID:3036836]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005739
FT                   mitochondrion [PMID:16962558]"
FT                   /protein_id="DAA07628.1"
FT                   /translation="MLGIRSSVKTCFKPMSLTSKRLISQSLLASKSTYRTPNFDDVLKE
FT                   NNDADKGRSYAYFMVGAMGLLSSAGAKSTVETFISSMTATADVLAMAKVEVNLAAIPLG
FT                   KNVVVKWQGKPVFIRHRTPHEIQEANSVDMSALKDPQTDADRVKDPQWLIMLGICTHLG
FT                   CVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEIPAYEFDGDKVIVG"
FT   gene            complement(108504..110552)
FT                   /locus_tag="YEL023C"
FT   mRNA            complement(108504..110552)
FT                   /locus_tag="YEL023C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(108504..110552)
FT                   /codon_start=1
FT                   /locus_tag="YEL023C"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; expression is increased
FT                   greatly during sporulation; YEL023C is not an essential
FT                   gene"
FT                   /db_xref="GOA:P39992"
FT                   /db_xref="InterPro:IPR018712"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39992"
FT                   /protein_id="DAA07629.1"
FT                   /translation="MDSFNYIHGKYKKNGTGGDRSINPSSHSSSGKNIILCFDGTRENF
FT                   GPQPFTNILKLYNLLENGDSSEQICYYQPGIGSVGFDAVVDVRRRLTISHLQNLLDSMF
FT                   AFSLDNHICSAYLFLMKYFEPGDRIYMFGFSRGAFIARVLAGMIERVGLLSKGLEEMVK
FT                   MAWQIYEKWEYDSQPNELQYTSTLAEEFKKTFSRDYEVKIHFQGLFDSVNSVGILRDRL
FT                   FPCTQRSNIVEHVRHCVSLDERRGKFKQLCFTPMPYIPKLFSLTYCNHITDQCSPVPTS
FT                   NALMRDLTPENPLIKYTLKSGAHSISNPSPLIPDNPGRLLSSKSEETTELLLDLNSFLE
FT                   GNSYARDTECSTRGIEAIFQLQSIQGSGTSSRMTMTPDLIEKWFPGDHSDVGGGWAPDC
FT                   ETEENLSNLTLRWILAEAIKFGVKFKPGAIHDFATKHTSIGSLFADTHDYLSFNSPKKC
FT                   SLLGVSDNEDGAREDKSGRNERMEDCLKNIKETRLSLKDEKEKVKDAFTLKCGHANKFM
FT                   RLVWWVLELLPIGIRMENKEGKWQNFHTPNLGRSRYVPEYVSLHWSVYWRIKFDRRYRP
FT                   DNMPEYVRQLFQDLEGIDLKSNKVSNKYDKQDNSNGSEINGGFFDNEEGQELHMGQKAS
FT                   YFATTYNSRLFDSKYSQLKKKFMDWDSNSWTDIPDDLKIYLQQDESL"
FT   gene            111421..115800
FT                   /gene="GEA2"
FT                   /locus_tag="YEL022W"
FT   mRNA            111421..115800
FT                   /gene="GEA2"
FT                   /locus_tag="YEL022W"
FT                   /product="Arf family guanine nucleotide exchange factor
FT                   GEA2"
FT   CDS_pept        111421..115800
FT                   /codon_start=1
FT                   /gene="GEA2"
FT                   /locus_tag="YEL022W"
FT                   /product="Arf family guanine nucleotide exchange factor
FT                   GEA2"
FT                   /note="Guanine nucleotide exchange factor for ADP
FT                   ribosylation factors (ARFs); involved in vesicular
FT                   transport between the Golgi and ER, Golgi organization, and
FT                   actin cytoskeleton organization; GEA2 has a paralog, GEA1,
FT                   that arose from the whole genome duplication"
FT                   /db_xref="GOA:P39993"
FT                   /db_xref="InterPro:IPR000904"
FT                   /db_xref="InterPro:IPR023394"
FT                   /db_xref="InterPro:IPR032691"
FT                   /db_xref="InterPro:IPR035999"
FT                   /db_xref="PDB:1KU1"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39993"
FT                   /experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis
FT                   cisterna [PMID:11294905]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005086 ARF
FT                   guanyl-nucleotide exchange factor activity [PMID:10430582]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0019898 extrinsic
FT                   component of membrane [PMID:15930122]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006890
FT                   retrograde vesicle-mediated transport, Golgi to endoplasmic
FT                   reticulum [PMID:11294905]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0030036 actin
FT                   cytoskeleton organization [PMID:14668359]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006888
FT                   endoplasmic reticulum to Golgi vesicle-mediated transport
FT                   [PMID:11493664]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006891
FT                   intra-Golgi vesicle-mediated transport [PMID:11493664]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016236
FT                   macroautophagy [PMID:20444982]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0033363
FT                   secretory granule organization [PMID:14734650]"
FT                   /protein_id="DAA07630.1"
FT                   /translation="MSDREFVTVDPVTIIIKECINLSTAMRKYSKFTSQSGVAALLGGG
FT                   SEIFSNQDDYLAHTFNNLNTNKHNDPFLSGFIQLRLMLNKLKNLDNIDSLTILQPFLLI
FT                   VSTSSISGYITSLALDSLQKFFTLNIINESSQNYIGAHRATVNALTHCRFEGSQQLSDD
FT                   SVLLKVVFLLRSIVDSPYGDLLSNSIIYDVLQTILSLACNNRRSEVLRNAAQSTMIAVT
FT                   VKIFSKLKTIEPVNVNQIYINDESYTNDVLKADTIGTNVESKEEGSQEDPIGMKVNNEE
FT                   AISEDDGIEEEHIHSEKSTNGAEQLDIVQKTTRSNSRIQAYADDNYGLPVVRQYLNLLL
FT                   SLIAPENELKHSYSTRIFGLELIQTALEISGDRLQLYPRLFTLISDPIFKSILFIIQNT
FT                   TKLSLLQATLQLFTTLVVILGNNLQLQIELTLTRIFSILLDDGTANNSSSENKNKPSII
FT                   KELLIEQISILWTRSPSFFTSTFINFDCNLDRADVSINFLKALTKLALPESALTTTESV
FT                   PPICLEGLVSLVDDMFDHMKDIDREEFGRQKNEMEILKKRDRKTEFIECTNAFNEKPKK
FT                   GIPMLIEKGFIASDSDKDIAEFLFNNNNRMNKKTIGLLLCHPDKVSLLNEYIRLFDFSG
FT                   LRVDEAIRILLTKFRLPGESQQIERIIEAFSSAYCENQDYDPSKISDNAEDDISTVQPD
FT                   ADSVFILSYSIIMLNTDLHNPQVKEHMSFEDYSGNLKGCCNHKDFPFWYLDRIYCSIRD
FT                   KEIVMPEEHHGNEKWFEDAWNNLISSTTVITEIKKDTQSVMDKLTPLELLNFDRAIFKQ
FT                   VGPSIVSTLFNIYVVASDDHISTRMITSLDKCSYISAFFDFKDLFNDILNSIAKGTTLI
FT                   NSSHDDELSTLAFEYGPMPLVQIKFEDTNTEIPVSTDAVRFGRSFKGQLNTVVFFRIIR
FT                   RNKDPKIFSKELWLNIVNIILTLYEDLILSPDIFPDLQKRLKLSNLPKPSPEISINKSK
FT                   ESKGLLSTFASYLKGDEEPTEEEIKSSKKAMECIKSSNIAASVFGNESNITADLIKTLL
FT                   DSAKTEKNADNSRYFEAELLFIIELTIALFLFCKEEKELGKFILQKVFQLSHTKGLTKR
FT                   TVRRMLTYKILLISLCADQTEYLSKLINDELLKKGDIFTQKFFATNQGKEFLKRLFSLT
FT                   ESEFYRGFLLGNENFWKFLRKVTAMKEQSESIFEYLNESIKTDSNILTNENFMWVLGLL
FT                   DEISSMGAVGNHWEIEYKKLTESGHKIDKENPYKKSIELSLKSIQLTSHLLEDNNDLRK
FT                   NEIFAIIQALAHQCINPCKQISEFAVVTLEQTLINKIEIPTNEMESVEELIEGGLLPLL
FT                   NSSETQEDQKILISSILTIISNVYLHYLKLGKTSNETFLKILSIFNKFVEDSDIEKKLQ
FT                   QLILDKKSIEKGNGSSSHGSAHEQTPESNDVEIEATAPIDDNTDDDNKPKLSDVEKD"
FT   gene            116167..116970
FT                   /gene="URA3"
FT                   /locus_tag="YEL021W"
FT   mRNA            116167..116970
FT                   /gene="URA3"
FT                   /locus_tag="YEL021W"
FT                   /product="orotidine-5'-phosphate decarboxylase"
FT   CDS_pept        116167..116970
FT                   /codon_start=1
FT                   /gene="URA3"
FT                   /locus_tag="YEL021W"
FT                   /product="orotidine-5'-phosphate decarboxylase"
FT                   /EC_number="4.1.1.23"
FT                   /note="Orotidine-5'-phosphate (OMP) decarboxylase;
FT                   catalyzes the sixth enzymatic step in the de novo
FT                   biosynthesis of pyrimidines, converting OMP into uridine
FT                   monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a
FT                   toxic compound"
FT                   /db_xref="GOA:P03962"
FT                   /db_xref="InterPro:IPR001754"
FT                   /db_xref="InterPro:IPR011060"
FT                   /db_xref="InterPro:IPR013785"
FT                   /db_xref="InterPro:IPR014732"
FT                   /db_xref="InterPro:IPR018089"
FT                   /db_xref="PDB:1DQW"
FT                   /db_xref="PDB:1DQX"
FT                   /db_xref="PDB:3GDK"
FT                   /db_xref="PDB:3GDL"
FT                   /db_xref="PDB:3GDM"
FT                   /db_xref="PDB:3GDR"
FT                   /db_xref="PDB:3GDT"
FT                   /db_xref="UniProtKB/Swiss-Prot:P03962"
FT                   /experiment="EXISTENCE:direct assay:GO:0004590
FT                   orotidine-5'-phosphate decarboxylase activity
FT                   [PMID:2061334]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:18812321]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006222 UMP
FT                   biosynthetic process [PMID:2061334]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004590
FT                   orotidine-5'-phosphate decarboxylase activity
FT                   [PMID:4550660|PMID:5651325]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006207 'de
FT                   novo' pyrimidine nucleobase biosynthetic process
FT                   [PMID:4550660|PMID:5651325]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006222 UMP
FT                   biosynthetic process [PMID:4550660|PMID:5651325]"
FT                   /protein_id="DAA07631.1"
FT                   /translation="MSKATYKERAATHPSPVAAKLFNIMHEKQTNLCASLDVRTTKELL
FT                   ELVEALGPKICLLKTHVDILTDFSMEGTVKPLKALSAKYNFLLFEDRKFADIGNTVKLQ
FT                   YSAGVYRIAEWADITNAHGVVGPGIVSGLKQAAEEVTKEPRGLLMLAELSCKGSLATGE
FT                   YTKGTVDIAKSDKDFVIGFIAQRDMGGRDEGYDWLIMTPGVGLDDKGDALGQQYRTVDD
FT                   VVSTGSDIIIVGRGLFAKGRDAKVEGERYRKAGWEAYLRRCGQQN"
FT   gene            117211..117474
FT                   /gene="TIM9"
FT                   /locus_tag="YEL020W-A"
FT   mRNA            117211..117474
FT                   /gene="TIM9"
FT                   /locus_tag="YEL020W-A"
FT                   /product="protein transporter TIM9"
FT   CDS_pept        117211..117474
FT                   /codon_start=1
FT                   /gene="TIM9"
FT                   /locus_tag="YEL020W-A"
FT                   /product="protein transporter TIM9"
FT                   /note="Essential protein of the mitochondrial intermembrane
FT                   space; forms a complex with Tim10p (TIM10 complex) that
FT                   delivers hydrophobic proteins to the TIM22 complex for
FT                   insertion into the inner membrane"
FT                   /db_xref="GOA:O74700"
FT                   /db_xref="InterPro:IPR004217"
FT                   /db_xref="InterPro:IPR035427"
FT                   /db_xref="InterPro:IPR039094"
FT                   /db_xref="PDB:3DXR"
FT                   /db_xref="UniProtKB/Swiss-Prot:O74700"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042719
FT                   mitochondrial intermembrane space protein transporter
FT                   complex [PMID:9822593|PMID:9889188]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042721 TIM22
FT                   mitochondrial import inner membrane insertion complex
FT                   [PMID:9495346]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045039 protein
FT                   insertion into mitochondrial inner membrane
FT                   [PMID:10469659|PMID:9822593]"
FT                   /experiment="EXISTENCE:direct assay:GO:0051082 unfolded
FT                   protein binding [PMID:12138093]"
FT                   /experiment="EXISTENCE:direct assay:GO:0140318 protein
FT                   transporter activity [PMID:9822593]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0045039
FT                   protein insertion into mitochondrial inner membrane
FT                   [PMID:9822593]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0140318
FT                   protein transporter activity [PMID:9822593]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein
FT                   insertion into mitochondrial inner membrane [PMID:9889188]"
FT                   /protein_id="DAA07632.1"
FT                   /translation="MDALNSKEQQEFQKVVEQKQMKDFMRLYSNLVERCFTDCVNDFTT
FT                   SKLTNKEQTCIMKCSEKFLKHSERVGQRFQEQNAALGQGLGR"
FT   gene            complement(117667..118035)
FT                   /locus_tag="RPR1"
FT   ncRNA           complement(117667..118035)
FT                   /locus_tag="RPR1"
FT                   /product="RPR1"
FT                   /note="RNA component of nuclear RNase P; nuclear RNase P
FT                   cleaves tRNA precursors to generate mature 5' ends and
FT                   facilitates turnover of nuclear RNAs; may be responsible
FT                   for recognition of substrate tRNAs"
FT                   /experiment="EXISTENCE:direct assay:GO:0004526 ribonuclease
FT                   P activity [PMID:19095620|PMID:9620854]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar
FT                   ribonuclease P complex [PMID:19095620|PMID:9620854]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008033 tRNA
FT                   processing [PMID:9620854]"
FT                   /experiment="EXISTENCE:direct assay:GO:0034965 intronic box
FT                   C/D snoRNA processing [PMID:18713869]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004526
FT                   ribonuclease P activity [PMID:1990278]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA
FT                   processing [PMID:1990278]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034965 intronic
FT                   box C/D snoRNA processing [PMID:18713869]"
FT                   /ncRNA_class="RNase_P_RNA"
FT   repeat_region   complement(118230..118551)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty4 LTR"
FT   gene            complement(118617..120299)
FT                   /gene="PXP1"
FT                   /locus_tag="YEL020C"
FT   mRNA            complement(118617..120299)
FT                   /gene="PXP1"
FT                   /locus_tag="YEL020C"
FT                   /product="putative indolepyruvate decarboxylase family
FT                   protein"
FT   CDS_pept        complement(118617..120299)
FT                   /codon_start=1
FT                   /gene="PXP1"
FT                   /locus_tag="YEL020C"
FT                   /product="putative indolepyruvate decarboxylase family
FT                   protein"
FT                   /note="Peroxisomal matrix protein; well-conserved in fungi;
FT                   contains tripartite homology domain of thiamine
FT                   pyrophosphate (TPP) enzymes; targeted to peroxisomes by
FT                   Pex5p; contains low sequence identity with Pdc1p; mRNA
FT                   identified as translated by ribosome profiling data"
FT                   /db_xref="GOA:P39994"
FT                   /db_xref="InterPro:IPR000399"
FT                   /db_xref="InterPro:IPR011766"
FT                   /db_xref="InterPro:IPR012000"
FT                   /db_xref="InterPro:IPR012001"
FT                   /db_xref="InterPro:IPR029035"
FT                   /db_xref="InterPro:IPR029061"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39994"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
FT                   [PMID:27392156|PMID:26928762]"
FT                   /protein_id="DAA07633.1"
FT                   /translation="MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIP
FT                   CRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRWPLLVIAGSSSQS
FT                   DIHKGGFQELDQVSLLSPFLKFTGKLTPDNIDMITQKALNYCIQGTAGVSYIDVPADFI
FT                   EYEKPLEGNDRTGNELPMILTPNICGPDPSKIKKVVQLILQHKNKNILIVIGKGAVKNS
FT                   HEIRRLVNTFNLPFLPTPMAKGIVPDSSPLNVSSARSQALKIADIVLVLGARLNWILHF
FT                   GTSPKWNSESIFIQFDSNPETLGDNNVSPGADLSIWGDIGLSVTALVEELTRQDSCWKY
FT                   SGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDYRTILVTEGANTMDI
FT                   ARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIET
FT                   AVRCQLALVIVVMNNSGIYHGEKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISE
FT                   LSRCFQQAVQLSRTKRETSVINVIIEPGEQKQIAFAWQNKPRL"
FT   gene            complement(120498..121301)
FT                   /gene="MMS21"
FT                   /gene_synonym="NSE2"
FT                   /gene_synonym="PSO10"
FT                   /locus_tag="YEL019C"
FT   mRNA            complement(120498..121301)
FT                   /gene="MMS21"
FT                   /gene_synonym="NSE2"
FT                   /gene_synonym="PSO10"
FT                   /locus_tag="YEL019C"
FT                   /product="SUMO ligase MMS21"
FT   CDS_pept        complement(120498..121301)
FT                   /codon_start=1
FT                   /gene="MMS21"
FT                   /gene_synonym="NSE2"
FT                   /gene_synonym="PSO10"
FT                   /locus_tag="YEL019C"
FT                   /product="SUMO ligase MMS21"
FT                   /note="Highly conserved SUMO E3 ligase subunit of SMC5-SMC6
FT                   complex; required for anchoring dsDNA breaks to the nuclear
FT                   periphery; SMC5-SMC6 plays a key role in removal of
FT                   X-shaped DNA structures that arise between sister
FT                   chromatids during DNA replication and repair; required for
FT                   efficient sister chromatid cohesion; mutants are sensitive
FT                   to MMS, show increased spontaneous mutation and mitotic
FT                   recombination; SUMOylates and inhibits Snf1p function;
FT                   supports nucleolar function"
FT                   /db_xref="GOA:P38632"
FT                   /db_xref="InterPro:IPR004181"
FT                   /db_xref="InterPro:IPR013083"
FT                   /db_xref="InterPro:IPR026846"
FT                   /db_xref="PDB:3HTK"
FT                   /db_xref="UniProtKB/Swiss-Prot:P38632"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005635 nuclear
FT                   envelope [PMID:15738391]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0019789 SUMO
FT                   transferase activity [PMID:15738391]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6
FT                   complex [PMID:15738391]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA
FT                   repair [PMID:15738391|PMID:7788712]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0019789 SUMO
FT                   transferase activity [PMID:15738391|PMID:24108357]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030291 protein
FT                   serine/threonine kinase inhibitor activity [PMID:24108357]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1990683 DNA
FT                   double-strand break attachment to nuclear envelope
FT                   [PMID:27056668]"
FT                   /protein_id="DAA07634.1"
FT                   /translation="MALNDNPIPKSVPLHPKSGKYFHNLHARDLSNIYQQCYKQIDETI
FT                   NQLVDSTSPSTIGIEEQVADITSTYKLLSTYESESNSFDEHIKDLKKNFKQSSDACPQI
FT                   DLSTWDKYRTGELTAPKLSELYLNMPTPEPATMVNNTDTLKILKVLPYIWNDPTCVIPD
FT                   LQNPADEDDLQIEGGKIELTCPITCKPYEAPLISRKCNHVFDRDGIQNYLQGYTTRDCP
FT                   QAACSQVVSMRDFVRDPIMELRCKIAKMKESQEQDKRSSQAIDVL"
FT   gene            121471..122310
FT                   /gene="EAF5"
FT                   /locus_tag="YEL018W"
FT   mRNA            121471..122310
FT                   /gene="EAF5"
FT                   /locus_tag="YEL018W"
FT                   /product="Eaf5p"
FT   CDS_pept        121471..122310
FT                   /codon_start=1
FT                   /gene="EAF5"
FT                   /locus_tag="YEL018W"
FT                   /product="Eaf5p"
FT                   /note="Non-essential subunit of the NuA4 acetyltransferase
FT                   complex; Esa1p-associated factor; relocalizes to the
FT                   cytosol in response to hypoxia"
FT                   /db_xref="GOA:P39995"
FT                   /db_xref="InterPro:IPR026226"
FT                   /db_xref="PDB:5Y81"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39995"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:22932476|PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:22932476]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair
FT                   [PMID:16135807]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone
FT                   acetyltransferase complex [PMID:15485911]"
FT                   /protein_id="DAA07635.1"
FT                   /translation="MDKEVSELVVLQLIHTLISNKNEELVRNGGGINMIGNNLRISLVK
FT                   LTNEIQNNLLINELTNLRRQSNVANGNRKLGINDILTIVKNLFPEYRTTLNDGQLSLHG
FT                   LEMHDIEKLLDEKYDRFKKTQVEQIRMMEDEILKNGIKTGASQLQPHANAGKSGSAGTS
FT                   ATITTTTPHMAHSMDPKREKLLKLYRDTVLNKLESKTGNFQKLFKSPDGSIIKNEINYE
FT                   DIKNETPGSVHELQLILQKSITDGVMRKVIGTDDWKLARQVQFELDDTVQFMRRALE"
FT   gene            complement(122798..122929)
FT                   /gene="PMP2"
FT                   /locus_tag="YEL017C-A"
FT   mRNA            complement(122798..122929)
FT                   /gene="PMP2"
FT                   /locus_tag="YEL017C-A"
FT                   /product="proteolipid ATPase"
FT   CDS_pept        complement(122798..122929)
FT                   /codon_start=1
FT                   /gene="PMP2"
FT                   /locus_tag="YEL017C-A"
FT                   /product="proteolipid ATPase"
FT                   /note="Proteolipid associated with plasma membrane
FT                   H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase
FT                   activity; protein abundance increases in response to DNA
FT                   replication stress; PMP2 has a paralog, PMP1, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P40975"
FT                   /db_xref="InterPro:IPR012589"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40975"
FT                   /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
FT                   vacuole membrane [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016020 membrane
FT                   [PMID:8063750]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:26928762]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0030234
FT                   enzyme regulator activity [PMID:8063750]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0032781
FT                   positive regulation of ATPase activity [PMID:8063750]"
FT                   /protein_id="DAA07636.1"
FT                   /translation="MLMSTLPGGVILVFILVGLACIAIISTIIYRKWQARQRGLQRF"
FT   gene            123657..124670
FT                   /gene="GTT3"
FT                   /locus_tag="YEL017W"
FT   mRNA            123657..124670
FT                   /gene="GTT3"
FT                   /locus_tag="YEL017W"
FT                   /product="Gtt3p"
FT   CDS_pept        123657..124670
FT                   /codon_start=1
FT                   /gene="GTT3"
FT                   /locus_tag="YEL017W"
FT                   /product="Gtt3p"
FT                   /note="hypothetical protein may be involved in glutathione
FT                   metabolism; function suggested by computational analysis of
FT                   large-scale protein-protein interaction data; N- and
FT                   C-terminal fusion proteins localize to the cell periphery"
FT                   /db_xref="GOA:P39996"
FT                   /db_xref="InterPro:IPR038872"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39996"
FT                   /experiment="EXISTENCE:direct assay:GO:0034399 nuclear
FT                   periphery [PMID:26928762]"
FT                   /protein_id="DAA07637.1"
FT                   /translation="MPTKSTFSRWKKADLIDLANKLEIDGFPNYAKKSDMIDYLESHLN
FT                   HLEKPVDFKDDYPELRSFYESMTVDQSKDERNEYGSGSGNGSGSGSCDTATNDSDLEKA
FT                   YIKEDDDEKPQSGDETSATKPLSSRNANSNAKTNFNLLDFSTDNDSSTSAFTKFKFNFQ
FT                   EYLSDIRYQTQKLNENVQDYLSTISAVDTIFSLLEFSFLVRNILAAGQPTSSSSLASSL
FT                   EAAVAAHNKYQYTLDFCLPILTWLLFFRGIPTLVSYYINFIRYDLNIELDPMTFNLTKF
FT                   LISLAIFKTCNNKNIDFHSFRCVNQLWTQLCTVNRSLGMVPLVFSMVSCLLTLYVL"
FT   gene            complement(124737..126218)
FT                   /gene="NPP2"
FT                   /locus_tag="YEL016C"
FT   mRNA            complement(124737..126218)
FT                   /gene="NPP2"
FT                   /locus_tag="YEL016C"
FT                   /product="nucleotide diphosphatase/phosphodiesterase NPP2"
FT   CDS_pept        complement(124737..126218)
FT                   /codon_start=1
FT                   /gene="NPP2"
FT                   /locus_tag="YEL016C"
FT                   /product="nucleotide diphosphatase/phosphodiesterase NPP2"
FT                   /EC_number="3.6.1.9"
FT                   /EC_number="3.1.4.1"
FT                   /note="Nucleotide pyrophosphatase/phosphodiesterase;
FT                   mediates extracellular nucleotide phosphate hydrolysis
FT                   along with Npp1p and Pho5p; activity and expression
FT                   enhanced during conditions of phosphate starvation;
FT                   involved in spore wall assembly; SWAT-GFP and mCherry
FT                   fusion proteins localize to the endoplasmic reticulum; NPP2
FT                   has a paralog, NPP1, that arose from the whole genome
FT                   duplication; npp1 npp2 double mutant exhibits reduced
FT                   dityrosine fluorescence relative to single mutants"
FT                   /db_xref="GOA:P39997"
FT                   /db_xref="InterPro:IPR002591"
FT                   /db_xref="InterPro:IPR017850"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39997"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0047429
FT                   nucleoside-triphosphate diphosphatase activity
FT                   [PMID:16278456]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0017111
FT                   nucleoside-triphosphatase activity [PMID:16278456]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0047429
FT                   nucleoside-triphosphate diphosphatase activity
FT                   [PMID:16278456]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009141
FT                   nucleoside triphosphate metabolic process [PMID:16278456]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0017111
FT                   nucleoside-triphosphatase activity [PMID:16278456]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0047429
FT                   nucleoside-triphosphate diphosphatase activity
FT                   [PMID:16278456]"
FT                   /protein_id="DAA07638.1"
FT                   /translation="MLLFEQPVDLEKNNEDDTNIKPFAISRHFLLKLLLCGIILIELLL
FT                   YSKCPKPIDNGPRTIANRSNTYFNGTHDFKTLTILISIDGFHPRLIDAKYTPFLYNLHN
FT                   LRSPYDMNITTAPYMIPSFPTQTFPNHWSMVTGKYPIEHGIVSNIFWDNFTSSEFRPNN
FT                   LDARIWSNTADPIWQLLQTESQGEYKVATHMWPGSEVVYEDHGDVPRERMPFYFGKFNQ
FT                   WEKLQDKLAQIFRYIDMPQLKDRPELVISYIPNVDSYGHSFGYDLRDKRLQKLIGEVDG
FT                   FFLDLIEGLQKRNLLKISNVMIVSDHGMSNVNANDGEHVVVWERVFPADAMSAFISHLY
FT                   NEGPMMMVCLKNPRDKQWICDLIEAQLEKAYGDEISRKFHVILKEDFDPSWKYFQYDNR
FT                   KHRYDDRVGDIWILADEYYAIVKEMGDVPIGIMGTHGYNFNNCSDMASIFIGMGPMFNN
FT                   EVVPPFENIEVYNMLIKASALLGEEKTKKEKSLLQ"
FT   gene            126629..128284
FT                   /gene="EDC3"
FT                   /gene_synonym="DCP3"
FT                   /gene_synonym="LSM16"
FT                   /locus_tag="YEL015W"
FT   mRNA            126629..128284
FT                   /gene="EDC3"
FT                   /gene_synonym="DCP3"
FT                   /gene_synonym="LSM16"
FT                   /locus_tag="YEL015W"
FT                   /product="Edc3p"
FT   CDS_pept        126629..128284
FT                   /codon_start=1
FT                   /gene="EDC3"
FT                   /gene_synonym="DCP3"
FT                   /gene_synonym="LSM16"
FT                   /locus_tag="YEL015W"
FT                   /product="Edc3p"
FT                   /note="Non-essential conserved protein with a role in mRNA
FT                   decapping; specifically affects the function of the
FT                   decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA
FT                   via binding to both Rps28Bp (or Rps28Ap) and the RPS28B
FT                   mRNA; mediates decay of the YRA1 mRNA by a different,
FT                   translation-independent mechanism; localizes to cytoplasmic
FT                   mRNA processing bodies; forms cytoplasmic foci upon DNA
FT                   replication stress"
FT                   /db_xref="GOA:P39998"
FT                   /db_xref="InterPro:IPR004443"
FT                   /db_xref="InterPro:IPR019050"
FT                   /db_xref="InterPro:IPR025762"
FT                   /db_xref="InterPro:IPR036652"
FT                   /db_xref="PDB:4BRU"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39998"
FT                   /experiment="EXISTENCE:direct assay:GO:0000932 P-body
FT                   [PMID:15020463]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding
FT                   [PMID:24492965]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:23706738]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:23706738|PMID:22842922]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0033962
FT                   cytoplasmic mRNA processing body assembly [PMID:18981231]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031087
FT                   deadenylation-independent decapping of nuclear-transcribed
FT                   mRNA [PMID:15225544]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0033962
FT                   cytoplasmic mRNA processing body assembly
FT                   [PMID:17984320|PMID:18981231]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1900153 positive
FT                   regulation of nuclear-transcribed mRNA catabolic process,
FT                   deadenylation-dependent decay
FT                   [PMID:23956223|PMID:24492965]"
FT                   /protein_id="DAA07639.1"
FT                   /translation="MSQFVGFGVQVELKDGKLIQGKIAKATSKGLTLNDVQFGDGGKSQ
FT                   AFKVRASRLKDLKVLTVASQSGKRKQQRQQQQQNDYNQNRGEHIDWQDDDVSKIKQQED
FT                   FDFQRNLGMFNKKDVFAQLKQNDDILPENRLQGHNRKQTQLQQNNYQNDELVIPDAKKD
FT                   SWNKISSRNEQSTHQSQPQQDAQDDLVLEDDEHEYDVDDIDDPKYLPITQSLNITHLIH
FT                   SATNSPSINDKTKGTVINDKDQVLAKLGQMIISQSRSNSTSLPAANKQTTIRSKNTKQN
FT                   IPMATPVQLLEMESITSEFFSINSAGLLENFAVNASFFLKQKLGGRARLRLQNSNPEPL
FT                   VVILASDSNRSGAKALALGRHLCQTGHIRVITLFTCSQNELQDSMVKKQTDIYKKCGGK
FT                   IVNSVSSLESAMETLNSPVEIVIDAMQGYDCTLSDLAGTSEVIESRIKSMISWCNKQRG
FT                   STKVWSLDIPNGFDAGSGMPDIFFSDRIEATGIICSGWPLIAINNLIANLPSLEDAVLI
FT                   DIGIPQGAYSQRTSLRKFQNCDLFVTDGSLLLDL"
FT   gene            complement(128303..128608)
FT                   /locus_tag="YEL014C"
FT   mRNA            complement(128303..128608)
FT                   /locus_tag="YEL014C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(128303..128608)
FT                   /codon_start=1
FT                   /locus_tag="YEL014C"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; conserved among S. cerevisiae
FT                   strains"
FT                   /db_xref="GOA:P39999"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39999"
FT                   /protein_id="DAA80285.1"
FT                   /translation="MTALFCLELRTNIFLIMNDCIIINYWKGFIFSFHSYFFPFRFESS
FT                   LRAHYPGKRNYSDFSVIPLPYYIDVRSFHICESQHIIALPLQIPLPYRMLIRMYPV"
FT   gene            128825..130561
FT                   /gene="VAC8"
FT                   /gene_synonym="YEB3"
FT                   /locus_tag="YEL013W"
FT   mRNA            128825..130561
FT                   /gene="VAC8"
FT                   /gene_synonym="YEB3"
FT                   /locus_tag="YEL013W"
FT                   /product="protein anchor VAC8"
FT   CDS_pept        128825..130561
FT                   /codon_start=1
FT                   /gene="VAC8"
FT                   /gene_synonym="YEB3"
FT                   /locus_tag="YEL013W"
FT                   /product="protein anchor VAC8"
FT                   /note="Vacuolar membrane protein; vacuole-specific Myo2p
FT                   receptor and Myo2p-Vac17p-Vac8p transport complex subunit
FT                   required for vacuolar inheritance; required with Atg13p for
FT                   the vesicle closure step of the cytoplasm-to-vacuole (CVT)
FT                   pathway, for homotypic vacuole-vacuole fusion and for
FT                   nucleus-vacuole junction formation with Nvj1p; contains 11
FT                   armadillo (ARM) repeats; myristoylated, palmitoylated, and
FT                   phosphorylated"
FT                   /db_xref="GOA:P39968"
FT                   /db_xref="InterPro:IPR000225"
FT                   /db_xref="InterPro:IPR011989"
FT                   /db_xref="InterPro:IPR016024"
FT                   /db_xref="PDB:5XJG"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39968"
FT                   /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
FT                   vacuole membrane
FT                   [PMID:16301533|PMID:9490720|PMID:9664035|PMID:9739084|PMID
FT                   :26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000425 pexophagy
FT                   [PMID:31262095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006914 autophagy
FT                   [PMID:31262095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016021 integral
FT                   component of membrane [PMID:10888680]"
FT                   /experiment="EXISTENCE:direct assay:GO:0034517 ribophagy
FT                   [PMID:31262095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045121 membrane
FT                   raft [PMID:10888680]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071561
FT                   nucleus-vacuole junction [PMID:10888680]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071563
FT                   Myo2p-Vac17p-Vac8p transport complex [PMID:12529432]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole
FT                   inheritance [PMID:16301533|PMID:8885233|PMID:10888680]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016236
FT                   macroautophagy [PMID:15901835]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034727
FT                   piecemeal microautophagy of the nucleus
FT                   [PMID:12529432|PMID:18701704]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole
FT                   fusion, non-autophagic [PMID:11441010|PMID:16301533]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043495 protein
FT                   membrane anchor [PMID:12594460]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0071255 Cvt
FT                   vesicle assembly [PMID:10837477]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0071562
FT                   nucleus-vacuole junction assembly [PMID:10888680]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1903044 protein
FT                   localization to membrane raft [PMID:10888680]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0043495
FT                   protein membrane anchor [PMID:12594460]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0071561
FT                   nucleus-vacuole junction [PMID:10888680]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0071563
FT                   Myo2p-Vac17p-Vac8p transport complex
FT                   [PMID:12529432|PMID:12594460]"
FT                   /protein_id="DAA07640.1"
FT                   /translation="MGSCCSCLKDSSDEASVSPIADNEREAVTLLLGYLEDKDQLDFYS
FT                   GGPLKALTTLVYSDNLNLQRSAALAFAEITEKYVRQVSREVLEPILILLQSQDPQIQVA
FT                   ACAALGNLAVNNENKLLIVEMGGLEPLINQMMGDNVEVQCNAVGCITNLATRDDNKHKI
FT                   ATSGALIPLTKLAKSKHIRVQRNATGALLNMTHSEENRKELVNAGAVPVLVSLLSSTDP
FT                   DVQYYCTTALSNIAVDEANRKKLAQTEPRLVSKLVSLMDSPSSRVKCQATLALRNLASD
FT                   TSYQLEIVRAGGLPHLVKLIQSDSIPLVLASVACIRNISIHPLNEGLIVDAGFLKPLVR
FT                   LLDYKDSEEIQCHAVSTLRNLAASSEKNRKEFFESGAVEKCKELALDSPVSVQSEISAC
FT                   FAILALADVSKLDLLEANILDALIPMTFSQNQEVSGNAAAALANLCSRVNNYTKIIEAW
FT                   DRPNEGIRGFLIRFLKSDYATFEHIALWTILQLLESHNDKVEDLVKNDDDIINGVRKMA
FT                   DVTFERLQRSGIDVKNPGSNNNPSSNDNNSNNNDTGSEHQPVEDASLELYNITQQILQF
FT                   LH"
FT   gene            complement(131082..131153)
FT                   /locus_tag="tQ(UUG)E2"
FT   tRNA            complement(131082..131153)
FT                   /locus_tag="tQ(UUG)E2"
FT                   /product="tRNA-Gln"
FT                   /note="tQ(UUG)E2; Glutamine tRNA (tRNA-Gln), predicted by
FT                   tRNAscan-SE analysis; thiolation of uridine at wobble
FT                   position (34) requires Ncs6p"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:15706032]"
FT   gene            131772..132551
FT                   /gene="UBC8"
FT                   /gene_synonym="GID3"
FT                   /locus_tag="YEL012W"
FT   mRNA            join(131772..131776,131900..132551)
FT                   /gene="UBC8"
FT                   /gene_synonym="GID3"
FT                   /locus_tag="YEL012W"
FT                   /product="E2 ubiquitin-conjugating protein UBC8"
FT   CDS_pept        join(131772..131776,131900..132551)
FT                   /codon_start=1
FT                   /gene="UBC8"
FT                   /gene_synonym="GID3"
FT                   /locus_tag="YEL012W"
FT                   /product="E2 ubiquitin-conjugating protein UBC8"
FT                   /EC_number="2.3.2.23"
FT                   /note="Ubiquitin-conjugating enzyme that regulates
FT                   gluconeogenesis; negatively regulates gluconeogenesis by
FT                   mediating the glucose-induced ubiquitination of
FT                   fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme
FT                   that catalyzes the ubiquitination of histones in vitro"
FT                   /db_xref="GOA:P28263"
FT                   /db_xref="InterPro:IPR000608"
FT                   /db_xref="InterPro:IPR016135"
FT                   /db_xref="InterPro:IPR023313"
FT                   /db_xref="UniProtKB/Swiss-Prot:P28263"
FT                   /experiment="EXISTENCE:direct assay:GO:0004842
FT                   ubiquitin-protein transferase activity [PMID:1869573]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:10811607]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006511
FT                   ubiquitin-dependent protein catabolic process
FT                   [PMID:10811607]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043161
FT                   proteasome-mediated ubiquitin-dependent protein catabolic
FT                   process [PMID:12686616]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative
FT                   regulation of gluconeogenesis [PMID:12686616]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005515
FT                   protein binding [PMID:29519818]"
FT                   /protein_id="DAA07641.1"
FT                   /translation="MSSSKRRIETDVMKLLMSDHQVDLINDSMQEFHVKFLGPKDTPYE
FT                   NGVWRLHVELPDNYPYKSPSIGFVNKIFHPNIDIASGSICLDVINSTWSPLYDLINIVE
FT                   WMIPGLLKEPNGSDPLNNEAATLQLRDKKLYEEKIKEYIDKYATKEKYQQMFGGDNDSD
FT                   DSDSGGDLQEEDSDSDEDMDGTGVSSGDDSVDELSEDLSDIDVSDDDDYDEVANQ"
FT   gene            133120..135234
FT                   /gene="GLC3"
FT                   /gene_synonym="GHA1"
FT                   /locus_tag="YEL011W"
FT   mRNA            133120..135234
FT                   /gene="GLC3"
FT                   /gene_synonym="GHA1"
FT                   /locus_tag="YEL011W"
FT                   /product="1,4-alpha-glucan branching enzyme"
FT   CDS_pept        133120..135234
FT                   /codon_start=1
FT                   /gene="GLC3"
FT                   /gene_synonym="GHA1"
FT                   /locus_tag="YEL011W"
FT                   /product="1,4-alpha-glucan branching enzyme"
FT                   /EC_number="2.4.1.18"
FT                   /note="Glycogen branching enzyme, involved in glycogen
FT                   accumulation; green fluorescent protein (GFP)-fusion
FT                   protein localizes to the cytoplasm in a punctate pattern;
FT                   relocalizes from nucleus to cytoplasmic foci upon DNA
FT                   replication stress; glycogen accumulation defect of the
FT                   null mutant is functionally complemented by human GBE1,
FT                   which is associated with glycogen storage disease"
FT                   /db_xref="GOA:P32775"
FT                   /db_xref="InterPro:IPR004193"
FT                   /db_xref="InterPro:IPR006047"
FT                   /db_xref="InterPro:IPR006048"
FT                   /db_xref="InterPro:IPR013780"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="InterPro:IPR014756"
FT                   /db_xref="InterPro:IPR017853"
FT                   /db_xref="InterPro:IPR037439"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32775"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095|PMID:22842922]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003844
FT                   1,4-alpha-glucan branching enzyme activity [PMID:1729600]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005978 glycogen
FT                   biosynthetic process [PMID:1729600]"
FT                   /protein_id="DAA07642.1"
FT                   /translation="MYNIPDNVKGAVEFDPWLKPFADVLSERRYLADKWLYDITHATPD
FT                   GSYQSLSKFARDSYKSYGLHANPETKEITYKEWAPNAERAFLVGDFNNWDTTSHELKNK
FT                   DEFGNFTITLHPLPNGDFAIPHDSKIKVMFILPDGSKIFRLPAWITRATQPSKETSKQF
FT                   GPAYEGRFWNPENPYKFVHPRPKFSESVDSLRIYEAHVGISSPEPKITTYKEFTEKVLP
FT                   RIKYLGYDAIQLMAIMEHAYYASFGYQVTNFFAASSRFGTPEELKELIDTAHSMGILVL
FT                   LDVVHSHASKNVEDGLNMFDGSDHQYFHSISSGRGEHPLWDSRLFNYGKFEVQRFLLAN
FT                   LAFYVDVYQFDGFRFDGVTSMLYVHHGVGAGGSFSGDYNEYLSRDRSFVDHEALAYLML
FT                   ANDLVHEMLPNLAVTVAEDVSGYPTLCLPRSIGGTGFDYRLAMALPDMWIKLIKEKKDD
FT                   EWEMGSIVYTLTNRRYGEKVVAYCESHDQALVGDKTLAFWLMDAAMYTDMTVLKEPSIV
FT                   IDRGIALHKMIRLITHSLGGEAYLNFEGNEFGHPEWLDFPNVNNGDSYKYARRQFNLAD
FT                   DPLLRYQNLNEFDRSMQLCEKRHKWLNTKQAYVSLKHEGDKMIVFERNNLLFIFNFHPT
FT                   NSYSDYRVGVEKAGTYHIVLNSDRAEFGGHNRINESSEFFTTDLEWNNRKNFLQVYIPS
FT                   RVALVLALKE"
FT   gene            complement(135425..135497)
FT                   /locus_tag="tK(CUU)E1"
FT   tRNA            complement(135425..135497)
FT                   /locus_tag="tK(CUU)E1"
FT                   /product="tRNA-Lys"
FT                   /note="tK(CUU)E1; Lysine tRNA (tRNA-Lys), predicted by
FT                   tRNAscan-SE analysis; a small portion is imported into
FT                   mitochondria via interaction with mt lysyl-tRNA synthetase
FT                   Msk1p and is necessary to decode AAG codons at high
FT                   temperature, when base modification of mt-encoded tRNA-Lys
FT                   is reduced"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:8915539]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:8915539]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030533 triplet
FT                   codon-amino acid adaptor activity [PMID:17560369]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032543
FT                   mitochondrial translation [PMID:17560369]"
FT   repeat_region   complement(135612..135939)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            complement(136371..136778)
FT                   /locus_tag="YEL009C-A"
FT   mRNA            complement(136371..136778)
FT                   /locus_tag="YEL009C-A"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(136371..136778)
FT                   /codon_start=1
FT                   /locus_tag="YEL009C-A"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; conserved among S. cerevisiae
FT                   strains; overlaps ORF YEL010W"
FT                   /db_xref="GOA:A0A023PZF2"
FT                   /db_xref="UniProtKB/Swiss-Prot:A0A023PZF2"
FT                   /protein_id="DAA80286.1"
FT                   /translation="MNTLLKKYRKQRYAWLRFLLFSKIEGSLPVALRILLSLQPFCCNI
FT                   YRKYYQENKKVKSTSGNTALKIIEKLESLVSNLRLKYSQMFSLLFLHSYNCLQSLATET
FT                   FRIIKKREKNLLSLLIPGSCIEIARHFVLKE"
FT   repeat_region   137324..137639
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   repeat_region   138221..138553
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            138666..138737
FT                   /locus_tag="tR(UCU)E"
FT   tRNA            138666..138737
FT                   /locus_tag="tR(UCU)E"
FT                   /product="tRNA-Arg"
FT                   /note="tR(UCU)E; Arginine tRNA (tRNA-Arg), predicted by
FT                   tRNAscan-SE analysis; one of 11 nuclear tRNA genes
FT                   containing the tDNA-anticodon UCU (converted to mcm5-UCU in
FT                   the mature tRNA), decodes AGA codons into arginine, one of
FT                   19 nuclear tRNAs for arginine"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   gene            complement(138918..139763)
FT                   /gene="GCN4"
FT                   /gene_synonym="AAS101"
FT                   /gene_synonym="AAS3"
FT                   /gene_synonym="ARG9"
FT                   /locus_tag="YEL009C"
FT   mRNA            complement(138918..139763)
FT                   /gene="GCN4"
FT                   /gene_synonym="AAS101"
FT                   /gene_synonym="AAS3"
FT                   /gene_synonym="ARG9"
FT                   /locus_tag="YEL009C"
FT                   /product="amino acid starvation-responsive transcription
FT                   factor GCN4"
FT   CDS_pept        complement(138918..139763)
FT                   /codon_start=1
FT                   /gene="GCN4"
FT                   /gene_synonym="AAS3"
FT                   /gene_synonym="ARG9"
FT                   /gene_synonym="AAS101"
FT                   /locus_tag="YEL009C"
FT                   /product="amino acid starvation-responsive transcription
FT                   factor GCN4"
FT                   /note="bZIP transcriptional activator of amino acid
FT                   biosynthetic genes; activator responds to amino acid
FT                   starvation; expression is tightly regulated at both the
FT                   transcriptional and translational levels"
FT                   /db_xref="GOA:P03069"
FT                   /db_xref="InterPro:IPR004827"
FT                   /db_xref="PDB:1CE9"
FT                   /db_xref="PDB:1DGC"
FT                   /db_xref="PDB:1ENV"
FT                   /db_xref="PDB:1FAV"
FT                   /db_xref="PDB:1FMH"
FT                   /db_xref="PDB:1GCL"
FT                   /db_xref="PDB:1GCM"
FT                   /db_xref="PDB:1GK6"
FT                   /db_xref="PDB:1GZL"
FT                   /db_xref="PDB:1IHQ"
FT                   /db_xref="PDB:1IJ0"
FT                   /db_xref="PDB:1IJ1"
FT                   /db_xref="PDB:1IJ2"
FT                   /db_xref="PDB:1IJ3"
FT                   /db_xref="PDB:1KQL"
FT                   /db_xref="PDB:1LD4"
FT                   /db_xref="PDB:1LLM"
FT                   /db_xref="PDB:1NKN"
FT                   /db_xref="PDB:1PIQ"
FT                   /db_xref="PDB:1RB4"
FT                   /db_xref="PDB:1RB5"
FT                   /db_xref="PDB:1RB6"
FT                   /db_xref="PDB:1SWI"
FT                   /db_xref="PDB:1TMZ"
FT                   /db_xref="PDB:1UNT"
FT                   /db_xref="PDB:1UNU"
FT                   /db_xref="PDB:1UNV"
FT                   /db_xref="PDB:1UNW"
FT                   /db_xref="PDB:1UNX"
FT                   /db_xref="PDB:1UNY"
FT                   /db_xref="PDB:1UNZ"
FT                   /db_xref="PDB:1UO0"
FT                   /db_xref="PDB:1UO1"
FT                   /db_xref="PDB:1UO2"
FT                   /db_xref="PDB:1UO3"
FT                   /db_xref="PDB:1UO4"
FT                   /db_xref="PDB:1UO5"
FT                   /db_xref="PDB:1W5G"
FT                   /db_xref="PDB:1W5H"
FT                   /db_xref="PDB:1W5I"
FT                   /db_xref="PDB:1W5J"
FT                   /db_xref="PDB:1W5K"
FT                   /db_xref="PDB:1W5L"
FT                   /db_xref="PDB:1YSA"
FT                   /db_xref="PDB:1ZII"
FT                   /db_xref="PDB:1ZIJ"
FT                   /db_xref="PDB:1ZIK"
FT                   /db_xref="PDB:1ZIL"
FT                   /db_xref="PDB:1ZIM"
FT                   /db_xref="PDB:1ZTA"
FT                   /db_xref="PDB:2AHP"
FT                   /db_xref="PDB:2B1F"
FT                   /db_xref="PDB:2B22"
FT                   /db_xref="PDB:2BNI"
FT                   /db_xref="PDB:2CCE"
FT                   /db_xref="PDB:2CCF"
FT                   /db_xref="PDB:2CCN"
FT                   /db_xref="PDB:2D3E"
FT                   /db_xref="PDB:2DGC"
FT                   /db_xref="PDB:2EFR"
FT                   /db_xref="PDB:2EFS"
FT                   /db_xref="PDB:2G9J"
FT                   /db_xref="PDB:2HY6"
FT                   /db_xref="PDB:2IPZ"
FT                   /db_xref="PDB:2K8X"
FT                   /db_xref="PDB:2LPB"
FT                   /db_xref="PDB:2N9B"
FT                   /db_xref="PDB:2NRN"
FT                   /db_xref="PDB:2O7H"
FT                   /db_xref="PDB:2OVN"
FT                   /db_xref="PDB:2VKY"
FT                   /db_xref="PDB:2VNL"
FT                   /db_xref="PDB:2WG5"
FT                   /db_xref="PDB:2WG6"
FT                   /db_xref="PDB:2WPY"
FT                   /db_xref="PDB:2WPZ"
FT                   /db_xref="PDB:2WQ0"
FT                   /db_xref="PDB:2WQ1"
FT                   /db_xref="PDB:2WQ2"
FT                   /db_xref="PDB:2WQ3"
FT                   /db_xref="PDB:2YNY"
FT                   /db_xref="PDB:2YNZ"
FT                   /db_xref="PDB:2YO0"
FT                   /db_xref="PDB:2YO1"
FT                   /db_xref="PDB:2YO2"
FT                   /db_xref="PDB:2YO3"
FT                   /db_xref="PDB:2Z5H"
FT                   /db_xref="PDB:2Z5I"
FT                   /db_xref="PDB:2ZTA"
FT                   /db_xref="PDB:3AZD"
FT                   /db_xref="PDB:3BAS"
FT                   /db_xref="PDB:3BAT"
FT                   /db_xref="PDB:3CK4"
FT                   /db_xref="PDB:3CRP"
FT                   /db_xref="PDB:3G9R"
FT                   /db_xref="PDB:3GJP"
FT                   /db_xref="PDB:3I1G"
FT                   /db_xref="PDB:3I5C"
FT                   /db_xref="PDB:3K7Z"
FT                   /db_xref="PDB:3M48"
FT                   /db_xref="PDB:3P8M"
FT                   /db_xref="PDB:3ZMF"
FT                   /db_xref="PDB:4C46"
FT                   /db_xref="PDB:4DMD"
FT                   /db_xref="PDB:4G2K"
FT                   /db_xref="PDB:4HU5"
FT                   /db_xref="PDB:4HU6"
FT                   /db_xref="PDB:4NIZ"
FT                   /db_xref="PDB:4NJ0"
FT                   /db_xref="PDB:4NJ1"
FT                   /db_xref="PDB:4NJ2"
FT                   /db_xref="PDB:4OWI"
FT                   /db_xref="PDB:4TL1"
FT                   /db_xref="PDB:5APP"
FT                   /db_xref="PDB:5APQ"
FT                   /db_xref="PDB:5APS"
FT                   /db_xref="PDB:5APT"
FT                   /db_xref="PDB:5APU"
FT                   /db_xref="PDB:5APV"
FT                   /db_xref="PDB:5APW"
FT                   /db_xref="PDB:5APX"
FT                   /db_xref="PDB:5APY"
FT                   /db_xref="PDB:5APZ"
FT                   /db_xref="PDB:5IEW"
FT                   /db_xref="PDB:5IIR"
FT                   /db_xref="PDB:5IIV"
FT                   /db_xref="PDB:5KHT"
FT                   /db_xref="PDB:6E52"
FT                   /db_xref="PDB:6E95"
FT                   /db_xref="PDB:6H9M"
FT                   /db_xref="PDB:6HN4"
FT                   /db_xref="PDB:6HN5"
FT                   /db_xref="PDB:6O2E"
FT                   /db_xref="PDB:6O2F"
FT                   /db_xref="UniProtKB/Swiss-Prot:P03069"
FT                   /experiment="EXISTENCE:direct assay:GO:0001135 RNA
FT                   polymerase II transcription regulator recruiting activity
FT                   [PMID:19940160]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003682 chromatin
FT                   binding [PMID:18794364]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding
FT                   transcription factor activity [PMID:16581788]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:12455686|PMID:14648200]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043565
FT                   sequence-specific DNA binding
FT                   [PMID:2204805|PMID:3290651|PMID:3464968|PMID:3530496|PMID:
FT                   3907851|PMID:19158363]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045899 positive
FT                   regulation of RNA polymerase II transcriptional
FT                   preinitiation complex assembly [PMID:18794364]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0045899
FT                   positive regulation of RNA polymerase II transcriptional
FT                   preinitiation complex assembly [PMID:15121833]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0060261
FT                   positive regulation of transcription initiation from RNA
FT                   polymerase II promoter [PMID:1425591]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:1903833
FT                   positive regulation of cellular response to amino acid
FT                   starvation [PMID:6351059]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:15590823|PMID:26979516]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001080 nitrogen
FT                   catabolite activation of transcription from RNA polymerase
FT                   II promoter [PMID:21148207]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001135 RNA
FT                   polymerase II transcription regulator recruiting activity
FT                   [PMID:16581788|PMID:19940160]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003700
FT                   DNA-binding transcription factor activity [PMID:16581788]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive
FT                   regulation of autophagy [PMID:26649943]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010691 negative
FT                   regulation of ribosomal protein gene transcription from RNA
FT                   polymerase II promoter in response to nutrient levels
FT                   [PMID:21183953]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0036278 positive
FT                   regulation of transcription from RNA polymerase II promoter
FT                   in response to nitrogen starvation [PMID:26649943]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045899 positive
FT                   regulation of RNA polymerase II transcriptional
FT                   preinitiation complex assembly [PMID:15121833]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0060261 positive
FT                   regulation of transcription initiation from RNA polymerase
FT                   II promoter [PMID:1425591]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1903833 positive
FT                   regulation of cellular response to amino acid starvation
FT                   [PMID:6351059]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0001085 RNA
FT                   polymerase II transcription factor binding
FT                   [PMID:20308326|PMID:21183953]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0001135 RNA
FT                   polymerase II transcription regulator recruiting activity
FT                   [PMID:19940160]"
FT                   /protein_id="DAA07643.1"
FT                   /translation="MSEYQPSLFALNPMGFSPLDGSKSTNENVSASTSTAKPMVGQLIF
FT                   DKFIKTEEDPIIKQDTPSNLDFDFALPQTATAPDAKTVLPIPELDDAVVESFFSSSTDS
FT                   TPMFEYENLEDNSKEWTSLFDNDIPVTTDDVSLADKAIESTEEVSLVPSNLEVSTTSFL
FT                   PTPVLEDAKLTQTRKVKKPNSVVKKSHHVGKDDESRLDHLGVVAYNRKQRSIPLSPIVP
FT                   ESSDPAALKRARNTEAARRSRARKLQRMKQLEDKVEELLSKNYHLENEVARLKKLVGER
FT                   "
FT   gene            140512..140892
FT                   /locus_tag="YEL008W"
FT   mRNA            140512..140892
FT                   /locus_tag="YEL008W"
FT                   /product="hypothetical protein"
FT   CDS_pept        140512..140892
FT                   /codon_start=1
FT                   /locus_tag="YEL008W"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; conserved among S. cerevisiae
FT                   strains; YEL008W is not an essential gene; predicted to be
FT                   involved in metabolism"
FT                   /db_xref="GOA:P40001"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40001"
FT                   /protein_id="DAA80287.1"
FT                   /translation="MLMHFIPRRSSKAVQFNWLEIGVWRGGVYVKKGIVNARTNNSNFY
FT                   KMPVVFGIVKGMGALCVHAWGMGYGGIIDCSPVTEHGNISVLQLEYMPWICLSKIMSCS
FT                   VASRHSNVWIMDETIAPLVGCL"
FT   gene            141892..143892
FT                   /gene="MIT1"
FT                   /locus_tag="YEL007W"
FT   mRNA            141892..143892
FT                   /gene="MIT1"
FT                   /locus_tag="YEL007W"
FT                   /product="Mit1p"
FT   CDS_pept        141892..143892
FT                   /codon_start=1
FT                   /gene="MIT1"
FT                   /locus_tag="YEL007W"
FT                   /product="Mit1p"
FT                   /note="Transcriptional regulator of pseudohyphal growth;
FT                   protein with sequence similarity to S. pombe gti1+
FT                   (gluconate transport inducer 1) and C. albicans Wor1"
FT                   /db_xref="GOA:P40002"
FT                   /db_xref="InterPro:IPR018608"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40002"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /protein_id="DAA07644.1"
FT                   /translation="MDIEPTFKGYIEDEDDALLILQATLDGKLKHIPRRPYEIERPYLI
FT                   VSGSIFVFIEEISGIKRWTDGVSWSPSRISGKFLIYKELDKENAGSNANATSSGSTDSA
FT                   VITDGTSGARNNPSSSKIKLPPLKNHQFDLPPTMGHSSFESEQDTSISPSNRSNLPLKY
FT                   TGLVKKTISVKLKRPPFNSIENLHIVSYYSVKDIKQNCLVTPKASPFLKDVRPSQELIV
FT                   AMGNTTLGNVKNNSTTTGNGPNNINNKSNSSTPLNTVISTNNNSANINAAGSNQFTSAN
FT                   KNYYYKNDESSGYPITQFAPALPSTTLMYTANPPYITQSPDNTNATGMNTHVNNNNNNS
FT                   NNSSNSNNSNNNNNNNNNNNNNNNNNINNINNVNTNAGNGNNPNRFHNASFAYNTTGDF
FT                   INPQQQGQISYPFYYTTIPINNPNYYTTQPPNPVTNASTNENQGYSTSSTQHPYYGHPT
FT                   ESQSASAAAGATGTPGTAENVLPVSSMQPLLHQANNNSASSATSTAPYPVYSMNVNVPY
FT                   YNSSASAYKRAQENTTSNTNAEPSGATSTNSGTMLSNPAYANSQYTPSQVYYQGFPQYA
FT                   MASAQNPSMYQHQHQHPLPTVYPIATPQQNIMSSGHTLSTIGSDPQHHHYQQEPNDHKN
FT                   FAMGHANNNILNITNNDTMNNLNTNTSTTTQ"
FT   gene            144327..145334
FT                   /gene="YEA6"
FT                   /gene_synonym="NDT2"
FT                   /locus_tag="YEL006W"
FT   mRNA            144327..145334
FT                   /gene="YEA6"
FT                   /gene_synonym="NDT2"
FT                   /locus_tag="YEL006W"
FT                   /product="NAD+ transporter"
FT   CDS_pept        144327..145334
FT                   /codon_start=1
FT                   /gene="YEA6"
FT                   /gene_synonym="NDT2"
FT                   /locus_tag="YEL006W"
FT                   /product="NAD+ transporter"
FT                   /note="Putative mitochondrial NAD+ transporter; member of
FT                   the mitochondrial carrier subfamily (see also YIA6); has
FT                   putative human ortholog; YEA6 has a paralog, YIA6, that
FT                   arose from the whole genome duplication"
FT                   /db_xref="GOA:P39953"
FT                   /db_xref="InterPro:IPR002067"
FT                   /db_xref="InterPro:IPR018108"
FT                   /db_xref="InterPro:IPR023395"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39953"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14562095]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0035352 NAD
FT                   transmembrane transport [PMID:16291748]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0051724 NAD
FT                   transmembrane transporter activity [PMID:16291748]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0035352 NAD
FT                   transmembrane transport [PMID:16291748]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051724 NAD
FT                   transmembrane transporter activity [PMID:16291748]"
FT                   /protein_id="DAA07645.1"
FT                   /translation="MNNGDNKTTLENSKNASLANGNYAIPTKLNRLKKNADPRVAAISG
FT                   ALSGALSAMLVCPFDVAKTRLQAQGLQNMTHQSQHYKGFFGTFATIFKDEGAAGLYKGL
FT                   QPTVLGYIPTLMIYFSVYDFCRKYSVDIFPHSPFLSNASSAITAGAISTVATNPIWVVK
FT                   TRLMLQTGIGKYSTHYKGTIDTFRKIIQQEGAKALYAGLVPALLGMLNVAIQFPLYENL
FT                   KIRFGYSESTDVSTDVTSSNFQKLILASMLSKMVASTVTYPHEILRTRMQLKSDLPNTV
FT                   QRHLLPLIKITYRQEGFAGFYSGFATNLVRTVPAAVVTLVSFEYSKKYLTTFFQ"
FT   rep_origin      145678..145840
FT                   /note="ARS510; Autonomously Replicating Sequence"
FT   gene            complement(145907..146755)
FT                   /gene="VAB2"
FT                   /gene_synonym="VAB31"
FT                   /locus_tag="YEL005C"
FT   mRNA            complement(145907..146755)
FT                   /gene="VAB2"
FT                   /gene_synonym="VAB31"
FT                   /locus_tag="YEL005C"
FT                   /product="Vab2p"
FT   CDS_pept        complement(145907..146755)
FT                   /codon_start=1
FT                   /gene="VAB2"
FT                   /gene_synonym="VAB31"
FT                   /locus_tag="YEL005C"
FT                   /product="Vab2p"
FT                   /note="Subunit of the BLOC-1 complex involved in endosomal
FT                   maturation; interacts with Vps21p-GFP; has potential role
FT                   in vacuolar function, as suggested by its ability to bind
FT                   Vac8p; likely member of; Vab2p-GFP-fusion localizes to
FT                   cytoplasm in punctate pattern"
FT                   /db_xref="GOA:P40003"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40003"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031083 BLOC-1
FT                   complex [PMID:23547030]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007032 endosome
FT                   organization [PMID:23547030]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032880
FT                   regulation of protein localization [PMID:23547030]"
FT                   /protein_id="DAA07646.1"
FT                   /translation="MVADLTKGILKWKSRIEFDAVGSSSYYEELKGLPPLASHKKLTQA
FT                   AIFNSTKYELLQVKKDILSIYEVVSRDIDEERNQMQQIELQLKKSLKKVEHSYKNVLKQ
FT                   RASTNCINGNDRLLANAEKKIGSLNEELACVNDIVSDIVNNLTALNANLPKKAQLLKDD
FT                   SINVAHYPLLFDFLHKSCPKSIIATSEASIHENASPSPLLEHDELPAESINSFYGENEL
FT                   QSDSLAPLQTHDDNISSCKKILPPKFNTTSGPSIETNFENISADGLTYTKCSLKNSISL
FT                   T"
FT   gene            146951..147979
FT                   /gene="YEA4"
FT                   /locus_tag="YEL004W"
FT   mRNA            146951..147979
FT                   /gene="YEA4"
FT                   /locus_tag="YEL004W"
FT                   /product="Yea4p"
FT   CDS_pept        146951..147979
FT                   /codon_start=1
FT                   /gene="YEA4"
FT                   /locus_tag="YEL004W"
FT                   /product="Yea4p"
FT                   /note="Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc)
FT                   transporter; required for cell wall chitin synthesis;
FT                   localized to the ER"
FT                   /db_xref="GOA:P40004"
FT                   /db_xref="InterPro:IPR013657"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40004"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:10788474]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0015786
FT                   UDP-glucose transmembrane transport [PMID:18693752]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005462
FT                   UDP-N-acetylglucosamine transmembrane transporter activity
FT                   [PMID:10788474]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015786
FT                   UDP-glucose transmembrane transport [PMID:18693752]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034221
FT                   fungal-type cell wall chitin biosynthetic process
FT                   [PMID:10788474]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0055085
FT                   transmembrane transport [PMID:10788474]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1990569
FT                   UDP-N-acetylglucosamine transmembrane transport
FT                   [PMID:10788474]"
FT                   /protein_id="DAA07647.1"
FT                   /translation="MWNSLKAFALVFGGCCSNVITFETLMSNETGSINNLITFCQFLFV
FT                   TCQGLPEFLDVHQPFPYFKPLKTPLHVYVITVVLFYISSTTNNNVFKYNISIPIHIVFR
FT                   CFGTVITMFTCWLLNGRKYTKIQILSTLFLTIGAIIASLFKDADFRYQDLKLQAWKIGS
FT                   DQSVDLTFIFGICILVLSSFTSSLLSAYNERTYQKYGKHWKENIFYSHFLSLPLFLFSR
FT                   KQLIHEYRVMRKSERILCSNFGGKILVPREETLLLFNVLTQYFCVKGVNILASKTNALT
FT                   LSITLLVRKFISLLLSVRLFDNNLSYTGYIGVYLVFFGAFIYSLGSIHPRQNDKGAIKK
FT                   SK"
FT   gene            148176..148599
FT                   /gene="GIM4"
FT                   /gene_synonym="PFD2"
FT                   /locus_tag="YEL003W"
FT   mRNA            join(148176..148194,148283..148599)
FT                   /gene="GIM4"
FT                   /gene_synonym="PFD2"
FT                   /locus_tag="YEL003W"
FT                   /product="tubulin-binding prefolding complex subunit GIM4"
FT   CDS_pept        join(148176..148194,148283..148599)
FT                   /codon_start=1
FT                   /gene="GIM4"
FT                   /gene_synonym="PFD2"
FT                   /locus_tag="YEL003W"
FT                   /product="tubulin-binding prefolding complex subunit GIM4"
FT                   /note="Subunit of the heterohexameric cochaperone prefoldin
FT                   complex; complex binds specifically to cytosolic chaperonin
FT                   and transfers target proteins to it"
FT                   /db_xref="GOA:P40005"
FT                   /db_xref="InterPro:IPR002777"
FT                   /db_xref="InterPro:IPR009053"
FT                   /db_xref="InterPro:IPR027235"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40005"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:9463374]"
FT                   /experiment="EXISTENCE:direct assay:GO:0015631 tubulin
FT                   binding [PMID:9463374]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin
FT                   complex assembly [PMID:9463374]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0016272
FT                   prefoldin complex [PMID:9463374]"
FT                   /protein_id="DAA07648.1"
FT                   /translation="MEQRNNVFQAKYNEYKQILEELQTKIIELGHDKDEHTIVIKTLKD
FT                   AEPTRKCYRMIGGALVESDVQTSLPILETKKENIEGTISKMKETLIQTAKEFEKWKKDN
FT                   KIQVVKN"
FT   gene            complement(148722..150014)
FT                   /gene="WBP1"
FT                   /locus_tag="YEL002C"
FT   mRNA            complement(148722..150014)
FT                   /gene="WBP1"
FT                   /locus_tag="YEL002C"
FT                   /product="dolichyl-diphosphooligosaccharide-protein
FT                   glycotransferase"
FT   CDS_pept        complement(148722..150014)
FT                   /codon_start=1
FT                   /gene="WBP1"
FT                   /locus_tag="YEL002C"
FT                   /product="dolichyl-diphosphooligosaccharide-protein
FT                   glycotransferase"
FT                   /note="Beta subunit of the oligosaccharyl transferase
FT                   glycoprotein complex; required for N-linked glycosylation
FT                   of proteins in the endoplasmic reticulum; human homolog
FT                   DDOST can complement yeast growth defect during
FT                   down-regulation of yeast gene"
FT                   /db_xref="GOA:P33767"
FT                   /db_xref="InterPro:IPR005013"
FT                   /db_xref="PDB:4J86"
FT                   /db_xref="PDB:6C26"
FT                   /db_xref="PDB:6EZN"
FT                   /db_xref="UniProtKB/Swiss-Prot:P33767"
FT                   /experiment="EXISTENCE:direct assay:GO:0005635 nuclear
FT                   envelope [PMID:1724755]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:12860997|PMID:1724755]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008250
FT                   oligosaccharyltransferase complex [PMID:10358084]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016757 transferase
FT                   activity, transferring glycosyl groups [PMID:1600939]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004576
FT                   oligosaccharyl transferase activity [PMID:1600939]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005789
FT                   endoplasmic reticulum membrane [PMID:12974639]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0006487
FT                   protein N-linked glycosylation [PMID:9405463]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0008250
FT                   oligosaccharyltransferase complex [PMID:9405463]"
FT                   /protein_id="DAA07649.1"
FT                   /translation="MRTDWNFFFCILLQAIFVVGTQTSRTLVLYDQSTEPLEEYSVYLK
FT                   DLEQRNYKLEYLDINSTSTTVDLYDKEQRLFDNIIVFPTKGGKNLARQIPVKQLIKFFE
FT                   NEGNILCMSSPGAVPNTIRLFLNELGIYPSPKGHVIRDYFSPSSEELVVSSNHLLNKYV
FT                   YNARKSEDFVFGESSAALLENREQIVPILNAPRTSFTESKGKCNSWTSGSQGFLVVGFQ
FT                   NLNNARLVWIGSSDFLKNKNQDSNQEFAKELLKWTFNEKSVIKSVHAVHSHADGTSYDE
FT                   EPYKIKDKVIYSVGFSEWNGEEWLPHIADDIQFELRQVDPYYRLTLSPSGNDSETQYYT
FT                   TGEFILPDRHGVFTFLTDYRKIGLSFTTDKDVKAIRHLANDEYPRSWEISNSWVYISAI
FT                   CGVIVAWIFFVVSFVTTSSVGKKLETFKKTN"
FT   gene            complement(150301..150978)
FT                   /gene="IRC22"
FT                   /locus_tag="YEL001C"
FT   mRNA            complement(150301..150978)
FT                   /gene="IRC22"
FT                   /locus_tag="YEL001C"
FT                   /product="Irc22p"
FT   CDS_pept        complement(150301..150978)
FT                   /codon_start=1
FT                   /gene="IRC22"
FT                   /locus_tag="YEL001C"
FT                   /product="Irc22p"
FT                   /note="hypothetical protein; green fluorescent protein
FT                   (GFP)-fusion localizes to the ER; YEL001C is non-essential;
FT                   null mutant displays increased levels of spontaneous Rad52p
FT                   foci"
FT                   /db_xref="GOA:P40006"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40006"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:14562095|PMID:22842922|PMID:26928762]"
FT                   /protein_id="DAA07650.1"
FT                   /translation="MRFSMLIGFNLLTALSSFCAAISANNSDNVEHEQEVAEAVAPPSI
FT                   NIEVKYDVVGKESENHDSFLEFYAEDTATLAYNVTNWEDTNITIFGVNGTIVTYPHGYP
FT                   VADITGASIGPYEMEVNGTSKFGQDVTLNLPEGQYFLIPFLLASRFDEIVRIAAPPTLF
FT                   EIVSPPISFFNPQFLSVQVIFLAIIGGVSYYYMKSKTNQRPSKKSATVKKVDESWLPET
FT                   YKK"
FT   centromere      151987..152104
FT                   /note="CEN5; Chromosome V centromere"
FT   centromere      151987..151996
FT                   /note="CEN5_CDEI of CEN5"
FT   centromere      151997..152079
FT                   /note="CEN5_CDEII of CEN5"
FT   centromere      152080..152104
FT                   /note="CEN5_CDEIII of CEN5"
FT   gene            153520..155808
FT                   /gene="MNN1"
FT                   /locus_tag="YER001W"
FT   mRNA            153520..155808
FT                   /gene="MNN1"
FT                   /locus_tag="YER001W"
FT                   /product="alpha-1,3-mannosyltransferase MNN1"
FT   CDS_pept        153520..155808
FT                   /codon_start=1
FT                   /gene="MNN1"
FT                   /locus_tag="YER001W"
FT                   /product="alpha-1,3-mannosyltransferase MNN1"
FT                   /note="Alpha-1,3-mannosyltransferase; integral membrane
FT                   glycoprotein of the Golgi complex, required for addition of
FT                   alpha1,3-mannose linkages to N-linked and O-linked
FT                   oligosaccharides, one of five S. cerevisiae proteins of the
FT                   MNN1 family"
FT                   /db_xref="GOA:P39106"
FT                   /db_xref="InterPro:IPR022751"
FT                   /db_xref="InterPro:IPR029044"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39106"
FT                   /experiment="EXISTENCE:direct assay:GO:0005794 Golgi
FT                   apparatus [PMID:7962051]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006493 protein
FT                   O-linked glycosylation [PMID:7962051]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000033
FT                   alpha-1,3-mannosyltransferase activity [PMID:8146181]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006491 N-glycan
FT                   processing [PMID:8146181]"
FT                   /protein_id="DAA07651.1"
FT                   /translation="MLALRRFILNQRSLRSCTIPILVGALIIILVLFQLVTHRNDALIR
FT                   SSNVNSTNKKTLKDADPKVLIEAFGSPEVDPVDTIPVSPLELVPFYDQSIDTKRSSSWL
FT                   INKKGYYKHFNELSLTDRCKFYFRTLYTLDDEWTNSVKKLEYSINDNEGVDEGKDANGN
FT                   PMDEKSERLYRRKYDMFQAFERIRAYDRCFMQANPVNIQEIFPKSDKMSKERVQSKLIK
FT                   TLNATFPNYDPDNFKKYDQFEFEHKMFPFINNFTTETFHEMVPKITSPFGKVLEQGFLP
FT                   KFDHKTGKVQEYFKYEYDPSKTFWANWRDMSAKVAGRGIVLSLGSNQFPLAVKFIASLR
FT                   FEGNTLPIQVVYRGDELSQELVDKLIYAARSPDFKPVENNYDNSTNVPQEIWFLDVSNT
FT                   IHPKWRGDFGSYKSKWLVVLLNLLQEFVFLDIDAISYEKIDNYFKTTEYQKTGTVFYRE
FT                   RALRENVNERCIARYETLLPRNLESKNFQNSLLIDPDHALNECDNTLTTEEYIFKAFFH
FT                   HRRQHQLEAGLFAVDKSKHTIPLVLAAMIHLAKNTAHCTHGDKENFWLGFLAAGHTYAL
FT                   QGVYSGAIGDYVKKTDLNGKRQEAAVEICSGQIAHMSTDKKTLLWVNGGGTFCKHDNAA
FT                   KDDWKKDGDFKKFKDQFKTFEEMEKYYYITPISSKYVILPDPKSDDWHRASAGACGGYI
FT                   WCATHKTLLKPYSYNHRTTHGELITLDEEQRLHIDAVNTVWSHANKDNTRSFTEEEIKE
FT                   LENSRHEQS"
FT   gene            156803..157498
FT                   /gene="NOP16"
FT                   /locus_tag="YER002W"
FT   mRNA            156803..157498
FT                   /gene="NOP16"
FT                   /locus_tag="YER002W"
FT                   /product="Nop16p"
FT   CDS_pept        156803..157498
FT                   /codon_start=1
FT                   /gene="NOP16"
FT                   /locus_tag="YER002W"
FT                   /product="Nop16p"
FT                   /note="Constituent of 66S pre-ribosomal particles; involved
FT                   in 60S ribosomal subunit biogenesis"
FT                   /db_xref="GOA:P40007"
FT                   /db_xref="InterPro:IPR019002"
FT                   /db_xref="PDB:6C0F"
FT                   /db_xref="PDB:6CB1"
FT                   /db_xref="PDB:6ELZ"
FT                   /db_xref="PDB:6EM1"
FT                   /db_xref="PDB:6EM3"
FT                   /db_xref="PDB:6EM4"
FT                   /db_xref="PDB:6EM5"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40007"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:10684247|PMID:11914276]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:10684247]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030687 preribosome,
FT                   large subunit precursor [PMID:11583614|PMID:17443350]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042273
FT                   ribosomal large subunit biogenesis [PMID:11583614]"
FT                   /protein_id="DAA07652.1"
FT                   /translation="MTSVRKRKMNRSSVGKATRRNKDKQRKINIQSNPIIAANWDYSLT
FT                   MAQNYKKLGLRAKLQTPAGGKEADLSKVVKRIPLTKPVLDEDEDEDEGEDEQNDYNAAT
FT                   VELDENEIPEGGARIQRDKNGDVVRVVYGKKKNFDADEDVNEIKARDTTEETEVVKKLE
FT                   ELASRPVIRKERSQSEREEEWLEKLYKKHGDDYKKMFFDKKLNIYQQSEGDLKRRLLRW
FT                   KKRNGIASK"
FT   gene            complement(157736..159118)
FT                   /gene="PMI40"
FT                   /locus_tag="YER003C"
FT   mRNA            complement(join(157736..158994,159088..159118))
FT                   /gene="PMI40"
FT                   /locus_tag="YER003C"
FT                   /product="mannose-6-phosphate isomerase PMI40"
FT   CDS_pept        complement(join(157736..158994,159088..159118))
FT                   /codon_start=1
FT                   /gene="PMI40"
FT                   /locus_tag="YER003C"
FT                   /product="mannose-6-phosphate isomerase PMI40"
FT                   /EC_number="5.3.1.8"
FT                   /note="Mannose-6-phosphate isomerase; catalyzes the
FT                   interconversion of fructose-6-P and mannose-6-P; required
FT                   for early steps in protein mannosylation"
FT                   /db_xref="GOA:P29952"
FT                   /db_xref="InterPro:IPR001250"
FT                   /db_xref="InterPro:IPR011051"
FT                   /db_xref="InterPro:IPR014710"
FT                   /db_xref="InterPro:IPR016305"
FT                   /db_xref="InterPro:IPR018050"
FT                   /db_xref="UniProtKB/Swiss-Prot:P29952"
FT                   /experiment="EXISTENCE:direct assay:GO:0004476
FT                   mannose-6-phosphate isomerase activity [PMID:8011630]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell
FT                   wall mannoprotein biosynthetic process [PMID:1377774]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein
FT                   glycosylation [PMID:1377774]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009298
FT                   GDP-mannose biosynthetic process [PMID:1377774]"
FT                   /protein_id="DAA07653.1"
FT                   /translation="MSNKLFRLDAGYQQYDWGKIGSSSAVAQFAAHSDPSVQIEQDKPY
FT                   AELWMGTHSKMPSYNHESKESLRDIISKNPSAMLGKDIIDKFHATNELPFLFKVLSIEK
FT                   VLSIQAHPDKALGKILHAQDPKNYPDDNHKPEMAIAVTDFEGFCGFKPLQEIADELKRI
FT                   PELRNIVGEETSRNFIENIQPSAQKGSPEDEQNKKLLQAVFSRVMNASDDKIKIQARSL
FT                   VERSKNSPSDFNKPDLPELIQRLNKQFPDDVGLFCGCLLLNHCRLNAGEAIFLRAKDPH
FT                   AYISGDIMECMAASDNVVRAGFTPKFKDVKNLVSMLTYTYDPVEKQKMQPLKFDRSSGN
FT                   GKSVLYNPPIEEFAVLETTFDEKLGQRHFEGVDGPSILITTKGNGYIKADGQKLKAEPG
FT                   FVFFIAPHLPVDLEAEDEAFTTYRAFVEPN"
FT   gene            159580..160275
FT                   /gene="FMP52"
FT                   /locus_tag="YER004W"
FT   mRNA            159580..160275
FT                   /gene="FMP52"
FT                   /locus_tag="YER004W"
FT                   /product="Fmp52p"
FT   CDS_pept        159580..160275
FT                   /codon_start=1
FT                   /gene="FMP52"
FT                   /locus_tag="YER004W"
FT                   /product="Fmp52p"
FT                   /note="hypothetical protein; localized to the mitochondrial
FT                   outer membrane; induced by treatment with 8-methoxypsoralen
FT                   and UVA irradiation"
FT                   /db_xref="GOA:P40008"
FT                   /db_xref="InterPro:IPR014843"
FT                   /db_xref="InterPro:IPR036291"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40008"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005741
FT                   mitochondrial outer membrane [PMID:16407407]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:14562095]"
FT                   /protein_id="DAA07654.1"
FT                   /translation="MNGLVLGATGLCGGGFLRHAQEAPQFSKVYAILRRELPFPATDKV
FT                   VAIVERDNSKWSQLITNEMNPQVLFTALATTRAAAGGLDKQYKIDHDLNLQLAQAAKEK
FT                   GCETIVLVSSAGAHPDSRFGYMKMKGEIERDVIALDFKHIIILRPGPLLGERTNSKQSG
FT                   FGGNLTAALGTRVYRSRFQRLLGYPVYGDEVGKVGVHLALNTSGKDKVQFVSSKDILDI
FT                   SASLEKIAT"
FT   gene            160550..162442
FT                   /gene="YND1"
FT                   /gene_synonym="APY1"
FT                   /gene_synonym="YEJ5"
FT                   /locus_tag="YER005W"
FT   mRNA            160550..162442
FT                   /gene="YND1"
FT                   /gene_synonym="APY1"
FT                   /gene_synonym="YEJ5"
FT                   /locus_tag="YER005W"
FT                   /product="apyrase"
FT   CDS_pept        160550..162442
FT                   /codon_start=1
FT                   /gene="YND1"
FT                   /gene_synonym="YEJ5"
FT                   /gene_synonym="APY1"
FT                   /locus_tag="YER005W"
FT                   /product="apyrase"
FT                   /EC_number="3.6.1.5"
FT                   /note="Apyrase with wide substrate specificity; helps
FT                   prevent inhibition of glycosylation by hydrolyzing
FT                   nucleoside tri- and diphosphates that inhibit
FT                   glycotransferases; partially redundant with Gda1p; mediates
FT                   adenovirus E4orf4-induced toxicity"
FT                   /db_xref="GOA:P40009"
FT                   /db_xref="InterPro:IPR000407"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40009"
FT                   /experiment="EXISTENCE:direct assay:GO:0000139 Golgi
FT                   membrane [PMID:10551827]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005794 Golgi
FT                   apparatus [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016020 membrane
FT                   [PMID:10409709]"
FT                   /experiment="EXISTENCE:direct assay:GO:0017110
FT                   nucleoside-diphosphatase activity [PMID:10409709]"
FT                   /experiment="EXISTENCE:direct assay:GO:0017111
FT                   nucleoside-triphosphatase activity [PMID:10409709]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030137 COPI-coated
FT                   vesicle [PMID:14562095]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein
FT                   glycosylation [PMID:10409709]"
FT                   /protein_id="DAA07655.1"
FT                   /translation="MLIENTNDRFGIVIDAGSSGSRIHVFKWQDTESLLHATNQDSQSI
FT                   LQSVPHIHQEKDWTFKLNPGLSSFEKKPQDAYKSHIKPLLDFAKNIIPESHWSSCPVFI
FT                   QATAGMRLLPQDIQSSILDGLCQGLKHPAEFLVEDCSAQIQVIDGETEGLYGWLGLNYL
FT                   YGHFNDYNPEVSDHFTFGFMDMGGASTQIAFAPHDSGEIARHRDDIATIFLRSVNGDLQ
FT                   KWDVFVSTWLGFGANQARRRYLAQLINTLPENTNDYENDDFSTRNLNDPCMPRGSSTDF
FT                   EFKDTIFHIAGSGNYEQCTKSIYPLLLKNMPCDDEPCLFNGVHAPRIDFANDKFIGTSE
FT                   YWYTANDVFKLGGEYNFDKFSKSLREFCNSNWTQILANSDKGVYNSIPENFLKDACFKG
FT                   NWVLNILHEGFDMPRIDVDAENVNDRPLFQSVEKVEERELSWTLGRILLYASGSILAGN
FT                   DDFMVGIAPSERRTKLTGKKFIPGKLLESDQLRKQSSSLSNKGFLMWFAIICCIFYLIF
FT                   HRSHIIRRRFSGLYNITKDFKTGIRRRLKFLRRSDPFSRLEEGELGTDVDGFKDVYRMK
FT                   SSSMFDLGKSSATMQREHEPQRTASQSANLAPSNLRPAFSMADFSKFKDSRLYD"
FT   gene            162723..164285
FT                   /gene="NUG1"
FT                   /locus_tag="YER006W"
FT   mRNA            162723..164285
FT                   /gene="NUG1"
FT                   /locus_tag="YER006W"
FT                   /product="RNA-binding GTPase NUG1"
FT   CDS_pept        162723..164285
FT                   /codon_start=1
FT                   /gene="NUG1"
FT                   /locus_tag="YER006W"
FT                   /product="RNA-binding GTPase NUG1"
FT                   /note="GTPase that associates with nuclear 60S
FT                   pre-ribosomes; required for export of 60S ribosomal
FT                   subunits from the nucleus"
FT                   /db_xref="GOA:P40010"
FT                   /db_xref="InterPro:IPR006073"
FT                   /db_xref="InterPro:IPR014813"
FT                   /db_xref="InterPro:IPR023179"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR030378"
FT                   /db_xref="PDB:3JCT"
FT                   /db_xref="PDB:6ELZ"
FT                   /db_xref="PDB:6EM1"
FT                   /db_xref="PDB:6EM5"
FT                   /db_xref="PDB:6FT6"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40010"
FT                   /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
FT                   [PMID:16803892]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding
FT                   [PMID:23222640]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003924 GTPase
FT                   activity [PMID:16803892]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:10684247|PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:10684247|PMID:16803892]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000055
FT                   ribosomal large subunit export from nucleus
FT                   [PMID:11583615]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0030687
FT                   preribosome, large subunit precursor [PMID:16803892]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000055
FT                   ribosomal large subunit export from nucleus
FT                   [PMID:11583615]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000463
FT                   maturation of LSU-rRNA from tricistronic rRNA transcript
FT                   (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12089522]"
FT                   /protein_id="DAA07656.1"
FT                   /translation="MRVRKRQSRRTSTKLKEGIKKKASAHRKKEKKMAKKDVTWRSRSK
FT                   KDPGIPSNFPYKAKILEEIEAKKMKDLEERELAKQQRLEARKAAKEQGVDAMDEDMIED
FT                   DENGLAALVESAQQAAAEYEGTPSNDADVRDDELDVIDYNIDFYGEDVEGESELEKSRK
FT                   AYDKIFKSVIDASDVILYVLDARDPESTRSRKVEEAVLQSQGKRLILILNKVDLIPPHV
FT                   LEQWLNYLKSSFPTIPLRASSGAVNGTSFNRKLSQTTTASALLESLKTYSNNSNLKRSI
FT                   VVGVIGYPNVGKSSVINALLARRGGQSKACPVGNEAGVTTSLREIKIDNKLKILDSPGI
FT                   CFPSENKKRSKVEHEAELALLNALPAKHIVDPYPAVLMLVKRLAKSDEMTESFKKLYEI
FT                   PPIPANDADTFTKHFLIHVARKRGRLGKGGIPNLASAGLSVLNDWRDGKILGWVLPNTS
FT                   AAASQQDKQNLSTINTGTKQAPIAANESTIVSEWSKEFDLDGLFSSLDKAIDASKDQDT
FT                   MME"
FT   gene            164527..166083
FT                   /gene="PAC2"
FT                   /locus_tag="YER007W"
FT   mRNA            164527..166083
FT                   /gene="PAC2"
FT                   /locus_tag="YER007W"
FT                   /product="Pac2p"
FT   CDS_pept        164527..166083
FT                   /codon_start=1
FT                   /gene="PAC2"
FT                   /locus_tag="YER007W"
FT                   /product="Pac2p"
FT                   /note="Microtubule effector required for tubulin
FT                   heterodimer formation; binds alpha-tubulin, required for
FT                   normal microtubule function, null mutant exhibits
FT                   cold-sensitive microtubules and sensitivity to benomyl"
FT                   /db_xref="GOA:P39937"
FT                   /db_xref="InterPro:IPR000938"
FT                   /db_xref="InterPro:IPR001611"
FT                   /db_xref="InterPro:IPR029071"
FT                   /db_xref="InterPro:IPR032675"
FT                   /db_xref="InterPro:IPR036859"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39937"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006457
FT                   protein folding [PMID:9215891]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007021
FT                   tubulin complex assembly [PMID:9215891]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin
FT                   complex assembly [PMID:9215891]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0043014
FT                   alpha-tubulin binding [PMID:9885248]"
FT                   /protein_id="DAA07657.1"
FT                   /translation="MTYEIGDRLKIGGYFCTIKFIGVIKPWPSVKAYGVEWDDHSRGKH
FT                   SGTIDDIHYFDVQIPNSGSFLKESKIKSPGVRRITFYEALSEKYGGSSNNINDLSIGNK
FT                   RVEGLGFDELNARNKNYKKLRKIALRDSDVAILFQNQDELNRVIQNCVNVKDLDLSLNL
FT                   FTNINSLCEFIEPLKNLESLNISQNKLLSGWDNLKEYDLSHIKTLRLSSCGLSYKHIGK
FT                   LLKSFRTLKMLDLSYNNLTSAGIQNFENEIPCTLEELNISGNNLISFPLFPKNLTLKGL
FT                   NVSNNQISRAPSIAIYSVESLDITDNKFKERSLIDDLNKTFPSLKNIHLSGNEFNYNGN
FT                   YINVEEQATFYEVLARFDRVMVLNGSICDVKTRREAEMFFVSKVMNNELSYDTNLPRWS
FT                   SLIKSYEIDMSKLSFNNERETRQSLVLKIKIRAGKKPSSDLDYWVLPSFTVRYVKSVIC
FT                   RKLNFDILNVKLFHENSEGMINEIKYNFRPISDFNVVNGDIIHVSSPVNNKSIQKVNSP
FT                   S"
FT   gene            complement(166237..166885)
FT                   /gene="TMA20"
FT                   /locus_tag="YER007C-A"
FT   mRNA            complement(join(166237..166771,166875..166885))
FT                   /gene="TMA20"
FT                   /locus_tag="YER007C-A"
FT                   /product="Tma20p"
FT   CDS_pept        complement(join(166237..166771,166875..166885))
FT                   /codon_start=1
FT                   /gene="TMA20"
FT                   /locus_tag="YER007C-A"
FT                   /product="Tma20p"
FT                   /note="hypothetical protein that associates with ribosomes;
FT                   has a putative RNA binding domain; interacts with Tma22p;
FT                   null mutant exhibits translation defects; has homology to
FT                   human oncogene MCT-1; protein abundance increases in
FT                   response to DNA replication stress"
FT                   /db_xref="GOA:P89886"
FT                   /db_xref="InterPro:IPR002478"
FT                   /db_xref="InterPro:IPR004521"
FT                   /db_xref="InterPro:IPR015947"
FT                   /db_xref="InterPro:IPR016437"
FT                   /db_xref="InterPro:IPR036974"
FT                   /db_xref="InterPro:IPR041366"
FT                   /db_xref="UniProtKB/Swiss-Prot:P89886"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:23613772]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome
FT                   biogenesis [PMID:16702403]"
FT                   /protein_id="DAA07658.1"
FT                   /translation="MFKKFTREDVHSRSKVKSSIQRTLKAKLVKQYPKIEDVIDELIPK
FT                   KSQIELIKCEDKIQLYSVDGEVLFFQKFDELIPSLKLVHKFPEAYPTVQVDRGAIKFVL
FT                   SGANIMCPGLTSAGADLPPAPGYEKGTIVVINAENKENALAIGELMMGTEEIKSVNKGH
FT                   SIELIHHLGDPLWNFSVE"
FT   gene            complement(167427..167586)
FT                   /locus_tag="snR14"
FT   ncRNA           complement(167427..167586)
FT                   /locus_tag="snR14"
FT                   /product="SNR14"
FT                   /note="U4 spliceosomal RNA (U4 snRNA); interacts with U6"
FT                   /experiment="EXISTENCE:direct assay:GO:0005681 spliceosomal
FT                   complex [PMID:2962902]"
FT                   /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5
FT                   tri-snRNP complex [PMID:10377396|PMID:10449419]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0017069
FT                   snRNA binding [PMID:2440583]"
FT                   /ncRNA_class="snRNA"
FT   gene            complement(167808..171818)
FT                   /gene="SEC3"
FT                   /gene_synonym="PSL1"
FT                   /locus_tag="YER008C"
FT   mRNA            complement(167808..171818)
FT                   /gene="SEC3"
FT                   /gene_synonym="PSL1"
FT                   /locus_tag="YER008C"
FT                   /product="GTP-Rho binding exocyst subunit SEC3"
FT   CDS_pept        complement(167808..171818)
FT                   /codon_start=1
FT                   /gene="SEC3"
FT                   /gene_synonym="PSL1"
FT                   /locus_tag="YER008C"
FT                   /product="GTP-Rho binding exocyst subunit SEC3"
FT                   /note="Subunit of the exocyst complex; the exocyst mediates
FT                   polarized targeting and tethering of post-Golgi secretory
FT                   vesicles to sites of exocytosis prior to SNARE-mediated
FT                   fusion; PtdIns[4,5]P2-binding protein that localizes to
FT                   exocytic sites in a Rho1p-dependent, actin-independent
FT                   manner, targeting and anchoring the exocyst to the plasma
FT                   membrane with Exo70p; direct GTP Rho1p effector; required
FT                   for ER inheritance; relocalizes away from bud neck upon DNA
FT                   replication stress"
FT                   /db_xref="GOA:P33332"
FT                   /db_xref="InterPro:IPR019160"
FT                   /db_xref="InterPro:IPR028258"
FT                   /db_xref="PDB:3A58"
FT                   /db_xref="PDB:3HIE"
FT                   /db_xref="PDB:5LG4"
FT                   /db_xref="PDB:5M4Y"
FT                   /db_xref="PDB:5YFP"
FT                   /db_xref="UniProtKB/Swiss-Prot:P33332"
FT                   /experiment="EXISTENCE:curator inference:GO:0090522 vesicle
FT                   tethering involved in exocytosis [PMID:8978675]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000131 incipient
FT                   cellular bud site [PMID:11595741|PMID:9491896]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000145 exocyst
FT                   [PMID:8978675]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005546
FT                   phosphatidylinositol-4,5-bisphosphate binding
FT                   [PMID:18195105]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005628 prospore
FT                   membrane [PMID:24390141]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud
FT                   tip
FT                   [PMID:11595741|PMID:17717527|PMID:9491896|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud
FT                   neck
FT                   [PMID:11595741|PMID:9491896|PMID:22842922|PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006887 exocytosis
FT                   [PMID:15772160]"
FT                   /experiment="EXISTENCE:direct assay:GO:0017049 GTP-Rho
FT                   binding [PMID:11283608]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043332 mating
FT                   projection tip [PMID:9491896|PMID:19053807]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006887
FT                   exocytosis [PMID:12913108|PMID:17717527]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi
FT                   to plasma membrane transport [PMID:7026045]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0048309
FT                   endoplasmic reticulum inheritance [PMID:15583030]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0051601
FT                   exocyst localization [PMID:17717527|PMID:18946089]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001927 exocyst
FT                   assembly [PMID:15583030]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006887
FT                   exocytosis [PMID:6996832]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to
FT                   plasma membrane transport [PMID:7026045]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0048309
FT                   endoplasmic reticulum inheritance
FT                   [PMID:12960429|PMID:15583030]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0017049
FT                   GTP-Rho binding [PMID:11595741]"
FT                   /protein_id="DAA07659.1"
FT                   /translation="MRSSKSPFKRKSHSRETSHDENTSFFHKRTISGSSAHHSRNVSQG
FT                   AVPSSAPPVSGGNYSHKRNVSRASNSSQTSNFLAEQYERDRKAIINCCFSRPDHKTGEP
FT                   PNNYITHVRIIEDSKFPSSRPPPDSKLENKKKRLLILSAKPNNAKLIQIHKARENSDGS
FT                   FQIGRTWQLTELVRVEKDLEISEGFILTMSKKYYWETNSAKERTVFIKSLITLYIQTFE
FT                   GHVPELVNWDLSLFYLDERSYQRAVITNRPGSVSPIKSPTSNFTTNTTQSVGSVPFSAP
FT                   TERTRRSETESVNPVSTPASVEYHAGMKSLNKAPYSSNSTLNEVNKRYELEQQQQQEEA
FT                   ELRRLEEQKRLQLQKENEMKRLEEERRIKQEERKRQMELEHQRQLEEEERKRQMELEAK
FT                   KQMELKRQRQFEEEQRLKKERELLEIQRKQREQETAERLKKEEQEALAKKEEEEKSKRN
FT                   KVDNESYTQEINGKVDNLLEDLNAVLAEETETTPTMQNGTYVPERSTARAHDQLKKPLN
FT                   IAKVESLGGSDLNDSISLSDEIAGLNTSNLSGEDQDEKNDLSFEKGDEVRYSNNFEGEA
FT                   PHVYHEVSIIQEEAPAVSQKLILPEENNESEALIESKEEIKTMENIDDEVLLEILTDIN
FT                   WSIEDDADSMIERIDLRLAETEYLFNQNLLSLQKIGPNIRPYEDKVNDECHRIIPTLSL
FT                   FLMEMSNFSNDIENVESQDNGLQVESANKKLLWNTLDELLKTVSLDEISLNQLLECPIR
FT                   EKNLPWMENQLNLLLKAFQAIGSDGNEVEYNLREISGLKQRLQFYEKVTKIFLNRIVEE
FT                   MQKKFSNIRGQDISHDQMIRILTTLLIFSPLILFCKEISQKSYQAIVENWNVSIQPVYM
FT                   ELWTKKISQLQGIDTNDEKMNELSLSQLLNEWDTFRKERKTNDINPVFKNSFSLLTECL
FT                   QTMRQECIVYQNFVEVFFHISSKHNFEEYIKHFNDPDAPPILLDTVKVMQSDREAAVIE
FT                   TQLVSRIFQPIVTRLSSYFVELVKAEPTVAPALTFYLENEIKSLESSNHEFLLSAVTRM
FT                   YTQIKQVWSDNVEEQVLHFERISNATTNGEILPGILDLPVGLKNSEDLFQFAKRSMDIK
FT                   DTDEGYESIELMNSSFRKLSIAATRSITHKEVNSSINPNLSDTAALNNDYMETISLLVN
FT                   SNWLTEMLSMLNFNKDGIFDTSLQNVKKVFDVEKESYASFLLRDTMPKLTAFVYGVSNI
FT                   IENTNNVNMTNPSRWAAYSRQNLENILLAYTSHEIETLVKRLHTHMVNDFGYHQENAIN
FT                   NVLCDKLWSCIQGQTVSLYLKLYTVIDKHYRGTNIRFTKNDIISAFEEYKNA"
FT   gene            172115..172492
FT                   /gene="NTF2"
FT                   /locus_tag="YER009W"
FT   mRNA            172115..172492
FT                   /gene="NTF2"
FT                   /locus_tag="YER009W"
FT                   /product="Ran GTPase-binding protein NTF2"
FT   CDS_pept        172115..172492
FT                   /codon_start=1
FT                   /gene="NTF2"
FT                   /locus_tag="YER009W"
FT                   /product="Ran GTPase-binding protein NTF2"
FT                   /note="Nuclear envelope protein; interacts with GDP-bound
FT                   Gsp1p and with proteins of the nuclear pore to transport
FT                   Gsp1p into the nucleus where it is an essential player in
FT                   nucleocytoplasmic transport"
FT                   /db_xref="GOA:P33331"
FT                   /db_xref="InterPro:IPR002075"
FT                   /db_xref="InterPro:IPR018222"
FT                   /db_xref="InterPro:IPR032710"
FT                   /db_xref="PDB:1GY7"
FT                   /db_xref="PDB:1GYB"
FT                   /db_xref="UniProtKB/Swiss-Prot:P33331"
FT                   /experiment="EXISTENCE:direct assay:GO:0005635 nuclear
FT                   envelope [PMID:8702493]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008536 Ran GTPase
FT                   binding [PMID:10889207]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein
FT                   import into nucleus [PMID:8702493|PMID:11024003]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006913
FT                   nucleocytoplasmic transport [PMID:8702493]"
FT                   /protein_id="DAA07660.1"
FT                   /translation="MSLDFNTLAQNFTQFYYNQFDTDRSQLGNLYRNESMLTFETSQLQ
FT                   GAKDIVEKLVSLPFQKVQHRITTLDAQPASPNGDVLVMITGDLLIDEEQNPQRFSQVFH
FT                   LIPDGNSYYVFNDIFRLNYSA"
FT   gene            complement(172634..173338)
FT                   /locus_tag="YER010C"
FT   mRNA            complement(172634..173338)
FT                   /locus_tag="YER010C"
FT                   /product="bifunctional 4-hydroxy-4-methyl-2-oxoglutarate
FT                   aldolase/oxaloacetate decarboxylase"
FT   CDS_pept        complement(172634..173338)
FT                   /codon_start=1
FT                   /locus_tag="YER010C"
FT                   /product="bifunctional 4-hydroxy-4-methyl-2-oxoglutarate
FT                   aldolase/oxaloacetate decarboxylase"
FT                   /EC_number="4.1.3.17"
FT                   /EC_number="4.1.1.112"
FT                   /note="Bifunctional HMG aldolase/oxaloacetate
FT                   decarboxylase; requires divalent metal ions for activity;
FT                   competitively inhibited by oxalate; forms a ring-shaped
FT                   homotrimer; similar to members of the prokaryotic RraA
FT                   family of class II (divalent metal ion dependent) pyruvate
FT                   aldolases from the meta cleavage pathways of
FT                   protocatechuate and gallate"
FT                   /db_xref="GOA:P40011"
FT                   /db_xref="InterPro:IPR005493"
FT                   /db_xref="InterPro:IPR036704"
FT                   /db_xref="PDB:2C5Q"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40011"
FT                   /experiment="EXISTENCE:direct assay:GO:0008948 oxaloacetate
FT                   decarboxylase activity [PMID:24359411]"
FT                   /experiment="EXISTENCE:direct assay:GO:0019619
FT                   3,4-dihydroxybenzoate catabolic process [PMID:24359411]"
FT                   /experiment="EXISTENCE:direct assay:GO:0047443
FT                   4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
FT                   [PMID:24359411]"
FT                   /protein_id="DAA07661.1"
FT                   /translation="MSDLQKLQRFSTCDISDGLLNVYNIPTGGYFPNLTAISPPQNSSI
FT                   VGTAYTVLFAPIDDPRPAVNYIDSVPPNSILVLALEPHLQSQFHPFIKITQAMYGGLMS
FT                   TRAQYLKSNGTVVFGRIRDVDEHRTLNHPVFAYGVGSCAPKAVVKAVGTNVQLKILTSD
FT                   GVTQTICPGDYIAGDNNGIVRIPVQETDISKLVTYIEKSIEVDLLVSEDIKNGIPAKQA
FT                   QNDRRSVLKKYI"
FT   rep_origin      173700..173864
FT                   /note="ARS511; Autonomously Replicating Sequence"
FT   gene            175248..176012
FT                   /gene="TIR1"
FT                   /gene_synonym="SRP1"
FT                   /locus_tag="YER011W"
FT   mRNA            175248..176012
FT                   /gene="TIR1"
FT                   /gene_synonym="SRP1"
FT                   /locus_tag="YER011W"
FT                   /product="GPI-anchored mannoprotein"
FT   CDS_pept        175248..176012
FT                   /codon_start=1
FT                   /gene="TIR1"
FT                   /gene_synonym="SRP1"
FT                   /locus_tag="YER011W"
FT                   /product="GPI-anchored mannoprotein"
FT                   /note="Cell wall mannoprotein; expression is downregulated
FT                   at acidic pH and induced by cold shock and anaerobiosis;
FT                   abundance is increased in cells cultured without shaking;
FT                   member of the Srp1p/Tip1p family of serine-alanine-rich
FT                   proteins"
FT                   /db_xref="GOA:P10863"
FT                   /db_xref="InterPro:IPR000420"
FT                   /db_xref="InterPro:IPR000992"
FT                   /db_xref="UniProtKB/Swiss-Prot:P10863"
FT                   /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
FT                   vacuole [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005199 structural
FT                   constituent of cell wall [PMID:9363789]"
FT                   /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type
FT                   cell wall [PMID:15781460|PMID:8733242]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:26928762]"
FT                   /protein_id="DAA07662.1"
FT                   /translation="MAYTKIALFAAIAALASAQTQDQINELNVILNDVKSHLQEYISLA
FT                   SDSSSGFSLSSMPAGVLDIGMALASATDDSYTTLYSEVDFAGVSKMLTMVPWYSSRLEP
FT                   ALKSLNGDASSSAAPSSSAAPTSSAAPSSSAAPTSSAASSSSEAKSSSAAPSSSEAKSS
FT                   SAAPSSSEAKSSSAAPSSSEAKSSSAAPSSTEAKITSAAPSSTGAKTSAISQITDGQIQ
FT                   ATKAVSEQTENGAAKAFVGMGAGVVAAAAMLL"
FT   repeat_region   176705..176856
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            177099..177170
FT                   /locus_tag="tE(UUC)E1"
FT   tRNA            177099..177170
FT                   /locus_tag="tE(UUC)E1"
FT                   /product="tRNA-Glu"
FT                   /note="tE(UUC)E1; Glutamate tRNA (tRNA-Glu), predicted by
FT                   tRNAscan-SE analysis; thiolation of uridine at wobble
FT                   position (34) requires Ncs6p; target of K. lactis zymocin"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   gene            177835..178431
FT                   /gene="PRE1"
FT                   /locus_tag="YER012W"
FT   mRNA            177835..178431
FT                   /gene="PRE1"
FT                   /locus_tag="YER012W"
FT                   /product="proteasome core particle subunit beta 4"
FT   CDS_pept        177835..178431
FT                   /codon_start=1
FT                   /gene="PRE1"
FT                   /locus_tag="YER012W"
FT                   /product="proteasome core particle subunit beta 4"
FT                   /EC_number="3.4.25.1"
FT                   /note="Beta 4 subunit of the 20S proteasome; localizes to
FT                   the nucleus throughout the cell cycle"
FT                   /db_xref="GOA:P22141"
FT                   /db_xref="InterPro:IPR001353"
FT                   /db_xref="InterPro:IPR016050"
FT                   /db_xref="InterPro:IPR023333"
FT                   /db_xref="InterPro:IPR029055"
FT                   /db_xref="InterPro:IPR035206"
FT                   /db_xref="PDB:1FNT"
FT                   /db_xref="PDB:1G0U"
FT                   /db_xref="PDB:1G65"
FT                   /db_xref="PDB:1JD2"
FT                   /db_xref="PDB:1RYP"
FT                   /db_xref="PDB:1Z7Q"
FT                   /db_xref="PDB:2F16"
FT                   /db_xref="PDB:2FAK"
FT                   /db_xref="PDB:2GPL"
FT                   /db_xref="PDB:2ZCY"
FT                   /db_xref="PDB:3BDM"
FT                   /db_xref="PDB:3D29"
FT                   /db_xref="PDB:3DY3"
FT                   /db_xref="PDB:3DY4"
FT                   /db_xref="PDB:3E47"
FT                   /db_xref="PDB:3GPJ"
FT                   /db_xref="PDB:3GPT"
FT                   /db_xref="PDB:3GPW"
FT                   /db_xref="PDB:3HYE"
FT                   /db_xref="PDB:3JCO"
FT                   /db_xref="PDB:3JCP"
FT                   /db_xref="PDB:3MG0"
FT                   /db_xref="PDB:3MG4"
FT                   /db_xref="PDB:3MG6"
FT                   /db_xref="PDB:3MG7"
FT                   /db_xref="PDB:3MG8"
FT                   /db_xref="PDB:3NZJ"
FT                   /db_xref="PDB:3NZW"
FT                   /db_xref="PDB:3NZX"
FT                   /db_xref="PDB:3OEU"
FT                   /db_xref="PDB:3OEV"
FT                   /db_xref="PDB:3OKJ"
FT                   /db_xref="PDB:3SDI"
FT                   /db_xref="PDB:3SDK"
FT                   /db_xref="PDB:3SHJ"
FT                   /db_xref="PDB:3TDD"
FT                   /db_xref="PDB:3UN4"
FT                   /db_xref="PDB:3UN8"
FT                   /db_xref="PDB:3WXR"
FT                   /db_xref="PDB:4CR2"
FT                   /db_xref="PDB:4CR3"
FT                   /db_xref="PDB:4CR4"
FT                   /db_xref="PDB:4EU2"
FT                   /db_xref="PDB:4FZC"
FT                   /db_xref="PDB:4FZG"
FT                   /db_xref="PDB:4G4S"
FT                   /db_xref="PDB:4GK7"
FT                   /db_xref="PDB:4HNP"
FT                   /db_xref="PDB:4HRC"
FT                   /db_xref="PDB:4HRD"
FT                   /db_xref="PDB:4INR"
FT                   /db_xref="PDB:4INT"
FT                   /db_xref="PDB:4INU"
FT                   /db_xref="PDB:4J70"
FT                   /db_xref="PDB:4JSQ"
FT                   /db_xref="PDB:4JSU"
FT                   /db_xref="PDB:4JT0"
FT                   /db_xref="PDB:4LQI"
FT                   /db_xref="PDB:4LTC"
FT                   /db_xref="PDB:4NNN"
FT                   /db_xref="PDB:4NNW"
FT                   /db_xref="PDB:4NO1"
FT                   /db_xref="PDB:4NO6"
FT                   /db_xref="PDB:4NO8"
FT                   /db_xref="PDB:4NO9"
FT                   /db_xref="PDB:4Q1S"
FT                   /db_xref="PDB:4QBY"
FT                   /db_xref="PDB:4QLQ"
FT                   /db_xref="PDB:4QLS"
FT                   /db_xref="PDB:4QLT"
FT                   /db_xref="PDB:4QLU"
FT                   /db_xref="PDB:4QLV"
FT                   /db_xref="PDB:4QUX"
FT                   /db_xref="PDB:4QUY"
FT                   /db_xref="PDB:4QV0"
FT                   /db_xref="PDB:4QV1"
FT                   /db_xref="PDB:4QV3"
FT                   /db_xref="PDB:4QV4"
FT                   /db_xref="PDB:4QV5"
FT                   /db_xref="PDB:4QV6"
FT                   /db_xref="PDB:4QV7"
FT                   /db_xref="PDB:4QV8"
FT                   /db_xref="PDB:4QV9"
FT                   /db_xref="PDB:4QVL"
FT                   /db_xref="PDB:4QVM"
FT                   /db_xref="PDB:4QVN"
FT                   /db_xref="PDB:4QVP"
FT                   /db_xref="PDB:4QVQ"
FT                   /db_xref="PDB:4QVV"
FT                   /db_xref="PDB:4QVW"
FT                   /db_xref="PDB:4QVY"
FT                   /db_xref="PDB:4QW0"
FT                   /db_xref="PDB:4QW1"
FT                   /db_xref="PDB:4QW3"
FT                   /db_xref="PDB:4QW4"
FT                   /db_xref="PDB:4QW5"
FT                   /db_xref="PDB:4QW6"
FT                   /db_xref="PDB:4QW7"
FT                   /db_xref="PDB:4QWF"
FT                   /db_xref="PDB:4QWG"
FT                   /db_xref="PDB:4QWI"
FT                   /db_xref="PDB:4QWJ"
FT                   /db_xref="PDB:4QWK"
FT                   /db_xref="PDB:4QWL"
FT                   /db_xref="PDB:4QWR"
FT                   /db_xref="PDB:4QWS"
FT                   /db_xref="PDB:4QWU"
FT                   /db_xref="PDB:4QWX"
FT                   /db_xref="PDB:4QXJ"
FT                   /db_xref="PDB:4QZ0"
FT                   /db_xref="PDB:4QZ1"
FT                   /db_xref="PDB:4QZ2"
FT                   /db_xref="PDB:4QZ3"
FT                   /db_xref="PDB:4QZ4"
FT                   /db_xref="PDB:4QZ5"
FT                   /db_xref="PDB:4QZ6"
FT                   /db_xref="PDB:4QZ7"
FT                   /db_xref="PDB:4QZW"
FT                   /db_xref="PDB:4QZX"
FT                   /db_xref="PDB:4QZZ"
FT                   /db_xref="PDB:4R00"
FT                   /db_xref="PDB:4R02"
FT                   /db_xref="PDB:4R17"
FT                   /db_xref="PDB:4R18"
FT                   /db_xref="PDB:4RUR"
FT                   /db_xref="PDB:4V7O"
FT                   /db_xref="PDB:4X6Z"
FT                   /db_xref="PDB:4Y69"
FT                   /db_xref="PDB:4Y6A"
FT                   /db_xref="PDB:4Y6V"
FT                   /db_xref="PDB:4Y6Z"
FT                   /db_xref="PDB:4Y70"
FT                   /db_xref="PDB:4Y74"
FT                   /db_xref="PDB:4Y75"
FT                   /db_xref="PDB:4Y77"
FT                   /db_xref="PDB:4Y78"
FT                   /db_xref="PDB:4Y7W"
FT                   /db_xref="PDB:4Y7X"
FT                   /db_xref="PDB:4Y7Y"
FT                   /db_xref="PDB:4Y80"
FT                   /db_xref="PDB:4Y81"
FT                   /db_xref="PDB:4Y82"
FT                   /db_xref="PDB:4Y84"
FT                   /db_xref="PDB:4Y8G"
FT                   /db_xref="PDB:4Y8H"
FT                   /db_xref="PDB:4Y8I"
FT                   /db_xref="PDB:4Y8J"
FT                   /db_xref="PDB:4Y8K"
FT                   /db_xref="PDB:4Y8L"
FT                   /db_xref="PDB:4Y8M"
FT                   /db_xref="PDB:4Y8N"
FT                   /db_xref="PDB:4Y8O"
FT                   /db_xref="PDB:4Y8P"
FT                   /db_xref="PDB:4Y8Q"
FT                   /db_xref="PDB:4Y8R"
FT                   /db_xref="PDB:4Y8S"
FT                   /db_xref="PDB:4Y8T"
FT                   /db_xref="PDB:4Y8U"
FT                   /db_xref="PDB:4Y9Y"
FT                   /db_xref="PDB:4Y9Z"
FT                   /db_xref="PDB:4YA0"
FT                   /db_xref="PDB:4YA1"
FT                   /db_xref="PDB:4YA2"
FT                   /db_xref="PDB:4YA3"
FT                   /db_xref="PDB:4YA4"
FT                   /db_xref="PDB:4YA5"
FT                   /db_xref="PDB:4YA7"
FT                   /db_xref="PDB:4YA9"
FT                   /db_xref="PDB:4Z1L"
FT                   /db_xref="PDB:5A5B"
FT                   /db_xref="PDB:5AHJ"
FT                   /db_xref="PDB:5BOU"
FT                   /db_xref="PDB:5BXL"
FT                   /db_xref="PDB:5BXN"
FT                   /db_xref="PDB:5CGF"
FT                   /db_xref="PDB:5CGG"
FT                   /db_xref="PDB:5CGH"
FT                   /db_xref="PDB:5CGI"
FT                   /db_xref="PDB:5CZ4"
FT                   /db_xref="PDB:5CZ5"
FT                   /db_xref="PDB:5CZ6"
FT                   /db_xref="PDB:5CZ7"
FT                   /db_xref="PDB:5CZ8"
FT                   /db_xref="PDB:5CZ9"
FT                   /db_xref="PDB:5CZA"
FT                   /db_xref="PDB:5D0S"
FT                   /db_xref="PDB:5D0T"
FT                   /db_xref="PDB:5D0V"
FT                   /db_xref="PDB:5D0W"
FT                   /db_xref="PDB:5D0X"
FT                   /db_xref="PDB:5D0Z"
FT                   /db_xref="PDB:5DKI"
FT                   /db_xref="PDB:5DKJ"
FT                   /db_xref="PDB:5FG7"
FT                   /db_xref="PDB:5FG9"
FT                   /db_xref="PDB:5FGA"
FT                   /db_xref="PDB:5FGD"
FT                   /db_xref="PDB:5FGE"
FT                   /db_xref="PDB:5FGF"
FT                   /db_xref="PDB:5FGG"
FT                   /db_xref="PDB:5FGH"
FT                   /db_xref="PDB:5FGI"
FT                   /db_xref="PDB:5FHS"
FT                   /db_xref="PDB:5JHR"
FT                   /db_xref="PDB:5JHS"
FT                   /db_xref="PDB:5L52"
FT                   /db_xref="PDB:5L54"
FT                   /db_xref="PDB:5L55"
FT                   /db_xref="PDB:5L5A"
FT                   /db_xref="PDB:5L5B"
FT                   /db_xref="PDB:5L5D"
FT                   /db_xref="PDB:5L5E"
FT                   /db_xref="PDB:5L5F"
FT                   /db_xref="PDB:5L5H"
FT                   /db_xref="PDB:5L5I"
FT                   /db_xref="PDB:5L5J"
FT                   /db_xref="PDB:5L5O"
FT                   /db_xref="PDB:5L5P"
FT                   /db_xref="PDB:5L5Q"
FT                   /db_xref="PDB:5L5R"
FT                   /db_xref="PDB:5L5S"
FT                   /db_xref="PDB:5L5T"
FT                   /db_xref="PDB:5L5U"
FT                   /db_xref="PDB:5L5V"
FT                   /db_xref="PDB:5L5W"
FT                   /db_xref="PDB:5L5X"
FT                   /db_xref="PDB:5L5Y"
FT                   /db_xref="PDB:5L5Z"
FT                   /db_xref="PDB:5L60"
FT                   /db_xref="PDB:5L61"
FT                   /db_xref="PDB:5L62"
FT                   /db_xref="PDB:5L63"
FT                   /db_xref="PDB:5L64"
FT                   /db_xref="PDB:5L65"
FT                   /db_xref="PDB:5L66"
FT                   /db_xref="PDB:5L67"
FT                   /db_xref="PDB:5L68"
FT                   /db_xref="PDB:5L69"
FT                   /db_xref="PDB:5L6A"
FT                   /db_xref="PDB:5L6B"
FT                   /db_xref="PDB:5L6C"
FT                   /db_xref="PDB:5LAI"
FT                   /db_xref="PDB:5LAJ"
FT                   /db_xref="PDB:5LTT"
FT                   /db_xref="PDB:5M2B"
FT                   /db_xref="PDB:5MP9"
FT                   /db_xref="PDB:5MPA"
FT                   /db_xref="PDB:5MPB"
FT                   /db_xref="PDB:5MPC"
FT                   /db_xref="PDB:5NIF"
FT                   /db_xref="PDB:5WVI"
FT                   /db_xref="PDB:5WVK"
FT                   /db_xref="PDB:6EF3"
FT                   /db_xref="PDB:6FVT"
FT                   /db_xref="PDB:6FVU"
FT                   /db_xref="PDB:6FVV"
FT                   /db_xref="PDB:6FVW"
FT                   /db_xref="PDB:6FVX"
FT                   /db_xref="PDB:6FVY"
FT                   /db_xref="PDB:6G7F"
FT                   /db_xref="PDB:6G8M"
FT                   /db_xref="PDB:6G8N"
FT                   /db_xref="PDB:6GOP"
FT                   /db_xref="PDB:6H39"
FT                   /db_xref="PDB:6HTB"
FT                   /db_xref="PDB:6HTC"
FT                   /db_xref="PDB:6HTD"
FT                   /db_xref="PDB:6HTP"
FT                   /db_xref="PDB:6HTR"
FT                   /db_xref="PDB:6HUB"
FT                   /db_xref="PDB:6HUC"
FT                   /db_xref="PDB:6HUQ"
FT                   /db_xref="PDB:6HUU"
FT                   /db_xref="PDB:6HUV"
FT                   /db_xref="PDB:6HV3"
FT                   /db_xref="PDB:6HV4"
FT                   /db_xref="PDB:6HV5"
FT                   /db_xref="PDB:6HV7"
FT                   /db_xref="PDB:6HVA"
FT                   /db_xref="PDB:6HVR"
FT                   /db_xref="PDB:6HVS"
FT                   /db_xref="PDB:6HVT"
FT                   /db_xref="PDB:6HVU"
FT                   /db_xref="PDB:6HVV"
FT                   /db_xref="PDB:6HVW"
FT                   /db_xref="PDB:6HVX"
FT                   /db_xref="PDB:6HVY"
FT                   /db_xref="PDB:6HW0"
FT                   /db_xref="PDB:6HW3"
FT                   /db_xref="PDB:6HW4"
FT                   /db_xref="PDB:6HW5"
FT                   /db_xref="PDB:6HW6"
FT                   /db_xref="PDB:6HW7"
FT                   /db_xref="PDB:6HW8"
FT                   /db_xref="PDB:6HW9"
FT                   /db_xref="PDB:6HWA"
FT                   /db_xref="PDB:6HWB"
FT                   /db_xref="PDB:6HWC"
FT                   /db_xref="PDB:6HWD"
FT                   /db_xref="PDB:6HWE"
FT                   /db_xref="PDB:6HWF"
FT                   /db_xref="PDB:6J2C"
FT                   /db_xref="PDB:6J2N"
FT                   /db_xref="PDB:6J2Q"
FT                   /db_xref="PDB:6J2X"
FT                   /db_xref="PDB:6J30"
FT                   /db_xref="UniProtKB/Swiss-Prot:P22141"
FT                   /experiment="EXISTENCE:curator inference:GO:0034515
FT                   proteasome storage granule [PMID:9087403]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:10419517]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
FT                   reticulum membrane [PMID:15973433]"
FT                   /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal
FT                   ubiquitin-independent protein catabolic process
FT                   [PMID:19162040]"
FT                   /experiment="EXISTENCE:direct assay:GO:0019774 proteasome
FT                   core complex, beta-subunit complex [PMID:9087403]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043161
FT                   proteasome-mediated ubiquitin-dependent protein catabolic
FT                   process [PMID:11545745|PMID:19029916]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0061133
FT                   endopeptidase activator activity [PMID:8808631]"
FT                   /protein_id="DAA07663.1"
FT                   /translation="MDIILGIRVQDSVILASSKAVTRGISVLKDSDDKTRQLSPHTLMS
FT                   FAGEAGDTVQFAEYIQANIQLYSIREDYELSPQAVSSFVRQELAKSIRSRRPYQVNVLI
FT                   GGYDKKKNKPELYQIDYLGTKVELPYGAHGYSGFYTFSLLDHHYRPDMTTEEGLDLLKL
FT                   CVQELEKRMPMDFKGVIVKIVDKDGIRQVDDFQAQ"
FT   gene            178841..182278
FT                   /gene="PRP22"
FT                   /locus_tag="YER013W"
FT   mRNA            178841..182278
FT                   /gene="PRP22"
FT                   /locus_tag="YER013W"
FT                   /product="DEAH-box ATP-dependent RNA helicase PRP22"
FT   CDS_pept        178841..182278
FT                   /codon_start=1
FT                   /gene="PRP22"
FT                   /locus_tag="YER013W"
FT                   /product="DEAH-box ATP-dependent RNA helicase PRP22"
FT                   /EC_number="3.6.4.13"
FT                   /note="DEAH-box RNA-dependent ATPase/ATP-dependent RNA
FT                   helicase; associates with lariat intermediates before the
FT                   second catalytic step of splicing; mediates ATP-dependent
FT                   mRNA release from the spliceosome and unwinds RNA duplexes;
FT                   required for proofreading the exon ligation reaction"
FT                   /db_xref="GOA:P24384"
FT                   /db_xref="InterPro:IPR001650"
FT                   /db_xref="InterPro:IPR002464"
FT                   /db_xref="InterPro:IPR003029"
FT                   /db_xref="InterPro:IPR007502"
FT                   /db_xref="InterPro:IPR011709"
FT                   /db_xref="InterPro:IPR012340"
FT                   /db_xref="InterPro:IPR014001"
FT                   /db_xref="InterPro:IPR022967"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="PDB:5MQ0"
FT                   /db_xref="PDB:5YLZ"
FT                   /db_xref="PDB:6BK8"
FT                   /db_xref="PDB:6EXN"
FT                   /db_xref="UniProtKB/Swiss-Prot:P24384"
FT                   /experiment="EXISTENCE:direct assay:GO:0000350 generation
FT                   of catalytic spliceosome for second transesterification
FT                   step [PMID:12212850]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000386 second
FT                   spliceosomal transesterification activity [PMID:12212850]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase
FT                   activity [PMID:9582286]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000350
FT                   generation of catalytic spliceosome for second
FT                   transesterification step [PMID:22408182]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000386 second
FT                   spliceosomal transesterification activity [PMID:9524130]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000390
FT                   spliceosomal complex disassembly [PMID:9524130]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0071007 U2-type
FT                   catalytic step 2 spliceosome [PMID:9524130]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0071021 U2-type
FT                   post-spliceosomal complex [PMID:12212850]"
FT                   /protein_id="DAA07664.1"
FT                   /translation="MSDISKLIGAIVGSDDPVIIEFVLNIINKSGNLQEFIRNIQKLDA
FT                   GISYEDSIKMYNAFLGKQEEEKVRNKVKSSPLSQKINQVLKDDVNLDDPVVTEFVLSIL
FT                   NKSKSITEFQEQLNLMQSGLDNETIFKIYQIASPPVMKEEVSVLPSTKIPAKIEAKIEE
FT                   EVQKIESLDPSPVLHKVYEGKVRNITTFGCFVQIFGTRMKNCDGLVHISEMSDQRTLDP
FT                   HDVVRQGQHIFVEVIKIQNNGKISLSMKNIDQHSGEIRKRNTESVEDRGRSNDAHTSRN
FT                   MKNKIKRRALTSPERWEIRQLIASGAASIDDYPELKDEIPINTSYLTAKRDDGSIVNGN
FT                   TEKVDSKLEEQQRDETDEIDVELNTDDGPKFLKDQQVKGAKKYEMPKITKVPRGFMNRS
FT                   AINGSNAIRDHREEKLRKKREIEQQIRKQQSFDDPTKNKKDSRNEIQMLKNQLIVTEWE
FT                   KNRMNESISYGKRTSLPISAQRQTLPVYAMRSELIQAVRDNQFLVIVGETGSGKTTQIT
FT                   QYLDEEGFSNYGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHDVGYTIRFEDVTGPDTRI
FT                   KYMTDGMLQREALLDPEMSKYSVIMLDEAHERTVATDVLFALLKKAAIKRPELKVIVTS
FT                   ATLNSAKFSEYFLNCPIINIPGKTFPVEVLYSQTPQMDYIEAALDCVIDIHINEGPGDI
FT                   LVFLTGQEEIDSCCEILYDRVKTLGDSIGELLILPVYSALPSEIQSKIFEPTPKGSRKV
FT                   VFATNIAETSITIDGIYYVVDPGFAKINIYNARAGIEQLIVSPISQAQANQRKGRAGRT
FT                   GPGKCYRLYTESAFYNEMLENTVPEIQRQNLSHTILMLKAMGINDLLKFDFMDPPPKNL
FT                   MLNALTELYHLQSLDDEGKLTNLGKEMSLFPMDPTLSRSLLSSVDNQCSDEIVTIISML
FT                   SVQNVFYRPKDRQLEADSKKAKFHHPYGDHLTLLNVYTRWQQANYSEQYCKTNFLHFRH
FT                   LKRARDVKSQISMIFKKIGLKLISCHSDPDLIRKTFVSGFFMNAAKRDSQVGYKTINGG
FT                   TEVGIHPSSSLYGKEYEYVMYHSIVLTSREYMSQVTSIEPQWLLEVAPHFYKAGDAESQ
FT                   SRKKAKIIPLHNKFAKDQNSWRLSSIRQSRERALGIKR"
FT   gene            182600..184219
FT                   /gene="HEM14"
FT                   /locus_tag="YER014W"
FT   mRNA            182600..184219
FT                   /gene="HEM14"
FT                   /locus_tag="YER014W"
FT                   /product="oxygen-dependent protoporphyrinogen oxidase"
FT   CDS_pept        182600..184219
FT                   /codon_start=1
FT                   /gene="HEM14"
FT                   /locus_tag="YER014W"
FT                   /product="oxygen-dependent protoporphyrinogen oxidase"
FT                   /EC_number="1.3.3.4"
FT                   /note="Protoporphyrinogen oxidase; a mitochondrial enzyme
FT                   that catalyzes the seventh step in the heme biosynthetic
FT                   pathway, converting protoporphyrinogen IX to protoporphyrin
FT                   IX; inhibited by diphenyl ether-type herbicides"
FT                   /db_xref="GOA:P40012"
FT                   /db_xref="InterPro:IPR004572"
FT                   /db_xref="InterPro:IPR036188"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40012"
FT                   /experiment="EXISTENCE:direct assay:GO:0004729
FT                   oxygen-dependent protoporphyrinogen oxidase activity
FT                   [PMID:7798202]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion
FT                   [PMID:14576278|PMID:16823961|PMID:24769239|PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005743
FT                   mitochondrial inner membrane [PMID:7798202]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004729
FT                   oxygen-dependent protoporphyrinogen oxidase activity
FT                   [PMID:7052077]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006783 heme
FT                   biosynthetic process [PMID:7035824]"
FT                   /protein_id="DAA07665.1"
FT                   /translation="MLLPLTKLKPRAKVAVVGGGVSGLCFTYFLSKLRPDVEITLFESQ
FT                   NRTGGWIYSCNTRDMSGNPIMLEKGPRTLRGVSDGTVLIMDTLKDLGKEAVIQSIDKGC
FT                   IADKKFLLDPSDKLVQVPNSISTTVKFLLNPLGKGLITGMMGEWFRKKSPHPGQDESVE
FT                   SICDRRFGNNYISNNMISALLRGIYGDDVSLLSAKRTFKKIYYNELKHGSNTQAMIDNM
FT                   RGKSRSKKTENLHQSLTGCLNDYSNAFGKDRSKLLDLSNTLKKYPMLGLAGGLETFPKI
FT                   VRNALNEFKNVKIVTGNPVTQIMKRPANETTIGLKAKSGDQYETFDHLRLTITPPKIAK
FT                   LLPKDQNSLSKLLDEIQSNTIILVNYYLPNKDVIDADLQGFGYLVPKSNKNPGKLLGVI
FT                   FDSVIERNFKPLFDKLSTNPNALNKYTKVTAMIGGCMLNEHGVPVVPSREVTINAVKDA
FT                   LNNHLGISNKDLEAGQWEFTIADRCLPRFHVGYDAWQERAERKLQESYGQTVSVGGMGF
FT                   SRSPGVPDVIVDGFNDALQLSK"
FT   gene            complement(183731..184700)
FT                   /gene="BUD25"
FT                   /locus_tag="YER014C-A"
FT   mRNA            complement(join(183731..184169,184678..184700))
FT                   /gene="BUD25"
FT                   /locus_tag="YER014C-A"
FT                   /product="Bud25p"
FT   CDS_pept        complement(join(183731..184169,184678..184700))
FT                   /codon_start=1
FT                   /gene="BUD25"
FT                   /locus_tag="YER014C-A"
FT                   /product="Bud25p"
FT                   /note="Protein involved in bud-site selection; diploid
FT                   mutants display a random budding pattern instead of the
FT                   wild-type bipolar pattern"
FT                   /db_xref="EnsemblGenomes-Gn:YER014C-A"
FT                   /db_xref="EnsemblGenomes-Tr:YER014C-A"
FT                   /db_xref="GOA:P85052"
FT                   /db_xref="UniProtKB/Swiss-Prot:P85052"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular
FT                   bud site selection [PMID:11452010]"
FT                   /protein_id="DAA07666.1"
FT                   /translation="MFCTWDSWDTGTSRKSHSPHRNCLAVRFLQLPFSSFLPCVITYMK
FT                   SWQTSIGDSEFPLTSFQILVTDAEVVVQRIFDCINGYLPGWHYRNTVFIEHTTSYHRSH
FT                   FCIFVEGVWVCGEFVKKWFEIPFDNRIENYTKQFPWILIGFGNQVSKAL"
FT   gene            184541..186775
FT                   /gene="FAA2"
FT                   /gene_synonym="FAM1"
FT                   /locus_tag="YER015W"
FT   mRNA            184541..186775
FT                   /gene="FAA2"
FT                   /gene_synonym="FAM1"
FT                   /locus_tag="YER015W"
FT                   /product="medium-chain fatty acid-CoA ligase FAA2"
FT   CDS_pept        184541..186775
FT                   /codon_start=1
FT                   /gene="FAA2"
FT                   /gene_synonym="FAM1"
FT                   /locus_tag="YER015W"
FT                   /product="medium-chain fatty acid-CoA ligase FAA2"
FT                   /EC_number="6.2.1.3"
FT                   /note="Medium chain fatty acyl-CoA synthetase; activates
FT                   imported fatty acids; accepts a wide range of fatty acid
FT                   chain lengths with a preference for medium chains,
FT                   C9:0-C13:0; localized to the peroxisome; comparative
FT                   analysis suggests that a mitochondrially targeted form may
FT                   result from translation starting at a non-canonical codon
FT                   upstream of the annotated start codon"
FT                   /db_xref="GOA:P39518"
FT                   /db_xref="InterPro:IPR000873"
FT                   /db_xref="InterPro:IPR020845"
FT                   /db_xref="InterPro:IPR042099"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39518"
FT                   /experiment="EXISTENCE:direct assay:GO:0004467 long-chain
FT                   fatty acid-CoA ligase activity [PMID:8206942]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome
FT                   [PMID:8670886]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031956 medium-chain
FT                   fatty acid-CoA ligase activity [PMID:8206942]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0001676
FT                   long-chain fatty acid metabolic process [PMID:7962057]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0031957 very
FT                   long-chain fatty acid-CoA ligase activity [PMID:9988704]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001676
FT                   long-chain fatty acid metabolic process [PMID:7962057]"
FT                   /protein_id="DAA07667.1"
FT                   /translation="MAAPDYALTDLIESDPRFESLKTRLAGYTKGSDEYIEELYSQLPL
FT                   TSYPRYKTFLKKQAVAISNPDNEAGFSSIYRSSLSSENLVSCVDKNLRTAYDHFMFSAR
FT                   RWPQRDCLGSRPIDKATGTWEETFRFESYSTVSKRCHNIGSGILSLVNTKRKRPLEAND
FT                   FVVAILSHNNPEWILTDLACQAYSLTNTALYETLGPNTSEYILNLTEAPILIFAKSNMY
FT                   HVLKMVPDMKFVNTLVCMDELTHDELRMLNESLLPVKCNSLNEKITFFSLEQVEQVGCF
FT                   NKIPAIPPTPDSLYTISFTSGTTGLPKGVEMSHRNIASGIAFAFSTFRIPPDKRNQQLY
FT                   DMCFLPLAHIFERMVIAYDLAIGFGIGFLHKPDPTVLVEDLKILKPYAVALVPRILTRF
FT                   EAGIKNALDKSTVQRNVANTILDSKSARFTARGGPDKSIMNFLVYHRVLIDKIRDSLGL
FT                   SNNSFIITGSAPISKDTLLFLRSALDIGIRQGYGLTETFAGVCLSEPFEKDVGSCGAIG
FT                   ISAECRLKSVPEMGYHADKDLKGELQIRGPQVFERYFKNPNETSKAVDQDGWFSTGDVA
FT                   FIDGKGRISVIDRVKNFFKLAHGEYIAPEKIENIYLSSCPYITQIFVFGDPLKTFLVGI
FT                   VGVDVDAAQPILAAKHPEVKTWTKEVLVENLNRNKKLRKEFLNKINKCTDGLQGFEKLH
FT                   NIKVGLEPLTLEDDVVTPTFKIKRAKASKFFKDTLDQLYAEGSLVKTEKL"
FT   gene            188277..189311
FT                   /gene="BIM1"
FT                   /gene_synonym="YEB1"
FT                   /locus_tag="YER016W"
FT   mRNA            188277..189311
FT                   /gene="BIM1"
FT                   /gene_synonym="YEB1"
FT                   /locus_tag="YER016W"
FT                   /product="microtubule-binding protein BIM1"
FT   CDS_pept        188277..189311
FT                   /codon_start=1
FT                   /gene="BIM1"
FT                   /gene_synonym="YEB1"
FT                   /locus_tag="YER016W"
FT                   /product="microtubule-binding protein BIM1"
FT                   /note="Microtubule plus end-tracking protein; together with
FT                   Kar9p makes up the cortical microtubule capture site and
FT                   delays the exit from mitosis when the spindle is oriented
FT                   abnormally; homolog of human end binding protein 1 (EB1)"
FT                   /db_xref="GOA:P40013"
FT                   /db_xref="InterPro:IPR001715"
FT                   /db_xref="InterPro:IPR004953"
FT                   /db_xref="InterPro:IPR027328"
FT                   /db_xref="InterPro:IPR036133"
FT                   /db_xref="InterPro:IPR036872"
FT                   /db_xref="PDB:2QJX"
FT                   /db_xref="PDB:4E61"
FT                   /db_xref="PDB:6FC6"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40013"
FT                   /experiment="EXISTENCE:direct assay:GO:0000922 spindle pole
FT                   [PMID:10352017]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005819 spindle
FT                   [PMID:10352017]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic
FT                   microtubule [PMID:10352017]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031116 positive
FT                   regulation of microtubule polymerization [PMID:20392838]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035371 microtubule
FT                   plus-end [PMID:20392838]"
FT                   /experiment="EXISTENCE:direct assay:GO:0051010 microtubule
FT                   plus-end binding [PMID:20392838]"
FT                   /experiment="EXISTENCE:direct assay:GO:0051233 spindle
FT                   midzone [PMID:10352017]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007064
FT                   mitotic sister chromatid cohesion [PMID:14742714]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0030543
FT                   2-micrometer plasmid partitioning [PMID:28004422]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0031578
FT                   mitotic spindle orientation checkpoint [PMID:11285282]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007019
FT                   microtubule depolymerization [PMID:10352017]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007026 negative
FT                   regulation of microtubule depolymerization [PMID:10352017]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic
FT                   sister chromatid cohesion [PMID:14742714]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear
FT                   migration along microtubule [PMID:10352017]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030543
FT                   2-micrometer plasmid partitioning [PMID:28004422]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1904825 protein
FT                   localization to microtubule plus-end [PMID:29576319]"
FT                   /protein_id="DAA07668.1"
FT                   /translation="MSAGIGESRTELLTWLNGLLNLNYKKIEECGTGAAYCQIMDSIYG
FT                   DLPMNRVKFNATAEYEFQTNYKILQSCFSRHGIEKTVYVDKLIRCKFQDNLEFLQWLKK
FT                   HWIRHKDESVYDPDARRKYRPIITNNSATKPRTVSNPTTAKRSSSTGTGSAMSGGLATR
FT                   HSSLGINGSRKTSVTQGQLVAIQAELTKSQETIGSLNEEIEQYKGTVSTLEIEREFYFN
FT                   KLRDIEILVHTTQDLINEGVYKFNDETITGHGNGNGGALLRFVKKVESILYATAEGFEM
FT                   NDGEDELNDKNLGEHGTVPNQGGYANSNGEVNGNEGSNHDVIMQNDEGEVGVSNNLIID
FT                   EETF"
FT   gene            complement(189503..191788)
FT                   /gene="AFG3"
FT                   /gene_synonym="YTA10"
FT                   /locus_tag="YER017C"
FT   mRNA            complement(189503..191788)
FT                   /gene="AFG3"
FT                   /gene_synonym="YTA10"
FT                   /locus_tag="YER017C"
FT                   /product="AAA family ATPase AFG3"
FT   CDS_pept        complement(189503..191788)
FT                   /codon_start=1
FT                   /gene="AFG3"
FT                   /gene_synonym="YTA10"
FT                   /locus_tag="YER017C"
FT                   /product="AAA family ATPase AFG3"
FT                   /note="Mitochondrial inner membrane m-AAA protease
FT                   component; mediates degradation of misfolded or unassembled
FT                   proteins; also required for correct assembly of
FT                   mitochondrial enzyme complexes; involved in cytoplasmic
FT                   mRNA translation and aging; expression of human homolog
FT                   AFG3L2 can complement yeast yta12 afg3 double mutant"
FT                   /db_xref="GOA:P39925"
FT                   /db_xref="InterPro:IPR000642"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="InterPro:IPR003959"
FT                   /db_xref="InterPro:IPR003960"
FT                   /db_xref="InterPro:IPR005936"
FT                   /db_xref="InterPro:IPR011546"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR037219"
FT                   /db_xref="InterPro:IPR041569"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39925"
FT                   /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
FT                   vacuole membrane [PMID:23509072]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005743
FT                   mitochondrial inner membrane [PMID:7926051]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005745 m-AAA
FT                   complex [PMID:8681382]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016887 ATPase
FT                   activity [PMID:19748354]"
FT                   /experiment="EXISTENCE:direct assay:GO:0097002
FT                   mitochondrial inner boundary membrane [PMID:19019989]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001302
FT                   replicative cell aging [PMID:23167605]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006465 signal
FT                   peptide processing [PMID:12417197]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006508
FT                   proteolysis [PMID:8681382]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008237
FT                   metallopeptidase activity [PMID:8681382]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATPase
FT                   activity [PMID:19748354]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein
FT                   import into mitochondrial matrix [PMID:27398316]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034622 cellular
FT                   protein-containing complex assembly [PMID:8681382]"
FT                   /protein_id="DAA07669.1"
FT                   /translation="MMMWQRYARGAPRSLTSLSFGKASRISTVKPVLRSRMPVHQRLQT
FT                   LSGLATRNTIHRSTQIRSFHISWTRLNENRPNKEGEGKNNGNKDNNSNKEDGKDKRNEF
FT                   GSLSEYFRSKEFANTMFLTIGFTIIFTLLTPSSNNSGDDSNRVLTFQDFKTKYLEKGLV
FT                   SKIYVVNKFLVEAELVNTKQVVSFTIGSVDIFEEQMDQIQDLLNIPPRDRIPIKYIERS
FT                   SPFTFLFPFLPTIILLGGLYFITRKINSSPPNANGGGGGGLGGMFNVGKSRAKLFNKET
FT                   DIKISFKNVAGCDEAKQEIMEFVHFLKNPGKYTKLGAKIPRGAILSGPPGTGKTLLAKA
FT                   TAGEANVPFLSVSGSEFVEMFVGVGASRVRDLFTQARSMAPSIIFIDEIDAIGKERGKG
FT                   GALGGANDEREATLNQLLVEMDGFTTSDQVVVLAGTNRPDVLDNALMRPGRFDRHIQID
FT                   SPDVNGRQQIYLVHLKRLNLDPLLTDDMNNLSGKLATLTPGFTGADIANACNEAALIAA
FT                   RHNDPYITIHHFEQAIERVIAGLEKKTRVLSKEEKRSVAYHEAGHAVCGWFLKYADPLL
FT                   KVSIIPRGQGALGYAQYLPPDQYLISEEQFRHRMIMALGGRVSEELHFPSVTSGAHDDF
FT                   KKVTQMANAMVTSLGMSPKIGYLSFDQNDGNFKVNKPFSNKTARTIDLEVKSIVDDAHR
FT                   ACTELLTKNLDKVDLVAKELLRKEAITREDMIRLLGPRPFKERNEAFEKYLDPKSNTEP
FT                   PEAPAATN"
FT   gene            complement(191959..192624)
FT                   /gene="SPC25"
FT                   /locus_tag="YER018C"
FT   mRNA            complement(191959..192624)
FT                   /gene="SPC25"
FT                   /locus_tag="YER018C"
FT                   /product="kinetochore-associated Ndc80 complex subunit
FT                   SPC25"
FT   CDS_pept        complement(191959..192624)
FT                   /codon_start=1
FT                   /gene="SPC25"
FT                   /locus_tag="YER018C"
FT                   /product="kinetochore-associated Ndc80 complex subunit
FT                   SPC25"
FT                   /note="Component of the kinetochore-associated Ndc80
FT                   complex; involved in chromosome segregation, spindle
FT                   checkpoint activity, and kinetochore clustering;
FT                   evolutionarily conserved; other members include Ndc80p,
FT                   Nuf2p, Spc24p, and Spc25p"
FT                   /db_xref="GOA:P40014"
FT                   /db_xref="PDB:2FTX"
FT                   /db_xref="PDB:2FV4"
FT                   /db_xref="PDB:4GEQ"
FT                   /db_xref="PDB:5T6J"
FT                   /db_xref="PDB:5TCS"
FT                   /db_xref="PDB:5TD8"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40014"
FT                   /experiment="EXISTENCE:direct assay:GO:0000778 condensed
FT                   nuclear chromosome kinetochore [PMID:11511347]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031262 Ndc80
FT                   complex [PMID:11179222|PMID:11266451]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000778
FT                   condensed nuclear chromosome kinetochore [PMID:11179222]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007059
FT                   chromosome segregation [PMID:11266451]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0098653
FT                   centromere clustering [PMID:11179222]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031262
FT                   Ndc80 complex [PMID:11179222]"
FT                   /protein_id="DAA07670.1"
FT                   /translation="MASIDAFSDLERRMDGFQKDVAQVLARQQNHARQQLQQFQAEMRQ
FT                   LHNQHQHLIDELQRLATQRTALQQQIHAAQQATNTTREQWRSYHERESELSRRQSTLAA
FT                   QSRELDSLLQQRGKECVQLRARWAAQSGNDAAEVALYERLLQLRVLPGASDVHDVRFVF
FT                   GDDSRCWIEVAMHGDHVIGNSHPALDPKSRATLEHVLTVQGDLAAFLVVARDMLLASL"
FT   gene            192797..194230
FT                   /gene="ISC1"
FT                   /locus_tag="YER019W"
FT   mRNA            192797..194230
FT                   /gene="ISC1"
FT                   /locus_tag="YER019W"
FT                   /product="inositol phosphosphingolipid phospholipase"
FT   CDS_pept        192797..194230
FT                   /codon_start=1
FT                   /gene="ISC1"
FT                   /locus_tag="YER019W"
FT                   /product="inositol phosphosphingolipid phospholipase"
FT                   /note="Inositol phosphosphingolipid phospholipase C;
FT                   mitochondrial membrane localized; hydrolyzes complex
FT                   sphingolipids to produce ceramide; activates genes required
FT                   for non-fermentable carbon source metabolism during diauxic
FT                   shift; activated by phosphatidylserine, cardiolipin, and
FT                   phosphatidylglycerol; mediates Na+ and Li+ halotolerance;
FT                   ortholog of mammalian neutral sphingomyelinase type 2"
FT                   /db_xref="GOA:P40015"
FT                   /db_xref="InterPro:IPR005135"
FT                   /db_xref="InterPro:IPR036691"
FT                   /db_xref="InterPro:IPR038772"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40015"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14699160]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:14699160|PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030149 sphingolipid
FT                   catabolic process [PMID:11006294]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031307 integral
FT                   component of mitochondrial outer membrane [PMID:17880915]"
FT                   /experiment="EXISTENCE:direct assay:GO:0052712 inositol
FT                   phosphosphingolipid phospholipase activity [PMID:11006294]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:26928762]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009651 response
FT                   to salt stress [PMID:12180980]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0046513 ceramide
FT                   biosynthetic process [PMID:17880915|PMID:23620586]"
FT                   /protein_id="DAA07671.1"
FT                   /translation="MYNRKDRDVHERKEDGQSEFEALNGTNAIMSDNSKAYSIKFLTFN
FT                   TWGLKYVSKHRKERLRAIADKLAGHSMLTPISDELLPNGGDSNENEDYDVIALQEIWCV
FT                   EDWKYLASACASKYPYQRLFHSGILTGPGLAILSKVPIESTFLYRFPINGRPSAVFRGD
FT                   WYVGKSIAITVLNTGTRPIAIMNSHMHAPYAKQGDAAYLCHRSCQAWDFSRLIKLYRQA
FT                   GYAVIVVGDLNSRPGSLPHKFLTQEAGLVDSWEQLHGKQDLAVIARLSPLQQLLKGCTT
FT                   CDSLLNTWRAQRQPDEACRLDYALIDPDFLQTVDAGVRFTERIPHLDCSVSDHFAYSCT
FT                   LNIVPQGTESRPSTSVKRAKTHDRELILQRYSNYETMIECIHTYLKTAQRQKFFRGLHF
FT                   WASILLLIASLVVTTFTANKAGWSSIFWVLFAIAVSISGTIDGAISFLFGRSEIRALIE
FT                   VEQEVLDAEHHLQTFLSEK"
FT   gene            complement(194273..194539)
FT                   /gene="SBH2"
FT                   /gene_synonym="SEB2"
FT                   /locus_tag="YER019C-A"
FT   mRNA            complement(194273..194539)
FT                   /gene="SBH2"
FT                   /gene_synonym="SEB2"
FT                   /locus_tag="YER019C-A"
FT                   /product="Arf family guanine nucleotide exchange factor
FT                   SBH2"
FT   CDS_pept        complement(194273..194539)
FT                   /codon_start=1
FT                   /gene="SBH2"
FT                   /gene_synonym="SEB2"
FT                   /locus_tag="YER019C-A"
FT                   /product="Arf family guanine nucleotide exchange factor
FT                   SBH2"
FT                   /note="Ssh1p-Sss1p-Sbh2p complex component; involved in
FT                   protein translocation into the endoplasmic reticulum; SBH2
FT                   has a paralog, SBH1, that arose from the whole genome
FT                   duplication"
FT                   /db_xref="GOA:P52871"
FT                   /db_xref="InterPro:IPR016482"
FT                   /db_xref="InterPro:IPR030671"
FT                   /db_xref="PDB:2WW9"
FT                   /db_xref="PDB:2WWA"
FT                   /db_xref="UniProtKB/Swiss-Prot:P52871"
FT                   /experiment="EXISTENCE:direct assay:GO:0005086 ARF
FT                   guanyl-nucleotide exchange factor activity [PMID:12750387]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071261 Ssh1
FT                   translocon complex [PMID:8612571]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006614
FT                   SRP-dependent cotranslational protein targeting to membrane
FT                   [PMID:18347066]"
FT                   /protein_id="DAA07672.1"
FT                   /translation="MAASVPPGGQRILQKRRQAQSIKEKQAKQTPTSTRQAGYGGSSSS
FT                   ILKLYTDEANGFRVDSLVVLFLSVGFIFSVIALHLLTKFTHII"
FT   gene            195168..196517
FT                   /gene="GPA2"
FT                   /gene_synonym="SSP101"
FT                   /locus_tag="YER020W"
FT   mRNA            195168..196517
FT                   /gene="GPA2"
FT                   /gene_synonym="SSP101"
FT                   /locus_tag="YER020W"
FT                   /product="guanine nucleotide-binding protein subunit alpha"
FT   CDS_pept        195168..196517
FT                   /codon_start=1
FT                   /gene="GPA2"
FT                   /gene_synonym="SSP101"
FT                   /locus_tag="YER020W"
FT                   /product="guanine nucleotide-binding protein subunit alpha"
FT                   /note="Nucleotide binding alpha subunit of the
FT                   heterotrimeric G protein; interacts with the receptor
FT                   Gpr1p, has signaling role in response to nutrients;
FT                   required for the recruitment of Ras-GTP at the plasma
FT                   membrane and in the nucleus"
FT                   /db_xref="GOA:P10823"
FT                   /db_xref="InterPro:IPR001019"
FT                   /db_xref="InterPro:IPR002975"
FT                   /db_xref="InterPro:IPR011025"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="UniProtKB/Swiss-Prot:P10823"
FT                   /experiment="EXISTENCE:direct assay:GO:0003924 GTPase
FT                   activity [PMID:16924114]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:16030250|PMID:16622836]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0010255
FT                   glucose mediated signaling pathway
FT                   [PMID:10361302|PMID:2830616]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001302
FT                   replicative cell aging [PMID:15722108]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive
FT                   growth in response to glucose limitation [PMID:12150916]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase
FT                   activity [PMID:9384580]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007124
FT                   pseudohyphal growth
FT                   [PMID:10454558|PMID:10655215|PMID:9384580]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal
FT                   transduction [PMID:10454558]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007189
FT                   adenylate cyclase-activating G protein-coupled receptor
FT                   signaling pathway [PMID:9628870]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008361
FT                   regulation of cell size [PMID:12089449]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009757 hexose
FT                   mediated signaling [PMID:10655215]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010255 glucose
FT                   mediated signaling pathway [PMID:2830616|PMID:9628870]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030437
FT                   ascospore formation [PMID:10454558]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0007189
FT                   adenylate cyclase-activating G protein-coupled receptor
FT                   signaling pathway [PMID:16924114]"
FT                   /protein_id="DAA07673.1"
FT                   /translation="MGLCASSEKNGSTPDTQTASAGSDNVGKAKVPPKQEPQKTVRTVN
FT                   TANQQEKQQQRQQQPSPHNVKDRKEQNGSINNAISPTATANTSGSQQINIDSALRDRSS
FT                   NVAAQPSLSDASSGSNDKELKVLLLGAGESGKSTVLQQLKILHQNGFSEQEIKEYIPLI
FT                   YQNLLEIGRNLIQARTRFNVNLEPECELTQQDLSRTMSYEMPNNYTGQFPEDIAGVIST
FT                   LWALPSTQDLVNGPNASKFYLMDSTPYFMENFTRITSPNYRPTQQDILRSRQMTSGIFD
FT                   TVIDMGSDIKMHIYDVGGQRSERKKWIHCFDNVTLVIFCVSLSEYDQTLMEDKNQNRFQ
FT                   ESLVLFDNIVNSRWFARTSVVLFLNKIDLFAEKLSKVPMENYFPDYTGGSDINKAAKYI
FT                   LWRFVQLNRANLSIYPHVTQATDTSNIRLVFAAIKETILENTLKDSGVLQ"
FT   gene            196948..198519
FT                   /gene="RPN3"
FT                   /gene_synonym="SUN2"
FT                   /locus_tag="YER021W"
FT   mRNA            196948..198519
FT                   /gene="RPN3"
FT                   /gene_synonym="SUN2"
FT                   /locus_tag="YER021W"
FT                   /product="proteasome regulatory particle lid subunit RPN3"
FT   CDS_pept        196948..198519
FT                   /codon_start=1
FT                   /gene="RPN3"
FT                   /gene_synonym="SUN2"
FT                   /locus_tag="YER021W"
FT                   /product="proteasome regulatory particle lid subunit RPN3"
FT                   /note="Essential non-ATPase regulatory subunit of the 26S
FT                   proteasome lid; similar to the p58 subunit of the human 26S
FT                   proteasome; temperature-sensitive alleles cause metaphase
FT                   arrest, suggesting a role for the proteasome in cell cycle
FT                   control"
FT                   /db_xref="GOA:P40016"
FT                   /db_xref="InterPro:IPR000717"
FT                   /db_xref="InterPro:IPR013586"
FT                   /db_xref="InterPro:IPR035267"
FT                   /db_xref="InterPro:IPR036390"
FT                   /db_xref="PDB:3J47"
FT                   /db_xref="PDB:3JCK"
FT                   /db_xref="PDB:3JCO"
FT                   /db_xref="PDB:3JCP"
FT                   /db_xref="PDB:4CR2"
FT                   /db_xref="PDB:4CR3"
FT                   /db_xref="PDB:4CR4"
FT                   /db_xref="PDB:5A5B"
FT                   /db_xref="PDB:5MPB"
FT                   /db_xref="PDB:5MPC"
FT                   /db_xref="PDB:5MPD"
FT                   /db_xref="PDB:5MPE"
FT                   /db_xref="PDB:5WVI"
FT                   /db_xref="PDB:5WVK"
FT                   /db_xref="PDB:6FVT"
FT                   /db_xref="PDB:6FVU"
FT                   /db_xref="PDB:6FVV"
FT                   /db_xref="PDB:6FVW"
FT                   /db_xref="PDB:6FVX"
FT                   /db_xref="PDB:6FVY"
FT                   /db_xref="PDB:6J2C"
FT                   /db_xref="PDB:6J2N"
FT                   /db_xref="PDB:6J2Q"
FT                   /db_xref="PDB:6J2X"
FT                   /db_xref="PDB:6J30"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40016"
FT                   /experiment="EXISTENCE:direct assay:GO:0008541 proteasome
FT                   regulatory particle, lid subcomplex [PMID:9741626]"
FT                   /protein_id="DAA07674.1"
FT                   /translation="MASTAVMMDVDSSGVNDLHHSEKKYAEEDQVQELLKVLNEISKTT
FT                   LTLDPRYIWRSLKDLSSLRNQELLNAETLCFTVNVLYPDSSSFKKNLLKFITSNHKSSV
FT                   PGSAELRNSYPASFYSVNTEKKTIEVTAEINCFMHLLVQLFLWDSKELEQLVEFNRKVV
FT                   IPNLLCYYNLRSLNLINAKLWFYIYLSHETLARSSEEINSDNQNIILRSTMMKFLKIAS
FT                   LKHDNETKAMLINLILRDFLNNGEVDSASDFISKLEYPHTDVSSSLEARYFFYLSKINA
FT                   IQLDYSTANEYIIAAIRKAPHNSKSLGFLQQSNKLHCCIQLLMGDIPELSFFHQSNMQK
FT                   SLLPYYHLTKAVKLGDLKKFTSTITKYKQLLLKDDTYQLCVRLRSNVIKTGIRIISLTY
FT                   KKISLRDICLKLNLDSEQTVEYMVSRAIRDGVIEAKINHEDGFIETTELLNIYDSEDPQ
FT                   QVFDERIKFANQLHDEYLVSMRYPEDKKTQQNEKSENGENDDDTLDGDLMDDMSDISDL
FT                   DDLGFL"
FT   gene            198812..200875
FT                   /gene="SRB4"
FT                   /gene_synonym="MED17"
FT                   /locus_tag="YER022W"
FT   mRNA            198812..200875
FT                   /gene="SRB4"
FT                   /gene_synonym="MED17"
FT                   /locus_tag="YER022W"
FT                   /product="Srb4p"
FT   CDS_pept        198812..200875
FT                   /codon_start=1
FT                   /gene="SRB4"
FT                   /gene_synonym="MED17"
FT                   /locus_tag="YER022W"
FT                   /product="Srb4p"
FT                   /note="Subunit of the RNA polymerase II mediator complex;
FT                   associates with core polymerase subunits to form the RNA
FT                   polymerase II holoenzyme; required for basal RNA polymerase
FT                   II transcription; homozygosity of the human MED17 L371P
FT                   mutation is associated with infantile cerebral and
FT                   cerebellar atrophy with poor myelination"
FT                   /db_xref="GOA:P32569"
FT                   /db_xref="InterPro:IPR019313"
FT                   /db_xref="PDB:3J1O"
FT                   /db_xref="PDB:3RJ1"
FT                   /db_xref="PDB:4GWP"
FT                   /db_xref="PDB:4GWQ"
FT                   /db_xref="PDB:4H62"
FT                   /db_xref="PDB:4V1O"
FT                   /db_xref="PDB:5OQM"
FT                   /db_xref="PDB:5SVA"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32569"
FT                   /experiment="EXISTENCE:direct assay:GO:0000979 RNA
FT                   polymerase II core promoter sequence-specific DNA binding
FT                   [PMID:23447536]"
FT                   /experiment="EXISTENCE:direct assay:GO:0033613 activating
FT                   transcription factor binding [PMID:9660972]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045944 positive
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:8187178]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070847 core
FT                   mediator complex [PMID:9891034]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001139 RNA
FT                   polymerase II complex recruiting activity [PMID:19805365]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006367
FT                   transcription initiation from RNA polymerase II promoter
FT                   [PMID:16263706]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0001139 RNA
FT                   polymerase II complex recruiting activity [PMID:21415355]"
FT                   /protein_id="DAA07675.1"
FT                   /translation="MTTEDPDSNHLSSETGIKLALDPNLITLALSSNPNSSLHSPTSDE
FT                   PVPESAGKADTSIRLEGDELENKTKKDNDKNLKFLKNKDSLVSNPHEIYGSMPLEQLIP
FT                   IILRQRGPGFKFVDLNEKELQNEIKQLGSDSSDGHNSEKKDTDGADENVQIGEDFMEVD
FT                   YEDKDNPVDSRNETDHKTNENGETDDNIETVMTQEQFVKRRRDMLEHINLAMNESSLAL
FT                   EFVSLLLSSVKESTGMSSMSPFLRKVVKPSSLNSDKIPYVAPTKKEYIELDILNKGWKL
FT                   QSLNESKDLLRASFNKLSSILQNEHDYWNKIMQSISNKDVIFKIRDRTSGQKLLAIKYG
FT                   YEDSGSTYKHDRGIANIRNNIESQNLDLIPHSSSVFKGTDFVHSVKKFLRVRIFTKIES
FT                   EDDYILSGESVMDRDSESEEAETKDIRKQIQLLKKIIFEKELMYQIKKECALLISYGVS
FT                   IENENKVIIELPNEKFEIELLSLDDDSIVNHEQDLPKINDKRANLMLVMLRLLLVVIFK
FT                   KTLRSRISSPHGLINLNVDDDILIIRPILGKVRFANYKLLLKKIIKDYVLDIVPGSSIT
FT                   ETEVEREQPQENKNIDDENITKLNKEIRAFDKLLNIPRRELKINLPLTEHKSPNLSLML
FT                   ESPNYCNALIHIKFSAGTEANAVSFDTTFSDFKEVEDFLHFIVAEYIQQKKV"
FT   gene            201076..201936
FT                   /gene="PRO3"
FT                   /gene_synonym="ORE2"
FT                   /locus_tag="YER023W"
FT   mRNA            201076..201936
FT                   /gene="PRO3"
FT                   /gene_synonym="ORE2"
FT                   /locus_tag="YER023W"
FT                   /product="pyrroline-5-carboxylate reductase"
FT   CDS_pept        201076..201936
FT                   /codon_start=1
FT                   /gene="PRO3"
FT                   /gene_synonym="ORE2"
FT                   /locus_tag="YER023W"
FT                   /product="pyrroline-5-carboxylate reductase"
FT                   /EC_number="1.5.1.2"
FT                   /note="Delta 1-pyrroline-5-carboxylate reductase; catalyzes
FT                   the last step in proline biosynthesis"
FT                   /db_xref="GOA:P32263"
FT                   /db_xref="InterPro:IPR000304"
FT                   /db_xref="InterPro:IPR008927"
FT                   /db_xref="InterPro:IPR028939"
FT                   /db_xref="InterPro:IPR029036"
FT                   /db_xref="InterPro:IPR036291"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32263"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:7009582]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004735
FT                   pyrroline-5-carboxylate reductase activity
FT                   [PMID:1508147|PMID:2824433]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006561 proline
FT                   biosynthetic process [PMID:1508147|PMID:2824433]"
FT                   /protein_id="DAA07676.1"
FT                   /translation="MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNH
FT                   DEPSAQQVTDLVETFDESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKS
FT                   VIGGKLLISLAAGWTIDQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVN
FT                   ELISQVGKYVELPEKNMDAATALVGSGPAFVLLMLESLMESGLKLGIPLQESKECAMKV
FT                   LEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQL
FT                   GQKKK"
FT   gene            202192..204963
FT                   /gene="YAT2"
FT                   /locus_tag="YER024W"
FT   mRNA            202192..204963
FT                   /gene="YAT2"
FT                   /locus_tag="YER024W"
FT                   /product="carnitine O-acetyltransferase YAT2"
FT   CDS_pept        202192..204963
FT                   /codon_start=1
FT                   /gene="YAT2"
FT                   /locus_tag="YER024W"
FT                   /product="carnitine O-acetyltransferase YAT2"
FT                   /EC_number="2.3.1.7"
FT                   /note="Carnitine acetyltransferase; has similarity to
FT                   Yat1p, which is a carnitine acetyltransferase associated
FT                   with the mitochondrial outer membrane"
FT                   /db_xref="GOA:P40017"
FT                   /db_xref="InterPro:IPR000542"
FT                   /db_xref="InterPro:IPR039551"
FT                   /db_xref="InterPro:IPR042231"
FT                   /db_xref="InterPro:IPR042232"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40017"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:18427809]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004092
FT                   carnitine O-acetyltransferase activity [PMID:11329169]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006066 alcohol
FT                   metabolic process [PMID:11329169]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009437
FT                   carnitine metabolic process [PMID:11329169]"
FT                   /protein_id="DAA07677.1"
FT                   /translation="MSSGSTIVSSDKSGRTFKHEEELPKLPLPKLCDTLQRLKESLEPL
FT                   YYADGYYQHPLDPEQIEKLSSIIRDFEENPVSEKLQSKLQSYHDTRDCYLDELHLDINN
FT                   QTSTREIQDDVLPRNPFLVLADDALPNITQADRSAVLVHSAARFISALKQDLLPPDINA
FT                   TNGKPLSMAPFLNLFGTTRSPVFQRGEVENFDLNKPYTASDLEDPDYSSDEDDNDEPTQ
FT                   KDFDDRKRKHEEDIFTGNGITIKRHPDSKHILIISRGQYYTLEVLDSTNKIIYTAAELT
FT                   TIFNHIIKDSSGIEKSTALGSLTSHSFRNWKYARKRLQKRYPNELHRIDSALFVLVLDE
FT                   SQEETTNDGDDTADISQMFNRTITERDKKCTSANCKRVFYGTSIINSKGHQVGSCVSRW
FT                   YDKLQLVVTADAKATVIWDSFTCDGSVVLRFTSEIYTESVLRLARDVNAGDPQFSLWPN
FT                   VTQMDPETKKLMTATISADGGGPSEIDPKLVVNKIDWSFSNILNTHVHLSETKLADLIS
FT                   KYDIVRASIPLGRRSAQRLGVKPDSMVQVALQIAHYALYGRMVFGLEPVSTRGFKNSRS
FT                   SFINIQSQALLELCQLFISSSIDGTDKLDKFIQTCETHNNMVKHAKSGVGYEKHFNALK
FT                   YLFKFHDHFGIHLSGDESSAAKDLFENPLVLPFSQPELIVANCGNAATTTFGITPAVPH
FT                   GFGIGYIIKDDQVDLTVTSQFRQGDRLMFMLSWVLGEIRSYWRMSRGTSHNKTGVKISP
FT                   VVDKLYEMDNAVNNPPKRNGHTVNGSRKTSSSSQVNLNRYGGFFDLEGHIDSRNISKTP
FT                   SMKNLQKTFNGLTMSADNDHSSSAVSVPTEKEKLNTGHEILQIQPREVASNGLEADDET
FT                   DIEIVAGNADGTSSSASSATSLNSKKRNVINSRFDIDFDRSRVGRKVATLDQ"
FT   gene            205251..206834
FT                   /gene="GCD11"
FT                   /gene_synonym="SUI4"
FT                   /locus_tag="YER025W"
FT   mRNA            205251..206834
FT                   /gene="GCD11"
FT                   /gene_synonym="SUI4"
FT                   /locus_tag="YER025W"
FT                   /product="translation initiation factor eIF2 subunit gamma"
FT   CDS_pept        205251..206834
FT                   /codon_start=1
FT                   /gene="GCD11"
FT                   /gene_synonym="SUI4"
FT                   /locus_tag="YER025W"
FT                   /product="translation initiation factor eIF2 subunit gamma"
FT                   /note="Gamma subunit of the translation initiation factor
FT                   eIF2; involved in the identification of the start codon;
FT                   binds GTP when forming the ternary complex with GTP and
FT                   tRNAi-Met; mutations in human ortholog cause X-linked
FT                   intellectual disability (XLID)"
FT                   /db_xref="GOA:P32481"
FT                   /db_xref="InterPro:IPR000795"
FT                   /db_xref="InterPro:IPR004161"
FT                   /db_xref="InterPro:IPR009000"
FT                   /db_xref="InterPro:IPR009001"
FT                   /db_xref="InterPro:IPR015256"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="PDB:3J81"
FT                   /db_xref="PDB:3JAP"
FT                   /db_xref="PDB:3JAQ"
FT                   /db_xref="PDB:4ZGN"
FT                   /db_xref="PDB:4ZGQ"
FT                   /db_xref="PDB:6FYX"
FT                   /db_xref="PDB:6FYY"
FT                   /db_xref="PDB:6GSN"
FT                   /db_xref="PDB:6I3M"
FT                   /db_xref="PDB:6I7T"
FT                   /db_xref="PDB:6QG0"
FT                   /db_xref="PDB:6QG1"
FT                   /db_xref="PDB:6QG2"
FT                   /db_xref="PDB:6QG3"
FT                   /db_xref="PDB:6QG5"
FT                   /db_xref="PDB:6QG6"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32481"
FT                   /experiment="EXISTENCE:direct assay:GO:0001731 formation of
FT                   translation preinitiation complex [PMID:12008673]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic
FT                   43S preinitiation complex [PMID:12008673]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031369 translation
FT                   initiation factor binding [PMID:22683627]"
FT                   /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic
FT                   48S preinitiation complex [PMID:17242201]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF
FT                   complex [PMID:11018020|PMID:15838098]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000049 tRNA
FT                   binding [PMID:8947054]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003743
FT                   translation initiation factor activity [PMID:23063529]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005525 GTP
FT                   binding [PMID:8947054]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005850
FT                   eukaryotic translation initiation factor 2 complex
FT                   [PMID:8417348]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006413
FT                   translational initiation [PMID:23063529]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045903 positive
FT                   regulation of translational fidelity [PMID:9308967]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005515
FT                   protein binding [PMID:22683627]"
FT                   /protein_id="DAA07678.1"
FT                   /translation="MSDLQDQEPSIIINGNLEPVGEPDIVEETEVVAQETQETQDADKP
FT                   KKKVAFTGLEEDGETEEEKRKREFEEGGGLPEQPLNPDFSKLNPLSAEIINRQATINIG
FT                   TIGHVAHGKSTVVRAISGVQTVRFKDELERNITIKLGYANAKIYKCQEPTCPEPDCYRS
FT                   FKSDKEISPKCQRPGCPGRYKLVRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNE
FT                   SCPQPQTSEHLAAIEIMKLKHVIILQNKVDLMREESALEHQKSILKFIRGTIADGAPIV
FT                   PISAQLKYNIDAVNEFIVKTIPVPPRDFMISPRLIVIRSFDVNKPGAEIEDLKGGVAGG
FT                   SILNGVFKLGDEIEIRPGIVTKDDKGKIQCKPIFSNIVSLFAEQNDLKFAVPGGLIGVG
FT                   TKVDPTLCRADRLVGQVVGAKGHLPNIYTDIEINYFLLRRLLGVKTDGQKQAKVRKLEP
FT                   NEVLMVNIGSTATGARVVAVKADMARLQLTSPACTEINEKIALSRRIEKHWRLIGWATI
FT                   KKGTTLEPIA"
FT   gene            207357..207428
FT                   /locus_tag="tH(GUG)E1"
FT   tRNA            207357..207428
FT                   /locus_tag="tH(GUG)E1"
FT                   /product="tRNA-His"
FT                   /note="tH(GUG)E1; Histidine tRNA (tRNA-His), predicted by
FT                   tRNAscan-SE analysis"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030371 translation
FT                   repressor activity [PMID:27609601]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043022 ribosome
FT                   binding [PMID:27609601]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043555 regulation
FT                   of translation in response to stress [PMID:27609601]"
FT   gene            complement(207644..208474)
FT                   /gene="CHO1"
FT                   /gene_synonym="PSS1"
FT                   /locus_tag="YER026C"
FT   mRNA            complement(207644..208474)
FT                   /gene="CHO1"
FT                   /gene_synonym="PSS1"
FT                   /locus_tag="YER026C"
FT                   /product="CDP-diacylglycerol-serine
FT                   O-phosphatidyltransferase"
FT   CDS_pept        complement(207644..208474)
FT                   /codon_start=1
FT                   /gene="CHO1"
FT                   /gene_synonym="PSS1"
FT                   /locus_tag="YER026C"
FT                   /product="CDP-diacylglycerol-serine
FT                   O-phosphatidyltransferase"
FT                   /EC_number="2.7.8.8"
FT                   /note="Phosphatidylserine synthase; functions in
FT                   phospholipid biosynthesis; catalyzes the reaction
FT                   CDP-diaclyglycerol + L-serine = CMP +
FT                   L-1-phosphatidylserine, transcriptionally repressed by
FT                   myo-inositol and choline"
FT                   /db_xref="GOA:P08456"
FT                   /db_xref="InterPro:IPR000462"
FT                   /db_xref="InterPro:IPR004533"
FT                   /db_xref="InterPro:IPR016271"
FT                   /db_xref="UniProtKB/Swiss-Prot:P08456"
FT                   /experiment="EXISTENCE:direct assay:GO:0003882
FT                   CDP-diacylglycerol-serine O-phosphatidyltransferase
FT                   activity [PMID:6088519]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005741
FT                   mitochondrial outer membrane [PMID:3005242]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006659
FT                   phosphatidylserine biosynthetic process [PMID:6088519]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016021 integral
FT                   component of membrane [PMID:6274497]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003882
FT                   CDP-diacylglycerol-serine O-phosphatidyltransferase
FT                   activity [PMID:6988386]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006659
FT                   phosphatidylserine biosynthetic process [PMID:6988386]"
FT                   /protein_id="DAA07679.1"
FT                   /translation="MVESDEDFAPQEFPHTDTDVIVNEHRDENDGYASDEVGGTLSRRA
FT                   SSIFSINTTPLAPPNATDIQKFTSDEHHFSMMRNLHMADYITMLNGFSGFYSIVSCLRF
FT                   TLTGKPHYVQRAHFFILLGMCFDFLDGRVARLRNRSSLMGQELDSLADLVSFGVAPAAI
FT                   AFAIGFQTTFDVMILSFFVLCGLARLARFNVTVAQLPKDSSTGKSKYFEGLPMPTTLAL
FT                   VLGMAYCVRKGLIFDNIPFGIFREDQILEFHPIILVFFIHGCGMISKSLKIPKP"
FT   gene            complement(208979..210232)
FT                   /gene="GAL83"
FT                   /gene_synonym="SPM1"
FT                   /locus_tag="YER027C"
FT   mRNA            complement(208979..210232)
FT                   /gene="GAL83"
FT                   /gene_synonym="SPM1"
FT                   /locus_tag="YER027C"
FT                   /product="Gal83p"
FT   CDS_pept        complement(208979..210232)
FT                   /codon_start=1
FT                   /gene="GAL83"
FT                   /gene_synonym="SPM1"
FT                   /locus_tag="YER027C"
FT                   /product="Gal83p"
FT                   /note="One of three possible beta-subunits of the Snf1
FT                   kinase complex; allows nuclear localization of the Snf1
FT                   kinase complex in the presence of a nonfermentable carbon
FT                   source; necessary and sufficient for phosphorylation of the
FT                   Mig2p transcription factor in response to alkaline stress;
FT                   functionally redundant with SIP1 and SIP2 for the
FT                   phosphorylation of Mig1p in response to glucose
FT                   deprivation; contains a glycogen-binding domain"
FT                   /db_xref="GOA:Q04739"
FT                   /db_xref="InterPro:IPR006828"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="InterPro:IPR014756"
FT                   /db_xref="InterPro:IPR030077"
FT                   /db_xref="InterPro:IPR032640"
FT                   /db_xref="InterPro:IPR037256"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q04739"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:11331606|PMID:17237508]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005641 nuclear
FT                   envelope lumen [PMID:17237508]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:17237508]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031588
FT                   nucleotide-activated protein kinase complex
FT                   [PMID:12393914]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0004679
FT                   AMP-activated protein kinase activity [PMID:10990457]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006468
FT                   protein phosphorylation [PMID:10990457|PMID:27592031]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007165
FT                   signal transduction [PMID:10990457]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0043254
FT                   regulation of protein complex assembly [PMID:9121458]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:2000222
FT                   positive regulation of pseudohyphal growth [PMID:16980405]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive
FT                   growth in response to glucose limitation [PMID:12556493]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004679
FT                   AMP-activated protein kinase activity [PMID:7813428]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006468 protein
FT                   phosphorylation [PMID:27592031]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007155 cell
FT                   adhesion [PMID:12556493]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031588
FT                   nucleotide-activated protein kinase complex
FT                   [PMID:7813428|PMID:9121458]"
FT                   /protein_id="DAA07680.1"
FT                   /translation="MAGDNPENKDASMLDVSDAASNTTINGKHSADSTNEASLAYTFSQ
FT                   MNVDNPNELEPQHPLRHKSSLIFNDDDDDEIPPYSNHAENGSGETFDSDDDIDASSSSS
FT                   IDSNEGDIHDADMTGNTLQKMDYQPSQQPDSLQNQGFQQQQEQQQGTVEGKKGRAMMFP
FT                   VDITWQQGGNKVYVTGSFTGWRKMIGLVPVPGQPGLMHVKLQLPPGTHRFRFIVDNELR
FT                   FSDYLPTATDQMGNFVNYMEVSAPPDWGNEPQQHLAEKKANHVDDSKLSKRPMSARSRI
FT                   ALEIEKEPDDMGDGYTRFHDETPAKPNLEYTQDIPAVFTDPNVMEQYYLTLDQQQNNHQ
FT                   NMAWLTPPQLPPHLENVILNSYSNAQTDNTSGALPIPNHVILNHLATSSIKHNTLCVAS
FT                   IVRYKQKYVTQILYTPLQ"
FT   gene            complement(210692..211876)
FT                   /gene="MIG3"
FT                   /locus_tag="YER028C"
FT   mRNA            complement(210692..211876)
FT                   /gene="MIG3"
FT                   /locus_tag="YER028C"
FT                   /product="Mig3p"
FT   CDS_pept        complement(210692..211876)
FT                   /codon_start=1
FT                   /gene="MIG3"
FT                   /locus_tag="YER028C"
FT                   /product="Mig3p"
FT                   /note="Transcriptional regulator; partially nonfunctional
FT                   in S288C strains but has a major role in catabolite
FT                   repression and ethanol response in some other strains;
FT                   involved in response to toxic agents; phosphorylation by
FT                   Snf1p or the Mec1p pathway inactivates Mig3p, allowing
FT                   induction of damage response genes"
FT                   /db_xref="GOA:P39943"
FT                   /db_xref="InterPro:IPR013087"
FT                   /db_xref="InterPro:IPR036236"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39943"
FT                   /experiment="EXISTENCE:direct assay:GO:0000790 nuclear
FT                   chromatin [PMID:19680226]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000978 RNA
FT                   polymerase II proximal promoter sequence-specific DNA
FT                   binding [PMID:12239282|PMID:9832517]"
FT                   /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding
FT                   transcription repressor activity, RNA polymerase
FT                   II-specific [PMID:9832517]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043565
FT                   sequence-specific DNA binding [PMID:19158363]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0001227
FT                   DNA-binding transcription repressor activity, RNA
FT                   polymerase II-specific [PMID:9832517]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006974
FT                   cellular response to DNA damage stimulus [PMID:14993292]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0010768
FT                   negative regulation of transcription from RNA polymerase II
FT                   promoter in response to UV-induced DNA damage
FT                   [PMID:19680226]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0034644
FT                   cellular response to UV [PMID:19680226]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000430
FT                   regulation of transcription from RNA polymerase II promoter
FT                   by glucose [PMID:23275883]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010768 negative
FT                   regulation of transcription from RNA polymerase II promoter
FT                   in response to UV-induced DNA damage [PMID:19680226]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045471 response
FT                   to ethanol [PMID:23275883]"
FT                   /protein_id="DAA07681.1"
FT                   /translation="MNYLRDRFPPDNDQRPFRCEICSRGFHRLEHKKRHGRTHTGEKPH
FT                   KCTVQGCPKSFSRSDELKRHLRTHTKGVQRRRIKSKGSRKTVVNTATAAPTTFNENTGV
FT                   SLTGIGQSKVPPILISVAQNCDDVNIRNTGNNNGIVETQAPAILVPVINIPNDPHPIPS
FT                   SLSTTSITSIASVYPSTSPFQYLKSGFPEDPASTPYVHSSGSSLALGELSSNSSIFSKS
FT                   RRNLAAMSGPDSLSSSKNQSSASLLSQTSHPSKSFSRPPTDLSPLRRIMPSVNTGDMEI
FT                   SRTVSVSSSSSSLTSVTYDDTAAKDMGMGIFFDRPPVTQKACRSNHKYKVNAVSRGRQH
FT                   ERAQFHISGDDEDSNVHRQESRASNTSPNVSLPPIKSILRQIDNFNSAPSYFSK"
FT   rep_origin      212383..212631
FT                   /note="ARS512; Autonomously Replicating Sequence"
FT   gene            complement(212587..213177)
FT                   /gene="SMB1"
FT                   /locus_tag="YER029C"
FT   mRNA            complement(212587..213177)
FT                   /gene="SMB1"
FT                   /locus_tag="YER029C"
FT                   /product="mRNA splicing protein SMB1"
FT   CDS_pept        complement(212587..213177)
FT                   /codon_start=1
FT                   /gene="SMB1"
FT                   /locus_tag="YER029C"
FT                   /product="mRNA splicing protein SMB1"
FT                   /note="Core Sm protein Sm B; part of heteroheptameric
FT                   complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p)
FT                   that is part of the spliceosomal U1, U2, U4, and U5 snRNPs;
FT                   homolog of human Sm B and Sm B'"
FT                   /db_xref="GOA:P40018"
FT                   /db_xref="InterPro:IPR001163"
FT                   /db_xref="InterPro:IPR010920"
FT                   /db_xref="PDB:3JCM"
FT                   /db_xref="PDB:5GAM"
FT                   /db_xref="PDB:5GAN"
FT                   /db_xref="PDB:5GAO"
FT                   /db_xref="PDB:5GM6"
FT                   /db_xref="PDB:5GMK"
FT                   /db_xref="PDB:5LJ3"
FT                   /db_xref="PDB:5LJ5"
FT                   /db_xref="PDB:5LQW"
FT                   /db_xref="PDB:5MPS"
FT                   /db_xref="PDB:5MQ0"
FT                   /db_xref="PDB:5NRL"
FT                   /db_xref="PDB:5UZ5"
FT                   /db_xref="PDB:5WSG"
FT                   /db_xref="PDB:5Y88"
FT                   /db_xref="PDB:5YLZ"
FT                   /db_xref="PDB:5ZWM"
FT                   /db_xref="PDB:5ZWN"
FT                   /db_xref="PDB:5ZWO"
FT                   /db_xref="PDB:6BK8"
FT                   /db_xref="PDB:6EXN"
FT                   /db_xref="PDB:6G90"
FT                   /db_xref="PDB:6J6G"
FT                   /db_xref="PDB:6J6H"
FT                   /db_xref="PDB:6J6N"
FT                   /db_xref="PDB:6J6Q"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40018"
FT                   /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP
FT                   [PMID:11720284|PMID:11720285]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP
FT                   [PMID:9630245]"
FT                   /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5
FT                   tri-snRNP complex [PMID:10377396|PMID:10449419]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071004 U2-type
FT                   prespliceosome [PMID:16618970]"
FT                   /protein_id="DAA07682.1"
FT                   /translation="MSKIQVAHSSRLANLIDYKLRVLTQDGRVYIGQLMAFDKHMNLVL
FT                   NECIEERVPKTQLDKLRPRKDSKDGTTLNIKVEKRVLGLTILRGEQILSTVVEDKPLLS
FT                   KKERLVRDKKEKKQAQKQTKLRKEKEKKPGKIAKPNTANAKHTSSNSREIAQPSSSRYN
FT                   GGNDNIGANRSRFNNEAPPQTRKFQPPPGFKRK"
FT   gene            213437..213898
FT                   /gene="CHZ1"
FT                   /locus_tag="YER030W"
FT   mRNA            213437..213898
FT                   /gene="CHZ1"
FT                   /locus_tag="YER030W"
FT                   /product="Chz1p"
FT   CDS_pept        213437..213898
FT                   /codon_start=1
FT                   /gene="CHZ1"
FT                   /locus_tag="YER030W"
FT                   /product="Chz1p"
FT                   /note="Histone chaperone for Htz1p/H2A-H2B dimer; required
FT                   for the stabilization of the Chz1p-Htz1-H2B complex; has
FT                   overlapping function with Nap1p; null mutant displays weak
FT                   sensitivity to MMS and benomyl; contains a highly conserved
FT                   CHZ motif; protein abundance increases in response to DNA
FT                   replication stress"
FT                   /db_xref="GOA:P40019"
FT                   /db_xref="InterPro:IPR019098"
FT                   /db_xref="PDB:2JSS"
FT                   /db_xref="PDB:6AE8"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40019"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:17289584|PMID:14562095]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0006338
FT                   chromatin remodeling [PMID:17289584]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0042393
FT                   histone binding [PMID:17289584]"
FT                   /protein_id="DAA07683.1"
FT                   /translation="MSDEAKEKRELESQKESSHNKSEKSVEPKPKRRRRRNYDDYDAEV
FT                   AKEETKAKNGLTKSENNGTVEDSESDMDDAKLDALMGNEGEEEEDDLAEIDTSNIITSG
FT                   RRTRGKVIDYKKTAEELDKKEPSTGSKDDVGYGEKEEDDEDEEDDDFKE"
FT   gene            complement(214076..214747)
FT                   /gene="YPT31"
FT                   /gene_synonym="YPT8"
FT                   /locus_tag="YER031C"
FT   mRNA            complement(214076..214747)
FT                   /gene="YPT31"
FT                   /gene_synonym="YPT8"
FT                   /locus_tag="YER031C"
FT                   /product="Rab family GTPase YPT31"
FT   CDS_pept        complement(214076..214747)
FT                   /codon_start=1
FT                   /gene="YPT31"
FT                   /gene_synonym="YPT8"
FT                   /locus_tag="YER031C"
FT                   /product="Rab family GTPase YPT31"
FT                   /note="Rab family GTPase; involved in the exocytic pathway;
FT                   mediates intra-Golgi traffic or the budding of post-Golgi
FT                   vesicles from the trans-Golgi; YPT31 has a paralog, YPT32,
FT                   that arose from the whole genome duplication; localizes to
FT                   the transitional and late Golgi"
FT                   /db_xref="GOA:P38555"
FT                   /db_xref="InterPro:IPR001806"
FT                   /db_xref="InterPro:IPR005225"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="PDB:3CPJ"
FT                   /db_xref="UniProtKB/Swiss-Prot:P38555"
FT                   /experiment="EXISTENCE:direct assay:GO:0003924 GTPase
FT                   activity [PMID:11210571]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005741
FT                   mitochondrial outer membrane [PMID:16407407]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005768 endosome
FT                   [PMID:15537705]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005794 Golgi
FT                   apparatus [PMID:15537705]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi
FT                   network [PMID:26906739]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0034498 early
FT                   endosome to Golgi transport [PMID:15537705]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006887
FT                   exocytosis [PMID:9151665]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016192
FT                   vesicle-mediated transport [PMID:9151665]"
FT                   /protein_id="DAA07684.1"
FT                   /translation="MSSEDYGYDYDLLFKIVLIGDSGVGKSNLLSRFTKNEFNMDSKST
FT                   IGVEFATRTLEIDGKRIKAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSYENC
FT                   NHWLSELRENADDNVAVGLIGNKSDLAHLRAVPTEESKTFAQENQLLFTETSALNSENV
FT                   DKAFEELINTIYQKVSKHQMDLGDSSANGNANGASAPNGPTISLTPTPNENKKANGNNC
FT                   C"
FT   gene            215063..217693
FT                   /gene="FIR1"
FT                   /gene_synonym="PIP1"
FT                   /locus_tag="YER032W"
FT   mRNA            215063..217693
FT                   /gene="FIR1"
FT                   /gene_synonym="PIP1"
FT                   /locus_tag="YER032W"
FT                   /product="Fir1p"
FT   CDS_pept        215063..217693
FT                   /codon_start=1
FT                   /gene="FIR1"
FT                   /gene_synonym="PIP1"
FT                   /locus_tag="YER032W"
FT                   /product="Fir1p"
FT                   /note="Protein involved in 3' mRNA processing; interacts
FT                   with Ref2p; APCC(Cdh1) substrate; potential Cdc28p
FT                   substrate"
FT                   /db_xref="GOA:P40020"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40020"
FT                   /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud
FT                   neck [PMID:14562095]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0043631 RNA
FT                   polyadenylation [PMID:16788068]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006378 mRNA
FT                   polyadenylation [PMID:9196079]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043631 RNA
FT                   polyadenylation [PMID:16788068]"
FT                   /protein_id="DAA07685.1"
FT                   /translation="MSLPVTPVKSKVCSTLSIQHEMDHDQCRDVLCPRENLLAINRTNN
FT                   IESVAIPRQRSSKNKKPHEHTQSQVRFSIPDPNEISQDSPLKIVFPKSGNETERRMSTS
FT                   SLLMNSHGHLVDMHSKILVDVPKEVWKFHHNRRKKCESRHRKTRSDVRSNTSSSGKEPN
FT                   HSRSKSLQSIIVDTMNTYRATEVETSINENTSNISQVSPLNLSFDRPPPLTPEKNLYLT
FT                   PESPLNRYHLPVPLEISLPPYLSPQNKDKKRSSLVYDGDGYSQFQEGNTSSSTESSLEQ
FT                   PSSSYSDEDDSIPYAHHDVSFELNNADADKLLGIDENANVNLKIQRRNLKNPQHIKSKT
FT                   DRECEEKNTEKNVSLKILSTPNKLIDIPDLEHMKSPPSTGLNGTLKFFQQFEPSEEPTS
FT                   PTRQVNPESLDKLDMSFKFPSSTTNNNVDKVHENRNSGDTNNEDFLKVDTSPVNQSFES
FT                   RRQMLIDLQKSPTNNNPRIHKHRRSRSVHNIDDISLNFEATSTPPAPTSAPSIPVEHSN
FT                   PCTSIEIPKRSPLRFTSSPKTSDIPPEAQSPKNGSFLQEISVPSIQIIPDESISHTREP
FT                   SPSLIECPEDENEAFSTEVADHSIAIISETKSVPSIEPFKPLSSFNSFGQEIQNKEPTP
FT                   LNQTPTDLIGKQRNCVNPHSIPFSVLSSNSQSSQSGSSKSSYNSEFSSNTAITDTTSQP
FT                   SVTINRSTLEHNFIEEKRSIKNLGHGPPSQKNNYSFPRNKNTPSNRHDLDFNTIYEKRD
FT                   GKMVEVILLDEDEDVGLKNNDISRTRVCHAQKAKNEQQKKRLSHCNEILGMCDKTADDA
FT                   KRIIYQLVNEKHKFSEKGQQTKPKKSRVLPPLPFPLYDEKGNSLIPNKYQSSIHNDIPS
FT                   HRKLK"
FT   gene            complement(218057..221287)
FT                   /gene="ZRG8"
FT                   /locus_tag="YER033C"
FT   mRNA            complement(218057..221287)
FT                   /gene="ZRG8"
FT                   /locus_tag="YER033C"
FT                   /product="Zrg8p"
FT   CDS_pept        complement(218057..221287)
FT                   /codon_start=1
FT                   /gene="ZRG8"
FT                   /locus_tag="YER033C"
FT                   /product="Zrg8p"
FT                   /note="hypothetical protein; authentic, non-tagged protein
FT                   is detected in highly purified mitochondria in
FT                   high-throughput studies; GFP-fusion protein is localized to
FT                   the cytoplasm; transcription induced under conditions of
FT                   zinc deficiency"
FT                   /db_xref="GOA:P40021"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40021"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud
FT                   [PMID:15972461]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud
FT                   neck [PMID:15972461]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043332 mating
FT                   projection tip [PMID:15972461]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031505
FT                   fungal-type cell wall organization [PMID:15972461]"
FT                   /protein_id="DAA07686.1"
FT                   /translation="MRSFIKAHKKSTSFDESPKRHSNFSGNTNNSSQRSSDDSLDFLPS
FT                   TPSQMNYDSIPPPAKHSPGFESFHRLANKTSKLFKKTSNSNLNSHLASTPTTSTNQTTS
FT                   NSFVLQNPPTKNTGPPPPLPPPLFPSSSTSSFSRHDNESEYTAYKKTSPAKDFNRTTDS
FT                   LPAIKGTITHSWGDSKVESHVIILNDPASPASNTSEATSSKQFKTPIIGNENLTSTTSP
FT                   SNLEPAIRILNKNKGKQQENIDDAEDGSSKKEHHVYKALALAKNRNRQARIHSHDDIIN
FT                   LGKASQMDMSLLAAAFSGNSTTTINNDQSSNEQTDEKILDIERVTTTSTLTSSETTSPI
FT                   NKSPCFYSQTLSLSPKIRHGDLQSSPSKVNKNDSQNETLNKKKVRISLNRKEEEKVYSL
FT                   NNNSDEYSVNEKETHKANDCNDESSENGDGDNDHDDDYDDDDDDDDDDDESEFSFEYAG
FT                   INVRTSSVKYYSKPEPAANVYIDDLYEDENFDDDMNCIEDDESGNEGNEICGLSTRFEE
FT                   TSLKSNKVKKFNDLFNLSDDDEEEDGKDNSNNGDENESDNLYQKRLENGKETFNGNHGG
FT                   HHDDASLGETVDNKEQFLINDNVKKPIQKYNDLFDLSDEDDNDDKEMSEAESYMFSDEA
FT                   PSIESGPANAKSTRGIYSQSNKNIIRDGKPNYSFSLKRNNSDDETEHTSAIKASLTGTT
FT                   GSTKPTVKSFSDIFNVDDSASDAESDSGTGGNNSNGLVSNDSERQVSLQSSLYETKSES
FT                   HPPNHPHSQILQTPAKIVITPSVSDAQSQALAITDDDGEDDDDDTSSILRTPFQLIDSS
FT                   HSQQPHYASPQYTAVLNSPPLPPPARSQSLKYHDLNCDLDSEVPRPMSNLFFIDEAEED
FT                   EYNQKSKFFDFDHYDIDEINGIPEDFNFSDSERDDLNRRTLKSPLRGGSKNREVSPFSS
FT                   VSSSFRSTHSFNGKLTINQGAKELAPMKNKIELTNKTVTFFNSNNWNTYDCNSLSRKTS
FT                   SQMRDSKYQNHNVGQNVEPSSVLSPQHQISNGLDGKCNDNYVISPNLPTTITPTNSFTK
FT                   PTPEFSNDYSLSPIQETPSSVQSSPKRA"
FT   gene            221846..222403
FT                   /locus_tag="YER034W"
FT   mRNA            221846..222403
FT                   /locus_tag="YER034W"
FT                   /product="hypothetical protein"
FT   CDS_pept        221846..222403
FT                   /codon_start=1
FT                   /locus_tag="YER034W"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; non-essential gene; expression
FT                   induced upon calcium shortage; protein abundance increases
FT                   in response to DNA replication stress"
FT                   /db_xref="GOA:P40022"
FT                   /db_xref="InterPro:IPR035303"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40022"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /protein_id="DAA07687.1"
FT                   /translation="MDAFSLKKDNRKKFQDKQKLKRKHATPSDRKYRLLNRQKEEKATT
FT                   EEKDQDQEQPALKSNEDRYYEDPVLEDPHSAVANAELNKVLKDVLKNRLQQNDDATAVN
FT                   NVANKDTLKIKDLKQMNTDELNRWLGRQNTTSAITAAEPESLVVPIHVQGDHDRAGKKI
FT                   SAPSTDLPEELETDQDFLDGLL"
FT   gene            222639..223076
FT                   /gene="EDC2"
FT                   /locus_tag="YER035W"
FT   mRNA            222639..223076
FT                   /gene="EDC2"
FT                   /locus_tag="YER035W"
FT                   /product="Edc2p"
FT   CDS_pept        222639..223076
FT                   /codon_start=1
FT                   /gene="EDC2"
FT                   /locus_tag="YER035W"
FT                   /product="Edc2p"
FT                   /note="RNA-binding protein that directly activates mRNA
FT                   decapping; binds mRNA substrate and enhances activity of
FT                   decapping proteins Dcp1p and Dcp2p; has a role in
FT                   translation during heat stress; protein increases in
FT                   abundance and relocalizes to nucleolus and to nuclear foci
FT                   upon DNA replication stress; EDC2 has a paralog, EDC1, that
FT                   arose from the whole genome duplication"
FT                   /db_xref="GOA:P40023"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40023"
FT                   /experiment="EXISTENCE:direct assay:GO:0000290
FT                   deadenylation-dependent decapping of nuclear-transcribed
FT                   mRNA [PMID:12554867]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding
FT                   [PMID:12554867]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:19682251|PMID:14562095|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:19682251]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095|PMID:22842922]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032056 positive
FT                   regulation of translation in response to stress
FT                   [PMID:19682251]"
FT                   /protein_id="DAA07688.1"
FT                   /translation="MGSETKHSAKVKIVTRESPPSAKEHMRPTKTQILVPPTQSLPNGK
FT                   KPNFGKSTKQRREPRERTSKTGHEDDKATMVTVNIDAFLHDKAPKKKSCKYKKKKTRQY
FT                   QDRAAASIDSKPHVAGHTAFAGASFTTDIPHEAALPKPSFV"
FT   gene            complement(223367..225199)
FT                   /gene="ARB1"
FT                   /locus_tag="YER036C"
FT   mRNA            complement(223367..225199)
FT                   /gene="ARB1"
FT                   /locus_tag="YER036C"
FT                   /product="ATP-binding cassette family ATPase ARB1"
FT   CDS_pept        complement(223367..225199)
FT                   /codon_start=1
FT                   /gene="ARB1"
FT                   /locus_tag="YER036C"
FT                   /product="ATP-binding cassette family ATPase ARB1"
FT                   /note="ATPase of the ATP-binding cassette (ABC) family;
FT                   involved in 40S and 60S ribosome biogenesis, has similarity
FT                   to Gcn20p; shuttles from nucleus to cytoplasm, physically
FT                   interacts with Tif6p, Lsg1p; human homolog ABCF2 can
FT                   complement yeast ARB1 mutant"
FT                   /db_xref="GOA:P40024"
FT                   /db_xref="InterPro:IPR003439"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="InterPro:IPR017871"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR032781"
FT                   /db_xref="PDB:6R84"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40024"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:16260602]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000056
FT                   ribosomal small subunit export from nucleus
FT                   [PMID:16260602]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATPase
FT                   activity [PMID:16260602]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome
FT                   biogenesis [PMID:16260602]"
FT                   /protein_id="DAA07689.1"
FT                   /translation="MPPVSASKAKRDAKKAEREAKKAAAGKTIRKLGRKKEAAAEESEV
FT                   DAAAREIKMMKLQQDKDGLSDRVVTGVLSSLETSRDIKLSSVSLLFHGKVLIQDSGLEL
FT                   NYGRRYGLLGENGCGKSTFLKALATREYPIPEHIDIYLLDEPAEPSELSALDYVVTEAQ
FT                   HELKRIEDLVEKTILEDGPESELLEPLYERMDSLDPDTFESRAAIILIGLGFNKKTILK
FT                   KTKDMSGGWKMRVALAKALFVKPTLLLLDDPTAHLDLEACVWLEEYLKRFDRTLVLVSH
FT                   SQDFLNGVCTNMIDMRAQKLTAYGGNYDSYHKTRSELETNQMKQYNKQQEEIQHIKKFI
FT                   ASAGTYANLVKQAKSRQKILDKMEADGLVQPVVPDKVFSFRFPQVERLPPPVLAFDDIS
FT                   FHYESNPSENLYEHLNFGVDMDSRIALVGPNGVGKSTLLKIMTGELTPQSGRVSRHTHV
FT                   KLGVYSQHSQDQLDLTKSALEFVRDKYSNISQDFQFWRGQLGRYGLTGEGQTVQMATLS
FT                   EGQRSRVVFALLALEQPNVLLLDEPTNGLDIPTIDSLADAINEFNGGVVVVSHDFRLLD
FT                   KIAQDIFVVENKTATRWDGSILQYKNKLAKNVVL"
FT   gene            225889..226854
FT                   /gene="PHM8"
FT                   /locus_tag="YER037W"
FT   mRNA            225889..226854
FT                   /gene="PHM8"
FT                   /locus_tag="YER037W"
FT                   /product="bifunctional nucleotidase/lysophosphatidic acid
FT                   phosphatase"
FT   CDS_pept        225889..226854
FT                   /codon_start=1
FT                   /gene="PHM8"
FT                   /locus_tag="YER037W"
FT                   /product="bifunctional nucleotidase/lysophosphatidic acid
FT                   phosphatase"
FT                   /note="Lysophosphatidic acid (LPA) phosphatase,
FT                   nucleotidase; principle and physiological nucleotidase
FT                   working on GMP, UMP and CMP; involved in LPA hydrolysis in
FT                   response to phosphate starvation and ribose salvage
FT                   pathway; phosphatase activity is soluble and Mg2+
FT                   dependent; expression is induced by low phosphate levels
FT                   and by inactivation of Pho85p; repressed by Gcn4p under
FT                   normal conditions; PHM8 has a paralog, SDT1, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P40025"
FT                   /db_xref="InterPro:IPR006439"
FT                   /db_xref="InterPro:IPR010237"
FT                   /db_xref="InterPro:IPR023214"
FT                   /db_xref="InterPro:IPR036412"
FT                   /db_xref="InterPro:IPR041492"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40025"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008252 nucleotidase
FT                   activity [PMID:23670538]"
FT                   /experiment="EXISTENCE:direct assay:GO:0052642
FT                   lysophosphatidic acid phosphatase activity [PMID:18234677]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009166
FT                   nucleotide catabolic process [PMID:23670538]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016036 cellular
FT                   response to phosphate starvation [PMID:18234677]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0052642
FT                   lysophosphatidic acid phosphatase activity [PMID:18234677]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0070328
FT                   triglyceride homeostasis [PMID:26979516]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0090549 response
FT                   to carbon starvation [PMID:23670538]"
FT                   /protein_id="DAA07690.1"
FT                   /translation="MTIAKDYRTIYRNQIKKQIRLNQEHLQSLTHLGSQINFEVDPPKL
FT                   PDPDPARKVFFFDIDNTLYRKSTKVQLLMQQSLSNFFKYELGFDDDEAERLIESYYQEY
FT                   GLSVKGLIKNKQIDDVLQYNTFIDDSLPLQDYLKPDWKLRELLINLKKKKLGKFDKLWL
FT                   FTNSYKNHAIRCVKILGIADLFDGITYCHYDRPIEEEFICKPDPKFFETAKLQSGLSSF
FT                   ANAWFIDDNESNVRSALSMGMGHVIHLIEDYQYESENIVTKDHKNKQQFSILKDILEIP
FT                   LIMDVEVYRPSSIAIKEMEELEEEGEAVNWSNQQINVQSS"
FT   gene            complement(226858..228252)
FT                   /gene="KRE29"
FT                   /gene_synonym="NSE6"
FT                   /locus_tag="YER038C"
FT   mRNA            complement(226858..228252)
FT                   /gene="KRE29"
FT                   /gene_synonym="NSE6"
FT                   /locus_tag="YER038C"
FT                   /product="Smc5-Smc6 complex subunit KRE29"
FT   CDS_pept        complement(226858..228252)
FT                   /codon_start=1
FT                   /gene="KRE29"
FT                   /gene_synonym="NSE6"
FT                   /locus_tag="YER038C"
FT                   /product="Smc5-Smc6 complex subunit KRE29"
FT                   /note="Subunit of the SMC5-SMC6 complex; this complex is
FT                   involved in removal of X-shaped DNA structures that arise
FT                   between sister chromatids during DNA replication and
FT                   repair; heterozygous mutant shows haploinsufficiency in K1
FT                   killer toxin resistance"
FT                   /db_xref="GOA:P40026"
FT                   /db_xref="InterPro:IPR014803"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40026"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0019789 SUMO
FT                   transferase activity [PMID:15738391]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6
FT                   complex [PMID:15738391]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA
FT                   repair [PMID:15738391]"
FT                   /protein_id="DAA07691.1"
FT                   /translation="MGSVNSSPNEEFETVPDSQISGFDSPLIPTSVGSYFRDDDDDEKV
FT                   HPNFISDPENDSLNSDEEFSSLENSDLNLSGAKAESGDDFDPILKRTIISKRKAPSNNE
FT                   DEEIVKTPRKLVNYVPLKIFNLGDSFDDTITTTVAKLQDLKKEILDSPRSNKSIVITSN
FT                   TVAKSELQKSIKFSGSIPEIYLDVVTKETISDKYKDWHFISKNCHYEQLMDLEMKDTAY
FT                   SFLFGSSRSQGKVPEFVHLKCPSITNLLVLFGVNQEKCNSLKINYEKKENSRYDNLCTI
FT                   FPVNKMLKFLMYFYSDDDNDDVREFFLKAFICLILDRKVFNAMESDHRLCFKVLELFNE
FT                   AHFINSYFEIVDKNDFFLHYRLLQIFPHLQSALLRRRFSEKQGRTETIQQNIIKEFNEF
FT                   FDCKNYKNLLYFILTMYGSKFIPFGPKCQVTEYFKDCILDISNETTNDVEISILKGILN
FT                   LFSKIR"
FT   gene            228451..228831
FT                   /gene="FMP49"
FT                   /locus_tag="YER038W-A"
FT   mRNA            228451..228831
FT                   /gene="FMP49"
FT                   /locus_tag="YER038W-A"
FT                   /product="Fmp49p"
FT   CDS_pept        228451..228831
FT                   /codon_start=1
FT                   /gene="FMP49"
FT                   /locus_tag="YER038W-A"
FT                   /product="Fmp49p"
FT                   /note="Mitochondrial hypothetical protein; almost
FT                   completely overlaps ORF HVG1/YER039C"
FT                   /db_xref="GOA:A0A023PZB3"
FT                   /db_xref="UniProtKB/Swiss-Prot:A0A023PZB3"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /protein_id="DAA64607.1"
FT                   /translation="MYYFSRVAARTFCCCIFFCLATAYSRPDRNPRKIEKKDKKFFGAS
FT                   KNTNPANAMGNLFKAPTIEYVVEEVTRTHQPEQYDIPTDMSPLMTIAASESADKFTDKF
FT                   FVDQSSIMKEKTSSKGNARTLL"
FT   gene            complement(228456..229205)
FT                   /gene="HVG1"
FT                   /gene_synonym="YEM9"
FT                   /locus_tag="YER039C"
FT   mRNA            complement(228456..229205)
FT                   /gene="HVG1"
FT                   /gene_synonym="YEM9"
FT                   /locus_tag="YER039C"
FT                   /product="putative GDP-mannose transporter"
FT   CDS_pept        complement(228456..229205)
FT                   /codon_start=1
FT                   /gene="HVG1"
FT                   /gene_synonym="YEM9"
FT                   /locus_tag="YER039C"
FT                   /product="putative GDP-mannose transporter"
FT                   /note="hypothetical protein; HVG1 has a paralog, VRG4, that
FT                   arose from the whole genome duplication"
FT                   /db_xref="GOA:P0CE11"
FT                   /db_xref="InterPro:IPR000620"
FT                   /db_xref="InterPro:IPR038736"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CE11"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /protein_id="DAA07692.1"
FT                   /translation="MIYTSSKSLQYLAVPIYTIFKNLTIILIAYGEVLFFGGKVTSMEL
FT                   TSFIMMVLSSVVATWGDQQAIAIKASSLEDLDQELVESTIFVLNPGYLWMFTNCISSAL
FT                   FVLIMRKRIRLTNFKDYDTMFYNNVLALPLLLVFSFIMEDWSTKNLSVNLSADSLAAMV
FT                   ISGLMSVGISYCSGWCVRVTSSTTYSMVGALNKLPIALAGLVFFDAPKNFLSFFSIFLG
FT                   FLSGLLYAVAKQKKIQQQKVLAATLEK"
FT   gene            complement(229263..229481)
FT                   /locus_tag="YER039C-A"
FT   mRNA            complement(229263..229481)
FT                   /locus_tag="YER039C-A"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(229263..229481)
FT                   /codon_start=1
FT                   /locus_tag="YER039C-A"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; YER039C-A is not an essential
FT                   gene"
FT                   /db_xref="EnsemblGenomes-Gn:YER039C-A"
FT                   /db_xref="EnsemblGenomes-Tr:YER039C-A"
FT                   /db_xref="GOA:P0CD97"
FT                   /db_xref="InterPro:IPR038736"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CD97"
FT                   /protein_id="DAA07693.1"
FT                   /translation="MSKHKHEWTESVANSGPASILSYCASSILMTVTNKFVVNLDNFNM
FT                   NFVMLFVQSLVCTVTLCILRIVGVANF"
FT   gene            229795..231987
FT                   /gene="GLN3"
FT                   /locus_tag="YER040W"
FT   mRNA            229795..231987
FT                   /gene="GLN3"
FT                   /locus_tag="YER040W"
FT                   /product="nitrogen-responsive transcriptional regulator
FT                   GLN3"
FT   CDS_pept        229795..231987
FT                   /codon_start=1
FT                   /gene="GLN3"
FT                   /locus_tag="YER040W"
FT                   /product="nitrogen-responsive transcriptional regulator
FT                   GLN3"
FT                   /note="Transcriptional activator of genes regulated by
FT                   nitrogen catabolite repression; localization and activity
FT                   regulated by quality of nitrogen source and Ure2p"
FT                   /db_xref="GOA:P18494"
FT                   /db_xref="InterPro:IPR000679"
FT                   /db_xref="InterPro:IPR013088"
FT                   /db_xref="InterPro:IPR039355"
FT                   /db_xref="UniProtKB/Swiss-Prot:P18494"
FT                   /experiment="EXISTENCE:direct assay:GO:0000978 RNA
FT                   polymerase II proximal promoter sequence-specific DNA
FT                   binding [PMID:7608102]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding
FT                   transcription factor activity [PMID:8655543]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:10604478|PMID:27293098]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:12140287]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043565
FT                   sequence-specific DNA binding [PMID:19111667]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:26649943]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001080 nitrogen
FT                   catabolite activation of transcription from RNA polymerase
FT                   II promoter [PMID:7568152]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003700
FT                   DNA-binding transcription factor activity [PMID:8655543]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0036278 positive
FT                   regulation of transcription from RNA polymerase II promoter
FT                   in response to nitrogen starvation [PMID:26649943]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:2153652]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2001159
FT                   regulation of protein localization by the Cvt pathway
FT                   [PMID:26649943]"
FT                   /protein_id="DAA07694.1"
FT                   /translation="MQDDPENSKLYDLLNSHLDVHGRSNEEPRQTGDSRSQSSGNTGEN
FT                   EEDIAFASGLNGGTFDSMLEALPDDLYFTDFVSPFTAAATTSVTTKTVKDTTPATNHMD
FT                   DDIAMFDSLATTQPIDIAASNQQNGEIAQLWDFNVDQFNMTPSNSSGSATISAPNSFTS
FT                   DIPQYNHGSLGNSVSKSSLFPYNSSTSNSNINQPSINNNSNTNAQSHHSFNIYKLQNNN
FT                   SSSSAMNITNNNNSNNSNIQHPFLKKSDSIGLSSSNTTNSVRKNSLIKPMSSTSLANFK
FT                   RAASVSSSISNMEPSGQNKKPLIQCFNCKTFKTPLWRRSPEGNTLCNACGLFQKLHGTM
FT                   RPLSLKSDVIKKRISKKRAKQTDPNIAQNTPSAPATASTSVTTTNAKPIRSRKKSLQQN
FT                   SLSRVIPEEIIRDNIGNTNNILNVNRGGYNFNSVPSPVLMNSQSYNSSNANFNGASNAN
FT                   LNSNNLMRHNSNTVTPNFRRSSRRSSTSSNTSSSSKSSSRSVVPILPKPSPNSANSQQF
FT                   NMNMNLMNTTNNVSAGNSVASSPRIISSANFNSNSPLQQNLLSNSFQRQGMNIPRRKMS
FT                   RNASYSSSFMAASLQQLHEQQQVDVNSNTNTNSNRQNWNSSNSVSTNSRSSNFVSQKPN
FT                   FDIFNTPVDSPSVSRPSSRKSHTSLLSQQLQNSESNSFISNHKFNNRLSSDSTSPIKYE
FT                   ADVSAGGKISEDNSTKGSSKESSAIADELDWLKFGI"
FT   gene            232461..234740
FT                   /gene="YEN1"
FT                   /locus_tag="YER041W"
FT   mRNA            232461..234740
FT                   /gene="YEN1"
FT                   /locus_tag="YER041W"
FT                   /product="crossover junction endodeoxyribonuclease"
FT   CDS_pept        232461..234740
FT                   /codon_start=1
FT                   /gene="YEN1"
FT                   /locus_tag="YER041W"
FT                   /product="crossover junction endodeoxyribonuclease"
FT                   /note="Holliday junction resolvase; promotes template
FT                   switching during break-induced replication (BIR), causing
FT                   non-reciprocal translocations (NRTs); localization is
FT                   cell-cycle dependent and regulated by Cdc28p
FT                   phosphorylation; homolog of human GEN1; similar to S.
FT                   cerevisiae endonuclease Rth1p"
FT                   /db_xref="GOA:P40028"
FT                   /db_xref="InterPro:IPR006084"
FT                   /db_xref="InterPro:IPR006085"
FT                   /db_xref="InterPro:IPR006086"
FT                   /db_xref="InterPro:IPR029060"
FT                   /db_xref="InterPro:IPR036279"
FT                   /db_xref="InterPro:IPR037316"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40028"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:19520826]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:19520826]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008821 crossover
FT                   junction endodeoxyribonuclease activity [PMID:19020614]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA
FT                   repair [PMID:20106725]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006974
FT                   cellular response to DNA damage stimulus [PMID:20106725]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008821
FT                   crossover junction endodeoxyribonuclease activity
FT                   [PMID:19020614]"
FT                   /protein_id="DAA07695.2"
FT                   /translation="MGVSQIWEFLKPYLQDSRIPLRKFVIDFNKSQKRAPRIAIDAYGW
FT                   LFECGFIQNIDISARSRSRSRSPTRSPRDSDIDSSQEYYGSRSYTTTGKAVINFISRLK
FT                   ELLSLNVEFLLVFDGVMKPSFKRKFNHEQNATTCDDEKEYYSSWEQHVKNHEVYGNCKG
FT                   LLAPSDPEFISLVRKLLDLMNISYVIACGEGEAQCVWLQVSGAVDFILSNDSDTLVFGG
FT                   EKILKNYSKFYDDFGPSSITSHSPSRHHDSKESFVTVIDLPKINKVAGKKFDRLSLLFF
FT                   SVLLGADYNRGVKGLGKNKSLQLAQCEDPNFSMEFYDIFKDFNLEDLTSESLRKSRYRL
FT                   FQKRLYLYCKDHSVELFGRNYPVLLNQGSFEGWPSTVAIMHYFHPIVQPYFDEEVLSDK
FT                   YINMAGNGHYRNLNFNELKYFLQSLNLPQISSFDKWFHDSMHEMFLLREFLSIDESDNI
FT                   GKGNMRITEEKIMNIDGGKFQIPCFKIRYTTFLPNIPISSQSPLKRSNSPSRSKSPTRR
FT                   QMDIMEHPNSLWLPKYLIPQSHPLVIQYYETQQLIQKEKEKKGKKSNKSRLPQKNNLDE
FT                   FLRKHTSPIKSIGKVGESRKEILEPVRKRLFVDTDEDTSLEEIPAPTRLTTVDEHSDND
FT                   DDSLIFVDEITNSQSVLDSSPGKRIRDLTQDEQVDVWKDVIEISPIKKSRTTNAEKNPP
FT                   ESGLKSRSSITINARLQGTKMLPPNLTAPRLEREHSSVLDQLVTDAQDTVDRFVACDSD
FT                   SSSTIE"
FT   gene            234937..235491
FT                   /gene="MXR1"
FT                   /locus_tag="YER042W"
FT   mRNA            234937..235491
FT                   /gene="MXR1"
FT                   /locus_tag="YER042W"
FT                   /product="peptide-methionine-S-sulfoxide reductase"
FT   CDS_pept        234937..235491
FT                   /codon_start=1
FT                   /gene="MXR1"
FT                   /locus_tag="YER042W"
FT                   /product="peptide-methionine-S-sulfoxide reductase"
FT                   /EC_number="1.8.4.11"
FT                   /note="Methionine-S-sulfoxide reductase; involved in the
FT                   response to oxidative stress; protects iron-sulfur clusters
FT                   from oxidative inactivation along with MXR2; involved in
FT                   the regulation of lifespan; reduced activity of human
FT                   homolog implicated in Alzheimer disease"
FT                   /db_xref="GOA:P40029"
FT                   /db_xref="InterPro:IPR002569"
FT                   /db_xref="InterPro:IPR036509"
FT                   /db_xref="PDB:3PIL"
FT                   /db_xref="PDB:3PIM"
FT                   /db_xref="PDB:3PIN"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40029"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:20799725|PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008113
FT                   peptide-methionine (S)-S-oxide reductase activity
FT                   [PMID:15141092|PMID:9275166]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0034599
FT                   cellular response to oxidative stress [PMID:11929995]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008113
FT                   peptide-methionine (S)-S-oxide reductase activity
FT                   [PMID:15141092|PMID:9275166]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular
FT                   response to oxidative stress [PMID:11929995|PMID:9275166]"
FT                   /protein_id="DAA07696.1"
FT                   /translation="MSSLISKTIKYDPAKDKLITLACGCFWGTEHMYRKYLNDRIVDCK
FT                   VGYANGEESKKDSPSSVSYKRVCGGDTDFAEVLQVSYNPKVITLRELTDFFFRIHDPTT
FT                   SNSQGPDKGTQYRSGLFAHSDADLKELAKIKEEWQPKWGNKIATVIEPIKNFYDAEEYH
FT                   QLYLDKNPQGYACPTHYLREM"
FT   gene            complement(235770..237119)
FT                   /gene="SAH1"
FT                   /locus_tag="YER043C"
FT   mRNA            complement(235770..237119)
FT                   /gene="SAH1"
FT                   /locus_tag="YER043C"
FT                   /product="adenosylhomocysteinase"
FT   CDS_pept        complement(235770..237119)
FT                   /codon_start=1
FT                   /gene="SAH1"
FT                   /locus_tag="YER043C"
FT                   /product="adenosylhomocysteinase"
FT                   /EC_number="3.3.1.1"
FT                   /note="S-adenosyl-L-homocysteine hydrolase; catabolizes
FT                   S-adenosyl-L-homocysteine which is formed after donation of
FT                   the activated methyl group of S-adenosyl-L-methionine
FT                   (AdoMet) to an acceptor; regulates cellular lipid
FT                   homoeostasis by regulating phosphatidylcholine(PC)synthesis
FT                   and triacylglycerol (TG) levels"
FT                   /db_xref="GOA:P39954"
FT                   /db_xref="InterPro:IPR000043"
FT                   /db_xref="InterPro:IPR015878"
FT                   /db_xref="InterPro:IPR020082"
FT                   /db_xref="InterPro:IPR036291"
FT                   /db_xref="InterPro:IPR042172"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39954"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004013
FT                   adenosylhomocysteinase activity [PMID:18591246]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006641
FT                   triglyceride metabolic process [PMID:18591246]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006656
FT                   phosphatidylcholine biosynthetic process [PMID:18591246]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0019510
FT                   S-adenosylhomocysteine catabolic process [PMID:18591246]"
FT                   /protein_id="DAA07697.1"
FT                   /translation="MSAPAQNYKIADISLAAFGRKEIELAEHEMPGLMAIRKAYGDVQP
FT                   LKGARIAGCLHMTIQTAVLIETLVALGAEVTWSSCNIYSTQDHAAAAIAASGVPVFAWK
FT                   GETEEEYLWCIEQQLFAFKDNKKLNLILDDGGDLTTLVHEKHPEMLEDCFGLSEETTTG
FT                   VHHLYRMVKEGKLKVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVAVVA
FT                   GYGDVGKGCAAALRGMGARVLVTEIDPINALQAAMEGYQVVTMEDASHIGQVFVTTTGC
FT                   RDIINGEHFINMPEDAIVCNIGHFDIEIDVAWLKANAKECINIKPQVDRYLLSSGRHVI
FT                   LLANGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKSNDKSFREKHIEFQKTGPFEVG
FT                   VHVLPKILDEAVAKFHLGNLGVRLTKLSKVQSEYLGIPEEGPFKADHYRY"
FT   gene            complement(237570..238016)
FT                   /gene="ERG28"
FT                   /gene_synonym="BUD18"
FT                   /locus_tag="YER044C"
FT   mRNA            complement(237570..238016)
FT                   /gene="ERG28"
FT                   /gene_synonym="BUD18"
FT                   /locus_tag="YER044C"
FT                   /product="Erg28p"
FT   CDS_pept        complement(237570..238016)
FT                   /codon_start=1
FT                   /gene="ERG28"
FT                   /gene_synonym="BUD18"
FT                   /locus_tag="YER044C"
FT                   /product="Erg28p"
FT                   /note="Endoplasmic reticulum membrane protein; may
FT                   facilitate protein-protein interactions between the Erg26p
FT                   dehydrogenase and the Erg27p 3-ketoreductase and/or tether
FT                   these enzymes to the ER, also interacts with Erg6p"
FT                   /db_xref="GOA:P40030"
FT                   /db_xref="InterPro:IPR005352"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40030"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
FT                   reticulum membrane [PMID:12119386]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol
FT                   biosynthetic process [PMID:11160377]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006696
FT                   ergosterol biosynthetic process [PMID:10929718]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0070988
FT                   demethylation [PMID:29319811]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0030674
FT                   protein binding, bridging [PMID:12119386|PMID:15522820]"
FT                   /protein_id="DAA07698.1"
FT                   /translation="MFSLQDVITTTKTTLAAMPKGYLPKWLLFISIVSVFNSIQTYVSG
FT                   LELTRKVYERKPTETTHLSARTFGTWTFISCVIRFYGAMYLNEPHIFELVFMSYMVALF
FT                   HFGSELLIFRTCKLGKGFMGPLVVSTTSLVWMYKQREYYTGVAW"
FT   gene            complement(238460..239774)
FT                   /gene="MEI4"
FT                   /locus_tag="YER044C-A"
FT   mRNA            complement(join(238460..239623,239712..239774))
FT                   /gene="MEI4"
FT                   /locus_tag="YER044C-A"
FT                   /product="Mei4p"
FT   CDS_pept        complement(join(238460..239623,239712..239774))
FT                   /codon_start=1
FT                   /gene="MEI4"
FT                   /locus_tag="YER044C-A"
FT                   /product="Mei4p"
FT                   /note="Meiosis-specific protein involved in forming DSBs;
FT                   involved in double-strand break (DSBs) formation during
FT                   meiotic recombination; required for chromosome synapsis and
FT                   production of viable spores"
FT                   /db_xref="GOA:P29467"
FT                   /db_xref="InterPro:IPR025888"
FT                   /db_xref="UniProtKB/Swiss-Prot:P29467"
FT                   /experiment="EXISTENCE:direct assay:GO:0000794 condensed
FT                   nuclear chromosome [PMID:16783010|PMID:17558514]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0042138
FT                   meiotic DNA double-strand break formation [PMID:10224247]"
FT                   /protein_id="DAA07699.1"
FT                   /translation="MSRGKLEDMEQKETSEVDWIICFALIQSRNPTLWKRALSRKKGDV
FT                   EDVGALKSEKNLKINPRENSKHIYKWVAPFENGFLNNKSLFAHLEPIYNFLCQNKYKSF
FT                   EDAVGLKELQSFSKDVSTADINNWFLPRYKILLKILSLKTKEIDFRGLSQVFQTLQILL
FT                   VSHYSHRIDSDSSFKRTLIDVHVFNFIAKFLFNRILLKKNQNDPKWLQNFYDQGDGKHL
FT                   CDKVDYKRLCSLHFTLIYSIINIQLIKIKTNQTFEPQILKYVSVLKLIEHILIIIESLI
FT                   HVLIRFVSKHKLICINRKKAYCRVYLERELSLKKTYLKNFYSVISGVPEKELGGLLKIL
FT                   KIVILSLLETFESIEWQHLKPFLEKFPAHEISLQKKRKYIQAALLITAERNLIARFRLS
FT                   RWFNETENI"
FT   gene            complement(240032..241501)
FT                   /gene="ACA1"
FT                   /locus_tag="YER045C"
FT   mRNA            complement(240032..241501)
FT                   /gene="ACA1"
FT                   /locus_tag="YER045C"
FT                   /product="Aca1p"
FT   CDS_pept        complement(240032..241501)
FT                   /codon_start=1
FT                   /gene="ACA1"
FT                   /locus_tag="YER045C"
FT                   /product="Aca1p"
FT                   /note="ATF/CREB family basic leucine zipper (bZIP)
FT                   transcription factor; binds as a homodimer to the ATF/CREB
FT                   consensus sequence TGACGTCA; important for carbon source
FT                   utilization; target genes include GRE2 and COS8; ACA1 has a
FT                   paralog, CST6, that arose from the whole genome
FT                   duplication"
FT                   /db_xref="GOA:P39970"
FT                   /db_xref="InterPro:IPR004827"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39970"
FT                   /experiment="EXISTENCE:curator inference:GO:0005634 nucleus
FT                   [PMID:10825197]"
FT                   /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding
FT                   transcription activator activity, RNA polymerase
FT                   II-specific [PMID:10825197]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043565
FT                   sequence-specific DNA binding [PMID:10825197]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045944 positive
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:10825197]"
FT                   /protein_id="DAA07700.1"
FT                   /translation="MDYKHNFATSPDSFLDGRQNPLLYTDFLSSNKELIYKQPSGPGLV
FT                   DSAYNFHHQNSLHDRSVQENLGPMFQPFGVDISHLPITNPPIFQSSLPAFDQPVYKRRI
FT                   SISNGQISQLGEDLETVENLYNCQPPILSSKAQQNPNPQQVANPSAAIYPSFSSNELQN
FT                   VPQPHEQATVIPEAAPQTGSKNIYAAMTPYDSNIKLNIPAVAATCDIPSATPSIPSGDS
FT                   TMNQAYINMQLRLQAQMQTKAWKNAQLNVHPCTPASNSSVSSSSSCQNINDHNIENQSV
FT                   HSSISHGVNHHTVNNSCQNAELNISSSLPYESKCPDVNLTHANSKPQYKDATSALKNNI
FT                   NSEKDVHTAPFSSMHTTATFQIKQEARPQKIENNTAGLKDGAKAWKRARLLERNRIAAS
FT                   KCRQRKKMSQLQLQREFDQISKENTMMKKKIENYEKLVQKMKKISRLHMQECTINGGNN
FT                   SYQSLQNKDSDVNGFLKMIEEMIRSSSLYDE"
FT   gene            243180..243611
FT                   /gene="SPO73"
FT                   /locus_tag="YER046W"
FT   mRNA            243180..243611
FT                   /gene="SPO73"
FT                   /locus_tag="YER046W"
FT                   /product="Spo73p"
FT   CDS_pept        243180..243611
FT                   /codon_start=1
FT                   /gene="SPO73"
FT                   /locus_tag="YER046W"
FT                   /product="Spo73p"
FT                   /note="Meiosis-specific protein required for prospore
FT                   membrane morphogenesis; required for the proper shape of
FT                   the prospore membrane (PSM) and for spore wall formation;
FT                   functions cooperatively with SPO71 in PSM elongation;
FT                   physically interacts with Spo71p; genetically antagonistic
FT                   to SPO1, similar to SPO71; localizes to the PSM; required
FT                   for spore wall formation during sporulation; dispensable
FT                   for both nuclear divisions during meiosis; dysferlin
FT                   domain-only protein"
FT                   /db_xref="GOA:P40031"
FT                   /db_xref="InterPro:IPR006614"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40031"
FT                   /experiment="EXISTENCE:direct assay:GO:0005628 prospore
FT                   membrane [PMID:26605945|PMID:27303688]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:15590821]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030437
FT                   ascospore formation [PMID:11470404]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030476
FT                   ascospore wall assembly [PMID:15590821]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032120
FT                   ascospore-type prospore membrane assembly
FT                   [PMID:26605945|PMID:27303688]"
FT                   /protein_id="DAA07701.1"
FT                   /translation="MGKNHFLKDFSALPEDVLIENERGITLLGYPLFSPKILLPHVDPP
FT                   QFQRLNTENGSLIALSKNTISNFIELYPIDLSTERTAGSSSSQMTKWFVLMDYKEKYDI
FT                   DDQGWCYSWNFNNSRWKSKNGLVRRRVWVRLPTTSHGLD"
FT   gene            complement(243810..246503)
FT                   /gene="SAP1"
FT                   /locus_tag="YER047C"
FT   mRNA            complement(243810..246503)
FT                   /gene="SAP1"
FT                   /locus_tag="YER047C"
FT                   /product="putative AAA family ATPase SAP1"
FT   CDS_pept        complement(243810..246503)
FT                   /codon_start=1
FT                   /gene="SAP1"
FT                   /locus_tag="YER047C"
FT                   /product="putative AAA family ATPase SAP1"
FT                   /note="Putative ATPase of the AAA family; interacts with
FT                   the Sin1p transcriptional repressor in the two-hybrid
FT                   system"
FT                   /db_xref="GOA:P39955"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="InterPro:IPR003959"
FT                   /db_xref="InterPro:IPR003960"
FT                   /db_xref="InterPro:IPR015415"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR041569"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39955"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /protein_id="DAA07702.1"
FT                   /translation="MDSQRSHHILTRLTKIRRRPQQPLTDFTELYSRIANETIYYLNLE
FT                   EKKRYKEALQGWKALTTDVLFKQTLIEHNYPNTQSYTKDEVSLQNGIRELYHKSVMHLK
FT                   RVKKLVREEPAPRNDMPSSKTYTNHSSSFTRSTEPPPVFQMVPGRMMKTLRNRNACGYK
FT                   TAYSNPSLSSYGNSTSIKRGEDAENIRVNFVPSKPLSNNASRQHKNPIEHNDPPLKKET
FT                   ELYSDKYISEPILIDLTNDEDDHDVGILKGHNVFDEEESDGFEFDVSDYYDNFSEVDVE
FT                   EEEEEKEERRRIKTLEAIQQQMSDLSVTSSTSSNKSVSSSENVPGSCIQSLPTTAPALP
FT                   SLPPPPLLNVDRASSTGALKPHSLETSTTMDSSKIRNPQISKLMKNNHVPYLKGTKSTP
FT                   TLITKSTPTFITRSKSNTKPIIKSNASSPTSSLTVPNSVIQKPKTAAMAAKRVLNSKKV
FT                   ASNPALNTTKKSHPILKSKTAKVPNSSSKKTSSHPSRPVSNSKPYSHGASQNKKPSKNQ
FT                   TTSMSKTNRKIPAQKKIGSPKIEDVGTEDATEHATSLNEQREEPEIDKKVLREILEDEI
FT                   IDSLQGVDRQAAKQIFAEIVVHGDEVHWDDIAGLESAKYSLKEAVVYPFLRPDLFRGLR
FT                   EPVRGMLLFGPPGTGKTMLARAVATESHSTFFSISASSLTSKYLGESEKLVRALFAIAK
FT                   KLSPSIIFVDEIDSIMGSRNNENENESSRRIKNEFLVQWSSLSSAAAGSNKSNTNNSDT
FT                   NGDEDDTRVLVLAATNLPWSIDEAARRRFVRRQYIPLPEDQTRHVQFKKLLSHQKHTLT
FT                   ESDFDELVKITEGYSGSDITSLAKDAAMGPLRDLGDKLLETEREMIRPIGLVDFKNSLV
FT                   YIKPSVSQDGLVKYEKWASQFGSSGS"
FT   gene            complement(246982..248157)
FT                   /gene="CAJ1"
FT                   /locus_tag="YER048C"
FT   mRNA            complement(246982..248157)
FT                   /gene="CAJ1"
FT                   /locus_tag="YER048C"
FT                   /product="Caj1p"
FT   CDS_pept        complement(246982..248157)
FT                   /codon_start=1
FT                   /gene="CAJ1"
FT                   /locus_tag="YER048C"
FT                   /product="Caj1p"
FT                   /note="Nuclear type II J heat shock protein of the E. coli
FT                   dnaJ family; contains a leucine zipper-like motif, binds to
FT                   non-native substrates for presentation to Ssa3p, may
FT                   function during protein translocation, assembly and
FT                   disassembly"
FT                   /db_xref="GOA:P39101"
FT                   /db_xref="InterPro:IPR001623"
FT                   /db_xref="InterPro:IPR018253"
FT                   /db_xref="InterPro:IPR026894"
FT                   /db_xref="InterPro:IPR036869"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39101"
FT                   /protein_id="DAA07703.1"
FT                   /translation="MVKETEYYDILGIKPEATPTEIKKAYRRKAMETHPDKHPDDPDAQ
FT                   AKFQAVGEAYQVLSDPGLRSKYDQFGKEDAVPQQGFEDASEYFTAIFGGDGFKDWIGEF
FT                   SLFKELNEATEMFGKEDEEGTAATETEKADESTDGGMVKHDTNKAESLKKDKLSKEQRE
FT                   KLMEMEKKRREDMMKQVDELAEKLNEKISRYLIAVKSNNLEEFTRKLDQEIEDLKLESF
FT                   GLELLYLLARVYKTKANNFIMSKKTYGISKIFTGTRDNARSVKSAYNLLSTGLEAQKAM
FT                   EKMSEVNTDELDQYERAKFESTMAGKALGVMWAMSKFELERKLKDVCNKILNDKKVPSK
FT                   ERIAKAKAMLFIAHKFASARRSPEEAEEARVFEELILGEQEKEHKKHTVAR"
FT   repeat_region   complement(249109..249331)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   repeat_region   249445..249752
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   repeat_region   complement(249930..250270)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty3 LTR"
FT   gene            250286..250357
FT                   /locus_tag="tQ(UUG)E1"
FT   tRNA            250286..250357
FT                   /locus_tag="tQ(UUG)E1"
FT                   /product="tRNA-Gln"
FT                   /note="tQ(UUG)E1; Glutamine tRNA (tRNA-Gln), predicted by
FT                   tRNAscan-SE analysis; thiolation of uridine at wobble
FT                   position (34) requires Ncs6p"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:15706032]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:15706032]"
FT   gene            250718..251002
FT                   /gene="ISD11"
FT                   /locus_tag="YER048W-A"
FT   mRNA            250718..251002
FT                   /gene="ISD11"
FT                   /locus_tag="YER048W-A"
FT                   /product="Isd11p"
FT   CDS_pept        250718..251002
FT                   /codon_start=1
FT                   /gene="ISD11"
FT                   /locus_tag="YER048W-A"
FT                   /product="Isd11p"
FT                   /note="Cysteine desulfurase (Nfs1p) activator; essential
FT                   for the formation of the persulfide intermediate at the
FT                   desulfurase active site during pyridoxal
FT                   phosphate-dependent desulfuration of cysteine; required for
FT                   mitochondrial iron-sulfur cluster biosynthesis; exclusive
FT                   to eukaryotes, implicated as eukaryotic supplement to the
FT                   bacterium-derived Fe-S cluster (ISC) assembly apparatus;
FT                   involved in regulation of iron metabolism; member of the
FT                   LYR protein family"
FT                   /db_xref="GOA:Q6Q560"
FT                   /db_xref="InterPro:IPR008011"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q6Q560"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005759
FT                   mitochondrial matrix [PMID:16341089|PMID:16341090]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031071 cysteine
FT                   desulfurase activity [PMID:24045011]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031314 extrinsic
FT                   component of mitochondrial inner membrane [PMID:16341090]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016226
FT                   iron-sulfur cluster assembly [PMID:16341089|PMID:16341090]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0016226
FT                   iron-sulfur cluster assembly [PMID:16341090]"
FT                   /experiment="EXISTENCE:physical interaction:GO:1990221
FT                   L-cysteine desulfurase complex [PMID:24045011]"
FT                   /protein_id="DAA07704.1"
FT                   /translation="MPGFTAPTRRQVLSLYKEFIKNANQFNNYNFREYFLSKTRTTFRK
FT                   NMNQQDPKVLMNLFKEAKNDLGVLKRQSVISQMYTFDRLVVEPLQGRKH"
FT   gene            251728..253662
FT                   /gene="TPA1"
FT                   /locus_tag="YER049W"
FT   mRNA            251728..253662
FT                   /gene="TPA1"
FT                   /locus_tag="YER049W"
FT                   /product="oxidative DNA demethylase"
FT   CDS_pept        251728..253662
FT                   /codon_start=1
FT                   /gene="TPA1"
FT                   /locus_tag="YER049W"
FT                   /product="oxidative DNA demethylase"
FT                   /note="Fe(II)/2-oxoglutarate-dependent dioxygenase family
FT                   member; catalyzes the repair of methyl-base lesions in both
FT                   ss and dsDNA by oxidative demethylation; Poly(rA)-binding
FT                   protein involved in mRNA poly(A) tail length and mRNA
FT                   stability; role in translation termination efficiency;
FT                   interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p;
FT                   similar to human prolyl 4-hydroxylase OGFOD1; binds Fe(II)
FT                   and 2-oxoglutarate"
FT                   /db_xref="GOA:P40032"
FT                   /db_xref="InterPro:IPR005123"
FT                   /db_xref="InterPro:IPR006620"
FT                   /db_xref="InterPro:IPR019601"
FT                   /db_xref="InterPro:IPR039558"
FT                   /db_xref="PDB:3KT1"
FT                   /db_xref="PDB:3KT4"
FT                   /db_xref="PDB:3KT7"
FT                   /db_xref="PDB:3MGU"
FT                   /db_xref="PDB:4NHK"
FT                   /db_xref="PDB:4NHL"
FT                   /db_xref="PDB:4NHM"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40032"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006307 DNA
FT                   dealkylation involved in DNA repair [PMID:25381260]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008143 poly(A)
FT                   binding [PMID:20040577]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031543
FT                   peptidyl-proline dioxygenase activity [PMID:31320474]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035516 oxidative
FT                   DNA demethylase activity [PMID:25381260]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070989 oxidative
FT                   demethylation [PMID:25381260]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006307 DNA
FT                   dealkylation involved in DNA repair [PMID:25381260]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000288
FT                   nuclear-transcribed mRNA catabolic process,
FT                   deadenylation-dependent decay [PMID:16809762]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006307 DNA
FT                   dealkylation involved in DNA repair [PMID:25381260]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006415
FT                   translational termination [PMID:16809762|PMID:20630870]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008198 ferrous
FT                   iron binding [PMID:25381260]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0035516
FT                   oxidative DNA demethylase activity [PMID:25381260]"
FT                   /protein_id="DAA07705.1"
FT                   /translation="MKRKTAEVKGEKERNSKQISLEEDKIKGMFNPKIWDKTFQDGLKK
FT                   EIEDSQPYNWGTIHELVNDDLLRAVRKEIETEIHFTKKETDIYRVNQSGDLANLSGLDW
FT                   DDLSRLPNLFKLRQILYSKQYRDFFGYVTKAGKLSGSKTDMSINTYTKGCHLLTHDDVI
FT                   GSRRISFILYLPDPDRKWKSHYGGGLRLFPSILPNVPHSDPSAKLVPQFNQIAFFKVLP
FT                   GFSFHDVEEVKVDKHRLSIQGWYHIPQVGEEGYIPGEEEAWVRNNTSTLAQIESNVLED
FT                   FEFPKDERNILSFHEVKHFEKMLKGDAGAKTDNTPKESMTSVISDSVKLSEAEFTYLSQ
FT                   YISPEHLSSKGIEKLQKQFVENSSLQIESFLNDDKSELLKKVIKQKELEQECPYHSKDV
FT                   KAPWKTAIPPHKARYLYIDGKEYRNFQTEADILEALNNNDLPNFQFTKDAIKIISDASG
FT                   NSRENNFDAELALIDLAVFHKSTIFKKYLALLTSLCPVSEQILIRRFRPGMDFTLATKC
FT                   RFNELLKSNPDIIDAVLEGTLCLTPSAGWESGELGGYELYMMDDDEDNKQYLKEDVEDA
FT                   SVYRADDSGDSVLINDPPAWNTFNLVLRDESVLEFVKYVSWSAKSSRWDVKMKWDVKSC
FT                   DEDGQEDEA"
FT   gene            complement(253971..254387)
FT                   /gene="RSM18"
FT                   /gene_synonym="bS18m"
FT                   /locus_tag="YER050C"
FT   mRNA            complement(253971..254387)
FT                   /gene="RSM18"
FT                   /gene_synonym="bS18m"
FT                   /locus_tag="YER050C"
FT                   /product="mitochondrial 37S ribosomal protein RSM18"
FT   CDS_pept        complement(253971..254387)
FT                   /codon_start=1
FT                   /gene="RSM18"
FT                   /gene_synonym="bS18m"
FT                   /locus_tag="YER050C"
FT                   /product="mitochondrial 37S ribosomal protein RSM18"
FT                   /note="Mitochondrial ribosomal protein of the small
FT                   subunit; has similarity to E. coli S18 ribosomal protein"
FT                   /db_xref="GOA:P40033"
FT                   /db_xref="InterPro:IPR001648"
FT                   /db_xref="InterPro:IPR036870"
FT                   /db_xref="PDB:5MRC"
FT                   /db_xref="PDB:5MRE"
FT                   /db_xref="PDB:5MRF"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40033"
FT                   /experiment="EXISTENCE:curator inference:GO:0032543
FT                   mitochondrial translation [PMID:11278769]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003735 structural
FT                   constituent of ribosome [PMID:11278769]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005763
FT                   mitochondrial small ribosomal subunit [PMID:11278769]"
FT                   /protein_id="DAA07706.1"
FT                   /translation="MQPIIKGAVSSTFKRALYNFGIKEKKSVNIEMGRTQQTKKIDQSL
FT                   SKKLPKGTIYDPFDFSMGRIHLDRKYQANKNSNRNDIMKSGANPLEFYARPRILSRYVT
FT                   STGRIQHRDITGLSAKNQRRLSKAIRRCQAIGLM"
FT   gene            254656..256134
FT                   /gene="JHD1"
FT                   /gene_synonym="KDM2"
FT                   /locus_tag="YER051W"
FT   mRNA            254656..256134
FT                   /gene="JHD1"
FT                   /gene_synonym="KDM2"
FT                   /locus_tag="YER051W"
FT                   /product="[Histone H3]-lysine-36 demethylase"
FT   CDS_pept        254656..256134
FT                   /codon_start=1
FT                   /gene="JHD1"
FT                   /gene_synonym="KDM2"
FT                   /locus_tag="YER051W"
FT                   /product="[Histone H3]-lysine-36 demethylase"
FT                   /EC_number="1.14.11.27"
FT                   /note="JmjC domain family histone demethylase specific for
FT                   H3-K36; similar to proteins found in human, mouse,
FT                   drosophila, X. laevis, C. elegans, and S. pombe"
FT                   /db_xref="GOA:P40034"
FT                   /db_xref="InterPro:IPR001965"
FT                   /db_xref="InterPro:IPR003347"
FT                   /db_xref="InterPro:IPR011011"
FT                   /db_xref="InterPro:IPR013083"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40034"
FT                   /experiment="EXISTENCE:direct assay:GO:0016577 histone
FT                   demethylation [PMID:16362057]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035064 methylated
FT                   histone binding [PMID:17142463]"
FT                   /experiment="EXISTENCE:direct assay:GO:0051864 histone
FT                   demethylase activity (H3-K36 specific) [PMID:16362057]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0032968
FT                   positive regulation of transcription elongation from RNA
FT                   polymerase II promoter [PMID:17525156]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016577 histone
FT                   demethylation [PMID:17369256]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051864 histone
FT                   demethylase activity (H3-K36 specific) [PMID:17369256]"
FT                   /protein_id="DAA07707.1"
FT                   /translation="MQDPNICQHCQLKDNPGALIWVKCDSCPQWVHVKCVPLKRIHYSN
FT                   LTSSEVLSYPNSAKQIKSYRCPNHKEGEYLTAYALITQKGKRQRNKENPEDSHINKRYN
FT                   FRKKKLLDYIALNEGESKRDKMNHPHKESFMKSFEKWKNGSNIINAADFAEKFDNIDVP
FT                   YKIIDPLNSGVYVPNVGTDNGCLTVNYITEMIGEDYHVDVMDVQSQMNENWNLGSWNEY
FT                   FTNTEPDRRDRIRNVISLEVSNIEGLELERPTAVRQNDLVDKIWSFNGHLEKVNGEKAE
FT                   ENDPKPKVTKYILMSVKDAYTDFHLDFAGTSVYYNVISGQKKFLLFPPTQSNIDKYIEW
FT                   SLKEDQNSVFLGDILEDGIAMELDAGDLFMIPAGYIHAVYTPVDSLVFGGNFLTIRDLE
FT                   THLKIVEIEKLTKVPRRFTFPKFDQVMGKLCEYLALDKNKITSDVSDGDLLSRTTNCAI
FT                   QSLHAYVIKPEVKYKPLNFTSKKHLAKALADLIS"
FT   gene            complement(256375..257958)
FT                   /gene="HOM3"
FT                   /gene_synonym="BOR1"
FT                   /gene_synonym="SIL4"
FT                   /gene_synonym="THR3"
FT                   /locus_tag="YER052C"
FT   mRNA            complement(256375..257958)
FT                   /gene="HOM3"
FT                   /gene_synonym="BOR1"
FT                   /gene_synonym="SIL4"
FT                   /gene_synonym="THR3"
FT                   /locus_tag="YER052C"
FT                   /product="aspartate kinase"
FT   CDS_pept        complement(256375..257958)
FT                   /codon_start=1
FT                   /gene="HOM3"
FT                   /gene_synonym="BOR1"
FT                   /gene_synonym="SIL4"
FT                   /gene_synonym="THR3"
FT                   /locus_tag="YER052C"
FT                   /product="aspartate kinase"
FT                   /EC_number="2.7.2.4"
FT                   /note="Aspartate kinase (L-aspartate 4-P-transferase);
FT                   cytoplasmic enzyme that catalyzes the first step in the
FT                   common pathway for methionine and threonine biosynthesis;
FT                   expression regulated by Gcn4p and the general control of
FT                   amino acid synthesis"
FT                   /db_xref="GOA:P10869"
FT                   /db_xref="InterPro:IPR001048"
FT                   /db_xref="InterPro:IPR001341"
FT                   /db_xref="InterPro:IPR002912"
FT                   /db_xref="InterPro:IPR018042"
FT                   /db_xref="InterPro:IPR027795"
FT                   /db_xref="InterPro:IPR036393"
FT                   /db_xref="InterPro:IPR041747"
FT                   /db_xref="UniProtKB/Swiss-Prot:P10869"
FT                   /experiment="EXISTENCE:direct assay:GO:0004072 aspartate
FT                   kinase activity [PMID:18626862]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0009088 threonine
FT                   biosynthetic process [PMID:18626862]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004072
FT                   aspartate kinase activity [PMID:18626862]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009086
FT                   methionine biosynthetic process [PMID:4380684]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009088
FT                   threonine biosynthetic process
FT                   [PMID:18626862|PMID:4380684]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009090
FT                   homoserine biosynthetic process [PMID:4380684]"
FT                   /protein_id="DAA07708.1"
FT                   /translation="MPMDFQPTSSHSNWVVQKFGGTSVGKFPVQIVDDIVKHYSKPDGP
FT                   NNNVAVVCSARSSYTKAEGTTSRLLKCCDLASQESEFQDIIEVIRQDHIDNADRFILNP
FT                   ALQAKLVDDTNKELELVKKYLNASKVLGEVSSRTVDLVMSCGEKLSCLFMTALCNDRGC
FT                   KAKYVDLSHIVPSDFSASALDNSFYTFLVQALKEKLAPFVSAKERIVPVFTGFFGLVPT
FT                   GLLNGVGRGYTDLCAALIAVAVNADELQVWKEVDGIFTADPRKVPEARLLDSVTPEEAS
FT                   ELTYYGSEVIHPFTMEQVIRAKIPIRIKNVQNPLGNGTIIYPDNVAKKGESTPPHPPEN
FT                   LSSSFYEKRKRGATAITTKNDIFVINIHSNKKTLSHGFLAQIFTILDKYKLVVDLISTS
FT                   EVHVSMALPIPDADSLKSLRQAEEKLRILGSVDITKKLSIVSLVGKHMKQYIGIAGTMF
FT                   TTLAEEGINIEMISQGANEINISCVINESDSIKALQCIHAKLLSERTNTSNQFEHAIDE
FT                   RLEQLKRLGI"
FT   rep_origin      257958..258737
FT                   /note="ARS513; Autonomously Replicating Sequence"
FT   gene            complement(258737..259639)
FT                   /gene="PIC2"
FT                   /locus_tag="YER053C"
FT   mRNA            complement(258737..259639)
FT                   /gene="PIC2"
FT                   /locus_tag="YER053C"
FT                   /product="Cu/Pi carrier"
FT   CDS_pept        complement(258737..259639)
FT                   /codon_start=1
FT                   /gene="PIC2"
FT                   /locus_tag="YER053C"
FT                   /product="Cu/Pi carrier"
FT                   /note="Mitochondrial copper and phosphate carrier; imports
FT                   copper and inorganic phosphate into mitochondria;
FT                   functionally redundant with Mir1p but less abundant than
FT                   Mir1p under normal conditions; expression is induced at
FT                   high temperature"
FT                   /db_xref="GOA:P40035"
FT                   /db_xref="InterPro:IPR018108"
FT                   /db_xref="InterPro:IPR023395"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40035"
FT                   /experiment="EXISTENCE:direct assay:GO:0005315 inorganic
FT                   phosphate transmembrane transporter activity
FT                   [PMID:14756774]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005375 copper ion
FT                   transmembrane transporter activity [PMID:23846699]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion
FT                   [PMID:14756774|PMID:14576278|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035434 copper ion
FT                   transmembrane transport [PMID:23846699]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035435 phosphate
FT                   ion transmembrane transport [PMID:14756774]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006878 cellular
FT                   copper ion homeostasis [PMID:23846699]"
FT                   /protein_id="DAA07709.1"
FT                   /translation="MESNKQPRKIQLYTKEFYATCTLGGIIACGPTHSSITPLDLVKCR
FT                   LQVNPKLYTSNLQGFRKIIANEGWKKVYTGFGATFVGYSLQGAGKYGGYEYFKHLYSSW
FT                   LSPGVTVYLMASATAEFLADIMLCPFEAIKVKQQTTMPPFCNNVVDGWKKMYAESGGMK
FT                   AFYKGIVPLWCRQIPYTMCKFTSFEKIVQKIYSVLPKKKEEMNALQQISVSFVGGYLAG
FT                   ILCAAVSHPADVMVSKINSERKANESMSVASKRIYQKIGFTGLWNGLMVRIVMIGTLTS
FT                   FQWLIYDSFKAYVGLPTTG"
FT   gene            complement(260933..261046)
FT                   /locus_tag="YER053C-A"
FT   mRNA            complement(260933..261046)
FT                   /locus_tag="YER053C-A"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(260933..261046)
FT                   /codon_start=1
FT                   /locus_tag="YER053C-A"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; green fluorescent protein
FT                   (GFP)-fusion protein localizes to the endoplasmic
FT                   reticulum; protein abundance increases in response to DNA
FT                   replication stress"
FT                   /db_xref="EnsemblGenomes-Gn:YER053C-A"
FT                   /db_xref="EnsemblGenomes-Tr:YER053C-A"
FT                   /db_xref="GOA:Q3E7B0"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q3E7B0"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:14562095]"
FT                   /protein_id="DAA07710.1"
FT                   /translation="MQDLEIFLSIFAFIFVFYFGAHRTVMNRNKSDVPYLQ"
FT   gene            complement(262052..263698)
FT                   /gene="GIP2"
FT                   /locus_tag="YER054C"
FT   mRNA            complement(262052..263698)
FT                   /gene="GIP2"
FT                   /locus_tag="YER054C"
FT                   /product="Gip2p"
FT   CDS_pept        complement(262052..263698)
FT                   /codon_start=1
FT                   /gene="GIP2"
FT                   /locus_tag="YER054C"
FT                   /product="Gip2p"
FT                   /note="Putative regulatory subunit of protein phosphatase
FT                   Glc7p; involved in glycogen metabolism; contains a
FT                   conserved motif (GVNK motif) that is also found in Gac1p,
FT                   Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from
FT                   the whole genome duplication"
FT                   /db_xref="GOA:P40036"
FT                   /db_xref="InterPro:IPR005036"
FT                   /db_xref="InterPro:IPR016717"
FT                   /db_xref="InterPro:IPR038175"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40036"
FT                   /experiment="EXISTENCE:direct assay:GO:0019888 protein
FT                   phosphatase regulator activity [PMID:8754819]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005977 glycogen
FT                   metabolic process [PMID:11973298]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0000164
FT                   protein phosphatase type 1 complex [PMID:8754819]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0006470
FT                   protein dephosphorylation [PMID:8754819]"
FT                   /protein_id="DAA07711.1"
FT                   /translation="MYIKAEQKPQQFERKNEKLDRNKNQQLPDLETDFKGYRVNSDLYN
FT                   KERDGSTEETLNSLKFLHKPQRVTQMRANRFPEEEVQRNTDLNKRIFSAGNDENVDNES
FT                   GWSKIAAAKNHTSVESLNGSTRPPFKIELPPLSPKSTVPKSFQAEYPEAKSPGNDMNFE
FT                   YDEEILIPFAPPVYKKSGELLKSSLKRRSKSLPTTPGIRSGNGVQARDGSPMLIRSKSV
FT                   HFDQAAPVKYFAEDESPINVNKTEQHDNCLSFKHKPVNLMVDPEEETKMLSSGLETTSI
FT                   DDDLTTVAPKGFAHPAKISNPNNGKGTNNTKLRKSKRFQNLLKNRTDMPPSKSNKKFVN
FT                   GGGAHEISDRNSKNYHVVGLYSKNFPILSNKNPKSLKLNIFINLSQNKKVFLQELSLYI
FT                   HRDNNYFSNSSSFYNIPNSHNGNDCNGVAKGYNAGCTRLIAGRILVKNIFYDKRVVVRY
FT                   TWDSWRTTHEVECVYISDGDGILPGTNMDIFHFIIDDVSKVDPRGKLEFCIHYSTRNDY
FT                   EREEYWDNNNGNNYKVDVVMDGFNDPFAAAA"
FT   gene            complement(264892..265785)
FT                   /gene="HIS1"
FT                   /locus_tag="YER055C"
FT   mRNA            complement(264892..265785)
FT                   /gene="HIS1"
FT                   /locus_tag="YER055C"
FT                   /product="ATP phosphoribosyltransferase"
FT   CDS_pept        complement(264892..265785)
FT                   /codon_start=1
FT                   /gene="HIS1"
FT                   /locus_tag="YER055C"
FT                   /product="ATP phosphoribosyltransferase"
FT                   /EC_number="2.4.2.17"
FT                   /note="ATP phosphoribosyltransferase; a hexameric enzyme,
FT                   catalyzes the first step in histidine biosynthesis;
FT                   mutations cause histidine auxotrophy and sensitivity to Cu,
FT                   Co, and Ni salts; transcription is regulated by general
FT                   amino acid control"
FT                   /db_xref="GOA:P00498"
FT                   /db_xref="InterPro:IPR001348"
FT                   /db_xref="InterPro:IPR011322"
FT                   /db_xref="InterPro:IPR013115"
FT                   /db_xref="InterPro:IPR013820"
FT                   /db_xref="InterPro:IPR015867"
FT                   /db_xref="InterPro:IPR018198"
FT                   /db_xref="InterPro:IPR020621"
FT                   /db_xref="UniProtKB/Swiss-Prot:P00498"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000105
FT                   histidine biosynthetic process [PMID:14190241]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003879 ATP
FT                   phosphoribosyltransferase activity [PMID:14190241]"
FT                   /protein_id="DAA07712.1"
FT                   /translation="MDLVNHLTDRLLFAIPKKGRLYSKSVSILNGADITFHRSQRLDIA
FT                   LSTSLPVALVFLPAADIPTFVGEGKCDLGITGVDQVRESNVDVDLAIDLQFGNCKLQVQ
FT                   VPVNGEYKKPEQLIGKTIVTSFVKLAEKYFADLEGTTVEKMTTRIKFVSGSVEASCALG
FT                   IGDAIVDLVESGETMRAAGLVDIATVLSTSAYLIESKNPKSDKSLIATIKSRIEGVMTA
FT                   QRFVSCIYNAPEDKLPELLKVTPGRRAPTISKIDDEGWVAVSSMIERKTKGVVLDELKR
FT                   LGASDIMVFEISNCRV"
FT   gene            complement(266512..268113)
FT                   /gene="FCY2"
FT                   /gene_synonym="BRA7"
FT                   /locus_tag="YER056C"
FT   mRNA            complement(266512..268113)
FT                   /gene="FCY2"
FT                   /gene_synonym="BRA7"
FT                   /locus_tag="YER056C"
FT                   /product="purine-cytosine permease"
FT   CDS_pept        complement(266512..268113)
FT                   /codon_start=1
FT                   /gene="FCY2"
FT                   /gene_synonym="BRA7"
FT                   /locus_tag="YER056C"
FT                   /product="purine-cytosine permease"
FT                   /note="Purine-cytosine permease; mediates purine (adenine,
FT                   guanine, and hypoxanthine) and cytosine accumulation;
FT                   relative distribution to the vacuole increases upon DNA
FT                   replication stress"
FT                   /db_xref="GOA:P17064"
FT                   /db_xref="InterPro:IPR001248"
FT                   /db_xref="InterPro:IPR012681"
FT                   /db_xref="InterPro:IPR026030"
FT                   /db_xref="InterPro:IPR038271"
FT                   /db_xref="UniProtKB/Swiss-Prot:P17064"
FT                   /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
FT                   vacuole membrane [PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:8267570|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0015205 nucleobase
FT                   transmembrane transporter activity [PMID:9092500]"
FT                   /experiment="EXISTENCE:direct assay:GO:0015212 cytidine
FT                   transmembrane transporter activity [PMID:10501935]"
FT                   /experiment="EXISTENCE:direct assay:GO:0015856 cytosine
FT                   transport [PMID:9092500]"
FT                   /experiment="EXISTENCE:direct assay:GO:0015861 cytidine
FT                   transport [PMID:10501935]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0072530
FT                   purine-containing compound transmembrane transport
FT                   [PMID:9092500]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015212 cytidine
FT                   transmembrane transporter activity [PMID:10501935]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015861 cytidine
FT                   transport [PMID:10501935]"
FT                   /protein_id="DAA07713.1"
FT                   /translation="MLEEGNNVYEIQDLEKRSPVIGSSLENEKKVAASETFTATSEDDQ
FT                   QYIVESSEATKLSWFHKFFASLNAETKGVEPVTEDEKTDDSILNAASMWFSANMVIASY
FT                   ALGALGPMVFGLNFGQSVLVIIFFNIMGLIFVAFFSVFGAELGLRQMILSRYLVGNVTA
FT                   RIFSLINVIACVGWGIVNTSVSAQLLNMVNEGSGHVCPIWAGCLIIIGGTVLVTFFGYS
FT                   VIHAYEKWSWVPNFAVFLVIIAQLSRSGKFKGGEWVGGATTAGSVLSFGSSIFGFAAGW
FT                   TTYAADYTVYMPKSTNKYKIFFSLVAGLAFPLFFTMILGAASAMAALNDPTWKAYYDKN
FT                   AMGGVIYAILVPNSLNGFGQFCCVLLALSTIANNIPNMYTVALSAQALWAPLAKIPRVV
FT                   WTMAGNAATLGISIPATYYFDGFMENFMDSIGYYLAIYIAISCSEHFFYRRSFSAYNID
FT                   DWDNWEHLPIGIAGTAALIVGAFGVALGMCQTYWVGEIGRLIGKYGGDIGFELGASWAF
FT                   IIYNILRPLELKYFGR"
FT   gene            complement(269423..270185)
FT                   /gene="RPL34A"
FT                   /locus_tag="YER056C-A"
FT   mRNA            complement(join(269423..269751,270149..270185))
FT                   /gene="RPL34A"
FT                   /locus_tag="YER056C-A"
FT                   /product="ribosomal 60S subunit protein L34A"
FT   CDS_pept        complement(join(269423..269751,270149..270185))
FT                   /codon_start=1
FT                   /gene="RPL34A"
FT                   /locus_tag="YER056C-A"
FT                   /product="ribosomal 60S subunit protein L34A"
FT                   /note="Ribosomal 60S subunit protein L34A; homologous to
FT                   mammalian ribosomal protein L34, no bacterial homolog;
FT                   RPL34A has a paralog, RPL34B, that arose from the whole
FT                   genome duplication"
FT                   /db_xref="GOA:P87262"
FT                   /db_xref="InterPro:IPR008195"
FT                   /db_xref="InterPro:IPR018065"
FT                   /db_xref="InterPro:IPR038562"
FT                   /db_xref="PDB:3J6X"
FT                   /db_xref="PDB:3J6Y"
FT                   /db_xref="PDB:3J77"
FT                   /db_xref="PDB:3J78"
FT                   /db_xref="PDB:3JCT"
FT                   /db_xref="PDB:4U3M"
FT                   /db_xref="PDB:4U3N"
FT                   /db_xref="PDB:4U3U"
FT                   /db_xref="PDB:4U4N"
FT                   /db_xref="PDB:4U4O"
FT                   /db_xref="PDB:4U4Q"
FT                   /db_xref="PDB:4U4R"
FT                   /db_xref="PDB:4U4U"
FT                   /db_xref="PDB:4U4Y"
FT                   /db_xref="PDB:4U4Z"
FT                   /db_xref="PDB:4U50"
FT                   /db_xref="PDB:4U51"
FT                   /db_xref="PDB:4U52"
FT                   /db_xref="PDB:4U53"
FT                   /db_xref="PDB:4U55"
FT                   /db_xref="PDB:4U56"
FT                   /db_xref="PDB:4U6F"
FT                   /db_xref="PDB:4V6I"
FT                   /db_xref="PDB:4V7F"
FT                   /db_xref="PDB:4V88"
FT                   /db_xref="PDB:4V8T"
FT                   /db_xref="PDB:4V8Y"
FT                   /db_xref="PDB:4V8Z"
FT                   /db_xref="PDB:4V91"
FT                   /db_xref="PDB:5APN"
FT                   /db_xref="PDB:5APO"
FT                   /db_xref="PDB:5DAT"
FT                   /db_xref="PDB:5DC3"
FT                   /db_xref="PDB:5DGE"
FT                   /db_xref="PDB:5DGF"
FT                   /db_xref="PDB:5DGV"
FT                   /db_xref="PDB:5FCI"
FT                   /db_xref="PDB:5FCJ"
FT                   /db_xref="PDB:5FL8"
FT                   /db_xref="PDB:5GAK"
FT                   /db_xref="PDB:5H4P"
FT                   /db_xref="PDB:5I4L"
FT                   /db_xref="PDB:5JCS"
FT                   /db_xref="PDB:5JUO"
FT                   /db_xref="PDB:5JUP"
FT                   /db_xref="PDB:5JUS"
FT                   /db_xref="PDB:5JUT"
FT                   /db_xref="PDB:5JUU"
FT                   /db_xref="PDB:5LYB"
FT                   /db_xref="PDB:5M1J"
FT                   /db_xref="PDB:5MC6"
FT                   /db_xref="PDB:5MEI"
FT                   /db_xref="PDB:5NDG"
FT                   /db_xref="PDB:5NDV"
FT                   /db_xref="PDB:5NDW"
FT                   /db_xref="PDB:5OBM"
FT                   /db_xref="PDB:5ON6"
FT                   /db_xref="PDB:5T62"
FT                   /db_xref="PDB:5T6R"
FT                   /db_xref="PDB:5TBW"
FT                   /db_xref="PDB:5TGA"
FT                   /db_xref="PDB:5TGM"
FT                   /db_xref="PDB:6CB1"
FT                   /db_xref="PDB:6ELZ"
FT                   /db_xref="PDB:6EM5"
FT                   /db_xref="PDB:6FT6"
FT                   /db_xref="PDB:6GQ1"
FT                   /db_xref="PDB:6GQB"
FT                   /db_xref="PDB:6GQV"
FT                   /db_xref="PDB:6HD7"
FT                   /db_xref="PDB:6HHQ"
FT                   /db_xref="PDB:6I7O"
FT                   /db_xref="PDB:6N8J"
FT                   /db_xref="PDB:6N8K"
FT                   /db_xref="PDB:6N8L"
FT                   /db_xref="PDB:6N8M"
FT                   /db_xref="PDB:6N8N"
FT                   /db_xref="PDB:6N8O"
FT                   /db_xref="PDB:6Q8Y"
FT                   /db_xref="PDB:6QIK"
FT                   /db_xref="PDB:6QT0"
FT                   /db_xref="PDB:6QTZ"
FT                   /db_xref="PDB:6R84"
FT                   /db_xref="PDB:6R87"
FT                   /db_xref="PDB:6RI5"
FT                   /db_xref="PDB:6RZZ"
FT                   /db_xref="PDB:6S05"
FT                   /db_xref="UniProtKB/Swiss-Prot:P87262"
FT                   /experiment="EXISTENCE:curator inference:GO:0002181
FT                   cytoplasmic translation [PMID:23874617]"
FT                   /experiment="EXISTENCE:curator inference:GO:0003735
FT                   structural constituent of ribosome [PMID:23874617]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030687 preribosome,
FT                   large subunit precursor [PMID:23874617]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042254 ribosome
FT                   biogenesis [PMID:23874617]"
FT                   /protein_id="DAA07714.1"
FT                   /translation="MAQRVTFRRRNPYNTRSNKIKVVKTPGGILRAQHVKKLATRPKCG
FT                   DCGSALQGISTLRPRQYATVSKTHKTVSRAYGGSRCANCVKERIIRAFLIEEQKIVKKV
FT                   VKEQTEAAKKSEKKAKK"
FT   gene            complement(270737..271126)
FT                   /gene="HMF1"
FT                   /gene_synonym="HIG1"
FT                   /locus_tag="YER057C"
FT   mRNA            complement(270737..271126)
FT                   /gene="HMF1"
FT                   /gene_synonym="HIG1"
FT                   /locus_tag="YER057C"
FT                   /product="putative isoleucine biosynthesis protein HMF1"
FT   CDS_pept        complement(270737..271126)
FT                   /codon_start=1
FT                   /gene="HMF1"
FT                   /gene_synonym="HIG1"
FT                   /locus_tag="YER057C"
FT                   /product="putative isoleucine biosynthesis protein HMF1"
FT                   /note="Member of the p14.5 protein family; functionally
FT                   complements Mmf1p function when targeted to mitochondria;
FT                   heat shock inducible; high-dosage growth inhibitor; forms a
FT                   homotrimer in vitro; HMF1 has a paralog, MMF1, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P40037"
FT                   /db_xref="InterPro:IPR006056"
FT                   /db_xref="InterPro:IPR006175"
FT                   /db_xref="InterPro:IPR019897"
FT                   /db_xref="InterPro:IPR035959"
FT                   /db_xref="PDB:1JD1"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40037"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:11442631]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:11442631]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005758
FT                   mitochondrial intermembrane space [PMID:22984289]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:11003673]"
FT                   /protein_id="DAA07715.1"
FT                   /translation="MVTTLTPVICESAPAAAASYSHAMKVNNLIFLSGQIPVTPDNKLV
FT                   EGSIADKAEQVIQNIKNVLEASNSSLDRVVKVNIFLADINHFAEFNSVYAKYFNTHKPA
FT                   RSCVAVAALPLGVDMEMEAIAAERD"
FT   gene            271768..272091
FT                   /gene="PET117"
FT                   /locus_tag="YER058W"
FT   mRNA            271768..272091
FT                   /gene="PET117"
FT                   /locus_tag="YER058W"
FT                   /product="Pet117p"
FT   CDS_pept        271768..272091
FT                   /codon_start=1
FT                   /gene="PET117"
FT                   /locus_tag="YER058W"
FT                   /product="Pet117p"
FT                   /note="Assembly factor that couples heme a synthesis to
FT                   complex IV assembly; regulates the oligomerization state of
FT                   the Cox15p heme a synthase, and couples this to the
FT                   assembly of the cytochrome C oxidase complex (complex IV)"
FT                   /db_xref="GOA:Q02771"
FT                   /db_xref="InterPro:IPR031568"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q02771"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005759
FT                   mitochondrial matrix [PMID:27998984]"
FT                   /experiment="EXISTENCE:direct assay:GO:0099616 extrinsic
FT                   component of matrix side of mitochondrial inner membrane
FT                   [PMID:27998984]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0033617
FT                   mitochondrial respiratory chain complex IV assembly
FT                   [PMID:8381337|PMID:27998984]"
FT                   /protein_id="DAA07716.1"
FT                   /translation="MSRASKITFAASCLITAATVVGVHYVQEMERETLHQGPIKDAKRV
FT                   EEKRLRKTNGVASLDPTKERKRYFNMSEHEEQKELRKKYETMQPLSGEVVTKDGEVVKE
FT                   SKK"
FT   gene            272624..273886
FT                   /gene="PCL6"
FT                   /locus_tag="YER059W"
FT   mRNA            272624..273886
FT                   /gene="PCL6"
FT                   /locus_tag="YER059W"
FT                   /product="Pcl6p"
FT   CDS_pept        272624..273886
FT                   /codon_start=1
FT                   /gene="PCL6"
FT                   /locus_tag="YER059W"
FT                   /product="Pcl6p"
FT                   /note="Pho85p cyclin of the Pho80p subfamily; forms the
FT                   major Glc8p kinase together with Pcl7p and Pho85p; involved
FT                   in the control of glycogen storage by Pho85p; stabilized by
FT                   Elongin C binding; PCL6 has a paralog, PCL7, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P40038"
FT                   /db_xref="InterPro:IPR013922"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40038"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0005979
FT                   regulation of glycogen biosynthetic process
FT                   [PMID:11602261]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0005981
FT                   regulation of glycogen catabolic process [PMID:11602261]"
FT                   /protein_id="DAA07717.1"
FT                   /translation="MSIKGDSPSSTNASSSPKSTYSIQSDDKANLGSGNVDIRTDNSQQ
FT                   DSNNRRDIVVVTRVASEETLESQSSTSSMGIRPESSFNYEDASNQARVEMNNRVHGSNM
FT                   NTINKYYPVRFPKNNERQLSDTNNLNEKVQGTHTVQSSTQEDKILDGDTSNSQVTPSLN
FT                   IAEFPTDKLLKMLTALLTKIIKSNDRTAATNPSLTQEIENGRCLALSDNEKKYLSPVLG
FT                   FRGKHVPQIGLDQYFQRIQKYCPTTNDVFLSLLVYFDRISKRCNSVTTTPKTNTAKHES
FT                   PSNESSLDKANRGADKMSACNSNENNENDDSDDENTGVQRDSRAHPQMFVMDSHNIHRL
FT                   IIAGITVSTKFLSDFFYSNSRYSRVGGISLQELNHLELQFLVLCDFELLISVNELQRYA
FT                   DLLYRFWNNAKAQSQALVTGM"
FT   gene            274567..276153
FT                   /gene="FCY21"
FT                   /locus_tag="YER060W"
FT   mRNA            274567..276153
FT                   /gene="FCY21"
FT                   /locus_tag="YER060W"
FT                   /product="purine-cytosine permease"
FT   CDS_pept        274567..276153
FT                   /codon_start=1
FT                   /gene="FCY21"
FT                   /locus_tag="YER060W"
FT                   /product="purine-cytosine permease"
FT                   /note="Putative purine-cytosine permease; very similar to
FT                   Fcy2p but cannot substitute for its function"
FT                   /db_xref="GOA:P40039"
FT                   /db_xref="InterPro:IPR001248"
FT                   /db_xref="InterPro:IPR012681"
FT                   /db_xref="InterPro:IPR026030"
FT                   /db_xref="InterPro:IPR038271"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40039"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015205
FT                   nucleobase transmembrane transporter activity
FT                   [PMID:16845689]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015856 cytosine
FT                   transport [PMID:16845689]"
FT                   /protein_id="DAA07718.1"
FT                   /translation="MPQTHEMSLNGTQYLKYELKDLESRAHDAKTPSTNEFYDDVESHG
FT                   TEELVEAKLSFLNRIAAGLSAETKGIEPITEDEKTDDSILNAASMWFSANMVLPAYAIG
FT                   ALGPMVFDLNFGQSVFVIIFFNLLGLVSVAFFSVFGAELGLRQMILSRYLVGNIAARIF
FT                   SFINFIACIGWGIVNTVASSQVLNMVNPGHQCPLWAGCIVIIGATVIVTFFGYGVIHAY
FT                   EKWAWVPNFAVFLVIIARLARSKKFVLGEWTSGPTTAGNVLSFGSTVYGFAAGWTTYAA
FT                   DYTVYMPRKTNKYKIFFSLVVGLATPLYFTMILGAAVAMAAIGDPAWKTYYDENSIGGL
FT                   TFAVLVPNSVHGFGQFCCVLLSLSTIANNVPNMYTIALSVQATWEPLAKVPRVIWTLLG
FT                   NAAALGIAIPACYYFSTFMNYFMDSIGYYLAIYIAIACSEHFIYRRSFSAYNVDDWDSW
FT                   ERLPIGIAGTAALIVGAFGVALGMCQTYWVGEISRLIGDYGGDIGFELGLSWAFIVYNI
FT                   ARPFELKYFGR"
FT   rep_origin      276130..276528
FT                   /note="ARS513.5; Very weak autonomously replicating
FT                   sequence"
FT   gene            276572..278164
FT                   /gene="FCY22"
FT                   /locus_tag="YER060W-A"
FT   mRNA            276572..278164
FT                   /gene="FCY22"
FT                   /locus_tag="YER060W-A"
FT                   /product="purine-cytosine permease"
FT   CDS_pept        276572..278164
FT                   /codon_start=1
FT                   /gene="FCY22"
FT                   /locus_tag="YER060W-A"
FT                   /product="purine-cytosine permease"
FT                   /note="Putative purine-cytosine permease; very similar to
FT                   Fcy2p but cannot substitute for its function"
FT                   /db_xref="GOA:Q12119"
FT                   /db_xref="InterPro:IPR001248"
FT                   /db_xref="InterPro:IPR012681"
FT                   /db_xref="InterPro:IPR026030"
FT                   /db_xref="InterPro:IPR038271"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q12119"
FT                   /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
FT                   vacuole [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:26928762]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015205
FT                   nucleobase transmembrane transporter activity
FT                   [PMID:16845689]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015856 cytosine
FT                   transport [PMID:16845689]"
FT                   /protein_id="DAA07719.1"
FT                   /translation="MPEKLAMSMVDIKDAGSELRDLESGALDTKSSAADVYYEGVELHR
FT                   TNEFIDNKPSFFNRIAAALNAETKGIEPVTEDEKNDDSILNAATIWFSANMVIVAYSVG
FT                   ALGPLVFGLNFGQSVLVIIFFNILGLIPVALFSLFGVELGLRQMILSRYLAGNITARFF
FT                   SLVNVIACVGWCVLNISVSAQLLNMVNEGSGHNCPIWAGCLIIAGGTVLVTFFGYSVVH
FT                   AYEKWSWVPNFAAFLVIIAQLSRSGKFKGGEWVGGATTAGGVLSFGSSVFGSAAGWATY
FT                   AADYTVYMPKTTSKYKIFFSVVAGLAFPLFFTMILGAACGMAALNDPTWKSYYDKNAMG
FT                   GVIYAILVPNSLNGFGQFCCVLLALSTVANNVPGMYTVALSAQALWAPLAKIPRVVWTM
FT                   AGNAATLGISIPATYYFDGFMENFMDSIGYYLAIYIAIACSEHFIYRRSFSAYNIDDWD
FT                   NWEHLPIGIAGTAALIAGAFGVALGMCQTYWVGEISRLIGEYGGDIGFELGGSWAFIIY
FT                   NIVRPLELKYFGR"
FT   rep_origin      278076..278357
FT                   /note="ARS513.7; Weak autonomously replicating sequence"
FT   gene            complement(278298..279626)
FT                   /gene="CEM1"
FT                   /locus_tag="YER061C"
FT   mRNA            complement(278298..279626)
FT                   /gene="CEM1"
FT                   /locus_tag="YER061C"
FT                   /product="fatty acid synthase CEM1"
FT   CDS_pept        complement(278298..279626)
FT                   /codon_start=1
FT                   /gene="CEM1"
FT                   /locus_tag="YER061C"
FT                   /product="fatty acid synthase CEM1"
FT                   /EC_number="2.3.1.41"
FT                   /note="Mitochondrial beta-keto-acyl synthase; possible role
FT                   in fatty acid synthesis; required for mitochondrial
FT                   respiration; human homolog OXSM can complement yeast cem1
FT                   null mutant"
FT                   /db_xref="GOA:P39525"
FT                   /db_xref="InterPro:IPR000794"
FT                   /db_xref="InterPro:IPR014030"
FT                   /db_xref="InterPro:IPR014031"
FT                   /db_xref="InterPro:IPR016039"
FT                   /db_xref="InterPro:IPR018201"
FT                   /db_xref="InterPro:IPR020841"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39525"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]"
FT                   /protein_id="DAA07720.2"
FT                   /translation="MSRRVVITGLGCVTPLGRSLSESWGNLLSSKNGLTPITSLPNYNE
FT                   DYKLREKSIPSTITVGKIPENFQNENSAINKLLFTSQDERRTSSFIKLALRTTYEALHN
FT                   AGLLNPNDITINTSLCNLDHFGCLIGSGIGSIQDIYQTSLQFHNDNKRINPYFVPKILT
FT                   NMAAGNVSIKFNLRGLSHSVSTACATGNNSIGDAFNFIRLGMQDICVAGASETSLHPLS
FT                   LAGFIRAKSITTNGISRPFDTQRSGFVLGEGCGMIVMESLEHAQKRNANIISELVGYGL
FT                   SSDACHITSPPADGNGAKRAIEMALKMARLEPTDVDYVNAHATSTLLGDKAECLAVASA
FT                   LLPGRSKSKPLYISSNKGAIGHLLGAAGAVESIFTICSLKDDKMPHTLNLDNVLTLENN
FT                   EADKLHFIRDKPIVGANPKYALCNSFGFGGVNTSLLFKKWEGS"
FT   gene            complement(279930..280682)
FT                   /gene="GPP2"
FT                   /gene_synonym="HOR2"
FT                   /locus_tag="YER062C"
FT   mRNA            complement(279930..280682)
FT                   /gene="GPP2"
FT                   /gene_synonym="HOR2"
FT                   /locus_tag="YER062C"
FT                   /product="glycerol-1-phosphatase HOR2"
FT   CDS_pept        complement(279930..280682)
FT                   /codon_start=1
FT                   /gene="GPP2"
FT                   /gene_synonym="HOR2"
FT                   /locus_tag="YER062C"
FT                   /product="glycerol-1-phosphatase HOR2"
FT                   /EC_number="3.1.3.21"
FT                   /note="DL-glycerol-3-phosphate phosphatase involved in
FT                   glycerol biosynthesis; also known as
FT                   glycerol-1-phosphatase; induced in response to hyperosmotic
FT                   or oxidative stress, and during diauxic shift; GPP2 has a
FT                   paralog, GPP1, that arose from the whole genome
FT                   duplication"
FT                   /db_xref="GOA:P40106"
FT                   /db_xref="InterPro:IPR006439"
FT                   /db_xref="InterPro:IPR023198"
FT                   /db_xref="InterPro:IPR023214"
FT                   /db_xref="InterPro:IPR036412"
FT                   /db_xref="InterPro:IPR041492"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40106"
FT                   /experiment="EXISTENCE:direct assay:GO:0000121
FT                   glycerol-1-phosphatase activity [PMID:8662716]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006970 response to
FT                   osmotic stress [PMID:8662716]"
FT                   /experiment="EXISTENCE:direct assay:GO:0044262 cellular
FT                   carbohydrate metabolic process [PMID:8662716]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006114 glycerol
FT                   biosynthetic process [PMID:11058591]"
FT                   /protein_id="DAA07721.1"
FT                   /translation="MGLTTKPLSLKVNAALFDVDGTIIISQPAIAAFWRDFGKDKPYFD
FT                   AEHVIQVSHGWRTFDAIAKFAPDFANEEYVNKLEAEIPVKYGEKSIEVPGAVKLCNALN
FT                   ALPKEKWAVATSGTRDMAQKWFEHLGIRRPKYFITANDVKQGKPHPEPYLKGRNGLGYP
FT                   INEQDPSKSKVVVFEDAPAGIAAGKAAGCKIIGIATTFDLDFLKEKGCDIIVKNHESIR
FT                   VGGYNAETDEVEFIFDDYLYAKDDLLKW"
FT   gene            281710..282366
FT                   /gene="THO1"
FT                   /locus_tag="YER063W"
FT   mRNA            281710..282366
FT                   /gene="THO1"
FT                   /locus_tag="YER063W"
FT                   /product="Tho1p"
FT   CDS_pept        281710..282366
FT                   /codon_start=1
FT                   /gene="THO1"
FT                   /locus_tag="YER063W"
FT                   /product="Tho1p"
FT                   /note="Conserved nuclear RNA-binding protein; specifically
FT                   binds to transcribed chromatin in a THO- and RNA-dependent
FT                   manner, genetically interacts with shuttling hnRNP NAB2;
FT                   overproduction suppresses transcriptional defect caused by
FT                   hpr1 mutation"
FT                   /db_xref="GOA:P40040"
FT                   /db_xref="InterPro:IPR003034"
FT                   /db_xref="InterPro:IPR036361"
FT                   /db_xref="InterPro:IPR040746"
FT                   /db_xref="PDB:1H1J"
FT                   /db_xref="PDB:2WQG"
FT                   /db_xref="PDB:4UZW"
FT                   /db_xref="PDB:4UZX"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40040"
FT                   /experiment="EXISTENCE:direct assay:GO:0003682 chromatin
FT                   binding [PMID:16738307]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003690
FT                   double-stranded DNA binding [PMID:16738307]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
FT                   [PMID:16738307]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006368
FT                   transcription elongation from RNA polymerase II promoter
FT                   [PMID:9707445]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0016973
FT                   poly(A)+ mRNA export from nucleus [PMID:16738307]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0022618
FT                   ribonucleoprotein complex assembly [PMID:16738307]"
FT                   /protein_id="DAA07722.1"
FT                   /translation="MADYSSLTVVQLKDLLTKRNLSVGGLKNELVQRLIKDDEESKGES
FT                   EVSPQEQNQEQGSEPAAIEEPASQNITEKKEVSSEPKETNEPKEENKDVQKPSDGPSAT
FT                   ASENEQAAASTAAPALSPEEIKAKALDLLNKKLHRANKFGQDQADIDSLQRQINRVEKF
FT                   GVDLNSKLAEELGLVSRKNEPESGNNGKFKNRNKNANNRSRVSKNRRGNRSGYRR"
FT   gene            complement(282705..284222)
FT                   /gene="VHR2"
FT                   /locus_tag="YER064C"
FT   mRNA            complement(282705..284222)
FT                   /gene="VHR2"
FT                   /locus_tag="YER064C"
FT                   /product="Vhr2p"
FT   CDS_pept        complement(282705..284222)
FT                   /codon_start=1
FT                   /gene="VHR2"
FT                   /locus_tag="YER064C"
FT                   /product="Vhr2p"
FT                   /note="Non-essential nuclear protein; null mutation has
FT                   global effects on transcription; VHR2 has a paralog, VHR1,
FT                   that arose from the whole genome duplication; relative
FT                   distribution to the nucleus increases upon DNA replication
FT                   stress"
FT                   /db_xref="GOA:P40041"
FT                   /db_xref="InterPro:IPR007147"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40041"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:22842922]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006355
FT                   regulation of transcription, DNA-templated [PMID:11342098]"
FT                   /protein_id="DAA07723.1"
FT                   /translation="MIDDTENSKIHLEGSHKTGKYTGYGTTHKIRAQLNFNDEKKWKKF
FT                   SSRRLELIDSFGLSQHKASEQDDNIRQIATILRSEFEYPDTFSAEFEKLVTAAVQSVRR
FT                   NRKRSKKKLLDSKKKIARGKVQKIPLSPPSSSNMGSCSASNASSSDEEASVKEEPAEHA
FT                   LPSLNTITSQKLLPYPNGRTLPPVPTQVRSLLKKNASLLRDPSAPYAHGGDEKLQKFDI
FT                   EDQPLESEQEYDFIAKSIIVEIVNNAIPLPEQIQRDKFIRPNLTKKKGCQSKVVISNNL
FT                   RKLILSKIHNSRTCLEMSKDERNLDSFANLETLGKNSLMASISLVVENSFSHLPSSTKQ
FT                   YLTERLSSIEFLTILSQRLFMPATRQLFADLSQEKIQVRVLNLILGSLVKDYGFDASLA
FT                   PINEIIYHMTLHQYPLVCSNKQSNPMRPHSTSEVLSAHSSTKDASTPGKEEPRVTRSST
FT                   SADSTIITLPSIEVPNTYDDDRLKMLSAISLQIENSTFSKPFSTISK"
FT   gene            complement(285241..286914)
FT                   /gene="ICL1"
FT                   /locus_tag="YER065C"
FT   mRNA            complement(285241..286914)
FT                   /gene="ICL1"
FT                   /locus_tag="YER065C"
FT                   /product="isocitrate lyase 1"
FT   CDS_pept        complement(285241..286914)
FT                   /codon_start=1
FT                   /gene="ICL1"
FT                   /locus_tag="YER065C"
FT                   /product="isocitrate lyase 1"
FT                   /EC_number="4.1.3.1"
FT                   /EC_number="4.1.3.30"
FT                   /note="Isocitrate lyase; catalyzes the formation of
FT                   succinate and glyoxylate from isocitrate, a key reaction of
FT                   the glyoxylate cycle; expression of ICL1 is induced by
FT                   growth on ethanol and repressed by growth on glucose"
FT                   /db_xref="GOA:P28240"
FT                   /db_xref="InterPro:IPR006254"
FT                   /db_xref="InterPro:IPR015813"
FT                   /db_xref="InterPro:IPR018523"
FT                   /db_xref="InterPro:IPR039556"
FT                   /db_xref="InterPro:IPR040442"
FT                   /db_xref="UniProtKB/Swiss-Prot:P28240"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:8870676|PMID:9370278]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004451
FT                   isocitrate lyase activity [PMID:1551398]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006097
FT                   glyoxylate cycle [PMID:8878673]"
FT                   /protein_id="DAA07724.1"
FT                   /translation="MPIPVGNTKNDFAALQAKLDADAAEIEKWWSDSRWSKTKRNYSAR
FT                   DIAVRRGTFPPIEYPSSVMARKLFKVLEKHHNEGTVSKTFGALDPVQISQMAKYLDTIY
FT                   ISGWQCSSTASTSNEPGPDLADYPMDTVPNKVEHLFKAQLFHDRKQLEARSKAKSQEEL
FT                   DEMGAPIDYLTPIVADADAGHGGLTAVFKLTKMFIERGAAGIHMEDQTSTNKKCGHMAG
FT                   RCVIPVQEHVNRLVTIRMCADIMHSDLIVVARTDSEAATLISSTIDTRDHYFIVGATNP
FT                   NIEPFAEVLNDAIMSGASGQELADIEQKWCRDAGLKLFHEAVIDEIERSALSNKQELIK
FT                   KFTSKVGPLTETSHREAKKLAKEILGHEIFFDWELPRVREGLYRYRGGTQCSIMRARAF
FT                   APYADLVWMESNYPDFQQAKEFAEGVKEKFPDQWLAYNLSPSFNWPKAMSVDEQHTFIQ
FT                   RLGDLGYIWQFITLAGLHTNALAVHNFSRDFAKDGMKAYAQNVQQREMDDGVDVLKHQK
FT                   WSGAEYIDGLLKLAQGGVSATAAMGTGVTEDQFKENGVKK"
FT   rep_origin      287552..287629
FT                   /note="ARS514; Autonomously Replicating Sequence"
FT   repeat_region   complement(287745..288062)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            complement(288443..288524)
FT                   /gene="SUP19"
FT                   /locus_tag="tS(UGA)E"
FT   tRNA            complement(288443..288524)
FT                   /gene="SUP19"
FT                   /locus_tag="tS(UGA)E"
FT                   /product="tRNA-Ser"
FT                   /note="tS(UGA)E; Serine tRNA (tRNA-Ser), predicted by
FT                   tRNAscan-SE analysis; can mutate to suppress ochre nonsense
FT                   mutations"
FT                   /experiment="EXISTENCE:curator inference:GO:0002181
FT                   cytoplasmic translation [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   gene            290242..290799
FT                   /gene="RRT13"
FT                   /locus_tag="YER066W"
FT   mRNA            290242..290799
FT                   /gene="RRT13"
FT                   /locus_tag="YER066W"
FT                   /product="Rrt13p"
FT   CDS_pept        290242..290799
FT                   /codon_start=1
FT                   /gene="RRT13"
FT                   /locus_tag="YER066W"
FT                   /product="Rrt13p"
FT                   /note="hypothetical protein; non-essential gene identified
FT                   in a screen for mutants with decreased levels of rDNA
FT                   transcription"
FT                   /db_xref="GOA:P40042"
FT                   /db_xref="InterPro:IPR001680"
FT                   /db_xref="InterPro:IPR015943"
FT                   /db_xref="InterPro:IPR017986"
FT                   /db_xref="InterPro:IPR019775"
FT                   /db_xref="InterPro:IPR020472"
FT                   /db_xref="InterPro:IPR036322"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40042"
FT                   /protein_id="DAA07725.1"
FT                   /translation="MKCLYILSGHTDRIYSTIYDHERKRCISASMDTTIRIWDLENIRN
FT                   NGECSYATNSASPCAKILGAMYTLRGHRALVGLLGLSDKFLVSASVDGSIRCWDANTYF
FT                   LKHFFDHTQLNTITALHVSDEVLVSGSEGLLNIYDLNSGLLVRSDTLSGADNVWNVSFK
FT                   DNTLVAAVERDKRNLLEILDFS"
FT   gene            292066..292551
FT                   /gene="RGI1"
FT                   /locus_tag="YER067W"
FT   mRNA            292066..292551
FT                   /gene="RGI1"
FT                   /locus_tag="YER067W"
FT                   /product="Rgi1p"
FT   CDS_pept        292066..292551
FT                   /codon_start=1
FT                   /gene="RGI1"
FT                   /locus_tag="YER067W"
FT                   /product="Rgi1p"
FT                   /note="hypothetical protein; involved in energy metabolism
FT                   under respiratory conditions; protein abundance is
FT                   increased upon intracellular iron depletion or in response
FT                   to DNA replication stress; RGI1 has a paralog, RGI2, that
FT                   arose from the whole genome duplication"
FT                   /db_xref="GOA:P40043"
FT                   /db_xref="InterPro:IPR022554"
FT                   /db_xref="InterPro:IPR038235"
FT                   /db_xref="PDB:3BCY"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40043"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:20567505]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006112 energy
FT                   reserve metabolic process [PMID:20567505]"
FT                   /protein_id="DAA07726.1"
FT                   /translation="MTKKDKKEVKVQTVTTEDGETVKVFEDLQGFETFIANETEDDDFD
FT                   HLHCKLNYYPPFVLHESHEDPEKISDAANSHSKKFVRHLHQHIEKHLLKDIKQAVRKPE
FT                   LKFHEKSKEETFDKITWHYGEETEYHGRPFKIDVQVVCTHEDAMVFVDYKTHPVGAN"
FT   gene            293050..294813
FT                   /gene="MOT2"
FT                   /gene_synonym="NOT4"
FT                   /gene_synonym="SIG1"
FT                   /locus_tag="YER068W"
FT   mRNA            293050..294813
FT                   /gene="MOT2"
FT                   /gene_synonym="NOT4"
FT                   /gene_synonym="SIG1"
FT                   /locus_tag="YER068W"
FT                   /product="CCR4-NOT core ubiquitin-protein ligase subunit
FT                   MOT2"
FT   CDS_pept        293050..294813
FT                   /codon_start=1
FT                   /gene="MOT2"
FT                   /gene_synonym="NOT4"
FT                   /gene_synonym="SIG1"
FT                   /locus_tag="YER068W"
FT                   /product="CCR4-NOT core ubiquitin-protein ligase subunit
FT                   MOT2"
FT                   /note="Ubiquitin-protein ligase subunit of the CCR4-NOT
FT                   complex; with Ubc4p, ubiquitinates nascent
FT                   polypeptide-associated complex subunits and histone
FT                   demethyase Jhd2p; CCR4-NOT has roles in transcription
FT                   regulation, mRNA degradation, and post-transcriptional
FT                   modifications; regulates levels of DNA Polymerase-{alpha}
FT                   to promote efficient and accurate DNA replication"
FT                   /db_xref="GOA:P34909"
FT                   /db_xref="InterPro:IPR000504"
FT                   /db_xref="InterPro:IPR000571"
FT                   /db_xref="InterPro:IPR001841"
FT                   /db_xref="InterPro:IPR003954"
FT                   /db_xref="InterPro:IPR012677"
FT                   /db_xref="InterPro:IPR013083"
FT                   /db_xref="InterPro:IPR034261"
FT                   /db_xref="InterPro:IPR035979"
FT                   /db_xref="InterPro:IPR039515"
FT                   /db_xref="InterPro:IPR039780"
FT                   /db_xref="PDB:5AIE"
FT                   /db_xref="PDB:5AJD"
FT                   /db_xref="UniProtKB/Swiss-Prot:P34909"
FT                   /experiment="EXISTENCE:direct assay:GO:0000209 protein
FT                   polyubiquitination [PMID:19346402]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004842
FT                   ubiquitin-protein transferase activity
FT                   [PMID:16926149|PMID:19346402]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:11889048]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016567 protein
FT                   ubiquitination [PMID:16926149]"
FT                   /experiment="EXISTENCE:direct assay:GO:0032968 positive
FT                   regulation of transcription elongation from RNA polymerase
FT                   II promoter [PMID:21406554]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0010498
FT                   proteasomal protein catabolic process [PMID:24261871]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein
FT                   polyubiquitination [PMID:19346402]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031087
FT                   deadenylation-independent decapping of nuclear-transcribed
FT                   mRNA [PMID:15706350]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive
FT                   regulation of transcription elongation from RNA polymerase
FT                   II promoter [PMID:11404327]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0030015
FT                   CCR4-NOT core complex [PMID:10490603]"
FT                   /protein_id="DAA07727.1"
FT                   /translation="MMNPHVQENLQAIHNALSNFDTSFLSEDEEDYCPLCIEPMDITDK
FT                   NFFPCPCGYQICQFCYNNIRQNPELNGRCPACRRKYDDENVRYVTLSPEELKMERAKLA
FT                   RKEKERKHREKERKENEYTNRKHLSGTRVIQKNLVYVVGINPPVPYEEVAPTLKSEKYF
FT                   GQYGKINKIVVNRKTPHSNNTTSEHYHHHSPGYGVYITFGSKDDAARCIAQVDGTYMDG
FT                   RLIKAAYGTTKYCSSYLRGLPCPNPNCMFLHEPGEEADSFNKRELHNKQQAQQQSGGTA
FT                   FTRSGIHNNISTSTAGSNTNLLSENFTGTPSPAAMRAQLHHDSHTNAGTPVLTPAPVPA
FT                   GSNPWGVTQSATPVTSINLSKNSSSINLPTLNDSLGHHTTPTTENTITSTTTTTNTNAT
FT                   SHSHGSKKKQSLAAEEYKDPYDALGNAVDFLDARLHSLSNYQKRPISIKSNIIDEETYK
FT                   KYPSLFSWDKIEASKKSDNTLANKLVEILAIKPIDYTASVVQFLQSVNVGVNDNITITD
FT                   NTKTPTQPIRLQTVSQQIQPPLNVSTPPPGIFGPQHKVPIQQQQMGDTSSRNSSDLLNQ
FT                   LINGRKIIAGN"
FT   gene            295410..298001
FT                   /gene="ARG5,6"
FT                   /locus_tag="YER069W"
FT   mRNA            295410..298001
FT                   /gene="ARG5,6"
FT                   /locus_tag="YER069W"
FT                   /product="bifunctional acetylglutamate
FT                   kinase/N-acetyl-gamma-glutamyl-phosphate reductase"
FT   CDS_pept        295410..298001
FT                   /codon_start=1
FT                   /gene="ARG5,6"
FT                   /locus_tag="YER069W"
FT                   /product="bifunctional acetylglutamate
FT                   kinase/N-acetyl-gamma-glutamyl-phosphate reductase"
FT                   /EC_number="2.7.2.8"
FT                   /EC_number="1.2.1.38"
FT                   /note="Acetylglutamate kinase and
FT                   N-acetyl-gamma-glutamyl-phosphate reductase;
FT                   N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and
FT                   N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the
FT                   3rd step in arginine biosynthesis; synthesized as a
FT                   precursor which is processed in the mitochondrion to yield
FT                   mature NAGK and NAGSA; enzymes form a metabolon complex
FT                   with Arg2p; NAGK C-terminal domain stabilizes the enzymes,
FT                   slows catalysis and is involved in feed-back inhibition by
FT                   arginine"
FT                   /db_xref="GOA:Q01217"
FT                   /db_xref="InterPro:IPR000534"
FT                   /db_xref="InterPro:IPR000706"
FT                   /db_xref="InterPro:IPR001048"
FT                   /db_xref="InterPro:IPR004662"
FT                   /db_xref="InterPro:IPR006855"
FT                   /db_xref="InterPro:IPR011241"
FT                   /db_xref="InterPro:IPR012280"
FT                   /db_xref="InterPro:IPR023013"
FT                   /db_xref="InterPro:IPR036291"
FT                   /db_xref="InterPro:IPR036393"
FT                   /db_xref="InterPro:IPR041734"
FT                   /db_xref="PDB:3ZZF"
FT                   /db_xref="PDB:3ZZG"
FT                   /db_xref="PDB:3ZZH"
FT                   /db_xref="PDB:3ZZI"
FT                   /db_xref="PDB:4AB7"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q01217"
FT                   /experiment="EXISTENCE:direct assay:GO:0003942
FT                   N-acetyl-gamma-glutamyl-phosphate reductase activity
FT                   [PMID:1851947]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003991
FT                   acetylglutamate kinase activity [PMID:1851947]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005759
FT                   mitochondrial matrix [PMID:1851947]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006355
FT                   regulation of transcription, DNA-templated [PMID:15486299]"
FT                   /protein_id="DAA07728.1"
FT                   /translation="MPSASLLVSTKRLNASKFQKFVSSLNKSTIAGFASVPLRAPPSVA
FT                   FTRKKVGYSKRYVSSTNGFSATRSTVIQLLNNISTKREVEQYLKYFTSVSQQQFAVIKV
FT                   GGAIISDNLHELASCLAFLYHVGLYPIVLHGTGPQVNGRLEAQGIEPDYIDGIRITDEH
FT                   TMAVVRKCFLEQNLKLVTALEQLGVRARPITSGVFTADYLDKDKYKLVGNIKSVTKEPI
FT                   EASIKAGALPILTSLAETASGQMLNVNADVAAGELARVFEPLKIVYLNEKGGIINGSTG
FT                   EKISMINLDEEYDDLMKQSWVKYGTKLKIREIKELLDYLPRSSSVAIINVQDLQKELFT
FT                   DSGAGTMIRRGYKLVKRSSIGEFPSADALRKALQRDAGISSGKESVASYLRYLENSDFV
FT                   SYADEPLEAVAIVKKDTNVPTLDKFVCSDAAWLNNVTDNVFNVLRRDFPALQWVVSEND
FT                   ANIAWHFDKSQGSYLKGGKVLFWYGIDDINTISELVENFVKSCDTASTLNSSASSGVFA
FT                   NKKSARSYSTRSTPRPEGVNTNPGRVALIGARGYTGKNLVSLINGHPYLEVAHVSSREL
FT                   KGQKLQDYTKSEIIYESLQIQDIRKLEEQNAVDFWVMALPNKVCEPFVETIQSVHGKSK
FT                   IIDLSADHRFVSESDWAYGLPELNDRAKIANAAKIANPGCYATGSQLTISPLTKYINGL
FT                   PTVFGVSGYSGAGTKPSPKNDPKFLNNNLIPYALSDHIHEREISARIGHNVAFMPHVGQ
FT                   WFQGISLTVSIPIKKGSLSIDEIRKLYRNFYEDEKLVHVIDDIPLVKDIEGTHGVVIGG
FT                   FKLNDAEDRVVVCATIDNLLKGAATQCLQNINLAMGYGEYAGIPENKIIGV"
FT   gene            298950..301616
FT                   /gene="RNR1"
FT                   /gene_synonym="CRT7"
FT                   /gene_synonym="RIR1"
FT                   /gene_synonym="SDS12"
FT                   /locus_tag="YER070W"
FT   mRNA            298950..301616
FT                   /gene="RNR1"
FT                   /gene_synonym="CRT7"
FT                   /gene_synonym="RIR1"
FT                   /gene_synonym="SDS12"
FT                   /locus_tag="YER070W"
FT                   /product="ribonucleotide-diphosphate reductase subunit
FT                   RNR1"
FT   CDS_pept        298950..301616
FT                   /codon_start=1
FT                   /gene="RNR1"
FT                   /gene_synonym="CRT7"
FT                   /gene_synonym="RIR1"
FT                   /gene_synonym="SDS12"
FT                   /locus_tag="YER070W"
FT                   /product="ribonucleotide-diphosphate reductase subunit
FT                   RNR1"
FT                   /EC_number="1.17.4.1"
FT                   /note="Major isoform of large subunit of
FT                   ribonucleotide-diphosphate reductase; the RNR complex
FT                   catalyzes rate-limiting step in dNTP synthesis, regulated
FT                   by DNA replication and DNA damage checkpoint pathways via
FT                   localization of small subunits; relative distribution to
FT                   the nucleus increases upon DNA replication stress; RNR1 has
FT                   a paralog, RNR3, that arose from the whole genome
FT                   duplication"
FT                   /db_xref="GOA:P21524"
FT                   /db_xref="InterPro:IPR000788"
FT                   /db_xref="InterPro:IPR005144"
FT                   /db_xref="InterPro:IPR008926"
FT                   /db_xref="InterPro:IPR013346"
FT                   /db_xref="InterPro:IPR013509"
FT                   /db_xref="InterPro:IPR039718"
FT                   /db_xref="PDB:1ZYZ"
FT                   /db_xref="PDB:1ZZD"
FT                   /db_xref="PDB:2CVS"
FT                   /db_xref="PDB:2CVT"
FT                   /db_xref="PDB:2CVU"
FT                   /db_xref="PDB:2CVV"
FT                   /db_xref="PDB:2CVW"
FT                   /db_xref="PDB:2CVX"
FT                   /db_xref="PDB:2CVY"
FT                   /db_xref="PDB:2EUD"
FT                   /db_xref="PDB:2ZLF"
FT                   /db_xref="PDB:2ZLG"
FT                   /db_xref="PDB:3K8T"
FT                   /db_xref="PDB:3PAW"
FT                   /db_xref="PDB:3RSR"
FT                   /db_xref="PDB:3S87"
FT                   /db_xref="PDB:3S8A"
FT                   /db_xref="PDB:3S8B"
FT                   /db_xref="PDB:3S8C"
FT                   /db_xref="PDB:3TB9"
FT                   /db_xref="PDB:3TBA"
FT                   /db_xref="UniProtKB/Swiss-Prot:P21524"
FT                   /experiment="EXISTENCE:direct assay:GO:0000166 nucleotide
FT                   binding [PMID:16537479]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004748
FT                   ribonucleoside-diphosphate reductase activity, thioredoxin
FT                   disulfide as acceptor
FT                   [PMID:10716984|PMID:11893751|PMID:10535923]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:12732713|PMID:9315670|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005971
FT                   ribonucleoside-diphosphate reductase complex
FT                   [PMID:10716984]"
FT                   /experiment="EXISTENCE:direct assay:GO:0009263
FT                   deoxyribonucleotide biosynthetic process
FT                   [PMID:10535923|PMID:5459124]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004748
FT                   ribonucleoside-diphosphate reductase activity, thioredoxin
FT                   disulfide as acceptor [PMID:8552025]"
FT                   /protein_id="DAA07729.1"
FT                   /translation="MYVYKRDGRKEPVQFDKITARISRLCYGLDPKHIDAVKVTQRIIS
FT                   GVYEGVTTIELDNLAAETCAYMTTVHPDYATLAARIAISNLHKQTTKQFSKVVEDLYRY
FT                   VNAATGKPAPMISDDVYNIVMENKDKLNSAIVYDRDFQYSYFGFKTLERSYLLRINGQV
FT                   AERPQHLIMRVALGIHGRDIEAALETYNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVA
FT                   MKEDSIEGIYDTLKECALISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNN
FT                   TARYVDQGGNKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFMK
FT                   RVEENGTWTLFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLWYSILEAQTET
FT                   GTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDETAVCNLASVALPAFIETSE
FT                   DGKTSTYNFKKLHEIAKVVTRNLNRVIDRNYYPVEEARKSNMRHRPIALGVQGLADTFM
FT                   LLRLPFDSEEARLLNIQIFETIYHASMEASCELAQKDGPYETFQGSPASQGILQFDMWD
FT                   QKPYGMWDWDTLRKDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSNMYSRRVLS
FT                   GEFQVVNPYLLRDLVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKT
FT                   IINMAADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQAASAAIQ
FT                   FTIDQKIADQATENVADISNLKRPSYMPSSASYAASDFVPAAVTANATIPSLDSSSEAS
FT                   REASPAPTGSHSLTKGMAELNVQESKVEVPEVPAPTKNEEKAAPIVDDEETEFDIYNSK
FT                   VIACAIDNPEACEMCSG"
FT   gene            complement(301947..302327)
FT                   /gene="TDA2"
FT                   /locus_tag="YER071C"
FT   mRNA            complement(301947..302327)
FT                   /gene="TDA2"
FT                   /locus_tag="YER071C"
FT                   /product="Tda2p"
FT   CDS_pept        complement(301947..302327)
FT                   /codon_start=1
FT                   /gene="TDA2"
FT                   /locus_tag="YER071C"
FT                   /product="Tda2p"
FT                   /note="Subunit of a complex that associates with actin
FT                   filaments; forms a complex with Aim21p that inhibits barbed
FT                   end F-actin assembly; elevates actin monomer pools to
FT                   increase endocytotic efficiency and to regulate the
FT                   distribution of actin between cables and patches;
FT                   Aim21p/Tda2p forms a larger complex with actin capping
FT                   proteins Cap1p and Cap2p; TcTex1-type dynein light chain
FT                   family member; null mutant is sensitive to expression of
FT                   the top1-T722A allele"
FT                   /db_xref="GOA:P40045"
FT                   /db_xref="InterPro:IPR005334"
FT                   /db_xref="InterPro:IPR038586"
FT                   /db_xref="PDB:5VKY"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40045"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030479 actin
FT                   cortical patch [PMID:28706108|PMID:29467252]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043332 mating
FT                   projection tip [PMID:19053807]"
FT                   /experiment="EXISTENCE:direct assay:GO:0051015 actin
FT                   filament binding [PMID:29467252]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0030837
FT                   negative regulation of actin filament polymerization
FT                   [PMID:29467252]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0110131
FT                   Aim21-Tda2 complex [PMID:28706108|PMID:29467252]"
FT                   /protein_id="DAA07730.1"
FT                   /translation="MSMQIEIKDGRSDNSPLPERKLVTLIQESYDSLKDDNEINLSTES
FT                   TSNLLIKLVLEKLEKHSSLYKYIASVTTLNIEGLNEENANFSLKNDIGASWESKKDGIF
FT                   NYKLEDKNNNECYLITILWLHK"
FT   gene            302806..303195
FT                   /gene="VTC1"
FT                   /gene_synonym="NRF1"
FT                   /gene_synonym="PHM4"
FT                   /locus_tag="YER072W"
FT   mRNA            302806..303195
FT                   /gene="VTC1"
FT                   /gene_synonym="NRF1"
FT                   /gene_synonym="PHM4"
FT                   /locus_tag="YER072W"
FT                   /product="Vtc1p"
FT   CDS_pept        302806..303195
FT                   /codon_start=1
FT                   /gene="VTC1"
FT                   /gene_synonym="NRF1"
FT                   /gene_synonym="PHM4"
FT                   /locus_tag="YER072W"
FT                   /product="Vtc1p"
FT                   /note="Regulatory subunit of the vacuolar transporter
FT                   chaperone (VTC) complex; VTC complex is involved in
FT                   membrane trafficking, vacuolar polyphosphate accumulation,
FT                   microautophagy and non-autophagic vacuolar fusion; also has
FT                   mRNA binding activity; protein abundance increases in
FT                   response to DNA replication stress"
FT                   /db_xref="GOA:P40046"
FT                   /db_xref="InterPro:IPR003807"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40046"
FT                   /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
FT                   vacuole membrane [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding
FT                   [PMID:20844764]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:17079729]"
FT                   /experiment="EXISTENCE:direct assay:GO:0007034 vacuolar
FT                   transport [PMID:17079729]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016237 lysosomal
FT                   microautophagy [PMID:17079729]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031310 intrinsic
FT                   component of vacuolar membrane [PMID:12584253]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006797
FT                   polyphosphate metabolic process
FT                   [PMID:11102525|PMID:19390046]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006799
FT                   polyphosphate biosynthetic process [PMID:27252384]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar
FT                   transport [PMID:17079729]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016237
FT                   lysosomal microautophagy [PMID:17079729]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole
FT                   fusion, non-autophagic [PMID:11823419|PMID:27252384]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0033254
FT                   vacuolar transporter chaperone complex [PMID:11823419]"
FT                   /protein_id="DAA07731.1"
FT                   /translation="MSSAPLLQRTPGKKIALPTRVEPKVFFANERTFLSWLNFTVMLGG
FT                   LGVGLLNFGDKIGRVSAGLFTFVAMGTMIYALVTYHWRAAAIRRRGSGPYDDRLGPTLL
FT                   CFFLLVAVIINFILRLKYNDANTKL"
FT   gene            304030..305592
FT                   /gene="ALD5"
FT                   /locus_tag="YER073W"
FT   mRNA            304030..305592
FT                   /gene="ALD5"
FT                   /locus_tag="YER073W"
FT                   /product="aldehyde dehydrogenase (NAD(P)(+)) ALD5"
FT   CDS_pept        304030..305592
FT                   /codon_start=1
FT                   /gene="ALD5"
FT                   /locus_tag="YER073W"
FT                   /product="aldehyde dehydrogenase (NAD(P)(+)) ALD5"
FT                   /EC_number="1.2.1.5"
FT                   /note="Mitochondrial aldehyde dehydrogenase; involved in
FT                   regulation or biosynthesis of electron transport chain
FT                   components and acetate formation; activated by K+; utilizes
FT                   NADP+ as the preferred coenzyme; constitutively expressed"
FT                   /db_xref="GOA:P40047"
FT                   /db_xref="InterPro:IPR015590"
FT                   /db_xref="InterPro:IPR016160"
FT                   /db_xref="InterPro:IPR016161"
FT                   /db_xref="InterPro:IPR016162"
FT                   /db_xref="InterPro:IPR016163"
FT                   /db_xref="InterPro:IPR029510"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40047"
FT                   /experiment="EXISTENCE:direct assay:GO:0004029 aldehyde
FT                   dehydrogenase (NAD) activity [PMID:9473035]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004030 aldehyde
FT                   dehydrogenase [NAD(P)+] activity [PMID:9473035]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0019413 acetate
FT                   biosynthetic process [PMID:15256563]"
FT                   /protein_id="DAA07732.2"
FT                   /translation="MLSRTRAAAPNSRIFTRSLLRLYSQAPLRVPITLPNGFTYEQPTG
FT                   LFINGEFVASKQKKTFDVINPSNEEKITTVYKAMEDDVDEAVAAAKKAFETKWSIVEPE
FT                   VRAKALFNLADLVEKHQETLAAIESMDNGKSLFCARGDVALVSKYLRSCGGWADKIYGN
FT                   VIDTGKNHFTYSIKEPLGVCGQIIPWNFPLLMWSWKIGPALATGNTVVLKPAETTPLSA
FT                   LFASQLCQEAGIPAGVVNILPGSGRVVGERLSAHPDVKKIAFTGSTATGRHIMKVAADT
FT                   VKKVTLELGGKSPNIVFADADLDKAVKNIAFGIFYNSGEVCCAGSRIYIQDTVYEEVLQ
FT                   KLKDYTESLKVGDPFDEEVFQGAQTSDKQLHKILDYVDVAKSEGARLVTGGARHGSKGY
FT                   FVKPTVFADVKEDMRIVKEEVFGPIVTVSKFSTVDEVIAMANDSQYGLAAGIHTNDINK
FT                   AVDVSKRVKAGTVWINTYNNFHQNVPFGGFGQSGIGREMGEAALSNYTQTKSVRIAIDK
FT                   PIR"
FT   gene            306323..307196
FT                   /gene="RPS24A"
FT                   /gene_synonym="RPS24EA"
FT                   /locus_tag="YER074W"
FT   mRNA            join(306323..306325,306792..307196)
FT                   /gene="RPS24A"
FT                   /gene_synonym="RPS24EA"
FT                   /locus_tag="YER074W"
FT                   /product="ribosomal 40S subunit protein S24A"
FT   CDS_pept        join(306323..306325,306792..307196)
FT                   /codon_start=1
FT                   /gene="RPS24A"
FT                   /gene_synonym="RPS24EA"
FT                   /locus_tag="YER074W"
FT                   /product="ribosomal 40S subunit protein S24A"
FT                   /note="Protein component of the small (40S) ribosomal
FT                   subunit; homologous to mammalian ribosomal protein S24, no
FT                   bacterial homolog; RPS24A has a paralog, RPS24B, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P0CX31"
FT                   /db_xref="InterPro:IPR001976"
FT                   /db_xref="InterPro:IPR012678"
FT                   /db_xref="InterPro:IPR018098"
FT                   /db_xref="PDB:3J16"
FT                   /db_xref="PDB:3J6X"
FT                   /db_xref="PDB:3J6Y"
FT                   /db_xref="PDB:3J77"
FT                   /db_xref="PDB:3J78"
FT                   /db_xref="PDB:4U3M"
FT                   /db_xref="PDB:4U3N"
FT                   /db_xref="PDB:4U3U"
FT                   /db_xref="PDB:4U4N"
FT                   /db_xref="PDB:4U4O"
FT                   /db_xref="PDB:4U4Q"
FT                   /db_xref="PDB:4U4R"
FT                   /db_xref="PDB:4U4U"
FT                   /db_xref="PDB:4U4Y"
FT                   /db_xref="PDB:4U4Z"
FT                   /db_xref="PDB:4U50"
FT                   /db_xref="PDB:4U51"
FT                   /db_xref="PDB:4U52"
FT                   /db_xref="PDB:4U53"
FT                   /db_xref="PDB:4U55"
FT                   /db_xref="PDB:4U56"
FT                   /db_xref="PDB:4U6F"
FT                   /db_xref="PDB:4V6I"
FT                   /db_xref="PDB:4V88"
FT                   /db_xref="PDB:4V8Y"
FT                   /db_xref="PDB:4V8Z"
FT                   /db_xref="PDB:4V92"
FT                   /db_xref="PDB:5DAT"
FT                   /db_xref="PDB:5DC3"
FT                   /db_xref="PDB:5DGE"
FT                   /db_xref="PDB:5DGF"
FT                   /db_xref="PDB:5DGV"
FT                   /db_xref="PDB:5FCI"
FT                   /db_xref="PDB:5FCJ"
FT                   /db_xref="PDB:5I4L"
FT                   /db_xref="PDB:5JUO"
FT                   /db_xref="PDB:5JUP"
FT                   /db_xref="PDB:5JUS"
FT                   /db_xref="PDB:5JUT"
FT                   /db_xref="PDB:5JUU"
FT                   /db_xref="PDB:5LL6"
FT                   /db_xref="PDB:5LYB"
FT                   /db_xref="PDB:5M1J"
FT                   /db_xref="PDB:5MC6"
FT                   /db_xref="PDB:5MEI"
FT                   /db_xref="PDB:5NDG"
FT                   /db_xref="PDB:5NDV"
FT                   /db_xref="PDB:5NDW"
FT                   /db_xref="PDB:5OBM"
FT                   /db_xref="PDB:5ON6"
FT                   /db_xref="PDB:5TBW"
FT                   /db_xref="PDB:5TGA"
FT                   /db_xref="PDB:5TGM"
FT                   /db_xref="PDB:5TZS"
FT                   /db_xref="PDB:5WLC"
FT                   /db_xref="PDB:5WYJ"
FT                   /db_xref="PDB:5WYK"
FT                   /db_xref="PDB:6EML"
FT                   /db_xref="PDB:6FAI"
FT                   /db_xref="PDB:6GQ1"
FT                   /db_xref="PDB:6GQB"
FT                   /db_xref="PDB:6GQV"
FT                   /db_xref="PDB:6HHQ"
FT                   /db_xref="PDB:6I7O"
FT                   /db_xref="PDB:6Q8Y"
FT                   /db_xref="PDB:6RBD"
FT                   /db_xref="PDB:6RBE"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CX31"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000462
FT                   maturation of SSU-rRNA from tricistronic rRNA transcript
FT                   (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]"
FT                   /protein_id="DAA07733.1"
FT                   /translation="MSDAVTIRTRKVISNPLLARKQFVVDVLHPNRANVSKDELREKLA
FT                   EVYKAEKDAVSVFGFRTQFGGGKSVGFGLVYNSVAEAKKFEPTYRLVRYGLAEKVEKAS
FT                   RQQRKQKKNRDKKIFGTGKRLAKKVARRNAD"
FT   gene            307653..308123
FT                   /gene="YOS1"
FT                   /locus_tag="YER074W-A"
FT   mRNA            join(307653..307746,307849..307956,308068..308123)
FT                   /gene="YOS1"
FT                   /locus_tag="YER074W-A"
FT                   /product="Yos1p"
FT   CDS_pept        join(307653..307746,307849..307956,308068..308123)
FT                   /codon_start=1
FT                   /gene="YOS1"
FT                   /locus_tag="YER074W-A"
FT                   /product="Yos1p"
FT                   /note="Integral membrane protein required for ER to Golgi
FT                   transport; localized to the Golgi, the ER, and COPII
FT                   vesicles; interacts with Yip1p and Yif1p"
FT                   /db_xref="EnsemblGenomes-Gn:YER074W-A"
FT                   /db_xref="EnsemblGenomes-Tr:YER074W-A"
FT                   /db_xref="GOA:Q3E834"
FT                   /db_xref="InterPro:IPR013880"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q3E834"
FT                   /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
FT                   reticulum membrane [PMID:15659647]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated
FT                   ER to Golgi transport vesicle [PMID:15659647]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030173 integral
FT                   component of Golgi membrane [PMID:15659647]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006888
FT                   endoplasmic reticulum to Golgi vesicle-mediated transport
FT                   [PMID:15659647]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005789
FT                   endoplasmic reticulum membrane [PMID:15659647]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0030134
FT                   COPII-coated ER to Golgi transport vesicle [PMID:15659647]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0030173
FT                   integral component of Golgi membrane [PMID:15659647]"
FT                   /protein_id="DAA07734.1"
FT                   /translation="MVLFGLGRLFYVILLLINAVAVLSEERFLRRIGLGRSNDETPVFG
FT                   QDQNTTKSKVVQLIGAVQTLLRIPLIGINILVIVYELLLG"
FT   gene            complement(308413..311199)
FT                   /gene="PTP3"
FT                   /locus_tag="YER075C"
FT   mRNA            complement(308413..311199)
FT                   /gene="PTP3"
FT                   /locus_tag="YER075C"
FT                   /product="tyrosine protein phosphatase PTP3"
FT   CDS_pept        complement(308413..311199)
FT                   /codon_start=1
FT                   /gene="PTP3"
FT                   /locus_tag="YER075C"
FT                   /product="tyrosine protein phosphatase PTP3"
FT                   /EC_number="3.1.3.48"
FT                   /note="Phosphotyrosine-specific protein phosphatase; major
FT                   role in the pheromone adaptive response through
FT                   dephosphorylation of the Fus3p MAPK with a minor role by
FT                   Ptp2p and Msg5p; minor role in the inactivation of Hog1p
FT                   MAPK during osmolarity sensing with major role by Ptp2p;
FT                   dephosphorylates and regulates the localization of Hog1p;
FT                   minor role in the cell wall integrity pathway through
FT                   tyrosine dephosphorylation of the MAPK Slt2p while Ptp2p
FT                   plays a major role; localizes to the cytoplasm"
FT                   /db_xref="GOA:P40048"
FT                   /db_xref="InterPro:IPR000242"
FT                   /db_xref="InterPro:IPR000387"
FT                   /db_xref="InterPro:IPR001763"
FT                   /db_xref="InterPro:IPR003595"
FT                   /db_xref="InterPro:IPR016130"
FT                   /db_xref="InterPro:IPR029021"
FT                   /db_xref="InterPro:IPR036873"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40048"
FT                   /experiment="EXISTENCE:direct assay:GO:0004725 protein
FT                   tyrosine phosphatase activity [PMID:9224718]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:17952059]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:10523653|PMID:17952059]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035335
FT                   peptidyl-tyrosine dephosphorylation [PMID:9224718]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000188
FT                   inactivation of MAPK activity
FT                   [PMID:9032256|PMID:9211927|PMID:10523653|PMID:9224718]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0035335
FT                   peptidyl-tyrosine dephosphorylation
FT                   [PMID:10523653|PMID:9224718]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0043937
FT                   regulation of sporulation [PMID:10679022]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000188
FT                   inactivation of MAPK activity [PMID:10557209]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0035335
FT                   peptidyl-tyrosine dephosphorylation [PMID:9224718]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051220
FT                   cytoplasmic sequestering of protein [PMID:10817757]"
FT                   /protein_id="DAA07735.2"
FT                   /translation="MKDSVDCPSILPTDRTSVLSETSTLVGSSSHVYSRHAPMNSYHNS
FT                   MNSNIYHSPKASSPLVSYKTSSPVLLKRATAPVLPSFKPKEQRYNKPQGCSLITAVELG
FT                   KIIETLPDEKVLLLDVRPFTEHAKSIITNSIHVCLPSTLLRRKNFTFSKLLDNLTPSEQ
FT                   SVLKSKLAIDNLRIIIYDSTANQTESSVSLPCYGIASKLIEFDTNVKKTVSILMCGFPQ
FT                   FKILFPDHINTNTFNSDCISSAEPKSPKTNLMNSLHNTAPHMTATTPLSSPQMNLKLKV
FT                   PDDSRSDHSNFSSSPSPRNVLSDSPMSSSSPISALFKFQLPAPQTNINQMFKFSQNEEI
FT                   MGLETYLSAVNIKEEHERWYNNDSAKKSLQNFQFPKNQNSLEKDTNKDKLGFQIRYENL
FT                   SKNYEKEVIDSVIPEWFQHLMSIPKIELVSQFQKLDFLEKRRLNHSVSFRKKENSFILE
FT                   KPSSYPEQLTSTSSSTIMPPKFPDVNKVQKRSHSQPIFTQYSKYKSMLSLESDSDSESD
FT                   DVIISSGVELGAKNRYKDIFPYEHSRVILKKGLQSSKGIKHSHSTSDGGILDNYINANY
FT                   LSLPRFSVEQNSSFQTTTTTTRRVRYIATQAPMPSTVHDFYTCILNNGVPLVLSLTNDF
FT                   ENGIEKCYRYWQEGNYNGIHVKLLEKKILKMPSTTSMRKNTMGTQNSSLYSAGVQGNSS
FT                   NYSTDNDNDNDNNNNNNNNSNIAVTAAACDDDDDDDDDAILIRKILLTYHDQEKPYELL
FT                   QIQVKNWPDLGTLLNPISILQAINVKNHIIDTLFARNYYQNDQLPTILVHCSAGCGRTG
FT                   TLCTIDSILSNFEMFEMLQKEFVKLKYPAKLFDPISWTINIFRKQRISMVQNINQFIFI
FT                   YDCLLFYFRLRLDDITERTDGDGSNKDNISLSALIEQIEKLEILQTFVDDKLKELPQ"
FT   gene            complement(312023..312095)
FT                   /locus_tag="tA(UGC)E"
FT   tRNA            complement(312023..312095)
FT                   /locus_tag="tA(UGC)E"
FT                   /product="tRNA-Ala"
FT                   /note="tA(UGC)E; Alanine tRNA (tRNA-Ala), predicted by
FT                   tRNAscan-SE analysis; one of 5 nuclear tRNA genes
FT                   containing the tDNA-anticodon TGC (mature tRNA may be UGC
FT                   or may contain modified bases), decodes GCA and probably
FT                   GCG codons into alanine, one of 16 nuclear tRNAs for
FT                   alanine"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   repeat_region   312274..312445
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            complement(312590..313498)
FT                   /locus_tag="YER076C"
FT   mRNA            complement(312590..313498)
FT                   /locus_tag="YER076C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(312590..313498)
FT                   /codon_start=1
FT                   /locus_tag="YER076C"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; the authentic, non-tagged
FT                   protein is detected in highly purified mitochondria in
FT                   high-throughput studies; analysis of HA-tagged protein
FT                   suggests a membrane localization"
FT                   /db_xref="GOA:P40049"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40049"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /protein_id="DAA07736.1"
FT                   /translation="MTSGYYTVSFFYAILLLCACTRAEIYLTGGESQGLPSGFWQMDDD
FT                   LAIAPVSMVEFYQTIGLTANGTVPESFNKRDATEYPNIISNITTQAANFTQHSLVEQLQ
FT                   NDVTAISISNAINVAVDGSVETPADLQYNRNQETGESTLCRAKFYGVEVRTWSRLYNRA
FT                   VSSTTLTTNLNSYIAQWVAWAVHGSGDKKFCGSQEFTNIFFDGQEGWSLFVKTWSTNSS
FT                   CDITASEGNLTCAVRVSVSSMHNHGKTAFCVTYSHGDSWRAELRVVANDAWSHYYPWSI
FT                   DCPEVDKNNMAINDCFDQAQG"
FT   gene            complement(314534..316600)
FT                   /gene="MRX1"
FT                   /locus_tag="YER077C"
FT   mRNA            complement(314534..316600)
FT                   /gene="MRX1"
FT                   /locus_tag="YER077C"
FT                   /product="Mrx1p"
FT   CDS_pept        complement(314534..316600)
FT                   /codon_start=1
FT                   /gene="MRX1"
FT                   /locus_tag="YER077C"
FT                   /product="Mrx1p"
FT                   /note="Protein that associates with mitochondrial ribosome;
FT                   green fluorescent protein (GFP)-fusion protein localizes to
FT                   the mitochondrion; null mutation results in a decrease in
FT                   plasma membrane electron transport"
FT                   /db_xref="GOA:P40050"
FT                   /db_xref="InterPro:IPR002885"
FT                   /db_xref="InterPro:IPR011990"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40050"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14562095|PMID:24769239]"
FT                   /protein_id="DAA07737.1"
FT                   /translation="MGLKITKGQLRTKDLNQSSSKSSQSSRIGVDTCIFTRMLPRINTA
FT                   INLTEHLLRRSFHSLTNLQKTQVKERLHELERHGFILNKTSKQLERINSKKRRQLKKLQ
FT                   KTAYPKDQAFHILRKFHKINNEALADTKLGPTSQSDLKFLSLTKDKRLFYTILGVNGEQ
FT                   LRDSKLIANDVQKFLKRGQLEKAVFLARLAKKKGVVGMNLIMKYYIEVVQSQQSAVDIF
FT                   NWRKKWGVPIDQHSITILFNGLSKQENLVSKKYGELVLKTIDSLCDKNELTEIEYNTAL
FT                   AALINCTDETLVFKLLNKKCPGLKKDSITYTLMIRSCTRIADEKRFMVVLNDLMNKIPD
FT                   YCVDSKLLFEYCEVICSQKSPKIEKQGMGLWALCEYFQFDKTIFKKYLTQSDFPTLVPL
FT                   SHWNINKPFPLNKHVVGLFMNYCLKNKEYDLAMEIFKTLEAQNNQMLDQSIYHKYMETV
FT                   ITTRPITCGDECLDIYERVASSAQISITRRTLILVYNAFQRQSLKAVINKDASNAEATL
FT                   HKIRGFIDSVEATYSSKLNGKVYRFNSWKFLFPIVKNLNMNDKVSTVELKSILDEYLKS
FT                   LLNGEFGKEFKASIEDKRFVTLEGIRLVKVLTERIKLPSLDSEEIASLKGTERKKFLAR
FT                   RHLLRLKQILLEDLADIEGNSRRKGDSENTSTSEERIMEDLAELILETSYDKF"
FT   rep_origin      316600..316807
FT                   /note="ARS515; Autonomously Replicating Sequence"
FT   gene            complement(316807..318342)
FT                   /gene="ICP55"
FT                   /locus_tag="YER078C"
FT   mRNA            complement(316807..318342)
FT                   /gene="ICP55"
FT                   /locus_tag="YER078C"
FT                   /product="aminopeptidase"
FT   CDS_pept        complement(316807..318342)
FT                   /codon_start=1
FT                   /gene="ICP55"
FT                   /locus_tag="YER078C"
FT                   /product="aminopeptidase"
FT                   /EC_number="3.4.11.26"
FT                   /note="Mitochondrial aminopeptidase; cleaves the N termini
FT                   of at least 38 imported proteins after cleavage by the
FT                   mitochondrial processing peptidase (MPP), thereby
FT                   increasing their stability; member of the aminopeptidase P
FT                   family"
FT                   /db_xref="GOA:P40051"
FT                   /db_xref="InterPro:IPR000994"
FT                   /db_xref="InterPro:IPR001131"
FT                   /db_xref="InterPro:IPR007865"
FT                   /db_xref="InterPro:IPR029149"
FT                   /db_xref="InterPro:IPR036005"
FT                   /db_xref="PDB:6A9T"
FT                   /db_xref="PDB:6A9U"
FT                   /db_xref="PDB:6A9V"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40051"
FT                   /experiment="EXISTENCE:direct assay:GO:0004177
FT                   aminopeptidase activity [PMID:19720832]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:19720832]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion
FT                   [PMID:19720832|PMID:14562095|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031314 extrinsic
FT                   component of mitochondrial inner membrane [PMID:19837041]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0016485
FT                   protein processing [PMID:19837041]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004177
FT                   aminopeptidase activity [PMID:19720832|PMID:19837041]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016485 protein
FT                   processing [PMID:19720832|PMID:19837041]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein
FT                   stabilization [PMID:19837041]"
FT                   /protein_id="DAA07738.1"
FT                   /translation="MLHRINPVRFSMQSCQRYFSKLVSPLEQHKSNTFTNRVRIPIEAG
FT                   QPLHETRPFLIKSGELTPGISALEYYERRIRLAETLPPKSCVILAGNDIQFASGAVFYP
FT                   FQQENDLFYLSGWNEPNSVMILEKPTDSLSDTIFHMLVPPKDAFAEKWEGFRSGVYGVQ
FT                   EIFNADESASINDLSKYLPKIINRNDFIYFDMLSTSNPSSSNFKHIKSLLDGSGNSNRS
FT                   LNSIANKTIKPISKRIAEFRKIKSPQELRIMRRAGQISGRSFNQAFAKRFRNERTLDSF
FT                   LHYKFISGGCDKDAYIPVVATGSNSLCIHYTRNDDVMFDDEMVLVDAAGSLGGYCADIS
FT                   RTWPNSGKFTDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQELKNLGI
FT                   DKVSGWNVEKLYPHYIGHNLGLDVHDVPKVSRYEPLKVGQVITIEPGLYIPNEESFPSY
FT                   FRNVGIRIEDDIAIGEDTYTNLTVEAVKEIDDLENVMQNGLSTKFEEDQVAPL"
FT   gene            318646..318810
FT                   /locus_tag="YER078W-A"
FT   mRNA            318646..318810
FT                   /locus_tag="YER078W-A"
FT                   /product="hypothetical protein"
FT   CDS_pept        318646..318810
FT                   /codon_start=1
FT                   /locus_tag="YER078W-A"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; identified by fungal homology
FT                   and RT-PCR"
FT                   /db_xref="EnsemblGenomes-Gn:YER078W-A"
FT                   /db_xref="EnsemblGenomes-Tr:YER078W-A"
FT                   /db_xref="GOA:Q3E7A2"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q3E7A2"
FT                   /protein_id="DAA07739.1"
FT                   /translation="MVRLSYLRLILPPCRLSELSSLAILYQPVIPILISTITFQHFFKC
FT                   VHTPCNVYI"
FT   gene            318920..319552
FT                   /locus_tag="YER079W"
FT   mRNA            318920..319552
FT                   /locus_tag="YER079W"
FT                   /product="hypothetical protein"
FT   CDS_pept        318920..319552
FT                   /codon_start=1
FT                   /locus_tag="YER079W"
FT                   /product="hypothetical protein"
FT                   /db_xref="GOA:P40052"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40052"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /protein_id="DAA07740.1"
FT                   /translation="MPDSSHSISSKDVASAISLYDQSIYTNNRSTNLDLDQRSMSPSNI
FT                   ASGEDRITRTNSGCSITSGASMIATKDGIQGINVKRDGIPKYSLNLLNSMVRKQYDHNN
FT                   GTKSPTPKTSNMVDPKNKKKNKKKKNDKDDKYKVSHDQTEKFYKLNTTSNSNLTSDSTT
FT                   SLSDQFYFQKSNADSAPLDNANYPLSDHSPSLNSMDNTTKHSSNVHT"
FT   gene            319963..321846
FT                   /gene="AIM9"
FT                   /gene_synonym="FMP29"
FT                   /locus_tag="YER080W"
FT   mRNA            319963..321846
FT                   /gene="AIM9"
FT                   /gene_synonym="FMP29"
FT                   /locus_tag="YER080W"
FT                   /product="Aim9p"
FT   CDS_pept        319963..321846
FT                   /codon_start=1
FT                   /gene="AIM9"
FT                   /gene_synonym="FMP29"
FT                   /locus_tag="YER080W"
FT                   /product="Aim9p"
FT                   /note="hypothetical protein; the authentic, non-tagged
FT                   protein is detected in highly purified mitochondria in
FT                   high-throughput studies; null mutant displays elevated
FT                   frequency of mitochondrial genome loss"
FT                   /db_xref="GOA:P40053"
FT                   /db_xref="InterPro:IPR002575"
FT                   /db_xref="InterPro:IPR011009"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40053"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion
FT                   [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]"
FT                   /protein_id="DAA07741.1"
FT                   /translation="MIRYTVAGHSRRCVVGASKRVGAIKCITVAATKRFISNKPNEVFT
FT                   KLTNDNDPKRDAFFKYTWGSWLKNDKQEKEKRFTKFSIEGLNRILNDIYIQSNEMAKAP
FT                   DGKILPPVFNKNLTVSLVNNVVPKNIGKINPNEKVQVTTLSSIHEGKHHRIYKVDTNLN
FT                   KAFILRIPYPLENENTLSYRIRSEVATMDFADLKLGIKVPKIFCYGVNSLNPVRQPFVL
FT                   QEFIEGELLMKDWDPLIEDGSSNQKKYDNVIKQVSDFQSKLVSLKLNAFGSIYFNNDLK
FT                   DGNEKEFVKEDIYDGETNPDLQNRWKIGPSVERCLWRHKSHLDFHKQMKPFLGPWPKKS
FT                   PMDIIKNTGLLEAENAKTRIAMKEAGSSAELMYPRTLKEQITTYENLAKIAPDLFNVKT
FT                   KAIPNMQELLSPRLFHPDLDPMNIIVNKEAQEAYLLDFEGACTKPFILQNSPQFIAYDG
FT                   PKIYDLKEDITDFDKLSEAEKVQYQFMYKRTRNQHQWEKKLNDNNPKLITAVAPPVKLL
FT                   RSPYIAAVERKTEEEYLLIDESLLQLKEVWDIFAQNELVNQKKFPLNYSKEDIERHVED
FT                   LQKLHEKLISTPFAATQGWIPQDMFDQLLNSGSIVKQENGDYTVKQPEATK"
FT   gene            322212..322762
FT                   /locus_tag="SRG1"
FT   ncRNA           322212..322762
FT                   /locus_tag="SRG1"
FT                   /product="SRG1"
FT                   /note="Non-protein-coding RNA that regulates the
FT                   transcription of SER3; expression of SRG1 RNA represses
FT                   expression of its neighboring gene SER3 via a
FT                   transcription-interference mechanism"
FT                   /experiment="EXISTENCE:curator inference:GO:0005634 nucleus
FT                   [PMID:15175754]"
FT                   /experiment="EXISTENCE:expression pattern:GO:0045892
FT                   negative regulation of transcription, DNA-templated
FT                   [PMID:15175754]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045892 negative
FT                   regulation of transcription, DNA-templated [PMID:15175754]"
FT                   /ncRNA_class="other"
FT   gene            322686..324095
FT                   /gene="SER3"
FT                   /locus_tag="YER081W"
FT   mRNA            322686..324095
FT                   /gene="SER3"
FT                   /locus_tag="YER081W"
FT                   /product="phosphoglycerate dehydrogenase SER3"
FT   CDS_pept        322686..324095
FT                   /codon_start=1
FT                   /gene="SER3"
FT                   /locus_tag="YER081W"
FT                   /product="phosphoglycerate dehydrogenase SER3"
FT                   /EC_number="1.1.1.95"
FT                   /EC_number="1.1.1.399"
FT                   /note="3-phosphoglycerate dehydrogenase and
FT                   alpha-ketoglutarate reductase; 3PG dehydrogenase that
FT                   catalyzes the first step in serine and glycine
FT                   biosynthesis; also functions as an alpha-ketoglutarate
FT                   reductase, converting alpha-ketoglutarate to
FT                   D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm;
FT                   SER3 has a paralog, SER33, that arose from the whole genome
FT                   duplication"
FT                   /db_xref="GOA:P40054"
FT                   /db_xref="InterPro:IPR002912"
FT                   /db_xref="InterPro:IPR006139"
FT                   /db_xref="InterPro:IPR006140"
FT                   /db_xref="InterPro:IPR029015"
FT                   /db_xref="InterPro:IPR029752"
FT                   /db_xref="InterPro:IPR029753"
FT                   /db_xref="InterPro:IPR036291"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40054"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0061759
FT                   alpha-ketoglutarate reductase activity [PMID:26774271]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0061759
FT                   alpha-ketoglutarate reductase activity [PMID:26774271]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004617
FT                   phosphoglycerate dehydrogenase activity [PMID:12525494]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009070 serine
FT                   family amino acid biosynthetic process [PMID:12525494]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0061759
FT                   alpha-ketoglutarate reductase activity [PMID:26774271]"
FT                   /protein_id="DAA07742.1"
FT                   /translation="MTSIDINNLQNTFQQAMNMSGSPGAVCTSPTQSFMNTVPQRLNAV
FT                   KHPKILKPFSTGDMKILLLENVNQTAITIFEEQGYQVEFYKSSLPEEELIEKIKDVHAI
FT                   GIRSKTRLTSNVLQHAKNLVCIGCFCIGTNQVDLDYATSRGIAVFNSPFSNSRSVAELV
FT                   IAEIISLARQLGDRSIELHTGTWNKVAARCWEVRGKTLGIIGYGHIGSQLSVLAEAMGL
FT                   HVLYYDIVTIMALGTARQVSTLDELLNKSDFVTLHVPATPETEKMLSAPQFAAMKDGAY
FT                   VINASRGTVVDIPSLIQAVKANKIAGAALDVYPHEPAKNGEGSFNDELNSWTSELVSLP
FT                   NIILTPHIGGSTEEAQSSIGIEVATALSKYINEGNSVGSVNFPEVALKSLSYDQENTVR
FT                   VLYIHQNVPGVLKTVNDILSNHNIEKQFSDSNGEIAYLMADISSVDQSDIKDIYEQLNQ
FT                   TSAKISIRLLY"
FT   gene            complement(324272..325936)
FT                   /gene="UTP7"
FT                   /gene_synonym="KRE31"
FT                   /locus_tag="YER082C"
FT   mRNA            complement(324272..325936)
FT                   /gene="UTP7"
FT                   /gene_synonym="KRE31"
FT                   /locus_tag="YER082C"
FT                   /product="Utp7p"
FT   CDS_pept        complement(324272..325936)
FT                   /codon_start=1
FT                   /gene="UTP7"
FT                   /gene_synonym="KRE31"
FT                   /locus_tag="YER082C"
FT                   /product="Utp7p"
FT                   /note="Nucleolar protein; component of the small subunit
FT                   (SSU) processome containing the U3 snoRNA that is involved
FT                   in processing of pre-18S rRNA"
FT                   /db_xref="GOA:P40055"
FT                   /db_xref="InterPro:IPR001680"
FT                   /db_xref="InterPro:IPR012952"
FT                   /db_xref="InterPro:IPR015943"
FT                   /db_xref="InterPro:IPR017986"
FT                   /db_xref="InterPro:IPR019775"
FT                   /db_xref="InterPro:IPR036322"
FT                   /db_xref="InterPro:IPR040315"
FT                   /db_xref="PDB:5WLC"
FT                   /db_xref="PDB:6ND4"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40055"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:12068309|PMID:12150911]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030686 90S
FT                   preribosome [PMID:12150911]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030688 preribosome,
FT                   small subunit precursor [PMID:15167894]"
FT                   /experiment="EXISTENCE:direct assay:GO:0032040
FT                   small-subunit processome [PMID:12068309]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000447
FT                   endonucleolytic cleavage in ITS1 to separate SSU-rRNA from
FT                   5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript
FT                   (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FT                   [PMID:15489292|PMID:15590835]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000462
FT                   maturation of SSU-rRNA from tricistronic rRNA transcript
FT                   (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000472
FT                   endonucleolytic cleavage to generate mature 5'-end of
FT                   SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FT                   [PMID:15489292|PMID:15590835]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000480
FT                   endonucleolytic cleavage in 5'-ETS of tricistronic rRNA
FT                   transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FT                   [PMID:15489292|PMID:15590835]"
FT                   /protein_id="DAA07743.1"
FT                   /translation="MGHKKNGHRRQIKERENQNKFERSTYTNNAKNNHTQTKDKKLRAG
FT                   LKKIDEQYKKAVSSAAATDYLLPESNGYLEPENELEKTFKVQQSEIKSSVDVSTANKAL
FT                   DLSLKEFGPYHIKYAKNGTHLLITGRKGHVASMDWRKGQLRAELFLNETCHSATYLQNE
FT                   QYFAVAQKKYTFIYDHEGTELHRLKQHIEARHLDFLPYHYLLVTAGETGWLKYHDVSTG
FT                   QLVSELRTKAGPTMAMAQNPWNAVMHLGHSNGTVSLWSPSMPEPLVKLLSARGPVNSIA
FT                   IDRSGYYMATTGADRSMKIWDIRNFKQLHSVESLPTPGTNVSISDTGLLALSRGPHVTL
FT                   WKDALKLSGDSKPCFGSMGGNPHRNTPYMSHLFAGNKVENLGFVPFEDLLGVGHQTGIT
FT                   NLIVPGAGEANYDALELNPFETKKQRQEQEVRTLLNKLPADTITLDPNSIGSVDKRSST
FT                   IRLNAKDLAQTTMDANNKAKTNSDIPDVKPDVKGKNSGLRSFLRKKTQNVIDERKLRVQ
FT                   KQLDKEKNIRKRNHQIKQGLISEDHKDVIEEALSRFG"
FT   gene            complement(326174..327031)
FT                   /gene="GET2"
FT                   /gene_synonym="HUR2"
FT                   /gene_synonym="RMD7"
FT                   /locus_tag="YER083C"
FT   mRNA            complement(326174..327031)
FT                   /gene="GET2"
FT                   /gene_synonym="HUR2"
FT                   /gene_synonym="RMD7"
FT                   /locus_tag="YER083C"
FT                   /product="GET complex subunit GET2"
FT   CDS_pept        complement(326174..327031)
FT                   /codon_start=1
FT                   /gene="GET2"
FT                   /gene_synonym="HUR2"
FT                   /gene_synonym="RMD7"
FT                   /locus_tag="YER083C"
FT                   /product="GET complex subunit GET2"
FT                   /note="Subunit of the GET complex; involved in insertion of
FT                   proteins into the ER membrane; required for the retrieval
FT                   of HDEL proteins from the Golgi to the ER in an ERD2
FT                   dependent fashion and for meiotic nuclear division"
FT                   /db_xref="GOA:P40056"
FT                   /db_xref="InterPro:IPR014802"
FT                   /db_xref="InterPro:IPR028143"
FT                   /db_xref="PDB:3SJD"
FT                   /db_xref="PDB:3ZS9"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40056"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:14562095|PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006890 retrograde
FT                   vesicle-mediated transport, Golgi to endoplasmic reticulum
FT                   [PMID:16269340]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006890
FT                   retrograde vesicle-mediated transport, Golgi to endoplasmic
FT                   reticulum [PMID:16269340]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0043495
FT                   protein membrane anchor [PMID:18724936]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0043529 GET
FT                   complex [PMID:16269340]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0045048
FT                   protein insertion into ER membrane [PMID:18724936]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006890
FT                   retrograde vesicle-mediated transport, Golgi to endoplasmic
FT                   reticulum [PMID:16269340]"
FT                   /protein_id="DAA07744.1"
FT                   /translation="MSELTEAEKRRLLRERRQKKFSNGGASSRLNKITGQASSHLNAES
FT                   PLDAPSAAKTTPPASVHSATPDIKEDSNVAPQLDLLKQLAAMQGQGTGKSTPQDSSTPD
FT                   LLSLLSSMNTGMPSAEGTPSFGQAAPAAPINQAALDYHDYLLNRLKAWTILVKWVFFLL
FT                   PYLYLITRPNSSVWPAYAFTQSAWFAPLRNPSNFTRIFATFEFLSISIYYQLLKNVEHK
FT                   SKIKNLQDTNKLVKLVSLVPEGVIPVANLKGKLITLLQYWDLLSMLITDISFVLIVLGL
FT                   LTYL"
FT   gene            327065..327451
FT                   /locus_tag="YER084W"
FT   mRNA            327065..327451
FT                   /locus_tag="YER084W"
FT                   /product="hypothetical protein"
FT   CDS_pept        327065..327451
FT                   /codon_start=1
FT                   /locus_tag="YER084W"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; expressed at both mRNA and
FT                   protein levels"
FT                   /db_xref="GOA:P40057"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40057"
FT                   /protein_id="DAA35103.1"
FT                   /translation="MEELICTYPYHSNLFMFLFLFFCPSKRARRGHPKFLFTLCYKSNH
FT                   LIPKLLPPSLFTKRVMLNPSSHPPSPDFPTGSSASPRVKLRPSTLWAPPLTVSSDFAAS
FT                   SSSTAPVTVTDKPVTPAVSKRYQP"
FT   gene            complement(327619..328140)
FT                   /locus_tag="YER085C"
FT   mRNA            complement(327619..328140)
FT                   /locus_tag="YER085C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(327619..328140)
FT                   /codon_start=1
FT                   /locus_tag="YER085C"
FT                   /product="hypothetical protein"
FT                   /db_xref="GOA:P40058"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40058"
FT                   /protein_id="DAA07745.1"
FT                   /translation="MNFKEPLVNFLKCVLNNINSAFSHRIDQLQLQLLRETNILRVLNR
FT                   GIERLFSENPRTHSVSRIVVEKDVGCRIGRYVEGSKYELVESRAKEIQIYYERMVFEIT
FT                   QELKGDKRVFALIANLSQRYSAERKEIRNVKVHGGRPCNENEFQVIPIRFKPINLERRA
FT                   RLIRKKKTIN"
FT   gene            328477..330207
FT                   /gene="ILV1"
FT                   /gene_synonym="ISO1"
FT                   /locus_tag="YER086W"
FT   mRNA            328477..330207
FT                   /gene="ILV1"
FT                   /gene_synonym="ISO1"
FT                   /locus_tag="YER086W"
FT                   /product="threonine ammonia-lyase ILV1"
FT   CDS_pept        328477..330207
FT                   /codon_start=1
FT                   /gene="ILV1"
FT                   /gene_synonym="ISO1"
FT                   /locus_tag="YER086W"
FT                   /product="threonine ammonia-lyase ILV1"
FT                   /EC_number="4.3.1.19"
FT                   /note="Threonine deaminase, catalyzes first step in
FT                   isoleucine biosynthesis; expression is under general amino
FT                   acid control; ILV1 locus exhibits highly positioned
FT                   nucleosomes whose organization is independent of known ILV1
FT                   regulation"
FT                   /db_xref="GOA:P00927"
FT                   /db_xref="InterPro:IPR000634"
FT                   /db_xref="InterPro:IPR001721"
FT                   /db_xref="InterPro:IPR001926"
FT                   /db_xref="InterPro:IPR005787"
FT                   /db_xref="InterPro:IPR036052"
FT                   /db_xref="InterPro:IPR038110"
FT                   /db_xref="UniProtKB/Swiss-Prot:P00927"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion
FT                   [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006567
FT                   threonine catabolic process [PMID:7042346]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004794
FT                   L-threonine ammonia-lyase activity [PMID:5345980]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009097
FT                   isoleucine biosynthetic process [PMID:5345980]"
FT                   /protein_id="DAA07746.1"
FT                   /translation="MSATLLKQPLCTVVRQGKQSKVSGLNLLRLKAHLHRQHLSPSLIK
FT                   LHSELKLDELQTDNTPDYVRLVLRSSVYDVINESPISQGVGLSSRLNTNVILKREDLLP
FT                   VFSFKLRGAYNMIAKLDDSQRNQGVIACSAGNHAQGVAFAAKHLKIPATIVMPVCTPSI
FT                   KYQNVSRLGSQVVLYGNDFDEAKAECAKLAEERGLTNIPPFDHPYVIAGQGTVAMEILR
FT                   QVRTANKIGAVFVPVGGGGLIAGIGAYLKRVAPHIKIIGVETYDAATLHNSLQRNQRTP
FT                   LPVVGTFADGTSVRMIGEETFRVAQQVVDEVVLVNTDEICAAVKDIFEDTRSIVEPSGA
FT                   LSVAGMKKYISTVHPEIDHTKNTYVPILSGANMNFDRLRFVSERAVLGEGKEVFMLVTL
FT                   PDVPGAFKKMQKIIHPRSVTEFSYRYNEHRHESSSEVPKAYIYTSFSVVDREKEIKQVM
FT                   QQLNALGFEAVDISDNELAKSHGRYLVGGASKVPNERIISFEFPERPGALTRFLGGLSD
FT                   SWNLTLFHYRNHGADIGKVLAGISVPPRENLTFQKFLEDLGYTYHDETDNTVYQKFLKY
FT                   "
FT   gene            330576..332306
FT                   /gene="AIM10"
FT                   /locus_tag="YER087W"
FT   mRNA            330576..332306
FT                   /gene="AIM10"
FT                   /locus_tag="YER087W"
FT                   /product="putative proline--tRNA ligase AIM10"
FT   CDS_pept        330576..332306
FT                   /codon_start=1
FT                   /gene="AIM10"
FT                   /locus_tag="YER087W"
FT                   /product="putative proline--tRNA ligase AIM10"
FT                   /EC_number="6.1.1.15"
FT                   /note="Protein with similarity to tRNA synthetases;
FT                   non-tagged protein is detected in purified mitochondria;
FT                   null mutant is viable and displays elevated frequency of
FT                   mitochondrial genome loss"
FT                   /db_xref="GOA:P39965"
FT                   /db_xref="InterPro:IPR002314"
FT                   /db_xref="InterPro:IPR002316"
FT                   /db_xref="InterPro:IPR004500"
FT                   /db_xref="InterPro:IPR006195"
FT                   /db_xref="InterPro:IPR033730"
FT                   /db_xref="InterPro:IPR036621"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39965"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961|PMID:24769239]"
FT                   /protein_id="DAA07747.1"
FT                   /translation="MLKYRTLSRSCHIFHPKSLSNNTLKSETTQELLQTVGFVRRSQVG
FT                   LFQWLPLGLRSLNKVSNAIRNRMDSDGGAIEVSLSAISSKALWQATDRWNNSELFKLKD
FT                   SKGKQYCLTATCEEDITDLMKNYIASYKDMPITIYQMTRKYRDEIRPRGGILRGREFLM
FT                   KDAYSFASNEEDAFASFQKLDDTYNKIFKDLKIPFVSAWADSGDIGGEFSKEFHLIHES
FT                   GEDTLMSCKHCGDISTLDMSQSYPEKDGQYSGDVDCKYALTKDHSTLICFYYPKDRQLN
FT                   WNLALNAMDKDIDLTLRNKPNDHVLQVYEKDNEDIMFSKILRVMDCRLNSKSNFPDFPL
FT                   KKYLKNNFGQISDVSIVDAQENEICGKCEEGRLEPLKSIEVGHIFLLGNKYSKPLNVKF
FT                   VDKENKNETFVHMGCYGIGVSRLVGAIAELGRDSNGFRWPAIMAPYKVSICTGPNNPEN
FT                   SQRLQDVKSELLNDPTMQNLQNDILDQFNEKLGIGARIKLSHAMGIPLCVIVGSKSWPN
FT                   VEIEVRGIRWGEKDLWRKQFEKRCSELQWKCTKNEHGIEKHTVPIQHLAEVIGVLLKDM
FT                   "
FT   gene            complement(332582..332830)
FT                   /gene="SBH1"
FT                   /gene_synonym="SEB1"
FT                   /gene_synonym="YER087C-A"
FT                   /locus_tag="YER087C-B"
FT   mRNA            complement(332582..332830)
FT                   /gene="SBH1"
FT                   /gene_synonym="SEB1"
FT                   /gene_synonym="YER087C-A"
FT                   /locus_tag="YER087C-B"
FT                   /product="Arf family guanine nucleotide exchange factor
FT                   SBH1"
FT   CDS_pept        complement(332582..332830)
FT                   /codon_start=1
FT                   /gene="SBH1"
FT                   /gene_synonym="SEB1"
FT                   /gene_synonym="YER087C-A"
FT                   /locus_tag="YER087C-B"
FT                   /product="Arf family guanine nucleotide exchange factor
FT                   SBH1"
FT                   /note="Beta subunit of Sec61p ER translocation complex
FT                   (Sec61p-Sss1p-Sbh1p); involved in protein translocation
FT                   into the endoplasmic reticulum; interacts with the exocyst
FT                   complex and also with Rtn1p; cotranslationally N-acetylated
FT                   by NatA; SBH1 has a paralog, SBH2, that arose from the
FT                   whole genome duplication"
FT                   /db_xref="GOA:P52870"
FT                   /db_xref="InterPro:IPR016482"
FT                   /db_xref="InterPro:IPR030671"
FT                   /db_xref="PDB:6N3Q"
FT                   /db_xref="PDB:6ND1"
FT                   /db_xref="UniProtKB/Swiss-Prot:P52870"
FT                   /experiment="EXISTENCE:direct assay:GO:0005086 ARF
FT                   guanyl-nucleotide exchange factor activity [PMID:12750387]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005784 Sec61
FT                   translocon complex [PMID:7758110|PMID:8612571]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
FT                   reticulum membrane [PMID:31201345]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008320 protein
FT                   transmembrane transporter activity [PMID:9252322]"
FT                   /experiment="EXISTENCE:direct assay:GO:0015450
FT                   P-P-bond-hydrolysis-driven protein transmembrane
FT                   transporter activity [PMID:7758110]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031204
FT                   posttranslational protein targeting to membrane,
FT                   translocation [PMID:7758110]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006616
FT                   SRP-dependent cotranslational protein targeting to
FT                   membrane, translocation [PMID:19857245]"
FT                   /protein_id="DAA07748.1"
FT                   /translation="MSSPTPPGGQRTLQKRKQGSSQKVAASAPKKNTNSNNSILKIYSD
FT                   EATGLRVDPLVVLFLAVGFIFSVVALHVISKVAGKLF"
FT   gene            complement(333176..335188)
FT                   /gene="DOT6"
FT                   /gene_synonym="PBF2"
FT                   /locus_tag="YER088C"
FT   mRNA            complement(333176..335188)
FT                   /gene="DOT6"
FT                   /gene_synonym="PBF2"
FT                   /locus_tag="YER088C"
FT                   /product="Dot6p"
FT   CDS_pept        complement(333176..335188)
FT                   /codon_start=1
FT                   /gene="DOT6"
FT                   /gene_synonym="PBF2"
FT                   /locus_tag="YER088C"
FT                   /product="Dot6p"
FT                   /note="Protein involved in rRNA and ribosome biogenesis;
FT                   activated in stochastic pulses of nuclear localization;
FT                   binds polymerase A and C motif; subunit of the RPD3L
FT                   histone deacetylase complex; has chromatin specific SANT
FT                   domain; involved in telomeric gene silencing and
FT                   filamentation; relative distribution to the nucleus
FT                   increases upon DNA replication stress"
FT                   /db_xref="GOA:P40059"
FT                   /db_xref="InterPro:IPR001005"
FT                   /db_xref="InterPro:IPR009057"
FT                   /db_xref="InterPro:IPR017930"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40059"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043565
FT                   sequence-specific DNA binding [PMID:19158363]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070210
FT                   Rpd3L-Expanded complex [PMID:19040720]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000183
FT                   chromatin silencing at rDNA [PMID:9755194]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006348
FT                   chromatin silencing at telomere [PMID:9755194]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006357
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:19158363]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0061587 transfer
FT                   RNA gene-mediated silencing [PMID:23707796]"
FT                   /protein_id="DAA07749.1"
FT                   /translation="MSISTSLNSASIHLSSMDTHPQLHSLTRQPHSSSTAMSKNEAQES
FT                   SPSLPASSSSSTSASASASSKNSSKNPSSWDPQDDLLLRHLKEVKKMGWKDISQYFPNR
FT                   TPNACQFRWRRLKSGNLKSNKTALIDINTYTGPLKITHGDETANAQQKPSKKVEENVLT
FT                   EDTAEFTTTSSIPIPSRKTSLPSFHASMSFSQSPSNVTPTTIVSNAASSMPFAPPTLPA
FT                   ALPHHPHQHLHHHPHHKTLKPRSNSHSFTNSLNQDPIVRSNDEEKYGFIPKVFVRSRRS
FT                   SFAYPQQVAITTTPSSPNSSHVLLSSKSRRGSLANWSRRSSFNVSSNNTSRRSSMILAP
FT                   NSVSNIFNVNNSGSNTASTSNTNSRRESVIKKEFQQRLNNLSNSGGPTSNNGPIFPNSY
FT                   TFMDLPHSSSVSSSSTLHKSKRGSFSGHSMKSSCNPTNLWSKDEDALLMENKKRNLSVM
FT                   ELSILLPQRTEVEIQWRLNALSSDADMLSPTHSPQKTLSKKTCPRMFKSGSTTDDDKGS
FT                   DKEDVMGDGSNDDDEDNVDPLHRAKQSSNKTVFSSSSSNISSKDVSPDPIFSPDPADDS
FT                   SNTSDAGSRCTITSDTSSSAATMNRTPNSKNPQDIALLNNFRSEAITPRPKPSSTTTSI
FT                   TTETTNNMINHSSSTTTTTNNSPLPSINTIFKDML"
FT   gene            complement(335946..337340)
FT                   /gene="PTC2"
FT                   /locus_tag="YER089C"
FT   mRNA            complement(335946..337340)
FT                   /gene="PTC2"
FT                   /locus_tag="YER089C"
FT                   /product="type 2C protein phosphatase PTC2"
FT   CDS_pept        complement(335946..337340)
FT                   /codon_start=1
FT                   /gene="PTC2"
FT                   /locus_tag="YER089C"
FT                   /product="type 2C protein phosphatase PTC2"
FT                   /EC_number="3.1.3.16"
FT                   /note="Type 2C protein phosphatase (PP2C); dephosphorylates
FT                   Hog1p to limit maximal osmostress induced kinase activity;
FT                   dephosphorylates Ire1p to downregulate the unfolded protein
FT                   response; dephosphorylates Cdc28p; inactivates the DNA
FT                   damage checkpoint; PTC2 has a paralog, PTC3, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P39966"
FT                   /db_xref="InterPro:IPR000222"
FT                   /db_xref="InterPro:IPR001932"
FT                   /db_xref="InterPro:IPR015655"
FT                   /db_xref="InterPro:IPR036457"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39966"
FT                   /experiment="EXISTENCE:direct assay:GO:0000188 inactivation
FT                   of MAPK activity [PMID:12477803]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004722 protein
FT                   serine/threonine phosphatase activity [PMID:10580002]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004724
FT                   magnesium-dependent protein serine/threonine phosphatase
FT                   activity [PMID:9528768]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:12477803|PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:12477803|PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006470 protein
FT                   dephosphorylation [PMID:10580002]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035970
FT                   peptidyl-threonine dephosphorylation [PMID:12477803]"
FT                   /experiment="EXISTENCE:direct assay:GO:1990439 MAP kinase
FT                   serine/threonine phosphatase activity [PMID:12477803]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000188
FT                   inactivation of MAPK activity [PMID:12477803]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000079
FT                   regulation of cyclin-dependent protein serine/threonine
FT                   kinase activity [PMID:10580002]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000188
FT                   inactivation of MAPK activity [PMID:12477803]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1900102 negative
FT                   regulation of endoplasmic reticulum unfolded protein
FT                   response [PMID:9528768]"
FT                   /experiment="EXISTENCE:physical interaction:GO:1900102
FT                   negative regulation of endoplasmic reticulum unfolded
FT                   protein response [PMID:9528768]"
FT                   /protein_id="DAA07750.1"
FT                   /translation="MGQILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPN
FT                   VLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTD
FT                   VKLLQDPVMKEDHSGCTATSILVSKSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTL
FT                   ASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPDILEHSLD
FT                   YDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEGTGIG
FT                   CDNMSIVVVALLKEGEDVAQWSDRMKSKAHRTSVRSFADKRRRVFSYYDFSKCNDEQVF
FT                   AITTKKPQDKFTRDHEAAVASVTAADNDDPMDIDDTDADTDAENLDPSSQSKSKTSGPI
FT                   DLASLEALLGATGGVKTDSNGNKVTYTLPQSALAQLLQTMGHDPASSHPENDSNTDHKA
FT                   GRSHLQ"
FT   gene            337949..339472
FT                   /gene="TRP2"
FT                   /locus_tag="YER090W"
FT   mRNA            337949..339472
FT                   /gene="TRP2"
FT                   /locus_tag="YER090W"
FT                   /product="anthranilate synthase TRP2"
FT   CDS_pept        337949..339472
FT                   /codon_start=1
FT                   /gene="TRP2"
FT                   /locus_tag="YER090W"
FT                   /product="anthranilate synthase TRP2"
FT                   /EC_number="4.1.3.27"
FT                   /note="Anthranilate synthase; catalyzes the initial step of
FT                   tryptophan biosynthesis, forms multifunctional
FT                   hetero-oligomeric anthranilate synthase:indole-3-glycerol
FT                   phosphate synthase enzyme complex with Trp3p"
FT                   /db_xref="GOA:P00899"
FT                   /db_xref="InterPro:IPR005256"
FT                   /db_xref="InterPro:IPR005801"
FT                   /db_xref="InterPro:IPR006805"
FT                   /db_xref="InterPro:IPR015890"
FT                   /db_xref="InterPro:IPR019999"
FT                   /db_xref="UniProtKB/Swiss-Prot:P00899"
FT                   /experiment="EXISTENCE:direct assay:GO:0004049 anthranilate
FT                   synthase activity [PMID:3881257]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0004049
FT                   anthranilate synthase activity [PMID:6323449]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000162
FT                   tryptophan biosynthetic process [PMID:8432699]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005950
FT                   anthranilate synthase complex [PMID:3881257]"
FT                   /protein_id="DAA07751.1"
FT                   /translation="MTASIKIQPDIDSLKQLQQQNDDSSINMYPVYAYLPSLDLTPHVA
FT                   YLKLAQLNNPDRKESFLLESAKTNNELDRYSFIGISPRKTIKTGPTEGIETDPLEILEK
FT                   EMSTFKVAENVPGLPKLSGGAIGYISYDCVRYFEPKTRRPLKDVLRLPEAYLMLCDTII
FT                   AFDNVFQRFQIIHNINTNETSLEEGYQAAAQIITDIVSKLTDDSSPIPYPEQPPIKLNQ
FT                   TFESNVGKEGYENHVSTLKKHIKKGDIIQGVPSQRVARPTSLHPFNIYRHLRTVNPSPY
FT                   LFYIDCLDFQIIGASPELLCKSDSKNRVITHPIAGTVKRGATTEEDDALADQLRGSLKD
FT                   RAEHVMLVDLARNDINRICDPLTTSVDKLLTIQKFSHVQHLVSQVSGVLRPEKTRFDAF
FT                   RSIFPAGTVSGAPKVRAMELIAELEGERRGVYAGAVGHWSYDGKTMDNCIALRTMVYKD
FT                   GIAYLQAGGGIVYDSDEYDEYVETMNKMMANHSTIVQAEELWADIVGSA"
FT   gene            complement(339864..342167)
FT                   /gene="MET6"
FT                   /locus_tag="YER091C"
FT   mRNA            complement(339864..342167)
FT                   /gene="MET6"
FT                   /locus_tag="YER091C"
FT                   /product="5-methyltetrahydropteroyltriglutamate-homocysteine
FT                   S-methyltransferase"
FT   CDS_pept        complement(339864..342167)
FT                   /codon_start=1
FT                   /gene="MET6"
FT                   /locus_tag="YER091C"
FT                   /product="5-methyltetrahydropteroyltriglutamate-homocysteine
FT                   S-methyltransferase"
FT                   /EC_number="2.1.1.14"
FT                   /note="Cobalamin-independent methionine synthase; involved
FT                   in methionine biosynthesis and regeneration; requires a
FT                   minimum of two glutamates on the methyltetrahydrofolate
FT                   substrate, similar to bacterial metE homologs"
FT                   /db_xref="GOA:P05694"
FT                   /db_xref="InterPro:IPR002629"
FT                   /db_xref="InterPro:IPR006276"
FT                   /db_xref="InterPro:IPR013215"
FT                   /db_xref="InterPro:IPR038071"
FT                   /db_xref="UniProtKB/Swiss-Prot:P05694"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:16622836]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003871
FT                   5-methyltetrahydropteroyltriglutamate-homocysteine
FT                   S-methyltransferase activity [PMID:3542720]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009086
FT                   methionine biosynthetic process [PMID:1101032]"
FT                   /protein_id="DAA07752.1"
FT                   /translation="MVQSAVLGFPRIGPNRELKKATEGYWNGKITVDELFKVGKDLRTQ
FT                   NWKLQKEAGVDIIPSNDFSFYDQVLDLSLLFNVIPDRYTKYDLSPIDTLFAMGRGLQRK
FT                   ATETEKAVDVTALEMVKWFDSNYHYVRPTFSKTTQFKLNGQKPVDEFLEAKELGIHTRP
FT                   VLLGPVSYLFLGKADKDSLDLEPLSLLEQLLPLYTEILSKLASAGATEVQIDEPVLVLD
FT                   LPANAQAAIKKAYTYFGEQSNLPKITLATYFGTVVPNLDAIKGLPVAALHVDFVRAPEQ
FT                   FDEVVAAIGNKQTLSVGIVDGRNIWKNDFKKSSAIVNKAIEKLGADRVVVATSSSLLHT
FT                   PVDLNNETKLDAEIKGFFSFATQKLDEVVVITKNVSGQDVAAALEANAKSVESRGKSKF
FT                   IHDAAVKARVASIDEKMSTRAAPFEQRLPEQQKVFNLPLFPTTTIGSFPQTKDIRINRN
FT                   KFNKGTISAEEYEKFINSEIEKVIRFQEEIGLDVLVHGEPERNDMVQYFGEQINGYAFT
FT                   VNGWVQSYGSRYVRPPIIVGDLSRPKAMSVKESVYAQSITSKPVKGMLTGPITCLRWSF
FT                   PRDDVDQKTQAMQLALALRDEVNDLEAAGIKVIQVDEPALREGLPLREGTERSAYYTWA
FT                   AEAFRVATSGVANKTQIHSHFCYSDLDPNHIKALDADVVSIEFSKKDDANYIAEFKNYP
FT                   NHIGLGLFDIHSPRIPSKDEFIAKISTILKSYPAEKFWVNPDCGLKTRGWEETRLSLTH
FT                   MVEAAKYFREQYKN"
FT   gene            342855..343232
FT                   /gene="IES5"
FT                   /locus_tag="YER092W"
FT   mRNA            342855..343232
FT                   /gene="IES5"
FT                   /locus_tag="YER092W"
FT                   /product="Ies5p"
FT   CDS_pept        342855..343232
FT                   /codon_start=1
FT                   /gene="IES5"
FT                   /locus_tag="YER092W"
FT                   /product="Ies5p"
FT                   /note="Non-essential INO80 chromatin remodeling complex
FT                   subunit; deletion affects telomere maintenance via
FT                   recombination"
FT                   /db_xref="GOA:P40060"
FT                   /db_xref="InterPro:IPR020366"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40060"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000722
FT                   telomere maintenance via recombination [PMID:23390378]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031011
FT                   Ino80 complex [PMID:24034245]"
FT                   /protein_id="DAA07753.1"
FT                   /translation="MPSKDPESVIDKEIRKISARNDELIKQDGTLKREYTTLLRKVSSV
FT                   ITVLNSIDDADTGSAETELPRLISQATVEKVPELKWYNDQISLITEKLEDDEDIEVPEE
FT                   LMDAYTLYKETPLLYNDTHTP"
FT   gene            complement(343320..347612)
FT                   /gene="TSC11"
FT                   /gene_synonym="AVO3"
FT                   /locus_tag="YER093C"
FT   mRNA            complement(343320..347612)
FT                   /gene="TSC11"
FT                   /gene_synonym="AVO3"
FT                   /locus_tag="YER093C"
FT                   /product="TORC2 complex subunit TSC11"
FT   CDS_pept        complement(343320..347612)
FT                   /codon_start=1
FT                   /gene="TSC11"
FT                   /gene_synonym="AVO3"
FT                   /locus_tag="YER093C"
FT                   /product="TORC2 complex subunit TSC11"
FT                   /note="Subunit of TORC2
FT                   (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p); TORC2 is a
FT                   membrane-associated complex that regulates actin
FT                   cytoskeletal dynamics during polarized growth and cell wall
FT                   integrity; involved in sphingolipid metabolism; contains a
FT                   RasGEFN domain"
FT                   /db_xref="GOA:P40061"
FT                   /db_xref="InterPro:IPR011989"
FT                   /db_xref="InterPro:IPR016024"
FT                   /db_xref="InterPro:IPR028267"
FT                   /db_xref="InterPro:IPR028268"
FT                   /db_xref="InterPro:IPR029451"
FT                   /db_xref="InterPro:IPR029452"
FT                   /db_xref="InterPro:IPR029453"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40061"
FT                   /experiment="EXISTENCE:curator inference:GO:0031929 TOR
FT                   signaling [PMID:12408816]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:26928762]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0031505
FT                   fungal-type cell wall organization [PMID:15809876]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030148
FT                   sphingolipid biosynthetic process [PMID:9804843]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030950
FT                   establishment or maintenance of actin cytoskeleton polarity
FT                   [PMID:15809876]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031505
FT                   fungal-type cell wall organization [PMID:15809876]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0001558
FT                   regulation of cell growth [PMID:12408816]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005515
FT                   protein binding [PMID:12631735]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0030950
FT                   establishment or maintenance of actin cytoskeleton polarity
FT                   [PMID:12408816]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031932
FT                   TORC2 complex [PMID:12408816]"
FT                   /protein_id="DAA07754.1"
FT                   /translation="MSIPHSAKQSSPLSSRRRSVTNTTPLLTPRHSRDNSSTQISSAKN
FT                   ITSSSPSTITNESSKRNKQNLVLSTSFISTKRLENSAPSPTSPLMARRTRSTMTKALLN
FT                   LKAEINNQYQELARLRKKKDDIEHLRDSTISDIYSGSYSTNHLQKHSMRIRANTQLREI
FT                   DNSIKRVEKHIFDLKQQFDKKRQRSLTTSSSIKADVGSIRNDDGQNNDSEELGDHDSLT
FT                   DQVTLDDEYLTTPTSGTERNSQQNLNRNSTVNSRNNENHSTLSIPDLDGSNKVNLTGDT
FT                   EKDLGDLENENQIFTSTTTEAATWLVSDYMQSFQEKNVNPDFIAQKANGLVTLLKEHSE
FT                   IRKDLVLTSFMSSIQNLLLNGNKLIAASAYRVCRYLINSSIFIDELLELRLDAFIIISL
FT                   AKDNSFQIEREQALKMVRRFIEYNNGVTQGIMQAIISCVEKPEDSLRHMALETLLELCF
FT                   VAPEMVKECRGMRVIEGFLQDYTSFSLASVILDTILQLMATHKTRQHFLEDFNVSVLTT
FT                   VFSDTNTKSNVNVEKMQNASTLISITLNSYNGFMLFSNNNFKPLKQLVSFFQIPICAQY
FT                   LIDIFLDVLKIKPLPYKPRGRHSHSFKPIPSQYYKECMSVNQRLALIVLILENSEFVPH
FT                   LLELLNEEDRDDHLVAKGRYLLTEYFNLRMNLVDKKYTSVSKPIYKENFTYVNETFQFK
FT                   KIAYKMNRNRNTIGMSGIDYAQNIKSFSKNIKENTLLREVDDFRFRRMVYDSKVLQTKD
FT                   FTRWNWNIINELLEGPLLNKKQLEELVKSTKFIRRLLVFYRPLRLRFSNVNKGAKLSQK
FT                   YVQVGCQFFKTLTATPEGMKILMDDTKIIPQLASLMFRAMEGNISGNIFNKNKLREKII
FT                   FGYFKFIGILTQSKNGVHILTRWNFFTVIYKMFQFESKLGLEFLLLTIPELDLKYSSHC
FT                   RVIIGKALVVANEKVRIEATKHIGDKLKELLSTKESDLKLKANKVKLQQFKMEMLTRQL
FT                   YDLSPSVVAVADQALYECIVAGNGSEELGTSFRMFLNQMVFIRSPILFELLSRPYGFQL
FT                   LNEINFVKEERDSWLSKKNIEYVHIVEEFLKKNESINAKSLTFQQKSRLPLHFYESLTK
FT                   TEDGILLLSQTGDLVTFMNVIKKYVNGNNMATVENAKEILDLKAALWCVGFIGSTELGI
FT                   GLLDNYSLVEDIIEVAYNASVTSVRFTAFYVLGLISMTREGCEILDEMGWNCCVSVQDE
FT                   PIGIALPNRLDRFLSYNEHKWSAFGEYSDEMIVFNKSDGDLIEKCLPIEFDLDKLLKEK
FT                   DTAENPLNEKIITNKYDNDITSQTITVSGENSSLFANEGLSSPYVTQYRNDDDSIESKV
FT                   LHIVSQLGNHILSNHAVKEITEINNKYGPRLFENEKMFFKVFNMMSKYRFKPHVRKFLC
FT                   GLFINNRALENVIRHDNKRDKRPANFTR"
FT   gene            complement(347912..348400)
FT                   /gene="AIM11"
FT                   /gene_synonym="GEP8"
FT                   /locus_tag="YER093C-A"
FT   mRNA            complement(join(347912..348201,348277..348400))
FT                   /gene="AIM11"
FT                   /gene_synonym="GEP8"
FT                   /locus_tag="YER093C-A"
FT                   /product="Aim11p"
FT   CDS_pept        complement(join(347912..348201,348277..348400))
FT                   /codon_start=1
FT                   /gene="AIM11"
FT                   /gene_synonym="GEP8"
FT                   /locus_tag="YER093C-A"
FT                   /product="Aim11p"
FT                   /note="hypothetical protein; null mutant is viable but
FT                   shows increased loss of mitochondrial genome and synthetic
FT                   interaction with prohibitin (phb1); contains an intron;
FT                   SWAT-GFP and mCherry fusion proteins localize to the
FT                   mitochondria; YER093C-A has a paralog, YBL059W, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P87275"
FT                   /db_xref="InterPro:IPR038814"
FT                   /db_xref="UniProtKB/Swiss-Prot:P87275"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:26928762]"
FT                   /protein_id="DAA07755.1"
FT                   /translation="MIEEKKELKKRRVLQMARFYGAAAFTLITMRLISRAIKVRKYVPS
FT                   IFQQNYKLPPFSQRNEAMSALTYASAASIGTFSTLIFGFCWALDISTAREFVFKTREFM
FT                   SLPQALETDTSMDEETSKLTKQLQDLLSSENNK"
FT   gene            complement(348729..349346)
FT                   /gene="PUP3"
FT                   /gene_synonym="SCS32"
FT                   /locus_tag="YER094C"
FT   mRNA            complement(348729..349346)
FT                   /gene="PUP3"
FT                   /gene_synonym="SCS32"
FT                   /locus_tag="YER094C"
FT                   /product="proteasome core particle subunit beta 3"
FT   CDS_pept        complement(348729..349346)
FT                   /codon_start=1
FT                   /gene="PUP3"
FT                   /gene_synonym="SCS32"
FT                   /locus_tag="YER094C"
FT                   /product="proteasome core particle subunit beta 3"
FT                   /EC_number="3.4.25.1"
FT                   /note="Beta 3 subunit of the 20S proteasome; involved in
FT                   ubiquitin-dependent catabolism; human homolog is subunit
FT                   C10"
FT                   /db_xref="GOA:P25451"
FT                   /db_xref="InterPro:IPR001353"
FT                   /db_xref="InterPro:IPR016050"
FT                   /db_xref="InterPro:IPR023333"
FT                   /db_xref="InterPro:IPR029055"
FT                   /db_xref="InterPro:IPR033811"
FT                   /db_xref="PDB:1FNT"
FT                   /db_xref="PDB:1G0U"
FT                   /db_xref="PDB:1G65"
FT                   /db_xref="PDB:1JD2"
FT                   /db_xref="PDB:1RYP"
FT                   /db_xref="PDB:1Z7Q"
FT                   /db_xref="PDB:2F16"
FT                   /db_xref="PDB:2FAK"
FT                   /db_xref="PDB:2GPL"
FT                   /db_xref="PDB:2ZCY"
FT                   /db_xref="PDB:3BDM"
FT                   /db_xref="PDB:3D29"
FT                   /db_xref="PDB:3DY3"
FT                   /db_xref="PDB:3DY4"
FT                   /db_xref="PDB:3E47"
FT                   /db_xref="PDB:3GPJ"
FT                   /db_xref="PDB:3GPT"
FT                   /db_xref="PDB:3GPW"
FT                   /db_xref="PDB:3HYE"
FT                   /db_xref="PDB:3JCO"
FT                   /db_xref="PDB:3JCP"
FT                   /db_xref="PDB:3MG0"
FT                   /db_xref="PDB:3MG4"
FT                   /db_xref="PDB:3MG6"
FT                   /db_xref="PDB:3MG7"
FT                   /db_xref="PDB:3MG8"
FT                   /db_xref="PDB:3NZJ"
FT                   /db_xref="PDB:3NZW"
FT                   /db_xref="PDB:3NZX"
FT                   /db_xref="PDB:3OEU"
FT                   /db_xref="PDB:3OEV"
FT                   /db_xref="PDB:3OKJ"
FT                   /db_xref="PDB:3SDI"
FT                   /db_xref="PDB:3SDK"
FT                   /db_xref="PDB:3SHJ"
FT                   /db_xref="PDB:3TDD"
FT                   /db_xref="PDB:3UN4"
FT                   /db_xref="PDB:3UN8"
FT                   /db_xref="PDB:3WXR"
FT                   /db_xref="PDB:4CR2"
FT                   /db_xref="PDB:4CR3"
FT                   /db_xref="PDB:4CR4"
FT                   /db_xref="PDB:4EU2"
FT                   /db_xref="PDB:4FZC"
FT                   /db_xref="PDB:4FZG"
FT                   /db_xref="PDB:4G4S"
FT                   /db_xref="PDB:4GK7"
FT                   /db_xref="PDB:4HNP"
FT                   /db_xref="PDB:4HRC"
FT                   /db_xref="PDB:4HRD"
FT                   /db_xref="PDB:4INR"
FT                   /db_xref="PDB:4INT"
FT                   /db_xref="PDB:4INU"
FT                   /db_xref="PDB:4J70"
FT                   /db_xref="PDB:4JSQ"
FT                   /db_xref="PDB:4JSU"
FT                   /db_xref="PDB:4JT0"
FT                   /db_xref="PDB:4LQI"
FT                   /db_xref="PDB:4LTC"
FT                   /db_xref="PDB:4NNN"
FT                   /db_xref="PDB:4NNW"
FT                   /db_xref="PDB:4NO1"
FT                   /db_xref="PDB:4NO6"
FT                   /db_xref="PDB:4NO8"
FT                   /db_xref="PDB:4NO9"
FT                   /db_xref="PDB:4Q1S"
FT                   /db_xref="PDB:4QBY"
FT                   /db_xref="PDB:4QLQ"
FT                   /db_xref="PDB:4QLS"
FT                   /db_xref="PDB:4QLT"
FT                   /db_xref="PDB:4QLU"
FT                   /db_xref="PDB:4QLV"
FT                   /db_xref="PDB:4QUX"
FT                   /db_xref="PDB:4QUY"
FT                   /db_xref="PDB:4QV0"
FT                   /db_xref="PDB:4QV1"
FT                   /db_xref="PDB:4QV3"
FT                   /db_xref="PDB:4QV4"
FT                   /db_xref="PDB:4QV5"
FT                   /db_xref="PDB:4QV6"
FT                   /db_xref="PDB:4QV7"
FT                   /db_xref="PDB:4QV8"
FT                   /db_xref="PDB:4QV9"
FT                   /db_xref="PDB:4QVL"
FT                   /db_xref="PDB:4QVM"
FT                   /db_xref="PDB:4QVN"
FT                   /db_xref="PDB:4QVP"
FT                   /db_xref="PDB:4QVQ"
FT                   /db_xref="PDB:4QVV"
FT                   /db_xref="PDB:4QVW"
FT                   /db_xref="PDB:4QVY"
FT                   /db_xref="PDB:4QW0"
FT                   /db_xref="PDB:4QW1"
FT                   /db_xref="PDB:4QW3"
FT                   /db_xref="PDB:4QW4"
FT                   /db_xref="PDB:4QW5"
FT                   /db_xref="PDB:4QW6"
FT                   /db_xref="PDB:4QW7"
FT                   /db_xref="PDB:4QWF"
FT                   /db_xref="PDB:4QWG"
FT                   /db_xref="PDB:4QWI"
FT                   /db_xref="PDB:4QWJ"
FT                   /db_xref="PDB:4QWK"
FT                   /db_xref="PDB:4QWL"
FT                   /db_xref="PDB:4QWR"
FT                   /db_xref="PDB:4QWS"
FT                   /db_xref="PDB:4QWU"
FT                   /db_xref="PDB:4QWX"
FT                   /db_xref="PDB:4QXJ"
FT                   /db_xref="PDB:4QZ0"
FT                   /db_xref="PDB:4QZ1"
FT                   /db_xref="PDB:4QZ2"
FT                   /db_xref="PDB:4QZ3"
FT                   /db_xref="PDB:4QZ4"
FT                   /db_xref="PDB:4QZ5"
FT                   /db_xref="PDB:4QZ6"
FT                   /db_xref="PDB:4QZ7"
FT                   /db_xref="PDB:4QZW"
FT                   /db_xref="PDB:4QZX"
FT                   /db_xref="PDB:4QZZ"
FT                   /db_xref="PDB:4R00"
FT                   /db_xref="PDB:4R02"
FT                   /db_xref="PDB:4R17"
FT                   /db_xref="PDB:4R18"
FT                   /db_xref="PDB:4RUR"
FT                   /db_xref="PDB:4V7O"
FT                   /db_xref="PDB:4X6Z"
FT                   /db_xref="PDB:4Y69"
FT                   /db_xref="PDB:4Y6A"
FT                   /db_xref="PDB:4Y6V"
FT                   /db_xref="PDB:4Y6Z"
FT                   /db_xref="PDB:4Y70"
FT                   /db_xref="PDB:4Y74"
FT                   /db_xref="PDB:4Y75"
FT                   /db_xref="PDB:4Y77"
FT                   /db_xref="PDB:4Y78"
FT                   /db_xref="PDB:4Y7W"
FT                   /db_xref="PDB:4Y7X"
FT                   /db_xref="PDB:4Y7Y"
FT                   /db_xref="PDB:4Y80"
FT                   /db_xref="PDB:4Y81"
FT                   /db_xref="PDB:4Y82"
FT                   /db_xref="PDB:4Y84"
FT                   /db_xref="PDB:4Y8G"
FT                   /db_xref="PDB:4Y8H"
FT                   /db_xref="PDB:4Y8I"
FT                   /db_xref="PDB:4Y8J"
FT                   /db_xref="PDB:4Y8K"
FT                   /db_xref="PDB:4Y8L"
FT                   /db_xref="PDB:4Y8M"
FT                   /db_xref="PDB:4Y8N"
FT                   /db_xref="PDB:4Y8O"
FT                   /db_xref="PDB:4Y8P"
FT                   /db_xref="PDB:4Y8Q"
FT                   /db_xref="PDB:4Y8R"
FT                   /db_xref="PDB:4Y8S"
FT                   /db_xref="PDB:4Y8T"
FT                   /db_xref="PDB:4Y8U"
FT                   /db_xref="PDB:4Y9Y"
FT                   /db_xref="PDB:4Y9Z"
FT                   /db_xref="PDB:4YA0"
FT                   /db_xref="PDB:4YA1"
FT                   /db_xref="PDB:4YA2"
FT                   /db_xref="PDB:4YA3"
FT                   /db_xref="PDB:4YA4"
FT                   /db_xref="PDB:4YA5"
FT                   /db_xref="PDB:4YA7"
FT                   /db_xref="PDB:4YA9"
FT                   /db_xref="PDB:4Z1L"
FT                   /db_xref="PDB:5A5B"
FT                   /db_xref="PDB:5AHJ"
FT                   /db_xref="PDB:5BOU"
FT                   /db_xref="PDB:5BXL"
FT                   /db_xref="PDB:5BXN"
FT                   /db_xref="PDB:5CGF"
FT                   /db_xref="PDB:5CGG"
FT                   /db_xref="PDB:5CGH"
FT                   /db_xref="PDB:5CGI"
FT                   /db_xref="PDB:5CZ4"
FT                   /db_xref="PDB:5CZ5"
FT                   /db_xref="PDB:5CZ6"
FT                   /db_xref="PDB:5CZ7"
FT                   /db_xref="PDB:5CZ8"
FT                   /db_xref="PDB:5CZ9"
FT                   /db_xref="PDB:5CZA"
FT                   /db_xref="PDB:5D0S"
FT                   /db_xref="PDB:5D0T"
FT                   /db_xref="PDB:5D0V"
FT                   /db_xref="PDB:5D0W"
FT                   /db_xref="PDB:5D0X"
FT                   /db_xref="PDB:5D0Z"
FT                   /db_xref="PDB:5DKI"
FT                   /db_xref="PDB:5DKJ"
FT                   /db_xref="PDB:5FG7"
FT                   /db_xref="PDB:5FG9"
FT                   /db_xref="PDB:5FGA"
FT                   /db_xref="PDB:5FGD"
FT                   /db_xref="PDB:5FGE"
FT                   /db_xref="PDB:5FGF"
FT                   /db_xref="PDB:5FGG"
FT                   /db_xref="PDB:5FGH"
FT                   /db_xref="PDB:5FGI"
FT                   /db_xref="PDB:5FHS"
FT                   /db_xref="PDB:5JHR"
FT                   /db_xref="PDB:5JHS"
FT                   /db_xref="PDB:5L52"
FT                   /db_xref="PDB:5L54"
FT                   /db_xref="PDB:5L55"
FT                   /db_xref="PDB:5L5A"
FT                   /db_xref="PDB:5L5B"
FT                   /db_xref="PDB:5L5D"
FT                   /db_xref="PDB:5L5E"
FT                   /db_xref="PDB:5L5F"
FT                   /db_xref="PDB:5L5H"
FT                   /db_xref="PDB:5L5I"
FT                   /db_xref="PDB:5L5J"
FT                   /db_xref="PDB:5L5O"
FT                   /db_xref="PDB:5L5P"
FT                   /db_xref="PDB:5L5Q"
FT                   /db_xref="PDB:5L5R"
FT                   /db_xref="PDB:5L5S"
FT                   /db_xref="PDB:5L5T"
FT                   /db_xref="PDB:5L5U"
FT                   /db_xref="PDB:5L5V"
FT                   /db_xref="PDB:5L5W"
FT                   /db_xref="PDB:5L5X"
FT                   /db_xref="PDB:5L5Y"
FT                   /db_xref="PDB:5L5Z"
FT                   /db_xref="PDB:5L60"
FT                   /db_xref="PDB:5L61"
FT                   /db_xref="PDB:5L62"
FT                   /db_xref="PDB:5L63"
FT                   /db_xref="PDB:5L64"
FT                   /db_xref="PDB:5L65"
FT                   /db_xref="PDB:5L66"
FT                   /db_xref="PDB:5L67"
FT                   /db_xref="PDB:5L68"
FT                   /db_xref="PDB:5L69"
FT                   /db_xref="PDB:5L6A"
FT                   /db_xref="PDB:5L6B"
FT                   /db_xref="PDB:5L6C"
FT                   /db_xref="PDB:5LAI"
FT                   /db_xref="PDB:5LAJ"
FT                   /db_xref="PDB:5LTT"
FT                   /db_xref="PDB:5M2B"
FT                   /db_xref="PDB:5MP9"
FT                   /db_xref="PDB:5MPA"
FT                   /db_xref="PDB:5MPB"
FT                   /db_xref="PDB:5MPC"
FT                   /db_xref="PDB:5NIF"
FT                   /db_xref="PDB:5WVI"
FT                   /db_xref="PDB:5WVK"
FT                   /db_xref="PDB:6EF3"
FT                   /db_xref="PDB:6FVT"
FT                   /db_xref="PDB:6FVU"
FT                   /db_xref="PDB:6FVV"
FT                   /db_xref="PDB:6FVW"
FT                   /db_xref="PDB:6FVX"
FT                   /db_xref="PDB:6FVY"
FT                   /db_xref="PDB:6G7F"
FT                   /db_xref="PDB:6G8M"
FT                   /db_xref="PDB:6G8N"
FT                   /db_xref="PDB:6GOP"
FT                   /db_xref="PDB:6H39"
FT                   /db_xref="PDB:6HTB"
FT                   /db_xref="PDB:6HTC"
FT                   /db_xref="PDB:6HTD"
FT                   /db_xref="PDB:6HTP"
FT                   /db_xref="PDB:6HTR"
FT                   /db_xref="PDB:6HUB"
FT                   /db_xref="PDB:6HUC"
FT                   /db_xref="PDB:6HUQ"
FT                   /db_xref="PDB:6HUU"
FT                   /db_xref="PDB:6HUV"
FT                   /db_xref="PDB:6HV3"
FT                   /db_xref="PDB:6HV4"
FT                   /db_xref="PDB:6HV5"
FT                   /db_xref="PDB:6HV7"
FT                   /db_xref="PDB:6HVA"
FT                   /db_xref="PDB:6HVR"
FT                   /db_xref="PDB:6HVS"
FT                   /db_xref="PDB:6HVT"
FT                   /db_xref="PDB:6HVU"
FT                   /db_xref="PDB:6HVV"
FT                   /db_xref="PDB:6HVW"
FT                   /db_xref="PDB:6HVX"
FT                   /db_xref="PDB:6HVY"
FT                   /db_xref="PDB:6HW0"
FT                   /db_xref="PDB:6HW3"
FT                   /db_xref="PDB:6HW4"
FT                   /db_xref="PDB:6HW5"
FT                   /db_xref="PDB:6HW6"
FT                   /db_xref="PDB:6HW7"
FT                   /db_xref="PDB:6HW8"
FT                   /db_xref="PDB:6HW9"
FT                   /db_xref="PDB:6HWA"
FT                   /db_xref="PDB:6HWB"
FT                   /db_xref="PDB:6HWC"
FT                   /db_xref="PDB:6HWD"
FT                   /db_xref="PDB:6HWE"
FT                   /db_xref="PDB:6HWF"
FT                   /db_xref="PDB:6J2C"
FT                   /db_xref="PDB:6J2N"
FT                   /db_xref="PDB:6J2Q"
FT                   /db_xref="PDB:6J2X"
FT                   /db_xref="PDB:6J30"
FT                   /db_xref="UniProtKB/Swiss-Prot:P25451"
FT                   /experiment="EXISTENCE:curator inference:GO:0005634 nucleus
FT                   [PMID:9087403]"
FT                   /experiment="EXISTENCE:curator inference:GO:0005789
FT                   endoplasmic reticulum membrane [PMID:9087403]"
FT                   /experiment="EXISTENCE:curator inference:GO:0034515
FT                   proteasome storage granule [PMID:9087403]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal
FT                   ubiquitin-independent protein catabolic process
FT                   [PMID:19162040]"
FT                   /experiment="EXISTENCE:direct assay:GO:0019774 proteasome
FT                   core complex, beta-subunit complex [PMID:9087403]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043161
FT                   proteasome-mediated ubiquitin-dependent protein catabolic
FT                   process [PMID:11545745|PMID:19029916]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0061133
FT                   endopeptidase activator activity [PMID:9207060]"
FT                   /protein_id="DAA07756.1"
FT                   /translation="MSDPSSINGGIVVAMTGKDCVAIACDLRLGSQSLGVSNKFEKIFH
FT                   YGHVFLGITGLATDVTTLNEMFRYKTNLYKLKEERAIEPETFTQLVSSSLYERRFGPYF
FT                   VGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEPEDL
FT                   FETISQALLNAADRDALSGWGAVVYIIKKDEVVKRYLKMRQD"
FT   gene            349980..351182
FT                   /gene="RAD51"
FT                   /gene_synonym="MUT5"
FT                   /locus_tag="YER095W"
FT   mRNA            349980..351182
FT                   /gene="RAD51"
FT                   /gene_synonym="MUT5"
FT                   /locus_tag="YER095W"
FT                   /product="recombinase RAD51"
FT   CDS_pept        349980..351182
FT                   /codon_start=1
FT                   /gene="RAD51"
FT                   /gene_synonym="MUT5"
FT                   /locus_tag="YER095W"
FT                   /product="recombinase RAD51"
FT                   /note="Strand exchange protein; forms a helical filament
FT                   with DNA that searches for homology; involved in the
FT                   recombinational repair of double-strand breaks in DNA
FT                   during vegetative growth and meiosis; homolog of Dmc1p and
FT                   bacterial RecA protein"
FT                   /db_xref="GOA:P25454"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="InterPro:IPR010995"
FT                   /db_xref="InterPro:IPR011941"
FT                   /db_xref="InterPro:IPR013632"
FT                   /db_xref="InterPro:IPR016467"
FT                   /db_xref="InterPro:IPR020587"
FT                   /db_xref="InterPro:IPR020588"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR033925"
FT                   /db_xref="PDB:1SZP"
FT                   /db_xref="PDB:3LDA"
FT                   /db_xref="UniProtKB/Swiss-Prot:P25454"
FT                   /experiment="EXISTENCE:direct assay:GO:0000150 recombinase
FT                   activity [PMID:8066464]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000228 nuclear
FT                   chromosome [PMID:11459983]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000794 condensed
FT                   nuclear chromosome [PMID:9427283]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
FT                   [PMID:26540255]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003697
FT                   single-stranded DNA binding [PMID:20371520]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005759
FT                   mitochondrial matrix [PMID:26540255]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006310 DNA
FT                   recombination [PMID:22955832]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008094
FT                   DNA-dependent ATPase activity [PMID:8066464]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex
FT                   formation [PMID:10506208]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042148 strand
FT                   invasion [PMID:8066464|PMID:9271413]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000709 meiotic
FT                   joint molecule formation [PMID:1581961]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere
FT                   maintenance via recombination [PMID:25822194]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007131
FT                   reciprocal meiotic recombination [PMID:16581767]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043504
FT                   mitochondrial DNA repair [PMID:26540255]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005515
FT                   protein binding [PMID:31142613]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006289
FT                   nucleotide-excision repair [PMID:7026973]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006302
FT                   double-strand break repair [PMID:7026973]"
FT                   /protein_id="DAA07757.1"
FT                   /translation="MSQVQEQHISESQLQYGNGSLMSTVPADLSQSVVDGNGNGSSEDI
FT                   EATNGSGDGGGLQEQAEAQGEMEDEAYDEAALGSFVPIEKLQVNGITMADVKKLRESGL
FT                   HTAEAVAYAPRKDLLEIKGISEAKADKLLNEAARLVPMGFVTAADFHMRRSELICLTTG
FT                   SKNLDTLLGGGVETGSITELFGEFRTGKSQLCHTLAVTCQIPLDIGGGEGKCLYIDTEG
FT                   TFRPVRLVSIAQRFGLDPDDALNNVAYARAYNADHQLRLLDAAAQMMSESRFSLIVVDS
FT                   VMALYRTDFSGRGELSARQMHLAKFMRALQRLADQFGVAVVVTNQVVAQVDGGMAFNPD
FT                   PKKPIGGNIMAHSSTTRLGFKKGKGCQRLCKVVDSPCLPEAECVFAIYEDGVGDPREED
FT                   E"
FT   gene            351698..353236
FT                   /gene="SHC1"
FT                   /locus_tag="YER096W"
FT   mRNA            351698..353236
FT                   /gene="SHC1"
FT                   /locus_tag="YER096W"
FT                   /product="Shc1p"
FT   CDS_pept        351698..353236
FT                   /codon_start=1
FT                   /gene="SHC1"
FT                   /locus_tag="YER096W"
FT                   /product="Shc1p"
FT                   /note="Sporulation-specific activator of Chs3p (chitin
FT                   synthase III); required for the synthesis of the chitosan
FT                   layer of ascospores; transcriptionally induced at alkaline
FT                   pH; SHC1 has a paralog, SKT5, that arose from the whole
FT                   genome duplication"
FT                   /db_xref="GOA:P39000"
FT                   /db_xref="InterPro:IPR006597"
FT                   /db_xref="InterPro:IPR011990"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39000"
FT                   /experiment="EXISTENCE:direct assay:GO:0005628 prospore
FT                   membrane [PMID:15755916]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030437 ascospore
FT                   formation [PMID:11918806]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006031
FT                   chitin biosynthetic process [PMID:11918806]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0008047
FT                   enzyme activator activity [PMID:11918806]"
FT                   /protein_id="DAA07758.1"
FT                   /translation="MSMTICSNTPGAYPEIGAYNEVDKQLESSGFSSDSSLILNKPEVR
FT                   QYWSSVSSHISRSGDVFTNDKEKISSSIGEDAMDIDASPSLIEKYNSFPTRKILPEQDE
FT                   FENDVEDDASSSLKEKSQGSCEIEIASEISSEILNGTSADGNSEFHDFAEPPPSQNESV
FT                   ALSFSQSNDLDFLNNPSGSGSSNDINRSTSSISLPRHVSLDFNVYNSLCLTNEVTASES
FT                   HNVAKFHLGKKNKKSLLPRWKTIEMYGEVVKKTQDIYSNFQYAQYILRVGLDTEKLHEL
FT                   VKELEDESNSFSVDSLKEYLVNDAKVILKKLSAVGYPDAQYLLGDAYSSGVFGKIKNRR
FT                   AFLLFSAAAKRMHIESVYRTAICYECGLGVTRNAPKAVNFLTFAATKNHPAAMYKLGVY
FT                   SYHGLMGLPDDILTKMDGYRWLRRATSMASSFVCGAPFELANIYMTGYKDLIISDPDYA
FT                   MALYEKAAALGHTESARILEDARRSGGFVSRGHPPSAQKYHKTSHEAVAAKKLI"
FT   repeat_region   353399..353735
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   rep_origin      353578..353636
FT                   /note="ARS516; Autonomously Replicating Sequence"
FT   repeat_region   354136..354850
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   repeat_region   complement(354360..354730)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty4 LTR"
FT   repeat_region   complement(354851..354917)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty3 LTR"
FT   gene            354934..355005
FT                   /locus_tag="tE(UUC)E2"
FT   tRNA            354934..355005
FT                   /locus_tag="tE(UUC)E2"
FT                   /product="tRNA-Glu"
FT                   /note="tE(UUC)E2; Glutamate tRNA (tRNA-Glu), predicted by
FT                   tRNAscan-SE analysis; thiolation of uridine at wobble
FT                   position (34) requires Ncs6p"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   gene            355466..357730
FT                   /gene="UBP9"
FT                   /locus_tag="YER098W"
FT   mRNA            355466..357730
FT                   /gene="UBP9"
FT                   /locus_tag="YER098W"
FT                   /product="putative ubiquitin-specific protease UBP9"
FT   CDS_pept        355466..357730
FT                   /codon_start=1
FT                   /gene="UBP9"
FT                   /locus_tag="YER098W"
FT                   /product="putative ubiquitin-specific protease UBP9"
FT                   /EC_number="3.4.19.12"
FT                   /note="Ubiquitin-specific protease that cleaves
FT                   ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that
FT                   arose from the whole genome duplication"
FT                   /db_xref="GOA:P39967"
FT                   /db_xref="InterPro:IPR001394"
FT                   /db_xref="InterPro:IPR018200"
FT                   /db_xref="InterPro:IPR028889"
FT                   /db_xref="InterPro:IPR038765"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39967"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /protein_id="DAA07759.1"
FT                   /translation="MIKRWLSVNRKKSHPEKNTQGNDEINRKATSLKKTKGSGDPSIAK
FT                   SPSAKSSTSSIPSNLASHERRSKFSSQTDNLAGNKHYHEHYHNMASTSDEREYDSSTTY
FT                   EDRAFDTESSILFTTITDLMPYGDGSNKVFGYENFGNTCYCNSVLQCLYNIPEFRCNVL
FT                   RYPERVAAVNRIRKSDLKGSKIRVFTNESFETSTNSGNSNTGYQSNDNEDAHNHHHLQQ
FT                   SDQDNSSSSTQEKQNNFERKRNSFMGFGKDKSNYKDSAKKDDNNEMERPQPVHTVVMAS
FT                   DTLTEKLHEGCKKIIVGRPLLKQSDSLSKASTTDCQANSHCQCDSQGSRITSVDDDVLV
FT                   NPESCNDAVNNSNNNKENTFPTSEQRKKAALIRGPVLNVDHLLYPTEEATLYNGLKDIF
FT                   ESITENLSLTGIVSPTEFVKILKKENVLFNTMMQQDAHEFLNFLLNDFSEYIQRNNPRM
FT                   RFGPQKTDNSNDNFITDLFKGTLTNRIKCLTCDNITSRDEPFLDFPIEVQGDEETDIQK
FT                   MLKSYHQREMLNGVNKFYCNKCYGLQEAERMVGLKQLPHILSLHLKRFKYSEEQKSNIK
FT                   LFNKILYPLTLDVSSTFNTSVYKKYELSGVVIHMGSGPQHGHYVCICRNEKFGWLLYDD
FT                   ETVESIKEETVLQFTGHPGDQTTAYVLFYKETQADKTENQNENIDTSSQDQMQTDNNIE
FT                   QLIKCDDWLRDRKLRAAANIERKKTLGNIPEVKTAETKTPLNDKKRNKQKRKSRILSFI
FT                   K"
FT   gene            complement(358105..359061)
FT                   /gene="PRS2"
FT                   /locus_tag="YER099C"
FT   mRNA            complement(358105..359061)
FT                   /gene="PRS2"
FT                   /locus_tag="YER099C"
FT                   /product="ribose phosphate diphosphokinase subunit PRS2"
FT   CDS_pept        complement(358105..359061)
FT                   /codon_start=1
FT                   /gene="PRS2"
FT                   /locus_tag="YER099C"
FT                   /product="ribose phosphate diphosphokinase subunit PRS2"
FT                   /EC_number="2.7.6.1"
FT                   /note="5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase;
FT                   synthesizes PRPP, which is required for nucleotide,
FT                   histidine, and tryptophan biosynthesis; one of five related
FT                   enzymes, which are active as heteromultimeric complexes;
FT                   PRS2 has a paralog, PRS4, that arose from the whole genome
FT                   duplication"
FT                   /db_xref="GOA:P38620"
FT                   /db_xref="InterPro:IPR000836"
FT                   /db_xref="InterPro:IPR000842"
FT                   /db_xref="InterPro:IPR005946"
FT                   /db_xref="InterPro:IPR029057"
FT                   /db_xref="InterPro:IPR029099"
FT                   /db_xref="UniProtKB/Swiss-Prot:P38620"
FT                   /experiment="EXISTENCE:direct assay:GO:0002189 ribose
FT                   phosphate diphosphokinase complex [PMID:15280369]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0004749
FT                   ribose phosphate diphosphokinase activity [PMID:15280369]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006015
FT                   5-phosphoribose 1-diphosphate biosynthetic process
FT                   [PMID:15280369]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006015
FT                   5-phosphoribose 1-diphosphate biosynthetic process
FT                   [PMID:10212224]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031505
FT                   fungal-type cell wall organization [PMID:15470112]"
FT                   /protein_id="DAA07760.1"
FT                   /translation="MSTNSIKLLAGNSHPGLAELISQRLGVPLSKVGVYQYSNKETSVT
FT                   IGESIRDEDVYIIQTGYGEHEINDFLMELLILIHACKTASVRRITAVIPNFPYARQDKK
FT                   DKSRAPITAKLIANLLETAGCDHVITMDLHASQIQGFFHIPVDNLYGEPSVLNYIRTKT
FT                   DFNNAILVSPDAGGAKRVASLADKLDMNFALIHKERQKANEVSRMLLVGDVAGKSCLLI
FT                   DDMADTCGTLVKACDTLMDHGAKEVIAIVTHGIFSGSAREKLINSRLSRIVCTNTVPVD
FT                   LDLDIVDQVDISPTIAEAIRRLHNGESVSYLFTHAPV"
FT   gene            359562..360314
FT                   /gene="UBC6"
FT                   /gene_synonym="DOA2"
FT                   /locus_tag="YER100W"
FT   mRNA            359562..360314
FT                   /gene="UBC6"
FT                   /gene_synonym="DOA2"
FT                   /locus_tag="YER100W"
FT                   /product="E2 ubiquitin-conjugating protein UBC6"
FT   CDS_pept        359562..360314
FT                   /codon_start=1
FT                   /gene="UBC6"
FT                   /gene_synonym="DOA2"
FT                   /locus_tag="YER100W"
FT                   /product="E2 ubiquitin-conjugating protein UBC6"
FT                   /EC_number="2.3.2.23"
FT                   /note="Ubiquitin-conjugating enzyme involved in ERAD;
FT                   located at the cytosolic side of the ER membrane; tail
FT                   region contains a transmembrane segment at the C-terminus;
FT                   substrate of the ubiquitin-proteasome pathway;
FT                   ER-associated protein degradation is also known as ERAD"
FT                   /db_xref="GOA:P33296"
FT                   /db_xref="InterPro:IPR000608"
FT                   /db_xref="InterPro:IPR016135"
FT                   /db_xref="UniProtKB/Swiss-Prot:P33296"
FT                   /experiment="EXISTENCE:direct assay:GO:0004842
FT                   ubiquitin-protein transferase activity [PMID:8396728]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic
FT                   reticulum membrane [PMID:8396728]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006513 protein
FT                   monoubiquitination [PMID:8396728]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0030433
FT                   ubiquitin-dependent ERAD pathway
FT                   [PMID:8396728|PMID:8641272|PMID:8781238]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein
FT                   polyubiquitination [PMID:19345192]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004842
FT                   ubiquitin-protein transferase activity
FT                   [PMID:18191224|PMID:8396728]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006513 protein
FT                   monoubiquitination [PMID:8396728]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030433
FT                   ubiquitin-dependent ERAD pathway
FT                   [PMID:18191224|PMID:8393731|PMID:8641272|PMID:8781238]"
FT                   /protein_id="DAA07761.1"
FT                   /translation="MATKQAHKRLTKEYKLMVENPPPYILARPNEDNILEWHYIITGPA
FT                   DTPYKGGQYHGTLTFPSDYPYKPPAIRMITPNGRFKPNTRLCLSMSDYHPDTWNPGWSV
FT                   STILNGLLSFMTSDEATTGSITTSDHQKKTLARNSISYNTFQNVRFKLIFPEVVQENVE
FT                   TLEKRKLDEGDAANTGDETEDPFTKAAKEKVISLEEILDPEDRIRAEQALRQSENNSKK
FT                   DGKEPNDSSSMVYIGIAIFLFLVGLFMK"
FT   gene            complement(360502..361794)
FT                   /gene="AST2"
FT                   /locus_tag="YER101C"
FT   mRNA            complement(360502..361794)
FT                   /gene="AST2"
FT                   /locus_tag="YER101C"
FT                   /product="Ast2p"
FT   CDS_pept        complement(360502..361794)
FT                   /codon_start=1
FT                   /gene="AST2"
FT                   /locus_tag="YER101C"
FT                   /product="Ast2p"
FT                   /note="Lipid raft associated protein; overexpression
FT                   restores Pma1p localization to lipid rafts which is
FT                   required for targeting of Pma1p to the plasma membrane;
FT                   sometimes classified in the medium-chain
FT                   dehydrogenase/reductases (MDRs) superfamily; AST2 has a
FT                   paralog, AST1, that arose from the whole genome
FT                   duplication"
FT                   /db_xref="GOA:P39945"
FT                   /db_xref="InterPro:IPR011032"
FT                   /db_xref="InterPro:IPR013154"
FT                   /db_xref="InterPro:IPR020843"
FT                   /db_xref="InterPro:IPR036291"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39945"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:11914276|PMID:14562095]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006612
FT                   protein targeting to membrane [PMID:7822420]"
FT                   /protein_id="DAA07762.1"
FT                   /translation="MAEKILENKDPKLEAMTVDHEVSAPKPIPVDEPTLTRVARPLRHV
FT                   RHIPVKSLVFHSKHGPITFSYENKIKLPISKNKLVVQVNYVGLNPVDMKIRNGYTKPIY
FT                   GEAGIGREYSGVITHVGDNLTNRWNVGDDVYGIYYHPKLAIGALQSSLLIDPRVDPILM
FT                   RPKNTLSPEKAAGSLFCLGTALNLLAQLKEKDQLNTESNVLINGGTSSVGMFAIQLLKR
FT                   YYKVSKKLVVVTSGNGAAVLSEHFPDLKDEIIFINYLSCRGKSSKPLRRMLDTGKVVDY
FT                   DDFNTLKETEDYTQGKFNVVLDFIGGYDILSHSSSLIHAKGAYITTVGDYVGNYKKDVF
FT                   DSWDNPSANARKMFGSMLWSYDYSHFYFDPNIKIIPKKNDWIHECGKLLNEGVVDCVVD
FT                   KVYSWKNFKEAFSYMATQRAQGKLIMKVEGF"
FT   gene            363100..363702
FT                   /gene="RPS8B"
FT                   /locus_tag="YER102W"
FT   mRNA            363100..363702
FT                   /gene="RPS8B"
FT                   /locus_tag="YER102W"
FT                   /product="ribosomal 40S subunit protein S8B"
FT   CDS_pept        363100..363702
FT                   /codon_start=1
FT                   /gene="RPS8B"
FT                   /locus_tag="YER102W"
FT                   /product="ribosomal 40S subunit protein S8B"
FT                   /note="Protein component of the small (40S) ribosomal
FT                   subunit; homologous to mammalian ribosomal protein S8, no
FT                   bacterial homolog; RPS8B has a paralog, RPS8A, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P0CX40"
FT                   /db_xref="InterPro:IPR001047"
FT                   /db_xref="InterPro:IPR018283"
FT                   /db_xref="InterPro:IPR022309"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CX40"
FT                   /experiment="EXISTENCE:curator inference:GO:0002181
FT                   cytoplasmic translation [PMID:18782943]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003735 structural
FT                   constituent of ribosome [PMID:18782943]"
FT                   /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic
FT                   small ribosomal subunit [PMID:18782943]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030686 90S
FT                   preribosome [PMID:12150911]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000462
FT                   maturation of SSU-rRNA from tricistronic rRNA transcript
FT                   (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]"
FT                   /protein_id="DAA07763.1"
FT                   /translation="MGISRDSRHKRSATGAKRAQFRKKRKFELGRQPANTKIGAKRIHS
FT                   VRTRGGNKKYRALRIETGNFSWASEGISKKTRIAGVVYHPSNNELVRTNTLTKAAIVQI
FT                   DATPFRQWFEAHYGQTLGKKKNVKEEETVAKSKNAERKWAARAASAKIESSVESQFSAG
FT                   RLYACISSRPGQSGRCDGYILEGEELAFYLRRLTAKK"
FT   gene            364589..366517
FT                   /gene="SSA4"
FT                   /gene_synonym="YG107"
FT                   /locus_tag="YER103W"
FT   mRNA            364589..366517
FT                   /gene="SSA4"
FT                   /gene_synonym="YG107"
FT                   /locus_tag="YER103W"
FT                   /product="Hsp70 family chaperone SSA4"
FT   CDS_pept        364589..366517
FT                   /codon_start=1
FT                   /gene="SSA4"
FT                   /gene_synonym="YG107"
FT                   /locus_tag="YER103W"
FT                   /product="Hsp70 family chaperone SSA4"
FT                   /note="Heat shock protein that is highly induced upon
FT                   stress; plays a role in SRP-dependent cotranslational
FT                   protein-membrane targeting and translocation; member of the
FT                   HSP70 family; cytoplasmic protein that concentrates in
FT                   nuclei upon starvation; SSA4 has a paralog, SSA3, that
FT                   arose from the whole genome duplication"
FT                   /db_xref="GOA:P22202"
FT                   /db_xref="InterPro:IPR013126"
FT                   /db_xref="InterPro:IPR018181"
FT                   /db_xref="InterPro:IPR029047"
FT                   /db_xref="InterPro:IPR029048"
FT                   /db_xref="PDB:3UPV"
FT                   /db_xref="UniProtKB/Swiss-Prot:P22202"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:11279056]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:11279056]"
FT                   /experiment="EXISTENCE:expression pattern:GO:0034605
FT                   cellular response to heat [PMID:2121731]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006457
FT                   protein folding [PMID:9789005]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0051082
FT                   unfolded protein binding [PMID:9789005]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006616
FT                   SRP-dependent cotranslational protein targeting to
FT                   membrane, translocation [PMID:8754838]"
FT                   /protein_id="DAA07764.1"
FT                   /translation="MSKAVGIDLGTTYSCVAHFANDRVEIIANDQGNRTTPSYVAFTDT
FT                   ERLIGDAAKNQAAMNPHNTVFDAKRLIGRKFDDPEVTNDAKHYPFKVIDKGGKPVVQVE
FT                   YKGETKTFTPEEISSMILTKMKETAENFLGTEVKDAVVTVPAYFNDSQRQATKDAGTIA
FT                   GLNVLRIINEPTAAAIAYGLDKKSQKEHNVLIFDLGGGTFDVSLLSIDEGVFEVKATAG
FT                   DTHLGGEDFDSRLVNFLAEEFKRKNKKDLTTNQRSLRRLRTAAERAKRTLSSSAQTSIE
FT                   IDSLFEGIDFYTSITRARFEELCADLFRSTLEPVEKVLADSKLDKSQIDEIVLVGGSTR
FT                   IPKVQKLVSDFFNGKEPNRSINPDEAVAYGAAVQAAILTGDQSSTTQDLLLLDVAPLSL
FT                   GIETAGGIMTKLIPRNSTIPTKKSEVFSTYADNQPGVLIQVFEGERTRTKDNNLLGKFE
FT                   LSGIPPAPRGVPQIEVTFDIDANGILNVSAVEKGTGKSNKITITNDKGRLSKEDIDKMV
FT                   AEAEKFKAEDEQEAQRVQAKNQLESYAFTLKNSVSENNFKEKVGEEDARKLEAAAQDAI
FT                   NWLDASQAASTEEYKERQKELEGVANPIMSKFYGAAGGAPGAGPVPGAGAGPTGAPDNG
FT                   PTVEEVD"
FT   gene            366802..367428
FT                   /gene="RTT105"
FT                   /locus_tag="YER104W"
FT   mRNA            366802..367428
FT                   /gene="RTT105"
FT                   /locus_tag="YER104W"
FT                   /product="Rtt105p"
FT   CDS_pept        366802..367428
FT                   /codon_start=1
FT                   /gene="RTT105"
FT                   /locus_tag="YER104W"
FT                   /product="Rtt105p"
FT                   /note="Protein with a role in regulation of Ty1
FT                   transposition"
FT                   /db_xref="GOA:P40063"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40063"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010526 negative
FT                   regulation of transposition, RNA-mediated [PMID:11779788]"
FT                   /protein_id="DAA07765.1"
FT                   /translation="MYSNHNLNSDDCCFDWNEEKAAELQRTGVSFDRSLTPQSLRTSTR
FT                   RLSEENKQQSGTMHIDTSPSVVSDIISSRRDRSQDFFGPHSSSPIAPSERQRADQRSRL
FT                   ESMRLTRRRDKMTKVRGGLEKMEEMIMQGEHLREMQRLKQEAQKNALPSDMAEYMEWQN
FT                   NEDLEDDELLAFIEKQETYKNELEHFLNNANKNVYENNSYPNSHT"
FT   gene            complement(367838..372013)
FT                   /gene="NUP157"
FT                   /locus_tag="YER105C"
FT   mRNA            complement(367838..372013)
FT                   /gene="NUP157"
FT                   /locus_tag="YER105C"
FT                   /product="Nup157p"
FT   CDS_pept        complement(367838..372013)
FT                   /codon_start=1
FT                   /gene="NUP157"
FT                   /locus_tag="YER105C"
FT                   /product="Nup157p"
FT                   /note="Subunit of the inner ring of the nuclear pore
FT                   complex (NPC); contributes to NPC assembly and tethering of
FT                   DNA to the nuclear periphery; both Nup170p and NUP157p are
FT                   similar to human Nup155p; NUP157 has a paralog, NUP170,
FT                   that arose from the whole genome duplication"
FT                   /db_xref="GOA:P40064"
FT                   /db_xref="InterPro:IPR004870"
FT                   /db_xref="InterPro:IPR007187"
FT                   /db_xref="InterPro:IPR014908"
FT                   /db_xref="InterPro:IPR042533"
FT                   /db_xref="InterPro:IPR042537"
FT                   /db_xref="PDB:4MHC"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40064"
FT                   /experiment="EXISTENCE:curator inference:GO:0006913
FT                   nucleocytoplasmic transport [PMID:10684247]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
FT                   [PMID:24062435]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
FT                   [PMID:24062435]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore
FT                   [PMID:10684247]"
FT                   /experiment="EXISTENCE:direct assay:GO:0044611 nuclear pore
FT                   inner ring [PMID:18046406]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0017056
FT                   structural constituent of nuclear pore [PMID:19414608]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0051292
FT                   nuclear pore complex assembly [PMID:19414608]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000972
FT                   transcription-dependent tethering of RNA polymerase II gene
FT                   DNA at nuclear periphery [PMID:20098417|PMID:20932479]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000973
FT                   posttranscriptional tethering of RNA polymerase II gene DNA
FT                   at nuclear periphery [PMID:20932479]"
FT                   /protein_id="DAA07766.1"
FT                   /translation="MYSTPLKKRIDYDRETFTASASLGGNRLRNRPRDDQNNGKPNLSS
FT                   RSFLSERKTRKDVLNKYGEAGNTIESELRDVTTHVKISGLTSSEPLQLASEFVQDLSFR
FT                   DRNTPILDNPDYYSKGLDYNFSDEVGGLGAFTPFQRQQVTNIPDEVLSQVSNTEIKSDM
FT                   GIFLELNYCWITSDNKLILWNINNSSEYHCIDEIEHTILKVKLVKPSPNTFVSSVENLL
FT                   IVATLFDIYILTISFNDRTHELNIFNTGLKVNVTGFNVSNIISYERTGQIFFTGATDGV
FT                   NVWELQYNCSENLFNSKSNKICLTKSNLANLLPTKLIPSIPGGKLIQKVLEGDAGTEEE
FT                   TISQLEVDQSRGVLHTLSTKSIVRSYLITSNGLVGPVLIDAAHIRRGMNALGVKNSPLL
FT                   SNRAFKIAKIVSISMCENNDLFLAVITTTGVRLYFKGSISRRSIGSLKLDSVKFPPTSI
FT                   SSSLEQNKSFIIGHHPLNTHDTGPLSTQKASSTYINTTCASTIISPGIYFTCVRKRANS
FT                   GELSKGITNKALLENKEEHKLYVSAPDYGILKNYGKYVENTALLDTTDEIKEIVPLTRS
FT                   FNYTSTPQGYANVFASQYSAEPLKVAVLTSNALEIYCYRTPDEVFESLIENPLPFIHSY
FT                   GLSEACSTALYLACKFNKSEHIKSSALAFFSAGIPGVVEIKPKSSRESGSVPPISQNLF
FT                   DKSGECDGIVLSPRFYGSALLITRLFSQIWEERVFVFKRASKTEKMDAFGISITRPQVE
FT                   YYLSSISVLADFFNIHRPSFVSFVPPKGSNAITASDAESIAMNALILLINSIKDALSLI
FT                   NVFYEDIDAFKSLLNTLMGAGGVYDSKTREYFFDLKFHDLFTPNAKTKQLIKEILIEVV
FT                   NANIASGTSADYIVNVLKERFGSFCHSADILCYRAGEHLEAAQKFEMIDSKISRNHLDT
FT                   AIDLYERCAENIELCELRRVVDIMVKLNYQPKTVGFLLRFADKIDKGNQAQEYVSRGCN
FT                   TADPRKVFYDKRINVYTLIFEIVKSVDDYTSIEQSPSIANISIFSPASSLKKRVYSVIM
FT                   NSNNRFFHYCFYDWLVANKRQDYLLRLDSQFVLPYLKERAEKSLEISNLLWFYLFKEEH
FT                   FLEAADVLYALASSDFDLKLSERIECLARANGLCDSSTSFDQKPALVQLSENIHELFDI
FT                   ASIQDDLLNLVRNETRIDEDYRKQLTLKLNGRVLPLSDLFNDCADPLDYYEIKLRIFKV
FT                   SQFKDEKVIQGEWNRLLDSMKNAPSPDVGSVGQESFLSSISNTLIRIGKTTRDTDVVFP
FT                   VHFLMNKILESFIDKSSAADGSVCSMFLLAGVSHLKLYYILSRIIENSEGNVELAKKEM
FT                   VWLIKDWYQSDSDLRGSIAPEQIKKLEKYDPNTDPVQDYVKDRHHGLK"
FT   gene            372326..373234
FT                   /gene="MAM1"
FT                   /locus_tag="YER106W"
FT   mRNA            372326..373234
FT                   /gene="MAM1"
FT                   /locus_tag="YER106W"
FT                   /product="Mam1p"
FT   CDS_pept        372326..373234
FT                   /codon_start=1
FT                   /gene="MAM1"
FT                   /locus_tag="YER106W"
FT                   /product="Mam1p"
FT                   /note="Monopolin; meiosis-specific kinetochore-associated
FT                   protein involved in monopolar attachment of sister
FT                   kinetochores to the meiotic spindle; subunit of monopolin,
FT                   a complex that prevents biorientation of sister
FT                   kinetochores to ensure homolog biorientation during meiosis
FT                   I; regulates the conformation, enzyme kinetics and
FT                   substrate specificity of the Dsn1p kinase, Hrr1p; expressed
FT                   only during the first meiotic division"
FT                   /db_xref="GOA:P40065"
FT                   /db_xref="InterPro:IPR018847"
FT                   /db_xref="PDB:5CYZ"
FT                   /db_xref="PDB:5CZO"
FT                   /db_xref="PDB:5KTB"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40065"
FT                   /experiment="EXISTENCE:direct assay:GO:0000778 condensed
FT                   nuclear chromosome kinetochore
FT                   [PMID:11163190|PMID:12663816|PMID:23861669]"
FT                   /experiment="EXISTENCE:direct assay:GO:0033551 monopolin
FT                   complex [PMID:12689592]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045859 regulation
FT                   of protein kinase activity [PMID:27491543]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0010789
FT                   meiotic sister chromatid cohesion involved in meiosis I
FT                   [PMID:15062096]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0051455
FT                   attachment of spindle microtubules to kinetochore involved
FT                   in homologous chromosome segregation [PMID:23861669]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010789 meiotic
FT                   sister chromatid cohesion involved in meiosis I
FT                   [PMID:15062096]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic
FT                   chromosome segregation [PMID:11470404]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045143
FT                   homologous chromosome segregation [PMID:11163190]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051455
FT                   attachment of spindle microtubules to kinetochore involved
FT                   in homologous chromosome segregation [PMID:11163190]"
FT                   /protein_id="DAA07767.1"
FT                   /translation="MREKRTISNKDTNYLKFPNKLQRYSRFLSRKISNTSPEKQPKKNI
FT                   KEHCLSSYHKEHSVKPKQNSGNVAAKEDKDTQHLQNNVANEEATECLTRSNLKKLQEKI
FT                   FDRELNDIACDHCLCSTENRRDIKYSRLWFLFELEMSENWNENLRLSCYNKYVYSAIDE
FT                   SWKMENILLKEQEKHYEYFPIGQLLIPNNIDYTNKQKRKENIEDLTIEIDSIIETNHQK
FT                   KRFLPQSVLIKREDEIAFDDFHLDARKVLNDLSATSENPFSSSPNTKKIKSKGKTLEVV
FT                   PKKKNKKIIGALERKLHIDEN"
FT   gene            complement(373448..374545)
FT                   /gene="GLE2"
FT                   /gene_synonym="RAE1"
FT                   /locus_tag="YER107C"
FT   mRNA            complement(373448..374545)
FT                   /gene="GLE2"
FT                   /gene_synonym="RAE1"
FT                   /locus_tag="YER107C"
FT                   /product="RNA export factor GLE2"
FT   CDS_pept        complement(373448..374545)
FT                   /codon_start=1
FT                   /gene="GLE2"
FT                   /gene_synonym="RAE1"
FT                   /locus_tag="YER107C"
FT                   /product="RNA export factor GLE2"
FT                   /note="RNA export factor associated with the nuclear pore
FT                   complex (NPC); associates with NUP116p; required for
FT                   polyadenylated RNA export but not for protein import;
FT                   homologous to S. pombe Rae1p and human RAE1"
FT                   /db_xref="GOA:P40066"
FT                   /db_xref="InterPro:IPR001680"
FT                   /db_xref="InterPro:IPR015943"
FT                   /db_xref="InterPro:IPR017986"
FT                   /db_xref="InterPro:IPR020472"
FT                   /db_xref="InterPro:IPR036322"
FT                   /db_xref="InterPro:IPR037631"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40066"
FT                   /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore
FT                   [PMID:10684247|PMID:8970155]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:15210706]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000972
FT                   transcription-dependent tethering of RNA polymerase II gene
FT                   DNA at nuclear periphery [PMID:20098417|PMID:20932479]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000973
FT                   posttranscriptional tethering of RNA polymerase II gene DNA
FT                   at nuclear periphery [PMID:20932479]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+
FT                   mRNA export from nucleus [PMID:8970155]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031081 nuclear
FT                   pore distribution [PMID:9725905]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000728
FT                   regulation of mRNA export from nucleus in response to heat
FT                   stress [PMID:15210706]"
FT                   /protein_id="DAA07768.1"
FT                   /translation="MSFFNRSNTTSALGTSTAMANEKDLANDIVINSPAEDSISDIAFS
FT                   PQQDFMFSASSWDGKVRIWDVQNGVPQGRAQHESSSPVLCTRWSNDGTKVASGGCDNAL
FT                   KLYDIASGQTQQIGMHSAPIKVLRFVQCGPSNTECIVTGSWDKTIKYWDMRQPQPVSTV
FT                   MMPERVYSMDNKQSLLVVATAERHIAIINLANPTTIFKATTSPLKWQTRCVACYNEADG
FT                   YAIGSVEGRCSIRYIDDGMQKKSGFSFKCHRQTNPNRAPGSNGQSLVYPVNSIAFHPLY
FT                   GTFVTAGGDGTFNFWDKNQRHRLKGYPTLQASIPVCSFNRNGSVFAYALSYDWHQGHMG
FT                   NRPDYPNVIRLHATTDEEVKEKKKR"
FT   gene            complement(375215..377614)
FT                   /pseudo
FT                   /gene="FLO8"
FT                   /gene_synonym="PHD5"
FT                   /gene_synonym="STA10"
FT                   /gene_synonym="YER108C"
FT                   /locus_tag="YER109C"
FT   CDS_pept        complement(375215..377614)
FT                   /pseudo
FT                   /codon_start=1
FT                   /gene="FLO8"
FT                   /gene_synonym="PHD5"
FT                   /gene_synonym="YER108C"
FT                   /gene_synonym="STA10"
FT                   /locus_tag="YER109C"
FT                   /note="Transcription factor; required for flocculation,
FT                   diploid filamentous growth, and haploid invasive growth;
FT                   forms a heterodimer with Mss1p that interacts with the
FT                   Swi/Snf complex during transcriptional activation of FLO1,
FT                   FLO11, and STA1; S. cerevisiae genome reference strain
FT                   S288C contains an internal in-frame stop at codon 142,
FT                   which in other strains encodes tryptophan"
FT                   /experiment="EXISTENCE:direct assay:GO:0000978 RNA
FT                   polymerase II proximal promoter sequence-specific DNA
FT                   binding [PMID:12024012]"
FT                   /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding
FT                   transcription activator activity, RNA polymerase
FT                   II-specific [PMID:10515942]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:12024012|PMID:8913742|PMID:11914276]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:11914276]"
FT                   /experiment="EXISTENCE:direct assay:GO:1900461 positive
FT                   regulation of pseudohyphal growth by positive regulation of
FT                   transcription from RNA polymerase II promoter
FT                   [PMID:12024012]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:10373537|PMID:10591965|PMID:16568252]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1900189 positive
FT                   regulation of cell adhesion involved in single-species
FT                   biofilm formation [PMID:18202364]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1900461 positive
FT                   regulation of pseudohyphal growth by positive regulation of
FT                   transcription from RNA polymerase II promoter
FT                   [PMID:10064592|PMID:10373537|PMID:10591965|PMID:12024012]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1900524 positive
FT                   regulation of flocculation via cell wall
FT                   protein-carbohydrate interaction by positive regulation of
FT                   transcription from RNA polymerase II promoter
FT                   [PMID:10591965|PMID:16568252]"
FT   gene            complement(378762..382103)
FT                   /gene="KAP123"
FT                   /gene_synonym="YRB4"
FT                   /locus_tag="YER110C"
FT   mRNA            complement(378762..382103)
FT                   /gene="KAP123"
FT                   /gene_synonym="YRB4"
FT                   /locus_tag="YER110C"
FT                   /product="Kap123p"
FT   CDS_pept        complement(378762..382103)
FT                   /codon_start=1
FT                   /gene="KAP123"
FT                   /gene_synonym="YRB4"
FT                   /locus_tag="YER110C"
FT                   /product="Kap123p"
FT                   /note="Karyopherin beta; mediates nuclear import of
FT                   ribosomal proteins prior to assembly into ribosomes and
FT                   import of histones H3 and H4; localizes to the nuclear
FT                   pore, nucleus, and cytoplasm; exhibits genetic interactions
FT                   with RAI1"
FT                   /db_xref="GOA:P40069"
FT                   /db_xref="InterPro:IPR001494"
FT                   /db_xref="InterPro:IPR016024"
FT                   /db_xref="InterPro:IPR021133"
FT                   /db_xref="InterPro:IPR034085"
FT                   /db_xref="InterPro:IPR040122"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40069"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:9238021|PMID:10684247]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:10684247|PMID:9238021]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006606 protein
FT                   import into nucleus [PMID:9321403]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008139 nuclear
FT                   localization sequence binding [PMID:11694505]"
FT                   /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
FT                   stress granule [PMID:26777405]"
FT                   /experiment="EXISTENCE:direct assay:GO:0061608 nuclear
FT                   import signal receptor activity [PMID:9321403]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein
FT                   import into nucleus [PMID:11352936]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006607
FT                   NLS-bearing protein import into nucleus [PMID:11694505]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear
FT                   import signal receptor activity [PMID:9321403]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000220
FT                   regulation of pseudohyphal growth [PMID:22043304]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0061608
FT                   nuclear import signal receptor activity [PMID:9182759]"
FT                   /protein_id="DAA07770.1"
FT                   /translation="MDQQFLSQLEQTLHAITSGVGLKEATKTLQTQFYTQPTTLPALIH
FT                   ILQNGSDDSLKQLAGVEARKLVSKHWNAIDESTRASIKTSLLQTAFSEPKENVRHSNAR
FT                   VIASIGTEELDGNKWPDLVPNLIQTASGEDVQTRQTAIFILFSLLEDFTSSLSGHIDDF
FT                   LALFSQTINDPSSLEIRSLSAQALNHVSALIEEQETINPVQAQKFAASIPSVVNVLDAV
FT                   IKADDTMNAKLIFNCLNDFLLLDSQLTGNFIVDLIKLSLQIAVNSEIDEDVRVFALQFI
FT                   ISSLSYRKSKVSQSKLGPEITVAALKVACEEIDVDDELNNEDETGENEENTPSSSAIRL
FT                   LAFASSELPPSQVASVIVEHIPAMLQSANVFERRAILLAISVAVTGSPDYILSQFDKII
FT                   PATINGLKDTEPIVKLAALKCIHQLTTDLQDEVAKFHEEYLPLIIDIIDSAKNIVIYNY
FT                   ATVALDGLLEFIAYDAIAKYLDPLMNKLFYMLESNESSKLRCAVVSAIGSAAFAAGSAF
FT                   IPYFKTSVHYLEKFIQNCSQIEGMSEDDIELRANTFENISTMARAVRSDAFAEFAEPLV
FT                   NSAYEAIKTDSARLRESGYAFIANLAKVYGENFAPFLKTILPEIFKTLELDEYQFNFDG
FT                   DAEDLAAFADSANEEELQNKFTVNTGISYEKEVASAALSELALGTKEHFLPYVEQSLKV
FT                   LNEQVDESYGLRETALNTIWNVVKSVLLASKVEPESYPKGIPASSYVNADVLAVIQAAR
FT                   ETSMGNLSDEFETSMVITVMEDFANMIKQFGAIIIMDNGDSSMLEALCMQVLSVLKGTH
FT                   TCQTIDIEEDVPRDEELDASETEATLQDVALEVLVSLSQALAGDFAKVFDNFRPVVFGL
FT                   FQSKSKNKRSSAVGAASELALGMKEQNPFVHEMLEALVIRLTSDKSLEVRGNAAYGVGL
FT                   LCEYASMDISAVYEPVLKALYELLSAADQKALAAEDDEATREIIDRAYANASGCVARMA
FT                   LKNSALVPLEQTVPALLAHLPLNTGFEEYNPIFELIMKLYQENSPVITNETPRIIEIFS
FT                   AVFTKENDRIKLEKESTLGREENMERLKQFQTEEMKHKVIELLKYLNTTYNGIVAQNPV
FT                   LAAVIA"
FT   gene            complement(382595..385876)
FT                   /gene="SWI4"
FT                   /gene_synonym="ART1"
FT                   /locus_tag="YER111C"
FT   mRNA            complement(382595..385876)
FT                   /gene="SWI4"
FT                   /gene_synonym="ART1"
FT                   /locus_tag="YER111C"
FT                   /product="SBF complex DNA-binding subunit SWI4"
FT   CDS_pept        complement(382595..385876)
FT                   /codon_start=1
FT                   /gene="SWI4"
FT                   /gene_synonym="ART1"
FT                   /locus_tag="YER111C"
FT                   /product="SBF complex DNA-binding subunit SWI4"
FT                   /note="DNA binding component of the SBF complex
FT                   (Swi4p-Swi6p); a transcriptional activator that in concert
FT                   with MBF (Mbp1-Swi6p) regulates late G1-specific
FT                   transcription of targets including cyclins and genes
FT                   required for DNA synthesis and repair; Slt2p-independent
FT                   regulator of cold growth; acetylation at two sites, K1016
FT                   and K1066, regulates interaction with Swi6p"
FT                   /db_xref="GOA:P25302"
FT                   /db_xref="InterPro:IPR002110"
FT                   /db_xref="InterPro:IPR003163"
FT                   /db_xref="InterPro:IPR018004"
FT                   /db_xref="InterPro:IPR020683"
FT                   /db_xref="InterPro:IPR029792"
FT                   /db_xref="InterPro:IPR036770"
FT                   /db_xref="InterPro:IPR036887"
FT                   /db_xref="UniProtKB/Swiss-Prot:P25302"
FT                   /experiment="EXISTENCE:direct assay:GO:0000790 nuclear
FT                   chromatin [PMID:12464632]"
FT                   /experiment="EXISTENCE:direct assay:GO:0033309 SBF
FT                   transcription complex
FT                   [PMID:1832338|PMID:2689885|PMID:8423776]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043565
FT                   sequence-specific DNA binding [PMID:19111667]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001228
FT                   DNA-binding transcription activator activity, RNA
FT                   polymerase II-specific [PMID:2649246|PMID:8423776]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0033309 SBF
FT                   transcription complex [PMID:8423776]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0061408 positive
FT                   regulation of transcription from RNA polymerase II promoter
FT                   in response to heat stress [PMID:20641022]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0071931 positive
FT                   regulation of transcription involved in G1/S transition of
FT                   mitotic cell cycle [PMID:2649246|PMID:3542227]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0033309 SBF
FT                   transcription complex [PMID:1465410]"
FT                   /protein_id="DAA07771.1"
FT                   /translation="MPFDVLISNQKDNTNHQNITPISKSVLLAPHSNHPVIEIATYSET
FT                   DVYECYIRGFETKIVMRRTKDDWINITQVFKIAQFSKTKRTKILEKESNDMQHEKVQGG
FT                   YGRFQGTWIPLDSAKFLVNKYEIIDPVVNSILTFQFDPNNPPPKRSKNSILRKTSPGTK
FT                   ITSPSSYNKTPRKKNSSSSTSATTTAANKKGKKNASINQPNPSPLQNLVFQTPQQFQVN
FT                   SSMNIMNNNDNHTTMNFNNDTRHNLINNISNNSNQSTIIQQQKSIHENSFNNNYSATQK
FT                   PLQFFPIPTNLQNKNVALNNPNNNDSNSYSHNIDNVINSSNNNNNGNNNNLIIVPDGPM
FT                   QSQQQQQHHHEYLTNNFNHSMMDSITNGNSKKRRKKLNQSNEQQFYNQQEKIQRHFKLM
FT                   KQPLLWQSFQNPNDHHNEYCDSNGSNNNNNTVASNGSSIEVFSSNENDNSMNMSSRSMT
FT                   PFSAGNTSSQNKLENKMTDQEYKQTILTILSSERSSDVDQALLATLYPAPKNFNINFEI
FT                   DDQGHTPLHWATAMANIPLIKMLITLNANALQCNKLGFNCITKSIFYNNCYKENAFDEI
FT                   ISILKICLITPDVNGRLPFHYLIELSVNKSKNPMIIKSYMDSIILSLGQQDYNLLKICL
FT                   NYQDNIGNTPLHLSALNLNFEVYNRLVYLGASTDILNLDNESPASIMNKFNTPAGGSNS
FT                   RNNNTKADRKLARNLPQKNYYQQQQQQQQPQNNVKIPKIIKTQHPDKEDSTADVNIAKT
FT                   DSEVNESQYLHSNQPNSTNMNTIMEDLSNINSFVTSSVIKDIKSTPSKILENSPILYRR
FT                   RSQSISDEKEKAKDNENQVEKKKDPLNSVKTAMPSLESPSSLLPIQMSPLGKYSKPLSQ
FT                   QINKLNTKVSSLQRIMGEEIKNLDNEVVETESSISNNKKRLITIAHQIEDAFDSVSNKT
FT                   PINSISDLQSRIKETSSKLNSEKQNFIQSLEKSQALKLATIVQDEESKVDMNTNSSSHP
FT                   EKQEDEEPIPKSTSETSSPKNTKADAKFSNTVQESYDVNETLRLATELTILQFKRRMTT
FT                   LKISEAKSKINSSVKLDKYRNLIGITIENIDSKLDDIEKDLRANA"
FT   gene            387232..387795
FT                   /gene="LSM4"
FT                   /gene_synonym="SDB23"
FT                   /gene_synonym="USS1"
FT                   /locus_tag="YER112W"
FT   mRNA            387232..387795
FT                   /gene="LSM4"
FT                   /gene_synonym="SDB23"
FT                   /gene_synonym="USS1"
FT                   /locus_tag="YER112W"
FT                   /product="U6 snRNA complex subunit LSM4"
FT   CDS_pept        387232..387795
FT                   /codon_start=1
FT                   /gene="LSM4"
FT                   /gene_synonym="SDB23"
FT                   /gene_synonym="USS1"
FT                   /locus_tag="YER112W"
FT                   /product="U6 snRNA complex subunit LSM4"
FT                   /note="Lsm (Like Sm) protein; part of heteroheptameric
FT                   complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic
FT                   Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex
FT                   part of U6 snRNP and possibly involved in processing tRNA,
FT                   snoRNA, and rRNA; forms cytoplasmic foci upon DNA
FT                   replication stress"
FT                   /db_xref="GOA:P40070"
FT                   /db_xref="InterPro:IPR001163"
FT                   /db_xref="InterPro:IPR010920"
FT                   /db_xref="InterPro:IPR027141"
FT                   /db_xref="InterPro:IPR034101"
FT                   /db_xref="PDB:3JCM"
FT                   /db_xref="PDB:4C8Q"
FT                   /db_xref="PDB:4C92"
FT                   /db_xref="PDB:4M75"
FT                   /db_xref="PDB:4M77"
FT                   /db_xref="PDB:4M78"
FT                   /db_xref="PDB:4M7A"
FT                   /db_xref="PDB:4M7D"
FT                   /db_xref="PDB:5GAN"
FT                   /db_xref="PDB:5NRL"
FT                   /db_xref="PDB:5VSU"
FT                   /db_xref="PDB:5ZWM"
FT                   /db_xref="PDB:5ZWO"
FT                   /db_xref="PDB:6ASO"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40070"
FT                   /experiment="EXISTENCE:direct assay:GO:0000932 P-body
FT                   [PMID:18611963]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP
FT                   [PMID:10369684|PMID:11720284]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:15075370]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA
FT                   binding [PMID:10369684]"
FT                   /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5
FT                   tri-snRNP complex [PMID:10377396|PMID:10449419]"
FT                   /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1
FT                   complex [PMID:24139796]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0033962
FT                   cytoplasmic mRNA processing body assembly
FT                   [PMID:17984320|PMID:18981231]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA
FT                   splicing, via spliceosome [PMID:10428970]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0017070 U6 snRNA
FT                   binding [PMID:10369684]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0033962
FT                   cytoplasmic mRNA processing body assembly
FT                   [PMID:17984320|PMID:18981231]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005732
FT                   small nucleolar ribonucleoprotein complex [PMID:15075370]"
FT                   /protein_id="DAA07772.1"
FT                   /translation="MLPLYLLTNAKGQQMQIELKNGEIIQGILTNVDNWMNLTLSNVTE
FT                   YSEESAINSEDNAESSKAVKLNEIYIRGTFIKFIKLQDNIIDKVKQQINSNNNSNSNGP
FT                   GHKRYYNNRDSNNNRGNYNRRNNNNGNSNRRPYSQNRQYNNSNSSNINNSINSINSNNQ
FT                   NMNNGLGGSVQHHFNSSSPQKVEF"
FT   gene            complement(387932..390052)
FT                   /gene="TMN3"
FT                   /locus_tag="YER113C"
FT   mRNA            complement(387932..390052)
FT                   /gene="TMN3"
FT                   /locus_tag="YER113C"
FT                   /product="Tmn3p"
FT   CDS_pept        complement(387932..390052)
FT                   /codon_start=1
FT                   /gene="TMN3"
FT                   /locus_tag="YER113C"
FT                   /product="Tmn3p"
FT                   /note="Protein with a role in cellular adhesion and
FT                   filamentous growth; similar to Emp70p and Tmn2p; member of
FT                   Transmembrane Nine family with 9 transmembrane segments;
FT                   localizes to Golgi; induced by 8-methoxypsoralen plus UVA
FT                   irradiation"
FT                   /db_xref="GOA:P40071"
FT                   /db_xref="InterPro:IPR004240"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40071"
FT                   /experiment="EXISTENCE:direct assay:GO:0005794 Golgi
FT                   apparatus [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030137 COPI-coated
FT                   vesicle [PMID:14562095]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006878
FT                   cellular copper ion homeostasis [PMID:20681974]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007034
FT                   vacuolar transport [PMID:20526336]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007124
FT                   pseudohyphal growth [PMID:18178563]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive
FT                   growth in response to glucose limitation [PMID:18178563]"
FT                   /protein_id="DAA07773.1"
FT                   /translation="MRVRPKRSVITLMAIVVVMLILRNQFYSSRTRGHGQEPVISSSQK
FT                   NLYDGWITPNFYRKGDPLELIVNKVESDLTQLPYAYYDLPFTCPPTMHKKPLHLSLNEI
FT                   IRGDRKWESDYKLKFGEDNPCETLCARKTTKEGMQTLDKLVREGYVVQWLIDDELPAAT
FT                   TFISTTDHKKYYASGFPLGFIDPDTDKTYLHNHVMLVIRFHASDNDKNTIVGFEVYPRS
FT                   VSDYHCPGASKNYEQYEIVIPEDENELTYLPFTYSVYWREEFEVDWNHRWDYFLNAGEL
FT                   SDEQSIQFHWMSLANSVGIVLSISFITLIIYVRVMYTDKSNSKSPKYMINIEGIETEDD
FT                   LDDDKYGKYSVYTVAKDWIQNGRPNLFGLKVLILLVSFGVQFLFTIIGSLTISCSMNKL
FT                   HNVRNSVLTMAILFFVLGAFMASFVGTRLSMVTKTKRTKANYLDDNRYLKDYKKFSPIF
FT                   TILCGSSLPGIVMVSTFLLNSIVWAHDSTSALPFKTIVFFMSIYFIVCIPLSLFGGIVA
FT                   NNIPLPQYWLSGITKDESNSDGNGLFVPKSRAKFNPLVYCGIYLCGIFPLLVIYVEMQY
FT                   VYKSLWLEKTTFYYFYGFLFLSIILLCVLTMEISIIGSYLLMRFCFEDKVVRNNWRWKC
FT                   FEMGFSGGVYMELYSLYYIFAVLNIHGFSSILISICYSLIFNVMCSLGLGALSYLTASW
FT                   FINKIYHQKVNL"
FT   gene            complement(390590..393712)
FT                   /gene="BOI2"
FT                   /gene_synonym="BEB1"
FT                   /locus_tag="YER114C"
FT   mRNA            complement(390590..393712)
FT                   /gene="BOI2"
FT                   /gene_synonym="BEB1"
FT                   /locus_tag="YER114C"
FT                   /product="Boi2p"
FT   CDS_pept        complement(390590..393712)
FT                   /codon_start=1
FT                   /gene="BOI2"
FT                   /gene_synonym="BEB1"
FT                   /locus_tag="YER114C"
FT                   /product="Boi2p"
FT                   /note="Protein implicated in polar growth, functionally
FT                   redundant with Boi1p; interacts with bud-emergence protein
FT                   Bem1p; contains an SH3 (src homology 3) domain and a PH
FT                   (pleckstrin homology) domain; BOI2 has a paralog, BOI1,
FT                   that arose from the whole genome duplication"
FT                   /db_xref="GOA:P39969"
FT                   /db_xref="InterPro:IPR001452"
FT                   /db_xref="InterPro:IPR001660"
FT                   /db_xref="InterPro:IPR001849"
FT                   /db_xref="InterPro:IPR011993"
FT                   /db_xref="InterPro:IPR013761"
FT                   /db_xref="InterPro:IPR035551"
FT                   /db_xref="InterPro:IPR036028"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39969"
FT                   /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud
FT                   [PMID:12097146]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud
FT                   neck [PMID:12097146]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030427 site of
FT                   polarized growth [PMID:12097146]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000920
FT                   septum digestion after cytokinesis [PMID:16615892]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007118
FT                   budding cell apical bud growth [PMID:17417630]"
FT                   /protein_id="DAA07774.1"
FT                   /translation="MSNDREVPTLSQLNTTVSRDKDVSDTLSPDFDSKGSATGRDGGNF
FT                   PMYIAINEYFKRMEDELDMKPGDKIKVITDDEEYKDGWYFGRNLRTNEEGLYPVVFTQK
FT                   ITVEKAPTLMRAKSTKRIYSPLTNEDPLLSSTFISENDSNSELPTPQPIETAASISRTA
FT                   NGKIERNLSLKNTMSDIDNALLEFKDDSIGPPDRFINSGRDEEHSITHETILSATDGLD
FT                   VVESNSKPTTSSSTGFLNGDLENQATLINGIDTTKLNPVEAEFWSPEEITAYFIMEGYD
FT                   VQSASRFQKHKISGKILLELELVHLKELDINSFGTRFEIFKEIEKIKEAIRTNGRSLNR
FT                   ASKTNNANIYNQLMPPANVDQRASYRGHVRKTSQSLEDLPSQQNFIPTPRNTRNSSASK
FT                   HRPKSLVFDSQEANANIAPDVQIPQVVEEMAGNENLFVSPRRAPKPPSYPSPAQPPKSP
FT                   LLNNTRTSPSPAQLYSWQSPTLSFSGPKRTSYIDQYSSSDSNFNSRSALPKNNQGGGKA
FT                   LSPIPSPTRNSVRNEDSEGKLTSSSKRNSVPYYGYAPESSSDRKSSCSSHEEEQFQETM
FT                   NTFERPTSSIYADGSTIASISNDKLAHEKEGKKKPTRHSSSLSSKSKSDSRRNSSLKRS
FT                   SSASRTSSFKKSSFMLSPFRQQFTDNAARSSSPEENPITSMPSEKNSSPIVDKKSSKKS
FT                   RSKRRSVSAKEAEIFTETVKDDKNKRSASEAIKGETLKGKSLRQMTARPVAKKKQTSAF
FT                   IEGLRSISVKEAMKDADFSGWMSKKGSGAMSTWKTRFFTLHGTRLSYFSSTTDTRERGL
FT                   IDITAHRVVPAKEDDKLVSLYAASTGKGRYCFKLLPPQPGSKKGLTFTQPRTHYFAVDN
FT                   KEEMRGWMAALIKTTIDIDTSVPIISSYTTPTVSLSKAQEMLAEAREETKLREQQMLEN
FT                   EEDEDQFLWDQQQLQQQQHDNNQGQADRTISASTQRTSDEDNTISTPNLSSANNTTIGS
FT                   NGFSSPFLLASGLLSPGVARNSSMRGTEKKGKFSTEEDYFGDNSKHKTDKI"
FT   gene            complement(394292..394867)
FT                   /gene="SPR6"
FT                   /locus_tag="YER115C"
FT   mRNA            complement(394292..394867)
FT                   /gene="SPR6"
FT                   /locus_tag="YER115C"
FT                   /product="Spr6p"
FT   CDS_pept        complement(394292..394867)
FT                   /codon_start=1
FT                   /gene="SPR6"
FT                   /locus_tag="YER115C"
FT                   /product="Spr6p"
FT                   /note="hypothetical protein; expressed during sporulation;
FT                   not required for sporulation, but gene exhibits genetic
FT                   interactions with other genes required for sporulation"
FT                   /db_xref="GOA:Q01684"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q01684"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:24390141]"
FT                   /experiment="EXISTENCE:expression pattern:GO:0030437
FT                   ascospore formation [PMID:2253272]"
FT                   /protein_id="DAA07775.1"
FT                   /translation="MAVSNIWQSYSSSNLHWIYPLYTNNCSQNVKSSFTAEILLKRRCN
FT                   DIQDILNDRMIELLLQGACDPNKQQNYLQGMSPSRKKKTHVKKFLKKQKKSRKPITLEH
FT                   GCLSGPVTLRFGNFAGIRDLRGTRCPLHGIKHGVHPKPGERCACQQATLFPSPLARFSC
FT                   DQSAVLGCAASSTRVYDSIADEFSSLYF"
FT   gene            complement(395348..396172)
FT                   /gene="SLX8"
FT                   /locus_tag="YER116C"
FT   mRNA            complement(395348..396172)
FT                   /gene="SLX8"
FT                   /locus_tag="YER116C"
FT                   /product="SUMO-targeted ubiquitin ligase complex subunit
FT                   SLX8"
FT   CDS_pept        complement(395348..396172)
FT                   /codon_start=1
FT                   /gene="SLX8"
FT                   /locus_tag="YER116C"
FT                   /product="SUMO-targeted ubiquitin ligase complex subunit
FT                   SLX8"
FT                   /EC_number="2.3.2.27"
FT                   /note="Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase
FT                   (STUbL) complex; role in proteolysis of spindle positioning
FT                   protein Kar9, DNA repair proteins Rad52p and Rad57p;
FT                   stimulated by SUMO-modified substrates; contains a
FT                   C-terminal RING domain; forms nuclear foci upon DNA
FT                   replication stress; required for maintenance of genome
FT                   integrity like human ortholog RNF"
FT                   /db_xref="GOA:P40072"
FT                   /db_xref="InterPro:IPR001841"
FT                   /db_xref="InterPro:IPR013083"
FT                   /db_xref="InterPro:IPR017907"
FT                   /db_xref="InterPro:IPR018957"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40072"
FT                   /experiment="EXISTENCE:direct assay:GO:0000778 condensed
FT                   nuclear chromosome kinetochore [PMID:26906737]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004842
FT                   ubiquitin-protein transferase activity
FT                   [PMID:17728242|PMID:18032921|PMID:26906737|PMID:17848550]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:19270524|PMID:26906737|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016567 protein
FT                   ubiquitination
FT                   [PMID:17728242|PMID:17848550|PMID:18032921|PMID:26906737]"
FT                   /experiment="EXISTENCE:direct assay:GO:0033768
FT                   SUMO-targeted ubiquitin ligase complex [PMID:17848550]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006974
FT                   cellular response to DNA damage stimulus [PMID:11139495]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0016567
FT                   protein ubiquitination [PMID:26906737]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0016925
FT                   protein sumoylation [PMID:16387868]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere
FT                   maintenance [PMID:16428246]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006974 cellular
FT                   response to DNA damage stimulus
FT                   [PMID:11139495|PMID:16325482]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein
FT                   ubiquitination [PMID:26906737]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016925 protein
FT                   sumoylation [PMID:16387868]"
FT                   /protein_id="DAA07776.1"
FT                   /translation="MARRPDNQNPEGENLRIKRVRLESVRQNDEEEENEVSRTQNIVTD
FT                   NRHDSPEAVVEIIGERALENTSEEDGDDDLSLFRALEEDPGSDHNTSNNDSGNHDRETM
FT                   HTEEPEASSGNNITLTNNVEELHTMDVLSQTANTPSASPMLDAAPPTTKPGTNSKEQTV
FT                   DLTADAIDLDAEEQQVLQISDDDFQEETKEAPKEYGAAKDYRCPICFEPPETALMTLCG
FT                   HVFCCPCLFQMVNSSRTCRQFGHCALCRSKVYLKDVRLIILRKKQVKKKVKS"
FT   gene            396769..397653
FT                   /gene="RPL23B"
FT                   /locus_tag="YER117W"
FT   mRNA            join(396769..396810,397282..397653)
FT                   /gene="RPL23B"
FT                   /locus_tag="YER117W"
FT                   /product="ribosomal 60S subunit protein L23B"
FT   CDS_pept        join(396769..396810,397282..397653)
FT                   /codon_start=1
FT                   /gene="RPL23B"
FT                   /locus_tag="YER117W"
FT                   /product="ribosomal 60S subunit protein L23B"
FT                   /note="Ribosomal 60S subunit protein L23B; homologous to
FT                   mammalian ribosomal protein L23 and bacterial L14; RPL23B
FT                   has a paralog, RPL23A, that arose from the whole genome
FT                   duplication"
FT                   /db_xref="GOA:P0CX42"
FT                   /db_xref="InterPro:IPR000218"
FT                   /db_xref="InterPro:IPR019972"
FT                   /db_xref="InterPro:IPR036853"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CX42"
FT                   /experiment="EXISTENCE:curator inference:GO:0002181
FT                   cytoplasmic translation [PMID:11983894]"
FT                   /experiment="EXISTENCE:curator inference:GO:0003735
FT                   structural constituent of ribosome [PMID:11983894]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:22932476]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:22932476]"
FT                   /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic
FT                   large ribosomal subunit [PMID:11983894]"
FT                   /protein_id="DAA07777.1"
FT                   /translation="MSGNGAQGTKFRISLGLPVGAIMNCADNSGARNLYIIAVKGSGSR
FT                   LNRLPAASLGDMVMATVKKGKPELRKKVMPAIVVRQAKSWRRRDGVFLYFEDNAGVIAN
FT                   PKGEMKGSAITGPVGKECADLWPRVASNSGVVV"
FT   gene            complement(397952..399055)
FT                   /gene="SHO1"
FT                   /gene_synonym="SSU81"
FT                   /locus_tag="YER118C"
FT   mRNA            complement(397952..399055)
FT                   /gene="SHO1"
FT                   /gene_synonym="SSU81"
FT                   /locus_tag="YER118C"
FT                   /product="osmosensor SHO1"
FT   CDS_pept        complement(397952..399055)
FT                   /codon_start=1
FT                   /gene="SHO1"
FT                   /gene_synonym="SSU81"
FT                   /locus_tag="YER118C"
FT                   /product="osmosensor SHO1"
FT                   /note="Transmembrane osmosensor for filamentous growth and
FT                   HOG pathways; involved in activation of the Cdc42p- and MAP
FT                   kinase-dependent filamentous growth pathway and the
FT                   high-osmolarity glycerol (HOG) response pathway;
FT                   phosphorylated by Hog1p; interacts with Pbs2p, Msb2p,
FT                   Hkr1p, and Ste11p"
FT                   /db_xref="GOA:P40073"
FT                   /db_xref="InterPro:IPR001452"
FT                   /db_xref="InterPro:IPR035522"
FT                   /db_xref="InterPro:IPR036028"
FT                   /db_xref="InterPro:IPR039644"
FT                   /db_xref="PDB:2VKN"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40073"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:10980703]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud
FT                   [PMID:10980703]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud
FT                   neck [PMID:10980703|PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043332 mating
FT                   projection tip [PMID:12374868]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:26928762]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007231
FT                   osmosensory signaling pathway [PMID:7624781]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0030010
FT                   establishment of cell polarity [PMID:19439450]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001402 signal
FT                   transduction involved in filamentous growth
FT                   [PMID:18591427|PMID:9744864]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005078
FT                   MAP-kinase scaffold activity [PMID:15200958]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular
FT                   response to heat [PMID:12455951]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005034
FT                   osmosensor activity [PMID:7624781]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005078
FT                   MAP-kinase scaffold activity [PMID:15200958|PMID:16778768]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0007231
FT                   osmosensory signaling pathway [PMID:7624781]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0044697 HICS
FT                   complex [PMID:22623719]"
FT                   /protein_id="DAA07778.1"
FT                   /translation="MSISSKIRPTPRKPSRMATDHSFKMKKFYADPFAISSISLAIVSW
FT                   VIAIGGSISSASTNESFPRFTWWGIVYQFLIICSLMLFYCFDLVDHYRIFITTSIAVAF
FT                   VYNTNSATNLVYADGPKKAAASAGVILLSIINLIWILYYGGDNASPTNRWIDSFSIKGI
FT                   RPSPLENSLHRARRRGNRNTTPYQNNVYNDAIRDSGYATQFDGYPQQQPSHTNYVSSTA
FT                   LAGFENTQPNTSEAVNLHLNTLQQRINSASNAKETNDNSNNQTNTNIGNTFDTDFSNGN
FT                   TETTMGDTLGLYSDIGDDNFIYKAKALYPYDADDDDAYEISFEQNEILQVSDIEGRWWK
FT                   ARRANGETGIIPSNYVQLIDGPEEMHR"
FT   gene            complement(399496..400842)
FT                   /gene="AVT6"
FT                   /locus_tag="YER119C"
FT   mRNA            complement(399496..400842)
FT                   /gene="AVT6"
FT                   /locus_tag="YER119C"
FT                   /product="aspartate/glutamate transporter"
FT   CDS_pept        complement(399496..400842)
FT                   /codon_start=1
FT                   /gene="AVT6"
FT                   /locus_tag="YER119C"
FT                   /product="aspartate/glutamate transporter"
FT                   /note="Vacuolar aspartate and glutamate exporter; member of
FT                   a family of seven genes (AVT1-7) related to vesicular
FT                   GABA-glycine transporters; involved in compartmentalizing
FT                   acidic amino acids in response to nitrogen starvation; AVT6
FT                   has a paralog, AVT5, that arose from the whole genome
FT                   duplication"
FT                   /db_xref="GOA:P40074"
FT                   /db_xref="InterPro:IPR013057"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40074"
FT                   /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
FT                   vacuole [PMID:11274162]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
FT                   vacuole membrane [PMID:20118605|PMID:26928762]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005313
FT                   L-glutamate transmembrane transporter activity
FT                   [PMID:11274162]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015183
FT                   L-aspartate transmembrane transporter activity
FT                   [PMID:11274162]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032974 amino
FT                   acid transmembrane export from vacuole [PMID:11274162]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0055085
FT                   transmembrane transport [PMID:11274162]"
FT                   /protein_id="DAA07779.1"
FT                   /translation="MVASIRSGVLTLLHTACGAGILAMPYAFKPFGLIPGVIMIVLCGA
FT                   CAMQSLFIQARVAKYVPQGRASFSALTRLINPNLGIVFDLAIAIKCFGVGVSYMIVVGD
FT                   LMPQIMSVWTRNAWLLNRNVQISLIMLFFVAPLSFLKKLNSLRYASMVAISSVAYLCVL
FT                   VLLHYVAPSDEILRLKGRISYLLPPQSHDLNVLNTLPIFVFAYTCHHNMFSIINEQRSS
FT                   RFEHVMKIPLIAISLALILYIAIGCAGYLTFGDNIIGNIIMLYPQAVSSTIGRIAIVLL
FT                   VMLAFPLQCHPARASIHQILQHFAEENVSISATSADEPTVATESSPLIRDSSLDLNEVI
FT                   EEESIYQPKETPLRGKSFIVITCSILVASYLVAISVSSLARVLAIVGATGSTSISFILP
FT                   GLFGYKLIGTEHKTAVPLTTKIFKYTGLLLFIWGLIIMITCLTAALKLN"
FT   gene            401135..401869
FT                   /gene="SCS2"
FT                   /locus_tag="YER120W"
FT   mRNA            401135..401869
FT                   /gene="SCS2"
FT                   /locus_tag="YER120W"
FT                   /product="phosphatidylinositol-binding protein SCS2"
FT   CDS_pept        401135..401869
FT                   /codon_start=1
FT                   /gene="SCS2"
FT                   /locus_tag="YER120W"
FT                   /product="phosphatidylinositol-binding protein SCS2"
FT                   /note="Integral ER membrane protein, regulates phospholipid
FT                   metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p,
FT                   Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and
FT                   regulate PI4P levels by controlling access of Sac1p
FT                   phosphatase to substrate PI4P in the PM; interacts with
FT                   FFAT motifs in Opi1p, Swh1p, Osh2p, and Osh3p; involved in
FT                   telomeric silencing; VAP homolog; SCS2 has a paralog,
FT                   SCS22, that arose from the whole genome duplication"
FT                   /db_xref="GOA:P40075"
FT                   /db_xref="InterPro:IPR000535"
FT                   /db_xref="InterPro:IPR008962"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="InterPro:IPR016763"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40075"
FT                   /experiment="EXISTENCE:direct assay:GO:0005635 nuclear
FT                   envelope [PMID:12727870|PMID:25420878]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:12727870|PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:25420878]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud
FT                   tip [PMID:17984322]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030176 integral
FT                   component of endoplasmic reticulum membrane [PMID:9537365]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031965 nuclear
FT                   membrane [PMID:9537365]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035091
FT                   phosphatidylinositol binding [PMID:17963691]"
FT                   /experiment="EXISTENCE:direct assay:GO:0061163 endoplasmic
FT                   reticulum polarization [PMID:25083872]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071561
FT                   nucleus-vacuole junction [PMID:25420878]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006348
FT                   chromatin silencing at telomere
FT                   [PMID:11333225|PMID:12399377]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0008654
FT                   phospholipid biosynthetic process [PMID:8537323]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0048309
FT                   endoplasmic reticulum inheritance [PMID:17984322]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0060304
FT                   regulation of phosphatidylinositol dephosphorylation
FT                   [PMID:23237950]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0090158
FT                   endoplasmic reticulum membrane organization
FT                   [PMID:23237950]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006348
FT                   chromatin silencing at telomere [PMID:11333225]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008654
FT                   phospholipid biosynthetic process
FT                   [PMID:12761300|PMID:9537365]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032377
FT                   regulation of intracellular lipid transport
FT                   [PMID:12727870]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0033149 FFAT
FT                   motif binding [PMID:12727870]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042308 negative
FT                   regulation of protein import into nucleus [PMID:12727870]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0048309
FT                   endoplasmic reticulum inheritance [PMID:17984322]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005935
FT                   cellular bud neck [PMID:25083872]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0033149 FFAT
FT                   motif binding [PMID:12727870]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0042308
FT                   negative regulation of protein import into nucleus
FT                   [PMID:12727870]"
FT                   /protein_id="DAA07780.1"
FT                   /translation="MSAVEISPDVLVYKSPLTEQSTEYASISNNSDQTIAFKVKTTAPK
FT                   FYCVRPNAAVVAPGETIQVQVIFLGLTEEPAADFKCRDKFLVITLPSPYDLNGKAVADV
FT                   WSDLEAEFKQQAISKKIKVKYLISPDVHPAQNQNIQENKETVEPVVQDSEPKEVPAVVN
FT                   EKEVPAEPETQPPVQVKKEEVPPVVQKTVPHENEKQTSNSTPAPQNQIKEAATVPAENE
FT                   SSSMGIFILVALLILVLGWFYR"
FT   gene            402375..402719
FT                   /locus_tag="YER121W"
FT   mRNA            402375..402719
FT                   /locus_tag="YER121W"
FT                   /product="hypothetical protein"
FT   CDS_pept        402375..402719
FT                   /codon_start=1
FT                   /locus_tag="YER121W"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; may be involved in phosphatase
FT                   regulation and/or generation of precursor metabolites and
FT                   energy"
FT                   /db_xref="GOA:P40076"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40076"
FT                   /protein_id="DAA07781.1"
FT                   /translation="MGLSRWHDKNSRPAEEKSEEMQQDAHYYALAASDSLNASVSNEYG
FT                   NQVMNSFWKVGIDSPYVDDEAIRNRDVENNLPSLKQSVYNANEPNATSSAFSTASYAHE
FT                   TFDFRNLKLR"
FT   gene            complement(402871..404352)
FT                   /gene="GLO3"
FT                   /locus_tag="YER122C"
FT   mRNA            complement(402871..404352)
FT                   /gene="GLO3"
FT                   /locus_tag="YER122C"
FT                   /product="ADP-ribosylation factor GTPase-activating
FT                   protein"
FT   CDS_pept        complement(402871..404352)
FT                   /codon_start=1
FT                   /gene="GLO3"
FT                   /locus_tag="YER122C"
FT                   /product="ADP-ribosylation factor GTPase-activating
FT                   protein"
FT                   /note="ADP-ribosylation factor GTPase activating protein
FT                   (ARF GAP); involved in ER-Golgi transport; shares
FT                   functional similarity with Gcs1p"
FT                   /db_xref="GOA:P38682"
FT                   /db_xref="InterPro:IPR001164"
FT                   /db_xref="InterPro:IPR037278"
FT                   /db_xref="InterPro:IPR038508"
FT                   /db_xref="UniProtKB/Swiss-Prot:P38682"
FT                   /experiment="EXISTENCE:direct assay:GO:0005096 GTPase
FT                   activator activity [PMID:9927415]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006890 retrograde
FT                   vesicle-mediated transport, Golgi to endoplasmic reticulum
FT                   [PMID:9927415]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030137 COPI-coated
FT                   vesicle [PMID:15254269]"
FT                   /experiment="EXISTENCE:direct assay:GO:0048205 COPI coating
FT                   of Golgi vesicle [PMID:15254269]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006888
FT                   endoplasmic reticulum to Golgi vesicle-mediated transport
FT                   [PMID:9927415]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006890
FT                   retrograde vesicle-mediated transport, Golgi to endoplasmic
FT                   reticulum [PMID:9927415]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0048205 COPI
FT                   coating of Golgi vesicle [PMID:15254269]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0030126 COPI
FT                   vesicle coat [PMID:15254269]"
FT                   /protein_id="DAA07782.1"
FT                   /translation="MSNDEGETFATEQTTQQVFQKLGSNMENRVCFDCGNKNPTWTSVP
FT                   FGVMLCIQCSAVHRNMGVHITFVKSSTLDKWTINNLRRFKLGGNHKARDFFLKNNGKQL
FT                   LNTANVDAKTKYTSPVAKKYKIHLDKKVQKDMELYPSELVLNGQDSSDSPLDTDSDASR
FT                   STSKENSVDDFFSNWQKPSSNSSSKLNVNTGSLAPKNNTTGSTPKTTVTKTRSSILTAS
FT                   RKKPVLNSQDKKKHSILSSSRKPTRLTAKKVDKSQAEDLFDQFKKEAQQEKEDEFTNSS
FT                   SSTKIRQNDYDSQFMNNSKGNNNNSIDDINTQPDEFNDFLNDTSNSFDTTRKEQQDTLT
FT                   PKFAKLGFGMTMNDANDLAKQQKESQKIAQGPRYTGRIAERYGTQKAISSDQLFGRGSF
FT                   DEAANREAHDKLKTFDNATSISSSSYFGEDKEVDEFGNPINSSGSGAGNFDGRNSNNGF
FT                   IDFNASADDELQMLRDVVEQGAEKLGSYLRDYLRK"
FT   gene            404813..406387
FT                   /gene="YCK3"
FT                   /gene_synonym="CKI3"
FT                   /locus_tag="YER123W"
FT   mRNA            404813..406387
FT                   /gene="YCK3"
FT                   /gene_synonym="CKI3"
FT                   /locus_tag="YER123W"
FT                   /product="casein kinase YCK3"
FT   CDS_pept        404813..406387
FT                   /codon_start=1
FT                   /gene="YCK3"
FT                   /gene_synonym="CKI3"
FT                   /locus_tag="YER123W"
FT                   /product="casein kinase YCK3"
FT                   /EC_number="2.7.11.1"
FT                   /note="Palmitoylated vacuolar membrane-localized casein
FT                   kinase I isoform; negatively regulates vacuole fusion
FT                   during hypertonic stress via phosphorylation of Vps41p;
FT                   shares essential functions with Hrr25p; regulates vesicle
FT                   fusion in AP-3 pathway"
FT                   /db_xref="GOA:P39962"
FT                   /db_xref="InterPro:IPR000719"
FT                   /db_xref="InterPro:IPR008271"
FT                   /db_xref="InterPro:IPR011009"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39962"
FT                   /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type
FT                   vacuole [PMID:16301533]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type
FT                   vacuole membrane
FT                   [PMID:14668479|PMID:24390141|PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004672 protein
FT                   kinase activity [PMID:16319894]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:8816449]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:8816449]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006468 protein
FT                   phosphorylation [PMID:16319894]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016192
FT                   vesicle-mediated transport [PMID:19116312]"
FT                   /protein_id="DAA07783.1"
FT                   /translation="MSQRSSQHIVGIHYAVGPKIGEGSFGVIFEGENILHSCQAQTGSK
FT                   RDSSIIMANEPVAIKFEPRHSDAPQLRDEFRAYRILNGCVGIPHAYYFGQEGMHNILII
FT                   DLLGPSLEDLFEWCGRKFSVKTTCMVAKQMIDRVRAIHDHDLIYRDIKPDNFLISQYQR
FT                   ISPEGKVIKSCASSSNNDPNLIYMVDFGMAKQYRDPRTKQHIPYRERKSLSGTARYMSI
FT                   NTHFGREQSRRDDLESLGHVFFYFLRGSLPWQGLKAPNNKLKYEKIGMTKQKLNPDDLL
FT                   LNNAIPYQFATYLKYARSLKFDEDPDYDYLISLMDDALRLNDLKDDGHYDWMDLNGGKG
FT                   WNIKINRRANLHGYGNPNPRVNGNTARNNVNTNSKTRNTTPVATPKQQAQNSYNKDNSK
FT                   SRISSNPQSFTKQQHVLKKIEPNSKYIPETHSNLQRPIKSQSQTYDSISHTQNSPFVPY
FT                   SSSKANPKRSNNEHNLPNHYTNLANKNINYQSQRNYEQENDAYSDDENDTFCSKIYKYC
FT                   CCCFCCC"
FT   rep_origin      406752..406953
FT                   /note="ARS517; Autonomously Replicating Sequence"
FT   gene            complement(407342..409063)
FT                   /gene="DSE1"
FT                   /locus_tag="YER124C"
FT   mRNA            complement(407342..409063)
FT                   /gene="DSE1"
FT                   /locus_tag="YER124C"
FT                   /product="Dse1p"
FT   CDS_pept        complement(407342..409063)
FT                   /codon_start=1
FT                   /gene="DSE1"
FT                   /locus_tag="YER124C"
FT                   /product="Dse1p"
FT                   /note="Daughter cell-specific protein; may regulate
FT                   cross-talk between the mating and filamentation pathways;
FT                   deletion affects cell separation after division and
FT                   sensitivity to alpha-factor and drugs affecting the cell
FT                   wall; relocalizes from bud neck to cytoplasm upon DNA
FT                   replication stress"
FT                   /db_xref="GOA:P40077"
FT                   /db_xref="InterPro:IPR001680"
FT                   /db_xref="InterPro:IPR036322"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40077"
FT                   /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud
FT                   neck [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031683 G-protein
FT                   beta/gamma-subunit complex binding [PMID:19820940]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum
FT                   digestion after cytokinesis [PMID:11309124]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive
FT                   growth in response to glucose limitation [PMID:19820940]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010969
FT                   regulation of pheromone-dependent signal transduction
FT                   involved in conjugation with cellular fusion
FT                   [PMID:19820940]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031435
FT                   mitogen-activated protein kinase kinase kinase binding
FT                   [PMID:19820940]"
FT                   /protein_id="DAA07784.1"
FT                   /translation="MQDTKYYEPTNIFRQPAINIKKRSDKKRILQSMMTLSTYKKTWQN
FT                   NTSKMNSPILRKASDNFNDYYTTKKLKSDYWKLYGVDESELSIPSDMSIVDNILLVSTM
FT                   NEKDNLKLFEISAEKKLKELQTITVPGKPITCICLLPMVDFPPQIFPSSQINPNHNQLI
FT                   LTGHQDGIVNLIATSTYKGCAKIIKRFNHNKFLKSTVSTSIPILEITPKTAPILKVSPW
FT                   NKTGFVSLLNDSLFIYDLKSNLDCIKTPIFLQSYPGINSFAVNEFHDPFLLALVGSKFG
FT                   PNGISLLDLRTNLYIPDILDNSISAGCGKDHLQRKNTSLDCVWISNHHVAQSLNDKIQI
FT                   WDIQSCDGKPVCELYAKKGYIESLKFNENTGALYSSDDQGFVICWDLQNLQNMKYGELV
FT                   HGFNSISLDSESELLLTKQVFQCGNIIVSGMSDKNICLKSNDTKANGKGCGFLFLDMAN
FT                   DGSLVTLDNFCELGLHQICQVQFNVDTGKIIDGNGTGKSGISDSSMLSLSNESDHSMTE
FT                   TSDDMFSNSGNWDCSSANTVSEGRLNDDQEDIVFTKRMYSVNDVHLSGSTIDTTVV"
FT   gene            410189..412618
FT                   /gene="RSP5"
FT                   /gene_synonym="MDP1"
FT                   /gene_synonym="MUT2"
FT                   /gene_synonym="NPI1"
FT                   /gene_synonym="SMM1"
FT                   /gene_synonym="UBY1"
FT                   /locus_tag="YER125W"
FT   mRNA            410189..412618
FT                   /gene="RSP5"
FT                   /gene_synonym="MDP1"
FT                   /gene_synonym="MUT2"
FT                   /gene_synonym="NPI1"
FT                   /gene_synonym="SMM1"
FT                   /gene_synonym="UBY1"
FT                   /locus_tag="YER125W"
FT                   /product="NEDD4 family E3 ubiquitin-protein ligase"
FT   CDS_pept        410189..412618
FT                   /codon_start=1
FT                   /gene="RSP5"
FT                   /gene_synonym="MDP1"
FT                   /gene_synonym="MUT2"
FT                   /gene_synonym="NPI1"
FT                   /gene_synonym="SMM1"
FT                   /gene_synonym="UBY1"
FT                   /locus_tag="YER125W"
FT                   /product="NEDD4 family E3 ubiquitin-protein ligase"
FT                   /EC_number="2.3.2.26"
FT                   /note="NEDD4 family E3 ubiquitin ligase; regulates
FT                   processes including: MVB sorting, the heat shock response,
FT                   transcription, endocytosis and ribosome stability;
FT                   ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and
FT                   Sem1p; autoubiquitinates; deubiquitinated by Ubp2p;
FT                   regulated by SUMO ligase Siz1p, in turn regulates Siz1p
FT                   SUMO ligase activity; required for efficient Golgi-to-ER
FT                   trafficking in COPI mutants; mutant tolerates aneuploidy;
FT                   human homolog implicated in Liddle syndrome"
FT                   /db_xref="GOA:P39940"
FT                   /db_xref="InterPro:IPR000008"
FT                   /db_xref="InterPro:IPR000569"
FT                   /db_xref="InterPro:IPR001202"
FT                   /db_xref="InterPro:IPR024928"
FT                   /db_xref="InterPro:IPR035892"
FT                   /db_xref="InterPro:IPR035983"
FT                   /db_xref="InterPro:IPR036020"
FT                   /db_xref="PDB:3OLM"
FT                   /db_xref="PDB:4LCD"
FT                   /db_xref="PDB:5HPL"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39940"
FT                   /experiment="EXISTENCE:direct assay:GO:0000209 protein
FT                   polyubiquitination [PMID:9108033]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004842
FT                   ubiquitin-protein transferase activity
FT                   [PMID:21685393|PMID:23443663|PMID:27694912|PMID:9108033]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14608372]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14657247|PMID:15078904]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005794 Golgi
FT                   apparatus [PMID:14657247]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:16622836]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud
FT                   tip [PMID:14608372]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006513 protein
FT                   monoubiquitination [PMID:19176477|PMID:21685393]"
FT                   /experiment="EXISTENCE:direct assay:GO:0010008 endosome
FT                   membrane [PMID:14657247]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016567 protein
FT                   ubiquitination [PMID:23443663]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031234 extrinsic
FT                   component of cytoplasmic side of plasma membrane
FT                   [PMID:15078904]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035091
FT                   phosphatidylinositol binding [PMID:15078904]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin
FT                   binding [PMID:19252184]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006513
FT                   protein monoubiquitination [PMID:14761940|PMID:19176477]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006808
FT                   regulation of nitrogen utilization [PMID:15247235]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007005
FT                   mitochondrion organization [PMID:10366593]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0010794
FT                   regulation of dolichol biosynthetic process
FT                   [PMID:18771750]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0010795
FT                   regulation of ubiquinone biosynthetic process
FT                   [PMID:18771750]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0019220
FT                   regulation of phosphate metabolic process [PMID:18165238]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0032443
FT                   regulation of ergosterol biosynthetic process
FT                   [PMID:18771750]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0032956
FT                   regulation of actin cytoskeleton organization
FT                   [PMID:15855235]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0034517
FT                   ribophagy [PMID:18670191]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0051865
FT                   protein autoubiquitination [PMID:24069405]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein
FT                   polyubiquitination [PMID:9108033]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004842
FT                   ubiquitin-protein transferase activity
FT                   [PMID:21685393|PMID:27694912|PMID:9108033]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006333
FT                   chromatin assembly or disassembly [PMID:12399376]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006511
FT                   ubiquitin-dependent protein catabolic process
FT                   [PMID:25344756|PMID:9614172]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006513 protein
FT                   monoubiquitination
FT                   [PMID:14761940|PMID:19176477|PMID:21685393]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007005
FT                   mitochondrion organization [PMID:10366593]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010793
FT                   regulation of mRNA export from nucleus [PMID:14608372]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010794
FT                   regulation of dolichol biosynthetic process
FT                   [PMID:18771750]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010795
FT                   regulation of ubiquinone biosynthetic process
FT                   [PMID:18771750]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010796
FT                   regulation of multivesicular body size [PMID:17182850]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein
FT                   ubiquitination [PMID:29444958]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+
FT                   mRNA export from nucleus [PMID:27385342]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031384
FT                   regulation of initiation of mating projection growth
FT                   [PMID:21685393]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032436 positive
FT                   regulation of proteasomal ubiquitin-dependent protein
FT                   catabolic process [PMID:24962567]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032443
FT                   regulation of ergosterol biosynthetic process
FT                   [PMID:18771750]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032511 late
FT                   endosome to vacuole transport via multivesicular body
FT                   sorting pathway [PMID:17182849]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032880
FT                   regulation of protein localization [PMID:12867034]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034644 cellular
FT                   response to UV [PMID:10490634]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042493 response
FT                   to drug [PMID:12163175]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043162
FT                   ubiquitin-dependent protein catabolic process via the
FT                   multivesicular body sorting pathway [PMID:17344478]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045723 positive
FT                   regulation of fatty acid biosynthetic process
FT                   [PMID:11007476]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive
FT                   regulation of endocytosis [PMID:12654912]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:11007476]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0048260 positive
FT                   regulation of receptor-mediated endocytosis
FT                   [PMID:11179425]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0070086
FT                   ubiquitin-dependent endocytosis [PMID:17344478]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0072671
FT                   mitochondria-associated ubiquitin-dependent protein
FT                   catabolic process [PMID:21070972]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000203
FT                   regulation of ribosomal large subunit export from nucleus
FT                   [PMID:14608372]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000232
FT                   regulation of rRNA processing [PMID:14608372]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000235
FT                   regulation of tRNA processing [PMID:14608372]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000238
FT                   regulation of tRNA export from nucleus [PMID:14608372]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0000151
FT                   ubiquitin ligase complex [PMID:9931424]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0010793
FT                   regulation of mRNA export from nucleus [PMID:15713680]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0032511 late
FT                   endosome to vacuole transport via multivesicular body
FT                   sorting pathway [PMID:17182849]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0032880
FT                   regulation of protein localization [PMID:12867034]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0042493
FT                   response to drug [PMID:12163175]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0043161
FT                   proteasome-mediated ubiquitin-dependent protein catabolic
FT                   process [PMID:15713680]"
FT                   /protein_id="DAA07785.1"
FT                   /translation="MPSSISVKLVAAESLYKRDVFRSPDPFAVLTIDGYQTKSTSAAKK
FT                   TLNPYWNETFKFDDINENSILTIQVFDQKKFKKKDQGFLGVVNVRVGDVLGHLDEDTAT
FT                   SSGRPREETITRDLKKSNDGMAVSGRLIVVLSKLPSSSPHSQAPSGHTASSSTNTSSTT
FT                   RTNGHSTSSTRNHSTSHPSRGTAQAVESTLQSGTTAATNTATTSHRSTNSTSSATRQYS
FT                   SFEDQYGRLPPGWERRTDNFGRTYYVDHNTRTTTWKRPTLDQTEAERGNQLNANTELER
FT                   RQHRGRTLPGGSSDNSSVTVQVGGGSNIPPVNGAAAAAFAATGGTTSGLGELPSGWEQR
FT                   FTPEGRAYFVDHNTRTTTWVDPRRQQYIRTYGPTNTTIQQQPVSQLGPLPSGWEMRLTN
FT                   TARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKVIYFRSQPALRILPGQCHIK
FT                   VRRKNIFEDAYQEIMRQTPEDLKKRLMIKFDGEEGLDYGGVSREFFFLLSHEMFNPFYC
FT                   LFEYSAYDNYTIQINPNSGINPEHLNYFKFIGRVVGLGVFHRRFLDAFFVGALYKMMLR
FT                   KKVVLQDMEGVDAEVYNSLNWMLENSIDGVLDLTFSADDERFGEVVTVDLKPDGRNIEV
FT                   TDGNKKEYVELYTQWRIVDRVQEQFKAFMDGFNELIPEDLVTVFDERELELLIGGIAEI
FT                   DIEDWKKHTDYRGYQESDEVIQWFWKCVSEWDNEQRARLLQFTTGTSRIPVNGFKDLQG
FT                   SDGPRRFTIEKAGEVQQLPKSHTCFNRVDLPQYVDYDSMKQKLTLAVEETIGFGQE"
FT   gene            complement(413394..414179)
FT                   /gene="NSA2"
FT                   /locus_tag="YER126C"
FT   mRNA            complement(413394..414179)
FT                   /gene="NSA2"
FT                   /locus_tag="YER126C"
FT                   /product="rRNA-processing protein NSA2"
FT   CDS_pept        complement(413394..414179)
FT                   /codon_start=1
FT                   /gene="NSA2"
FT                   /locus_tag="YER126C"
FT                   /product="rRNA-processing protein NSA2"
FT                   /note="Protein constituent of 66S pre-ribosomal particles;
FT                   contributes to processing of the 27S pre-rRNA; recruited by
FT                   ribosomal proteins L17, L35, and L37 to assembling
FT                   ribosomes after 27SB pre-rRNA is generated, immediately
FT                   preceding removal of ITS2"
FT                   /db_xref="GOA:P40078"
FT                   /db_xref="InterPro:IPR022309"
FT                   /db_xref="InterPro:IPR039411"
FT                   /db_xref="PDB:3JCT"
FT                   /db_xref="PDB:4WJV"
FT                   /db_xref="PDB:6ELZ"
FT                   /db_xref="PDB:6EM1"
FT                   /db_xref="PDB:6EM5"
FT                   /db_xref="PDB:6FT6"
FT                   /db_xref="PDB:6N8J"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40078"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:10684247]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030687 preribosome,
FT                   large subunit precursor
FT                   [PMID:11583614|PMID:16861225|PMID:17443350]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000463
FT                   maturation of LSU-rRNA from tricistronic rRNA transcript
FT                   (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16861225]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000466
FT                   maturation of 5.8S rRNA from tricistronic rRNA transcript
FT                   (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16861225]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042273
FT                   ribosomal large subunit biogenesis [PMID:11583614]"
FT                   /protein_id="DAA07786.1"
FT                   /translation="MPQNDYIERHIKQHGKRLDHEERKRKREARESHKISERAQKLTGW
FT                   KGKQFAKKRYAEKVSMRKKIKAHEQSKVKGSSKPLDTDGDALPTYLLDREQNNTAKAIS
FT                   SSIKQKRLEKADKFSVPLPKVRGISEEEMFKVIKTGKSRSKSWKRMITKHTFVGEGFTR
FT                   RPVKMERIIRPSALRQKKANVTHPELGVTVFLPILAVKKNPQSPMYTQLGVLTKGTIIE
FT                   VNVSELGMVTAGGKVVWGKYAQVTNEPDRDGCVNAVLLV"
FT   gene            414481..415554
FT                   /gene="LCP5"
FT                   /locus_tag="YER127W"
FT   mRNA            414481..415554
FT                   /gene="LCP5"
FT                   /locus_tag="YER127W"
FT                   /product="Lcp5p"
FT   CDS_pept        414481..415554
FT                   /codon_start=1
FT                   /gene="LCP5"
FT                   /locus_tag="YER127W"
FT                   /product="Lcp5p"
FT                   /note="Essential protein involved in maturation of 18S
FT                   rRNA; depletion leads to inhibited pre-rRNA processing and
FT                   reduced polysome levels; localizes primarily to the
FT                   nucleolus"
FT                   /db_xref="GOA:P40079"
FT                   /db_xref="InterPro:IPR007146"
FT                   /db_xref="PDB:5WLC"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40079"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:9814757]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000447
FT                   endonucleolytic cleavage in ITS1 to separate SSU-rRNA from
FT                   5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript
FT                   (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9814757]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000480
FT                   endonucleolytic cleavage in 5'-ETS of tricistronic rRNA
FT                   transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9814757]"
FT                   /protein_id="DAA07787.1"
FT                   /translation="MSELNALLKDINGSLTATSESLERLSGIYSNSATDEIPESNQLHE
FT                   HLFYDAKKPAEKVSLLSLKNGSMLGYINSLLMLIGNRLDDECKDPSAMDARERSIQHRV
FT                   VLERGVKPLEKKLAYQLDKLTRAYVKMEKEYKDAEKRALEKSTLVNHSGNDDSEDDESS
FT                   EDEIAYRPNTSGIINTNKKSSAYRVEETAKQENGEENDDNETGVYKPPKITAVLPPQQT
FT                   HFEDRFDAREHKDRSNKSRMQAMEEYIRESSDQPDWSASIGADIVNHGRGGIKSLRDTE
FT                   KERRVTSFEEDNFTRLNITNKAEKRKQKQRERNARMNVIGGEDFGIFSSKRKLEDSTSR
FT                   RGAKKTRSAWDRAQRRL"
FT   gene            415859..416470
FT                   /gene="VFA1"
FT                   /locus_tag="YER128W"
FT   mRNA            415859..416470
FT                   /gene="VFA1"
FT                   /locus_tag="YER128W"
FT                   /product="Vfa1p"
FT   CDS_pept        415859..416470
FT                   /codon_start=1
FT                   /gene="VFA1"
FT                   /locus_tag="YER128W"
FT                   /product="Vfa1p"
FT                   /note="Protein that interacts with Vps4p and has a role in
FT                   vacuolar sorting; stimulates the ATPase activity of Vps4;
FT                   localizes to endosomes in a Vps4-dependent manner;
FT                   overexpression causes canavanine sensitivity and confers a
FT                   partial class D vacuole morphology"
FT                   /db_xref="GOA:P40080"
FT                   /db_xref="InterPro:IPR013640"
FT                   /db_xref="PDB:4NIQ"
FT                   /db_xref="PDB:5FVK"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40080"
FT                   /experiment="EXISTENCE:direct assay:GO:0001671 ATPase
FT                   activator activity [PMID:24567329]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:21777356]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005768 endosome
FT                   [PMID:21777356]"
FT                   /experiment="EXISTENCE:direct assay:GO:0032781 positive
FT                   regulation of ATPase activity [PMID:24567329]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar
FT                   transport [PMID:21777356]"
FT                   /protein_id="DAA07788.1"
FT                   /translation="MINEYVARKVALKDMQPCAICSKPSTTVLYNASGPDWLYTCEIHL
FT                   QDNPQFVIPLYSTEYNEAVAQLKLVKGKMDSLTSAQTQLGSWDGWVTKIFSKKEKETNN
FT                   SKDPDPTTTDSTDTSPQAKNDAEILSETKKQYSKILDKVTELQRKNRKYELAKIMFESR
FT                   LLRKRTEQVNRERYLKEQENYSNTDPEELLRKHVFPSVPK"
FT   gene            417281..420709
FT                   /gene="SAK1"
FT                   /gene_synonym="PAK1"
FT                   /locus_tag="YER129W"
FT   mRNA            417281..420709
FT                   /gene="SAK1"
FT                   /gene_synonym="PAK1"
FT                   /locus_tag="YER129W"
FT                   /product="serine/threonine protein kinase SAK1"
FT   CDS_pept        417281..420709
FT                   /codon_start=1
FT                   /gene="SAK1"
FT                   /gene_synonym="PAK1"
FT                   /locus_tag="YER129W"
FT                   /product="serine/threonine protein kinase SAK1"
FT                   /EC_number="2.7.11.1"
FT                   /note="Upstream serine/threonine kinase for the SNF1
FT                   complex; plays a role in pseudohyphal groth; partially
FT                   redundant with Elm1p and Tos3p; members of this family have
FT                   functional orthology with LKB1, a mammalian kinase
FT                   associated with Peutz-Jeghers cancer-susceptibility
FT                   syndrome; SAK1 has a paralog, TOS3, that arose from the
FT                   whole genome duplication"
FT                   /db_xref="GOA:P38990"
FT                   /db_xref="InterPro:IPR000719"
FT                   /db_xref="InterPro:IPR008271"
FT                   /db_xref="InterPro:IPR011009"
FT                   /db_xref="InterPro:IPR017441"
FT                   /db_xref="UniProtKB/Swiss-Prot:P38990"
FT                   /experiment="EXISTENCE:direct assay:GO:0004672 protein
FT                   kinase activity [PMID:16319894]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004674 protein
FT                   serine/threonine kinase activity
FT                   [PMID:12748292|PMID:12847291|PMID:16201971|PMID:27524664]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:22289182|PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006468 protein
FT                   phosphorylation
FT                   [PMID:12748292|PMID:12847291|PMID:16201971|PMID:9341678|PM
FT                   ID:16319894]"
FT                   /experiment="EXISTENCE:direct assay:GO:0018107
FT                   peptidyl-threonine phosphorylation [PMID:27524664]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006468
FT                   protein phosphorylation [PMID:12847291]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0090329
FT                   regulation of DNA-dependent DNA replication [PMID:9341678]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein
FT                   serine/threonine kinase activity
FT                   [PMID:12748292|PMID:16201971]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0005979
FT                   regulation of glycogen biosynthetic process
FT                   [PMID:15340085]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006468 protein
FT                   phosphorylation [PMID:12748292|PMID:16201971]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1900180
FT                   regulation of protein localization to nucleus
FT                   [PMID:15340085]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000220
FT                   regulation of pseudohyphal growth [PMID:19880754]"
FT                   /protein_id="DAA07789.1"
FT                   /translation="MDRSDKKVNVEEVNVPSNLQIELEKSGTSSSVSLRSPTKSSATNL
FT                   AGMAEGARDNASIASSSVDSLNMLLERQRVRQLNHPQHQQHISSSLAKTPTTTSSFCSS
FT                   GSSKNKVKETNRISLTYDPVSKRKVLNTYEIIKELGHGQHGKVKLARDILSKQLVAIKI
FT                   VDRHEKKQRKFFTFIKSSKISENDKIKREIAIMKKCHHKHVVQLIEVLDDLKSRKIYLV
FT                   LEYCSRGEVKWCPPDCMESDAKGPSLLSFQETREILRGVVLGLEYLHYQGIIHRDIKPA
FT                   NLLISGDGTVKISDFGVSLAASSTNSSDSSESLDELELAKTVGTPAFFAPEMCLGEDAF
FT                   TRYNLTKENLFRGSCISFMIDIWAVGVTLYCLLFGMLPFFSDFELKLFEKIVNDPLKFP
FT                   TFKEIQSNKVSKVSCEEEYEMAKDLLLKLLEKNPQKRMTIPAIKKHPFVSWDFDHVPEN
FT                   DEKLLSSVLEQKLRFQCNQTDQFEPISISKHELKNAVSGVGKKIKESVLKSIPLKDPSD
FT                   LSNKNYLHPTETTRGRGDANVIVSEGSVLSNIKELSANDGCLNTDSDTNININDDDHYS
FT                   GDDNDGHLTKRELERELNKFDDKHEAGNMVNLPINSSFASLDSFYIDNFAMARMGMSSP
FT                   EAGDSVSSVPNLPSAPSSTRLGRSPVFSGVTNQPSPIRPVLPQQKSSFCATGRYDKSHN
FT                   SLLRNSSSHLTSYNSGRPSSRTGRMNSRNQNLPKIPNSLSKISTTKLTELRVPKDSEIP
FT                   SPAKNPNADRLRRFPVKKNTKTPAIKDPPRININSSDKSGSKNSPIKSLYQRMKQSKDN
FT                   SKTFEVRRGNFFSHFNGDDDDSSSQSSVTSSGSESDSELSSTSSSCTSGTQSRNSSNNN
FT                   AYSETESLPFEFGVDSEDGSGVLLRDLPNEDQIRPFLDIQPCRRMKVKSSLNLEPPSVS
FT                   SSSSSSSDEDELILNVGTAGHRRRHNSSKLSELSNSPQKGSNNFMYSNGSVHDSETTIT
FT                   PQNMDDLTLHQALSRSQPISKPGPLVLPKRLDQKKATTETSNLTDIVEFNGNNDHRKDK
FT                   NFDKVLYSRDLLKDALSSTNAGRRRSIPSNKIRGRKDASITMSTNVGNDEHARNTSCHG
FT                   DKGQENGAIKQRTHERSRSLTVAELNEEKRRSALP"
FT   gene            complement(421115..422446)
FT                   /gene="COM2"
FT                   /locus_tag="YER130C"
FT   mRNA            complement(421115..422446)
FT                   /gene="COM2"
FT                   /locus_tag="YER130C"
FT                   /product="Com2p"
FT   CDS_pept        complement(421115..422446)
FT                   /codon_start=1
FT                   /gene="COM2"
FT                   /locus_tag="YER130C"
FT                   /product="Com2p"
FT                   /note="Transcription factor that binds IME1 Upstream
FT                   Activation Signal (UAS)ru; COM2 transcription is regulated
FT                   by Haa1p, Sok2p and Zap1p transcriptional activators; may
FT                   bind the IME1 promoter under all growth conditions to
FT                   negatively regulate its transcription in the absence of a
FT                   positive regulator that binds more effectively; repressor
FT                   activity may depend on phosphorylation by PKA; C. albicans
FT                   homolog (MNL1) plays a role in adaptation to stress"
FT                   /db_xref="GOA:P39959"
FT                   /db_xref="InterPro:IPR013087"
FT                   /db_xref="InterPro:IPR036236"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39959"
FT                   /protein_id="DAA07790.1"
FT                   /translation="MSLYPLQRFESNDTVFSYTLNSKTELFNESRNNDKQHFTLQLIPN
FT                   ANANAKEIDNNNVEIINDLTGNTIVDNCVTTATSSNQLERRLSISDYRTENGNYYEYEF
FT                   FGRRELNEPLFNNDIVENDDDIDLNNESDVLMVSDDELEVNERFSFLKQQPLDGLNRIS
FT                   STNNLKNLEIHEFIIDPTENIDDELEDSFTTVPQSKKKVRDYFKLNIFGSSSSSNNNSN
FT                   SLGCEPIQTENSSSQKMFKNRFFRSRKSTLIKSLPLEQENEVLINSGFDVSSNEESDES
FT                   DHAIINPLKLVGNNKDISTQSIAKTTNPFKSGSDFKMIEPVSKFSNDSRKDLLAAISEP
FT                   SSSPSPSAPSPSVQSSSSSHGLVVRKKTGSMQKTRGRKPSLIPDASKQFGCEFCDRRFK
FT                   RQEHLKRHVRSLHMCEKPFTCHICNKNFSRSDNLNQHVKTHASL"
FT   gene            423952..424311
FT                   /gene="RPS26B"
FT                   /locus_tag="YER131W"
FT   mRNA            423952..424311
FT                   /gene="RPS26B"
FT                   /locus_tag="YER131W"
FT                   /product="ribosomal 40S subunit protein S26B"
FT   CDS_pept        423952..424311
FT                   /codon_start=1
FT                   /gene="RPS26B"
FT                   /locus_tag="YER131W"
FT                   /product="ribosomal 40S subunit protein S26B"
FT                   /note="Protein component of the small (40S) ribosomal
FT                   subunit; homologous to mammalian ribosomal protein S26, no
FT                   bacterial homolog; RPS26B has a paralog, RPS26A, that arose
FT                   from the whole genome duplication; human homolog can
FT                   partially complement an RPS26A, RPS26B double null mutant;
FT                   mutations in the human gene are associated with
FT                   Diamond-Blackfan anemia"
FT                   /db_xref="GOA:P39939"
FT                   /db_xref="InterPro:IPR000892"
FT                   /db_xref="InterPro:IPR038551"
FT                   /db_xref="PDB:4U3M"
FT                   /db_xref="PDB:4U3N"
FT                   /db_xref="PDB:4U3U"
FT                   /db_xref="PDB:4U4N"
FT                   /db_xref="PDB:4U4O"
FT                   /db_xref="PDB:4U4Q"
FT                   /db_xref="PDB:4U4R"
FT                   /db_xref="PDB:4U4U"
FT                   /db_xref="PDB:4U4Y"
FT                   /db_xref="PDB:4U4Z"
FT                   /db_xref="PDB:4U50"
FT                   /db_xref="PDB:4U51"
FT                   /db_xref="PDB:4U52"
FT                   /db_xref="PDB:4U53"
FT                   /db_xref="PDB:4U55"
FT                   /db_xref="PDB:4U56"
FT                   /db_xref="PDB:4U6F"
FT                   /db_xref="PDB:5DAT"
FT                   /db_xref="PDB:5DC3"
FT                   /db_xref="PDB:5DGF"
FT                   /db_xref="PDB:5DGV"
FT                   /db_xref="PDB:5FCJ"
FT                   /db_xref="PDB:5I4L"
FT                   /db_xref="PDB:5LYB"
FT                   /db_xref="PDB:5M1J"
FT                   /db_xref="PDB:5MEI"
FT                   /db_xref="PDB:5NDG"
FT                   /db_xref="PDB:5NDV"
FT                   /db_xref="PDB:5NDW"
FT                   /db_xref="PDB:5OBM"
FT                   /db_xref="PDB:5ON6"
FT                   /db_xref="PDB:5TBW"
FT                   /db_xref="PDB:5TGA"
FT                   /db_xref="PDB:5TGM"
FT                   /db_xref="PDB:6GQ1"
FT                   /db_xref="PDB:6GQB"
FT                   /db_xref="PDB:6GQV"
FT                   /db_xref="PDB:6HHQ"
FT                   /db_xref="PDB:6I7O"
FT                   /db_xref="PDB:6Q8Y"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39939"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006407 rRNA
FT                   export from nucleus [PMID:16246728]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042255 ribosome
FT                   assembly [PMID:27303706]"
FT                   /protein_id="DAA07791.1"
FT                   /translation="MPKKRASNGRNKKGRGHVKPVRCVNCSKSIPKDKAIKRMAIRNIV
FT                   EAAAVRDLSEASVYPEYALPKTYNKLHYCVSCAIHARIVRVRSREDRKNRAPPQRPRFN
FT                   RDNKVSPAAAAKKAL"
FT   gene            424698..424883
FT                   /locus_tag="snR4"
FT   ncRNA           424698..424883
FT                   /locus_tag="snR4"
FT                   /product="SNR4"
FT                   /note="C/D box small nucleolar RNA (snoRNA) but not shown
FT                   to be active; no target site is predicted within the
FT                   ribosomal RNAs"
FT                   /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
FT                   [PMID:3327689]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:3327689]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031428 box C/D
FT                   snoRNP complex [PMID:10094313]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070181 small
FT                   ribosomal subunit rRNA binding [PMID:28542199]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1990882 rRNA
FT                   acetylation [PMID:28542199]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031428 box
FT                   C/D snoRNP complex [PMID:10733567|PMID:11081632]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0042134 rRNA
FT                   primary transcript binding [PMID:3327689]"
FT                   /ncRNA_class="snoRNA"
FT   gene            complement(425188..430449)
FT                   /gene="PMD1"
FT                   /locus_tag="YER132C"
FT   mRNA            complement(425188..430449)
FT                   /gene="PMD1"
FT                   /locus_tag="YER132C"
FT                   /product="Pmd1p"
FT   CDS_pept        complement(425188..430449)
FT                   /codon_start=1
FT                   /gene="PMD1"
FT                   /locus_tag="YER132C"
FT                   /product="Pmd1p"
FT                   /note="Protein with an N-terminal kelch-like domain;
FT                   putative negative regulator of early meiotic gene
FT                   expression; required, with Mds3p, for growth under alkaline
FT                   conditions; PMD1 has a paralog, MDS3, that arose from the
FT                   whole genome duplication"
FT                   /db_xref="GOA:P32634"
FT                   /db_xref="InterPro:IPR015915"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32634"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0030437
FT                   ascospore formation [PMID:9383076]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030437
FT                   ascospore formation [PMID:9383076]"
FT                   /protein_id="DAA07792.1"
FT                   /translation="MTVLQPPSSVCYPLNLPIVPNPNLDEATRKKLTLECRTGAAVELA
FT                   RSGVFVHGGLTLPLNLTIINSLQLQKELILYFGKQKDRNADFKTLADWISPEIFFLDLI
FT                   SRTWQRINTTIDTTSENELNNGLSFKERLFHSMCFTESNIYIFGGLMVSPHNGYELIAT
FT                   NELWKLDLKTKCWSLISENPQITRRFNHSMHVLNENNENQDTKLIIVGGLDNMDIPVKK
FT                   IDIFNLRTSLWESESKSDENPASKGSSKILVNIDGMPISLSHDSNFSVLIENNQAEIPT
FT                   LALYYPQREANTSRRGTDDGSFSTYAHDLDDKSKLPKHHHHHHGDLKYFESDDADENAV
FT                   KTLMSPIVILPLLGNSQGARMTSNPTQNNKENSILQVPFHLQYPSGNYFNYNIVVIGFY
FT                   PDPQPSNLHCFIYNIASGKWIRVNIACTECSISMHRFWKLLIWKSHHQALLLGTRTDDF
FT                   CSPSVQKFDHILSFSLPMLNGYNKLVNTKHTRTNNGIANSHNLNVNLSLYDHLPYSNSS
FT                   TIEHTNPYTVTQGYSLDDSGIPRLTSTATSQFENYSRYITVPLEMESTSSIFPPYAMVL
FT                   GKDALEIFGKTLSDFEFITADGDSIGVPVYLLRKRWGRYFDSLLSNGYANTSFNYEFNG
FT                   DTSNIISFSPHTASKTTKFGNSSQSSNGSLEKYFSKNGNSKSNSNTSLKKPHSVDFTSS
FT                   TSSPKQRAISHNKLSPSEPILCADEEDSRSNTLKQHATGDTGLKETGTSNKRPISTTCS
FT                   STGMVFRVPFQDMKNSKLGLSEQSGRSTRASSVSPPPVYKKSTNDGNDSNCTLSNTPLV
FT                   YRRASTVGTTTNSSVDDGFSSIRRASHPLQSYIIAKSSPSSISKASPAEKAFSRRKSSA
FT                   LRFIASPNQSRQTSFASTASTASVVSSTSGRRRNSNQISHLGSSASLPNSPILPVLNIP
FT                   LPPQEKIPLEPLPPVPKAPSRRSSSLAEYVQFGRDSPVASRRSSHSTRKSSSSDARRIS
FT                   NSSLLRNTLDSQLLSNSYGSDIPYEASIQEYGMNNGRDEEEDGDNQDYGCISPSNIRPI
FT                   FSTINAININGNFKEGEFFSSKSYINNEKSRRLSYISNPESVESTNSNNNAIIELEPLL
FT                   TPRSLYMPWSTASVRAFAEFFYTAQINGKWLLAPVTLDLLIMAKIYEIPILYELITEVL
FT                   YKIISKKEEGLSVTCEALLNLFQQKVSRYCNENEGKIRKQLDSSESYQDTLEIKRSLAN
FT                   IDNGYVDSYLLRNTSMAQSIHYTDDSNGETEIDMHHTGISSIGSLANRAVPTVFAGGPR
FT                   DSHNSIGSIAFPSNSGVQNIRRSVSLFSPATKKKSSLSRETDPLDTSDQFTDDVPDSGP
FT                   VSRQQNFPRRSSSFTETVPTEPTRYNYQNLDSSKSNRASDDKEEQNEQATLQDISNFDK
FT                   YKVETLQKRNSNDGKDLDRTNDPLKNRGTEIPQNSSNLETDPFIRDSFDSDSGSSFRSD
FT                   SDDLDSQLGILPFTKMNKKLQEQTSQEFDDSIDPLYKIGSSTPGSSRLHGSFSKYIRPN
FT                   SQREDGSEYVNISSLENMVSPNALPPVDYVMKSIYRTSVLVNDSNLMTRTKEAIELSKV
FT                   LKKLKKKVLQDISQMDDEMRETGKPIFARGSSSPTLSRQHSDVATPLKQQENTRPALKF
FT                   ASSSPISEGFRKSSIKFSQAPSTQISPRTSVTDFTASQQRRQHMNKRFSTQTTHSTSAL
FT                   FMNPAFMPSAVNTGRKESEGHCEDRSATANRTNRKEDATTNDNDNIAPFPFFGKRR"
FT   gene            complement(431129..431220)
FT                   /locus_tag="snR52"
FT   ncRNA           complement(431129..431220)
FT                   /locus_tag="snR52"
FT                   /product="SNR52"
FT                   /note="C/D box small nucleolar RNA (snoRNA); guides
FT                   2'-O-methylation of large subunit (LSU) rRNA at position
FT                   U2921 and small subunit (SSU) rRNA at position A420"
FT                   /experiment="EXISTENCE:curator inference:GO:0005730
FT                   nucleolus [PMID:10024243]"
FT                   /experiment="EXISTENCE:curator inference:GO:0031428 box C/D
FT                   snoRNP complex [PMID:10024243]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0030562 rRNA
FT                   2'-O-ribose methylation guide activity [PMID:15546625]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0031167 rRNA
FT                   methylation [PMID:15546625]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030562 rRNA
FT                   2'-O-ribose methylation guide activity
FT                   [PMID:10024243|PMID:15546625]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA
FT                   methylation [PMID:10024243|PMID:15546625]"
FT                   /ncRNA_class="snoRNA"
FT   repeat_region   complement(431490..431822)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            432495..433958
FT                   /gene="GLC7"
FT                   /gene_synonym="CID1"
FT                   /gene_synonym="DIS2"
FT                   /locus_tag="YER133W"
FT   mRNA            join(432495..432671,433197..433958)
FT                   /gene="GLC7"
FT                   /gene_synonym="CID1"
FT                   /gene_synonym="DIS2"
FT                   /locus_tag="YER133W"
FT                   /product="type 1 serine/threonine-protein phosphatase
FT                   catalytic subunit GLC7"
FT   CDS_pept        join(432495..432671,433197..433958)
FT                   /codon_start=1
FT                   /gene="GLC7"
FT                   /gene_synonym="CID1"
FT                   /gene_synonym="DIS2"
FT                   /locus_tag="YER133W"
FT                   /product="type 1 serine/threonine-protein phosphatase
FT                   catalytic subunit GLC7"
FT                   /EC_number="3.1.3.16"
FT                   /note="Type 1 S/T protein phosphatase (PP1) catalytic
FT                   subunit; involved in glycogen metabolism, sporulation and
FT                   mitotic progression; interacts with multiple regulatory
FT                   subunits; regulates actomyosin ring formation; subunit of
FT                   CPF; recruited to mating projections by Afr1p interaction;
FT                   regulates nucleocytoplasmic shuttling of Hxk2p; import into
FT                   the nucleus is inhibited during spindle assembly checkpoint
FT                   arrest; involved in dephosphorylating Rps6a/b and Bnr1p"
FT                   /db_xref="GOA:P32598"
FT                   /db_xref="InterPro:IPR004843"
FT                   /db_xref="InterPro:IPR006186"
FT                   /db_xref="InterPro:IPR029052"
FT                   /db_xref="InterPro:IPR031675"
FT                   /db_xref="InterPro:IPR037981"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32598"
FT                   /experiment="EXISTENCE:direct assay:GO:0000164 protein
FT                   phosphatase type 1 complex [PMID:8289829]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000778 condensed
FT                   nuclear chromosome kinetochore [PMID:19948764]"
FT                   /experiment="EXISTENCE:direct assay:GO:0001400 mating
FT                   projection base [PMID:10747092]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004722 protein
FT                   serine/threonine phosphatase activity [PMID:1660885]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:23418575]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:11412094]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole
FT                   body [PMID:10747092]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005847 mRNA
FT                   cleavage and polyadenylation specificity factor complex
FT                   [PMID:12819204]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud
FT                   neck [PMID:11412094]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006470 protein
FT                   dephosphorylation [PMID:1660885]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016576 histone
FT                   dephosphorylation [PMID:19884341]"
FT                   /experiment="EXISTENCE:direct assay:GO:0032153 cell
FT                   division site [PMID:26771880]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070940
FT                   dephosphorylation of RNA polymerase II C-terminal domain
FT                   [PMID:24413056]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000076 DNA
FT                   replication checkpoint [PMID:19884341]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000723
FT                   telomere maintenance [PMID:29529242]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0008360
FT                   regulation of cell shape [PMID:12477789]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:2000370
FT                   positive regulation of clathrin-dependent endocytosis
FT                   [PMID:12356757]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000076 DNA
FT                   replication checkpoint [PMID:19884341]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA
FT                   damage checkpoint [PMID:19884341]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006470 protein
FT                   dephosphorylation [PMID:26582391|PMID:26771880]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006873 cellular
FT                   ion homeostasis [PMID:11973298]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006986 response
FT                   to unfolded protein [PMID:25730376]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007059
FT                   chromosome segregation [PMID:10072383]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic
FT                   spindle assembly checkpoint [PMID:10072380]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007116
FT                   regulation of cell budding [PMID:10639337]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007346
FT                   regulation of mitotic cell cycle [PMID:23418575]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009408 response
FT                   to heat [PMID:10207049]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016576 histone
FT                   dephosphorylation [PMID:10975519|PMID:19884341]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030437
FT                   ascospore formation [PMID:9584086]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031297
FT                   replication fork processing [PMID:19884341]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein
FT                   localization to kinetochore [PMID:19948764]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0035307 positive
FT                   regulation of protein dephosphorylation [PMID:23418575]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051726
FT                   regulation of cell cycle
FT                   [PMID:10072380|PMID:7891699|PMID:8164671|PMID:9584086]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0061587 transfer
FT                   RNA gene-mediated silencing [PMID:23707796]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0070873
FT                   regulation of glycogen metabolic process [PMID:1660885]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1901901
FT                   regulation of protein localization to cell division site
FT                   involved in cytokinesis [PMID:26771880]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1903501 positive
FT                   regulation of mitotic actomyosin contractile ring assembly
FT                   [PMID:26771880]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0000164
FT                   protein phosphatase type 1 complex [PMID:19948764]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0051321
FT                   meiotic cell cycle [PMID:8754819]"
FT                   /protein_id="DAA07793.1"
FT                   /translation="MDSQPVDVDNIIDRLLEVRGSKPGQQVDLEENEIRYLCSKARSIF
FT                   IKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
FT                   LLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAI
FT                   IDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGV
FT                   SFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAM
FT                   MSVDESLLCSFQILKPAQKSLPRQAGGRKKK"
FT   gene            complement(434541..434612)
FT                   /locus_tag="tH(GUG)E2"
FT   tRNA            complement(434541..434612)
FT                   /locus_tag="tH(GUG)E2"
FT                   /product="tRNA-His"
FT                   /note="tH(GUG)E2; Histidine tRNA (tRNA-His), predicted by
FT                   tRNAscan-SE analysis"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030371 translation
FT                   repressor activity [PMID:27609601]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043022 ribosome
FT                   binding [PMID:27609601]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043555 regulation
FT                   of translation in response to stress [PMID:27609601]"
FT   repeat_region   complement(434631..434971)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty3 LTR"
FT   repeat_region   complement(435128..435447)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            complement(435752..435824)
FT                   /locus_tag="tK(CUU)E2"
FT   tRNA            complement(435752..435824)
FT                   /locus_tag="tK(CUU)E2"
FT                   /product="tRNA-Lys"
FT                   /note="tK(CUU)E2; Lysine tRNA (tRNA-Lys), predicted by
FT                   tRNAscan-SE analysis; a small portion is imported into
FT                   mitochondria via interaction with mt lysyl-tRNA synthetase
FT                   Msk1p and is necessary to decode AAG codons at high
FT                   temperature, when base modification of mt-encoded tRNA-Lys
FT                   is reduced"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:8915539]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:8915539]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030533 triplet
FT                   codon-amino acid adaptor activity [PMID:17560369]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032543
FT                   mitochondrial translation [PMID:17560369]"
FT   repeat_region   complement(435946..436277)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   repeat_region   complement(436279..436605)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty4 LTR"
FT   gene            complement(437267..437803)
FT                   /locus_tag="YER134C"
FT   mRNA            complement(437267..437803)
FT                   /locus_tag="YER134C"
FT                   /product="Mg-dependent acid phosphatase"
FT   CDS_pept        complement(437267..437803)
FT                   /codon_start=1
FT                   /locus_tag="YER134C"
FT                   /product="Mg-dependent acid phosphatase"
FT                   /EC_number="3.1.3.48"
FT                   /note="Magnesium-dependent acid phosphatase; member of the
FT                   haloacid dehalogenase superfamily; non-essential gene"
FT                   /db_xref="GOA:P40081"
FT                   /db_xref="InterPro:IPR010033"
FT                   /db_xref="InterPro:IPR010036"
FT                   /db_xref="InterPro:IPR023214"
FT                   /db_xref="InterPro:IPR035679"
FT                   /db_xref="InterPro:IPR036412"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40081"
FT                   /experiment="EXISTENCE:direct assay:GO:0003993 acid
FT                   phosphatase activity [PMID:11601995]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030946 protein
FT                   tyrosine phosphatase activity, metal-dependent
FT                   [PMID:11601995]"
FT                   /protein_id="DAA07794.1"
FT                   /translation="MTGYPDVAAFDLDYTIWPCYCDTHLHGPFKPVKSSNGEVLTIICR
FT                   DGYELTIYKDIPRILGDLKDNGVKLMTASRTWAPEIAQEILKIFKVKYAGVVTPLANLF
FT                   DEFQWGERSKIGHLRDGLKDLYNTSDLKSKKICLFDDESRNKEVEKYGVKFVYVRDPEN
FT                   GPSWKLYQDYLSGKV"
FT   gene            complement(437952..438344)
FT                   /locus_tag="YER135C"
FT   mRNA            complement(437952..438344)
FT                   /locus_tag="YER135C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(437952..438344)
FT                   /codon_start=1
FT                   /locus_tag="YER135C"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; conserved among S. cerevisiae
FT                   strains; YER135C is not an essential gene"
FT                   /db_xref="GOA:P40082"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40082"
FT                   /protein_id="DAA80288.1"
FT                   /translation="MTWTLRNLHNSQKKVLVDITIWLALSPYGDMALFTSFENIIGEYY
FT                   RYSILPLHQNLHKLLFTLFLICLASWKEGNRSCRYKWQKFVCNKLNSPETNFVPIRTSV
FT                   NKNSKMIVEKQISIHISLKCIVYKEY"
FT   gene            438700..438773
FT                   /locus_tag="tV(AAC)E1"
FT   tRNA            438700..438773
FT                   /locus_tag="tV(AAC)E1"
FT                   /product="tRNA-Val"
FT                   /note="tV(AAC)E1; Valine tRNA (tRNA-Val), predicted by
FT                   tRNAscan-SE analysis"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   rep_origin      438934..439182
FT                   /note="ARS518; Autonomously Replicating Sequence"
FT   gene            439616..440971
FT                   /gene="GDI1"
FT                   /gene_synonym="SEC19"
FT                   /locus_tag="YER136W"
FT   mRNA            439616..440971
FT                   /gene="GDI1"
FT                   /gene_synonym="SEC19"
FT                   /locus_tag="YER136W"
FT                   /product="Gdi1p"
FT   CDS_pept        439616..440971
FT                   /codon_start=1
FT                   /gene="GDI1"
FT                   /gene_synonym="SEC19"
FT                   /locus_tag="YER136W"
FT                   /product="Gdi1p"
FT                   /note="GDP dissociation inhibitor; regulates vesicle
FT                   traffic in secretory pathways by regulating the
FT                   dissociation of GDP from the Sec4/Ypt/rab family of GTP
FT                   binding proteins"
FT                   /db_xref="GOA:P39958"
FT                   /db_xref="InterPro:IPR000806"
FT                   /db_xref="InterPro:IPR018203"
FT                   /db_xref="InterPro:IPR036188"
FT                   /db_xref="PDB:1UKV"
FT                   /db_xref="PDB:2BCG"
FT                   /db_xref="PDB:3CPH"
FT                   /db_xref="PDB:3CPI"
FT                   /db_xref="PDB:3CPJ"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39958"
FT                   /experiment="EXISTENCE:direct assay:GO:0005093 Rab
FT                   GDP-dissociation inhibitor activity [PMID:8157010]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016192
FT                   vesicle-mediated transport [PMID:8157010]"
FT                   /protein_id="DAA07795.1"
FT                   /translation="MDQETIDTDYDVIVLGTGITECILSGLLSVDGKKVLHIDKQDHYG
FT                   GEAASVTLSQLYEKFKQNPISKEERESKFGKDRDWNVDLIPKFLMANGELTNILIHTDV
FT                   TRYVDFKQVSGSYVFKQGKIYKVPANEIEAISSPLMGIFEKRRMKKFLEWISSYKEDDL
FT                   STHQGLDLDKNTMDEVYYKFGLGNSTKEFIGHAMALWTNDDYLQQPARPSFERILLYCQ
FT                   SVARYGKSPYLYPMYGLGELPQGFARLSAIYGGTYMLDTPIDEVLYKKDTGKFEGVKTK
FT                   LGTFKAPLVIADPTYFPEKCKSTGQRVIRAICILNHPVPNTSNADSLQIIIPQSQLGRK
FT                   SDIYVAIVSDAHNVCSKGHYLAIISTIIETDKPHIELEPAFKLLGPIEEKFMGIAELFE
FT                   PREDGSKDNIYLSRSYDASSHFESMTDDVKDIYFRVTGHPLVLKQRQEQEKQ"
FT   gene            complement(441373..441819)
FT                   /locus_tag="YER137C"
FT   mRNA            complement(441373..441819)
FT                   /locus_tag="YER137C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(441373..441819)
FT                   /codon_start=1
FT                   /locus_tag="YER137C"
FT                   /product="hypothetical protein"
FT                   /db_xref="GOA:P40083"
FT                   /db_xref="InterPro:IPR036875"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40083"
FT                   /protein_id="DAA07796.1"
FT                   /translation="MCESSNKTENDIVRLSQAMDVLAKLIISKQKDGSQLQVEYEHKLK
FT                   ELEKFINLLLGLHESTVGSMMNTSVLDMVLRNGIEIMEKDDQKYALIPIKAKEEADKTT
FT                   STIQGVTSKKSSKKKKNKIKCSFCHEAGHTRAHCGARLTVIPKK"
FT   gene            441987..442508
FT                   /locus_tag="SCR1"
FT   ncRNA           441987..442508
FT                   /locus_tag="SCR1"
FT                   /product="SCR1"
FT                   /note="RNA subunit of the Signal Recognition Particle
FT                   (SRP)"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:18418087]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005786 signal
FT                   recognition particle, endoplasmic reticulum targeting
FT                   [PMID:7925282]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006614
FT                   SRP-dependent cotranslational protein targeting to membrane
FT                   [PMID:10921896]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006614
FT                   SRP-dependent cotranslational protein targeting to membrane
FT                   [PMID:1655273]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045047 protein
FT                   targeting to ER [PMID:7925282]"
FT                   /ncRNA_class="SRP_RNA"
FT   rep_origin      442416..442735
FT                   /note="ARS519; Autonomously Replicating Sequence"
FT   repeat_region   442734..443072
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            complement(443202..443275)
FT                   /locus_tag="tI(AAU)E1"
FT   tRNA            complement(443202..443275)
FT                   /locus_tag="tI(AAU)E1"
FT                   /product="tRNA-Ile"
FT                   /note="tI(AAU)E1; Isoleucine tRNA (tRNA-Ile), predicted by
FT                   tRNAscan-SE analysis"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   mobile_element  complement(443397..449320)
FT                   /mobile_element_type="retrotransposon:YERCTy1-1"
FT                   /note="YERCTy1-1; Ty1 element, LTR retrotransposon of the
FT                   Copia (Pseudoviridae) group; contains co-transcribed genes
FT                   TYA Gag and TYB Pol, encoding proteins involved in
FT                   structure and function of virus-like particles, flanked by
FT                   two direct repeats"
FT   repeat_region   complement(443397..443733)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            complement(443756..449024)
FT                   /locus_tag="YER138C"
FT   mRNA            complement(443756..449024)
FT                   /locus_tag="YER138C"
FT                   /product="gag-pol fusion protein"
FT   CDS_pept        complement(join(443756..447721,447723..449024))
FT                   /codon_start=1
FT                   /ribosomal_slippage
FT                   /locus_tag="YER138C"
FT                   /product="gag-pol fusion protein"
FT                   /EC_number="2.7.7.49"
FT                   /EC_number="3.1.26.4"
FT                   /EC_number="2.7.7.7"
FT                   /note="Retrotransposon TYA Gag and TYB Pol genes;
FT                   transcribed/translated as one unit; polyprotein is
FT                   processed to make a nucleocapsid-like protein (Gag),
FT                   reverse transcriptase (RT), protease (PR), and integrase
FT                   (IN); similar to retroviral genes"
FT                   /db_xref="GOA:Q03612"
FT                   /db_xref="InterPro:IPR001584"
FT                   /db_xref="InterPro:IPR001969"
FT                   /db_xref="InterPro:IPR012337"
FT                   /db_xref="InterPro:IPR013103"
FT                   /db_xref="InterPro:IPR015820"
FT                   /db_xref="InterPro:IPR036397"
FT                   /db_xref="InterPro:IPR039537"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q03612"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:9448009]"
FT                   /protein_id="DAA07797.1"
FT                   /translation="MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEK
FT                   ASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFY
FT                   GHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMT
FT                   STKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYN
FT                   TFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGST
FT                   PADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELF
FT                   LDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTAR
FT                   AHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQELTESTVNHTNHSDDELPGHL
FT                   LLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVL
FT                   HTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNI
FT                   SVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDY
FT                   QCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDET
FT                   TKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKN
FT                   GITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLAS
FT                   PKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYI
FT                   IYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYQSFIASNEIQQSD
FT                   DLNIESDHDFQSDIELHPEQPRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVD
FT                   PNISESNILPSKKRSSTPQISNIESTGSGGMHKLNVPLLAPMSQSNTHESSHASKSKDF
FT                   RHSDSYSENETNHTNVPISSTGGTNNKTVPQISDQETEKRIIHRSPSIDASPPENNSSH
FT                   NIVPIKTPTTVSEQNTEESIIADLPLPDLPPESPTEFPDPFKELPPINSHQTNSSLGGI
FT                   GDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSI
FT                   KPIRTTLRYDEAITYNKDIKEKEKYIEAYHKEVNQLLKMKTWDTDEYYDRKEIDPKRVI
FT                   NSMFIFNKKRDGTHKARFVARGDIQHPDTYDSGMQSNTVHHYALMTSLSLALDNNYYIT
FT                   QLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQ
FT                   CGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESD
FT                   NEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQD
FT                   ELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSRQVLDMTYEL
FT                   IQFMWDTRDKQLIWHKNKPTEPDNKLVAISDASYGNQPYYKSQIGNIYLLNGKVIGGKS
FT                   TKASLTCTSTTEAEIHAISESVPLLNNLSYLIQELNKKPIIKGLLTDSRSTISIIKSTN
FT                   EEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTNKWIH"
FT   repeat_region   444834..445139
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            complement(447702..449024)
FT                   /locus_tag="YER137C-A"
FT   mRNA            complement(447702..449024)
FT                   /locus_tag="YER137C-A"
FT                   /product="gag protein"
FT   CDS_pept        complement(447702..449024)
FT                   /codon_start=1
FT                   /locus_tag="YER137C-A"
FT                   /product="gag protein"
FT                   /note="Retrotransposon TYA Gag gene co-transcribed with TYB
FT                   Pol; translated as TYA or TYA-TYB polyprotein; Gag is a
FT                   nucleocapsid protein that is the structural constituent of
FT                   virus-like particles (VLPs); similar to retroviral Gag"
FT                   /db_xref="GOA:P0CX71"
FT                   /db_xref="InterPro:IPR015820"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CX71"
FT                   /protein_id="DAA07798.1"
FT                   /translation="MESQQLSQHSPISHGSACASVTSKEVHTNQDPLDVSASKTEECEK
FT                   ASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFY
FT                   GHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMT
FT                   STKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYN
FT                   TFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGST
FT                   PADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELF
FT                   LDIHAIYEEQQGSRNSKPNYRRNLSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTAR
FT                   AHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPGTY"
FT   repeat_region   complement(448984..449320)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            449474..449578
FT                   /locus_tag="YER138W-A"
FT   mRNA            449474..449578
FT                   /locus_tag="YER138W-A"
FT                   /product="hypothetical protein"
FT   CDS_pept        449474..449578
FT                   /codon_start=1
FT                   /locus_tag="YER138W-A"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; YER138W-A has a paralog,
FT                   YBL107W-A, that arose from a single-locus duplication"
FT                   /db_xref="EnsemblGenomes-Gn:YER138W-A"
FT                   /db_xref="EnsemblGenomes-Tr:YER138W-A"
FT                   /db_xref="GOA:P0C270"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0C270"
FT                   /protein_id="DAA07799.1"
FT                   /translation="MIIIFIELCRIADSLLWIPKSSRRTSSISTYLIL"
FT   gene            complement(450563..451243)
FT                   /gene="RTR1"
FT                   /locus_tag="YER139C"
FT   mRNA            complement(450563..451243)
FT                   /gene="RTR1"
FT                   /locus_tag="YER139C"
FT                   /product="RNA polymerase II subunit B1 CTD phosphatase
FT                   RTR1"
FT   CDS_pept        complement(450563..451243)
FT                   /codon_start=1
FT                   /gene="RTR1"
FT                   /locus_tag="YER139C"
FT                   /product="RNA polymerase II subunit B1 CTD phosphatase
FT                   RTR1"
FT                   /EC_number="3.1.3.16"
FT                   /note="CTD phosphatase; dephosphorylates S5-P in the
FT                   C-terminal domain of Rpo21p; has a cysteine-rich motif
FT                   required for function and conserved in eukaryotes; shuttles
FT                   between the nucleus and cytoplasm; RTR1 has a paralog,
FT                   RTR2, that arose from the whole genome duplication"
FT                   /db_xref="GOA:P40084"
FT                   /db_xref="InterPro:IPR007308"
FT                   /db_xref="InterPro:IPR038534"
FT                   /db_xref="InterPro:IPR039693"
FT                   /db_xref="PDB:5C2Y"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40084"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:18408053]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:18408053|PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008420 RNA
FT                   polymerase II CTD heptapeptide repeat phosphatase activity
FT                   [PMID:19394294]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070940
FT                   dephosphorylation of RNA polymerase II C-terminal domain
FT                   [PMID:19394294]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006366
FT                   transcription by RNA polymerase II [PMID:18408053]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006366
FT                   transcription by RNA polymerase II [PMID:18408053]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0070940
FT                   dephosphorylation of RNA polymerase II C-terminal domain
FT                   [PMID:19394294]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0006366
FT                   transcription by RNA polymerase II [PMID:18408053]"
FT                   /protein_id="DAA07800.1"
FT                   /translation="MATIEDIKETALIPFQKHRQLSMHEAEVITLEIIGLLCDSECKDE
FT                   KTLKYLGRFLTPDMYQDLVDERNLNKRCGYPLCGKSPERIRDPFSMNDTTKKFLLENNP
FT                   YAYLSHYCSKFHFRCSQFYQVQLSDEALFARTGVHLFEDPEQDKHDIDFKVTLFEELLR
FT                   EKASEEDIKSLISGLKKLGLNPDSGTTEKDDTELEDDLSKWLAQIKIVENDNPSILGDF
FT                   TRED"
FT   gene            451565..453235
FT                   /gene="EMP65"
FT                   /locus_tag="YER140W"
FT   mRNA            451565..453235
FT                   /gene="EMP65"
FT                   /locus_tag="YER140W"
FT                   /product="Emp65p"
FT   CDS_pept        451565..453235
FT                   /codon_start=1
FT                   /gene="EMP65"
FT                   /locus_tag="YER140W"
FT                   /product="Emp65p"
FT                   /note="Integral membrane protein of the ER; forms an
FT                   ER-membrane associated protein complex with Slp1p;
FT                   identified along with SLP1 in a screen for mutants
FT                   defective in the unfolded protein response (UPR); proposed
FT                   to function in the folding of integral membrane proteins;
FT                   interacts genetically with MPS3; the authentic, non-tagged
FT                   protein is detected in highly purified mitochondria in
FT                   high-throughput studies"
FT                   /db_xref="GOA:P40085"
FT                   /db_xref="InterPro:IPR008010"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40085"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030176 integral
FT                   component of endoplasmic reticulum membrane
FT                   [PMID:23275891]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:26928762]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0034975
FT                   protein folding in endoplasmic reticulum [PMID:19325107]"
FT                   /protein_id="DAA07801.1"
FT                   /translation="MQHKDTAVAKDTAKKRLLRRNSAPSAIHIISRLDKKWSFLWNTID
FT                   RHNIVEEQDESSAAKSEEEHEDDYELEQLLNMIRIPMFLEKFMLFALLTSLDCFLYYFT
FT                   VLPIRLIKGYVKQFKSYRQHYRLQQRSGHKNKIPFRYRITSREYKERCMIFIIVISSIL
FT                   LSKLDTSKLYHRIKRQSTMKLYMLFSVLEMADKMLASLGQSLLTVMLSRKNSERILLHK
FT                   CLLVSMSLTYVTIHGYVLVYQAISLNIAVNSYSNALLTLLLSMQFAEIKSSVLKKFDKE
FT                   GFFQITIADVVERFKLTLLLSITGLRNLQSWSSSLSNTSINFWSPRSTLSIVINILCGP
FT                   MVSVVGSEVLVDWAKHAYITKFNRIRPQIYDKFYYIIYKDYSTRTHKLEDRLGLPLPAF
FT                   VVLFIVMVRPTLFKSSEPSYLPSLFRILFMGASVFLLALLAKFTLDLILIKWSKRIEQR
FT                   FRDQAFNTVVTEEEYVPGLLSGGMGKVDVSTRIALHSDYNKENRIETESVSPMRKRKTT
FT                   LTAECTPPSLNDIRRQKDSKNPRSLENVARYKMVSKRIW"
FT   gene            453459..454919
FT                   /gene="COX15"
FT                   /locus_tag="YER141W"
FT   mRNA            453459..454919
FT                   /gene="COX15"
FT                   /locus_tag="YER141W"
FT                   /product="Cox15p"
FT   CDS_pept        453459..454919
FT                   /codon_start=1
FT                   /gene="COX15"
FT                   /locus_tag="YER141W"
FT                   /product="Cox15p"
FT                   /note="Heme a synthase; required for the hydroxylation of
FT                   heme O to form heme A, an essential prosthetic group for
FT                   cytochrome c oxidase; oligomerization is required for
FT                   function"
FT                   /db_xref="GOA:P40086"
FT                   /db_xref="InterPro:IPR003780"
FT                   /db_xref="InterPro:IPR023754"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40086"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005743
FT                   mitochondrial inner membrane [PMID:9228094]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006784 heme
FT                   a biosynthetic process [PMID:11788607]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0016653
FT                   oxidoreductase activity, acting on NAD(P)H, heme protein as
FT                   acceptor [PMID:11788607]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006784 heme a
FT                   biosynthetic process [PMID:11788607]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016653
FT                   oxidoreductase activity, acting on NAD(P)H, heme protein as
FT                   acceptor [PMID:11248251|PMID:26940873]"
FT                   /protein_id="DAA07802.1"
FT                   /translation="MLFRNIEVGRQAAKLLTRTSSRLAWQSIGASRNISTIRQQIRKTQ
FT                   LYNFKKTVSIRPFSLSSPVFKPHVASESNPIESRLKTSKNVAYWLIGTSGLVFGIVVLG
FT                   GLTRLTESGLSITEWKPVTGTLPPMNQKEWEEEFIKYKESPEFKLLNSHIDLDEFKFIF
FT                   FMEWIHRLWGRAIGAVFILPAVYFAVSKKTSGHVNKRLFGLAGLLGLQGFVGWWMVKSG
FT                   LDQEQLDARKSKPTVSQYRLTTHLGTAFFLYMGMLWTGLEILRECKWIKNPVQAISLFK
FT                   KLDNPAIGPMRKISLALLAVSFLTAMSGGMVAGLDAGWVYNTWPKMGERWFPSSRELMD
FT                   ENFCRREDKKDLWWRNLLENPVTVQLVHRTCAYVAFTSVLAAHMYAIKKKAVIPRNAMT
FT                   SLHVMMGVVTLQATLGILTILYLVPISLASIHQAGALALLTSSLVFASQLRKPRAPMRN
FT                   VIITLPHSSKVTSGKILSEASKLASKPL"
FT   gene            complement(455146..456036)
FT                   /gene="MAG1"
FT                   /gene_synonym="MMS5"
FT                   /locus_tag="YER142C"
FT   mRNA            complement(455146..456036)
FT                   /gene="MAG1"
FT                   /gene_synonym="MMS5"
FT                   /locus_tag="YER142C"
FT                   /product="DNA-3-methyladenine glycosylase II"
FT   CDS_pept        complement(455146..456036)
FT                   /codon_start=1
FT                   /gene="MAG1"
FT                   /gene_synonym="MMS5"
FT                   /locus_tag="YER142C"
FT                   /product="DNA-3-methyladenine glycosylase II"
FT                   /EC_number="3.2.2.21"
FT                   /note="3-methyl-adenine DNA glycosylase; involved in
FT                   protecting DNA against alkylating agents; initiates base
FT                   excision repair by removing damaged bases to create abasic
FT                   sites that are subsequently repaired; protein abundance
FT                   increases in response to DNA replication stress"
FT                   /db_xref="GOA:P22134"
FT                   /db_xref="InterPro:IPR000035"
FT                   /db_xref="InterPro:IPR003265"
FT                   /db_xref="InterPro:IPR011257"
FT                   /db_xref="UniProtKB/Swiss-Prot:P22134"
FT                   /experiment="EXISTENCE:curator inference:GO:0005634 nucleus
FT                   [PMID:2265619]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA
FT                   binding [PMID:18472311]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003905 alkylbase
FT                   DNA N-glycosylase activity [PMID:2265619|PMID:2682633]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008725
FT                   DNA-3-methyladenine glycosylase activity [PMID:18472311]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006285
FT                   base-excision repair, AP site formation [PMID:18043759]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006285
FT                   base-excision repair, AP site formation [PMID:18043759]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006307 DNA
FT                   dealkylation involved in DNA repair [PMID:2265620]"
FT                   /protein_id="DAA07803.1"
FT                   /translation="MKLKREYDELIKADAVKEIAKELGSRPLEVALPEKYIARHEEKFN
FT                   MACEHILEKDPSLFPILKNNEFTLYLKETQVPNTLEDYFIRLASTILSQQISGQAAESI
FT                   KARVVSLYGGAFPDYKILFEDFKDPAKCAEIAKCGLSKRKMIYLESLAVYFTEKYKDIE
FT                   KLFGQKDNDEEVIESLVTNVKGIGPWSAKMFLISGLKRMDVFAPEDLGIARGFSKYLSD
FT                   KPELEKELMRERKVVKKSKIKHKKYNWKIYDDDIMEKCSETFSPYRSVFMFILWRLAST
FT                   NTDAMMKAEENFVKS"
FT   gene            456319..457605
FT                   /gene="DDI1"
FT                   /gene_synonym="VSM1"
FT                   /locus_tag="YER143W"
FT   mRNA            456319..457605
FT                   /gene="DDI1"
FT                   /gene_synonym="VSM1"
FT                   /locus_tag="YER143W"
FT                   /product="Ddi1p"
FT   CDS_pept        456319..457605
FT                   /codon_start=1
FT                   /gene="DDI1"
FT                   /gene_synonym="VSM1"
FT                   /locus_tag="YER143W"
FT                   /product="Ddi1p"
FT                   /note="DNA damage-inducible v-SNARE binding protein; role
FT                   in suppression of protein secretion; may play a role in
FT                   S-phase checkpoint control; has ubiquitin-associated (UBA),
FT                   ubiquitin-like (UBL), and retroviral-like proteinase (RVP)
FT                   domains"
FT                   /db_xref="GOA:P40087"
FT                   /db_xref="InterPro:IPR001995"
FT                   /db_xref="InterPro:IPR009060"
FT                   /db_xref="InterPro:IPR015940"
FT                   /db_xref="InterPro:IPR019103"
FT                   /db_xref="InterPro:IPR021109"
FT                   /db_xref="PDB:2I1A"
FT                   /db_xref="PDB:2MR9"
FT                   /db_xref="PDB:2MRO"
FT                   /db_xref="PDB:2MRP"
FT                   /db_xref="PDB:2MWS"
FT                   /db_xref="PDB:2N7E"
FT                   /db_xref="PDB:4Z2Z"
FT                   /db_xref="PDB:5KES"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40087"
FT                   /experiment="EXISTENCE:direct assay:GO:0000149 SNARE
FT                   binding [PMID:10330187]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:10330187]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin
FT                   binding [PMID:11323716]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0043328
FT                   protein transport to vacuole involved in
FT                   ubiquitin-dependent protein catabolic process via the
FT                   multivesicular body sorting pathway [PMID:29444958]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006511
FT                   ubiquitin-dependent protein catabolic process
FT                   [PMID:12051757]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0009306 protein
FT                   secretion [PMID:21094643]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016192
FT                   vesicle-mediated transport [PMID:10330187]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043328 protein
FT                   transport to vacuole involved in ubiquitin-dependent
FT                   protein catabolic process via the multivesicular body
FT                   sorting pathway [PMID:29444958]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045740 positive
FT                   regulation of DNA replication [PMID:31276951]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0072710 response
FT                   to hydroxyurea [PMID:31276951]"
FT                   /protein_id="DAA07804.1"
FT                   /translation="MDLTISNELTGEIYGPIEVSEDMALTDLIALLQADCGFDKTKHDL
FT                   YYNMDILDSNRTQSLKELGLKTDDLLLIRGKISNSIQTDAATLSDEAFIEQFRQELLNN
FT                   QMLRSQLILQIPGLNDLVNDPLLFRERLGPLILQRRYGGYNTAMNPFGIPQDEYTRLMA
FT                   NPDDPDNKKRIAELLDQQAIDEQLRNAIEYTPEMFTQVPMLYINIEINNYPVKAFVDTG
FT                   AQTTIMSTRLAKKTGLSRMIDKRFIGEARGVGTGKIIGRIHQAQVKIETQYIPCSFTVL
FT                   DTDIDVLIGLDMLKRHLACVDLKENVLRIAEVETSFLSEAEIPKSFQEGLPAPTSVTTS
FT                   SDKPLTPTKTSSTLPPQPGAVPALAPRTGMGPTPTGRSTAGATTATGRTFPEQTIKQLM
FT                   DLGFPRDAVVKALKQTNGNAEFAASLLFQ"
FT   gene            complement(457806..460223)
FT                   /gene="UBP5"
FT                   /locus_tag="YER144C"
FT   mRNA            complement(457806..460223)
FT                   /gene="UBP5"
FT                   /locus_tag="YER144C"
FT                   /product="putative ubiquitin-specific protease UBP5"
FT   CDS_pept        complement(457806..460223)
FT                   /codon_start=1
FT                   /gene="UBP5"
FT                   /locus_tag="YER144C"
FT                   /product="putative ubiquitin-specific protease UBP5"
FT                   /EC_number="3.4.19.12"
FT                   /note="Putative ubiquitin-specific protease; concentrates
FT                   at the bud neck; UBP5 has a paralog, DOA4, that arose from
FT                   the whole genome duplication"
FT                   /db_xref="GOA:P39944"
FT                   /db_xref="InterPro:IPR001394"
FT                   /db_xref="InterPro:IPR001763"
FT                   /db_xref="InterPro:IPR018200"
FT                   /db_xref="InterPro:IPR028889"
FT                   /db_xref="InterPro:IPR036873"
FT                   /db_xref="InterPro:IPR038765"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39944"
FT                   /experiment="EXISTENCE:direct assay:GO:0000131 incipient
FT                   cellular bud site [PMID:17145966]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud
FT                   neck [PMID:17145966]"
FT                   /protein_id="DAA07805.1"
FT                   /translation="MGSEQALSEVVESAKERFGRLRHLVQKFLDDDDVPQECLPLLQEC
FT                   AEIWSSYVDACQDITMQAPKEDANRLSKGFLRLNETAFLYYMIVYTLLEDTLPRLKEFS
FT                   SNKDQNVRNLYGERIQLLHNDPNIERIRNVIENYPKFIQLQTIEPGKLSSMLHFHGDAL
FT                   LLIDVRPRSEFVRAHIKCKNIICIDPASFKDSFTDQQIESVSLITSPHSDITFFSNRDK
FT                   FKFIILYTDTQLHNNFQQRQTRILAKILSQNSVIKPLSGTKILILENGFSNWVKLGGAY
FT                   QSSVSETAHLTSSSSTPAFGSPQVPTGLFNQKSLSPNKDKSMPMVSMNTQPLLTTVQRP
FT                   QLPLYYSDLPIIPQPSPNRNSPTVQKFSPHPPTTLSKLNTPSTIQNKANTVERISPDIR
FT                   AAQAHAYLPPASNVFSPRIPPLPQQNLSSSRQTILNNSQVLDLDLIVGLENIGNCCYMN
FT                   CILQCLVGTHDLVRMFLDNTYLNFINFDSSRGSKGLLAKNFAILVNNMHRHGAFTPPNV
FT                   RTIPVQTIQFKKICGHINPMYSDSMQQDCQEFCQFLLDGLHEDLNQNGSKKHLKQLSDE
FT                   EERMREKMSIRKASALEWERFLLTDFSAIIDLFQGQYASRLQCQVCEHTSTTYQTFSVL
FT                   SVPVPRVKTCNILDCFREFTKCERLGVDEQWSCPKCLKKQPSTKQLKITRLPKKLIINL
FT                   KRFDNQMNKNNVFVQYPYSLDLTPYWARDFNHEAIVNEDIPTRGQVPPFRYRLYGVACH
FT                   SGSLYGGHYTSYVYKGPKKGWYFFDDSLYRPITFSTEFITPSAYVLFYERIF"
FT   gene            complement(460526..461740)
FT                   /gene="FTR1"
FT                   /locus_tag="YER145C"
FT   mRNA            complement(460526..461740)
FT                   /gene="FTR1"
FT                   /locus_tag="YER145C"
FT                   /product="high-affinity iron permease FTR1"
FT   CDS_pept        complement(460526..461740)
FT                   /codon_start=1
FT                   /gene="FTR1"
FT                   /locus_tag="YER145C"
FT                   /product="high-affinity iron permease FTR1"
FT                   /note="High affinity iron permease; involved in the
FT                   transport of iron across the plasma membrane; forms complex
FT                   with Fet3p; expression is regulated by iron; protein
FT                   abundance increases in response to DNA replication stress"
FT                   /db_xref="GOA:P40088"
FT                   /db_xref="InterPro:IPR004923"
FT                   /db_xref="InterPro:IPR005217"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40088"
FT                   /experiment="EXISTENCE:direct assay:GO:0005381 iron ion
FT                   transmembrane transporter activity
FT                   [PMID:16700543|PMID:8599111]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:10748025|PMID:16700543]"
FT                   /experiment="EXISTENCE:direct assay:GO:0033573
FT                   high-affinity iron permease complex [PMID:16522632]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0034755 iron
FT                   ion transmembrane transport [PMID:8599111]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:1901684
FT                   arsenate ion transmembrane transport [PMID:23295455]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034755 iron ion
FT                   transmembrane transport [PMID:16700543|PMID:8599111]"
FT                   /protein_id="DAA07806.1"
FT                   /translation="MPNKVFNVAVFFVVFRECLEAVIVISVLLSFLKQAIGEHDRALYR
FT                   KLRIQVWVGVLLGFIICLAIGAGFIGAYYSLQKDIFGSAEDLWEGIFCMIATIMISMMG
FT                   IPMLRMNKMQSKWRVKIARSLVEIPHRKRDYFKIGFLSRRYAMFLLPFITVLREGLEAV
FT                   VFVAGAGITTQGSHASAYPLPVVVGLICGGLVGYLLYYGASKSSLQIFLILSTSILYLI
FT                   SAGLFSRGAWYFENYRFNLASGGDASEGGDGNGSYNIRKAVYHVNCCNPELDNGWDIFN
FT                   ALLGWQNTGYLSSMLCYNIYWLVLIIVLSLMIFEERRGHLPFTKNLQLKHLNPGYWIKN
FT                   KKKQELTEEQKRQLFAKMENINFNEDGEINVQENYELPEQTTSHSSSQNVATDKEVLHV
FT                   KADSL"
FT   gene            complement(462386..462823)
FT                   /locus_tag="YER145C-A"
FT   mRNA            complement(462386..462823)
FT                   /locus_tag="YER145C-A"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(462386..462823)
FT                   /codon_start=1
FT                   /locus_tag="YER145C-A"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; conserved among S. cerevisiae
FT                   strains; overlaps verified ORF LSM5/YER146W"
FT                   /db_xref="GOA:A0A023PYF4"
FT                   /db_xref="UniProtKB/Swiss-Prot:A0A023PYF4"
FT                   /protein_id="DAA80289.1"
FT                   /translation="MAILLPLKSILPWCCITFSFLLSSSGSISHSTASSSITLTKSSKP
FT                   TNVPSNSRFDCSTINTFWLIVLSMTSKGKISGRLILRASVYACECTCIRYACCETIYPP
FT                   RKPFSLSLYFFYFNKKASILFCYPDAKTKPEHPGNKRAGSG"
FT   gene            462585..462866
FT                   /gene="LSM5"
FT                   /locus_tag="YER146W"
FT   mRNA            462585..462866
FT                   /gene="LSM5"
FT                   /locus_tag="YER146W"
FT                   /product="RNA-binding protein LSM5"
FT   CDS_pept        462585..462866
FT                   /codon_start=1
FT                   /gene="LSM5"
FT                   /locus_tag="YER146W"
FT                   /product="RNA-binding protein LSM5"
FT                   /note="Lsm (Like Sm) protein; part of heteroheptameric
FT                   complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic
FT                   Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex
FT                   part of U6 snRNP and possibly involved in processing tRNA,
FT                   snoRNA, and rRNA"
FT                   /db_xref="GOA:P40089"
FT                   /db_xref="InterPro:IPR001163"
FT                   /db_xref="InterPro:IPR010920"
FT                   /db_xref="InterPro:IPR033871"
FT                   /db_xref="PDB:3JCM"
FT                   /db_xref="PDB:4C8Q"
FT                   /db_xref="PDB:4C92"
FT                   /db_xref="PDB:4M75"
FT                   /db_xref="PDB:4M77"
FT                   /db_xref="PDB:4M78"
FT                   /db_xref="PDB:4M7A"
FT                   /db_xref="PDB:4M7D"
FT                   /db_xref="PDB:5GAN"
FT                   /db_xref="PDB:5NRL"
FT                   /db_xref="PDB:5VSU"
FT                   /db_xref="PDB:5ZWM"
FT                   /db_xref="PDB:5ZWO"
FT                   /db_xref="PDB:6ASO"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40089"
FT                   /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding
FT                   [PMID:15075370|PMID:10369684]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP
FT                   [PMID:10369684|PMID:11720284]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus
FT                   [PMID:15075370]"
FT                   /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5
FT                   tri-snRNP complex [PMID:10377396|PMID:10449419]"
FT                   /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1
FT                   complex [PMID:24139796]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA
FT                   splicing, via spliceosome [PMID:10428970]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0005732
FT                   small nucleolar ribonucleoprotein complex [PMID:15075370]"
FT                   /protein_id="DAA07807.1"
FT                   /translation="MSLPEILPLEVIDKTINQKVLIVLQSNREFEGTLVGFDDFVNVIL
FT                   EDAVEWLIDPEDESRNEKVMQHHGRMLLSGNNIAILVPGGKKTPTEAL"
FT   gene            complement(462968..464842)
FT                   /gene="SCC4"
FT                   /locus_tag="YER147C"
FT   mRNA            complement(462968..464842)
FT                   /gene="SCC4"
FT                   /locus_tag="YER147C"
FT                   /product="cohesin-loading factor complex subunit SCC4"
FT   CDS_pept        complement(462968..464842)
FT                   /codon_start=1
FT                   /gene="SCC4"
FT                   /locus_tag="YER147C"
FT                   /product="cohesin-loading factor complex subunit SCC4"
FT                   /note="Subunit of cohesin loading factor (Scc2p-Scc4p);
FT                   complex is required for the loading of cohesin complexes
FT                   onto chromosomes; involved in establishing sister chromatid
FT                   cohesion during double-strand break repair via
FT                   phosphorylated histone H2AX"
FT                   /db_xref="GOA:P40090"
FT                   /db_xref="InterPro:IPR019440"
FT                   /db_xref="PDB:4XDN"
FT                   /db_xref="PDB:5W94"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40090"
FT                   /experiment="EXISTENCE:direct assay:GO:0000790 nuclear
FT                   chromatin [PMID:10882066]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043515 kinetochore
FT                   binding [PMID:28938124]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006302
FT                   double-strand break repair [PMID:15610742]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic
FT                   sister chromatid cohesion [PMID:10882066]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic
FT                   chromosome condensation [PMID:18708580]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA
FT                   condensation [PMID:18708580]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0071169
FT                   establishment of protein localization to chromatin
FT                   [PMID:10882066]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0032116 SMC
FT                   loading complex [PMID:10882066]"
FT                   /protein_id="DAA07808.1"
FT                   /translation="MENLGDKLSISQVYHLAQEYRDHAYSIANKIGSEEGLKQYYGLMN
FT                   MSIQMFQLLKTKCTLSVLEDSKVTFEMVELLIQETYNFDLAELYISSLKERLQTHQSDT
FT                   DLVEEIMRCEFLLLHDLPLMRDSKFHYKIALRNCNELVQYMVNLQDELYQNWASVFQYV
FT                   GVMLCIKLKQHRRVKTSFHGLLSQCREKSQWKWFLNLCYVNYLLNERFPIPEDALQELR
FT                   STELHTVGPELYAWKLALEMVIQLCKDGNITDHLNEFKNFFDTNKQSLVTNEGKGCVIK
FT                   IMPRIALKVELPMIFHYKELKNILLLLQSVSYIVNCYDEKGNFSRKFLPKVYSTTQKLI
FT                   KNIAAGGVSMNELDSRIQTYKSILEFCEFYKVWEQTLLKGAVVTTESPKLGPSPGYVRL
FT                   LQAMKVQFEGGGAVEEYTRLAQSGGTSSEVKMISLLNCYTVQAARVSRCSGDKQGELVE
FT                   QCNKVWLQVEKLLQETDLQFNPIWECTVTILWLFSHFEPFSWNPLPCSDKQRAEYVSKL
FT                   REFYSSNKFVAGEAVADNRFKLKKALLLQILVNYLGGRMLEHDLGEIYAISAKCFDMCR
FT                   QQGGMRKVQYVIGIWHLMNCTVAMRGKDVALTNAKLEALVKQITSVKQ"
FT   gene            465303..466025
FT                   /gene="SPT15"
FT                   /gene_synonym="BTF1"
FT                   /gene_synonym="TBP1"
FT                   /locus_tag="YER148W"
FT   mRNA            465303..466025
FT                   /gene="SPT15"
FT                   /gene_synonym="BTF1"
FT                   /gene_synonym="TBP1"
FT                   /locus_tag="YER148W"
FT                   /product="TATA-binding protein"
FT   CDS_pept        465303..466025
FT                   /codon_start=1
FT                   /gene="SPT15"
FT                   /gene_synonym="BTF1"
FT                   /gene_synonym="TBP1"
FT                   /locus_tag="YER148W"
FT                   /product="TATA-binding protein"
FT                   /note="TATA-binding protein (TBP); general transcription
FT                   factor that interacts with other factors to form the
FT                   preinitiation complex at promoters; essential for
FT                   viability, highly conserved; yeast gene can complement
FT                   mutations in human homolog TBP"
FT                   /db_xref="GOA:P13393"
FT                   /db_xref="InterPro:IPR000814"
FT                   /db_xref="InterPro:IPR012295"
FT                   /db_xref="InterPro:IPR030491"
FT                   /db_xref="InterPro:IPR033710"
FT                   /db_xref="PDB:1NGM"
FT                   /db_xref="PDB:1NH2"
FT                   /db_xref="PDB:1RM1"
FT                   /db_xref="PDB:1TBA"
FT                   /db_xref="PDB:1TBP"
FT                   /db_xref="PDB:1YTB"
FT                   /db_xref="PDB:1YTF"
FT                   /db_xref="PDB:4B0A"
FT                   /db_xref="PDB:4V1N"
FT                   /db_xref="PDB:4V1O"
FT                   /db_xref="PDB:5FMF"
FT                   /db_xref="PDB:5FYW"
FT                   /db_xref="PDB:5FZ5"
FT                   /db_xref="PDB:5OQJ"
FT                   /db_xref="PDB:5OQM"
FT                   /db_xref="PDB:5SVA"
FT                   /db_xref="PDB:6CNB"
FT                   /db_xref="PDB:6CNC"
FT                   /db_xref="PDB:6CND"
FT                   /db_xref="PDB:6CNF"
FT                   /db_xref="PDB:6EU0"
FT                   /db_xref="PDB:6F40"
FT                   /db_xref="PDB:6F41"
FT                   /db_xref="PDB:6F42"
FT                   /db_xref="PDB:6F44"
FT                   /db_xref="PDB:6GYK"
FT                   /db_xref="PDB:6GYL"
FT                   /db_xref="PDB:6GYM"
FT                   /db_xref="UniProtKB/Swiss-Prot:P13393"
FT                   /experiment="EXISTENCE:curator inference:GO:0000995 RNA
FT                   polymerase III general transcription initiation factor
FT                   activity []"
FT                   /experiment="EXISTENCE:curator inference:GO:0016251 RNA
FT                   polymerase II general transcription initiation factor
FT                   activity []"
FT                   /experiment="EXISTENCE:direct assay:GO:0000126
FT                   transcription factor TFIIIB complex
FT                   [PMID:1423590|PMID:1458536]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000979 RNA
FT                   polymerase II core promoter sequence-specific DNA binding
FT                   [PMID:2677740]"
FT                   /experiment="EXISTENCE:direct assay:GO:0001016 RNA
FT                   polymerase III regulatory region DNA binding
FT                   [PMID:8662956]"
FT                   /experiment="EXISTENCE:direct assay:GO:0001102 RNA
FT                   polymerase II activating transcription factor binding
FT                   [PMID:12501245]"
FT                   /experiment="EXISTENCE:direct assay:GO:0001179 RNA
FT                   polymerase I general transcription initiation factor
FT                   binding [PMID:8895657]"
FT                   /experiment="EXISTENCE:direct assay:GO:0001186 RNA
FT                   polymerase I transcription regulator recruiting activity
FT                   [PMID:8895657]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003682 chromatin
FT                   binding [PMID:19098311]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:9818719]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005669
FT                   transcription factor TFIID complex
FT                   [PMID:10788514|PMID:15448131]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding,
FT                   bending [PMID:1736286]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070893 transposon
FT                   integration [PMID:10882723]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070898 RNA
FT                   polymerase III preinitiation complex assembly
FT                   [PMID:1480467]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0042790
FT                   nucleolar large rRNA transcription by RNA polymerase I
FT                   [PMID:1586947]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA
FT                   polymerase II preinitiation complex assembly
FT                   [PMID:12840001]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0001102 RNA
FT                   polymerase II activating transcription factor binding
FT                   [PMID:12501245]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0001179 RNA
FT                   polymerase I general transcription initiation factor
FT                   binding [PMID:8895657]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0001186 RNA
FT                   polymerase I transcription regulator recruiting activity
FT                   [PMID:8895657]"
FT                   /protein_id="DAA07809.1"
FT                   /translation="MADEERLKEFKEANKIVFDPNTRQVWENQNRDGTKPATTFQSEED
FT                   IKRAAPESEKDTSATSGIVPTLQNIVATVTLGCRLDLKTVALHARNAEYNPKRFAAVIM
FT                   RIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKIGFAAKFTDFKIQNIVGS
FT                   CDVKFPIRLEGLAFSHGTFSSYEPELFPGLIYRMVKPKIVLLIFVSGKIVLTGAKQREE
FT                   IYQAFEAIYPVLSEFRKM"
FT   gene            complement(466208..467470)
FT                   /gene="PEA2"
FT                   /gene_synonym="DFG9"
FT                   /gene_synonym="PPF2"
FT                   /locus_tag="YER149C"
FT   mRNA            complement(466208..467470)
FT                   /gene="PEA2"
FT                   /gene_synonym="DFG9"
FT                   /gene_synonym="PPF2"
FT                   /locus_tag="YER149C"
FT                   /product="Pea2p"
FT   CDS_pept        complement(466208..467470)
FT                   /codon_start=1
FT                   /gene="PEA2"
FT                   /gene_synonym="DFG9"
FT                   /gene_synonym="PPF2"
FT                   /locus_tag="YER149C"
FT                   /product="Pea2p"
FT                   /note="Coiled-coil 12S polarisome subunit; required for
FT                   polarity establishment, apical bud growth, shmoo formation,
FT                   filamentous differentiation; involved in Bni1p localization
FT                   at sites of polarized growth, controlling polarized
FT                   assembly of actin cables; role in apical growth affects
FT                   diploid-specific bipolar bud site selection; retains Slt2p
FT                   at bud tip to regulate ER inheritance; role in Ca2+ influx,
FT                   cell fusion; S288C allele encoding Leu409 rather than Met
FT                   linked with non-invasion"
FT                   /db_xref="GOA:P40091"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40091"
FT                   /experiment="EXISTENCE:direct assay:GO:0000131 incipient
FT                   cellular bud site [PMID:8909546]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000133 polarisome
FT                   [PMID:9632790]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud
FT                   [PMID:8909546]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud
FT                   tip [PMID:8909546]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud
FT                   neck [PMID:8909546]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043332 mating
FT                   projection tip [PMID:8909546|PMID:19053807]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007118
FT                   budding cell apical bud growth [PMID:10866679]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding
FT                   cell apical bud growth [PMID:10866679]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar
FT                   cellular bud site selection [PMID:8909546]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007124
FT                   pseudohyphal growth [PMID:9055077]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030010
FT                   establishment of cell polarity [PMID:8013906|PMID:8909546]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030447
FT                   filamentous growth [PMID:15645503]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031384
FT                   regulation of initiation of mating projection growth
FT                   [PMID:14734532]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031385
FT                   regulation of termination of mating projection growth
FT                   [PMID:14734532]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032880
FT                   regulation of protein localization
FT                   [PMID:10085294|PMID:11740491|PMID:8909546]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000251 positive
FT                   regulation of actin cytoskeleton reorganization
FT                   [PMID:17237521|PMID:19633059]"
FT                   /protein_id="DAA07810.1"
FT                   /translation="MHKFDLELSRRANPLLFSAERYEEYPLKYDELKQYLLSQNPSHPH
FT                   HNSRPYTSIDYFDYLLYRSKNDESEIDLDKKLVSEFALYYVQKEHLNSDDLNPTLNELL
FT                   KLQPKSADWYEMMLRILESINTTGIDQLTKENNNSFPNSKRARSSTNMGGTDKFNKGAY
FT                   HTDKADDDKNEILQELTSFLMSNSIQKGIDIKPIPLDDPVKFLKNGINSILDTCVSLEK
FT                   NTSSPPISPNAAAIQEEDSSKKLEELETAFSDLQLAHNFLTKQFENDRAEYVQDIEKLT
FT                   RTNRELQDKLLNNHSNLSKTEKKLHELEQENKELEKANNKLNSSRHNFGMSSPASSPVT
FT                   WDPSSPSSVGSPTSGSGSRSLSIMTSEFKKVLTSTQRKYEKELSDEREHRFKLERELAL
FT                   LKNAEANTSLALNRDDPPDML"
FT   gene            468370..468816
FT                   /gene="SPI1"
FT                   /locus_tag="YER150W"
FT   mRNA            468370..468816
FT                   /gene="SPI1"
FT                   /locus_tag="YER150W"
FT                   /product="Spi1p"
FT   CDS_pept        468370..468816
FT                   /codon_start=1
FT                   /gene="SPI1"
FT                   /locus_tag="YER150W"
FT                   /product="Spi1p"
FT                   /note="GPI-anchored cell wall protein involved in weak acid
FT                   resistance; basal expression requires Msn2p/Msn4p;
FT                   expression is induced under conditions of stress and during
FT                   the diauxic shift; SPI1 has a paralog, SED1, that arose
FT                   from the whole genome duplication"
FT                   /db_xref="GOA:P40092"
FT                   /db_xref="InterPro:IPR038843"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40092"
FT                   /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type
FT                   cell wall [PMID:9613572]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:26928762]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010447 response
FT                   to acidic pH [PMID:16980434]"
FT                   /protein_id="DAA07811.1"
FT                   /translation="MLSNAKLLLSLAMASTALGLVSNSSSSVIVVPSSDATIAGNDTAT
FT                   PAPEPSSAAPIFYNSTATATQYEVVSEFTTYCPEPTTFVTNGATFTVTAPTTLTITNCP
FT                   CTIEKPTSETSVSSTHDVETNSNAANARAIPGALGLAGAVMMLL"
FT   gene            469457..469530
FT                   /locus_tag="tV(AAC)E2"
FT   tRNA            469457..469530
FT                   /locus_tag="tV(AAC)E2"
FT                   /product="tRNA-Val"
FT                   /note="tV(AAC)E2; Valine tRNA (tRNA-Val), predicted by
FT                   tRNAscan-SE analysis"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   gene            complement(469686..472424)
FT                   /gene="UBP3"
FT                   /gene_synonym="BLM3"
FT                   /locus_tag="YER151C"
FT   mRNA            complement(469686..472424)
FT                   /gene="UBP3"
FT                   /gene_synonym="BLM3"
FT                   /locus_tag="YER151C"
FT                   /product="mRNA-binding ubiquitin-specific protease UBP3"
FT   CDS_pept        complement(469686..472424)
FT                   /codon_start=1
FT                   /gene="UBP3"
FT                   /gene_synonym="BLM3"
FT                   /locus_tag="YER151C"
FT                   /product="mRNA-binding ubiquitin-specific protease UBP3"
FT                   /EC_number="3.4.19.12"
FT                   /note="Ubiquitin-specific protease involved in transport
FT                   and osmotic response; negatively regulates Ras/PKA
FT                   signaling; interacts with Bre5p to coregulate anterograde,
FT                   retrograde transport between ER and Golgi; involved in
FT                   transcription elongation in response to osmostress through
FT                   phosphorylation at Ser695 by Hog1p; inhibitor of gene
FT                   silencing; role in ribophagy; cleaves ubiquitin fusions but
FT                   not polyubiquitin; protein abundance increases in response
FT                   to DNA replication stress"
FT                   /db_xref="GOA:Q01477"
FT                   /db_xref="InterPro:IPR001394"
FT                   /db_xref="InterPro:IPR018200"
FT                   /db_xref="InterPro:IPR028889"
FT                   /db_xref="InterPro:IPR038765"
FT                   /db_xref="PDB:2QIY"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q01477"
FT                   /experiment="EXISTENCE:curator inference:GO:0005737
FT                   cytoplasm [PMID:1429680]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding
FT                   [PMID:20844764|PMID:23222640]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004843
FT                   thiol-dependent ubiquitin-specific protease activity
FT                   [PMID:1429680]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:23222640]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016579 protein
FT                   deubiquitination [PMID:18498751]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004843
FT                   thiol-dependent ubiquitin-specific protease activity
FT                   [PMID:23476013]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016579 protein
FT                   deubiquitination
FT                   [PMID:18498751|PMID:23476013|PMID:23645675]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034517
FT                   ribophagy [PMID:18391941]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0047484
FT                   regulation of response to osmotic stress [PMID:21743437]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0060628
FT                   regulation of ER to Golgi vesicle-mediated transport
FT                   [PMID:12778054]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0047484
FT                   regulation of response to osmotic stress [PMID:21743437]"
FT                   /experiment="EXISTENCE:physical interaction:GO:1990861
FT                   Ubp3-Bre5 deubiquitination complex [PMID:12778054]"
FT                   /protein_id="DAA07812.1"
FT                   /translation="MNMQDANKEESYSMYPKTSSPPPPTPTNMQIPIYQAPLQMYGYTQ
FT                   APYLYPTQIPAYSFNMVNQNQPIYHQSGSPHHLPPQNNINGGSTTNNNNINKKKWHSNG
FT                   ITNNNGSSGNQGANSSGSGMSYNKSHTYHHNYSNNHIPMMASPNSGSNAGMKKQTNSSN
FT                   GNGSSATSPSYSSYNSSSQYDLYKFDVTKLKNLKENSSNLIQLPLFINTTEAEFAAASV
FT                   QRYELNMKALNLNSESLENSSVEKSSAHHHTKSHSIPKHNEEVKTETHGEEEDAHDKKP
FT                   HASKDAHELKKKTEVKKEDAKQDRNEKVIQEPQATVLPVVDKKEPEESVEENTSKTSSP
FT                   SPSPPAAKSWSAIASDAIKSRQASNKTVSGSMVTKTPISGTTAGVSSTNMAAATIGKSS
FT                   SPLLSKQPQKKDKKYVPPSTKGIEPLGSIALRMCFDPDFISYVLRNKDVENKIPVHSII
FT                   PRGIINRANICFMSSVLQVLLYCKPFIDVINVLSTRNTNSRVGTSSCKLLDACLTMYKQ
FT                   FDKETYEKKFLENADDAEKTTESDAKKSSKSKSFQHCATADAVKPDEFYKTLSTIPKFK
FT                   DLQWGHQEDAEEFLTHLLDQLHEELISAIDGLTDNEIQNMLQSINDEQLKVFFIRNLSR
FT                   YGKAEFIKNASPRLKELIEKYGVINDDSTEENGWHEVSGSSKRGKKTKTAAKRTVEIVP
FT                   SPISKLFGGQFRSVLDIPNNKESQSITLDPFQTIQLDISDAGVNDLETAFKKFSEYELL
FT                   PFKSSSGNDVEAKKQTFIDKLPQVLLIQFKRFSFINNVNKDNAMTNYNAYNGRIEKIRK
FT                   KIKYGHELIIPEESMSSITLKNNTSGIDDRRYKLTGVIYHHGVSSDGGHYTADVYHSEH
FT                   NKWYRIDDVNITELEDDDVLKGGEEASDSRTAYILMYQKRN"
FT   gene            complement(472657..473988)
FT                   /locus_tag="YER152C"
FT   mRNA            complement(472657..473988)
FT                   /locus_tag="YER152C"
FT                   /product="2-aminoadipate transaminase"
FT   CDS_pept        complement(472657..473988)
FT                   /codon_start=1
FT                   /locus_tag="YER152C"
FT                   /product="2-aminoadipate transaminase"
FT                   /note="Protein with 2-aminoadipate transaminase activity;
FT                   shares amino acid similarity with the aminotransferases
FT                   Aro8p and Aro9p; YER152C is not an essential gene"
FT                   /db_xref="GOA:P10356"
FT                   /db_xref="InterPro:IPR004839"
FT                   /db_xref="InterPro:IPR015421"
FT                   /db_xref="InterPro:IPR015422"
FT                   /db_xref="InterPro:IPR015424"
FT                   /db_xref="UniProtKB/Swiss-Prot:P10356"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0047536
FT                   2-aminoadipate transaminase activity [PMID:19342587]"
FT                   /protein_id="DAA07813.1"
FT                   /translation="MKYKEINFFKGHPSSRLLPREAVIQATAAILGPETREYDNDPYNR
FT                   HPLTYGSDEGALWVREQICTFLNDQLFKFENGARSRTRADYLNLNSGASYGMLNILLQT
FT                   TLPHNGYTRQAFIITPTYFLINNCFTDAGFKGKMTAINEQGHDSIDFESLISALEQHEA
FT                   EPQPHSTTEMIQGPKLTKKVYRYVMYCIPTFANPSGNTYSLETRRRLIDIARKYDMLII
FT                   TDDVYDILDYTTPSDELPSPPLRMVHIDRSTAPSGEDSFGNTVSNATFSKLIAPGLRFG
FT                   YHESINANLARQLSKGGANVSGGTPSQLNSMIVGEMLRSGAAQRCIAHLRSVYSERATV
FT                   LTSALKKYMPLGTEIMPLKGGYFTWITLPPAYNAMEISTILAKKFNVILADGSNFEVIG
FT                   DEKNWGQSCFRLSISFLEVDDIDRGIELFGAVCKSHAITNNITM"
FT   gene            complement(474041..474805)
FT                   /gene="PET122"
FT                   /locus_tag="YER153C"
FT   mRNA            complement(474041..474805)
FT                   /gene="PET122"
FT                   /locus_tag="YER153C"
FT                   /product="Pet122p"
FT   CDS_pept        complement(474041..474805)
FT                   /codon_start=1
FT                   /gene="PET122"
FT                   /locus_tag="YER153C"
FT                   /product="Pet122p"
FT                   /note="Mitochondrial translational activator specific for
FT                   the COX3 mRNA; acts together with Pet54p and Pet494p;
FT                   located in the mitochondrial inner membrane"
FT                   /db_xref="GOA:P10355"
FT                   /db_xref="InterPro:IPR008732"
FT                   /db_xref="UniProtKB/Swiss-Prot:P10355"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005743
FT                   mitochondrial inner membrane [PMID:8389363]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031305 integral
FT                   component of mitochondrial inner membrane [PMID:12529447]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003743
FT                   translation initiation factor activity [PMID:2833749]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0033617
FT                   mitochondrial respiratory chain complex IV assembly
FT                   [PMID:2833749]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive
FT                   regulation of mitochondrial translation [PMID:2833749]"
FT                   /protein_id="DAA07814.1"
FT                   /translation="MLTITKRLVTTDVRSRILLSSLNGKMSDALALLRQQQQTSVDVEL
FT                   LHTMLARAAALAHADTIAYMWYQHVMPRRLPVEGRLLCEMAGVALYQDRLFLPAQFLQH
FT                   YQAMNRDRRTSPEDELIEYELRRIKVEAFARGTMHSTALREKWKVFLQEMDTLPGQPPL
FT                   RLRDFPQMTKAMGIALMQQDEQAAALALFGRQPLVIKNEWSLPLLLAGVLWHVPGPAQA
FT                   RRVLAEFRQSYRGLPLLDAELVIKRRGFEINT"
FT   gene            475020..476228
FT                   /gene="OXA1"
FT                   /locus_tag="YER154W"
FT   mRNA            475020..476228
FT                   /gene="OXA1"
FT                   /locus_tag="YER154W"
FT                   /product="membrane insertase OXA1"
FT   CDS_pept        475020..476228
FT                   /codon_start=1
FT                   /gene="OXA1"
FT                   /locus_tag="YER154W"
FT                   /product="membrane insertase OXA1"
FT                   /note="Mitochondrial inner membrane insertase; mediates the
FT                   insertion of both mitochondrial- and nuclear-encoded
FT                   proteins from the matrix into the inner membrane; also has
FT                   a role in insertion of carrier proteins into the inner
FT                   membrane; acts as a voltage-gated ion channel, activated by
FT                   substrate peptides; interacts with mitochondrial ribosomes;
FT                   conserved from bacteria to animals"
FT                   /db_xref="GOA:P39952"
FT                   /db_xref="InterPro:IPR001708"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39952"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030061
FT                   mitochondrial crista [PMID:22513091]"
FT                   /experiment="EXISTENCE:direct assay:GO:0097002
FT                   mitochondrial inner boundary membrane [PMID:22513091]"
FT                   /experiment="EXISTENCE:direct assay:GO:0097177
FT                   mitochondrial ribosome binding [PMID:14657018]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032977 membrane
FT                   insertase activity [PMID:9285818|PMID:9428747]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032979 protein
FT                   insertion into mitochondrial inner membrane from matrix
FT                   [PMID:17452441|PMID:9285818|PMID:9428747|PMID:9482871]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0033615
FT                   mitochondrial proton-transporting ATP synthase complex
FT                   assembly [PMID:17344477]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein
FT                   insertion into mitochondrial inner membrane
FT                   [PMID:22846909]"
FT                   /protein_id="DAA07815.1"
FT                   /translation="MFKLTSRLVTSRFAASSRLATARTIVLPRPHPSWISFQAKRFNST
FT                   GPNANDVSEIQTQLPSIDELTSSAPSLSASTSDLIANTTQTVGELSSHIGYLNSIGLAQ
FT                   TWYWPSDIIQHVLEAVHVYSGLPWWGTIAATTILIRCLMFPLYVKSSDTVARNSHIKPE
FT                   LDALNNKLMSTTDLQQGQLVAMQRKKLLSSHGIKNRWLAAPMLQIPIALGFFNALRHMA
FT                   NYPVDGFANQGVAWFTDLTQADPYLGLQVITAAVFISFTRLGGETGAQQFSSPMKRLFT
FT                   ILPIISIPATMNLSSAVVLYFAFNGAFSVLQTMILRNKWVRSKLKITEVAKPRTPIAGA
FT                   SPTENMGIFQSLKHNIQKARDQAERRQLMQDNEKKLQESFKEKRQNSKIKIVHKSNFIN
FT                   NKK"
FT   gene            complement(476345..482848)
FT                   /gene="BEM2"
FT                   /gene_synonym="IPL2"
FT                   /gene_synonym="SUP9"
FT                   /gene_synonym="TSL1"
FT                   /locus_tag="YER155C"
FT   mRNA            complement(476345..482848)
FT                   /gene="BEM2"
FT                   /gene_synonym="IPL2"
FT                   /gene_synonym="SUP9"
FT                   /gene_synonym="TSL1"
FT                   /locus_tag="YER155C"
FT                   /product="Bem2p"
FT   CDS_pept        complement(476345..482848)
FT                   /codon_start=1
FT                   /gene="BEM2"
FT                   /gene_synonym="IPL2"
FT                   /gene_synonym="SUP9"
FT                   /gene_synonym="TSL1"
FT                   /locus_tag="YER155C"
FT                   /product="Bem2p"
FT                   /note="Rho GTPase activating protein (RhoGAP); involved in
FT                   the control of cytoskeleton organization and cellular
FT                   morphogenesis; required for bud emergence; potential GAP
FT                   for Rho4p"
FT                   /db_xref="GOA:P39960"
FT                   /db_xref="InterPro:IPR000198"
FT                   /db_xref="InterPro:IPR000651"
FT                   /db_xref="InterPro:IPR001849"
FT                   /db_xref="InterPro:IPR001895"
FT                   /db_xref="InterPro:IPR008936"
FT                   /db_xref="InterPro:IPR011993"
FT                   /db_xref="InterPro:IPR023578"
FT                   /db_xref="InterPro:IPR036964"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39960"
FT                   /experiment="EXISTENCE:direct assay:GO:0000131 incipient
FT                   cellular bud site [PMID:17914457]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding
FT                   [PMID:23222640]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005096 GTPase
FT                   activator activity [PMID:7962098]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005628 prospore
FT                   membrane [PMID:24390141]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:17914457]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:17914457]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud
FT                   tip [PMID:17914457]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex
FT                   [PMID:17914457]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043332 mating
FT                   projection tip [PMID:17914457]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0035024
FT                   negative regulation of Rho protein signal transduction
FT                   [PMID:17914457]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin
FT                   cytoskeleton organization [PMID:7579704]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0035024 negative
FT                   regulation of Rho protein signal transduction
FT                   [PMID:17914457]"
FT                   /protein_id="DAA07816.1"
FT                   /translation="MKGLLWSKNRKSSTASASSSSTSTSHKTTTASTASSSSPSSSSQT
FT                   IRNSTSGASPYMHSHHHHGQGHSHHRGEDNNRDKRKSSVFPPSKQYTSTSSSQVNLGMY
FT                   HSDTNTRSSRSIASTLKDDSPSVCSEDEISNSSSQKSNAQDETPIAYKKSAHSKDSLLP
FT                   SRSSSLSPPQSRCSTGTTLEKSLNTSGISNSSGTNNNNSNNNNDNEQKQRNVIHLNSEN
FT                   YDTTVFKTGWVNKSHGQTVATNYNSSMTAPSSSSSSSSQNLRNDAYSRNRESRFYGNDG
FT                   SSLKNDDSSSTTATNSGNDVASARSSMAIDPQMLVPDYRLYRAQLKGCVLNLYKSGLNS
FT                   NIKFFDPTLPASNSSIANENHQQKKQQTNNQAQAEALHQKQSFGQMGEPITLDLKYLSE
FT                   VYPHPDLRQDSDGKIISGTIESLCHTVLFYPGPKQSDVPNEKSLSKTHRAVINLLLMFP
FT                   LLDHFIKFLKVFNQFGLSFTKNKSRLTNNSTQFYNISPAVDDSMTQRLALTAKTILDVF
FT                   PGFLLDEPMLKTIISLLDTISLHNDEISNNLKIKIANKHNELMKLTAFTRSLPMATSST
FT                   HELEIILDPSHFLSLDITTLADEVHHINLKFDKVWAPKFDYSLLYDSKFINRRIVSLNP
FT                   LVFNNDQNIHFLGRLLISHLFPTNPEFSKKVTPKVRAELLDKWVQIGCRFEHLGDMVSW
FT                   LAVATIICSIPVLRSSSWKYVPDQSLKTIFKDWVPTIIQLERRQRTSKSTSSVFILAPP
FT                   NLDDDFTRANVISYFGDLLIHADDLPSDTKFKYLEKKINRTKNAFHKWQQRLQAIDSTR
FT                   HKTNSTENVRDNDSPNNVVYQLWKFHLSQPPLNIEGIMKLSVQHEPPIIDQKAYSTIGS
FT                   QRSALVTGSYLPILFNELFPNYSLFPKNTLVGAASDAKLPPPRSSARLSKSLSISEPIP
FT                   IASNSHTMGSLTDDAMSSKNDNNKVTGVGKIDGPVIKEMSSKQSNKQRLLKSVRDVFNI
FT                   DMDVFHISDELVFKSVYDNDGKSRPASMVIETPKRFSQHSSMLINNPATPNQKMRDSLD
FT                   TTGRLSKTLENMDFFNNIGQVSDSLKESIIRVVLKSSSLEKIFDLLVLTSNIFSKLVDT
FT                   KDLENYYYHQRQRGHSTRGLSDDNIGLLDYAFVKLTMDNDIFTETFFNTYKSFTTTTTV
FT                   LENMAKRYVGAKSCSVSISKILDRSDDSKMKINEDTNLVSSSLYDQNFPVWDMKVTDDE
FT                   NINLIYMAKIQIGAAEAILHLVKNHYSDFTDDLCNNSTLLDIIKIMEQEVSTEWPTRIA
FT                   NSKLQKSLPENFVIETENLLTTLTDLFHGIKSAYQKQLYRPIGVNRTQKRITDILNSFN
FT                   TFSFTDLNNIIDDPSFSDDMIRSFQKLHSTNYEDILEWIYQLDNFISKKFNLVSKKDWI
FT                   VLFQELELLSKESLVSFFNYPLHFKSSKLINPGYLQLHEFEISNLFTWISTLILKDDNG
FT                   TESLFFEKLPQSIKLLIKLHTSLTTFFVMEISNVNKSSSERLTTCKVILQILNYIRWKN
FT                   GSLDLFDSEEDESPHAICPHIPAFIETAIAHAIISPESRNYELSWIKASEKLSDPTKGT
FT                   QNLRSISNVLEKIDDIHIKRFIEIDDVFSKNCKNLCPCPGWFISRLLEISQFVPNMSIT
FT                   NSKLINFDKRRFVNNIISNVLDLIPNEREFPLDIEMSDENPSKRTTFGRILFNNFEDVN
FT                   KVYRKKTKKVSESEAISERFQEQGVFNEILVNEIEKIKREARKLEVLLDQEKILKNSAA
FT                   LHQAVPKKNRKSVIISGTHSDNDHSYNINKNTGQTPSLGSVMESNNSARNRRDSRASFS
FT                   TNRSSVVSNSSHNGVSKKIGGFFRRPFSIGGFNTSSSNYSLNSILSQEVSSNKSILPSI
FT                   LPEVDSMQLHDLKPSYSLKTFEIKSIMEIINHRNIPAYYYAFKIVMQNGHEYLIQTASS
FT                   SDLTEWIKMIKASKRFSFHSKKYKGKTHNKIFGVPLEDVCERENTLIPTIVVKLLEEIE
FT                   LRGLDEVGLYRIPGSIGSINALKNAFDEEGATDNSFTLEDDRWFEVNAIAGCFKMYLRE
FT                   LPDSLFSHAMVNDFTDLAIKYKAHAMVNEEYKRMMNELLQKLPTCYYQTLKRIVFHLNK
FT                   VHQHVVNNKMDASNLAIVFSMSFINQEDLANSMGSRLGAVQTILQDFIKNPNDYFKQ"
FT   gene            complement(483325..484341)
FT                   /locus_tag="YER156C"
FT   mRNA            complement(483325..484341)
FT                   /locus_tag="YER156C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(483325..484341)
FT                   /codon_start=1
FT                   /locus_tag="YER156C"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; interacts with Hsp82p and
FT                   copurifies with Ipl1p; expression is copper responsive and
FT                   downregulated in strains deleted for MAC1, a
FT                   copper-responsive transcription factor; similarity to
FT                   mammalian MYG1"
FT                   /db_xref="GOA:P40093"
FT                   /db_xref="InterPro:IPR003226"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40093"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /protein_id="DAA07817.1"
FT                   /translation="MNSVKRVKLNSKMSKQICTHSGSFHADESLAVYMLRLLPEFKDAK
FT                   LVRSRNPKDWEASDILVDVGAQYDGVKFFDHHQRGFFETFNEKYKTKLSSAGLIFKHYG
FT                   RDIIKTILNNKVSSSDLDLLYDKVYKQFVEALDANDNGISKYTIPKDSNLEPNFRDNAI
FT                   SIPGIISGMNPNWNEDTSDESFDRCFARASEFIGGVFVTLVRGYGQSWLPAKALVAQAI
FT                   DERMDVDKSGKIIVLPQFCPWKEHLYELEREKNIEKQIEFVLFTDSSGAWRVSTVPINS
FT                   TSFQFRRGLPEPLRGLRDEELSTKSGVPGCIFIHAAGFIGGAKSKEAVYELAKMSLA"
FT   gene            484788..487193
FT                   /gene="COG3"
FT                   /gene_synonym="GRD20"
FT                   /gene_synonym="SEC34"
FT                   /locus_tag="YER157W"
FT   mRNA            484788..487193
FT                   /gene="COG3"
FT                   /gene_synonym="GRD20"
FT                   /gene_synonym="SEC34"
FT                   /locus_tag="YER157W"
FT                   /product="Golgi transport complex subunit COG3"
FT   CDS_pept        484788..487193
FT                   /codon_start=1
FT                   /gene="COG3"
FT                   /gene_synonym="GRD20"
FT                   /gene_synonym="SEC34"
FT                   /locus_tag="YER157W"
FT                   /product="Golgi transport complex subunit COG3"
FT                   /note="Essential component of the conserved oligomeric
FT                   Golgi complex; a cytosolic tethering complex (Cog1p through
FT                   Cog8p) that functions in protein trafficking to mediate
FT                   fusion of transport vesicles to Golgi compartments"
FT                   /db_xref="GOA:P40094"
FT                   /db_xref="InterPro:IPR007265"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40094"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006888
FT                   endoplasmic reticulum to Golgi vesicle-mediated transport
FT                   [PMID:10512869]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000301
FT                   retrograde transport, vesicle recycling within Golgi
FT                   [PMID:11703943]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006891
FT                   intra-Golgi vesicle-mediated transport [PMID:11703943]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016236
FT                   macroautophagy [PMID:20065092]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi
FT                   transport complex [PMID:11703943]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030242
FT                   autophagy of peroxisome [PMID:20065092]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0032258 protein
FT                   localization by the Cvt pathway [PMID:20065092]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0140312 cargo
FT                   adaptor activity [PMID:15229219]"
FT                   /protein_id="DAA07818.1"
FT                   /translation="MARSRKNSLVRDIASHPTIPESQTIVGLLDDSYLFDKLKKLSLAV
FT                   ENSDSLQRTDVSEGCSEVNGSEATTSADVKKTNKYLYYTTYLDQLNIKIDEYKVVLDQT
FT                   RQVNDQLDSSIKKFRKISQDTGAFIEETKTIYEKQSKLSNLTESIPKALHYFEVLDPIM
FT                   RRLNHATSPAIVKKSSFTTMLATIDESLRFLDENSDLKDAAAYRIKFKQCLIRACELIS
FT                   HFLTNLLKQTNQEILDKTKNKNSLTGLPSTTRDAFLYSKFYTIADTFKIQVSEIVKRSN
FT                   EKAYNKYHDELNSILYECFNHYFQTRLRLLTPVIWSHIDEIVVKDKDQGLVKFIQDGKV
FT                   YFQQLCADEYKLFVEFFPEKECRFKINQWFLQLCEPLYDSIRVRVLKETDICTLCDSVT
FT                   LFAPYYEFEEGSEEYVKQFTDIQYDKLFEPIVQKVQARLILRVQIYVQQNILSYRPTRD
FT                   VFMISNRRRKSKTSLQGGNEDATTSDDNPDPLLESYLSSFKNRSILPISPNDADDKSID
FT                   SEESTDKISQLQTYYPPLLKTLALLSKIYEMINSVVFDDLAHHVVHDCIVSLRNAYDMV
FT                   IKSSAGKSDFNNLDISLAYLKNLLMLRDSIQNFNIQYTVNETYLDFSGVEGFFKSLKEN
FT                   GRNVLKKTKSSSILTLARELVPKVVNNMVDARTELISELRNVIKDFTESTSLELIDDTL
FT                   DINSDEDLLSKNVKLRENIKARLPRIYEQILNYIDDQEIVTNLLDAVQELITQSYSKYY
FT                   ETITELAENGKFAKDQVADVMYLDVFTDFFAKEVADLLRNGDIDTITK"
FT   gene            complement(487331..487402)
FT                   /locus_tag="tE(UUC)E3"
FT   tRNA            complement(487331..487402)
FT                   /locus_tag="tE(UUC)E3"
FT                   /product="tRNA-Glu"
FT                   /note="tE(UUC)E3; Glutamate tRNA (tRNA-Glu), predicted by
FT                   tRNAscan-SE analysis; thiolation of uridine at wobble
FT                   position (34) requires Ncs6p; target of K. lactis zymocin"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   repeat_region   487834..488165
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            complement(488857..490578)
FT                   /locus_tag="YER158C"
FT   mRNA            complement(488857..490578)
FT                   /locus_tag="YER158C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(488857..490578)
FT                   /codon_start=1
FT                   /locus_tag="YER158C"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; potentially phosphorylated by
FT                   Cdc28p; YER158C has a paralog, AFR1, that arose from the
FT                   whole genome duplication"
FT                   /db_xref="GOA:P40095"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40095"
FT                   /protein_id="DAA07819.1"
FT                   /translation="MLQQGSSSRRSLHGNDFHTLTSPSRRDSLSIPRAVDARSASTIDL
FT                   FYIPDATVSRRHSTLVANRSDNNGNGAPMRQYNKPNFASSSTSSLPSTRNRPSRYDNMN
FT                   MNMNMNMNMNMNMNMNMNNHTTSDHNAHPQYRCRPNPSRRHSLMTIPEKYSGSRYSLRS
FT                   SPPTYSNPRVRKELTPFQLQRKQMKSAFQFPNGENFTPRNQIARLPPSSTFPDSPSSSS
FT                   LPLTQTGGPSSADNDSIATGTNNRSPQQTKAADANQKSESESPKAIRSNSKKISRFFRK
FT                   IWSSKSSNSADSVEENSKTKQKRKNPERVVPEPITSLDQPVEIIKQSFSTVNNHETAVP
FT                   SIKDSGIVQELTALGDNNRIPVLPPPRSPNRPTLSDKRTTKLYYCSQDSSNEDIAPEEK
FT                   STVFLKRLQDEWSTVYLNKLPLTASVPSSLSTTTDAANSSFINSSISSPAPSSSSSSSL
FT                   VSRGPMQSISSSPTPAPSSGSSKSKNAVKSLRFADEIYVNDTWSAADYCRCDNTFLNNF
FT                   FKGKSQDITNPSTFVGNNLSSTKNISNIEIKMEVNEFKRKEMRVHQDSAKYTHYYL"
FT   gene            complement(491530..491958)
FT                   /gene="BUR6"
FT                   /gene_synonym="NCB1"
FT                   /locus_tag="YER159C"
FT   mRNA            complement(491530..491958)
FT                   /gene="BUR6"
FT                   /gene_synonym="NCB1"
FT                   /locus_tag="YER159C"
FT                   /product="negative cofactor 2 transcription regulator
FT                   complex subunit BUR6"
FT   CDS_pept        complement(491530..491958)
FT                   /codon_start=1
FT                   /gene="BUR6"
FT                   /gene_synonym="NCB1"
FT                   /locus_tag="YER159C"
FT                   /product="negative cofactor 2 transcription regulator
FT                   complex subunit BUR6"
FT                   /note="Subunit of a heterodimeric NC2 transcription
FT                   regulator complex; complex binds to TBP and can repress
FT                   transcription by preventing preinitiation complex assembly
FT                   or stimulate activated transcription; homologous to human
FT                   NC2alpha; complex also includes Ncb2p; bur6 ncb2 double
FT                   mutation is functionally complemented by coexpression of
FT                   human DRAP1 and DR1, although the single bur6 mutation is
FT                   not complemented by its ortholog DRAP1"
FT                   /db_xref="GOA:P40096"
FT                   /db_xref="InterPro:IPR003958"
FT                   /db_xref="InterPro:IPR009072"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40096"
FT                   /experiment="EXISTENCE:direct assay:GO:0000122 negative
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:8948634|PMID:9023340|PMID:9096360]"
FT                   /experiment="EXISTENCE:direct assay:GO:0001047 core
FT                   promoter binding [PMID:18703679]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003682 chromatin
FT                   binding [PMID:18703679]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003713
FT                   transcription coactivator activity [PMID:12237409]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003714
FT                   transcription corepressor activity [PMID:9023340]"
FT                   /experiment="EXISTENCE:direct assay:GO:0017054 negative
FT                   cofactor 2 complex [PMID:8948634]"
FT                   /experiment="EXISTENCE:direct assay:GO:0045944 positive
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:12237409]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000122
FT                   negative regulation of transcription by RNA polymerase II
FT                   [PMID:10713169]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0003714
FT                   transcription corepressor activity [PMID:10713169]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:10713169]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003714
FT                   transcription corepressor activity [PMID:10713169]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA
FT                   polymerase II preinitiation complex assembly
FT                   [PMID:18048413]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0061408 positive
FT                   regulation of transcription from RNA polymerase II promoter
FT                   in response to heat stress [PMID:18048413]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0017025
FT                   TBP-class protein binding [PMID:9096360]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0017054
FT                   negative cofactor 2 complex [PMID:9023340]"
FT                   /protein_id="DAA07820.1"
FT                   /translation="MADQVPVTTQLPPIKPEHEVPLDAGGSPVGNMGTNSNNNNELGDV
FT                   FDRIKTHFPPAKVKKIMQTDEDIGKVSQATPVIAGRSLEFFIALLVKKSGEMARGQGTK
FT                   RITAEILKKTILNDEKFDFLREGLCVEEGQTQPEEESA"
FT   gene            complement(492352..492424)
FT                   /locus_tag="tR(ACG)E"
FT   tRNA            complement(492352..492424)
FT                   /locus_tag="tR(ACG)E"
FT                   /product="tRNA-Arg"
FT                   /note="tR(ACG)E; Arginine tRNA (tRNA-Arg), predicted by
FT                   tRNAscan-SE analysis; one of 6 nuclear tRNA genes
FT                   containing the tDNA-anticodon ACG (converted to ICG in the
FT                   mature tRNA), decodes CGU, CGC, and probably CGA codons
FT                   into arginine, one of 19 nuclear tRNAs for arginine"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   mobile_element  complement(492695..498421)
FT                   /mobile_element_type="retrotransposon:YERCTy1-2"
FT                   /note="YERCTy1-2; Ty1 element, LTR retrotransposon of the
FT                   Copia (Pseudoviridae) group; contains co-transcribed genes
FT                   TYA Gag and TYB Pol, encoding proteins involved in
FT                   structure and function of virus-like particles, flanked by
FT                   two direct repeats"
FT   repeat_region   complement(492695..492833)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            complement(492856..498124)
FT                   /locus_tag="YER160C"
FT   mRNA            complement(492856..498124)
FT                   /locus_tag="YER160C"
FT                   /product="gag-pol fusion protein"
FT   CDS_pept        complement(join(492856..496821,496823..498124))
FT                   /codon_start=1
FT                   /ribosomal_slippage
FT                   /locus_tag="YER160C"
FT                   /product="gag-pol fusion protein"
FT                   /EC_number="2.7.7.49"
FT                   /EC_number="3.1.26.4"
FT                   /EC_number="2.7.7.7"
FT                   /note="Retrotransposon TYA Gag and TYB Pol genes;
FT                   transcribed/translated as one unit; polyprotein is
FT                   processed to make a nucleocapsid-like protein (Gag),
FT                   reverse transcriptase (RT), protease (PR), and integrase
FT                   (IN); similar to retroviral genes"
FT                   /db_xref="GOA:Q03619"
FT                   /db_xref="InterPro:IPR001584"
FT                   /db_xref="InterPro:IPR001969"
FT                   /db_xref="InterPro:IPR012337"
FT                   /db_xref="InterPro:IPR013103"
FT                   /db_xref="InterPro:IPR015820"
FT                   /db_xref="InterPro:IPR036397"
FT                   /db_xref="InterPro:IPR039537"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q03619"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:9448009]"
FT                   /protein_id="DAA07821.1"
FT                   /translation="MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDK
FT                   ASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFY
FT                   GHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMT
FT                   STKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYN
FT                   TFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGST
FT                   PADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELF
FT                   LDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTAR
FT                   AHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLGQKLTESTVNHTNHSDDELPGHL
FT                   LLDSGASRTLIRSAHHIHSASSNPDINVVDAQKRNIPINAIGDLQFHFQDNTKTSIKVL
FT                   HTPNIAYDLLSLNELAAVDITACFTKNVLERSDGTVLAPIVKYGDFYWVSKKYLLPSNI
FT                   SVPTINNVHTSESTRKYPYPFIHRMLAHANAQTIRYSLKNNTITYFNESDVDWSSAIDY
FT                   QCPDCLIGKSTKHRHIKGSRLKYQNSYEPFQYLHTDIFGPVHNLPKSAPSYFISFTDET
FT                   TKFRWVYPLHDRREDSILDVFTTILAFIKNQFQASVLVIQMDRGSEYTNRTLHKFLEKN
FT                   GITPCYTTTADSRAHGVAERLNRTLLDDCRTQLQCSGLPNHLWFSAIEFSTIVRNSLAS
FT                   PKSKKSARQHAGLAGLDISTLLPFGQPVIVNDHNPNSKIHPRGIPGYALHPSRNSYGYI
FT                   IYLPSLKKTVDTTNYVILQGKESRLDQFNYDALTFDEDLNRLTASYHSFIASNEIQQSN
FT                   DLNIESDHDFQSDIELHPEQLRNVLSKAVSPTDSTPPSTHTEDSKRVSKTNIRAPREVD
FT                   PNISESNILPSKKRSSTPQISDIESTGSGGMHRLDVPLLAPMSQSNTHESSHASKSKDF
FT                   RHSDSYSDNETNHTNVPISSTGGTNNKTVPQTSEQETEKRIIHRSPSIDTSSSESNSLH
FT                   HVVPIKTSDTCPKENTEESIIADLPLPDLPPEPPTELSDSFKELPPINSHQTNSSLGGI
FT                   GDSNAYTTINSKKRSLEDNETEIKVSRDTWNTKNMRSLEPPRSKKRIHLIAAVKAVKSI
FT                   KPIRTTLRYDEAITYNKDIKEKEKYIQAYHKEVNQLLKMKTWDTDRYYDRKEIDPKRVI
FT                   NSMFIFNRKRDGTHKARFVARGDIQHPDTYDPGMQSNTVHHYALMTSLSLALDNNYYIT
FT                   QLDISSAYLYADIKEELYIRPPPHLGMNDKLIRLKKSLYGLKQSGANWYETIKSYLIKQ
FT                   CGMEEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIINLGESD
FT                   NEIQYDILGLEIKYQRGKYMKLGMENSLTEKIPKLNVPLNPKGRKLSAPGQPGLYIDQQ
FT                   ELELEEDDYKMKVHEMQKLIGLASYVGYKFRFDLLYYINTLAQHILFPSKQVLDMTYEL
FT                   IQFIWNTRDKQLIWHKSKPVKPTNKLVVISDASYGNQPYYKSQIGNIYLLNGKVIGGKS
FT                   TKASLTCTSTTEAEIHAISESVPLLNNLSHLVQELNKKPITKGLLTDSKSTISIIISNN
FT                   EEKFRNRFFGTKAMRLRDEVSGNHLHVCYIETKKNIADVMTKPLPIKTFKLLTNKWIH"
FT   gene            complement(496802..498124)
FT                   /locus_tag="YER159C-A"
FT   mRNA            complement(496802..498124)
FT                   /locus_tag="YER159C-A"
FT                   /product="gag protein"
FT   CDS_pept        complement(496802..498124)
FT                   /codon_start=1
FT                   /locus_tag="YER159C-A"
FT                   /product="gag protein"
FT                   /note="Retrotransposon TYA Gag gene co-transcribed with TYB
FT                   Pol; translated as TYA or TYA-TYB polyprotein; Gag is a
FT                   nucleocapsid protein that is the structural constituent of
FT                   virus-like particles (VLPs); similar to retroviral Gag"
FT                   /db_xref="GOA:P0CX66"
FT                   /db_xref="InterPro:IPR015820"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CX66"
FT                   /protein_id="DAA07822.1"
FT                   /translation="MESQQLSNYPHISHGSACASVTSKEVHTNQDPLDVSASKIQEYDK
FT                   ASTKANSQQTTTPASSAVPENPHHASPQPASVPPPQNGPYPQQCMMTQNQANPSGWSFY
FT                   GHPSMIPYTPYQMSPMYFPPGPQSQFPQYPSSVGTPLSTPSPESGNTFTDSSSADSDMT
FT                   STKKYVRPPPMLTSPNDFPNWVKTYIKFLQNSNLGGIIPTVNGKPVRQITDDELTFLYN
FT                   TFQIFAPSQFLPTWVKDILSVDYTDIMKILSKSIEKMQSDTQEANDIVTLANLQYNGST
FT                   PADAFETKVTNIIDRLNNNGIHINNKVACQLIMRGLSGEYKFLRYTRHRHLNMTVAELF
FT                   LDIHAIYEEQQGSRNSKPNYRRNPSDEKNDSRSYTNTTKPKVIARNPQKTNNSKSKTAR
FT                   AHNVSTSNNSPSTDNDSISKSTTEPIQLNNKHDLHLRPETY"
FT   repeat_region   complement(498084..498421)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   rep_origin      498884..499182
FT                   /note="ARS520; Autonomously Replicating Sequence"
FT   gene            complement(499347..500348)
FT                   /gene="SPT2"
FT                   /gene_synonym="EXA1"
FT                   /gene_synonym="SIN1"
FT                   /locus_tag="YER161C"
FT   mRNA            complement(499347..500348)
FT                   /gene="SPT2"
FT                   /gene_synonym="EXA1"
FT                   /gene_synonym="SIN1"
FT                   /locus_tag="YER161C"
FT                   /product="Spt2p"
FT   CDS_pept        complement(499347..500348)
FT                   /codon_start=1
FT                   /gene="SPT2"
FT                   /gene_synonym="EXA1"
FT                   /gene_synonym="SIN1"
FT                   /locus_tag="YER161C"
FT                   /product="Spt2p"
FT                   /note="Protein involved in negative regulation of
FT                   transcription; required for RNA polyadenylation; exhibits
FT                   regulated interactions with both histones and SWI-SNF
FT                   components; relocalizes to the cytosol in response to
FT                   hypoxia; similar to mammalian HMG1 proteins"
FT                   /db_xref="GOA:P06843"
FT                   /db_xref="InterPro:IPR013256"
FT                   /db_xref="UniProtKB/Swiss-Prot:P06843"
FT                   /experiment="EXISTENCE:direct assay:GO:0000217 DNA
FT                   secondary structure binding [PMID:15563464]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
FT                   [PMID:2072912]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:2072912|PMID:22932476]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:22932476]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006368
FT                   transcription elongation from RNA polymerase II promoter
FT                   [PMID:16449659]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0043631 RNA
FT                   polyadenylation [PMID:16788068]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:17526727]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006325
FT                   chromatin organization [PMID:16449659|PMID:19057669]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043631 RNA
FT                   polyadenylation [PMID:16788068]"
FT                   /protein_id="DAA07823.1"
FT                   /translation="MSFLSKLSQIRKSTTASKAQVQDPLPKKNDEEYSLLPKNYIRDED
FT                   PAVKRLKELRRQELLKNGALAKKSGVKRKRGTSSGSEKKKIERNDDDEGGLGIRFKRSI
FT                   GASHAPLKPVVRKKPEPIKKMSFEELMKQAENNEKQPPKVKSSEPVTKERPHFNKPGFK
FT                   SSKRPQKKASPGATLRGVSSGGNSIKSSDSPKPVKLNLPTNGFAQPNRRLKEKLESRKQ
FT                   KSRYQDDYDEEDNDMDDFIEDDEDEGYHSKSKHSNGPGYDRDEIWAMFNRGKKRSEYDY
FT                   DELEDDDMEANEMEILEEEEMARKMARLEDKREEAWLKKHEEEKRRRKKGIR"
FT   gene            complement(500630..502894)
FT                   /gene="RAD4"
FT                   /locus_tag="YER162C"
FT   mRNA            complement(500630..502894)
FT                   /gene="RAD4"
FT                   /locus_tag="YER162C"
FT                   /product="Rad4p"
FT   CDS_pept        complement(500630..502894)
FT                   /codon_start=1
FT                   /gene="RAD4"
FT                   /locus_tag="YER162C"
FT                   /product="Rad4p"
FT                   /note="Protein that recognizes and binds damaged DNA (with
FT                   Rad23p) during NER; subunit of Nuclear Excision Repair
FT                   Factor 2 (NEF2); also involved, with Rad23p, in turnover of
FT                   ubiquitylated proteins; Rad4p-Rad23p heterodimer binds to
FT                   promoters of DNA damage response genes to repress their
FT                   transcription in the absence of DNA damage; NER stands for
FT                   nucleotide excision repair"
FT                   /db_xref="GOA:P14736"
FT                   /db_xref="InterPro:IPR004583"
FT                   /db_xref="InterPro:IPR018325"
FT                   /db_xref="InterPro:IPR018326"
FT                   /db_xref="InterPro:IPR018327"
FT                   /db_xref="InterPro:IPR018328"
FT                   /db_xref="InterPro:IPR036985"
FT                   /db_xref="InterPro:IPR038765"
FT                   /db_xref="InterPro:IPR042488"
FT                   /db_xref="PDB:2M14"
FT                   /db_xref="PDB:2QSF"
FT                   /db_xref="PDB:2QSG"
FT                   /db_xref="PDB:2QSH"
FT                   /db_xref="PDB:4YIR"
FT                   /db_xref="PDB:6CFI"
FT                   /db_xref="UniProtKB/Swiss-Prot:P14736"
FT                   /experiment="EXISTENCE:direct assay:GO:0000111
FT                   nucleotide-excision repair factor 2 complex [PMID:7768886]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA
FT                   binding [PMID:9813069|PMID:9837874]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:19889839]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:19889839]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006265 DNA
FT                   topological change [PMID:27035942]"
FT                   /experiment="EXISTENCE:direct assay:GO:1990165
FT                   single-strand break-containing DNA binding [PMID:27035942]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:26150418]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006289
FT                   nucleotide-excision repair [PMID:18936173]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043161
FT                   proteasome-mediated ubiquitin-dependent protein catabolic
FT                   process [PMID:19889839]"
FT                   /protein_id="DAA07824.2"
FT                   /translation="MNEDLPKEYFELIRKALNEKEAEKAPLSRRRRVRRKNQPLPDAKK
FT                   KFKTGLNELPRESVVTVNLDSSDDGVVTVPTDDSVEEIQSSEEDYDSEEFEDVTDGNEV
FT                   AGVEDISVEIKPSSKRNSDARRTSRNVCSNEERKRRKYFHMLYLVCLMVHGFIRNEWIN
FT                   SKRLSRKLSNLVPEKVFELLHPQKDEELPLRSTRKLLDGLKKCMELWQKHWKITKKYDN
FT                   VGLYMRTWKEIEMSANNKRKFKTLKRSDFLRAVSKGHGDPDISVQGFVAMLRACNVNAR
FT                   LIMSCQPPDFTNMKIDTSLNGNNAYKDMVKYPIFWCEVWDKFSKKWITVDPVNLKTIEQ
FT                   VRLHSKLAPKGVACCERNMLRYVIAYDRKYGCRDVTRRYAQWMNSKVRKRRITKDDFGE
FT                   KWFRKVITALHHRKRTKIDDYEDQYFFQRDESEGIPDSVQDLKNHPYYVLEQDIKQTQI
FT                   VKPGCKECGYLKVHGKVGKVLKVYAKRDIADLKSARQWYMNGRILKTGSRCKKVIKRTV
FT                   GRPKGEAEEEDERLYSFEDTELYIPPLASASGEITKNTFGNIEVFAPTMIPGNCCLVEN
FT                   PVAIKAARFLGVEFAPAVTSFKFERGSTVKPVLSGIVVAKWLREAIETAIDGIEFIQED
FT                   DNRKEHLLGALESWNTLLLKLRIRSKLNSTYGKIAEEEPNVTKEQNIADNHDNTETFMG
FT                   GGFLPGIANHEARPYSEPSEPEDSLDYVSVDKAEESATDDDVGEDYSDFMKELEMSEES
FT                   D"
FT   gene            complement(503084..503782)
FT                   /gene="GCG1"
FT                   /locus_tag="YER163C"
FT   mRNA            complement(503084..503782)
FT                   /gene="GCG1"
FT                   /locus_tag="YER163C"
FT                   /product="gamma-glutamylcyclotransferase"
FT   CDS_pept        complement(503084..503782)
FT                   /codon_start=1
FT                   /gene="GCG1"
FT                   /locus_tag="YER163C"
FT                   /product="gamma-glutamylcyclotransferase"
FT                   /EC_number="4.3.2.7"
FT                   /note="Gamma-glutamyl cyclotransferase; cleaves the
FT                   gamma-glutamyl bond of glutathione to yield 5-oxoproline
FT                   and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic
FT                   protein ChaC1; expression of mouse ChaC1 in yeast increases
FT                   apoptosis; green fluorescent protein (GFP)-fusion protein
FT                   localizes to the cytoplasm and nucleus; periodically
FT                   expressed during the metabolic cycle"
FT                   /db_xref="GOA:P32656"
FT                   /db_xref="InterPro:IPR006840"
FT                   /db_xref="InterPro:IPR013024"
FT                   /db_xref="PDB:5HWI"
FT                   /db_xref="PDB:5HWK"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32656"
FT                   /experiment="EXISTENCE:direct assay:GO:0003839
FT                   gamma-glutamylcyclotransferase activity [PMID:23070364]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006751 glutathione
FT                   catabolic process [PMID:23070364]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006751
FT                   glutathione catabolic process [PMID:23070364]"
FT                   /protein_id="DAA07825.1"
FT                   /translation="MTNDNSGIWVLGYGSLIYKPPSHYTHRIPAIIHGFARRFWQSSTD
FT                   HRGTPANPGRVATLIPYEDIIRQTAFLKNVNLYSESAPIQDPDDLVTIGVVYYIPPEHA
FT                   QEVREYLNVREQNGYTLHEVEVHLETNREHEAELGEALEQLPRHNKSGKRVLLTSVYIG
FT                   TIDNEAFVGPETVDETAKVIAVSHGPSGSNYEYLAKLEQALAQMPIMKERGRITDHYLT
FT                   ALLETVNKYR"
FT   gene            505392..509798
FT                   /gene="CHD1"
FT                   /locus_tag="YER164W"
FT   mRNA            505392..509798
FT                   /gene="CHD1"
FT                   /locus_tag="YER164W"
FT                   /product="chromatin-remodeling ATPase CHD1"
FT   CDS_pept        505392..509798
FT                   /codon_start=1
FT                   /gene="CHD1"
FT                   /locus_tag="YER164W"
FT                   /product="chromatin-remodeling ATPase CHD1"
FT                   /note="Chromatin remodeler that regulates various aspects
FT                   of transcription; acts in in conjunction with Isw1b to
FT                   regulate chromatin structure and maintain chromatin
FT                   integrity during transcription elongation by RNAP II by
FT                   preventing trans-histone exchange over coding regions;
FT                   contains a chromo domain, a helicase domain and a
FT                   DNA-binding domain; component of both the SAGA and SLIK
FT                   complexes"
FT                   /db_xref="GOA:P32657"
FT                   /db_xref="InterPro:IPR000330"
FT                   /db_xref="InterPro:IPR000953"
FT                   /db_xref="InterPro:IPR001650"
FT                   /db_xref="InterPro:IPR009057"
FT                   /db_xref="InterPro:IPR014001"
FT                   /db_xref="InterPro:IPR016197"
FT                   /db_xref="InterPro:IPR023779"
FT                   /db_xref="InterPro:IPR023780"
FT                   /db_xref="InterPro:IPR025260"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR038718"
FT                   /db_xref="InterPro:IPR041150"
FT                   /db_xref="PDB:2DY7"
FT                   /db_xref="PDB:2DY8"
FT                   /db_xref="PDB:2H1E"
FT                   /db_xref="PDB:2XB0"
FT                   /db_xref="PDB:3MWY"
FT                   /db_xref="PDB:3TED"
FT                   /db_xref="PDB:5J70"
FT                   /db_xref="PDB:5O9G"
FT                   /db_xref="PDB:6FTX"
FT                   /db_xref="PDB:6G0L"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32657"
FT                   /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex
FT                   [PMID:15647753]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding
FT                   [PMID:17259992]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000790 nuclear
FT                   chromatin [PMID:12504018|PMID:12682017]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding
FT                   [PMID:21623345]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008094
FT                   DNA-dependent ATPase activity [PMID:10811623]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016584 nucleosome
FT                   positioning [PMID:17949749]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030874 nucleolar
FT                   chromatin [PMID:17259992]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031490 chromatin
FT                   DNA binding [PMID:12682017]"
FT                   /experiment="EXISTENCE:direct assay:GO:0035064 methylated
FT                   histone binding [PMID:15647753]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042766 nucleosome
FT                   mobilization [PMID:16606615]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043044
FT                   ATP-dependent chromatin remodeling [PMID:10811623]"
FT                   /experiment="EXISTENCE:direct assay:GO:0044212
FT                   transcription regulatory region DNA binding
FT                   [PMID:23468649]"
FT                   /experiment="EXISTENCE:direct assay:GO:0046695 SLIK
FT                   (SAGA-like) complex [PMID:15647753]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070615
FT                   nucleosome-dependent ATPase activity [PMID:10811623]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0001178
FT                   regulation of transcriptional start site selection at RNA
FT                   polymerase II promoter [PMID:19948887]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006363
FT                   termination of RNA polymerase I transcription
FT                   [PMID:17259992]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006368
FT                   transcription elongation from RNA polymerase II promoter
FT                   [PMID:12682017]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006369
FT                   termination of RNA polymerase II transcription
FT                   [PMID:12504018]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0060303
FT                   regulation of nucleosome density [PMID:16468993]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:2000104
FT                   negative regulation of DNA-dependent DNA replication
FT                   [PMID:18245327]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006369
FT                   termination of RNA polymerase II transcription
FT                   [PMID:12504018]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034728
FT                   nucleosome organization [PMID:10811623]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0071441 negative
FT                   regulation of histone H3-K14 acetylation [PMID:19948887]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0071894 histone
FT                   H2B conserved C-terminal lysine ubiquitination
FT                   [PMID:22549955]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1900050 negative
FT                   regulation of histone exchange [PMID:22922743]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:1902275
FT                   regulation of chromatin organization [PMID:22922743]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000616 negative
FT                   regulation of histone H3-K9 acetylation [PMID:19948887]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0006368
FT                   transcription elongation from RNA polymerase II promoter
FT                   [PMID:12682017]"
FT                   /protein_id="DAA07826.1"
FT                   /translation="MAAKDISTEVLQNPELYGLRRSHRAAAHQQNYFNDSDDEDDEDNI
FT                   KQSRRKRMTTIEDDEDEFEDEEGEEDSGEDEDEEDFEEDDDYYGSPIKQNRSKPKSRTK
FT                   SKSKSKPKSQSEKQSTVKIPTRFSNRQNKTVNYNIDYSDDDLLESEDDYGSEEALSEEN
FT                   VHEASANPQPEDFHGIDIVINHRLKTSLEEGKVLEKTVPDLNNCKENYEFLIKWTDESH
FT                   LHNTWETYESIGQVRGLKRLDNYCKQFIIEDQQVRLDPYVTAEDIEIMDMERERRLDEF
FT                   EEFHVPERIIDSQRASLEDGTSQLQYLVKWRRLNYDEATWENATDIVKLAPEQVKHFQN
FT                   RENSKILPQYSSNYTSQRPRFEKLSVQPPFIKGGELRDFQLTGINWMAFLWSKGDNGIL
FT                   ADEMGLGKTVQTVAFISWLIFARRQNGPHIIVVPLSTMPAWLDTFEKWAPDLNCICYMG
FT                   NQKSRDTIREYEFYTNPRAKGKKTMKFNVLLTTYEYILKDRAELGSIKWQFMAVDEAHR
FT                   LKNAESSLYESLNSFKVANRMLITGTPLQNNIKELAALVNFLMPGRFTIDQEIDFENQD
FT                   EEQEEYIHDLHRRIQPFILRRLKKDVEKSLPSKTERILRVELSDVQTEYYKNILTKNYS
FT                   ALTAGAKGGHFSLLNIMNELKKASNHPYLFDNAEERVLQKFGDGKMTRENVLRGLIMSS
FT                   GKMVLLDQLLTRLKKDGHRVLIFSQMVRMLDILGDYLSIKGINFQRLDGTVPSAQRRIS
FT                   IDHFNSPDSNDFVFLLSTRAGGLGINLMTADTVVIFDSDWNPQADLQAMARAHRIGQKN
FT                   HVMVYRLVSKDTVEEEVLERARKKMILEYAIISLGVTDGNKYTKKNEPNAGELSAILKF
FT                   GAGNMFTATDNQKKLEDLNLDDVLNHAEDHVTTPDLGESHLGGEEFLKQFEVTDYKADI
FT                   DWDDIIPEEELKKLQDEEQKRKDEEYVKEQLEMMNRRDNALKKIKNSVNGDGTAANSDS
FT                   DDDSTSRSSRRRARANDMDSIGESEVRALYKAILKFGNLKEILDELIADGTLPVKSFEK
FT                   YGETYDEMMEAAKDCVHEEEKNRKEILEKLEKHATAYRAKLKSGEIKAENQPKDNPLTR
FT                   LSLKKREKKAVLFNFKGVKSLNAESLLSRVEDLKYLKNLINSNYKDDPLKFSLGNNTPK
FT                   PVQNWSSNWTKEEDEKLLIGVFKYGYGSWTQIRDDPFLGITDKIFLNEVHNPVAKKSAS
FT                   SSDTTPTPSKKGKGITGSSKKVPGAIHLGRRVDYLLSFLRGGLNTKSPSADIGSKKLPT
FT                   GPSKKRQRKPANHSKSMTPEITSSEPANGPPSKRMKALPKGPAALINNTRLSPNSPTPP
FT                   LKSKVSRDNGTRQSSNPSSGSAHEKEYDSMDEEDCRHTMSAIRTSLKRLRRGGKSLDRK
FT                   EWAKILKTELTTIGNHIESQKGSSRKASPEKYRKHLWSYSANFWPADVKSTKLMAMYDK
FT                   ITESQKK"
FT   gene            510373..512106
FT                   /gene="PAB1"
FT                   /locus_tag="YER165W"
FT   mRNA            510373..512106
FT                   /gene="PAB1"
FT                   /locus_tag="YER165W"
FT                   /product="polyadenylate-binding protein"
FT   CDS_pept        510373..512106
FT                   /codon_start=1
FT                   /gene="PAB1"
FT                   /locus_tag="YER165W"
FT                   /product="polyadenylate-binding protein"
FT                   /note="Poly(A) binding protein; interacts with the cleavage
FT                   factor complex CF I, mediates interactions between the 5'
FT                   cap structure and the 3' mRNA poly(A) tail, involved in
FT                   control of poly(A) tail length, interacts with translation
FT                   factor eIF-4G; stimulates, but is not required for the
FT                   deadenylation activity of the Pan2p-Pan3p
FT                   poly(A)-ribonuclease complex"
FT                   /db_xref="GOA:P04147"
FT                   /db_xref="InterPro:IPR000504"
FT                   /db_xref="InterPro:IPR002004"
FT                   /db_xref="InterPro:IPR003954"
FT                   /db_xref="InterPro:IPR006515"
FT                   /db_xref="InterPro:IPR012677"
FT                   /db_xref="InterPro:IPR035979"
FT                   /db_xref="InterPro:IPR036053"
FT                   /db_xref="PDB:1IFW"
FT                   /db_xref="PDB:6R5K"
FT                   /db_xref="UniProtKB/Swiss-Prot:P04147"
FT                   /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding
FT                   [PMID:23222640]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:15630021|PMID:15769879|PMID:11914276]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:15630021|PMID:15769879|PMID:11914276]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005840 ribosome
FT                   [PMID:8631901]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006446 regulation
FT                   of translational initiation [PMID:10357826]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008143 poly(A)
FT                   binding [PMID:9193001]"
FT                   /experiment="EXISTENCE:direct assay:GO:0008428 ribonuclease
FT                   inhibitor activity [PMID:11889048]"
FT                   /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
FT                   stress granule
FT                   [PMID:17908917|PMID:18981231|PMID:19470581|PMID:24291094|P
FT                   MID:26777405]"
FT                   /experiment="EXISTENCE:direct assay:GO:0060211 regulation
FT                   of nuclear-transcribed mRNA poly(A) tail shortening
FT                   [PMID:17766253]"
FT                   /experiment="EXISTENCE:direct assay:GO:1990841
FT                   promoter-specific chromatin binding [PMID:27184763]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006446
FT                   regulation of translational initiation [PMID:10357826]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0008143 poly(A)
FT                   binding [PMID:9193001]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0060211
FT                   regulation of nuclear-transcribed mRNA poly(A) tail
FT                   shortening [PMID:17766253]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0034236
FT                   protein kinase A catalytic subunit binding [PMID:22899713]"
FT                   /protein_id="DAA07827.1"
FT                   /translation="MADITDKTAEQLENLNIQDDQKQAATGSESQSVENSSASLYVGDL
FT                   EPSVSEAHLYDIFSPIGSVSSIRVCRDAITKTSLGYAYVNFNDHEAGRKAIEQLNYTPI
FT                   KGRLCRIMWSQRDPSLRKKGSGNIFIKNLHPDIDNKALYDTFSVFGDILSSKIATDENG
FT                   KSKGFGFVHFEEEGAAKEAIDALNGMLLNGQEIYVAPHLSRKERDSQLEETKAHYTNLY
FT                   VKNINSETTDEQFQELFAKFGPIVSASLEKDADGKLKGFGFVNYEKHEDAVKAVEALND
FT                   SELNGEKLYVGRAQKKNERMHVLKKQYEAYRLEKMAKYQGVNLFVKNLDDSVDDEKLEE
FT                   EFAPYGTITSAKVMRTENGKSKGFGFVCFSTPEEATKAITEKNQQIVAGKPLYVAIAQR
FT                   KDVRRSQLAQQIQARNQMRYQQATAAAAAAAAGMPGQFMPPMFYGVMPPRGVPFNGPNP
FT                   QQMNPMGGMPKNGMPPQFRNGPVYGVPPQGGFPRNANDNNQFYQQKQRQALGEQLYKKV
FT                   SAKTSNEEAAGKITGMILDLPPQEVFPLLESDELFEQHYKEASAAYESFKKEQEQQTEQ
FT                   A"
FT   gene            512744..517459
FT                   /gene="DNF1"
FT                   /locus_tag="YER166W"
FT   mRNA            512744..517459
FT                   /gene="DNF1"
FT                   /locus_tag="YER166W"
FT                   /product="aminophospholipid-translocating P4-type ATPase
FT                   DNF1"
FT   CDS_pept        512744..517459
FT                   /codon_start=1
FT                   /gene="DNF1"
FT                   /locus_tag="YER166W"
FT                   /product="aminophospholipid-translocating P4-type ATPase
FT                   DNF1"
FT                   /EC_number="7.6.2.1"
FT                   /note="Aminophospholipid translocase (flippase); type 4
FT                   P-type ATPase; involved in phospholipid translocation,
FT                   contributing to endocytosis, protein transport, and
FT                   cellular polarization; localizes primarily to the plasma
FT                   membrane; localizes to the shmoo tip where it has a
FT                   redundant role in the cellular response to mating
FT                   pheromone; DNF1 has a paralog, DNF2, that arose from the
FT                   whole genome duplication"
FT                   /db_xref="GOA:P32660"
FT                   /db_xref="InterPro:IPR001757"
FT                   /db_xref="InterPro:IPR006539"
FT                   /db_xref="InterPro:IPR008250"
FT                   /db_xref="InterPro:IPR018303"
FT                   /db_xref="InterPro:IPR023298"
FT                   /db_xref="InterPro:IPR023299"
FT                   /db_xref="InterPro:IPR026871"
FT                   /db_xref="InterPro:IPR032630"
FT                   /db_xref="InterPro:IPR032631"
FT                   /db_xref="InterPro:IPR036412"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32660"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic
FT                   reticulum [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:12221123|PMID:12631737]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud
FT                   neck [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070867 mating
FT                   projection tip membrane [PMID:25378585]"
FT                   /experiment="EXISTENCE:direct assay:GO:0071944 cell
FT                   periphery [PMID:26928762]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000749
FT                   response to pheromone triggering conjugation with cellular
FT                   fusion [PMID:25378585]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006886
FT                   intracellular protein transport [PMID:12221123]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006897
FT                   endocytosis [PMID:12631737]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007163
FT                   establishment or maintenance of cell polarity
FT                   [PMID:15461661]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0045332
FT                   phospholipid translocation [PMID:12631737|PMID:17015438]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0090555
FT                   phosphatidylethanolamine flippase activity
FT                   [PMID:12631737|PMID:17015438]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0140345
FT                   phosphatidylcholine flippase activity [PMID:12631737]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006897
FT                   endocytosis [PMID:12631737]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045332
FT                   phospholipid translocation [PMID:17015438]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0090555
FT                   phosphatidylethanolamine flippase activity
FT                   [PMID:17015438|PMID:27432949]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0140345
FT                   phosphatidylcholine flippase activity [PMID:27432949]"
FT                   /experiment="EXISTENCE:physical interaction:GO:1990531
FT                   phospholipid-translocating ATPase complex [PMID:15090616]"
FT                   /protein_id="DAA07828.1"
FT                   /translation="MSGTFHGDGHAPMSPFEDTFQFEDNSSNEDTHIAPTHFDDGATSN
FT                   KYSRPQVSFNDETPKNKREDAEEFTFNDDTEYDNHSFQPTPKLNNGSGTFDDVELDNDS
FT                   GEPHTNYDGMKRFRMGTKRNKKGNPIMGRSKTLKWARKNIPNPFEDFTKDDIDPGAINR
FT                   AQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNILFQFHNFANVY
FT                   FLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKTHILE
FT                   GVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKRMQRKRHELRVQKTV
FT                   GTSGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDCKFAKNYWK
FT                   GVKVGDIVRIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTIRT
FT                   SKDIARTKFWIESEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKW
FT                   AMGVVMFTGGDTKIMLNSGITPTKKSRISRELNFSVVINFVLLFILCFVSGIANGVYYD
FT                   KKGRSRFSYEFGTIAGSAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAFIYGD
FT                   VLLYNAKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGRAYT
FT                   EALAGLRKRQGIDVETEGRREKAEIAKDRDTMIDELRALSGNSQFYPEEVTFVSKEFVR
FT                   DLKGASGEVQQRCCEHFMLALALCHSVLVEANPDNPKKLDLKAQSPDEAALVATARDVG
FT                   FSFVGKTKKGLIIEMQGIQKEFEILNILEFNSSRKRMSCIVKIPGLNPGDEPRALLICK
FT                   GADSIIYSRLSRQSGSNSEAILEKTALHLEQYATEGLRTLCIAQRELSWSEYEKWNEKY
FT                   DIAAASLANREDELEVVADSIERELILLGGTAIEDRLQDGVPDCIELLAEAGIKLWVLT
FT                   GDKVETAINIGFSCNLLNNEMELLVIKTTGDDVKEFGSEPSEIVDALLSKYLKEYFNLT
FT                   GSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCRVSP
FT                   SQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDYAIGQF
FT                   RYLARLVLVHGRWSYKRLAEMIPEFFYKNMIFALALFWYGIYNDFDGSYLYEYTYMMFY
FT                   NLAFTSLPVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQSIIC
FT                   FFFPYLVYHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQYRWDWFSGLFIA
FT                   LSCLVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCLLPRFTYDSFQKF
FT                   FYPTDVEIVREMWQHGHFDHYPPGYDPTDPNRPKVTKAGQHGEKIIEGIALSDNLGGSN
FT                   YSRDSVVTEEIPMTFMHGEDGSPSGYQKQETWMTSPKETQDLLQSPQFQQAQTFGRGPS
FT                   TNVRSSLDRTREQMIATNQLDNRYSVERARTSLDLPGVTNAASLIGTQQNN"
FT   gene            518216..520771
FT                   /gene="BCK2"
FT                   /gene_synonym="CTR7"
FT                   /locus_tag="YER167W"
FT   mRNA            518216..520771
FT                   /gene="BCK2"
FT                   /gene_synonym="CTR7"
FT                   /locus_tag="YER167W"
FT                   /product="Bck2p"
FT   CDS_pept        518216..520771
FT                   /codon_start=1
FT                   /gene="BCK2"
FT                   /gene_synonym="CTR7"
FT                   /locus_tag="YER167W"
FT                   /product="Bck2p"
FT                   /note="Serine/threonine-rich protein involved in PKC1
FT                   signaling pathway; protein kinase C (PKC1) signaling
FT                   pathway controls cell integrity; overproduction suppresses
FT                   pkc1 mutations"
FT                   /db_xref="GOA:P33306"
FT                   /db_xref="UniProtKB/Swiss-Prot:P33306"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:14562095]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S
FT                   transition of mitotic cell cycle [PMID:12518319]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010628 positive
FT                   regulation of gene expression [PMID:19158491]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051726
FT                   regulation of cell cycle [PMID:7891677]"
FT                   /protein_id="DAA07829.1"
FT                   /translation="MPKNSHHHRSSSVNSTKSRSTESTNKWKIPHYYRRSASGSTQASP
FT                   DRNSSTGSCSTPVLPTMNVMSSPKKVLLEDPRDNHTKAKKSSRKKSGEMVFVNYTVQDT
FT                   ANENDTDLQTQPVSVPAPKAKLKKKSSKRRMLKIFGSSKNEHIEDIVEEQPMVLQMDSE
FT                   SKPLSGTPISESGIDASSLTTKRSYNSFLKHNRLNGKTPFSGNLSFPSLNMMGNTTDLP
FT                   IDNNDFCSEKEVVPKSTHDPSLAKPPSRFTESETNSTPNLSSIPLMNTKNTRLKYNKVA
FT                   PQSSDRQKSQESGLYHSTESFNFKDQNYSNNKSSLSLNSDLSTPHFAKHSPDSPRTSRS
FT                   FNCGDSQSKVKLPEENDASIAFSKMFTRKRANTGGSTCSLASPTIAQTIQQSNIKVNKL
FT                   PTQRTTSVGSLSSMSNRYSPIRVASPGRARSATRGSSLYRLSRDLNSLPSVTDLPEMDS
FT                   TTPVNEIFLDGQPQHKSGSVKGGHRKKQESISDAQRIQHSNSYITTPSSSLVTPPYYMT
FT                   GYTLPSSASASSTPNVLETHNMNFVPSTSTVTSYRPSSNFSSFDKEYSNENDASGEFSA
FT                   FNTPMENIPALKGIPRSTLEENEEEDVLVQDIPNTAHFQRRDIMGMDTHRKDDSLDFNS
FT                   LMPHGSTTSSSIVDSVMTNSISTTTSNATGNYFQDQDKYTLVNTGLGLSDANLDHFIRS
FT                   QWKHASRSESNNNTGNRVSYSGSTPNNVDTTKTNLQVYTEFDFENPESFFHEQSKLLGE
FT                   MGHSNNNSNSAINMNEPKSADTYIGNISPDTSATVSLGDLMGSNVSNNSERNFYDGHTF
FT                   VPQYQANSSVENSNNQNAAPIANNDIDNNLQSFYFDNSN"
FT   rep_origin      520772..521030
FT                   /note="ARS521; Autonomously Replicating Sequence"
FT   gene            complement(521029..522669)
FT                   /gene="CCA1"
FT                   /gene_synonym="TNT1"
FT                   /locus_tag="YER168C"
FT   mRNA            complement(521029..522669)
FT                   /gene="CCA1"
FT                   /gene_synonym="TNT1"
FT                   /locus_tag="YER168C"
FT                   /product="tRNA adenylyltransferase"
FT   CDS_pept        complement(521029..522669)
FT                   /codon_start=1
FT                   /gene="CCA1"
FT                   /gene_synonym="TNT1"
FT                   /locus_tag="YER168C"
FT                   /product="tRNA adenylyltransferase"
FT                   /EC_number="2.7.7.72"
FT                   /note="ATP (CTP):tRNA-specific tRNA nucleotidyltransferase;
FT                   different forms targeted to the nucleus, cytosol, and
FT                   mitochondrion are generated via the use of multiple
FT                   transcriptional and translational start sites; human
FT                   homolog TRNT1 complements yeast null mutant"
FT                   /db_xref="GOA:P21269"
FT                   /db_xref="InterPro:IPR002646"
FT                   /db_xref="InterPro:IPR032828"
FT                   /db_xref="UniProtKB/Swiss-Prot:P21269"
FT                   /experiment="EXISTENCE:direct assay:GO:0001680 tRNA
FT                   3'-terminal CCA addition [PMID:1634528]"
FT                   /experiment="EXISTENCE:direct assay:GO:0004810 tRNA
FT                   adenylyltransferase activity [PMID:1634528]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005759
FT                   mitochondrial matrix [PMID:1634528]"
FT                   /experiment="EXISTENCE:direct assay:GO:0052928
FT                   CTP:3'-cytidine-tRNA cytidylyltransferase activity
FT                   [PMID:23872483]"
FT                   /experiment="EXISTENCE:direct assay:GO:0052929
FT                   ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity
FT                   [PMID:23872483]"
FT                   /protein_id="DAA07830.1"
FT                   /translation="MLRSTISLLMNSAAQKTMTNSNFVLNAPKITLTKVEQNICNLLND
FT                   YTDLYNQKYHNKPEPLTLRITGGWVRDKLLGQGSHDLDIAINVMSGEQFATGLNEYLQQ
FT                   HYAKYGAKPHNIHKIDKNPEKSKHLETATTKLFGVEVDFVNLRSEKYTELSRIPKVCFG
FT                   TPEEDALRRDATLNALFYNIHKGEVEDFTKRGLQDLKDGVLRTPLPAKQTFLDDPLRVL
FT                   RLIRFASRFNFTIDPEVMAEMGDPQINVAFNSKISRERVGVEMEKILVGPTPLLALQLI
FT                   QRAHLENVIFFWHNDSSVVKFNEENCQDMDKINHVYNDNILNSHLKSFIELYPMFLEKL
FT                   PILREKIGRSPGFQQNFILSAILSPMANLQIIGNPKKKINNLVSVTESIVKEGLKLSKN
FT                   DAAVIAKTVDSICSYEEILAKFADRSQLKKSEIGIFLRNFNGEWETAHFASLSDAFLKI
FT                   PKLETKKIELLFQNYNEFYSYIFDNNLNNCHELKPIVDGKQMAKLLQMKPGPWLGKINN
FT                   EAIRWQFDNPTGTDQELITHLKAILPKYL"
FT   gene            523369..525759
FT                   /gene="RPH1"
FT                   /gene_synonym="KDM4"
FT                   /locus_tag="YER169W"
FT   mRNA            523369..525759
FT                   /gene="RPH1"
FT                   /gene_synonym="KDM4"
FT                   /locus_tag="YER169W"
FT                   /product="Rph1p"
FT   CDS_pept        523369..525759
FT                   /codon_start=1
FT                   /gene="RPH1"
FT                   /gene_synonym="KDM4"
FT                   /locus_tag="YER169W"
FT                   /product="Rph1p"
FT                   /note="JmjC domain-containing histone demethylase; targets
FT                   tri- and dimethylated H3K36; associates with actively
FT                   transcribed regions and promotes elongation; repressor of
FT                   autophagy-related genes in nutrient-replete conditions;
FT                   damage-responsive repressor of PHR1; phosphorylated by the
FT                   Rad53p-dependent DNA damage checkpoint pathway and by a
FT                   Rim1p-mediated event during starvation; target of
FT                   stress-induced hormesis; RPH1 has a paralog, GIS1, that
FT                   arose from the whole genome duplication"
FT                   /db_xref="GOA:P39956"
FT                   /db_xref="InterPro:IPR003347"
FT                   /db_xref="InterPro:IPR003349"
FT                   /db_xref="InterPro:IPR013087"
FT                   /db_xref="InterPro:IPR036236"
FT                   /db_xref="PDB:3OPT"
FT                   /db_xref="PDB:3OPW"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39956"
FT                   /experiment="EXISTENCE:curator inference:GO:0005634 nucleus
FT                   [PMID:10523651]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000122 negative
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:10523651]"
FT                   /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding
FT                   transcription repressor activity, RNA polymerase
FT                   II-specific [PMID:10523651]"
FT                   /experiment="EXISTENCE:direct assay:GO:0016577 histone
FT                   demethylation [PMID:17369256|PMID:17371840|PMID:17525156]"
FT                   /experiment="EXISTENCE:direct assay:GO:0032454 histone
FT                   demethylase activity (H3-K9 specific) [PMID:17371840]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043565
FT                   sequence-specific DNA binding
FT                   [PMID:21296759|PMID:19111667]"
FT                   /experiment="EXISTENCE:direct assay:GO:0051864 histone
FT                   demethylase activity (H3-K36 specific)
FT                   [PMID:17369256|PMID:17371840|PMID:17525156]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000122
FT                   negative regulation of transcription by RNA polymerase II
FT                   [PMID:25660547]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0010507
FT                   negative regulation of autophagy [PMID:25660547]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0032968
FT                   positive regulation of transcription elongation from RNA
FT                   polymerase II promoter [PMID:17525156]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:25660547]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0001227
FT                   DNA-binding transcription repressor activity, RNA
FT                   polymerase II-specific [PMID:10523651]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010507 negative
FT                   regulation of autophagy [PMID:25660547]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0016577 histone
FT                   demethylation [PMID:17369256|PMID:17371840|PMID:17525156]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043565
FT                   sequence-specific DNA binding [PMID:21296759]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051864 histone
FT                   demethylase activity (H3-K36 specific)
FT                   [PMID:17369256|PMID:17371840|PMID:17525156]"
FT                   /protein_id="DAA07831.1"
FT                   /translation="MTKLIAPSEIVGGVPVFKPTYEQFEDFYAYCKAINKYGMKSGVVK
FT                   VIPPKEWKDKLDLPYSAETLQKIKIKSPIQQHISGNKGLFMVQNVEKNKTYNIIQWKDL
FT                   SKDYVPPEDPKARRNSRKGSVSKSTKLKLKNFESSFNIDDFEQFRTEYTIDLSDFQNTE
FT                   RLKFLEEYYWKTLNFTTPMYGADTPGSIFPEGLNVWNVAKLPNILDHMETKVPGVNDSY
FT                   LYAGLWKASFSWHLEDQDLYSINYIHFGAPKQWYSIPQEDRFKFYKFMQEQFPEEAKNC
FT                   PEFLRHKMFLASPKLLQENGIRCNEIVHHEGEFMITYPYGYHAGFNYGYNLAESVNFAL
FT                   EEWLPIGKKAGKCHCISDSVEIDVKKLAKSWRDNNKESKGTPPLNQLPNPAMPLLHRPT
FT                   LKEMESSSLRSTSPDVGHFSNFKSKSSGVSSPLLSRMKDYSNIVEPTLEDPTLKLKRIS
FT                   SFQEQPLNKLLKRETSQTAMLTDHEDNIVAMSLTSMANSAASSPRLPLSRLNSSNELSN
FT                   AQPLLDMTNNTLAFPRPNGPSGLNPLLYISNKNISGISHSAPHSPVNPNISLIKRVKSP
FT                   NIVTLNISRESSRSPIALNYEARQQHSQQHSFSTPSTVSNLSTSVLGPLSDTNDIKTPH
FT                   PERPNHKTANRILKKESPVETSKSNLILSKVASTRQEDSFTSRNDDLDKEQGSSPLNSK
FT                   FAPEEIVLSGKNKIYICKECQRKFSSGHHLTRHKKSVHSGEKPHSCPKCGKRFKRRDHV
FT                   LQHLNKKIPCISNETTVDAPIMNPTVQPQDGKAAINQQSTPLN"
FT   gene            525974..526651
FT                   /gene="ADK2"
FT                   /gene_synonym="AKY3"
FT                   /gene_synonym="PAK3"
FT                   /locus_tag="YER170W"
FT   mRNA            525974..526651
FT                   /gene="ADK2"
FT                   /gene_synonym="AKY3"
FT                   /gene_synonym="PAK3"
FT                   /locus_tag="YER170W"
FT                   /product="adenylate kinase ADK2"
FT   CDS_pept        525974..526651
FT                   /codon_start=1
FT                   /gene="ADK2"
FT                   /gene_synonym="AKY3"
FT                   /gene_synonym="PAK3"
FT                   /locus_tag="YER170W"
FT                   /product="adenylate kinase ADK2"
FT                   /EC_number="2.7.4.10"
FT                   /note="Mitochondrial adenylate kinase; catalyzes the
FT                   reversible synthesis of GTP and AMP from GDP and ADP; may
FT                   serve as a back-up for synthesizing GTP or ADP depending on
FT                   metabolic conditions; 3' sequence of ADK2 varies with
FT                   strain background"
FT                   /db_xref="GOA:P26364"
FT                   /db_xref="InterPro:IPR000850"
FT                   /db_xref="InterPro:IPR006259"
FT                   /db_xref="InterPro:IPR007862"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR028586"
FT                   /db_xref="InterPro:IPR033690"
FT                   /db_xref="UniProtKB/Swiss-Prot:P26364"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005743
FT                   mitochondrial inner membrane [PMID:15753074|PMID:8537371]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005759
FT                   mitochondrial matrix [PMID:8537371]"
FT                   /experiment="EXISTENCE:direct assay:GO:0009117 nucleotide
FT                   metabolic process [PMID:15753074]"
FT                   /experiment="EXISTENCE:direct assay:GO:0046899 nucleoside
FT                   triphosphate adenylate kinase activity
FT                   [PMID:15753074|PMID:8537371]"
FT                   /protein_id="DAA07832.1"
FT                   /translation="MKADAKQITHLLKPLRLLLLGAPGSGKGTQTSRLLKQIPQLSSIS
FT                   SGDILRQEIKSESTLGREATTYIAQGKLLPDDLITRLITFRLSALGWLKPSAMWLLDGF
FT                   PRTTAQASALDELLKQHDASLNLVVELDVPESTILERIENRYVHVPSGRVYNLQYNPPK
FT                   VPGLDDITGEPLTKRLDDTAEVFKKRLEEYKKTNEPLKDYYKKSGIFGTVSGETSDIIF
FT                   RNY"
FT   gene            527082..529418
FT                   /gene="RAD3"
FT                   /gene_synonym="REM1"
FT                   /locus_tag="YER171W"
FT   mRNA            527082..529418
FT                   /gene="RAD3"
FT                   /gene_synonym="REM1"
FT                   /locus_tag="YER171W"
FT                   /product="TFIIH/NER complex ATP-dependent 5'-3' DNA
FT                   helicase subunit RAD3"
FT   CDS_pept        527082..529418
FT                   /codon_start=1
FT                   /gene="RAD3"
FT                   /gene_synonym="REM1"
FT                   /locus_tag="YER171W"
FT                   /product="TFIIH/NER complex ATP-dependent 5'-3' DNA
FT                   helicase subunit RAD3"
FT                   /EC_number="3.6.4.12"
FT                   /note="5' to 3' DNA helicase; involved in nucleotide
FT                   excision repair and transcription; subunit of RNA polII
FT                   initiation factor TFIIH and of Nucleotide Excision Repair
FT                   Factor 3 (NEF3); homolog of human XPD protein; mutant has
FT                   aneuploidy tolerance; protein abundance increases in
FT                   response to DNA replication stress"
FT                   /db_xref="GOA:P06839"
FT                   /db_xref="InterPro:IPR001945"
FT                   /db_xref="InterPro:IPR002464"
FT                   /db_xref="InterPro:IPR006554"
FT                   /db_xref="InterPro:IPR006555"
FT                   /db_xref="InterPro:IPR010614"
FT                   /db_xref="InterPro:IPR010643"
FT                   /db_xref="InterPro:IPR013020"
FT                   /db_xref="InterPro:IPR014013"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="PDB:5FMF"
FT                   /db_xref="PDB:5OQJ"
FT                   /db_xref="PDB:5OQM"
FT                   /db_xref="PDB:5SVA"
FT                   /db_xref="PDB:6GYM"
FT                   /db_xref="UniProtKB/Swiss-Prot:P06839"
FT                   /experiment="EXISTENCE:direct assay:GO:0000112
FT                   nucleotide-excision repair factor 3 complex [PMID:8855246]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000439
FT                   transcription factor TFIIH core complex
FT                   [PMID:14500720|PMID:19818408]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA
FT                   binding [PMID:8132553]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005675
FT                   transcription factor TFIIH holo complex
FT                   [PMID:19818408|PMID:27381459]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006366
FT                   transcription by RNA polymerase II [PMID:19818408]"
FT                   /experiment="EXISTENCE:direct assay:GO:0033683
FT                   nucleotide-excision repair, DNA incision [PMID:8631896]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043139 5'-3' DNA
FT                   helicase activity [PMID:2827162]"
FT                   /experiment="EXISTENCE:direct assay:GO:0070816
FT                   phosphorylation of RNA polymerase II C-terminal domain
FT                   [PMID:19450536|PMID:19679665]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000019
FT                   regulation of mitotic recombination
FT                   [PMID:10713167|PMID:9799251]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0010525
FT                   regulation of transposition, RNA-mediated [PMID:10713167]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045951 positive
FT                   regulation of mitotic recombination [PMID:24189665]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006289
FT                   nucleotide-excision repair [PMID:7026973]"
FT                   /protein_id="DAA07833.1"
FT                   /translation="MKFYIDDLPVLFPYPKIYPEQYNYMCDIKKTLDVGGNSILEMPSG
FT                   TGKTVSLLSLTIAYQMHYPEHRKIIYCSRTMSEIEKALVELENLMDYRTKELGYQEDFR
FT                   GLGLTSRKNLCLHPEVSKERKGTVVDEKCRRMTNGQAKRKLEEDPEANVELCEYHENLY
FT                   NIEVEDYLPKGVFSFEKLLKYCEEKTLCPYFIVRRMISLCNIIIYSYHYLLDPKIAERV
FT                   SNEVSKDSIVIFDEAHNIDNVCIESLSLDLTTDALRRATRGANALDERISEVRKVDSQK
FT                   LQDEYEKLVQGLHSADILTDQEEPFVETPVLPQDLLTEAIPGNIRRAEHFVSFLKRLIE
FT                   YLKTRMKVLHVISETPKSFLQHLKQLTFIERKPLRFCSERLSLLVRTLEVTEVEDFTAL
FT                   KDIATFATLISTYEEGFLLIIEPYEIENAAVPNPIMRFTCLDASIAIKPVFERFSSVII
FT                   TSGTISPLDMYPRMLNFKTVLQKSYAMTLAKKSFLPMIITKGSDQVAISSRFEIRNDPS
FT                   IVRNYGSMLVEFAKITPDGMVVFFPSYLYMESIVSMWQTMGILDEVWKHKLILVETPDA
FT                   QETSLALETYRKACSNGRGAILLSVARGKVSEGIDFDHQYGRTVLMIGIPFQYTESRIL
FT                   KARLEFMRENYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGVMVLADRRFSRKRSQLP
FT                   KWIAQGLSDADLNLSTDMAISNTKQFLRTMAQPTDPKDQEGVSVWSYEDLIKHQNSRKD
FT                   QGGFIENENKEGEQDEDEDEDIEMQ"
FT   gene            complement(529530..536021)
FT                   /gene="BRR2"
FT                   /gene_synonym="PRP44"
FT                   /gene_synonym="RSS1"
FT                   /gene_synonym="SLT22"
FT                   /gene_synonym="SNU246"
FT                   /locus_tag="YER172C"
FT   mRNA            complement(529530..536021)
FT                   /gene="BRR2"
FT                   /gene_synonym="PRP44"
FT                   /gene_synonym="RSS1"
FT                   /gene_synonym="SLT22"
FT                   /gene_synonym="SNU246"
FT                   /locus_tag="YER172C"
FT                   /product="ATP-dependent RNA helicase BRR2"
FT   CDS_pept        complement(529530..536021)
FT                   /codon_start=1
FT                   /gene="BRR2"
FT                   /gene_synonym="PRP44"
FT                   /gene_synonym="RSS1"
FT                   /gene_synonym="SLT22"
FT                   /gene_synonym="SNU246"
FT                   /locus_tag="YER172C"
FT                   /product="ATP-dependent RNA helicase BRR2"
FT                   /EC_number="3.6.4.13"
FT                   /note="RNA-dependent ATPase RNA helicase (DEIH box);
FT                   required for disruption of U4/U6 base-pairing in native
FT                   snRNPs to activate the spliceosome for catalysis;
FT                   homologous to human U5-200kD"
FT                   /db_xref="GOA:P32639"
FT                   /db_xref="InterPro:IPR001650"
FT                   /db_xref="InterPro:IPR004179"
FT                   /db_xref="InterPro:IPR011545"
FT                   /db_xref="InterPro:IPR014001"
FT                   /db_xref="InterPro:IPR014756"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR035892"
FT                   /db_xref="InterPro:IPR036390"
FT                   /db_xref="InterPro:IPR041094"
FT                   /db_xref="PDB:3HIB"
FT                   /db_xref="PDB:3IM1"
FT                   /db_xref="PDB:3IM2"
FT                   /db_xref="PDB:3JCM"
FT                   /db_xref="PDB:4BGD"
FT                   /db_xref="PDB:5DCA"
FT                   /db_xref="PDB:5GAN"
FT                   /db_xref="PDB:5GAO"
FT                   /db_xref="PDB:5GAP"
FT                   /db_xref="PDB:5GM6"
FT                   /db_xref="PDB:5LJ5"
FT                   /db_xref="PDB:5LQW"
FT                   /db_xref="PDB:5M52"
FT                   /db_xref="PDB:5M5P"
FT                   /db_xref="PDB:5NRL"
FT                   /db_xref="PDB:5ZWM"
FT                   /db_xref="PDB:5ZWO"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32639"
FT                   /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase
FT                   activity [PMID:8649518]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP
FT                   [PMID:11720284]"
FT                   /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5
FT                   tri-snRNP complex
FT                   [PMID:10377396|PMID:10449419|PMID:8670905]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000388
FT                   spliceosome conformational change to release U4 (or U4atac)
FT                   and U1 (or U11) [PMID:9705931]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0003724 RNA
FT                   helicase activity [PMID:8649518|PMID:9705931]"
FT                   /protein_id="DAA07834.1"
FT                   /translation="MTEHETKDKAKKIREIYRYDEMSNKVLKVDKRFMNTSQNPQRDAE
FT                   ISQPKSMSGRISAKDMGQGLCNNINKGLKENDVAVEKTGKSASLKKIQQHNTILNSSSD
FT                   FRLHYYPKDPSNVETYEQILQWVTEVLGNDIPHDLIIGTADIFIRQLKENEENEDGNIE
FT                   ERKEKIQHELGINIDSLKFNELVKLMKNITDYETHPDNSNKQAVAILADDEKSDEEEVT
FT                   EMSNNANVLGGEINDNEDDDEEYDYNDVEVNSKKKNKRALPNIENDIIKLSDSKTSNIE
FT                   SVPIYSIDEFFLQRKLRSELGYKDTSVIQDLSEKILNDIETLEHNPVALEQKLVDLLKF
FT                   ENISLAEFILKNRSTIFWGIRLAKSTENEIPNLIEKMVAKGLNDLVEQYKFRETTHSKR
FT                   ELDSGDDQPQSSEAKRTKFSNPAIPPVIDLEKIKFDESSKLMTVTKVSLPEGSFKRVKP
FT                   QYDEIHIPAPSKPVIDYELKEITSLPDWCQEAFPSSETTSLNPIQSKVFHAAFEGDSNM
FT                   LICAPTGSGKTNIALLTVLKALSHHYNPKTKKLNLSAFKIVYIAPLKALVQEQVREFQR
FT                   RLAFLGIKVAELTGDSRLSRKQIDETQVLVSTPEKWDITTRNSNNLAIVELVRLLIIDE
FT                   IHLLHDDRGPVLESIVARTFWASKYGQEYPRIIGLSATLPNYEDVGRFLRVPKEGLFYF
FT                   DSSFRPCPLSQQFCGIKERNSLKKLKAMNDACYEKVLESINEGNQIIVFVHSRKETSRT
FT                   ATWLKNKFAEENITHKLTKNDAGSKQILKTEAANVLDPSLRKLIESGIGTHHAGLTRSD
FT                   RSLSEDLFADGLLQVLVCTATLAWGVNLPAHTVIIKGTDVYSPEKGSWEQLSPQDVLQM
FT                   LGRAGRPRYDTFGEGIIITDQSNVQYYLSVLNQQLPIESQFVSKLVDNLNAEVVAGNIK
FT                   CRNDAVNWLAYTYLYVRMLASPMLYKVPDISSDGQLKKFRESLVHSALCILKEQELVLY
FT                   DAENDVIEATDLGNIASSFYINHASMDVYNRELDEHTTQIDLFRIFSMSEEFKYVSVRY
FT                   EEKRELKQLLEKAPIPIREDIDDPLAKVNVLLQSYFSQLKFEGFALNSDIVFIHQNAGR
FT                   LLRAMFEICLKRGWGHPTRMLLNLCKSATTKMWPTNCPLRQFKTCPVEVIKRLEASTVP
FT                   WGDYLQLETPAEVGRAIRSEKYGKQVYDLLKRFPKMSVTCNAQPITRSVMRFNIEIIAD
FT                   WIWDMNVHGSLEPFLLMLEDTDGDSILYYDVLFITPDIVGHEFTLSFTYELKQHNQNNL
FT                   PPNFFLTLISENWWHSEFEIPVSFNGFKLPKKFPPPTPLLENISISTSELGNDDFSEVF
FT                   EFKTFNKIQSQVFESLYNSNDSVFVGSGKGTGKTAMAELALLNHWRQNKGRAVYINPSG
FT                   EKIDFLLSDWNKRFSHLAGGKIINKLGNDPSLNLKLLAKSHVLLATPVQFELLSRRWRQ
FT                   RKNIQSLELMIYDDAHEISQGVYGAVYETLISRMIFIATQLEKKIRFVCLSNCLANARD
FT                   FGEWAGMTKSNIYNFSPSERIEPLEINIQSFKDVEHISFNFSMLQMAFEASAAAAGNRN
FT                   SSSVFLPSRKDCMEVASAFMKFSKAIEWDMLNVEEEQIVPYIEKLTDGHLRAPLKHGVG
FT                   ILYKGMASNDERIVKRLYEYGAVSVLLISKDCSAFACKTDEVIILGTNLYDGAEHKYMP
FT                   YTINELLEMVGLASGNDSMAGKVLILTSHNMKAYYKKFLIEPLPTESYLQYIIHDTLNN
FT                   EIANSIIQSKQDCVDWFTYSYFYRRIHVNPSYYGVRDTSPHGISVFLSNLVETCLNDLV
FT                   ESSFIEIDDTEAEVTAEVNGGDDEATEIISTLSNGLIASHYGVSFFTIQSFVSSLSNTS
FT                   TLKNMLYVLSTAVEFESVPLRKGDRALLVKLSKRLPLRFPEHTSSGSVSFKVFLLLQAY
FT                   FSRLELPVDFQNDLKDILEKVVPLINVVVDILSANGYLNATTAMDLAQMLIQGVWDVDN
FT                   PLRQIPHFNNKILEKCKEINVETVYDIMALEDEERDEILTLTDSQLAQVAAFVNNYPNV
FT                   ELTYSLNNSDSLISGVKQKITIQLTRDVEPENLQVTSEKYPFDKLESWWLVLGEVSKKE
FT                   LYAIKKVTLNKETQQYELEFDTPTSGKHNLTIWCVCDSYLDADKELSFEINVK"
FT   gene            536300..538279
FT                   /gene="RAD24"
FT                   /locus_tag="YER173W"
FT   mRNA            536300..538279
FT                   /gene="RAD24"
FT                   /locus_tag="YER173W"
FT                   /product="Rad24p"
FT   CDS_pept        536300..538279
FT                   /codon_start=1
FT                   /gene="RAD24"
FT                   /locus_tag="YER173W"
FT                   /product="Rad24p"
FT                   /note="Checkpoint protein; involved in the activation of
FT                   the DNA damage and meiotic pachytene checkpoints; subunit
FT                   of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA;
FT                   homolog of human and S. pombe Rad17 protein"
FT                   /db_xref="GOA:P32641"
FT                   /db_xref="InterPro:IPR004582"
FT                   /db_xref="InterPro:IPR018324"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32641"
FT                   /experiment="EXISTENCE:direct assay:GO:0003689 DNA clamp
FT                   loader activity [PMID:12604797]"
FT                   /experiment="EXISTENCE:direct assay:GO:0031389 Rad17
FT                   RFC-like complex [PMID:12604797|PMID:10660302]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA
FT                   damage checkpoint [PMID:9564050]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006289
FT                   nucleotide-excision repair [PMID:11267834]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007131
FT                   reciprocal meiotic recombination [PMID:10511543]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0031389
FT                   Rad17 RFC-like complex [PMID:10660302]"
FT                   /protein_id="DAA07835.1"
FT                   /translation="MDSTNLNKRPLLQYSLSSLGSQITKWSSSRPTSPVRKARSTENDF
FT                   LSKQDTSSILPSINDDGGEQWYEKFKPNCLEQVAIHKRKLKDVQEALDAMFLPNAKHRI
FT                   LLLSGPSGCSKSTVIKELSKILVPKYRQNSNGTSFRSTPNEHKVTEFRGDCIVNDLPQM
FT                   ESFSEFLKGARYLVMSNLSLILIEDLPNVFHIDTRRRFQQLILQWLYSSEPLLPPLVIC
FT                   ITECEIPENDNNYRKFGIDYTFSAETIMNKEILMHPRLKRIKFNPINSTLLKKHLKFIC
FT                   VQNMKMLKEKNKWNKRQEVIDYIAQETGDIRSAITTLQFWATSSGSLPISTRESTISYF
FT                   HAIGKVIHGSHSTNNDNEMINNLFENSNNLLSKEDFKLGILENYNTFNKGEFSISDASS
FT                   IVDCLSECDNMNGLPESNEYGLREVRKTFRNISKQGHNHGTVYFPREWKVRKLQNSFKV
FT                   QAEDWLNVSLYKYNAVHSFRNITLEFGYYAPLIRKCQSYKKKYILYYLKNLPSGSSGPK
FT                   QTMDKFSDIMKVENGIDVVDRIGGPIEALSVEDGLAPLMDNDSNNCDHLEDQKKERDRR
FT                   LRMLIDQYERNVMMANDDLEDEETSFNDDPIVDSDSDNSNNIGNETFGRSDEDESLCEI
FT                   LSQRQPRKAPVISESLSDSDLEIL"
FT   gene            complement(538434..539168)
FT                   /gene="GRX4"
FT                   /locus_tag="YER174C"
FT   mRNA            complement(538434..539168)
FT                   /gene="GRX4"
FT                   /locus_tag="YER174C"
FT                   /product="monothiol glutaredoxin GRX4"
FT   CDS_pept        complement(538434..539168)
FT                   /codon_start=1
FT                   /gene="GRX4"
FT                   /locus_tag="YER174C"
FT                   /product="monothiol glutaredoxin GRX4"
FT                   /note="Glutathione-dependent oxidoreductase; hydroperoxide
FT                   and superoxide-radical responsive; monothiol glutaredoxin
FT                   subfamily member along with Grx3p and Grx5p; protects cells
FT                   from oxidative damage; with Grx3p, binds to Aft1p in
FT                   iron-replete conditions, promoting its dissociation from
FT                   promoters; mutant has increased aneuploidy tolerance;
FT                   transcription regulated by Yap5p; GRX4 has a paralog, GRX3,
FT                   that arose from the whole genome duplication"
FT                   /db_xref="GOA:P32642"
FT                   /db_xref="InterPro:IPR002109"
FT                   /db_xref="InterPro:IPR004480"
FT                   /db_xref="InterPro:IPR013766"
FT                   /db_xref="InterPro:IPR033658"
FT                   /db_xref="InterPro:IPR036249"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32642"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:14519092]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0006879
FT                   cellular iron ion homeostasis [PMID:17074835]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0015036
FT                   disulfide oxidoreductase activity
FT                   [PMID:10567543|PMID:27085841]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin
FT                   cytoskeleton organization [PMID:20889785]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0031065 positive
FT                   regulation of histone deacetylation [PMID:27085841]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular
FT                   response to oxidative stress [PMID:10567543|PMID:17074835]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:2000678 negative
FT                   regulation of transcription regulatory region DNA binding
FT                   [PMID:23045394]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0001102 RNA
FT                   polymerase II activating transcription factor binding
FT                   [PMID:23045394]"
FT                   /experiment="EXISTENCE:physical interaction:GO:0006879
FT                   cellular iron ion homeostasis [PMID:17074835]"
FT                   /protein_id="DAA07836.1"
FT                   /translation="MTVVEIKSQDQFTQLTTTNAANKLIVLYFKAQWADPCKTMSQVLE
FT                   AVSEKVRQEDVRFLSIDADEHPEISDLFEIAAVPYFVFIQNGTIVKEISAADPKEFVKS
FT                   LEILSNASASLANNAKGPKSTSDEESSGSSDDEEDETEEEINARLVKLVQAAPVMLFMK
FT                   GSPSEPKCGFSRQLVGILREHQIRFGFFDILRDENVRQSLKKFSDWPTFPQLYINGEFQ
FT                   GGLDIIKESIEEDPEYFQHALQ"
FT   gene            complement(539464..540363)
FT                   /gene="TMT1"
FT                   /gene_synonym="TAM1"
FT                   /locus_tag="YER175C"
FT   mRNA            complement(539464..540363)
FT                   /gene="TMT1"
FT                   /gene_synonym="TAM1"
FT                   /locus_tag="YER175C"
FT                   /product="trans-aconitate 3-methyltransferase"
FT   CDS_pept        complement(539464..540363)
FT                   /codon_start=1
FT                   /gene="TMT1"
FT                   /gene_synonym="TAM1"
FT                   /locus_tag="YER175C"
FT                   /product="trans-aconitate 3-methyltransferase"
FT                   /EC_number="2.1.1.145"
FT                   /note="Trans-aconitate methyltransferase; cytosolic enzyme
FT                   that catalyzes the methyl esterification of
FT                   3-isopropylmalate, an intermediate of the leucine
FT                   biosynthetic pathway, and trans-aconitate, which inhibits
FT                   the citric acid cycle"
FT                   /db_xref="GOA:P32643"
FT                   /db_xref="InterPro:IPR025714"
FT                   /db_xref="InterPro:IPR029063"
FT                   /db_xref="PDB:3G5T"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32643"
FT                   /experiment="EXISTENCE:direct assay:GO:0005829 cytosol
FT                   [PMID:11695919]"
FT                   /experiment="EXISTENCE:direct assay:GO:0046547
FT                   trans-aconitate 3-methyltransferase activity
FT                   [PMID:11695919]"
FT                   /protein_id="DAA07837.1"
FT                   /translation="MSTFSASDFNSERYSSSRPSYPSDFYKMIDEYHDGERKLLVDVGC
FT                   GPGTATLQMAQELKPFEQIIGSDLSATMIKTAEVIKEGSPDTYKNVSFKISSSDDFKFL
FT                   GADSVDKQKIDMITAVECAHWFDFEKFQRSAYANLRKDGTIAIWGYADPIFPDYPEFDD
FT                   LMIEVPYGKQGLGPYWEQPGRSRLRNMLKDSHLDPELFHDIQVSYFCAEDVRDKVKLHQ
FT                   HTKKPLLIRKQVTLVEFADYVRTWSAYHQWKQDPKNKDKEDVADWFIKESLRRRPELST
FT                   NTKIEVVWNTFYKLGKRV"
FT   gene            540650..540814
FT                   /locus_tag="YER175W-A"
FT   mRNA            540650..540814
FT                   /locus_tag="YER175W-A"
FT                   /product="hypothetical protein"
FT   CDS_pept        540650..540814
FT                   /codon_start=1
FT                   /locus_tag="YER175W-A"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; identified by gene-trapping,
FT                   microarray-based expression analysis, and genome-wide
FT                   homology searching"
FT                   /db_xref="GOA:Q8TGU4"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q8TGU4"
FT                   /protein_id="DAA07838.1"
FT                   /translation="MRLHKTFICFSQNKRGCRNILQENSRMIFENKILIMILRQGIFFN
FT                   ISVSTKISF"
FT   gene            541690..545055
FT                   /gene="ECM32"
FT                   /gene_synonym="HEL1"
FT                   /gene_synonym="MTT1"
FT                   /locus_tag="YER176W"
FT   mRNA            541690..545055
FT                   /gene="ECM32"
FT                   /gene_synonym="HEL1"
FT                   /gene_synonym="MTT1"
FT                   /locus_tag="YER176W"
FT                   /product="RNA helicase"
FT   CDS_pept        541690..545055
FT                   /codon_start=1
FT                   /gene="ECM32"
FT                   /gene_synonym="HEL1"
FT                   /gene_synonym="MTT1"
FT                   /locus_tag="YER176W"
FT                   /product="RNA helicase"
FT                   /EC_number="3.6.4.13"
FT                   /note="DNA dependent ATPase/DNA helicase; helicase
FT                   belonging to the Dna2p- and Nam7p-like family of helicases
FT                   that is involved in modulating translation termination;
FT                   interacts with the translation termination factors,
FT                   localized to polysomes"
FT                   /db_xref="GOA:P32644"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR041677"
FT                   /db_xref="InterPro:IPR041679"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32644"
FT                   /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase
FT                   activity [PMID:9434351]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding
FT                   [PMID:23222640]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005844 polysome
FT                   [PMID:10836794]"
FT                   /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
FT                   stress granule [PMID:23222640|PMID:26777405]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0006449
FT                   regulation of translational termination [PMID:10836794]"
FT                   /protein_id="DAA07839.1"
FT                   /translation="MDFQCRTCSQAYDAEQMMKHLSSTRHKTVFDTSNDEDICCEECQD
FT                   KNIHQLQIIRFGGEDMVLLCNSCFRKEYSETERPSTSYSLQNGSILKFWEKYVKVRECC
FT                   CDECGEESNLNANRNGEVLCDKCLPKSNRAKDFVSEKSGRFLYIYLGLNETQNSTRKPR
FT                   KKGGRRVGRGKKGRKGAKIKKEKKETFEAKISRIAYEVKKENSTIQSSSSSNLRNFKGF
FT                   KAVESDPVVAAKVSKSETSRSNPGPSNRNKGKGNKANHKKNSGNGIGKEKERKTNIRNN
FT                   VRNSQPIPEDRKNTNSHVTTNSGGKGKNESVDKHQLPQPKALNGNGSGSTNTTGLKKGK
FT                   KDHAGQKTKGNDKTGNKNPREAKLNSAGRKNALGKKSNNQPNKGTSRWTIGSDTESSRE
FT                   PSISPNENTTSITKSRNRNKKASKPTLNEKSKTTTMPKKLETKNQEKNNGKTKDGKLIY
FT                   EEGEPLTRYNTFKSTLSYPDLNTYLNDYSFALFLEQKLENEFVQNFNILWPRNEKDTAF
FT                   IINVEKNNNSELEKLLPANLLALGRPAFNERQPFFFCTQDEQKVWYIFIKELSIQRGKY
FT                   VLLVELFSWNNLSLPTKNGSSQFKLLPTSAQTSRILFAMTRITNPKFIDLLLGQKPIKE
FT                   IYFDNRLKFSSDKLNRSQKTAVEHVLNNSITILQGPPGTGKTSTIEEIIIQVIERFHAF
FT                   PILCVAASNIAIDNIAEKIMENRPQIKILRILSKKKEQQYSDDHPLGEICLHNIVYKNL
FT                   SPDMQVVANKTRRGEMISKSEDTKFYKEKNRVTNKVVSQSQIIFTTNIAAGGRELKVIK
FT                   ECPVVIMDEATQSSEASTLVPLSLPGIRNFVFVGDEKQLSSFSNIPQLETSLFERVLSN
FT                   GTYKNPLMLDTQYRMHPKISEFPIKKIYNGELKDGVTDEQKAWPGVQHPLFFYQCDLGP
FT                   ESRVRSTQRDIVGFTYENKHECVEIVKIIQILMLDKKVPLEEIGVITPYSAQRDLLSDI
FT                   LTKNVVINPKQISMQQEYDEIELFNAAGSQGTAGSLQNNVINIINGLHVATVDSFQGHE
FT                   KSFIIFSCVRNNTENKIGFLRDKRRLNVALTRAKHGLIVVGNKNVLRKGDPLWKDYITY
FT                   LEEQEVIFTDLTAY"
FT   gene            545611..546414
FT                   /gene="BMH1"
FT                   /gene_synonym="APR6"
FT                   /locus_tag="YER177W"
FT   mRNA            545611..546414
FT                   /gene="BMH1"
FT                   /gene_synonym="APR6"
FT                   /locus_tag="YER177W"
FT                   /product="14-3-3 family protein BMH1"
FT   CDS_pept        545611..546414
FT                   /codon_start=1
FT                   /gene="BMH1"
FT                   /gene_synonym="APR6"
FT                   /locus_tag="YER177W"
FT                   /product="14-3-3 family protein BMH1"
FT                   /note="14-3-3 protein, major isoform; controls proteome at
FT                   post-transcriptional level, binds proteins and DNA,
FT                   involved in regulation of exocytosis, vesicle transport,
FT                   Ras/MAPK and rapamycin-sensitive signaling, aggresome
FT                   formation, spindle position checkpoint; protein increases
FT                   in abundance and relative distribution to the nucleus
FT                   increases upon DNA replication stress; antiapoptotic gene
FT                   similar to human 14-3-3; BMH1 has a paralog, BMH2, that
FT                   arose from whole genome duplication"
FT                   /db_xref="GOA:P29311"
FT                   /db_xref="InterPro:IPR000308"
FT                   /db_xref="InterPro:IPR023409"
FT                   /db_xref="InterPro:IPR023410"
FT                   /db_xref="InterPro:IPR036815"
FT                   /db_xref="PDB:5N6N"
FT                   /db_xref="UniProtKB/Swiss-Prot:P29311"
FT                   /experiment="EXISTENCE:direct assay:GO:0001102 RNA
FT                   polymerase II activating transcription factor binding
FT                   [PMID:24142105]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003688 DNA
FT                   replication origin binding [PMID:12167636]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:12167636|PMID:25409301|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm
FT                   [PMID:25409301|PMID:22842922]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:16622836]"
FT                   /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic
FT                   stress granule [PMID:26777405]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0001402
FT                   signal transduction involved in filamentous growth
FT                   [PMID:9215628]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007124
FT                   pseudohyphal growth [PMID:9215628]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007265 Ras
FT                   protein signal transduction [PMID:9215628]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0030437
FT                   ascospore formation [PMID:9215628]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0031578
FT                   mitotic spindle orientation checkpoint [PMID:24850890]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0034221
FT                   fungal-type cell wall chitin biosynthetic process
FT                   [PMID:17559233]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0070873
FT                   regulation of glycogen metabolic process [PMID:9215628]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA
FT                   damage checkpoint [PMID:14704161]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:24142105]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0043066 negative
FT                   regulation of apoptotic process [PMID:22785534]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0050815
FT                   phosphoserine residue binding [PMID:9822578]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0070842
FT                   aggresome assembly [PMID:23843611]"
FT                   /experiment="EXISTENCE:physical interaction:GO:1904667
FT                   negative regulation of ubiquitin protein ligase activity
FT                   [PMID:17030612]"
FT                   /protein_id="DAA07840.1"
FT                   /translation="MSTSREDSVYLAKLAEQAERYEEMVENMKTVASSGQELSVEERNL
FT                   LSVAYKNVIGARRASWRIVSSIEQKEESKEKSEHQVELICSYRSKIETELTKISDDILS
FT                   VLDSHLIPSATTGESKVFYYKMKGDYHRYLAEFSSGDAREKATNASLEAYKTASEIATT
FT                   ELPPTHPIRLGLALNFSVFYYEIQNSPDKACHLAKQAFDDAIAELDTLSEESYKDSTLI
FT                   MQLLRDNLTLWTSDMSESGQAEDQQQQQQHQQQQPPAAAEGEAPK"
FT   gene            546817..548079
FT                   /gene="PDA1"
FT                   /locus_tag="YER178W"
FT   mRNA            546817..548079
FT                   /gene="PDA1"
FT                   /locus_tag="YER178W"
FT                   /product="pyruvate dehydrogenase (acetyl-transferring)
FT                   subunit E1 alpha"
FT   CDS_pept        546817..548079
FT                   /codon_start=1
FT                   /gene="PDA1"
FT                   /locus_tag="YER178W"
FT                   /product="pyruvate dehydrogenase (acetyl-transferring)
FT                   subunit E1 alpha"
FT                   /EC_number="1.2.4.1"
FT                   /note="E1 alpha subunit of the pyruvate dehydrogenase (PDH)
FT                   complex; catalyzes the direct oxidative decarboxylation of
FT                   pyruvate to acetyl-CoA; phosphorylated; regulated by
FT                   glucose; PDH complex is concentrated in spots within the
FT                   mitochondrial matrix, often near the ERMES complex and near
FT                   peroxisomes"
FT                   /db_xref="GOA:P16387"
FT                   /db_xref="InterPro:IPR001017"
FT                   /db_xref="InterPro:IPR017597"
FT                   /db_xref="InterPro:IPR029061"
FT                   /db_xref="UniProtKB/Swiss-Prot:P16387"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion
FT                   [PMID:7589446|PMID:14576278|PMID:16823961|PMID:24769239]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005967
FT                   mitochondrial pyruvate dehydrogenase complex
FT                   [PMID:2007123]"
FT                   /experiment="EXISTENCE:direct assay:GO:0006086 acetyl-CoA
FT                   biosynthetic process from pyruvate [PMID:7947791]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042645
FT                   mitochondrial nucleoid [PMID:15692048]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0004739 pyruvate
FT                   dehydrogenase (acetyl-transferring) activity
FT                   [PMID:11589696]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007124
FT                   pseudohyphal growth [PMID:24603354]"
FT                   /protein_id="DAA07841.1"
FT                   /translation="MLAASFKRQPSQLVRGLGAVLRTPTRIGHVRTMATLKTTDKKAPE
FT                   DIEGSDTVQIELPESSFESYMLEPPDLSYETSKATLLQMYKDMVIIRRMEMACDALYKA
FT                   KKIRGFCHLSVGQEAIAVGIENAITKLDSIITSYRCHGFTFMRGASVKAVLAELMGRRA
FT                   GVSYGKGGSMHLYAPGFYGGNGIVGAQVPLGAGLAFAHQYKNEDACSFTLYGDGASNQG
FT                   QVFESFNMAKLWNLPVVFCCENNKYGMGTAASRSSAMTEYFKRGQYIPGLKVNGMDILA
FT                   VYQASKFAKDWCLSGKGPLVLEYETYRYGGHSMSDPGTTYRTRDEIQHMRSKNDPIAGL
FT                   KMHLIDLGIATEAEVKAYDKSARKYVDEQVELADAAPPPEAKLSILFEDVYVKGTETPT
FT                   LRGRIPEDTWDFKKQGFASRD"
FT   gene            548421..549517
FT                   /gene="DMC1"
FT                   /gene_synonym="ISC2"
FT                   /locus_tag="YER179W"
FT   mRNA            join(548421..548552,548645..549517)
FT                   /gene="DMC1"
FT                   /gene_synonym="ISC2"
FT                   /locus_tag="YER179W"
FT                   /product="recombinase DMC1"
FT   CDS_pept        join(548421..548552,548645..549517)
FT                   /codon_start=1
FT                   /gene="DMC1"
FT                   /gene_synonym="ISC2"
FT                   /locus_tag="YER179W"
FT                   /product="recombinase DMC1"
FT                   /note="Meiosis-specific recombinase required for
FT                   double-strand break repair; also required for pairing
FT                   between homologous chromosomes and for the normal
FT                   morphogenesis of synaptonemal complex; binds ssDNA and
FT                   dsDNA, forms helical filaments; potent inhibitor of the
FT                   ATPase activity of Srs2p helicase, blocking its ssDNA
FT                   translocating motor activity and inhibiting its
FT                   antirecombinase activity; stimulated by Rdh54p; homolog of
FT                   Rad51p and the bacterial RecA protein"
FT                   /db_xref="GOA:P25453"
FT                   /db_xref="InterPro:IPR003593"
FT                   /db_xref="InterPro:IPR010995"
FT                   /db_xref="InterPro:IPR011940"
FT                   /db_xref="InterPro:IPR013632"
FT                   /db_xref="InterPro:IPR016467"
FT                   /db_xref="InterPro:IPR020587"
FT                   /db_xref="InterPro:IPR020588"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="InterPro:IPR033925"
FT                   /db_xref="UniProtKB/Swiss-Prot:P25453"
FT                   /experiment="EXISTENCE:direct assay:GO:0000150 recombinase
FT                   activity [PMID:23769192]"
FT                   /experiment="EXISTENCE:direct assay:GO:0000794 condensed
FT                   nuclear chromosome [PMID:1581960]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003690
FT                   double-stranded DNA binding [PMID:11551925]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003697
FT                   single-stranded DNA binding [PMID:11551925]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:7528104|PMID:24390141]"
FT                   /experiment="EXISTENCE:direct assay:GO:0042030 ATPase
FT                   inhibitor activity [PMID:30301803]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0007130
FT                   synaptonemal complex assembly [PMID:24367271]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0000709 meiotic
FT                   joint molecule formation [PMID:22955832|PMID:9323140]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0007131
FT                   reciprocal meiotic recombination
FT                   [PMID:1581960|PMID:16581767]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic
FT                   cell cycle [PMID:1581960]"
FT                   /protein_id="DAA07842.1"
FT                   /translation="MSVTGTEIDSDTAKNILSVDELQNYGINASDLQKLKSGGIYTVNT
FT                   VLSTTRRHLCKIKGLSEVKVEKIKEAAGKIIQVGFIPATVQLDIRQRVYSLSTGSKQLD
FT                   SILGGGIMTMSITEVFGEFRCGKTQMSHTLCVTTQLPREMGGGEGKVAYIDTEGTFRPE
FT                   RIKQIAEGYELDPESCLANVSYARALNSEHQMELVEQLGEELSSGDYRLIVVDSIMANF
FT                   RVDYCGRGELSERQQKLNQHLFKLNRLAEEFNVAVFLTNQVQSDPGASALFASADGRKP
FT                   IGGHVLAHASATRILLRKGRGDERVAKLQDSPDMPEKECVYVIGEKGITDSSD"
FT   rep_origin      549566..549814
FT                   /note="ARS522; Autonomously Replicating Sequence; active
FT                   origin of replication near the right end of Chromosome V
FT                   that is activated late in S phase, late activation appears
FT                   to result from telomeric proximity"
FT   gene            complement(549724..550527)
FT                   /gene="ISC10"
FT                   /locus_tag="YER180C"
FT   mRNA            complement(549724..550527)
FT                   /gene="ISC10"
FT                   /locus_tag="YER180C"
FT                   /product="Isc10p"
FT   CDS_pept        complement(549724..550527)
FT                   /codon_start=1
FT                   /gene="ISC10"
FT                   /locus_tag="YER180C"
FT                   /product="Isc10p"
FT                   /note="Protein required for sporulation; transcript is
FT                   induced 7.5 hours after induction of meiosis, expected to
FT                   play significant role in the formation of reproductive
FT                   cells"
FT                   /db_xref="GOA:P32645"
FT                   /db_xref="UniProtKB/Swiss-Prot:P32645"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0030437
FT                   ascospore formation [PMID:8455558]"
FT                   /protein_id="DAA07843.1"
FT                   /translation="MDVDERLHQDENQTHPFSQKKSSSFLIKEKAATKSKDLEHIRLRD
FT                   LNFNHRKKLDDKKLAKQIPVKANFKKPNEIEARANLNSNELTDINLDYIPDSPSIEKIS
FT                   GPEDSIVVTPRNIIHLQSDSDIILEECEHNYDCSPFYRLFNYENRIEPDDYEAIINAII
FT                   TDEIAGTYPVFERELEYQELKSLVRKRDYIMYYFLSRDYRGFFQLKEERTLFYRYPSIA
FT                   YTSPLRYLDNGSETEQFTGDDDEELQSFDFENTSSVRTLDSNIWR"
FT   gene            complement(550865..551122)
FT                   /gene="SLO1"
FT                   /locus_tag="YER180C-A"
FT   mRNA            complement(550865..551122)
FT                   /gene="SLO1"
FT                   /locus_tag="YER180C-A"
FT                   /product="Slo1p"
FT   CDS_pept        complement(550865..551122)
FT                   /codon_start=1
FT                   /gene="SLO1"
FT                   /locus_tag="YER180C-A"
FT                   /product="Slo1p"
FT                   /note="Protein interacting with Arl3p; Arl3p is a GTPase of
FT                   the Ras superfamily involved in vesicle-tethering at the
FT                   Golgi; putative ortholog of human SCOCO"
FT                   /db_xref="EnsemblGenomes-Gn:YER180C-A"
FT                   /db_xref="EnsemblGenomes-Tr:YER180C-A"
FT                   /db_xref="GOA:Q3E784"
FT                   /db_xref="InterPro:IPR019357"
FT                   /db_xref="UniProtKB/Swiss-Prot:Q3E784"
FT                   /experiment="EXISTENCE:physical interaction:GO:0006886
FT                   intracellular protein transport [PMID:12620189]"
FT                   /protein_id="DAA07844.1"
FT                   /translation="MSAENISTGSPTGKQPSSEVNLGEREAGTKNERMMRQTKLLKDTL
FT                   DLLWNKTLEQQEVCEQLKQENDYLEDYIGNLMRSSNVLEK"
FT   gene            complement(551285..551358)
FT                   /locus_tag="tI(AAU)E2"
FT   tRNA            complement(551285..551358)
FT                   /locus_tag="tI(AAU)E2"
FT                   /product="tRNA-Ile"
FT                   /note="tI(AAU)E2; Isoleucine tRNA (tRNA-Ile), predicted by
FT                   tRNAscan-SE analysis"
FT                   /experiment="EXISTENCE:curator inference:GO:0005829 cytosol
FT                   [PMID:9023104]"
FT                   /experiment="EXISTENCE:curator inference:GO:0006414
FT                   translational elongation [PMID:9023104]"
FT   repeat_region   551442..551773
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            complement(551473..551796)
FT                   /locus_tag="YER181C"
FT   mRNA            complement(551473..551796)
FT                   /locus_tag="YER181C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(551473..551796)
FT                   /codon_start=1
FT                   /locus_tag="YER181C"
FT                   /product="hypothetical protein"
FT                   /note="Mitochondrial hypothetical protein; conserved among
FT                   S. cerevisiae strains; extensively overlaps a Ty1 LTR;
FT                   YER181C is not an essential gene"
FT                   /db_xref="GOA:P40097"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40097"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /protein_id="DAA80290.1"
FT                   /translation="MLILLRLSEVCVNFVIIIGIPLLIEASILCIQNILELLLKGIGIL
FT                   KFNRYLHTIILRLFFLSFYMLHFPITLSILAFQLPLNLLTLSQASFHLPRSHMILYQQQ
FT                   ECY"
FT   repeat_region   complement(552040..552267)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty1 LTR"
FT   gene            552525..553259
FT                   /gene="FMP10"
FT                   /locus_tag="YER182W"
FT   mRNA            552525..553259
FT                   /gene="FMP10"
FT                   /locus_tag="YER182W"
FT                   /product="Fmp10p"
FT   CDS_pept        552525..553259
FT                   /codon_start=1
FT                   /gene="FMP10"
FT                   /locus_tag="YER182W"
FT                   /product="Fmp10p"
FT                   /note="hypothetical protein; the authentic, non-tagged
FT                   protein is detected in highly purified mitochondria in
FT                   high-throughput studies"
FT                   /db_xref="GOA:P40098"
FT                   /db_xref="InterPro:IPR029069"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40098"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion
FT                   [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24390141|P
FT                   MID:24769239]"
FT                   /protein_id="DAA07845.1"
FT                   /translation="MFKRIAIAQIRTYTNGVVFKTASKPKRRWIPWTIFGGSFLGGWYL
FT                   TQHMTFTDLLAYWRYDALPKNADEVVKYHADLNRRLNGLPIVKQLENAGFVQVIANEEE
FT                   NLLVSRALNTPGGVAIPPRVYYNPSRRETVGLYHLGMKLTGYPFLIHGGILATVIEDLM
FT                   KEAIRLEKGTKNINQETKNLSISYKFPTLANQFVVVRTTDLQQYGNKTKLKAELMDQSG
FT                   NRTLVKANATFSSEQGNPKEEK"
FT   gene            complement(553334..553969)
FT                   /gene="FAU1"
FT                   /locus_tag="YER183C"
FT   mRNA            complement(553334..553969)
FT                   /gene="FAU1"
FT                   /locus_tag="YER183C"
FT                   /product="5-formyltetrahydrofolate cyclo-ligase"
FT   CDS_pept        complement(553334..553969)
FT                   /codon_start=1
FT                   /gene="FAU1"
FT                   /locus_tag="YER183C"
FT                   /product="5-formyltetrahydrofolate cyclo-ligase"
FT                   /EC_number="6.3.3.2"
FT                   /note="5,10-methenyltetrahydrofolate synthetase; involved
FT                   in folic acid biosynthesis"
FT                   /db_xref="GOA:P40099"
FT                   /db_xref="InterPro:IPR002698"
FT                   /db_xref="InterPro:IPR024185"
FT                   /db_xref="InterPro:IPR037171"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40099"
FT                   /experiment="EXISTENCE:direct assay:GO:0005739
FT                   mitochondrion [PMID:14576278|PMID:16823961]"
FT                   /experiment="EXISTENCE:direct assay:GO:0009396 folic
FT                   acid-containing compound biosynthetic process
FT                   [PMID:11923304]"
FT                   /experiment="EXISTENCE:direct assay:GO:0030272
FT                   5-formyltetrahydrofolate cyclo-ligase activity
FT                   [PMID:11923304]"
FT                   /protein_id="DAA07846.1"
FT                   /translation="MATKQLLRRQIKRVINALDYDIIAAESHTISQAVRSLIASANSRR
FT                   VACYMSMDKGEVTTGEIIKNLFQDGQEVFLPRCTHTSESKHFKLREDHHPHLIFHRMSS
FT                   LKMVRDLKPQGPYQLKEPEPHIEESDILDVVLVPGVAFDIKTGARMGHGAGYYDDFFQR
FT                   YKILHEGQKPLLVGLCLMEQVASPIPLEKHDYSMDCIVCGDGSIHWFQ"
FT   gene            complement(556296..558680)
FT                   /gene="TOG1"
FT                   /locus_tag="YER184C"
FT   mRNA            complement(556296..558680)
FT                   /gene="TOG1"
FT                   /locus_tag="YER184C"
FT                   /product="Tog1p"
FT   CDS_pept        complement(556296..558680)
FT                   /codon_start=1
FT                   /gene="TOG1"
FT                   /locus_tag="YER184C"
FT                   /product="Tog1p"
FT                   /note="Transcriptional activator of oleate genes; regulates
FT                   genes involved in fatty acid utilization; zinc cluster
FT                   protein; deletion confers sensitivity to Calcufluor white,
FT                   and prevents growth on glycerol or lactate as sole carbon
FT                   source"
FT                   /db_xref="GOA:P39961"
FT                   /db_xref="InterPro:IPR001138"
FT                   /db_xref="InterPro:IPR007219"
FT                   /db_xref="InterPro:IPR036864"
FT                   /db_xref="UniProtKB/Swiss-Prot:P39961"
FT                   /experiment="EXISTENCE:curator inference:GO:0003700
FT                   DNA-binding transcription factor activity [PMID:24998441]"
FT                   /experiment="EXISTENCE:curator inference:GO:0005634 nucleus
FT                   [PMID:24998441]"
FT                   /experiment="EXISTENCE:direct assay:GO:0005634 nucleus
FT                   [PMID:26928762]"
FT                   /experiment="EXISTENCE:direct assay:GO:0043565
FT                   sequence-specific DNA binding
FT                   [PMID:24998441|PMID:19111667]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive
FT                   regulation of transcription by RNA polymerase II
FT                   [PMID:24998441]"
FT                   /protein_id="DAA07847.1"
FT                   /translation="MAAKRGLAKQKSRVTKACDRCHRKKIKCNSKKPCFGCIGSQSKCT
FT                   YRNQFREPIEAFFNYTGSLSNDLDNAKCSIAKLKAQLPPSAPASLQKGLANICTELEKI
FT                   QPQLYLNLDSKEISSYGGLKSIETEIIGKQSKSLNRFSNAFESNTAQNVSMYFGVYSPL
FT                   LYFASTGISWITKKLISCSNDRETRETIYLFLKFLDASSASHAGPKVTSISPLEYYSKL
FT                   NGLSCGNDVLIQHIMSNISNEIKGNTNINQTIKFNKPTDWFMYGVQLMEQHHKALDRKS
FT                   SKKLLPLKYFLEQDELIFCLCLEYFERSLFSTMYDLTILKGLVSLMKHRYWIDDPFVLG
FT                   RIISTMSRRSLDAGLNRWEYYIGQDEDTAEEYRKLWWDCYWWDRWYSLVTGKQPLIPHE
FT                   MTSCLFPKDVVGLGVDDSMDCFTLINLVELDPSKFDICISFGYILLTKIITAVFSGLLY
FT                   NRHFTDYRLFATPNAKDLNGTARQLMVEFSKICKIFQCIQDKLIPFLKQYSENSNVFEL
FT                   YTHFGFAKVCCFQGMESLILRIQNLLQERERIELDSCVKDIRLQTFEASVDILTDVLKH
FT                   EDTFYIFRCSWFIYAILMNITLNFIETPRRNSICYLSLMCRMIASYNDLFVSSGNVNFK
FT                   GNNAFSKKLENGTAVSFILTRICCQMYTRSQKMAKESLFCELKKYGQACSDAGQAALDI
FT                   ECIWYRNIIGEHKESSFRKEILSILDREMGDLVNNRVIGVQGKNQEGACYEKLSPSSTS
FT                   VSVGMDFCSLENFVTAESLPDLLNLFWEDTEFGITKENLGE"
FT   gene            559454..560365
FT                   /gene="PUG1"
FT                   /locus_tag="YER185W"
FT   mRNA            559454..560365
FT                   /gene="PUG1"
FT                   /locus_tag="YER185W"
FT                   /product="Pug1p"
FT   CDS_pept        559454..560365
FT                   /codon_start=1
FT                   /gene="PUG1"
FT                   /locus_tag="YER185W"
FT                   /product="Pug1p"
FT                   /note="Plasma membrane protein involved in protoprophyrin
FT                   and heme transport; roles in the uptake of protoprophyrin
FT                   IX and the efflux of heme; expression is induced under both
FT                   low-heme and low-oxygen conditions; member of the fungal
FT                   lipid-translocating exporter (LTE) family of proteins"
FT                   /db_xref="GOA:P40100"
FT                   /db_xref="InterPro:IPR007568"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40100"
FT                   /experiment="EXISTENCE:direct assay:GO:0005886 plasma
FT                   membrane [PMID:18326586]"
FT                   /experiment="EXISTENCE:mutant phenotype:GO:0035351 heme
FT                   transmembrane transport [PMID:18326586]"
FT                   /protein_id="DAA07848.1"
FT                   /translation="MSTTDSGFVLYHYTPSKAAAIVFVVLFIIMTVIFAVQTLYAARKS
FT                   SKALKNNPFESSDDKVDSLEDAEYKQLKITPTVFAFIPFFTGCIMEAVGYIGRALSSSN
FT                   PERTTPYIIQSVLLLVAPALIAATIYMIFGRLLHVMRCQSLILISARFGTTFFVVGDVF
FT                   SFFLQAAGGGLMSKAGSTKTGSGLITAGLFVQVIFFGFFIINEIRFTVNVKRRCLFYED
FT                   ISRKWIFVNATLLLSSMLILLRSIVRIVEFIQGFNGYIISHEYFIYVFDAVPMLLVIIA
FT                   FSVGSFFGNVFDVIKECQTLSN"
FT   gene            complement(561705..562625)
FT                   /locus_tag="YER186C"
FT   mRNA            complement(561705..562625)
FT                   /locus_tag="YER186C"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(561705..562625)
FT                   /codon_start=1
FT                   /locus_tag="YER186C"
FT                   /product="hypothetical protein"
FT                   /db_xref="GOA:P40101"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40101"
FT                   /protein_id="DAA07849.1"
FT                   /translation="MLWHPDGYEPRVKAIEEEIYANEDRKDVPDKFKFDTVTKTGMVKL
FT                   RVFKDDLIFKSQRSINLFASRKHPFKSFTADGEGLPLFAFRTKKPFFVRRDYVGFLFYQ
FT                   YEILKNGDFPEESDYEVKGECDGFTLFKVLFCTVKVKKTSYYRNKERISHILELNFGKK
FT                   EDFRILTLVRCSEIRSVYVVEDKKVIMKWVFTSESKFNLNSSLFIIKAAIGCLPEVGDS
FT                   IEDIPKFDWDSCPTIGCMCRTKEALFQPESRKDMHICPQLFLGETGPPHYNESSVPWLT
FT                   KMNICISVLINFLEYTDFMSWMQDN"
FT   repeat_region   complement(563928..564024)
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty5 LTR"
FT   gene            566230..566655
FT                   /locus_tag="YER187W"
FT   mRNA            566230..566655
FT                   /locus_tag="YER187W"
FT                   /product="hypothetical protein"
FT   CDS_pept        566230..566655
FT                   /codon_start=1
FT                   /locus_tag="YER187W"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; induced in
FT                   respiratory-deficient cells"
FT                   /db_xref="GOA:P40102"
FT                   /db_xref="InterPro:IPR035237"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40102"
FT                   /protein_id="DAA07850.1"
FT                   /translation="MLIDQIVAAVPGVPDISGNASALSLQRRSQEFATSWISMTYSQSY
FT                   GDLAQNWQNDEGGAGNFDSYAEEKLQNFFSGNRDWKYCFAAEDTKNGEPLDYDDIPGDG
FT                   AGTGSAFKSEIYFNTYGGIDNYCNDEHIGAQNTGDGR"
FT   gene            568040..568759
FT                   /locus_tag="YER188W"
FT   mRNA            568040..568759
FT                   /locus_tag="YER188W"
FT                   /product="hypothetical protein"
FT   CDS_pept        568040..568759
FT                   /codon_start=1
FT                   /locus_tag="YER188W"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; conserved across S. cerevisiae
FT                   strains; large-scale analyses show mRNA expression
FT                   increases under anaerobic conditions and two-hybrid
FT                   interactions with Sst2p"
FT                   /db_xref="GOA:P40103"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40103"
FT                   /protein_id="DAA80291.1"
FT                   /translation="MMPTYLGKLTWSYFFTTLGLACAYNVTEQMEFDQFKSDYLACLAP
FT                   EHRNIVVDLASNGFITISPMANATIDFEDVTSDYFNCTDVNTNVQVTIASFYNEYGFGP
FT                   DDNGYYHAMEEPSEFERHDMDVRLYRPYYPGEFVMGRRSDALGVTGFDQKDCAGEGFYD
FT                   EQTAATSCQNIGSTQYAKSVRSYNYGCCGGAVWIRIWPHHNCSKGHDHHFKIRPGQMLC
FT                   WNVNPYSWMQPESGWNP"
FT   repeat_region   568791..569024
FT                   /rpt_type=LONG_TERMINAL_REPEAT
FT                   /note="Ty5 LTR"
FT   telomere        569599..576874
FT                   /note="TEL05R; Telomeric region on the right arm of
FT                   Chromosome V; annotated components include an X element
FT                   core sequence, X element combinatorial repeats, and a long
FT                   Y' element; TEL05R does have telomeric repeats (TEL05R-TR),
FT                   but they are missing from the genome annotation due to
FT                   difficulties encountered during sequencing and/or assembly"
FT   gene            complement(569608..569907)
FT                   /locus_tag="YER188C-A"
FT   mRNA            complement(569608..569907)
FT                   /locus_tag="YER188C-A"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(569608..569907)
FT                   /codon_start=1
FT                   /locus_tag="YER188C-A"
FT                   /product="hypothetical protein"
FT                   /db_xref="EnsemblGenomes-Gn:YER188C-A"
FT                   /db_xref="EnsemblGenomes-Tr:YER188C-A"
FT                   /db_xref="GOA:P0C0V2"
FT                   /db_xref="InterPro:IPR007414"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0C0V2"
FT                   /protein_id="DAA07851.1"
FT                   /translation="MAHLSLNQYKCTHIIMHGTCLSGLYPVPFTHKAHDYPHFNIYISF
FT                   GGPKYCITALNTYVIPLFHHLLSTQFIYTYVNITKKSPLKSPKHKNILSFNDNT"
FT   rep_origin      569618..569695
FT                   /note="ARS523; Autonomously Replicating Sequence"
FT   gene            571155..571523
FT                   /locus_tag="YER189W"
FT   mRNA            571155..571523
FT                   /locus_tag="YER189W"
FT                   /product="hypothetical protein"
FT   CDS_pept        571155..571523
FT                   /codon_start=1
FT                   /locus_tag="YER189W"
FT                   /product="hypothetical protein"
FT                   /db_xref="GOA:P40104"
FT                   /db_xref="InterPro:IPR021646"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40104"
FT                   /protein_id="DAA07852.1"
FT                   /translation="MKVSDRRKFEKANFDEFESALNNKNDLVHCPSITLFESIPTEVRS
FT                   FYEDEKSGLIKVVKFRTGAMDRKRSFEKIVISVMVGKNVQKFLTFVEDEPDFQGGPIPS
FT                   NKPRDGLHVVSSAYFEIQ"
FT   gene            571480..576525
FT                   /gene="YRF1-2"
FT                   /gene_synonym="YRF1"
FT                   /locus_tag="YER190W"
FT   mRNA            571480..576525
FT                   /gene="YRF1-2"
FT                   /gene_synonym="YRF1"
FT                   /locus_tag="YER190W"
FT                   /product="Y' element ATP-dependent helicase protein 1 copy
FT                   2"
FT   CDS_pept        571480..576525
FT                   /codon_start=1
FT                   /gene="YRF1-2"
FT                   /gene_synonym="YRF1"
FT                   /locus_tag="YER190W"
FT                   /product="Y' element ATP-dependent helicase protein 1 copy
FT                   2"
FT                   /EC_number="3.6.4.12"
FT                   /note="Helicase encoded by the Y' element of subtelomeric
FT                   regions; highly expressed in the mutants lacking the
FT                   telomerase component TLC1; potentially phosphorylated by
FT                   Cdc28p; induced by treatment with 8-methoxypsoralen and UVA
FT                   irradiation"
FT                   /db_xref="GOA:P40105"
FT                   /db_xref="InterPro:IPR001650"
FT                   /db_xref="InterPro:IPR011545"
FT                   /db_xref="InterPro:IPR014001"
FT                   /db_xref="InterPro:IPR027417"
FT                   /db_xref="UniProtKB/Swiss-Prot:P40105"
FT                   /experiment="EXISTENCE:curator inference:GO:0005634 nucleus
FT                   [PMID:9837911]"
FT                   /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase
FT                   activity [PMID:9837911]"
FT                   /experiment="EXISTENCE:genetic interaction:GO:0000722
FT                   telomere maintenance via recombination [PMID:9837911]"
FT                   /protein_id="DAA07853.1"
FT                   /translation="MVYTLFQVHTLKFNRKDYDTLSLFYLNRGYYNELSFRVLERCHEK
FT                   ASARPNDSSTMRTFTDFVSGAPIVRSLQKSTIRKYGYNLAPYMFLLLHVDELSIFSAYQ
FT                   ASLPGEKKVDTERLKRDLCPRKPTEIKYFSQICNDMMNKKDRLGDILHIILRACALNFG
FT                   AGPRGGAGDEEDRSITNEEPIIPSVDEHGLKVCKLRSPNTPRRLRKTLDAVKALLVSSC
FT                   ACTARDLDIFDDNNGVAMWKWIKILYHEVAQETALKDSYRITLVPSSDGVSVCGKLFNR
FT                   EYVRGFYFACKAQFDNLWEELNDCFYMPTVVDIASLILRNREVLFREPKRGIDEYLEND
FT                   SFLQMIPVKYREIVLPKLRRDTNKMTAALKNKVTVAIDELTVPLMWMIHFAVGYPYRYP
FT                   ELQLLAFAGPQRNVYVDDTTRRIQLYTDYNKNGSSEPRLKTLDGLTSDYVFYFVTVLRQ
FT                   MQICALGNSYDAFNHDPWMDVVGFEDPDQVTNRDISRIVLYSYMFLNTAKGCLVEYATF
FT                   RQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRN
FT                   IYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASS
FT                   DHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCHEIYMADTPSVAV
FT                   QAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLSRCGCLNVAPVRN
FT                   FIEEGCDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFE
FT                   TEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKR
FT                   SEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIWKKVESQPEEALKLLLALFEIEPESK
FT                   AIVVASTTNEVEELACSWRKYFRVVWIHGKLGAAEKVSRTKEFVTDGSMRVLIGTKLVT
FT                   EGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKE
FT                   GCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIV
FT                   ALPSSFQESNSSDRCRKYCSSDEDSDTCIHGSANASTNATTNSSTNATTTASTNVRTSA
FT                   TTTASINVRTSATTTESTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSNTS
FT                   ATTTESTDSNTSATTTESTDSNTSATTTASTNSSTNATTTASTNSSTNATTTESTNASA
FT                   KEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLG
FT                   FRSDEIKHLFLYGIDVYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALA
FT                   VERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRGEIYSQIQRNYAWYLAITRRRET
FT                   ISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCREEWEA
FT                   KDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQ
FT                   LALGVTPSKVPHWTAFLSMLIGLFCNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLA
FT                   ADNTRVPLYMLMVAVHKELDSDDVPDGRFDILLCRDSSREVGE"
FT   gene            complement(575680..576162)
FT                   /locus_tag="YER190C-B"
FT   mRNA            complement(575680..576162)
FT                   /locus_tag="YER190C-B"
FT                   /product="hypothetical protein"
FT   CDS_pept        complement(575680..576162)
FT                   /codon_start=1
FT                   /locus_tag="YER190C-B"
FT                   /product="hypothetical protein"
FT                   /note="hypothetical protein; identified by gene-trapping,
FT                   microarray-based expression analysis, and genome-wide
FT                   homology searching"
FT                   /db_xref="GOA:P0CX94"
FT                   /db_xref="UniProtKB/Swiss-Prot:P0CX94"
FT                   /protein_id="DAA07854.1"
FT                   /translation="MMPAKLQLDVLRTLQSSARHGTQTLKNSNFLERFHKDRIVFCLPF
FT                   FPALFFVPVQKVLQHLCLRFTQVAPYFIIQLFDLPSRHAENLAPLLASCRIQYTNCFSS
FT                   SSNGQVPSIISLYLRVDLSPFYAKIFQISYRVPMIWLDVFQVFFVFLVISQHSLHS"
XX
SQ   Sequence 576874 BP; 176533 A; 109826 C; 112313 G; 178202 T; 0 other;
     cgtctcctcc aagccctgtt gtctcttacc cggatgttca accaaaagct acttactacc        60
     tttattttat gtttactttt tatagattgt ctttttatcc tactctttcc cacttgtctc       120
     tcgctactgc cgtgcaacaa acactaaatc aaaacagtga aatactacta catcaaaacg       180
     catattccct agaaaaaaaa atttcttaca atatactata ctacacaata cataatcact       240
     gactttcgta acaacaattt ccttcactct ccaacttctc tgctcgaatc tctacatagt       300
     aatattatat caaatctacc gtctggaaca tcatcgctat ccagctcttt gtgaaccgct       360
     accatcagca tgtacagtgg taccttcgtg ttatctgcag cgagaacttc aacgtttgcc       420
     aaatcaagcc aatgtggtaa caaccacacc tccgaaatct gctccaaaag atactccagt       480
     ttctgccgaa atgttttatt gtagaacagc cctatcagca tcgagaggaa tgccgtccaa       540
     tgcggcactt tagatggggt aactcccagc gcaatctgat ctcgcaagtg cattcctagg       600
     cttaattcat atctgctcct caactgtcga tgatgcctgc taaactgcag cttgacgtac       660
     tgcggaccct gcagtccagc gctcgtcatg gaacgcaaac gctgaaaaac tccaactttc       720
     tcgagcgctt ccacaaagac cgtatcgtct tttgcctccc attcttcctg gcactttttt       780
     tcgtcccagt tcaaaaagta ctgcagcacc tctgtcttcg attcacgcaa gttgctccat       840
     actttataat acaactcttt gatctgcctt ccagacatgc ggaaaacttg gctcccttgc       900
     ttgcctcttg tcgaatccaa tacactaatt gtttctcttc ttctagtaat ggccaggtac       960
     caagcataat ttctctgtat ctgagagtag atctctctcc tttttacgct aaaatatttc      1020
     aaatatccta cagggtcccc atgatatggc tcgatgtctt ccaagtattc tttgtattcc      1080
     tcgtcatttc gcagcattct ctccacagct agtgcttccc aagccatcct cctatacgat      1140
     actttctggc cagcccaaca gacacagagc tcgaacatct tttgacagcc cttgcataat      1200
     ccgtattgtg tgaatacgcc ctctgggcag aagtatatgt caataccata gaggaaaaga      1260
     tgtttaattt cgtcagaccg aaatccaaga aactgtaaga cattcatatt ctcggaagta      1320
     ttgggaaatt gtgctttcag tttctttctc tctagcaaaa ccatttgact ccctttccgc      1380
     ttatacgact ctttgttaat gtcggtgact ggatggaatc tattatcctc agcattgcca      1440
     tctttattgg cgtcctcctt ggcactagcg ttggtacttt cagtggtagt agcattagtg      1500
     ctggagttgg tgctagcagt ggtagtagca ctagtgttgg agttggtact ttcggtggta      1560
     gtagcactag tgttggagtt ggtgctagca gtggtagtag cactagtttt ggagttggta      1620
     ctttcggtgg tagtagcact agtgttggag ttggtgctag cagtggtagt agcactagtt      1680
     ttggagttgg tactttcagt ggtagtagca ttagtgttgg agttggtact ttcagtgata      1740
     gtagcattag tgctggagtt gatactttta gtggtagtag cactagtcct gacgttgatg      1800
     ctggcagtgg tagtcgcatt agtgctggag ttggtacttt cagtggtagt agcactagtc      1860
     ctgacgttga tgctggcagt ggtagtagca ctagtcctga cgttggtgct ggcagtggta      1920
     gtagcattag tgctggagtt ggtagtcgca ttggtactgg cattggtagt cgcattagta      1980
     ctagcattgg tagtcgcatt agtcctgacg ttggtactag cagtggtaat cgcattagta      2040
     ctggcgttag tactggcatt agcactacca tgaatgcacg tgttgctgtc ctcatcactg      2100
     ctgcaatact ttctgtacct gtcactgcta ttgctctcct ggaagttaga cggtaacgca      2160
     acgatcgaca tggaagctgt cgcctgtttt tcagccaatc tgtccattct ttctatcagt      2220
     tccactgtgt cagcagacag gtctgtcctg gagccacagc atccaacatg ctggcccttt      2280
     tttcctttct ttgattcaag tccatagaac tcgcgtacct gttcggttat acagccttcc      2340
     ttaattggtg gtaattcacc cttacgattc cttgccgccc aactgttttt tctagataat      2400
     agataacaga ggcccccatc tcttagtctc cctacgcctt gaatgagctc aataatatta      2460
     agtctattat caagcatgat caccatcatc aattgcttaa tgtcaattcc ttcagtcact      2520
     aatttcgttc cgatgagaac tcgcatgtta ccgtccgtga caaactcctt tgtgcgagac      2580
     accttttctg cagcatccag cttcccgtgt atccatacca ccctaaaata ctttctccaa      2640
     gagcaggcca attcttccac ttcgttggtt gtgcttgcaa ctacaatggc cttcgactct      2700
     ggttcacttt caaagagggc taaaagaagc ttcagtgctt cttcgggctg tgattccact      2760
     ttcttccgaa ttttatgaac atgccctaaa ggcacctcgg atttctcctt gattagatta      2820
     aacatccgtg ttggatagct ggatagacct ctgctgagat cttccgaccg tttgagctcg      2880
     ttgatgtcca tcgatttctt ggccagtccc gtaagcccaa tacgctgcaa cgcagcatca      2940
     gctacagcct caggggctgt gccgctcaaa aagattgctt tctcaaaagc gtcaaaatca      3000
     aggttagtta tgcccccaaa ttgcgactgc cggtagacct ccgtttcaaa gttgtgaaac      3060
     tcatctacaa tgaggtaacc caattttacg ttgttggtcc taaaggtgca ctcaacaata      3120
     ttctcccacg cagctatcct gtctgtgaaa ttagtgctag caagatcatc gtagatcccc      3180
     acgtataaat cagtaacgcc atcgtaacct tcttcaataa agtttcttac aggggccaca      3240
     ttcaagcaac cgcatcggcc caacctgatc atgcaattag caagcaacac tgtgtacggt      3300
     acaaacagaa acgacacata tttcacgtcg cccttagacg ccagtgctat caaggggaga      3360
     tgaaataact ccgtcttacc atagcccggt ggggcctgta ctgccacaga gggtgtgtct      3420
     gccatgtata tttcataaca taagcgcaac tgatgcaagt ccctgaattc aaaggagctg      3480
     ccaaagagtt tctggcctgc aacgaggata tcgtttgtac tcttgggctc tcggggcctt      3540
     tttcgcgtta ctcttgagat tttttggtga tgatctgaac tcgccgcctc acctgccact      3600
     acgtcttccg cattccgagt actagagaat gaacaatggt agtcgctttc aaggcctaac      3660
     cattgaatcc agcgctcgga agctcgttcc tgcaataaag tggcggtcgt cccactgaca      3720
     ctagttaacg aaaaggaatc cacaccgtaa atatttcgcc ctgtttgaac ggaatgattg      3780
     gccatgagtt cactcgtcgc cgactcgtac aaatctgttt caaatctgct acctacgcag      3840
     tgccgtccta gggcaatcaa cccctgacgc atctcccgaa aattcagctt ctgaggtgca      3900
     ttcttcggaa gttccctcat gtactgccga aaagttgcgt attcaaccag acagcccttc      3960
     gcggtattca gaaacatgta ggaatacaaa actatcctcg aaatgtctcg atttgttact      4020
     tgatttggat cctcaaatcc caccacatcc atccaaggat catgattaaa agcgtcataa      4080
     ctgttaccaa gcgtcataac tgttaccaag cgcacatatt tgcatttgcc ttagcacagt      4140
     gacaaaataa aacacgtaat ctgaagtgag tccgtcaagc gtctttagtc gaggctccga      4200
     tgaaccgttc ttgttgtaat cagtgtacag ttggatgcgt cttgttgtat catcgacgta      4260
     tacgttgcgc tgaggaccgg caaaagcgag tagctgaagc tctggataac ggtaagggta      4320
     tcctacggca aaatggatca tccacataag tggcaccgta agctcgtcaa ttgcaacagc      4380
     gactttattt ttaagagccg cggtcatttt gttagtatct cttctcaact tgggcagcac      4440
     aatttcacga tatttaacag gtatcatttg aagaaaagaa tcgttttcca gatactcgtc      4500
     aattcctcgc ttcggttctc tgaacaaaac ttctcgatta cgcaaaatga ggctggcata      4560
     tggaagcagt tgttcaactc tccccaaagt tttccacata ctgatatacc atcagaagaa      4620
     ggtaccaaag ttattctata agagtccttc agcgtggttt cctgcgctac ttcgtggtac      4680
     agaattttga tccatttcca cattgcaacg ccgttgttgt catcaaatat atctaaatcc      4740
     cttgcggtac aagcacaaga cgacaccaat aaagctttca cggcatctag tgtttttctg      4800
     agtcttcgtg gagtgttagg actgcgcaac ttacatactt tcaggccatg ctcgtccaca      4860
     gagggaataa tgggttcttc attcgtaata gatcgatcct cttcgtcacc agcgccacca      4920
     cggggacccg ccccgaaatt gagtgcacat gctcgcaaga taatatgcaa aatatcaccc      4980
     aatcggtcct ttttgttcat catatcgtta catatctgtg aaaagtactt tatctcaatg      5040
     ggtttacgtg ggcatagatc acgcttcagc cgctctgtgt cgactttctt ttcgccaggt      5100
     aaacttgctt gcatagctca tctacgtgta ggctgccaaa ttgtacccat atttccttat      5160
     ggtgcttttc tgaagactcc ttacaatagg tgcgccggaa acaaagtcag tgaaagtacg      5220
     catcgtagag ctgtcgttcg gcctagcact cgctatttcg tgacaacgtt ccaggacacg      5280
     gaaactcaac tcattatagt atcctctgtt gaggtaaaaa agagaaaggg tatcgtaatc      5340
     ctttctattg aatttcaaag tatgcacttg aaacaacgtg tagaccatca cgtggtttgt      5400
     ttgaagggat tggtccgccc tggaaatctg gttcgtcttc aacaaacgtc aggaactttt      5460
     ttacattttt cccgaccatg acggaaatga caactttttc aaaagacctt ttcctatcca      5520
     ttgcaccagt tctgaatttt accactttga ttaggccaga cttttcgtct tcgtagaatg      5580
     accgcacttc cgtggggatc gattcaaata aagttattga gggacaatgt accaagtcgt      5640
     ttttgttatt tagagccgac tcaaactcgt caaagtttgc tttttcaaac ttacgcctat      5700
     cggaaacttt cattttattt ttgtaagttt cgaaattaac aatagtatgt tgattgttat      5760
     gctttttgac aagaaatcca tcaatataaa caaaagattg tccagtttcc gtcttatcat      5820
     catctaagaa tgtaataatt aagctattga gaagatgcag aatctgcgct atgcaggtgc      5880
     agcaaaagca aacaaaatct cactaagata agcgactgtc tgtccccttc aagcacaaca      5940
     tagaaaacag aaggatgtct cattcatcgc ttgatttccg gcctgcaaaa ataaagtagt      6000
     cggtacgtac gttcgttttc aatttccatg gtgcacagta tcttaactat ctgcttagtc      6060
     gaggagaacc aggattctgt tcgttgctca gccgcttcgt ggatattctg ttggatactt      6120
     taaacatgga cctacgttcc gctctcgaaa agaccaatat aataaaaagt tataaattac      6180
     atttccttat taggtatacg acctcgcgct tcgaagtaaa ggagcccttt ttggcgtacc      6240
     tacatatggc gcgtcagaaa gacaaacttc tcccaaaatg tattaccccg ccgaataaga      6300
     aagcagaccc attcaccaac gacgtatcaa gttacttcac ccacacccac acccacacac      6360
     catgctcacc ttcacttgta tacacttatg tcaatactac agaaaaatca ccatcaaaat      6420
     cacctaaaca taaaaatatt ctacctttca acttcacgaa ataaacactt tgacttgaag      6480
     tatgaatact accatggcgt cattaactta aaagttcctt aatatcgtca tacctctata      6540
     ctctattcaa tatattgtaa tataaatgca ctctatagtc atacaaatac ttttacttca      6600
     ccctatcttc gcataccatt gtcatagaat ctcacactga cgcatgatta aaacgaataa      6660
     ttttactata aggcctccca tccgtgctct atccttttgt ttgcaatatt tatatacaga      6720
     atctcaaaac aagcgggaga agtggtaatt acccagaggt catgcatgat cttagcacca      6780
     ccgtacctct atgaagctgc acaaatgtta tatatcatac caggaataca cataagtgca      6840
     aatgctattc tacaatatcc tcatcttacc agctcactca caaaatattc ttactccgag      6900
     tacgaccata aagcaatgcc gacgaatagt catactaagg tactataaaa tctttccgtg      6960
     cgcttaagcg gacaccatgc cataatgtta aatgtaataa tttaaaagca tcataagagt      7020
     aattttccag tattgcttca gtaatgcaag gcctaaagaa gaacgcattt tggtatggta      7080
     aacctccaac ctactagtaa ttaaaaagct ttagtttaac ctgcagttcg ggacacactt      7140
     cgggcataac gtacgtttat tataaatttt ttatatctct tgcgtaccca tgtatattcc      7200
     agaacagtca atgcactttt gtgagccatt tatgctactt tcatattccc cattaaaaca      7260
     ggtactactg ttgaaaaggc ataataacct gaagtttcgt atgggttagt tacactaggt      7320
     gaaggatcgt ttgcctccat atggtcaagc cattcgcgga cattgataat agctgggaca      7380
     attctggttt cataaagggt ttcattcatc cagattacgg atacattcaa atagtagtcg      7440
     ccaaatcctg atgcctcatc aaaatgaaaa tatgtctcta acggaactgt attagaccat      7500
     gcgctcagcg tagctgcagt cgcgttggtt aaaacgttag ctaagtttac catcgtgtta      7560
     gtagatgatc tgttatttcg ttaatagata actttacaga agcaccatct cgctaccatt      7620
     tatacgcttt ggaataaaaa tcagcccttg taaatttcac atgctcgacc gtttaggaga      7680
     ttatgcattt taagtcgttc attaatatta ctgtagcgag gaagatgatt attgatttcg      7740
     aggggtataa tcatatgcgg cgtgaaaaat aatgacttgg gttggaagcc gttaggatag      7800
     tatttatact gtcacgaaat ttacaggaag ttgtaaatat gttgcataaa atttttgata      7860
     gcaaagccac cgactcttca ttatggagtt ttttttctct tattctcctg ttgccttcgt      7920
     actgtaaacc ccagtcatgt aaaatgccat atggaggcta gaagaatgaa aaatcaattt      7980
     atattttata atacagtgtc aatattgatc gaaggatgca taatatatac actggattga      8040
     ccattcgaat tatatatcta tctattctat acatccgtgt aacttagtaa gaaccagaca      8100
     ccaaaattat ttttttatag aagatccttc ttgtctttca tgtacctctt tcagatacca      8160
     ctgagtaata tgactttaaa agctctactg atatcattta tgtattaaca tgtctgaaca      8220
     ataagtatct ttttaactgt ataagaaagc atgagaattg tttcaaaaac ctctcattta      8280
     tatatggaag gaaattagag aaatattgtt cgtagtgtat tccttaaatt tacggcagga      8340
     agagttaaaa agaaaataat tcaagattct ctacttaaat taatgcatcc tttccattaa      8400
     tagtttataa ctggcgcgat gcaatacact ggaaaaaatt aataatagtt ataagtacga      8460
     gaaatatcta ctcctaaacc aaataatgtg acataaagta tacagcaaat atctcttcaa      8520
     gtttaatttt gatatggcta aaaaatgctt attcgggatg gaagtgaagc aactagccta      8580
     ccaaacgcaa ccattttaaa aaagccacca gcatccattg cataacaagt cacagtctgc      8640
     tataaacgtt tcagggcaat gctcacagtg agcacaagca ctaacaattt ttaaataatg      8700
     tctaactcac cataggccac actataatgg cctgatttcc ctcaatatat gtggctgttg      8760
     aatttgcaga tcatcaccct gtgcgtttta caagatattc cttaatagaa caatctaaat      8820
     tattctattt gaaaaaaatg aacaataatt aacacgagaa tttaaaccat actcggccgg      8880
     attagcgatc atttcgttag taattaaaat taacatttcc atgtgggact ctaactgctg      8940
     catcgccaag ttgataagcc atgaaatcac caatatcaaa gatagcaatc caactggaaa      9000
     aattattctc ggcatatggg tgatgataaa aagcgtagct taacaaacac cagtgctggt      9060
     tattatctgt aaaatttgat tagatttcaa gggaaaatct gtttgaaatt gcgtttcctt      9120
     gttggcctgc catactttaa ttgaataaaa gctccgtata tgcttcttaa aaataagcaa      9180
     tagatccagc tgactcattt cctgtatttc taaggggaaa tgcgtaggga agaccaattt      9240
     catgacgata gattgaaacg gcaatcaaca tctgaagaaa agaaagtagt atgacagctt      9300
     gatgtcttat ctcatttact actttaatga cttcgtacaa cttcactgag ctaatttacg      9360
     ccatttttac gcagattatg atattcattt cttgagatat gaggtcgact ggcaatgcct      9420
     actcttataa agagaaagtt tttgaaaaca cagtacgttt acaaaacgat atcaatgaag      9480
     gttgtagcta catgctcttc accagactaa tatatcctct tagtaaagcg ctatataata      9540
     gtaactcaat attttgtaaa tacaataagg ttaacggcgt tattcatttt cgtctgatat      9600
     tcatttgcaa tttgcagttc aacttttcaa tgatgattta gaatgatcta acactggaag      9660
     ttgaagtttt tcaaaaattt gctgtaaaat ttgaccgatt tgtgagattc ttcctggctg      9720
     tcagaatatg gggccgtagt atattgtcag acctgttcct ttaagaggtg atggtgatag      9780
     gcgttgagta tgtgtagtgt ttgacccgag ggtatggttt tcacaagtac tgcgcactgt      9840
     attgtgaaag cagcttcggg gtgcgtgatt aaaaaatgcg accaagaata aacaggtaca      9900
     tcataacaag ggccatttga attgcattta tcaggatttg taaccttgtt ctaaagaggc      9960
     atcgtatagt ttaagttcat tttccaccca atttgatgac ggtgtggacc ttaacctatt     10020
     gtcttgaaat ttaggttatc tcttagatat cacatgtgat taccccagtg aacgcgtata     10080
     agcttacaga aaggaaaacc ggttggctca gtcaaaactg ttgcagattt gggctcccct     10140
     gaatatttga gacatcccta aaatgaagag atatatacag ctaattttga atgaaaattt     10200
     aaaattcgca atgaacagta ctagagatga gcttttgaag tcctttcaaa ttatttgttc     10260
     ttccagttga tattttttat tttatatacc agtaccaaat ataatcttgc catacattta     10320
     cctttttgag gttgttcaac ggaaatccag tgtatttaca cattcttgga aacccatcgc     10380
     ttataatacg aactaattta tttatgaaca aaggctttgg aaaagtatcc ctacttttta     10440
     cgacgctaaa tcatgatacg aaactttagg aagattaaca gtcactccat aaaatcagaa     10500
     agtattcgct aatagtggaa agaaatggtt atataaagat ggaaatatct tgaaagagac     10560
     agtttaaccc gaagttctgt caaagtgttt gatttgaatt gaatagtatc acagaatgcg     10620
     ttagctatgt acaaagaatc tatcggcaag tatggggtag caagctgctt aaagcttctt     10680
     atcacactgt aacctctgtt aaagcagctg cgttgttctt gcactctgca cgtaaatgac     10740
     gacggccaat gtaaaaatag cagtcactgc aggcctcttg gattgtaccc gtaattacag     10800
     caattgccat tagatttacg aagtcattta attaaatggt ttgatttatc tccttaaatg     10860
     cttccagaaa tgggactaga cttttttcac tcaaacctgt tcacaattat tgctcttttt     10920
     caattataag gtaaacaagg ccatctatca gcaacacagt gctcgcattt tttaattaaa     10980
     ctatataaaa ccaactattt gtggttgcga cttcactttt tgttgaatta ctacccaatc     11040
     attaatattg aagatgtgag atcatagatt tattggcttt gggcatctca aatcccaaga     11100
     ggtcatttta accaacaaca ttttaaaaag tagatttgtc tgcctcagct atgagatgcg     11160
     catgtcccta gcatctcata tctggttata ttattttttc cacttggtga atgttgaaaa     11220
     aaacaccact cgtccaattt atcagtttgc aggtctaatg tccttccctg ttatttaaac     11280
     tgtatattgt aagcatgtct tatcgaaaca acttactcag ttgtccgaaa acaaaactgc     11340
     aaattctgtg tgtattcacg tactagaatc ctgtcaaatt ggatcttgat ttaagctttt     11400
     atagcaacga actttgcata ctaagttttt tttgttaacc ggaactgcca agaagcattc     11460
     agtaaaatac atcttcatca tttactgata atactcattc agactcatat catactattt     11520
     cgaattcatt atacatcctc aaaaaccata ttcttcagtt gtaataaaag atagagcctg     11580
     catttgattc gatttccgta atttgggggg ccaagtccta ggttgacttc atcttggatg     11640
     tctatcgcga tgcatttagt gtggcataga atttctctct tcacgagcag ggaaggaatt     11700
     gtattatatt atttggtaat cgcctagtca cagtcattta gaagaaactt agcatcatta     11760
     ttccagcatc atgcaccaga acaggaaaat gccatttcta aaagtattct catagccatt     11820
     aaacgattca atactttttt ggtagctaag tcaatgcctc tctgaatatt gtatactata     11880
     tgaataaagt gatcccataa tcagactacc cagcacttag tagcgcattt tagaactaaa     11940
     tatatattgc ctttttaata ctgtaacttg agaattctta ataaggaaca acaatggtcc     12000
     agaaggtgtt cggtagaaag atagaaaatt ttaaaccata cactatcaag caatattata     12060
     cttgttcttt aatcaagagg ggattgtact tttatttgat ttgaggccgg gtatcttgat     12120
     ttcacttatg ttatactgtc tcttagttga taaattcaat gttacatttg ctatctcatt     12180
     ttcaggtcag cagctatatt gaccttgctt acattcagcg cgtgtgaggc actaccttta     12240
     aaactcttgt gctccttatt caccatagtc tgttatccgt ttgttcttac ggaggaaact     12300
     gcaattgatc atttatgaat cttttagtga aatttagaca ctattaaaat ttaataatag     12360
     gcaaagtacg tcaattatca ttcttggttc ctgaaaagtt gaatctgtta tgaagtctga     12420
     tatttggggt tagcattgta tacttccctt gagtaatgca ttatccgtaa cgccactttt     12480
     accatattca agtgcaggta tatttagcat tttttacata taatatactg acctccgaag     12540
     ctaggtgaga gaaagcaaag gttttgaggg ctattttcac cattggaact aagatcgtac     12600
     acactaatta actctctgcc ggaggcgcgc gatatatggg ctggagcggt cctgactaaa     12660
     gtcctgctgg aatattggtg aagtgtctca aaaaactagt aaggtcaata tcagggaagg     12720
     aactattatt ggccgaggcg gcagctaggt taaagaatct agccgtcaat gcaacgaagg     12780
     ttatcaagta cattcagttg gatacattaa aaaagttgaa tacaatatca attctagaag     12840
     attgtagcaa gtttggtgag atagtttacg cctataatat ataagtgcta actcaatgtt     12900
     cagttagtag aatcacagcc tgaatattct gtgcatcgtt tactcaggga cagatgcgat     12960
     ctcaatgcag ggacgaaaaa cagtcttata tgcgcacgcc agcaaaatct ttttttgcgg     13020
     cacctaagat ctctcgcatg ataaaagcat aatatctttg ccccacaaag tcaaggcgta     13080
     ttggaaaagc tactttagtt aataatgaaa tgatcgccca tccgggtaaa aatggttaca     13140
     attccagtgt tgattattgt tcgtttttca gagagaataa tttagatgct cctattgaag     13200
     aatatcttgt tagcgcatag ggcaatcatc tacgacttta accgcaactg cgtctgttac     13260
     cgacattgga ggattgtatg ctcaaatgac ccctgtggtg aagatgaaca cttcttgcac     13320
     actatggttg aatcttgacg gtaccctcac tcagagtttt atagtatcac acgacgctac     13380
     tctcccgctt gtacattcat tctggctagt ttataataac gttaaggaaa tgacacccat     13440
     acctctcaga aatccaattg gaaataatat ttgtaaaagc acgtgatatt gcctttttct     13500
     tttatctggt taccaatatg ggatcaataa ctttactttt gaagatcttg tttttccttc     13560
     agataagaaa tcaaaaaaag aatatatgca caaaacagta tggatataat acaccttact     13620
     cttggtcgtg attgaaaacg taaggttcta cataaattat tgagaaagac ttatttgaag     13680
     atatcgagag tctatcatgc cctttgcaca acaaaactaa tgtcagcttg cccttgcaac     13740
     atcgttatac tcccagtcga gattttgaag aattcatcta aagatactaa gtatagcttg     13800
     tatacaacaa ttaatcgagg atatgatgtc ccaagactca aatatggcat catagttagc     13860
     cctcgagtgc acagccttga gactttattc agtgatctgg gctttgacaa gaatatagag     13920
     aaatcctcgc tttacttatt attaaatgat cctaccttag cataccctaa tttccatgaa     13980
     cattttgaac agcttaaagg tgaaacaaac aaagatttat ctctaccgac atattatatt     14040
     ccgaaggtcc agtttttgac agaggcattc gattcagaac ataccctagc aaccatcggc     14100
     tacaaaccaa ataataagga gagttatgag atcacaggtt ttacatccat gggtaatggt     14160
     tatggtataa aactattcaa ttacagtgta attcatatga tgcggtctca taagtgtaaa     14220
     agagtggttg cagatattat catggagcat gacctattgg gttactatga aaagaagctt     14280
     ggctttgtag aggtgcaaag gttcaaagtt ctcaaagaac agcaccaagt aaaggtattt     14340
     gacgataaag ttgactttac caaagacttt catgtgatca aaatgattaa agagttggga     14400
     aatcatagat tgtagtggta tagtcccgta cacactctat ttgaataaac tgtaggttct     14460
     gctgagcaac atattgatat aaacagtaaa aagaagtggg ttccttgttt tcctgcaatt     14520
     ataactaacc gtgcttacta ccaaaaaaaa agtgcgtata aatattcact atttacaatg     14580
     ttgaaggttc cagatggata cagaatagga atcctaaata taaacactat atttatttat     14640
     ttttttcgaa taaaagtcat gttagcaata tttatatagt tgattttcct gcatttatta     14700
     tataattggc ggcatagtaa catcaaaaaa aaaaaaaaaa acattcaaat tgcactactt     14760
     atagcagtag catctataaa agttttatga tataaacctt tacagttatc tcaaatggtt     14820
     ttgggattgt ccatcaaatc aagcgtgatt catctatacg ttattattct cctacaaccc     14880
     ccttagtttg gagagcgctt agagaaataa agcatcgatg ttttcttacc ttcactaaaa     14940
     tcaaaataaa aaagcttttc tatagttcac gaattacgca atttattcta tcatccttaa     15000
     agttgatcaa ttgcgatttt aacacacatt ttcaaatgtc attttgcgct tgtataatag     15060
     gtgccatctg gacactttat aaaaaataaa ggaaaagtaa aatataatgc tgaaaatata     15120
     gttgccttaa aatgccattg atatgatttt tttttaacct taaatctatt ggcctataat     15180
     attcgcggca aaatgagcat ttgaaaatca gtaatagaat gctatcaaac ttcgttcatg     15240
     acctttttag catcataagt gttgaatcga atctatcagt tcagtaatta aaaatactat     15300
     ttttctgtca gcacagaacg taacgacttt tccttatatc cactattgat ttctctttaa     15360
     agtgctatgt aaagtaccta aaaaacttgt tatagaagtc tcattcgaaa gcatgtgggc     15420
     tcaaaaattg tgaataagat acatagaagg agccgctgat cgacacataa tagtagagtt     15480
     gaacctagtt ggttcaacca ttatcatagt tatacgaata aagccacaat ataaatggcc     15540
     aaccgctgtt gtcaaacaag actataggtt cattttaacc tggcgtgcag tacgctggtc     15600
     ttgctaacgc ctctacaata cgtacagtgc aggttttgac gaatgaaagt ggttagaaga     15660
     ttaatgtgat agaaacaaga attttctcgc aaagatctgt atgaaaggaa acgtttggta     15720
     agaactctgc gatccaaatt ctactgaatg aatagaaggc ttctacagaa caagttgtat     15780
     cgaaatgatt gttggcgact actatatttc tataggcatg aaagttactc ataaacagga     15840
     aagacgcatt ttagtagctt gacctggtca gattaatcag cttccaacgt tacttccctt     15900
     tcgcaagaat ctacccaaaa tgtctcgagc atcttgataa ttacagtatc gttcgtcccg     15960
     acttggcatt tgtttaaatt tctaagatgc ttcctatagg aacataattg tcaagaaagc     16020
     acaacaaatt gtctgcaatg tcaacaggag tggcgcattt tatgtttttt catttttttt     16080
     tttttgtgcg tgatcattaa gcgggatatt gtccacagtc atctaaaaga atgaccattt     16140
     cgacgactta gttcggaaaa tatttccagc ggatgacacc acttgccaca gttggtgacc     16200
     gccaaatcta agtcacgcgc ggaaactgaa aggttgtgag tatataagtg atcactcgct     16260
     tatataactg acgaggcaga acagggtgcc aaaatgctcc tcaatatttt attcatttga     16320
     gattcaaggc ttaaagacag catatataag aattatgacg gccgcacatc ctgttgctca     16380
     gttaactgcc gaggcatacc ctaaagtcaa gagaaaccca aatttcaaag ttctcgactc     16440
     ggaagatttg gcgtactttc gttcgatttt gtcaaatgat gaaatcttaa actctcaagc     16500
     tccagaagag cttgcttcgt ttaaccagga ctggatgaaa aaatatagag gccagtccaa     16560
     tttaattctc ttgccaaact ccactgataa agtgtccaag attatgaaat actgtaacga     16620
     taaaaagttg gcagtagtac cacaaggtgg taacaccgac ttggtcggag cctctgttcc     16680
     ggtatttgat gagattgttc tttctctaag aaatatgaac aaagtcagag attttgatcc     16740
     agttagcggg actttcaagt gtgacgcggg tgtcgttatg cgtgatgcgc atcaattttt     16800
     acacgaccat gaccatatct tcccattgga tctgccttct agaaacaact gtcaagtggg     16860
     cggtgtagtt tcaacaaatg caggtggttt gaacttttta agatatgggt ctctacacgg     16920
     taatgttttg ggtttggaag tggtgctacc caacggtgag attatcagca atatcaatgc     16980
     cctaaggaag gacaatactg gttatgactt gaaacaatta ttcatcggtg cagagggtac     17040
     tatcggtgtc gttactggtg tatccatagt tgcagcagca aagccaaaag ccttgaatgc     17100
     cgtatttttt ggtattgaga atttcgatac cgttcagaaa ttatttgtca aggctaaaag     17160
     tgaattatct gagattttat ctgcttttga attcatggac cgtggctcca ttgaatgtac     17220
     gatagaatac ttgaaggact tgcctttccc tctggagaac caacacaact tttatgttct     17280
     tattgaaacg tcagggtcca ataagagaca cgacgatgag aagctgactg ctttcctcaa     17340
     agataccaca gattctaaat taatttcgga gggtatgatg gctaaggaca aagccgattt     17400
     tgatagactt tggacctgga gaaaatctgt tccaacagct tgtaattctt acggtggtat     17460
     gtacaagtat gacatgtcac ttcaattgaa agatttatat tccgtatctg cggctgtgac     17520
     ggagagatta aacgcagccg gtttgattgg tgatgcacca aaaccagttg ttaaatcatg     17580
     tggttatggt catgtcggtg acggaaacat ccatttaaat atcgcggtaa gagaatttac     17640
     aaaacagatt gaggacttac tagaaccatt tgtttatgaa tatattgcat caaagaaagg     17700
     ttccatcagt gctgagcatg ggatcggttt ccataagaaa ggtaagttac actacaccag     17760
     aagtgatatt gaaattagat ttatgaagga tatcaaaaat cactacgatc caaatggaat     17820
     cttaaaccca tacaagtaca tttgaacttt gttaattttt aactttcaaa gagcaaaccc     17880
     tttttcttta cagtattata gatttacata tatgtattta tcaatttatt attgatcaaa     17940
     attaatatac cataaaatat ttatcttaag ccgttgttct tgaacgattt tcggtgaaga     18000
     aacctaagag accatttttt gtggaaaaag gtctcgtttt ctatagatct gcgaccagga     18060
     atctcctgat tgcgtacttc aaaaagtgtt cgtccatttt ttctttacta cattagataa     18120
     ttatacataa tccaattgga gtagtgacat gagtattggt ataaccttaa tccaacaatt     18180
     ttaaacacgt actaaagtga tctggactca ttaaaactca aatctcgtcc agttttttct     18240
     tcatttgtga tcaacatcca gggagacacg gagattatag tagtagttaa taacacttcg     18300
     caattactta ttcaagtatg ttattaaata gtgaagagga atgagttttc agatcacatg     18360
     ttattctcca agaataatta cataagttgc catttcaaat gtgcgcaaac taccttctgt     18420
     attctttgcg ctaatgcctt actcagtctc ccacttttaa cgtttatttc ttgtaagagt     18480
     cgaaactaaa ccttagttga gcttaaattc aatcaagttc aagaagcgtt ctggcccaca     18540
     ctttaaagcg actacaatta ggaagagctc actaggacca acgtattcaa tgtggatatc     18600
     atgaaaaatt tcatctccaa aaagccaaaa ttctactcat aatgacagtg gtgagaatta     18660
     gcaaggtaaa atattggcat tatgtggcag gagaagggaa atacgagagc ggagataagt     18720
     tggatattaa tgagctttag atgttgaaaa aaaaagaaag cgttacaatg ctcaataaaa     18780
     caatgacttc ccggaaaaga ttttttgatt attttattcc gagaaaggcc gatgtatgct     18840
     gaaccaacgt gttgcttgcc aacttcagca tactttgttt gccaccctac taggaagtga     18900
     ccccgagaac tttattttct gcacccatgg gtgcctaaaa cttatttttc tgcagggcgt     18960
     ttgagaaata agggatatgg caaaaatcga aacgtggggt agtttcgtgc cttcttatgt     19020
     gcctatcttg atttttgcct ttgtgcctta ctctccttac cccgcgatac cccaccgtat     19080
     atttactctc tccttggcac ggacctaaaa ataactgtag aatgagctca acaaacaggt     19140
     aactttacgt aaactgttct ttttatcttt cagctcgcca ttttctgatg cagtacatag     19200
     aactgtgata cgtcattata tagacttttc gcacacacaa ccaattaagc ttgcgcatca     19260
     gtggtggata tatggacgga tacctcgtat attctgttgt tgtcgtggga gagggcatcg     19320
     caaagtctag aagtaattaa attactttca gcgtttccaa atgagttcga gaacaattat     19380
     attctagggg gaaggaggtt acagcggttg cagactcata gttccaaatt ccatttattt     19440
     tttacatata aatagccaac atttatcatc caattgttaa gattttcact ttgtctagat     19500
     ctttccctag atcttcaata aaaataaata aaaataatca aagaaaagga aaaagaaaaa     19560
     gtaacaattt aaacaaaaaa aaaaaaatat gacaaaatca gacgaaacaa cagctaccag     19620
     cttgaatgct aaaactctaa agagttttga atcaactctt ccaataccaa cttacccaag     19680
     agaaggtgtt aaacaaggta ttgttcatct gggagtcggt gcattccacc gttcccattt     19740
     agctgttttc atgcaccgtc tgatgcagga gcaccactta aaggactggt ccatatgtgg     19800
     tgttggttta atgaaggcag atgcacttat gcgcgatgcc atgaaggccc aagattgcct     19860
     atacaccctt gtggagcgtg gtatcaagga cactaacgct tatatcgtcg gttccattac     19920
     tgcttacatg tacgctcccg atgatccaag agctgttatt gaaaagatgg ccaatccaga     19980
     cacacacatt gtttctttga cggtcacaga aaacggttac taccacagtg aagcaacaaa     20040
     ctccttaatg acagatgctc ccgagattat caatgatttg aaccacccag aaaagccaga     20100
     tactctgtat gggtacctat atgaagccct gttgttgcgt tacaagagag gtcttacccc     20160
     attcactatt atgtcatgtg acaacatgcc ccaaaatggt gtcacagtaa agaccatgct     20220
     tgttgcattt gccaagttaa agaaggatga gaaattcgcc gcctggattg aagacaaggt     20280
     tacttctcct aacagcatgg tggaccgtgt gaccccacgt tgtaccgata aagagcgtaa     20340
     atacgttgct gacacctggg gaatcaaaga tcaatgtccc gttgtcgcag aacctttcat     20400
     ccaatgggtt cttgaagaca acttctccga tggccgtcct ccatgggaac ttgttggtgt     20460
     tcaggtcgtc aaggatgtcg attcctacga attgatgaag ttgcgtctac ttaacggtgg     20520
     acattctgct atgggatatt tgggatactt ggcaggctac acctatatac atgaggttgt     20580
     caacgaccca actatcaaca agtatatccg tgttttgatg cgtgaggaag ttatcccatt     20640
     attgcctaaa gtgccaggtg ttgatttcga agagtacact gcatcagtgt tggaaagatt     20700
     ctccaatcca gcaattcagg acactgtcgc acgtatttgt ttgatgggct ctggtaagat     20760
     gcctaagtat gttttgccat caatttacga gcagttgcgt aaaccagatg gtaagtacaa     20820
     gttgttggca gtatgtgttg ctggctggtt ccgttacctg actggtgtag acatgaatgg     20880
     gaagccattc gaaatcgagg atcctatggc accaaccttg aaggcagccg cagttaaggg     20940
     cggtaaagat cctcacgaac tgcttaacat tgaggtgctt ttcagtcctg agattcgtga     21000
     caacaaagaa ttcgttgcac aattgaccca ctccctagaa acagtttacg ataaagggcc     21060
     aattgccgct attaaggaaa ttttagacca agtgtgattt taaaggtgaa ctgatctacg     21120
     cgccctcgat agtaatgact aaatatcttg ggtagagtat atataatgtc gtatttttgt     21180
     atattgtttt atttagacaa atagtaacgt gttatgttcc ttcaatcgca tctttcatga     21240
     tctttaatcg atcgtcaaat ggatccattt agagtttctc atcaccatcc ccatatcatt     21300
     tcactccacc ccgctttacg taaaaaaaaa aaaaaaaatt gaataaatga ctaagaatta     21360
     gacacaattt tgtcttaatg aatgcttttt acttatgaca catgccagtt tgtacatatg     21420
     ttgatcttca tagctccgat aatcttcata aattcgtgac aaattaaaat tacacattat     21480
     tatgtaaact ataatataca atgttgccta tcaagacaaa catatgcact ctatgatcaa     21540
     tcagaattct ttgagaactt caaaaatttc ttccaatcct tcttctcggt cttactttct     21600
     tcggaagaaa tacctctcct agaaggtggg acccaagatg cagatttcca tggttttata     21660
     ccttcttcgt atagtaattg gatttcctcc aaagatagac caatcgtttc tggtaaaaag     21720
     aagaaaacgt acaaaaacat agcaaccaaa caacctacga acacataacc ataatagaag     21780
     tggatagacc cagtaatgaa tggtgtgaaa aaaccgatca aaaattgcca taaccagttg     21840
     catgcagttg aaatcgacat ggctctagac ttgaccttcg aagggaacga ctcggcaacc     21900
     acaatataag caacaggagc ccatgtcgtt gcaaagcaga atatatagaa acaagtgaac     21960
     acaatcatgg cattacctgc acctttcgaa gaaggaccgt cctggccatg agggtaaaga     22020
     catttcaccc cgatacttgc aaatatgacc atacaagcca tcatcccagc tgcaccaaat     22080
     aacagacatt tacgacggcc aattttgtct acgaccataa cagcaataat agtggagaag     22140
     aagttcactg tacctaggac gatcgacgtc tcaaacccat cagtaagacc gactgattta     22200
     aaaatggtag ttccgtagaa gaagaagtag ttttcaccag taagttgcaa aaaggtttgc     22260
     acaagaatac ctgtgatcaa acgttgaagg actttagttt ttacagagaa aagttctttc     22320
     catgaagctt ctcctagttc cctttgggca aggacaccgg cgttgatttc atcagcctgt     22380
     ttgagtaccc atggatcctc tggtgaaacc ttgttgattt tggcaatgga agcacgggcc     22440
     tcttcgtgtc tctcacattc aatcagatat cttggggact ctggaaccaa taacatacca     22500
     atgatgataa tcaaagccca taaaaagcaa agcccaaggg ggactctcca ttgtgcagtg     22560
     ttatcgtatt ttctcgtacc ataaacgcta caataaccca agaaaatacc gaacgtcatg     22620
     ttcagttggt acaatgagac cagtccacct ctcaaatctg tgggggctat ttcagacaaa     22680
     agcattggac acaacaccga acagccacca gcaccaagac cgtagatgat cttaccgaca     22740
     aagtactggt accatttgtg atttgaactg atctgaataa ttgcaccaac catatatacc     22800
     aacaccacga tcacaattgc cagccttcta cctaaagtat cagcaagacg ggcaaaaata     22860
     aggccaccta tggcacatcc aatactgaac atagccacaa gaagacccat acgcacgttg     22920
     ctcaaataat attcaccagt gctatgcttg taagaaccga agttcatttt aaagttgtcc     22980
     atgttaatga aacctgctgt gataccacta tcccaaccag gcaggaaacc cccaaaggat     23040
     attggataac acagtaagta aatgacaaga taacctatga gccctctttt tggtggctca     23100
     acgttatccc cgtttatgac ttcgttgtca tcaaatccat ctgaccactc tttttccacg     23160
     ggtggtgcga catgaatatc agcatctcga acatctccat cgctatcaat agaggattgc     23220
     gcactagaca tttttttttt ttggtttaac ttttgtttct tttttctttt tttgattgtt     23280
     atgccttacg tgcaaagtag gaatagaaat tttacctcaa acaactctgt ttcatctgcc     23340
     tcttttatat gactttttag ttgcaattac ttgctggaag atacgacctc acacccttga     23400
     acgataaatt tcgacaaaca ctatgttcat ttgcgcatat atccagggga atcaacccta     23460
     gagagtactg tcttttcatt gggttctgaa tatccgtaaa ccaggagtta aaggatatta     23520
     ttatctaata ttatcctcga atatctacgt catgccgggc tagggcggat tcaacctcac     23580
     catcttgcct acctacaacc caccgcacaa gaaagcatcc cacgccgcgt ggtgcctttg     23640
     ttccttggtt cctgaactga tgattatact ttccccacgc acatgaaacg cataccccac     23700
     ccccacattt ctcatttaat attttttagt tttaactccg gtgcgcgccc cttgaagtta     23760
     aattaaacta actgtctgca tagttcaata aacgatgtcg acaacgatta ggtgattggc     23820
     tagccatcgc aacaagcaga catcaactga aactctaaaa tgtagtccta cagacaaaaa     23880
     aaaattgttg ttttcaggct tatgttcaag gaaaggaaca cgacaaatga ttgtcaatag     23940
     tatgtttctc tgaaggcaca ggttactttt tattgaatgt atttcaaact gcctttagta     24000
     aggaaggtgc ttttgcaaca ctttgcccct tcgttgtgaa gcatttggca gtacagcgat     24060
     aaatcctaga cattattaaa ttggtaaaag ggtgccatag aaggacacga caaccagagc     24120
     tcgtaccatt actattttgt tccattctaa aattatagaa ttcgcgttaa aatgtccggg     24180
     tttctcagca cttcagatta tagacatttt gtgaaatagc aaattgcagc acgatcggtg     24240
     attagcaata acggtgtccg agtcctttcc ctctcatgtt tttttttcaa ctacagtaat     24300
     tctcagcagc tgcagccttg aaaactatag gtcaatgata atatgtatta ataaccaact     24360
     cttggcgctt acaaaattga tttatttagt caattgaccc acatggaagg gtaaaaccgc     24420
     atacaaaaat ttctcttaca aaggatctta tgaacatatc aaatcaatta tagaagccgg     24480
     aaagactgtc atcctatata gggtggcaat gttattatca ggaagggtaa atctcatttc     24540
     taaattgcgg aaggagcttt gctctggttg aaattattat cattatcgct acttcagcga     24600
     tttcaatttt gcttactaga taccagcgtc aaggtcctat cttttgttgt gttgctgcct     24660
     caaacatgtc agtttaagtt tgaaggttga cactgtaaaa tttactttgt atattgcatt     24720
     tatggatgat ttacagtgtt tcaattatgc tctattgagg atagtgcttt tgcagaatat     24780
     ttcacttgag gccacgcata ctggcctaag gcattacatt ttgaaataat cttcgcatgg     24840
     ggcttgtcac agtcatgaaa ggggaaatag cttctagtat ctggcatgat atgtccttac     24900
     agaacttgat ctttcacagc ataagaatta ttacatccta atatagattt ccgacactgc     24960
     agtgaggcag atgccaatat tgaatcgaag ttttgattaa ggtatgtgag agtgtgattg     25020
     tttgacatcc ctccagttgt tcgaagatat caacggcgca ggaaagccgc tgataaaatg     25080
     gtcgctccgt ggttgaaatt gtagtaaata accacttttt cttacgtaga actttatcct     25140
     tttggctgtg gtttgaaatt attcgttttc ttcccaaacg ttgcagggaa ataagaaaaa     25200
     agaaggagaa ataatacctg acaacgtagc agcgagcctt agttcatctg ctcaggttga     25260
     aaaacattga tcttgagcat tttcatcttg cgctttaaat ctcttggagt ataattaaga     25320
     gcaaattgta acagtattat gacatttgca ggactcacac ccagaagtcc tttccaccac     25380
     ttcagtactg taacttgaaa aaaaaaggga gagaattgat ctaattaaaa ttatatagtt     25440
     attcaaattg gaagtaaata aataaggact gccggcccat ttttcttttt tttctcttaa     25500
     ctgacctgat atttttgaaa cacttaacgc cgttttcttc aattaaatca gaagtgcaat     25560
     tagtggtgct atgttaacat atgtttgaga gcctactaaa tgttagagtg gacagttctt     25620
     gcttacaatg attaagaatt gatggctagt aatgtgggcg gtcgcatctc gcttgtctaa     25680
     ggatggagtt cctaaattct tcacgatcgg gaacaggtcc tttgtcccaa cttgccagtt     25740
     tatcgtcaac gagtttatca atctcgtcgt agtggatagt aatccatgga tgatcttcat     25800
     taccgcaagt agtccaattc actggtggta gttttacgct ccaaaatctc ttatcataat     25860
     ccgctatgcg gtaaaatgtc gatgtattat gcgtaaaatt gttataattg tctgttgtat     25920
     ccgtacagca taccaatgcc aagccttgaa aggcgacggc tagtgccaaa attttcatcc     25980
     tttcagtata cctgattttg gctttatcct ttcaatgtgc ctgattttgg ctttctcgta     26040
     tctttcgcct gataatatga aaaagtatat actgtgaaaa aacaaccgtt ggagagctac     26100
     gaccgactga aaagataaaa atgcttgagt ttttcaggtt agcatgccgt ctagtagaat     26160
     taaaccattg tagttcttca cttttgtatt aaacgtagga ttgaggcggt ggctgctttt     26220
     ggtttactat gcgttgtaag gggatgggga aatggaacgt ccagaagaaa gttatagttc     26280
     ccgtttgcat aacagcagag acaaaaatgg tcgagcactt ccgtgttgac tgtatatctg     26340
     tgcatggttg actaattgtt gtttgatggc ctgaagttct tgtcacactc tgcaaattat     26400
     cccgacattc agacgtacac gtacaaaaca cgaatgctac tctagcatat ccaatcgatc     26460
     gcactgaagc gatcagctga tgatcaggcg gtacattgca tactctgcgt aaggcctttt     26520
     tcaccaattg accgcatcgt atatttccca atccggttat taaatcgtta tcaggcggaa     26580
     accttcgcga acagtatact ggagagtgtt gcgacaagat atttaaaagc ggaaaacggg     26640
     catataaaat agatgagtgc agactaatga aaaagacccc agacccatct ccaccttttg     26700
     caagcacgaa gaacgtaggc atgtcaaacg aagaaccgga aaaaatggtt aacgatcgaa     26760
     ttgtggtgaa ggccatcgag ccaaaagatg aggaagcctg gaacaaactg tggaaggagt     26820
     atcagggttt ccaaaaaacg gttatgcctc cggaagtagc caccactacc ttcgcaaggt     26880
     ttatagaccc tacggtcaaa ctatggggtg ctctagcctt tgacaccgag accggcgatg     26940
     caattggctt tgcacactac ctgaaccatt tgacgtcgtg gcatgtcgaa gaagttgtct     27000
     acatgaatga cttatatgtc actgaacgcg caagagtcaa aggcgtaggt agaaagctca     27060
     tagaatttgt atacagccgt gccgatgagc tcggtacgcc tgcagtgtac tgggttacag     27120
     accattacaa tcaccgcgca cagttgctgt acaccaaagt ggcttacaag acagataagg     27180
     ttctttacaa gagaaacgga tactgaaacc gctgtgtaat gtagactact gtgtatagag     27240
     ataactctag cttctatagg ctcacttgcg aagctttttt cccacttttt cccagtgaaa     27300
     tagtttctta ttggcttttc atagtttgtt ctccgattta atcgcaagcg ccgtacggcg     27360
     caggcacaga atgacttgca gcttaatcca ggtgcatttt aagaaactta tctgctggga     27420
     agaccccgaa gttcatcgtt tacaatgtgc cgtaaagaac acatttgagg gtgcaatctg     27480
     gttcgtcttt tgccataatt agtagtgctc atccgtgatc ctttaattta cttttgtgat     27540
     gcgatgattt gcagatacta tataagcaat ggacaccgtc catcaccgat gaggctagaa     27600
     catcgtagtg ctttgtaaaa gaactgttaa agacccagta cgaaaatttt tccataatgg     27660
     accctggtat tgctaatcat accctccccg aggaatttga agaggttgtc gttcccgaga     27720
     tgctggaaaa ggaagtagga gccaaggtcg atgtcaagcc aacgctaacc acatcttctc     27780
     cagcaccttc ttacattgaa ttgatagatc caggtgtgca taacatcgag atttacgcag     27840
     aaatgtacaa ccgcccgatc taccgtgtcg cattattctt ctcacttttc ctcattgcct     27900
     atgcttacgg attagatggt aatatccgtt acactttcca ggcgtacgcg acttcgtcgt     27960
     actcccagca ctcgctgcta tcgaccgtca actgtattaa gacggttatt gcggctgtag     28020
     gccagatctt ctttgccaga ttatcagata tcttcggcag attttccatt atgattgtca     28080
     gtatcatttt ttatagcatg gggaccatca ttgagtcgca agcggtgaat attacaagat     28140
     ttgcagttgg tggttgtttt taccaattgg gtcttaccgg tattattcta attttggaag     28200
     ttattgcttc tgacttttcc aacttgaact ggaggttgtt agccttattc attccagctt     28260
     taccatttat catcaacacc tggattagcg ggaacgtaac aagtgccata gatgctaatt     28320
     ggaaatgggg tattggtatg tgggctttta tactgccgct agcttgtatt ccgcttggaa     28380
     tttgtatgtt gcacatgagg tatttagcaa gaaagcatgc taaagataga ttgaagcccg     28440
     agttcgaagc gctaaacaaa ttgaagtgga agtccttttg tatagacatc gcattttgga     28500
     aattggatat cattggaatg ttattaatta ctgtattttt cgggtgtgta ttggttccat     28560
     tcaccttagc gggtggtttg aaagaggaat ggaaaactgc gcatattatt gtccctgaag     28620
     tcattggttg ggttgtagtg ttaccactgt acatgctatg ggaaataaag tactcgagac     28680
     atccattgac accttgggac ttgattcaag atagaggtat ctttttcgct ctactcatcg     28740
     cattctttat caattttaac tggtatatgc aaggtgatta catgtatact gtactagtcg     28800
     ttgcagttca tgaatccata aagtccgcta caagaattac ctccttgtat tcatttgttt     28860
     ctgttatcgt tggtacaatc ctcgggttca tactgattaa agttagaagg actaagcctt     28920
     ttattatatt tggcatttct tgttggatcg tctcatttgg tttgctggtc cattaccgtg     28980
     gtgactccgg tgctcattcc ggtatcattg gctctttgtg tctattaggt ttcggtgcag     29040
     gttcatttac ctatgtgact caagcttcca tccaagcatc cgctaaaact catgcaagaa     29100
     tggcggtagt aacctcatta taccttgcca cttataatat tggttctgca tttggtagtt     29160
     ctgttagcgg agctgtctgg actaatatcc tacccaaaga aatttcaaaa agaatttccg     29220
     atccaacctt agctgcacaa gcgtacggtt ctccatttac attcattaca acttatacct     29280
     ggggaacacc agaaagaata gctttagtca tgtcttaccg ctatgttcaa aagattttat     29340
     gtatcatagg tttggtattc tgctttcctt tgttaggttg cgcattcatg ttgagaaatc     29400
     ataaactaac agattctatt gctcttgaag gcaatgatca tttggaaagt aaaaacacct     29460
     ttgaaattga ggaaaaggaa gaaagttttt tgaaaaataa attctttacg cactttacaa     29520
     gcagtaaaga taggaaagat taatattatc tcacccaaat aatttcatac atgcacatat     29580
     agctactaca tagtcaagaa catatcataa catttggtat aacagtcttt atatcagtct     29640
     ttgcatggct ttgcatctga tgctggctct accgacttct cggcgataaa ataccaaaag     29700
     aatttgacgt atatactatc caaagtggat aaatatttga gttccaatga ggtaactaaa     29760
     ctagtttttt aaaacccagc agaaagaaaa aataccctat atttggcagt gctgtccatc     29820
     agaaccatta actgcatcaa taatagtttg ggtgctgctg attatcataa tcatgaaacc     29880
     aaagcatata caaagataga aaggaagcct ttccttccaa ctcttcttct tactagttaa     29940
     caacaaattt gtgtatggcg gcaaaatgta agccatagtc gatgccgtag tggccccaat     30000
     cagttcaaat aatgctccta aattacatgt agttaatgat atacccatgg tgatgaagac     30060
     tagtgaagaa gttataacga cgtgctgttt acctgataat tgagtgtgtt cgtcataatt     30120
     tttaataagg ttgcattcat gtaacaagtt accgacaaca tctctcaaaa caaaaatttc     30180
     catggggaat gtggttagca tgttaaatcc gaaacagagt ctggctatgt tgatagcagt     30240
     gtctgttcct gggaaactgt ttaaaacatt gccttttgtt ttttctttga aaactgcaaa     30300
     tcccgaatat cccattagtg cacagcatat tactgagata atgatactga tatgcgttaa     30360
     cctggtaaat tttgccacac ttctattcct catggaaaag aaaataaaac tagtattatg     30420
     atgacaaacc aacgcaaagg aaatgacaga gagacttctg aatatagtag ctttcatgaa     30480
     aaaatcagat aacttcagag aatgaccttt ccaatcatag ggcagcatag gtcctctaat     30540
     taccactgtc agtacaatta taatcatact tataacggcc aagaaagatg cctttgatag     30600
     tgcctctatg tttctcttca ttgataacgg aaaggaaatg aaagtagtga ccattacaat     30660
     tatgacattt cgcctgagcc aaaaatgtac attaccatcg ttctggctga atatagctct     30720
     gagtacgtgg ggtatcgtat ccccaataat tatgcaataa ccaatacatc caccaaatgc     30780
     aaataacccg tttgtaaata gaatcagcaa tttccctttt ttacccatta catgttcgac     30840
     cgtaccctgg tatgttctct tgccagcaag agtcaagtta atgacaataa gtcttaacgt     30900
     ccaatcaact ataaatccga gggctacgta tgataatagc ccgcctaata taccagcatt     30960
     tttgatcgcg aacggctgag taattattcc ggcaccaaga atagagtttg ctagattcat     31020
     aaaagccatt ctcatactag actttttatc gttttctcga agtacatcat taaccagagt     31080
     atcatccatg tcaggagtaa tgatattcaa agagttctgc ccttggcttc cgtcatcgga     31140
     gtcgttatca gttgtgcctg gaaaaggaaa atttgtcaat tcaaactccg ttctaagctc     31200
     tttgttttct aatttagaat actcacctaa ctcagacatt atcggaacat gtatatctgt     31260
     tagattctgg tcgagatatt ctttaatggt ttagtgtatg ttgcgcttac tactttttgg     31320
     cgtttttgcc tatttcacta tttacatatc gtgaaaatga catttggttc taggttcggg     31380
     tgacgtgaag ataacgaaaa atgagtaaaa attatcttct aattatacat tagtattagc     31440
     gtgaaaatgt acacatatac atatatatat atatatatat atacttgaag gtctgaagga     31500
     gtttcaaatg cttctactcc gtctgctttc ttttcgggag caagattgtt gtggtgaatc     31560
     atcgataaaa ataaatatac tgagattata gtaagctcat tgatccctta aactttcttt     31620
     tcggtgtatg acttatgagg gtgagaatgc gaaatggcgt ggaaatgtga tcaaaggtaa     31680
     taaaacgtca tatctatgct acaacattcc aaaatttgtc ccaaaaagtc tttggttcat     31740
     gatcttccca tacaattgcc tcaatgtctc ttctatcgga atcgatgtcg acatctccaa     31800
     tcttccaaat aaatctgcat ctgaatatgc attgaaataa gatccaaaca gctaagaaca     31860
     ggaaaataga gatataggcg gcagcaaagc taacaccatt gaattttggt gcaaaagccg     31920
     tgaaaccttg aataatgata atgatcgtca taaatgtggc cgcataataa gccaagccgg     31980
     gcattaattt agctttaaat ggtaactcgt cacgagagat gccacggtat ttcaaagctt     32040
     gcataaatct gatgtgcgag attgagataa ataaccatgc aaaaaagcct gcaacaccag     32100
     tgatatttaa tagccattcg aaaactttgt caccaccagt agatgtctcc atgtaagcca     32160
     aagcgccaaa tgcagcagta acgaaaactg caatgtatgg aacaccacct ttggtggtcc     32220
     ttgacaggaa tttaggagcc aacttgttct ttgatagacc aaataaaata cgggaaccaa     32280
     cgtaaatatt tgaatttgcg gcagaaataa tggttgttaa gataacagcg ttgaagatat     32340
     gtggcaaaac ctttgtacca gagttctcaa tagcaataat aaagggagaa gtagaaacgt     32400
     aggaagtaga ttgtgttagt ttagggtcat tgtatggaac taaaagtcca atgaataata     32460
     gagagccaat gtagaaggtt aagatacgga aaacaacttt tttgatggct cttggaacgg     32520
     attttctggg gtttgcagct tcaccagcag tgataccaac tagttcagta ccttgaaatg     32580
     tgaaggcagc gttaatcaaa gaggaaaccc aacctaagaa cctcccttcg tttttatcct     32640
     tagatattat acctggaccc caggcacctg ggtttctcca ataacggaat ccaactgggc     32700
     cggtaacccc agcaccacaa accatacaaa aacagtatat tagaaacccg ataatggcta     32760
     aaactttgat ggaagcgacc cagaactcga attcaccgta atatttgaca gggaacaagt     32820
     tcattattgt gataattacc caaaaaatac taatccatgc cgccagtgga actttgtacg     32880
     tccaaaattg aatgacttgg ccaactacac taagttccag ggcaaaagtg attgcccaag     32940
     aaaaccaata catgtaacca ttggccgcac caaatgctgg agaaaggaat ctttgtgaga     33000
     aaactgtgaa agaggatgta acagggatga atgtagccat ttcacccaag gactgcgtga     33060
     cagaatatgc caaagaaccc ataaataaat atgatataag agcgcccact gggccggcgt     33120
     tggtcagagg tgtggataaa ccaatgaaaa gacctgtacc aatagtacca ccaagggcaa     33180
     tcataccaat atgtctttgc ttaagctctc tcttcacttc agcgttctgt acttctcctt     33240
     catcttcatc acctatgcca tcctccatag agaacgtatc ctcgccattt actctcgtcg     33300
     ggaaagagcg caatggatac aattctttac ttttctcatc tttcaatggt attgacccac     33360
     gtctgtggtg tgtttgtgaa gcttcaacgt cgtgaaagag ggttgtgacc ggctcattgt     33420
     acatatgctt ctcctctatg tcggcgtctt cttttgaatt tgtcattgct atgccttttt     33480
     ttttttttgt ttttacagga gttaagaagt ctgaagaact ctgaaataaa ctttcgattg     33540
     acgacagatt aaaaactgga tccaactata agtataatag taacttatat atttctgttc     33600
     cagatatata cgtaaaaaaa agaaaaggat aattgatgtt tttgcaaaaa gggattccct     33660
     gattcggttt actctgttcg caaccactct tctttctgct aatttgtgct ttatctcgta     33720
     tcattctctt atctacttat cttaacctta tcgtcttcct cgaaattttc attgatagag     33780
     acaactgcaa aaaaagaaat tcaaaaaagc cgtatgactc acccggaaac cacacagaaa     33840
     ccctagattt ctatagggca aatttcaggg ttatactaaa agatatatta ttgaccttgg     33900
     ttattcttca agttcgccct attgaaaatt cggacacttt agggtttgga atctgttaaa     33960
     gatataagta aatatgatga taaagaaata ggtttaattt atacgcactt gccagtaagt     34020
     gattgatatt gcagaagtaa catgaatacg gttctgtggc ctttgctgtt tgccgttatt     34080
     ttatttcttt tttttgtttt ttttcttttt ttcagcacta tcaaggctaa taagggacaa     34140
     gagttcttac tcagtgtgaa cgtgttctaa ataagttctt gttctaatta attgtaacta     34200
     tttttatgca tttcttgtaa gaggaactgg agtaatcgta tctcggaaat acatagaggt     34260
     gcgtattcat aatgggccct ctatcacttg ttgcctgtat ctccgaatag gactgataag     34320
     tgataaaaaa aaagaaaact gggttagctt gaagcgactt tctttctcta ctaaagggaa     34380
     tggtcagatc atcaggccaa cggcaaatgc taagctattt ccaagggttt gtgcccatac     34440
     acacaatatt ttactccgtg ttccatccta cagaaggttc taagattaaa tacgagtttc     34500
     cgccaaataa tttgaaaaat catggtatta atttcaacac atttaaaaac tacatcatac     34560
     cgaagcctat attatgccac aagttgatca cttttaagta tggtacatat aggattgtat     34620
     gttatcctgt gacaatcaat tctccaatat atgctaggaa tttttttagt tttaattttg     34680
     tatttgtatt cccatatgat tgtgagacgt ctccctacga accagctatt actaggctgg     34740
     gcaaaatgtt caaagttctt gaagaacaaa atcaattgct atccaaatcg gaaagagatc     34800
     cagttttctt cgatttgaag gtgttggaaa actccacaac aacaccctcc actgcaggtc     34860
     cttcatccac gccaaatcct agtagtaaca ccacaccaac tcatcctaca tccgaaaagg     34920
     atacaaagga tatgagaagc agcagataca gtgaccttat caaggatttg ggccttccgc     34980
     aatccgcatt ttccatacaa gatttattga tgagaatttt ccaagacctg aataactatt     35040
     ccgaatgcct cataccaatt gatgagggaa atgcagtaga cataaagatt tttccgctgt     35100
     tgagaccacc gacaacttgt gtctcattag aagatgtgcc cctgtcgtct gtaaatttga     35160
     agaagattat tgatgtcaac tgggatccaa ccatgatgag tatagtccct tacattgatg     35220
     gcttaaacag cattgccaaa atttctaaac taagcaacag tgatcctggc ctagtgatag     35280
     agtgcatacg tcacttaata tactataagt gtgttacatt atcagatatt ttccaatttt     35340
     ctaacatata cgctccttct tcattaatta ggaatttttt gactgatcca ctaatggcta     35400
     gtgactgtca atcttatgtt acgttcccag aagtgtctaa aatatcgaac ttgcccttaa     35460
     acaaaagtct gggttcaggt gaccaagact caccatcatt ttctgtacga agaaaatcca     35520
     aatcatctag cataccgtca aacccggatt ctagaactac atcttttagt tctaccagta     35580
     gagtttctca aaactcctcc ttaaattcct ctttttcatc aatttataaa gactggaggc     35640
     aatcacaaac ctcctgctcg agttcaaata ttcatgtcat caacaatcgt aaccgattcc     35700
     taccaacaag atcatgccta tttgaccttt ataggtcact ttcacaaggt caaacgctga     35760
     aaacatggta tgagtcgaaa tatatgattt taaaagaaaa taacattgat ataagaaggt     35820
     tcataacgtt tggcctggaa aaacgtatca tttacaggtg ctactctttt cctgtaatga     35880
     taaatgcagg ttcacgtgaa ccaaaagaaa tgacaccaat aataacaaaa gatttagtga     35940
     ataatgataa gttacttgaa aaaagaaatc acaatcattt gctttcagcc acagggtcta     36000
     gaaatacggc acaatccggc aacttgaaac cagaaagacc atcaaaggtt tcatttgaaa     36060
     tgcaaagggt aagttcgttg gcaacaggca aaagtactat gccgaaactc agcgacgaag     36120
     aagaaggtat tcttgaagag tctattagga atgccgaaac atttgataaa atttgcgttt     36180
     tactgagcaa gcctaaatta gaagtcgaaa gctacctaaa cgaattagga gaatttaagg     36240
     taattaatag ctgagttaaa attagagaaa ttcattgtcc atcaaaatgt tttttttttt     36300
     ttttaatatt acaacttatt tccgtaaata aagatagtac acacgaatcc aaacgtttat     36360
     atagttagct ctgtgaaaat ttgatttagg ttcatctctt ggtgtgtttg gtagaggtgg     36420
     tttcacaccc ttctcttctg tcttgccttc taatgaataa ctgagtattc tttacatact     36480
     ttgtttttat taaccactag tttgaatata tattcgactg aaaggcaata tcaactattc     36540
     aatctttaac atttttctcg agccctcatt gtccacattt tcactggatt tgttttcatc     36600
     ttcaattgca tgctttttgg gcgatattac actttgcact gaattgctat ttatgtttga     36660
     taaccttaac ggcattttct tacttagatt tggtatttcc ttcaatatgt tctcgatcat     36720
     ttcgtctttg gtagcgtttt ccttgttacc atagtttttc attatgtttt caatcgtatt     36780
     atagatatca tccacattag ttatatgaga gtgtgttgat gttatcgaat ttttaatgtt     36840
     atctttcaac atgttatgct tgttaataag ctgctcaaat tgatcattaa atttggtatt     36900
     gttcttcaaa agggatatag cgttctccga ttcttccact tgtcctttca tgactgaaat     36960
     agactcattc atcgaatttg atgatgtatc aacagtactc ttgatttgcg atagcgtcgc     37020
     tgccatgcta ttatagaatt cgttattcat ggagtcacaa tcatttatca gatcaaatga     37080
     attttcccat ttaacgcgct tgggttcaaa cagatccatt tcttgatcaa taaccgcgct     37140
     ggttgcagtt gtcagattct gcattattag ttttttattt tcgtcaaggt ggtcatttag     37200
     gaccttttta aagttctcaa caaactcgtt tgttctcttc tcaatatttt cataagtaga     37260
     atccacatga cgattcagta attcttgatg gttattcttg aaaaaatggt tttttaagta     37320
     ctgtttcatg ttgttatttt cttcgctaat atcagaaaga ttctcggcta tatttttata     37380
     aaatttttgg aaatctactc ttattatgtc gattttctca ataacaacat tgaagaattt     37440
     aggagattcg tttaaaattt tcttcacaca gtctttgtac attagttcag ctttttcttg     37500
     catggttctc ataagagtca gtacttcatt tttgatcata tcaagatttg gttggatatt     37560
     agtctcttga agaatacttt cctgttgcat agtgtttaat tgtaaaaaca gtgtagattt     37620
     caatttttta atttctttag taatatgcat ttcaaacttt tgattaaggt caagttctct     37680
     ttttttgtaa tcatgtaggg ccatttgcat tacctcagtc aacttctgta gtttgttatt     37740
     aaaatcggat atttcaattt cagttttatg ctgtttatct agttgtgccc ttaaatgatc     37800
     tatggtagtt ttcaatgatt ctatttggca attttgagat tgaatagttt cttttgactt     37860
     caatttatct tttactagca atgcattttt cgatgtcaaa ctttcaattt ctcttttaca     37920
     ttcttgaact tcatttttat aactttctaa atcactgttc aaatttttgt agtgatcttg     37980
     gctcatatat attccttctt tggactttgt agagagtaaa tcggatttaa tctttgctaa     38040
     ttccatagtt atatttttaa ccaaaatatc cttcattata aatgaaccca gttgcggctt     38100
     gttcttaatg tttttagcct tcgaagcata ctctaatgta ctgcaggttt cttcagaagt     38160
     tacctttgca ggcgatatag tagcaattag tgcggttttc gtattaccac ccagggaatc     38220
     ttgaagcagg cgggtcaatt tcgattcacg gaaaggtata tggccgcttt tatctacgag     38280
     tgcgtttatg accctgccca gcgtcaatag actttggttg attgaaccag cttctttggc     38340
     acgttgattt aatgctccgg atctgttgat gttttctgaa ccagctaaat ccacaagatt     38400
     cattttggaa attctaaata gttcatcctg atgcttctta tacaaagtga ttgtaaaaat     38460
     ggtatgagat ctactggaaa aatcgttcat tttagtggac gctacttgcc tatgctttaa     38520
     gcctttttgt aataggttta gcccctccat agcatttgtt atgtgaaatt cttgcaaatt     38580
     ctggatgtat ataccattag tttggtcatt tggagccatc gaacttcttt gaccgttatt     38640
     tgtgttggtg ttactagaag cattattagt ggtagagcca gagttagagg aagagttgtt     38700
     cctggaattc actgcctgtt gttgttgata ctgttgcttg atggtattcg gcagtgattt     38760
     tgtccttaac ctttttctta atagagcagc tttaggtgtt agatcattta atgacctcgg     38820
     agaactgttc ctagaattac tcctggaact actagcactg ttgctagtgg tattatttgc     38880
     tgtgcttgaa tcaaaaatcc tcaatttttt cataaattgg ccgtcaaagc cagtattact     38940
     agagccgttg ctattgctgt ccaagaggtc cttcaattct tcgttgtaga gttcaatgaa     39000
     cgaacatttt actacgtaat cgttctgttg tagttccaat gtgtcaaaca acttcaaaag     39060
     aaccctcggt ataattcctg ctgcatcgct caattcacca ttatataact tttcgtcgcc     39120
     cgtcattgta tatgttttac ctgttgacgt cataccatat accagtacgg tgcaattgta     39180
     acctttaatg aaatcctgga ataatgggcc cgccacttca tcaaaaatta gatcctggga     39240
     agcgccggga ccgaagactt tgtccactgt gtatctcttg gcattcattt gagcagttat     39300
     accggtatct cccgtcgtgt taatggaaat ttctttagaa cctgtaatat ctggaacatt     39360
     taccacaacg gagcttttca tactaatttc cctttcattc cttcctctgc atcgcacagc     39420
     tacagtgatg ttcagttcct cattaggaac agtgtgacat ccaacctgag agttgccatt     39480
     tttactgatg ctgttggagc ttctatcttg acccgtattt tggttttccg ctggcatcaa     39540
     acaaattctt tcttgttgta ttttttgcgc ttttatatac tttttattac tttttccttt     39600
     gaattgcttg cttctgtatc tatactcaac gttactttct ggccatacca taagttctac     39660
     acccgctgtt gagaagcggg tcacaaagga agtctttaga tgatgttatt gttgcggcct     39720
     tgtttgtttg ttttgtttat ttcgcgtacc taatacatcg tcaccacaca cgaaaacgaa     39780
     aacatttgat cagataagtg atctgcaaat aagatataat aaaagtaaca gttatttatt     39840
     taattaaaaa cgcaaatatg tagtaatacg tgggacatat aaatttcatg aattaaaaaa     39900
     aaaaaatgaa attcagattg aaaataatgg ggatataaaa aaagtggaca aacgatagtg     39960
     aagagggact ccgacttgta acctcgagac gcctaaggaa agaaaaagaa aaaaaaaagc     40020
     agctgaaatt tttctaaatg aagaattaaa taatattcaa tttatcaaga atatctctca     40080
     cttgatcaaa gattaaatcg gtctttgatc caatgaattc atccatgttc aattcttgct     40140
     tgaaaccaga tgaatgggac tttttggtat cattccagaa agcggacaaa tcttgaccac     40200
     caccgttgta gattaaaaca tttggagtgt cttcagggat atcgaacaaa atgtcctttg     40260
     tactgtaatg aattagcttc tttttcaatt gctgaggagt caaagaatcc tggcccaatt     40320
     cgaaaaattc actatcagaa cctggttgca aagacaaaaa gtaggtcaac aaaccagcaa     40380
     cgtgagggga agccattgag gtacccgata aagtggcggt ggcgtcatca cttccaatgt     40440
     aggtggacaa aatgtttaaa cctggggcga aaacgtcgac acacttaccc cagttggaaa     40500
     agtaggctct gtcatcgctc aacgtggaag ctccgacggt gatggccttg tcagcagaag     40560
     ctggggaggt attacaagcg tcttggtttt cgttaccagc agccacggca aagtgaatac     40620
     cgacttcaac ggctgcatta acagccaagt ccaaagctgg ggacttgcca ccaccaagcg     40680
     acatattggc tgtggaacct ttgaacccct ttttcttttc ttgggcttct ttttggtgcg     40740
     cctttgcggc atattcgaca cctttgacga catcagacat ggtaccagac ccgtttgatc     40800
     tcaagacttt caccgcaaca acgttggcat ttttagcgac accgtagtgt ttggaagcga     40860
     tagtaccggc acagtgggta ccgtggccgt taccgtcgag atcttcgtcg ttaagtggga     40920
     tggttttccc ccaaatggct ctcttttcga agtccttgtg gttgatgttg acacccgtgt     40980
     caataacata ggacgtgaca ccgcgaccgg catcatcatc gtagagatac ttgttgaagg     41040
     accccaggtt gaggcgctct ctgtgggaaa tacgggccaa cccccatggg gcgctatttt     41100
     gagtgtcaaa ttctgtagcc tcgacaatag agtctctctc aacaaagtct actaatgggt     41160
     tttgacgtat caagtcgaca atctcttggg tgaagtaacc gatgtaaccg gagaaaagat     41220
     tatcgatgtt gaatgagtcc tggataccgc cagcctcaga ggtggacaag gaggtgtctt     41280
     tagtagaaat gaagaaagcg tcttcggcag ataagttctc tacggattga agttgtgcct     41340
     gctggacgtt ttccttgtgg aaatcgatct cttcttgagg ggcacctctc ttgaagacta     41400
     taatgtagcg gttggggatg atcttggaga tcgcgtctgg gttgaattgt gcagtggaca     41460
     cgagaggagc cagcctgttg tggtgcctcc ctttctccaa cgtcttttcg tggtgcttct     41520
     tgcccttgac tttcttacct ttcatcttct tctcctccac cttattttcg tggcagccac     41580
     ccttatggtg aggcttcttc ttcttatcat cattatcatc atcattggaa ctttcatgct     41640
     taggcttcat gccctttcct ccctcgtggg cgctcccatg agagccactt gcacgtttac     41700
     cgttgaattc cggagactcc ttgtcttggc ccttgcggcc cttcttatgg aactttccat     41760
     gttctttatc ttcagagtca gatggctcct catcatcgtc cttagtgaat tccacttttc     41820
     tgggtctctc gtggtgatct tccttgttaa tcagttcgtg gtggtcggcg gcattttcaa     41880
     gatttgggat gaccaaagca gcagagatgc tccctagggc accgagtgta aatagagtat     41940
     tttctaactt catctttgct tgttagaatt aggtttagtt tgttttttta ttggcgatga     42000
     agctaattgg actcttaagt ttgtatggga agaactccaa tataacggga cgtaacattg     42060
     gccccctttt atattcatcg cgctctttat cgcgggtgtg tttgcccccg ccactcccgc     42120
     agtcctggcg tgataagcca ctgcagtggc attactgagc ccaaattttg ctttttcaac     42180
     aagtcaccta aatttccaaa gccgaaagcc ctgctactct gctaacccgg agcgtttaaa     42240
     gtccacggac atttcccagc cctcgttttt tctcctcccg ggaccccggg cataagtgca     42300
     tagtaggcac agacctgatc tgtcgggtgc agtttaaaaa agtcttggca aaatttttta     42360
     tttatcacac tactgtgcta tatagagtat atgtaatttt taactattgg tatatgtgtc     42420
     cgtgacctcg tagttagtgg ctgatttgtc gggtgcaatg cagtgttcaa aaagcctctt     42480
     aaaaggcgag cagacgtatt cggctccttt gaattggcac tcccattgca caagctcttt     42540
     cagccggcag ttggtttgtg agtcaagcgt tgctaacggt gcgagcgctt ggtccctagt     42600
     gcggatggtg gttggaggcg ccatgagggt tgattgtctt atctgcgata gatgagtctt     42660
     tctttccttc tcttttcccc ttttctcccc ccctgtttct cgtccatctc tatctgtcta     42720
     tctgtcttat ctactgttag tttttttttc gctttcacga taccgcatta cgtactgcgc     42780
     tgcggaagtg tggatgagtg gcatatacac tcttctgcag aggattttcg tacacaacgg     42840
     tgtgtgtgtg ctgtgaagct gtctgcttcc ttacttggct gtttgcttgc ttgtgcgtca     42900
     tggtcacttt tgttagaagt gagccgcata aaatggcatg tcggcacagc ctacagttaa     42960
     aaattaagca tatctgactg tttatctgtt tatctgttta tacacggtga actgtcacga     43020
     gaacccttac ttgcacgatt agcagattgt tcagagagcc tcgctcgttg aagttcttct     43080
     atatgccagc gtgtttcatg tagcaggaaa cgttgctcta tttatatctt ttctgacatt     43140
     ttgcgtcgtc gggaaaaaaa agattaagta agaacaaaaa accgttaatg gtttcagcaa     43200
     tcgagacaag tacaaggacc aaggcaaagg tcagcagtaa gcttagagac gatgaaggtt     43260
     gattacgagc aattgtgcaa actctacgat gacacgtgcc gcacaaagaa tgtgcagttc     43320
     agttacggta cggccggatt cagaacgctg gccaagaatt tggatacggt gatgttcagt     43380
     actggtatac tggcggttct caggtcgctg aagcttcagg gtcagtatgt gggggtgatg     43440
     atcacggcgt cgcacaaccc ataccaggac aacggggtca agatcgtgga accagacgga     43500
     tcgatgcttt tggccacatg ggagccatat gccatgcagt tggccaatgc ggcctctttt     43560
     gccactaatt ttgaagaatt tcgtgttgag ttggccaagc tgattgaaca cgaaaagatt     43620
     gatttgaata caaccgtcgt gcctcacatc gtggttggga gagactctag ggaaagtagt     43680
     ccatacttgc tgcgctgctt gacttcctcc atggccagcg tcttccacgc gcaagttttg     43740
     gacctaggct gtgtcactac gcctcaattg cattacatta ctgatttgtc caacaggcgg     43800
     aaactggaag gagacacagc gccagttgcc acagaacagg actactattc gttctttata     43860
     ggagccttca acgagctctt cgccacgtat cagctggaga agaggctgtc tgtcccaaaa     43920
     ttgttcatag acacagccaa tggtatcggt ggtccacagt tgaaaaaact actggcctcc     43980
     gaagattggg acgtgccagc ggagcaagtt gaggtaatca acgacaggtc cgatgttcca     44040
     gaactgttga attttgaatg cggtgcggat tatgtgaaga ctaaccagag attacccaag     44100
     ggtctttctc catcctcgtt tgattcgcta tattgctcct ttgatggtga cgcagacagg     44160
     gttgtgttct actatgtcga ctcaggatca aaatttcatt tgttggatgg tgacaaaatt     44220
     tccactttgt ttgcaaagtt cttgtctaaa caactagaat tggcacacct agaacattct     44280
     ttgaagattg gtgttgtgca aactgcctat gcaaacggca gttccaccgc ttacataaaa     44340
     aatacgttgc actgtcccgt gtcttgcact aagacaggtg ttaaacactt gcatcatgaa     44400
     gctgccactc agtacgatat tggcatttat ttcgaagcaa atggacatgg tacgattata     44460
     ttcagcgaaa aatttcatcg aactatcaaa tctgaattat ccaagtccaa gttaaatggt     44520
     gatacgttag ctttgagaac tttgaagtgt ttctctgaat tgattaatca gaccgtggga     44580
     gatgctattt cagacatgct tgctgtcctt gctactttgg cgattttgaa aatgtcgcca     44640
     atggattggg atgaagagta tactgatttg cccaacaagc tggttaagtg catcgttcct     44700
     gataggtcaa ttttccaaac cacggaccag gaaagaaaat tgctcaatcc agtggggttg     44760
     caagacaaga tagatcttgt ggtagccaag tatcccatgg gaagaagctt tgtcagagcc     44820
     agtggtacgg aggatgcggt gagggtttat gcggaatgta aggactcctc taagttaggt     44880
     caattttgtg acgaagtggt ggagcacgtt aaggcatctg cttgaaagca ttattcgatg     44940
     tatagtatag ctatttagat atacagagag ataaatgaaa gagaaaaaat attggtatca     45000
     atcaacgttt gttacaggct tagactttgg tttggtaatt gaaattcatg gtagtggaaa     45060
     taaacaaaat tttcctcttc aatttttttc gtcgtttcgc tctgcaatcg aaaatcaaat     45120
     aatcttcata aaagaaatca ctttcaataa atgaacttct cactaccata atggatgatg     45180
     tggccgattc gaaagcaata cggttgatta acacggaaac cccgagtgat aagtcaccaa     45240
     aaaaaattct ctttacgatg aatgttccga atttgttctc ctctttacag ttttcgttgg     45300
     aaaggtattt atatgtaatt tccttcagaa ttctcttgtt ttctatgttg gcattgtcga     45360
     gatgaacctg tttcagtatg gcattgggaa aaagtgtagc ttgtaacttt aaaacttgat     45420
     catgcagtgt tgcagctaaa ttatccagag taaaaatttc ctctttggag taaatgccta     45480
     gcaagttttt cagctgacta ctccaacctc gcctggccct gtgctttcta cttacacaat     45540
     ctttgtgatt tggtggtaag gtttttggaa aatgaggaag agtatctagt tgttgggtaa     45600
     tgtttctttc caagaatgat atttttttca ttatgacgtc aatttcttta gaataagccg     45660
     agaactgtac agttttaaaa ccctttctgt tgtcattcct ctgaatccca tcatttgcca     45720
     tttaattttc aatttagtta ctagtcaatt ttctttttcg ccttttgtat tccataatat     45780
     gaatataagc ttgggcttgc cgattttctc cgcttaatat taagcctacg catgatgtag     45840
     gttacatttt gaagggtttc ttttaacttc cttacttatt tatatatgta tgaacctaca     45900
     caaggcattt tacccttatt tcttcccgca acatttgata aaaagtggaa gacgtttgtg     45960
     attgttatta tcgccccaat tttctccttt ttttcttttc cttcaacgtc aatcaattgc     46020
     acattcagcc gattggcttt cttagcgcag gatagggtgt cggggatacc tgtgggaagt     46080
     tagtgacact tttttttcca ctctcttcat ggaatccccg gacggcagcc gcccgtccca     46140
     attttggcaa aattgacatc ctaactgcac gaattctcat cgcgtatcag aactcttgag     46200
     ccttcagttt tactactcaa tgctctgatt tatctatata tacataaatg aaaataatac     46260
     gtgcgcattt ataagacaaa aagttagaat tctgaccacg attgcatgct gtagataatt     46320
     gtcgtgttca ttctctcttt aacggcgcct caagaagaat ataaaataat tgctcttgca     46380
     gtctcaatga gtcggtatgt tcaaagtggt gcccaacatt tactaatatt ggactgcggt     46440
     acaaaatcgg cggctaaact gtctaccgat aaaatactct tgatttataa gaatgaaaaa     46500
     gaaaacaaaa agggatgacc cctgaaaaag tttgttttct ttaccctttt ttatgttaaa     46560
     ttttacattt attaccgttt acgtcaatcg caatatacag gtggggcatt gttatttgat     46620
     ttcataatct ggtgagaacg ttatcacgcg gattatttag tttttttaaa ccatgtgcga     46680
     agaaattctc atatattgta ggcatttctg actcaaactt ctgctgctta aaatagctgt     46740
     tttcaccttt tttttcctct tgttctattt gacatgctcc ctttcttcct cggtcctttc     46800
     aaccatttcc atgctcctgt aggctcagga gcagagcgag gaaaaaactt ccctacagaa     46860
     agctttcatg tttttaaccg gtttcctttc agctttttct tttggagtaa tctagaaaga     46920
     ttaggtcatt tgttcagtct atttgatact tgatgagtag ctcgtctgtt ctgttcaaaa     46980
     taacaatttg tgaggtgtac ggatgttttc actggcattc gtcgacatga caaagacaaa     47040
     ccttgaaaat aataatggag aataactaga aagacgttac tatgcctcta atacttctgc     47100
     ctctcttatc tctcctatca attgtggtta gcctagtagt caccaaatag caaattacca     47160
     atcaactatg gaaaaccaag agaaaccgct ttctgtagac gaggagtacg atttatggaa     47220
     atccaatgtt ccattaatgt atgactttgt tagcgagaca cgtttaacat ggccatcttt     47280
     aaccgtccaa tggctcccta ctcctgttca agaattagat ggtggcttta ttaaacaaga     47340
     attaatcatc ggtacgcaca cttctggtga agaagaaaac tatttgaaat tcgcagaaat     47400
     taatctacca aaggaaattc ttagtaatga agacccacaa gaagaagcag gagaggagta     47460
     tcagtcctct ctacctgctc ctaggtcaaa tataaggatt accgctaaat atgagcacga     47520
     agaagaaatc actagagccc gatatatgcc tcaagaccct aatattgtcg ccacaataaa     47580
     tgggcaaggc acagttttcc tctattctcg ctcagaaggt cttcagtcaa cactaaaatt     47640
     tcataaggat aacggttatg ctttatcatt tagcactttg gtcaaagggc gattgctttc     47700
     cggctcagat gatcatacag tcgctctctg ggaagtgggg agtggcggtg accctacaaa     47760
     accagtacga acttggaatg atttacattc tgatattatt aatgataata aatggcacaa     47820
     cttcaataaa gatctattcg gcactgtttc agaagattct ctcttaaaaa taaatgacgt     47880
     cagggcaaac aatactacga tcgatactgt gaaatgcccg caacctttca acacattagc     47940
     atttagtcat cattcctcaa acctccttgc ggccgcaggt atggactcgt atgtttatct     48000
     atatgatcta agaaacatga aggaaccatt acaccatatg tcgggtcatg aagatgcagt     48060
     gaacaatttg gaattttcaa cccatgttga cggtgtagtt gtatccagcg ggtcagacaa     48120
     tagattgatg atgtgggatt tgaaacaaat tggagcagaa caaacacctg atgacgcgga     48180
     agacggcgtt cctgaattga tcatggtcca cgcaggtcac agaagttcag tgaatgattt     48240
     tgatttgaac cctcaaatac cttggttggt agcaagtgct gaagaagaaa atattttaca     48300
     agtttggaag tgttcccata gtctacccat cgtgggaggt ccaccaaagg tgaacaagga     48360
     tataataagc taatatatag tttttttatt gtttctttgg cgaaaaggcg taattaaaca     48420
     aagatcaaca tacataatcc gattttgagg agtgataaaa tatacttaga ttattcctta     48480
     tccattacag tttgcttttt tgaagatagc caattgatga aatcaataaa aatgttaggt     48540
     ccacattttc ctttttgcat ccactctttg gtagttgcag tatacaagtc aatcaattcg     48600
     tcaagcttgt cgttaccacc gatttcaacg tataacttac tcaaaaacag tgagctggtt     48660
     gagcacattg aataaaacac tgcagcatgc tgacctggct tagaagtcag catcagcttg     48720
     tgtgtttttt tcaacaaatc cataagctcg atgtctttgt tcatgtcttt gaatgcagtt     48780
     acttttatct tgaatatttt acccttcaac aatttagaaa ttttgtcggc aagtggccta     48840
     tcaagagttt cattgacaca tttcagcatt gggataataa aataaacgag cttgcttaat     48900
     gagcctccta aattgttgga atgttcactt ttattagcaa gagtcaattt ttcacaatat     48960
     ttgacgtaaa cggctaacat gtcgacaact ctatgcttga acgagataac gttttcccta     49020
     gattgtttta cctcaaattt cctctggttt ccagtagata tgcttgataa tgcttcctta     49080
     cgacgtttga aaatttcgga taactgatca tctaattcca tcattttttc atcatccata     49140
     gactcctcat cttcatcgtc tccaccgtcg tcagaaagcc cttcgagttg gtctaagtca     49200
     acttcccctt tatcattaac tatgttatcg ggtaaattta acgccttcac taaggcgcta     49260
     gtggcctctt tatcaatatt caaaatatct tcatttgcct cgtcttcttc atctttttca     49320
     tcagcatcat cgctatcact ctcactttca ctttcacttt cactaccagt tttcgattcg     49380
     tcttcactgg catcattttc ttccttaatt tcttcaaatt cttcttctcc ttcgaatagc     49440
     tgggcaaaac cttgcttgtt ttctctcgct tttaaaatat ctaataaaat ttgcaattct     49500
     tccaaaccaa cttcttcaat aaactgctgc cagattatta aactcaattt cctgagtaag     49560
     gccttctttt gggctaaaag tgatagtaag atttcagtga tgcctaccat tgagttattc     49620
     tcgtgtttgg aaaattcgca aagttcttcg atcacagaaa tagaatcggt gtcacctgca     49680
     tataattgta ctaagcacat agataacaac gtgcttagac cccaagattg agcagttctt     49740
     gatctgcaaa ctttactcaa gcaagatata gcttcgtttt ttatattttc taaattttcg     49800
     tccagtggat tgattaaatc tcctacatga gaattttcaa tgtccagtat taactttaat     49860
     gtcagatatt gccatgagtt tatttcagga tctttgcaac gtatttcttt gtttattgtc     49920
     aactctccca ggatggaata aagtctttcc ttggctaatt cgtgtagctg ttctaacttc     49980
     agatcatctg atgtatgttt gaagaaagcc atatatacga tgggtctcaa cacgggcttc     50040
     attatgtcca tgtcattgat ttcgactttg tgtgcacgaa ctatatgaag gatggaatca     50100
     agagcaaaaa gggtatgaga taaaactccc tttttatctt gtaactgtag aaaaaacaca     50160
     tcgagtaatt gggcaagaac agtagaaggt aattctttaa ttgcaataag tttggaaacg     50220
     gtgccagatt ttgttaactt atcaaagttt atggaaccgt gaggaccaaa taacattgca     50280
     tttaaacaag gtactagtct gtttgcagaa tcttcttcac aagccttcac tatggagtct     50340
     aaagttaact gggaaatctt atttaaaact ctttgtgaat ctattgattg gttgatcaat     50400
     gttctcataa cgttttggct gaagcaaaac ccgatgtacg agccaggaac tgccttgaaa     50460
     gccgcgtcga ttattagaaa gcctaaatat tttctttcac tagaagcttt ctcattgaaa     50520
     aatgattcgt ccacggccat tttccaaaac tctggaaatt gaattgaatt ctgaaccttt     50580
     ttattgttgg ttttcttcct tttcttcgaa atatgactag tgttctctaa ttttccatta     50640
     ccaaacaacg gtagcagaac actccaaaca aaatgcagcc tagggttcca attcgtgttt     50700
     ttttgttttt tcgtctcttt taaacctcca ttggcatccg gaattacaga agagtttctc     50760
     aatacttttg ttaaaagggg cagatttcct cttgccagag ggtcgttatc cttccaacct     50820
     ggatttttca aatccaacac cgagggaatt agactttcat caccttcata tttcagcaac     50880
     aaataagttg acagtccctc atttgtcaga gtcaggtcat atttatcata tatcagaaga     50940
     attttttcag cggaactttc atccataaaa ggtagcagca ttttcatagt ctggaaaagg     51000
     gtaaaaaagc atggttcttt gatccagttt ttcttcaggg ccagatcaat tagctgttcc     51060
     gtgaatcgaa tgaaaaactc ggtgtttcct ttttccaaat ctttaacaaa tatttctgag     51120
     aataaaggtt catttagtag agatttcaag ccaaataact tcccaaataa aattccacgc     51180
     tcatctttgc ccttcatgga tttttttgtt ccctcattga cattaacgtt caaaatggtt     51240
     gataaggtgc tcaagaactc gttcgttgat tctaaacctt ttggtcgttg acctggtggc     51300
     atattaacag ctaaattgat tacttccgtc aaacataaag aaaatcctaa cctcgcgcta     51360
     tttctgtcag acgacaaacc cttgattaaa cgattcaata cataagacca ttcttctgca     51420
     tcgtcgggca aatctaatgc ggataagtcc tttattaatg cgacagctgc atgtagacgc     51480
     tcttctcgaa gatcagaagc tagtttaaaa aaaaggtctc tgttgacttt ccctgtcatt     51540
     ttttttgtgg acaaaaagat gcacttgtgg aaagaatcac ccttgttaat ggatacccga     51600
     ttcaaacttc gaattaagtg caaaccgcag cctcagatta atgttaaatt gccctctaag     51660
     gcaattctgg ccatcgcaat aaaatttttc gtgttattca cgctttaaag gccgggtaaa     51720
     atgatagcgt ccgttgattt tgaagactat tacttttg