(data stored in SCRATCH zone)

SWISSPROT: C0H4R8_PLAF7

ID   C0H4R8_PLAF7            Unreviewed;      1457 AA.
AC   C0H4R8;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   11-DEC-2019, entry version 65.
DE   SubName: Full=Serine/threonine protein kinase, FIKK family {ECO:0000313|EMBL:CAX64094.1};
DE            EC=2.7.11.1 {ECO:0000313|EMBL:CAX64094.1};
GN   ORFNames=PF3D7_0805700 {ECO:0000313|EMBL:CAX64094.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64094.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAX64094.1; -; Genomic_DNA.
DR   RefSeq; XP_002808817.1; XM_002808771.1.
DR   PRIDE; C0H4R8; -.
DR   EnsemblProtists; CAX64094; CAX64094; PF3D7_0805700.
DR   GeneDB; PF3D7_0805700.1:pep; -.
DR   GeneID; 9221936; -.
DR   KEGG; pfa:PF3D7_0805700; -.
DR   EuPathDB; PlasmoDB:PF3D7_0805700; -.
DR   InParanoid; C0H4R8; -.
DR   OMA; NIHGNRN; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   4: Predicted;
DR   PRODOM; C0H4R8.
DR   SWISS-2DPAGE; C0H4R8.
KW   Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:CAX64094.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:CAX64094.1};
KW   Transferase {ECO:0000313|EMBL:CAX64094.1}.
FT   DOMAIN          1090..1453
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          63..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          372..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          670..807
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          33..53
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        63..116
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..155
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..414
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        683..806
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1457 AA;  171805 MW;  1D8ABC73EAF86FA8 CRC64;
     MIRTSEKVEY CKSKTMTCDD DYLSLKSSKT LNIDNGEEEY EKLGNERRDV QNMNDAEDVS
     LYKNKKYNPK KNVDKNNVDK NNIDKGNVDK SNVDKNNIDK GNVDKSNVDK SNVDKSNVDM
     CEGNNIKSTD RKSNNTKRNS SKYNGLEERD DEDNSNNNNN MNSMYDRNMV NTTYYENVQH
     MISKDDNESF DNYPKESKDL SEKFMNKNML DNNNNSNNNN NNNNNNNTIM NEEDIFMKYI
     EDTKNNDSSK NFVNDKEFVC TMSKDKYSEM NRSTTEIFDN MNCIEYTDEY KQTNNQNFNS
     TIMMKEDTNK DDIKNVYRNI SMDPKDCSGI NFNEMNVEED NNVVIGNNSN LESYENMGNE
     NYTENIMYRN KKEQDEDEGD NDEEDKNSNN NYNLNDHNNN TEEERKKNDT FYKKNGDYKN
     MLSNQDIYNE TENINDSTTE CTIVKDVPKC ITNNHIQGNL LDNTYLPKDV NANFRSYEQV
     DVKDNNSLLH TPIGCENKNK SYVNFPFNTV ENKNIHITME EEKYRDHNKV HHEIDDNGYI
     INSRDDAVNN KDSFYKSLSQ QIYIDKNGSK YNVDISNDLF KKKCNINDKN MKNNYNENND
     ILRGAGQNDM PNNMHNISQK GFHLNQEGIN DMLRNQNNIA FQNSQYNGYI KDEQNIMNNL
     CERIEPSYID STSKRDSEGT KSAVHKNNIN RNNNNYNGNI NKNNNNIHGN RNSNNIHGNR
     NSNNIHGNRN SNNIHSNRNS NNTHSNRNSN NTHSNRNSNN SNRNNYNSFV VPGNMNSNNN
     DNNDKSYNND KSYNNDNNYN NDNSYDKSLD EYFRNNLPED IIKNIKYENP SNTYNDLLNN
     RDYDLISKIK ENPVYYSSEK EKKRMKNKDM KQPKYVSNEK LDLDEHTHIY KNNNEDNNYN
     SMNRDTTIIS KCDNPEMHYG QGNSYILPTC QRNDLLKDDR NPMLSISKQK IKNIWSKFKN
     NTCKEHNVNR ISESKNNNYV HKMEIMNIPK KGLGNEYYNY PYDNNNNNNN INNNNNNINN
     NSNSNNIINN KECINKPIIY MNHINNNNMD KQMRPKCIFN WKIAKKSLMK MLHSAHNFYF
     NGVKYSDWKF TCIPTLGFSK SSNRVQQMYR AFVVPKDSNV KKEVKLFIKK IPIYIWVKQF
     NLMNEYDGEY VTDGENFVME ATALAFLNEY HPGITPKLYK ILYEPDNKYF NEGLSQKSMY
     NNLNVFNDML SERLKCNVGG NIVIVSEFFN EDILDFIDRR QKKYNMKISN NEKSFILYQC
     LKLLIRLHDA GLSHLDLTPE NILISDNYEL RFCDLSKSTP IYTYNLRHIK DMNRLYLFES
     CEPTIAKGAY MPPECWKIYW KYDTMKIKNP LKDLKHITDQ EKRKQFYFDV SNADKFMLGV
     FFFWIWTNGN LWKCSDPLQD EDFFYFVKCD MNFDNFELTK NWPNELKDII KQLLHVEQRK
     KLNLKDLSAH PWWSFKL
//

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