(data stored in SCRATCH zone)

SWISSPROT: C0H4T6_PLAF7

ID   C0H4T6_PLAF7            Unreviewed;       550 AA.
AC   C0H4T6;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 74.
DE   SubName: Full=Protein phosphatase PPM5, putative {ECO:0000313|EMBL:CAX64112.1};
DE            EC=3.1.3.16 {ECO:0000313|EMBL:CAX64112.1};
GN   ORFNames=PF3D7_0810300 {ECO:0000313|EMBL:CAX64112.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64112.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS00882743};
CC   -!- SIMILARITY: Belongs to the PP2C family.
CC       {ECO:0000256|RuleBase:RU003465}.
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DR   EMBL; AL844507; CAX64112.1; -; Genomic_DNA.
DR   RefSeq; XP_002808835.1; XM_002808789.1.
DR   PRIDE; C0H4T6; -.
DR   EnsemblProtists; CAX64112; CAX64112; PF3D7_0810300.
DR   GeneDB; PF3D7_0810300.1:pep; -.
DR   GeneID; 2655471; -.
DR   KEGG; pfa:PF3D7_0810300; -.
DR   EuPathDB; PlasmoDB:PF3D7_0810300; -.
DR   HOGENOM; HOG000280973; -.
DR   InParanoid; C0H4T6; -.
DR   OMA; KELPYMI; -.
DR   Reactome; R-PFA-1169408; ISG15 antiviral mechanism.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0004724; F:magnesium-dependent protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   CDD; cd00143; PP2Cc; 1.
DR   InterPro; IPR015655; PP2C.
DR   InterPro; IPR000222; PP2C_BS.
DR   InterPro; IPR036457; PPM-type_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase_dom.
DR   PANTHER; PTHR13832; PTHR13832; 2.
DR   Pfam; PF00481; PP2C; 1.
DR   SMART; SM00332; PP2Cc; 1.
DR   SUPFAM; SSF81606; SSF81606; 1.
DR   PROSITE; PS01032; PPM_1; 1.
DR   PROSITE; PS51746; PPM_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C0H4T6.
DR   SWISS-2DPAGE; C0H4T6.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Hydrolase {ECO:0000256|RuleBase:RU003465,
KW   ECO:0000256|SAAS:SAAS00927111, ECO:0000313|EMBL:CAX64112.1};
KW   Magnesium {ECO:0000256|SAAS:SAAS00882703};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00882779};
KW   Protein phosphatase {ECO:0000256|RuleBase:RU003465,
KW   ECO:0000256|SAAS:SAAS00927143};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN      131    542       PPM-type phosphatase.
FT                                {ECO:0000259|PROSITE:PS51746}.
FT   COILED       66     98       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   550 AA;  63620 MW;  1CFEB6E7EEB7BEA0 CRC64;
     MGTCISFLKK NSVKEKKNTR RRLSISTKID LPDDTEEIKR SIQELKHNED KFKESSENVT
     TRRISENEVQ EVVEGEENEE EEERRKKLDK KKRSLKNRSS VAGVRASHFQ EDFEKKCVKI
     KGSVEKLHEN GIGYVCRKGL KPESPNQDDF IIITMENLAL YAIFDGHGPY GHDVSNYVQK
     ELPYMIIKNE NFLKNPKEVF TKAFLNIHEN IERTTNAYLD SFTNKNSNNK LHLNSNFVIN
     DQALESMQGY NNYTDSDTNS DDSYDYDDTI EDDEDDEEDD EEDESNDNKD DDHEEEEEEG
     ESNSSIDDEF NKENKKTKKE NDPDVKEEKS LTTRKKKQKK KKMKKRKKRK NKIFFDSTMS
     GTTATIIVHL FKEKKLYVAY VGDSRAVLGK RKNGSKQLSA VELTKDHKPN CAAEKKRILS
     SGGQVMKLEG DIPYRVFIKN KFYPGLAMSR AIGDTIGHQI GIIAEPDFIE VNINEDEDIL
     VLICSDGVWE FISSEEAVNL IYEFGYNNVQ DAVENLARES WDRWLNEEEN IVDDITIQAI
     YLSEKSKYLK
//

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