(data stored in SCRATCH zone)

SWISSPROT: C0H4V8_PLAF7

ID   C0H4V8_PLAF7            Unreviewed;      1223 AA.
AC   C0H4V8;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   08-MAY-2019, entry version 64.
DE   SubName: Full=DNA helicase, putative {ECO:0000313|EMBL:CAX64136.2};
DE            EC=3.6.4.12 {ECO:0000313|EMBL:CAX64136.2};
GN   ORFNames=PF3D7_0818700 {ECO:0000313|EMBL:CAX64136.2};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64136.2, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAX64136.2; -; Genomic_DNA.
DR   PRIDE; C0H4V8; -.
DR   EnsemblProtists; CAX64136; CAX64136; PF3D7_0818700.
DR   GeneDB; PF3D7_0818700.1:pep; -.
DR   EuPathDB; PlasmoDB:PF3D7_0818700; -.
DR   HOGENOM; HOG000282661; -.
DR   InParanoid; C0H4V8; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0043044; P:ATP-dependent chromatin remodeling; IEA:InterPro.
DR   CDD; cd00079; HELICc; 1.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
DR   PRODOM; C0H4V8.
DR   SWISS-2DPAGE; C0H4V8.
KW   ATP-binding {ECO:0000313|EMBL:CAX64136.2};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Helicase {ECO:0000313|EMBL:CAX64136.2};
KW   Hydrolase {ECO:0000313|EMBL:CAX64136.2};
KW   Nucleotide-binding {ECO:0000313|EMBL:CAX64136.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN      220    425       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN     1038   1217       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   COILED       98    125       {ECO:0000256|SAM:Coils}.
FT   COILED      681    701       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1223 AA;  143663 MW;  8629F5CA0F862898 CRC64;
     MDVFEFVDPL RKRKINNNIL DFNKYVYKDK MEVGEEEIEH DEEKTKDDEI INMKKKKKKK
     KKKKLRRLLD SSSSDDNNEN EEISSKKIKI RKLNSDNEDN KLKNNNNEKK KKEKVEDEKQ
     SNDIEILDSY DEDDENQKAE YEYNLNTLYQ CLYISIQIKN RIIDHFTSEK KDKKEELIKE
     FVKGSFRVSN FQANYEDFEK YVDTFHKLKC YQKCGVLWLY VLYKQNKNGI LADEMGLGKT
     AQTCVFLDYM YKTGTIKNKT IIVAPTSLLK NWDNEINMWC PYLRNHKIIY YGSQSERRYL
     AYDIFSSKGS KNNKYFPSNN NDDEDDGVNN NNNNNNNDDG HNNIHLIITS INMLMGKNDV
     SYFRQIKKYD YLIFDEAHFL KNKNSLIYKK LQKKIVFNNK ILLTGSPIQN KTQELTNLLL
     FLMPHIFTET NINNAMQAFI AMYEEEVQTR NKKKKMDEGT TPKLTTFVEE IMKKNETQSN
     NNNNNNNNNN NSNNNSNNSN NNSNNNNNNS NNNNNSSNNI MMDKCSDMCH KLTDDNNSMN
     NNYNIYDIKC DEEVTDGNIK DDNEKDNNVI VSDTNKSIIK NYLIQTIRDD LKQHVELKNK
     EIILLQLIIE PYILRRSKKH VFIDMPKKHS LIIKLPLNNT QLNLYKDEIF SKMQKTFKHL
     EFLETHSSKK ELQKIYAILN KKEIKNEKNN TRVEKKEIQQ NVDKENYQNG HCNNNTNNME
     SADHNVDVDI GHDNVHVHDD DDDDREMDEE TINIEKTDEE NKNSNIVIHK RDDDSNDMDE
     DNIKDDNNSN SNSHNNNNMC EDSTSPTKEV TLNKSKKNQE NNKNNKEVRG KMINASIFIL
     RRICNHPLLH KYYYTVEDIK KISKYFYYNT DQYVDLDLKT VENEFMKISD FDIHLSIKHL
     ISQGDNKLNK YLITKEHILN SSKINHMLSL IKDIRKKKEK VLIFSQFTTF LDIIEEALLY
     EFIYDDSDYM DHIQTIKSSQ SINKNDTICK EENNINVNVF IKEEQNYHDI GKETKRHDDN
     NNNNINDGDE NKFCFKENIK KPNDIYNEDM ENSERTKDTN CEYNKKKKDE DDEEICLTSS
     TLSTSSVGTQ NDAGHQIYVR LDGSTNTIER QKIIKRFSKD ENIFVFLLST KAGGVGLNLI
     AANHVILMDQ DWNPHNDRQA EDRVHRLGQK NEVFIYRLCC KNTIEEAILK CNKAKLHLDQ
     AFGGNNELLQ TALIKDALNA VDI
//

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