(data stored in SCRATCH zone)

SWISSPROT: C0H4W5_PLAF7

ID   C0H4W5_PLAF7            Unreviewed;       918 AA.
AC   C0H4W5;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 2.
DT   11-DEC-2019, entry version 71.
DE   SubName: Full=Protein kinase 1 {ECO:0000313|EMBL:CAX64143.2};
DE            EC=2.7.11.1 {ECO:0000313|EMBL:CAX64143.2};
GN   ORFNames=PF3D7_0821100 {ECO:0000313|EMBL:CAX64143.2};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64143.2, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAX64143.2; -; Genomic_DNA.
DR   EnsemblProtists; CAX64143; CAX64143; PF3D7_0821100.
DR   GeneDB; PF3D7_0821100.1:pep; -.
DR   EuPathDB; PlasmoDB:PF3D7_0821100; -.
DR   InParanoid; C0H4W5; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
DR   GO; GO:0018107; P:peptidyl-threonine phosphorylation; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 3.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
DR   PRODOM; C0H4W5.
DR   SWISS-2DPAGE; C0H4W5.
KW   Kinase {ECO:0000313|EMBL:CAX64143.2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transferase {ECO:0000313|EMBL:CAX64143.2}.
FT   DOMAIN          35..836
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          178..274
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..670
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..664
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   918 AA;  107246 MW;  9B4DD2D618809D38 CRC64;
     MDLIKIYKRN EIIKDYVNIY FDDEKSENSN KNLSYKILHI IGNGVYGVVY KADCLNNCSI
     VALKQTYQKS TRIFKEIEIM KKLKHPNIVK LKHAFYTSTN DGGVYVHMVM EYGNTDLASS
     LYYITLKDSK EFLKDSFDLD NYNYEDYDDN KSEKDMLPND QQKSDFYYYR SLPNQNEEMT
     ADEKSGIHPG NNNMIVQGMI NSNNNNNRDN NGDNNSSNNN SSNNNSSNNN SSNNNSSNNN
     SSNNNSSNNN SSSSSSSSVL NDVHVNNTPS DEDMESCNYI KNNRRINIIN HFKNSFFNEN
     INNICSCHNI SDFIKKSFLN ENQIKIYLYQ LIRATLYLHS LCITHRDIKP QNILIFLNKT
     NKMKTNKTYI NNKKCLICIQ NNFNIQYIMK KKYNNQFNMF EFNNDMKDTR DEICNLDKTS
     DICDMSCDDK ILNGDGISSC HKINNYNNIL YNSHNKSTNE QNYCEEVRNH DHVNDPCYNI
     SNIKNNIHDK NKKENHTIDD DIQGNDNYSL KNEGQDDLQV CKNNDKKKKD LFVQEMQLCD
     KNKYEGSTSP SNDYNKYDKD CYNNNNLMSN HDDCSAKNNL RLKRLVSMTN LNQRNYYMII
     NDNTDKICDK SITYDDDITK KKNKANINKL NIDKSKNDII SENKDTQIAP PNNSNNNNNN
     NCGDDDNFNH DDLPDQQSLD KLYINSLMYK YIKLCDFNTS IKLKENYKYF SYVCSRYYRA
     PELLFGSNYY SQAIDTWSIG CVMGELLLGK PLFLGECASD QLVEIIKILG TPNDEDFLSF
     RSVYKNIKFP DIKPITLEKV IRHNCSKESL DLLSELLQFN PQKRIKLCHA LLHNYFDDIR
     NLKVFQKDIN TFDKYKLPYN TNCFNFTKEE LLHFTIEERK ILIPQHVRQN KSDEVMQYID
     MTPDHFDKLY PNKIHLTC
//

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