(data stored in SCRATCH zone)

SWISSPROT: C0H4W6_PLAF7

ID   C0H4W6_PLAF7            Unreviewed;        80 AA.
AC   C0H4W6;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   11-DEC-2019, entry version 60.
DE   RecName: Full=Protein transport protein Sec61 subunit beta {ECO:0000256|PIRNR:PIRNR006398};
GN   ORFNames=PF3D7_0821800 {ECO:0000313|EMBL:CAX64144.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64144.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- FUNCTION: Necessary for protein translocation in the endoplasmic
CC       reticulum. {ECO:0000256|PIRNR:PIRNR006398}.
CC   -!- SIMILARITY: Belongs to the SEC61-beta family.
CC       {ECO:0000256|PIRNR:PIRNR006398}.
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DR   EMBL; AL844507; CAX64144.1; -; Genomic_DNA.
DR   RefSeq; XP_002808866.1; XM_002808820.1.
DR   SMR; C0H4W6; -.
DR   PRIDE; C0H4W6; -.
DR   EnsemblProtists; CAX64144; CAX64144; PF3D7_0821800.
DR   GeneDB; PF3D7_0821800.1:pep; -.
DR   GeneID; 2655350; -.
DR   KEGG; pfa:PF3D7_0821800; -.
DR   EuPathDB; PlasmoDB:PF3D7_0821800; -.
DR   HOGENOM; HOG000211109; -.
DR   InParanoid; C0H4W6; -.
DR   KO; K09481; -.
DR   OMA; SSTMMKL; -.
DR   PhylomeDB; C0H4W6; -.
DR   Reactome; R-PFA-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0031205; C:endoplasmic reticulum Sec complex; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005784; C:Sec61 translocon complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; ISS:GeneDB.
DR   GO; GO:0031204; P:posttranslational protein targeting to membrane, translocation; IBA:GO_Central.
DR   GO; GO:0006616; P:SRP-dependent cotranslational protein targeting to membrane, translocation; IBA:GO_Central.
DR   InterPro; IPR030671; Sec61-beta/Sbh.
DR   InterPro; IPR016482; SecG/Sec61-beta/Sbh.
DR   PANTHER; PTHR13509; PTHR13509; 1.
DR   Pfam; PF03911; Sec61_beta; 1.
DR   PIRSF; PIRSF006398; Sec61_beta_euk; 1.
PE   3: Inferred from homology;
DR   PRODOM; C0H4W6.
DR   SWISS-2DPAGE; C0H4W6.
KW   Endoplasmic reticulum {ECO:0000256|PIRNR:PIRNR006398};
KW   Membrane {ECO:0000256|PIRNR:PIRNR006398, ECO:0000256|SAM:Phobius};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR006398};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Translocation {ECO:0000256|PIRNR:PIRNR006398};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|PIRNR:PIRNR006398}.
FT   TRANSMEM        59..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..43
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   80 AA;  8630 MW;  775CFAA265262B93 CRC64;
     MNAAPVIVGG MRTPARRRQS NASANGNNSK QRRNSNGNSN SIVKFYGDDS PGFKLTPQTV
     LISTLIFMAS VVILHIISKI
//

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