(data stored in SCRATCH zone)

SWISSPROT: C0H4Y9_PLAF7

ID   C0H4Y9_PLAF7            Unreviewed;        95 AA.
AC   C0H4Y9;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   11-DEC-2019, entry version 69.
DE   RecName: Full=U6 snRNA-associated Sm-like protein LSm8 {ECO:0000256|RuleBase:RU365048};
GN   Name=LSM8 {ECO:0000256|RuleBase:RU365048};
GN   ORFNames=PF3D7_0829300 {ECO:0000313|EMBL:CAX64164.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64164.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5
CC       tri-snRNP complex that is involved in spliceosome assembly, and as
CC       component of the precatalytic spliceosome (spliceosome B complex). The
CC       heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract
CC       of U6 snRNA. {ECO:0000256|RuleBase:RU365048}.
CC   -!- SUBUNIT: LSm subunits form a heteromer with a doughnut shape.
CC       {ECO:0000256|RuleBase:RU365048}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365048}.
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family.
CC       {ECO:0000256|RuleBase:RU365048}.
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DR   EMBL; AL844507; CAX64164.1; -; Genomic_DNA.
DR   RefSeq; XP_002808886.1; XM_002808840.1.
DR   SMR; C0H4Y9; -.
DR   PRIDE; C0H4Y9; -.
DR   EnsemblProtists; CAX64164; CAX64164; PF3D7_0829300.
DR   GeneDB; PF3D7_0829300.1:pep; -.
DR   GeneID; 2655440; -.
DR   KEGG; pfa:PF3D7_0829300; -.
DR   EuPathDB; PlasmoDB:PF3D7_0829300; -.
DR   HOGENOM; HOG000223549; -.
DR   InParanoid; C0H4Y9; -.
DR   KO; K12627; -.
DR   OMA; CHERVYS; -.
DR   PhylomeDB; C0H4Y9; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005732; C:small nucleolar ribonucleoprotein complex; ISS:GeneDB.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IBA:GO_Central.
DR   GO; GO:0005688; C:U6 snRNP; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0017070; F:U6 snRNA binding; ISS:GeneDB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:GeneDB.
DR   GO; GO:0016070; P:RNA metabolic process; IBA:GO_Central.
DR   CDD; cd01727; LSm8; 1.
DR   InterPro; IPR034103; Lsm8.
DR   InterPro; IPR001163; LSM_dom_euk/arc.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
PE   3: Inferred from homology;
DR   PRODOM; C0H4Y9.
DR   SWISS-2DPAGE; C0H4Y9.
KW   mRNA processing {ECO:0000256|RuleBase:RU365048};
KW   mRNA splicing {ECO:0000256|RuleBase:RU365048};
KW   Nucleus {ECO:0000256|RuleBase:RU365048};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Ribonucleoprotein {ECO:0000256|RuleBase:RU365048,
KW   ECO:0000256|SAAS:SAAS00679672};
KW   RNA-binding {ECO:0000256|RuleBase:RU365048};
KW   Spliceosome {ECO:0000256|RuleBase:RU365048}.
FT   DOMAIN          4..71
FT                   /note="Sm"
FT                   /evidence="ECO:0000259|SMART:SM00651"
SQ   SEQUENCE   95 AA;  10874 MW;  7C82C82AE88A33D7 CRC64;
     MSSINIESYL ENEILVITND SRIFTGKLKG FDQTTNIILG NCHERIYKES MEKISLGVYI
     IRGDTVTLIG EIDEDVDKNI LHQKIKPQML KPIVH
//

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