(data stored in ACNUC1104 zone)

SWISSPROT: C0ZWB6_RHOE4

ID   C0ZWB6_RHOE4            Unreviewed;       484 AA.
AC   C0ZWB6;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   SubName: Full=Putative drug resistance efflux protein {ECO:0000313|EMBL:BAH32651.1};
GN   OrderedLocusNames=RER_19430 {ECO:0000313|EMBL:BAH32651.1};
OS   Rhodococcus erythropolis (strain PR4 / NBRC 100887).
OC   Bacteria; Actinobacteria; Corynebacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=234621 {ECO:0000313|EMBL:BAH32651.1, ECO:0000313|Proteomes:UP000002204};
RN   [1] {ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RA   Takarada H., Sekine M., Hosoyama A., Yamada R., Fujisawa T., Omata S.,
RA   Shimizu A., Tsukatani N., Tanikawa S., Fujita N., Harayama S.;
RT   "Comparison of the complete genome sequences of Rhodococcus
RT   erythropolis PR4 and Rhodococcus opacus B4.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAH32651.1, ECO:0000313|Proteomes:UP000002204}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PR4 / NBRC 100887 {ECO:0000313|Proteomes:UP000002204};
RX   PubMed=16423019; DOI=10.1111/j.1462-2920.2005.00899.x;
RA   Sekine M., Tanikawa S., Omata S., Saito M., Fujisawa T., Tsukatani N.,
RA   Tajima T., Sekigawa T., Kosugi H., Matsuo Y., Nishiko R., Imamura K.,
RA   Ito M., Narita H., Tago S., Fujita N., Harayama S.;
RT   "Sequence analysis of three plasmids harboured in Rhodococcus
RT   erythropolis strain PR4.";
RL   Environ. Microbiol. 8:334-346(2006).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000256|SAAS:SAAS00769108}.
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DR   EMBL; AP008957; BAH32651.1; -; Genomic_DNA.
DR   RefSeq; WP_020906941.1; NC_012490.1.
DR   STRING; 234621.RER_19430; -.
DR   EnsemblBacteria; BAH32651; BAH32651; RER_19430.
DR   GeneID; 31541701; -.
DR   KEGG; rer:RER_19430; -.
DR   PATRIC; fig|234621.6.peg.2440; -.
DR   eggNOG; ENOG4105C0R; Bacteria.
DR   eggNOG; ENOG410XNN3; LUCA.
DR   HOGENOM; HOG000239124; -.
DR   OMA; LDIIWRM; -.
DR   BioCyc; RERY234621:GHDE-1966-MONOMER; -.
DR   Proteomes; UP000002204; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR004638; EmrB-like.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00711; efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
DR   PRODOM; C0ZWB6.
DR   SWISS-2DPAGE; C0ZWB6.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00769078};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002204};
KW   Membrane {ECO:0000256|SAAS:SAAS00769060, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00769091,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00769070,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00769034}.
FT   TRANSMEM     12     37       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     49     69       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     81    100       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    167    189       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    226    241       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    261    283       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    289    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    322    341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    353    380       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    401    418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    430    450       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       15    454       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   484 AA;  49724 MW;  B9668BB83F09E770 CRC64;
     MTEPLALASR RGRWVVAATV LGSSMALLDG TVVNIALPHI GEDLNSGVAG LQWTLSGYTL
     ALASLILLGG ALGDRWGRRR VFVWGTVWFA VASLLCGIAP DITFLVIARI LQGVGAALLT
     PGSLAIISAS LREEDRGAAI GLWSGLGGVA GAIGPLFGGW LVEVAGWRSV FLLNIPLAIV
     VVWAAVRHVP ESRDPHPPEH LDVVGSACAV VGLGALTYGL IEVNPIVGLV GVLALCLFVV
     VERRSPSALV PPSLFRSRMF VAANLVTLAV YAALGGVFFL LVLQLQLVAG YSPVAAGVAT
     VPITLALLLL SSRAGSYAQT HGPRLPMTVG PAVAAVGLVL MTRIGPDASY LTVVLPGVLV
     FGLGLAVMVA PLTAAVLGSV PVEQSGIASG VNNAVARTSQ LLAVAALPAL VGIDAESLVD
     PSSFSDGFRY AMYICVALLL IGAAIAATLI RTPTVEPVQE SDSVACKPHC DLTGPAVQPN
     PMRD
//

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