(data stored in SCRATCH zone)

SWISSPROT: C1E0R3_MICCC

ID   C1E0R3_MICCC            Unreviewed;       317 AA.
AC   C1E0R3;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   07-JUN-2017, entry version 47.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000256|HAMAP-Rule:MF_03008, ECO:0000256|SAAS:SAAS00338492};
DE            Short=eIF3i {ECO:0000256|HAMAP-Rule:MF_03008};
GN   ORFNames=MICPUN_56609 {ECO:0000313|EMBL:ACO62047.1};
OS   Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS   green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; prasinophytes; Mamiellophyceae;
OC   Mamiellales; Mamiellaceae; Micromonas.
OX   NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO62047.1, ECO:0000313|Proteomes:UP000002009};
RN   [1] {ECO:0000313|EMBL:ACO62047.1, ECO:0000313|Proteomes:UP000002009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX   PubMed=19359590; DOI=10.1126/science.1167222;
RA   Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA   Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA   Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA   Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA   Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W.,
RA   Gready J.E., John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F.,
RA   Moreau H., Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I.,
RA   Piegu B., Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T.,
RA   Zelensky A., Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W.,
RA   Van de Peer Y., Grigoriev I.V.;
RT   "Green evolution and dynamic adaptations revealed by genomes of the
RT   marine picoeukaryotes Micromonas.";
RL   Science 324:268-272(2009).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation
CC       factor 3 (eIF-3) complex, which is involved in protein synthesis
CC       of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi
CC       to the 40S ribosome. The eIF-3 complex specifically targets and
CC       initiates translation of a subset of mRNAs involved in cell
CC       proliferation. {ECO:0000256|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor
CC       3 (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03008,
CC       ECO:0000256|SAAS:SAAS00535901}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family.
CC       {ECO:0000256|HAMAP-Rule:MF_03008, ECO:0000256|SAAS:SAAS00535912}.
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DR   EMBL; CP001324; ACO62047.1; -; Genomic_DNA.
DR   RefSeq; XP_002500789.1; XM_002500743.1.
DR   ProteinModelPortal; C1E0R3; -.
DR   GeneID; 8241536; -.
DR   KEGG; mis:MICPUN_56609; -.
DR   HOGENOM; HOG000231322; -.
DR   InParanoid; C1E0R3; -.
DR   KO; K03246; -.
DR   Proteomes; UP000002009; Chromosome 3.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-HAMAP.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-HAMAP.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006446; P:regulation of translational initiation; IEA:UniProtKB-HAMAP.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
DR   PRODOM; C1E0R3.
DR   SWISS-2DPAGE; C1E0R3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002009};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03008,
KW   ECO:0000256|SAAS:SAAS00003569};
KW   Initiation factor {ECO:0000256|HAMAP-Rule:MF_03008,
KW   ECO:0000256|SAAS:SAAS00003557};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03008,
KW   ECO:0000256|SAAS:SAAS00003559};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW   Repeat {ECO:0000256|SAAS:SAAS00723881};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221,
KW   ECO:0000256|SAAS:SAAS00723873}.
FT   DOMAIN       13    317       WD_REPEATS_REGION. {ECO:0000259|PROSITE:
FT                                PS50294}.
FT   REPEAT       43     84       WD. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00221}.
FT   REPEAT      137    178       WD. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00221}.
FT   REPEAT      179    220       WD. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00221}.
FT   REPEAT      276    306       WD. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00221}.
SQ   SEQUENCE   317 AA;  35257 MW;  CBFC8963BB46C6FD CRC64;
     MRPILLKGHE RCYNKEGDLL FTCAKDHHPT LWYSDDGERV GTYIGHNGAV WTCDVTEDSK
     TLVTGSADTT CKMWDTETGT CYFTHQFEQP VRAVALSKGD QHMVISSDPF MGVPAALHIV
     DVAANREEQT NEIKISMSGP EGRINRALWG PLNRTILTGG EDGVIRLWDV ETGKIVHEAN
     DHKKQIQHLS LSVDKTHFIS ASLDKTAKLF DSETLECLKT YAADRPVNAA ILSPILDHII
     LGGGQDAMAV TTTHSKAGKF DSKIFYKIYE EEIGGIRGHF GPINALAWHP DGRSFTSGGE
     DGYVRIHHFD NDYFRIK
//

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