(data stored in SCRATCH zone)

SWISSPROT: C1E1T8_MICCC

ID   C1E1T8_MICCC            Unreviewed;       662 AA.
AC   C1E1T8;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   30-AUG-2017, entry version 42.
DE   RecName: Full=tRNA-dihydrouridine(47) synthase [NAD(P)(+)] {ECO:0000256|RuleBase:RU291113};
DE            EC=1.3.1.- {ECO:0000256|RuleBase:RU291113};
DE   AltName: Full=tRNA-dihydrouridine synthase 3 {ECO:0000256|RuleBase:RU291113};
GN   ORFNames=MICPUN_99494 {ECO:0000313|EMBL:ACO62226.1};
OS   Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS   green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; prasinophytes; Mamiellophyceae;
OC   Mamiellales; Mamiellaceae; Micromonas.
OX   NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO62226.1, ECO:0000313|Proteomes:UP000002009};
RN   [1] {ECO:0000313|EMBL:ACO62226.1, ECO:0000313|Proteomes:UP000002009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX   PubMed=19359590; DOI=10.1126/science.1167222;
RA   Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA   Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA   Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA   Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA   Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W.,
RA   Gready J.E., John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F.,
RA   Moreau H., Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I.,
RA   Piegu B., Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T.,
RA   Zelensky A., Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W.,
RA   Van de Peer Y., Grigoriev I.V.;
RT   "Green evolution and dynamic adaptations revealed by genomes of the
RT   marine picoeukaryotes Micromonas.";
RL   Science 324:268-272(2009).
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|RuleBase:RU291113};
CC   -!- SIMILARITY: Belongs to the dus family. Dus3 subfamily.
CC       {ECO:0000256|RuleBase:RU291113}.
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DR   EMBL; CP001324; ACO62226.1; -; Genomic_DNA.
DR   RefSeq; XP_002500968.1; XM_002500922.1.
DR   ProteinModelPortal; C1E1T8; -.
DR   GeneID; 8241731; -.
DR   KEGG; mis:MICPUN_99494; -.
DR   HOGENOM; HOG000240610; -.
DR   InParanoid; C1E1T8; -.
DR   KO; K05544; -.
DR   Proteomes; UP000002009; Chromosome 3.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0017150; F:tRNA dihydrouridine synthase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd02801; DUS_like_FMN; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   Gene3D; 4.10.1000.10; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR035587; DUS-like_FMN-bd.
DR   InterPro; IPR001269; tRNA_hU_synthase.
DR   InterPro; IPR018517; tRNA_hU_synthase_CS.
DR   InterPro; IPR000571; Znf_CCCH.
DR   PANTHER; PTHR11082; PTHR11082; 1.
DR   Pfam; PF01207; Dus; 1.
DR   Pfam; PF00642; zf-CCCH; 1.
DR   SMART; SM00356; ZnF_C3H1; 2.
DR   SUPFAM; SSF90229; SSF90229; 1.
DR   PROSITE; PS01136; UPF0034; 1.
DR   PROSITE; PS50103; ZF_C3H1; 2.
PE   3: Inferred from homology;
DR   PRODOM; C1E1T8.
DR   SWISS-2DPAGE; C1E1T8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002009};
KW   Flavoprotein {ECO:0000256|RuleBase:RU291113};
KW   FMN {ECO:0000256|RuleBase:RU291113};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723,
KW   ECO:0000256|RuleBase:RU291113};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU291113};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW   tRNA processing {ECO:0000256|RuleBase:RU291113};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00723,
KW   ECO:0000256|RuleBase:RU291113};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723,
KW   ECO:0000256|RuleBase:RU291113}.
FT   DOMAIN       83    110       C3H1-type. {ECO:0000259|PROSITE:PS50103}.
FT   DOMAIN      123    149       C3H1-type. {ECO:0000259|PROSITE:PS50103}.
FT   ZN_FING      83    110       C3H1-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00723}.
FT   ZN_FING     123    149       C3H1-type. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00723}.
SQ   SEQUENCE   662 AA;  73296 MW;  3AC4B74ED2EC9F54 CRC64;
     MSEFTGPDGK PWVPPTADDL IAKGSAAVKT EYLRPVPPLA DTNANVVDDD KAEAGKRGDG
     GVDKKRTGKS RRALAREKKQ ARESGADLCS AFSKGACTFG DKCRYSHNVE SYLRAKQPDL
     PGACPFIAAG KDKCPHGIMC RYLGTHPPVP DTEENKLLPA LTPQTTAELK ERNAAPGVNE
     GVLELPVPES PGGPFGPDDE MNQFCGWLKV RLRKGQVRFD KADAVLKELG VESSWRYGKE
     GDEKLRKKYG EKKDVVDPGE GGGDETREDD DEGGGKRSKV DPDNTAEGVD VKLRPVEKKT
     IDFRGKLYLA PLTTTGNLPF RRICKRYGVD ITCGEMAMVT NLLQGQPAEW ALLRRHPSED
     IFGAQVCGGY SDSMSRCMQL LEDEVVSKGG LDFIDINMGC PIDLVCNKGA GSMLLEKPAR
     MEQLVRASAP LLSCPLTLKT RMGYFDNKRV AHEIIPKMVD WGLAGMTLHG RSRQQRYSRL
     ADWDYINQCA RASPIQLIGN GDVFSYHDYV KNVEGQGVAT CMIARGALIK PWIFTEIKER
     RDWDISATER LDMLKDYAAF GLEHWGADAR GVANTRRFLL EWLSFLHRYV PVGLLERMPV
     GIHQRPPNYV GRSDLETLLS SPNSEDWVKI TTMLLGPTPD NFSFQPKHKS NAYSKESDQV
     QG
//

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