(data stored in SCRATCH zone)

SWISSPROT: C1E223_MICCC

ID   C1E223_MICCC            Unreviewed;       549 AA.
AC   C1E223;
DT   26-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   26-MAY-2009, sequence version 1.
DT   07-JUN-2017, entry version 31.
DE   RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE   AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN   ORFNames=MICPUN_57082 {ECO:0000313|EMBL:ACO61844.1};
OS   Micromonas commoda (strain RCC299 / NOUM17 / CCMP2709) (Picoplanktonic
OS   green alga).
OC   Eukaryota; Viridiplantae; Chlorophyta; prasinophytes; Mamiellophyceae;
OC   Mamiellales; Mamiellaceae; Micromonas.
OX   NCBI_TaxID=296587 {ECO:0000313|EMBL:ACO61844.1, ECO:0000313|Proteomes:UP000002009};
RN   [1] {ECO:0000313|EMBL:ACO61844.1, ECO:0000313|Proteomes:UP000002009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RCC299 / NOUM17 {ECO:0000313|Proteomes:UP000002009};
RX   PubMed=19359590; DOI=10.1126/science.1167222;
RA   Worden A.Z., Lee J.H., Mock T., Rouze P., Simmons M.P., Aerts A.L.,
RA   Allen A.E., Cuvelier M.L., Derelle E., Everett M.V., Foulon E.,
RA   Grimwood J., Gundlach H., Henrissat B., Napoli C., McDonald S.M.,
RA   Parker M.S., Rombauts S., Salamov A., Von Dassow P., Badger J.H.,
RA   Coutinho P.M., Demir E., Dubchak I., Gentemann C., Eikrem W.,
RA   Gready J.E., John U., Lanier W., Lindquist E.A., Lucas S., Mayer K.F.,
RA   Moreau H., Not F., Otillar R., Panaud O., Pangilinan J., Paulsen I.,
RA   Piegu B., Poliakov A., Robbens S., Schmutz J., Toulza E., Wyss T.,
RA   Zelensky A., Zhou K., Armbrust E.V., Bhattacharya D., Goodenough U.W.,
RA   Van de Peer Y., Grigoriev I.V.;
RT   "Green evolution and dynamic adaptations revealed by genomes of the
RT   marine picoeukaryotes Micromonas.";
RL   Science 324:268-272(2009).
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE)
CC       (TC 2.A.66.1) family. {ECO:0000256|RuleBase:RU004914}.
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DR   EMBL; CP001324; ACO61844.1; -; Genomic_DNA.
DR   RefSeq; XP_002500586.1; XM_002500540.1.
DR   GeneID; 8242196; -.
DR   KEGG; mis:MICPUN_57082; -.
DR   HOGENOM; HOG000264986; -.
DR   InParanoid; C1E223; -.
DR   Proteomes; UP000002009; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0015238; F:drug transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 1.
PE   3: Inferred from homology;
DR   PRODOM; C1E223.
DR   SWISS-2DPAGE; C1E223.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002009};
KW   Membrane {ECO:0000256|RuleBase:RU004914};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002009};
KW   Transmembrane {ECO:0000256|RuleBase:RU004914};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    148    169       Helical. {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    181    202       Helical. {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    229    246       Helical. {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    253    275       Helical. {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    281    301       Helical. {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    321    342       Helical. {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    362    384       Helical. {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    405    432       Helical. {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    438    459       Helical. {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    471    493       Helical. {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM    505    523       Helical. {ECO:0000256|RuleBase:RU004914}.
SQ   SEQUENCE   549 AA;  57906 MW;  921DF1A87FCB8FC1 CRC64;
     MVTMLTSCVA ASPIRGEIRR IRRARTAPRS VSVRARKDVD TLVRANLPSR FRSRAIQGPL
     RRGLVHRSPT RIASDAAKDD PEVELSDGVT LDRKAELASV VKFAVPLLAT NIVTPLLTMT
     DTAFVGRCAA DSVIQLAALG VSTPLTDYTV SLAAFIPAGL TNIISNGVAR GEGKESLASK
     TYGALIVSLT LSSIVAIVLN VWPEQLLTML KTPPEVMAAA IEYTRIRSIA MPAAYLTAAA
     YAVLVARKDT TSPLACVCIA AAVNVLLDWI AVGVMGKGAA GAAWATTAAL YAGAVAILGV
     LKRKGFTDAF PWGEFRWKDQ IGPVMAFAGP ITFLVFALLS IYTTLIIMSN ALGVTVSAAH
     RIAGNIFAVA VLCGDPLIQA GQAFMPRYLL PAVPKRVAAR KMAGLLQGVG LFTGFSASTA
     CAFVCLFGGW AFTRDAAVVA QLRAVVVPVC AAVVTNIVSK SMYGVTVAAK QLGFLAAITG
     VGLVGFAGSL WWFKHNLVGS ELYYWMWWVV AGYYGLAIAA IQVRSFGVPG IVKGSFHDDR
     KDTPAPATA
//

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