(data stored in SCRATCH3701 zone)

SWISSPROT: C3T307_ECOLX

ID   C3T307_ECOLX            Unreviewed;       875 AA.
AC   C3T307; A0A0J3YUX2;
DT   16-JUN-2009, integrated into UniProtKB/TrEMBL.
DT   16-JUN-2009, sequence version 1.
DT   11-DEC-2019, entry version 90.
DE   RecName: Full=DNA gyrase subunit A {ECO:0000256|HAMAP-Rule:MF_01897};
DE            EC=5.6.2.2 {ECO:0000256|HAMAP-Rule:MF_01897};
GN   Name=gyrA {ECO:0000256|HAMAP-Rule:MF_01897,
GN   ECO:0000313|EMBL:CTT73282.1};
GN   ORFNames=A6581_14070 {ECO:0000313|EMBL:RCP39310.1}, ARC77_07455
GN   {ECO:0000313|EMBL:AMW42088.1}, AU473_10820
GN   {ECO:0000313|EMBL:APA41349.1}, AW059_07715
GN   {ECO:0000313|EMBL:OTB40831.1}, BHF46_02020
GN   {ECO:0000313|EMBL:OEN38091.1}, BIQ87_13255
GN   {ECO:0000313|EMBL:OWX82608.1}, BIZ41_04785
GN   {ECO:0000313|EMBL:PAQ65276.1}, BON96_18400
GN   {ECO:0000313|EMBL:TFA67029.1}, BTQ04_01605
GN   {ECO:0000313|EMBL:PAU18798.1}, BvCms35BK_02749
GN   {ECO:0000313|EMBL:GCH47759.1}, BvCmsC61A_03648
GN   {ECO:0000313|EMBL:GCJ52213.1}, BvCmsKKP036_03302
GN   {ECO:0000313|EMBL:GDH01687.1}, BvCmsKSNP120_04958
GN   {ECO:0000313|EMBL:GDJ66827.1}, BvCmsSINP022_04212
GN   {ECO:0000313|EMBL:GDS03491.1}, BWP17_05455
GN   {ECO:0000313|EMBL:OOC83311.1}, C7B06_03640
GN   {ECO:0000313|EMBL:PSY81991.1}, C7B07_02580
GN   {ECO:0000313|EMBL:PSZ22255.1}, C7B08_14400
GN   {ECO:0000313|EMBL:PSY92649.1}, C9080_10950
GN   {ECO:0000313|EMBL:TJK94487.1}, C9E67_08960
GN   {ECO:0000313|EMBL:QCL47311.1}, CIJ94_09170
GN   {ECO:0000313|EMBL:OZX95712.1}, CR539_15995
GN   {ECO:0000313|EMBL:AUJ96730.1}, CRE06_14375
GN   {ECO:0000313|EMBL:RFQ85677.1}, CVH05_14910
GN   {ECO:0000313|EMBL:PJG32759.1}, D2F89_18410
GN   {ECO:0000313|EMBL:RIJ80360.1}, D4M06_00610
GN   {ECO:0000313|EMBL:MKB16466.1}, D7K63_13950
GN   {ECO:0000313|EMBL:MML48914.1}, D7K66_12985
GN   {ECO:0000313|EMBL:MME84115.1}, D9D43_01390
GN   {ECO:0000313|EMBL:MGE12256.1}, D9E35_03505
GN   {ECO:0000313|EMBL:MHY86857.1}, D9F17_08900
GN   {ECO:0000313|EMBL:MHZ02547.1}, D9G42_09150
GN   {ECO:0000313|EMBL:MGQ48487.1}, D9H53_24125
GN   {ECO:0000313|EMBL:MIC63814.1}, D9H70_02075
GN   {ECO:0000313|EMBL:MHP13673.1}, D9I87_09955
GN   {ECO:0000313|EMBL:MIA48458.1}, D9J60_18410
GN   {ECO:0000313|EMBL:MMP32870.1}, D9L89_13980
GN   {ECO:0000313|EMBL:MMR46101.1}, D9X97_13320
GN   {ECO:0000313|EMBL:MKX26659.1}, DAH26_01840
GN   {ECO:0000313|EMBL:TGG32056.1}, DAH34_04990
GN   {ECO:0000313|EMBL:TGF73742.1}, DAH49_01840
GN   {ECO:0000313|EMBL:TGF18250.1}, DL455_00610
GN   {ECO:0000313|EMBL:MJD37375.1}, DMI04_09245
GN   {ECO:0000313|EMBL:MJF35927.1}, DNB37_00610
GN   {ECO:0000313|EMBL:MJK79481.1}, DOY56_04860
GN   {ECO:0000313|EMBL:MJR32871.1}, DP258_18280
GN   {ECO:0000313|EMBL:MLN04548.1}, DTL90_23285
GN   {ECO:0000313|EMBL:RCY68451.1}, DTM10_09320
GN   {ECO:0000313|EMBL:RCZ50378.1}, DTM45_08660
GN   {ECO:0000313|EMBL:RDA20335.1}, DU321_21180
GN   {ECO:0000313|EMBL:RRL42268.1}, DXX80_004630
GN   {ECO:0000313|EMBL:TKT34871.1}, E5P37_00870
GN   {ECO:0000313|EMBL:TGI66247.1}, E5S58_04035
GN   {ECO:0000313|EMBL:TGH70212.1}, EB509_07890
GN   {ECO:0000313|EMBL:MDQ89426.1}, EB510_10785
GN   {ECO:0000313|EMBL:MDW74640.1}, EB515_14000
GN   {ECO:0000313|EMBL:MDS18694.1}, ECs3114 {ECO:0000313|EMBL:ACI81091.1},
GN   ED225_14215 {ECO:0000313|EMBL:MEV97192.1}, ED607_12285
GN   {ECO:0000313|EMBL:MFZ54938.1}, ED611_14570
GN   {ECO:0000313|EMBL:MFY60236.1}, ED903_15980
GN   {ECO:0000313|EMBL:MGB99153.1}, ED944_14450
GN   {ECO:0000313|EMBL:MFD99919.1}, EEA45_17815
GN   {ECO:0000313|EMBL:MFC83574.1}, EF173_14520
GN   {ECO:0000313|EMBL:MMW37978.1}, ELV26_17270
GN   {ECO:0000313|EMBL:TFQ05675.1}, ELV28_16580
GN   {ECO:0000313|EMBL:TKJ50510.1}, EPS91_07140
GN   {ECO:0000313|EMBL:RXB82455.1}, EQ830_17295
GN   {ECO:0000313|EMBL:RXA38071.1}, ERS085383_01829
GN   {ECO:0000313|EMBL:CTT73282.1}, ERS085404_01799
GN   {ECO:0000313|EMBL:CTU93273.1}, EVY14_08695
GN   {ECO:0000313|EMBL:RZA91487.1}, EXM29_04820
GN   {ECO:0000313|EMBL:RZN93461.1}, FNJ83_15275
GN   {ECO:0000313|EMBL:QDM71331.1}, FV295_04670
GN   {ECO:0000313|EMBL:TXQ11426.1}, FV438_10840
GN   {ECO:0000313|EMBL:TXR44286.1}, HmCms184_04339
GN   {ECO:0000313|EMBL:GCU37182.1}, HmCmsJML204_01696
GN   {ECO:0000313|EMBL:GDD77711.1}, HMPREF3040_02994
GN   {ECO:0000313|EMBL:KXG97450.1}, JD73_19580
GN   {ECO:0000313|EMBL:KFD75857.1}, MJ49_19640
GN   {ECO:0000313|EMBL:ALL89667.1}, NCTC13127_02085
GN   {ECO:0000313|EMBL:STI64360.1}, NCTC7927_01876
GN   {ECO:0000313|EMBL:STF93130.1}, NCTC8450_03867
GN   {ECO:0000313|EMBL:STE64526.1}, NCTC9050_04930
GN   {ECO:0000313|EMBL:STH89818.1}, NCTC9119_01811
GN   {ECO:0000313|EMBL:STQ49217.1}, NCTC9701_01772
GN   {ECO:0000313|EMBL:STK16410.1}, NCTC9702_01939
GN   {ECO:0000313|EMBL:VED34744.1}, NCTC9777_05123
GN   {ECO:0000313|EMBL:SPX22781.1}, SAMEA3472044_04829
GN   {ECO:0000313|EMBL:SQJ69258.1}, SAMEA3472056_00523
GN   {ECO:0000313|EMBL:SQK80976.1}, SAMEA3472108_00853
GN   {ECO:0000313|EMBL:SQM34021.1}, SAMEA3472147_01359
GN   {ECO:0000313|EMBL:SQP93889.1}, SAMEA3485101_03016
GN   {ECO:0000313|EMBL:SRA08335.1}, SAMEA3485113_00717
GN   {ECO:0000313|EMBL:SRB02771.1}, SAMEA3753097_04491
GN   {ECO:0000313|EMBL:SQR05846.1};
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562 {ECO:0000313|EMBL:ACI81091.1};
RN   [1] {ECO:0000313|EMBL:ACI81091.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=493/89 {ECO:0000313|EMBL:ACI81091.1}, 86-24
RC   {ECO:0000313|EMBL:ACI81092.1}, 87-14 {ECO:0000313|EMBL:ACI81093.1},
RC   TB182A {ECO:0000313|EMBL:ACI81094.1}, and TW14359
RC   {ECO:0000313|EMBL:ACI81095.1};
RX   PubMed=19439656; DOI=10.1073/pnas.0812949106;
RA   Leopold S.R., Magrini V., Holt N.J., Shaikh N., Mardis E.R., Cagno J.,
RA   Ogura Y., Iguchi A., Hayashi T., Mellmann A., Karch H., Besser T.E.,
RA   Sawyer S.A., Whittam T.S., Tarr P.I.;
RT   "A precise reconstruction of the emergence and constrained radiations of
RT   Escherichia coli O157 portrayed by backbone concatenomic analysis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8713-8718(2009).
RN   [2] {ECO:0000313|EMBL:KFD75857.1, ECO:0000313|Proteomes:UP000028651}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=48 {ECO:0000313|EMBL:KFD75857.1,
RC   ECO:0000313|Proteomes:UP000028651};
RA   Nuesch-Inderbinen M.T., Funk J., Cernela N., Tasara T., Klumpp J.,
RA   Schmidt H., Stephan R.;
RT   "Prevalence of subtilase cytotoxin-encoding subAB variants among Shiga
RT   toxin-producing Escherichia coli strains isolated from wild ruminants and
RT   sheep differs from that of cattle and pigs and is predominated by the new
RT   allelic variant subAB2-2.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ALL89667.1, ECO:0000313|Proteomes:UP000065978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2009C-3133 {ECO:0000313|EMBL:ALL89667.1,
RC   ECO:0000313|Proteomes:UP000065978};
RX   PubMed=26679598;
RA   Lindsey R.L., Knipe K., Rowe L., Garcia-Toledo L., Loparev V., Juieng P.,
RA   Trees E., Strockbine N., Stripling D., Gerner-Smidt P.;
RT   "Complete Genome Sequences of Two Shiga Toxin-Producing Escherichia coli
RT   Strains from Serotypes O119:H4 and O165:H25.";
RL   Genome Announc. 3:e01496-15(2015).
RN   [4] {ECO:0000313|EMBL:CTT73282.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=200758_aEPEC {ECO:0000313|EMBL:CTT73282.1}, and
RC   702745_aEPEC {ECO:0000313|EMBL:CTU93273.1};
RA   Rikkerink E.H.A., Fineran P.C.;
RT   "Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the Causal
RT   Agent of Kiwifruit Canker Disease.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Proteomes:UP000043139, ECO:0000313|Proteomes:UP000044658}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=200758_aEPEC {ECO:0000313|Proteomes:UP000044658},
RC   702745_aEPEC {ECO:0000313|Proteomes:UP000043139}, and NCTC9702
RC   {ECO:0000313|EMBL:VED34744.1, ECO:0000313|Proteomes:UP000277930};
RG   Pathogen Informatics;
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:KXG97450.1, ECO:0000313|Proteomes:UP000070450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPH493 {ECO:0000313|EMBL:KXG97450.1,
RC   ECO:0000313|Proteomes:UP000070450};
RA   Wen L., He K., Yang H.;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AMW42088.1, ECO:0000313|Proteomes:UP000076266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=28RC1 {ECO:0000313|EMBL:AMW42088.1,
RC   ECO:0000313|Proteomes:UP000076266};
RA   Baranzoni G.M., Fratamico P., Reichenberger E., Kim G.-H., Breidt F.,
RA   Kay K.;
RT   "Complete Genome Sequences of Escherichia coli O157:H7 strains SRCC 1675
RT   and 28RC.";
RL   Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:OEN38091.1, ECO:0000313|Proteomes:UP000095493}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VL119 {ECO:0000313|EMBL:OEN38091.1,
RC   ECO:0000313|Proteomes:UP000095493};
RA   Blum S.E., Goldstone R.J., Harris S., Leitner G., Smith D.G.;
RT   "Genomic analysis of mastitis and farm-associated E. coli.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:APA41349.1, ECO:0000313|Proteomes:UP000177471}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA20 {ECO:0000313|EMBL:APA41349.1,
RC   ECO:0000313|Proteomes:UP000177471};
RA   Uhlich G.A., Chen C.-Y., Paoli G.;
RT   "E. coli O157:H7 PA20.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:PAU18798.1, ECO:0000313|Proteomes:UP000218692}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=STEC 621S1 {ECO:0000313|EMBL:PAU18798.1,
RC   ECO:0000313|Proteomes:UP000218692};
RA   Ferdous M., Moran-Gilad J., Rossen J.W., Gdalevich M.;
RT   "Real-Time Genomic Investigation Underlying the Public Health Response to a
RT   Shiga Toxin-Producing Escherichia Coli O26:H11 Outbreak in a Nursery.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:OOC83311.1, ECO:0000313|Proteomes:UP000188999}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EDL 933 {ECO:0000313|EMBL:OOC83311.1,
RC   ECO:0000313|Proteomes:UP000188999};
RA   Kozyreva V.K., Truong C.-L., Greninger A.L., Mukhopadhyay R., Crandall J.,
RA   Chaturvedi V.;
RT   "Validation and Implementation of CLIA-Compliant Whole Genome Sequencing
RT   (WGS) in Public Health Laboratory.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:TFA67029.1, ECO:0000313|Proteomes:UP000297344}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2763-16 {ECO:0000313|EMBL:TFA67029.1,
RC   ECO:0000313|Proteomes:UP000297344};
RA   Gumpert H., Hartung Hansen K., Bortolaia V., Jana B., Westh H., Agerso Y.,
RA   Guardabassi L.;
RT   "Whole genome sequencing of CTX-M-14-producing Escherichia coli of animal
RT   and human origin: insights into dissemination of blaCTX-M-14.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:PAQ65276.1, ECO:0000313|Proteomes:UP000215865}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=6770 {ECO:0000313|EMBL:PAQ65276.1,
RC   ECO:0000313|Proteomes:UP000215865};
RA   Saavedra S.Y., Diaz L., Wiesner M., Correa A., Arevalo S.A., Reyes J.,
RA   Hidalgo A.M., De La Cadena E., Perenguez M., Montano L.A., Ardila J.,
RA   Rios R., Ovalle M.V., Diaz P., Porras P., Villegas M.V., Arias C.A.,
RA   Castaneda E., Duarte C.;
RT   "Genomic and Molecular Characterization of Clinical Isolates of
RT   Enterobacteriaceae Harboring mcr-1 in Colombia, 2002-2016.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:OTB40831.1, ECO:0000313|Proteomes:UP000194247}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OLC1000 {ECO:0000313|EMBL:OTB40831.1,
RC   ECO:0000313|Proteomes:UP000194247};
RA   Carrillo C.D., Koziol A.G., Mathews A., Goji N., Lambert D.,
RA   Huszczynski G., Deschenes M., Gauthier M., Amoako K., Blais B.;
RT   "Application of genomics in the determination of verotoxigenic Escherichia
RT   coli toxin subtypes.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:OWX82608.1, ECO:0000313|Proteomes:UP000197281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCJK1770 {ECO:0000313|EMBL:OWX82608.1,
RC   ECO:0000313|Proteomes:UP000197281};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN   [16] {ECO:0000313|EMBL:RFQ85677.1, ECO:0000313|Proteomes:UP000258250}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WI_06BC005151 {ECO:0000313|EMBL:RFQ85677.1,
RC   ECO:0000313|Proteomes:UP000258250};
RA   Harrand S.;
RT   "Produce relevant pathogen strain collection.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:OZX95712.1, ECO:0000313|Proteomes:UP000216687}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC-117-4-3 {ECO:0000313|EMBL:OZX95712.1,
RC   ECO:0000313|Proteomes:UP000216687};
RA   Gumpert H., Kubicek-Sutherland J.Z., Porse A., Karami N., Munck C.,
RA   Linkevicius M., Adlerberth I., Wold A., Andersson D.I., Sommer M.O.A.;
RT   "Transfer and persistence of a multi-drug resistance plasmid in situ of the
RT   infant gut microbiota in the absence of antibiotic treatment.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [18] {ECO:0000313|EMBL:AUJ96730.1, ECO:0000313|Proteomes:UP000234543}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=14EC033 {ECO:0000313|EMBL:AUJ96730.1,
RC   ECO:0000313|Proteomes:UP000234543};
RA   Li B., Wang X.;
RT   "mcr-1 positive E.coli isolates in China.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN   [19] {ECO:0000313|EMBL:PJG32759.1, ECO:0000313|Proteomes:UP000231208}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCJ4029 {ECO:0000313|EMBL:PJG32759.1,
RC   ECO:0000313|Proteomes:UP000231208};
RA   Han C.G.;
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN   [20] {ECO:0000313|Proteomes:UP000297305, ECO:0000313|Proteomes:UP000297363, ECO:0000313|Proteomes:UP000298047}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C306 {ECO:0000313|EMBL:TGG32056.1,
RC   ECO:0000313|Proteomes:UP000297363}, F318 {ECO:0000313|EMBL:TGF73742.1,
RC   ECO:0000313|Proteomes:UP000297305}, and MFS 9
RC   {ECO:0000313|EMBL:TGF18250.1, ECO:0000313|Proteomes:UP000298047};
RA   Baranzoni G.M., Fratamico P.M., Kim G.-H., Funk J.A., Manning S.D.,
RA   Bosilevac J.M.;
RT   "Whole genome sequences of Shiga Toxin-producing Escherichia coli isolated
RT   from swine and other sources.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [21] {ECO:0000313|Proteomes:UP000240448, ECO:0000313|Proteomes:UP000240829, ECO:0000313|Proteomes:UP000241957}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=14017-2 {ECO:0000313|EMBL:PSY92649.1,
RC   ECO:0000313|Proteomes:UP000240448}, 14696-7
RC   {ECO:0000313|EMBL:PSY81991.1, ECO:0000313|Proteomes:UP000240829}, and
RC   15692-2 {ECO:0000313|EMBL:PSZ22255.1,
RC   ECO:0000313|Proteomes:UP000241957};
RA   Whitehouse C.A., Lacher D.W., Mammel M.K., Barnaba T., Lorch J.M.;
RT   "Whole Genome Sequencing of Escherichia coli isolates from wildlife.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [22] {ECO:0000313|Proteomes:UP000298875, ECO:0000313|Proteomes:UP000301113, ECO:0000313|Proteomes:UP000302370}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HUST184 {ECO:0000313|EMBL:GCU37182.1,
RC   ECO:0000313|Proteomes:UP000304731}, JML204
RC   {ECO:0000313|EMBL:GDD77711.1, ECO:0000313|Proteomes:UP000302370},
RC   KK-P036 {ECO:0000313|EMBL:GDH01687.1,
RC   ECO:0000313|Proteomes:UP000301113}, KS-NP120
RC   {ECO:0000313|EMBL:GDJ66827.1, ECO:0000313|Proteomes:UP000298875}, and
RC   SI-NP022 {ECO:0000313|EMBL:GDS03491.1,
RC   ECO:0000313|Proteomes:UP000303212};
RA   Arimizu Y., Ogura Y.;
RT   "Large scale genomics of bovine and human commensal E. coli to reveal the
RT   emerging process of EHEC.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [23] {ECO:0000313|EMBL:QCL47311.1, ECO:0000313|Proteomes:UP000298553}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=143 {ECO:0000313|EMBL:QCL47311.1,
RC   ECO:0000313|Proteomes:UP000298553};
RA   Bono J.L., Arthur T.M.;
RT   "WGA of Escherichia coli O157:H7: comparison of multiple isolates.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [24] {ECO:0000313|Proteomes:UP000250437, ECO:0000313|Proteomes:UP000250650, ECO:0000313|Proteomes:UP000250683}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13127 {ECO:0000313|EMBL:STI64360.1,
RC   ECO:0000313|Proteomes:UP000254180}, NCTC7927
RC   {ECO:0000313|EMBL:STF93130.1, ECO:0000313|Proteomes:UP000254043},
RC   NCTC8450 {ECO:0000313|EMBL:STE64526.1,
RC   ECO:0000313|Proteomes:UP000254538}, NCTC9050
RC   {ECO:0000313|EMBL:STH89818.1, ECO:0000313|Proteomes:UP000254972},
RC   NCTC9119 {ECO:0000313|EMBL:STQ49217.1,
RC   ECO:0000313|Proteomes:UP000254988}, NCTC9701
RC   {ECO:0000313|EMBL:STK16410.1, ECO:0000313|Proteomes:UP000254550},
RC   NCTC9777 {ECO:0000313|EMBL:SPX22781.1,
RC   ECO:0000313|Proteomes:UP000250437}, VREC0287
RC   {ECO:0000313|EMBL:SQM34021.1, ECO:0000313|Proteomes:UP000250695},
RC   VREC0307 {ECO:0000313|EMBL:SQP93889.1,
RC   ECO:0000313|Proteomes:UP000250899}, VREC0374
RC   {ECO:0000313|EMBL:SQR05846.1, ECO:0000313|Proteomes:UP000250683},
RC   VREC0376 {ECO:0000313|EMBL:SQJ69258.1,
RC   ECO:0000313|Proteomes:UP000251822}, VREC0406
RC   {ECO:0000313|EMBL:SQK80976.1, ECO:0000313|Proteomes:UP000250650},
RC   VRES0671 {ECO:0000313|EMBL:SRA08335.1,
RC   ECO:0000313|Proteomes:UP000251419}, and VRES0683
RC   {ECO:0000313|EMBL:SRB02771.1, ECO:0000313|Proteomes:UP000251293};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [25] {ECO:0000313|Proteomes:UP000281225, ECO:0000313|Proteomes:UP000282372, ECO:0000313|Proteomes:UP000282530}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=308727 {ECO:0000313|EMBL:MJF35927.1,
RC   ECO:0000313|Proteomes:UP000282081}, 313266
RC   {ECO:0000313|EMBL:MJD37375.1, ECO:0000313|Proteomes:UP000282284},
RC   389639 {ECO:0000313|EMBL:MJK79481.1,
RC   ECO:0000313|Proteomes:UP000282372}, 418875
RC   {ECO:0000313|EMBL:MJR32871.1, ECO:0000313|Proteomes:UP000282530},
RC   459893 {ECO:0000313|EMBL:MLN04548.1,
RC   ECO:0000313|Proteomes:UP000281225}, and 593596
RC   {ECO:0000313|EMBL:MKB16466.1, ECO:0000313|Proteomes:UP000281445};
RA   Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [26] {ECO:0000313|EMBL:RCP39310.1, ECO:0000313|Proteomes:UP000253108}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MOD1-ECOR37 {ECO:0000313|EMBL:RCP39310.1,
RC   ECO:0000313|Proteomes:UP000253108};
RA   Patel I.R., Gangiredla J., Mammel M.K., Lampel K.A., Elkins C.A.,
RA   Lacher D.W.;
RT   "Draft genome sequences of the Escherichia coli reference (ECOR)
RT   collection.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [27] {ECO:0000313|Proteomes:UP000252138, ECO:0000313|Proteomes:UP000252744, ECO:0000313|Proteomes:UP000253306}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AVC106 {ECO:0000313|EMBL:RDA20335.1,
RC   ECO:0000313|Proteomes:UP000253306}, AVC154
RC   {ECO:0000313|EMBL:RCZ50378.1, ECO:0000313|Proteomes:UP000252138}, and
RC   AVC195 {ECO:0000313|EMBL:RCY68451.1,
RC   ECO:0000313|Proteomes:UP000252744};
RA   Cummins M.L., Reid C.J., Roy Chowdhury P., Bushell R., Esbert N.,
RA   Tivendale K.A., Noormohammadi A.H., Islam S., Marenda M.S., Browning G.F.,
RA   Markham P.F., Djordjevic S.P.;
RT   "Whole Genome Sequence Analysis of Avian Pathogenic E. coli - An Australian
RT   Perspective.";
RL   Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN   [28] {ECO:0000313|EMBL:RIJ80360.1, ECO:0000313|Proteomes:UP000266473}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PS00209 {ECO:0000313|EMBL:RIJ80360.1,
RC   ECO:0000313|Proteomes:UP000266473};
RA   Nwanosike H., Kovac J.;
RL   Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN   [29] {ECO:0000313|Proteomes:UP000267055, ECO:0000313|Proteomes:UP000270084, ECO:0000313|Proteomes:UP000272336}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CVM N17EC0060 {ECO:0000313|EMBL:MGE12256.1,
RC   ECO:0000313|Proteomes:UP000272336}, CVM N17EC0248
RC   {ECO:0000313|EMBL:MHY86857.1, ECO:0000313|Proteomes:UP000270084}, CVM
RC   N17EC0412 {ECO:0000313|EMBL:MHZ02547.1,
RC   ECO:0000313|Proteomes:UP000276933}, CVM N17EC0682
RC   {ECO:0000313|EMBL:MGQ48487.1, ECO:0000313|Proteomes:UP000267055}, CVM
RC   N17EC0910 {ECO:0000313|EMBL:MIC63814.1,
RC   ECO:0000313|Proteomes:UP000279950}, CVM N17EC0946
RC   {ECO:0000313|EMBL:MHP13673.1, ECO:0000313|Proteomes:UP000280118}, CVM
RC   N17EC1181 {ECO:0000313|EMBL:MIA48458.1,
RC   ECO:0000313|Proteomes:UP000281398}, and CVM N17EC1328
RC   {ECO:0000313|EMBL:MMP32870.1, ECO:0000313|Proteomes:UP000279393};
RG   NARMS: The National Antimicrobial Resistance Monitoring System;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [30] {ECO:0000313|Proteomes:UP000277856, ECO:0000313|Proteomes:UP000279027, ECO:0000313|Proteomes:UP000281166}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PNUSAE013007 {ECO:0000313|EMBL:MGB99153.1,
RC   ECO:0000313|Proteomes:UP000281995}, PNUSAE013009
RC   {ECO:0000313|EMBL:MFC83574.1, ECO:0000313|Proteomes:UP000281320},
RC   PNUSAE014897 {ECO:0000313|EMBL:MML48914.1,
RC   ECO:0000313|Proteomes:UP000273320}, PNUSAE017848
RC   {ECO:0000313|EMBL:MEV97192.1, ECO:0000313|Proteomes:UP000282233},
RC   PNUSAE018269 {ECO:0000313|EMBL:MME84115.1,
RC   ECO:0000313|Proteomes:UP000281571}, PNUSAE018306
RC   {ECO:0000313|EMBL:MDW74640.1, ECO:0000313|Proteomes:UP000281166},
RC   PNUSAE019086 {ECO:0000313|EMBL:MMR46101.1,
RC   ECO:0000313|Proteomes:UP000277856}, PNUSAE019230
RC   {ECO:0000313|EMBL:MKX26659.1, ECO:0000313|Proteomes:UP000281625},
RC   PNUSAE019314 {ECO:0000313|EMBL:MMW37978.1,
RC   ECO:0000313|Proteomes:UP000282092}, PNUSAE019329
RC   {ECO:0000313|EMBL:MFY60236.1, ECO:0000313|Proteomes:UP000281456},
RC   PNUSAE019566 {ECO:0000313|EMBL:MDQ89426.1,
RC   ECO:0000313|Proteomes:UP000281718}, PNUSAE019581
RC   {ECO:0000313|EMBL:MDS18694.1, ECO:0000313|Proteomes:UP000281795},
RC   PNUSAE019742 {ECO:0000313|EMBL:MFD99919.1,
RC   ECO:0000313|Proteomes:UP000279027}, and PNUSAE019755
RC   {ECO:0000313|EMBL:MFZ54938.1, ECO:0000313|Proteomes:UP000282463};
RG   PulseNet: The National Subtyping Network for Foodborne Disease Surveillance;
RA   Tarr C.L., Trees E., Katz L.S., Carleton-Romer H.A., Stroika S.,
RA   Kucerova Z., Roache K.F., Sabol A.L., Besser J., Gerner-Smidt P.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [31] {ECO:0000313|EMBL:GCH47759.1, ECO:0000313|Proteomes:UP000303832, ECO:0000313|Proteomes:UP000304105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35-1BK {ECO:0000313|EMBL:GCH47759.1,
RC   ECO:0000313|Proteomes:UP000304105}, and 69-C61-A
RC   {ECO:0000313|EMBL:GCJ52213.1, ECO:0000313|Proteomes:UP000303832};
RA   Arimizu Y., Hayashi T., Ogura Y.;
RT   "Draft genome sequence of commensal E.coli strains.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [32] {ECO:0000313|EMBL:RRL42268.1, ECO:0000313|Proteomes:UP000272662}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMB1727 {ECO:0000313|EMBL:RRL42268.1,
RC   ECO:0000313|Proteomes:UP000272662};
RA   Garretto A., Miller-Ensminger T., Wolfe A.J., Putonti C.;
RT   "E. coli isolates of the female bladder.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [33] {ECO:0000313|EMBL:TJK94487.1, ECO:0000313|Proteomes:UP000306464}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FWSEC0293 {ECO:0000313|EMBL:TJK94487.1,
RC   ECO:0000313|Proteomes:UP000306464};
RA   Tyson S., Peterson C.-L., Olson A., Tyler S., Cabral J., Lynch T., Knox N.,
RA   Van Domselaar G., Graham M.;
RT   "Food and Water Safety Consortium.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN   [34] {ECO:0000313|EMBL:RXB82455.1, ECO:0000313|Proteomes:UP000290547}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=42_rectal {ECO:0000313|EMBL:RXB82455.1,
RC   ECO:0000313|Proteomes:UP000290547};
RA   Potter R., Zou Z., Henderson J., Dantas G.;
RT   "Genomic analysis of febrile catheter-associated UTI E. coli isolates.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [35] {ECO:0000313|EMBL:RXA38071.1, ECO:0000313|Proteomes:UP000289325}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC231 {ECO:0000313|EMBL:RXA38071.1,
RC   ECO:0000313|Proteomes:UP000289325};
RA   Yasir M.;
RT   "Genomic characterization of multidrug resistant E. coli from western Saudi
RT   Arabia.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [36] {ECO:0000313|EMBL:RZA91487.1, ECO:0000313|Proteomes:UP000294012}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ICR003212 {ECO:0000313|EMBL:RZA91487.1,
RC   ECO:0000313|Proteomes:UP000294012};
RA   Cuzon G., Dabos L., Bernabeu S., Lemaitre N., Leyer C., Couve-Deacon E.,
RA   Vidal P., Monpierre L., Le Guillou E., Echaabi A.K., Chainier D.,
RA   Ploy M.-C., Cattoir V., Gaillot O., Fortineau N., Naas T.;
RT   "Undetected carbapenem-resistant Enterobacteriaceae in urine specimens:
RT   results of the French infection-Carbapenem Resistance Evaluation
RT   Surveillance Trial (iCREST-F).";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [37] {ECO:0000313|EMBL:TFQ05675.1, ECO:0000313|Proteomes:UP000297616, ECO:0000313|Proteomes:UP000298694}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=URMC_174 {ECO:0000313|EMBL:TFQ05675.1,
RC   ECO:0000313|Proteomes:UP000297616}, and URMC_26
RC   {ECO:0000313|EMBL:TKJ50510.1, ECO:0000313|Proteomes:UP000298694};
RA   Mostafa H., Pecora N.;
RT   "ESBL Survelliance.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [38] {ECO:0000313|EMBL:RZN93461.1, ECO:0000313|Proteomes:UP000293083}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BA320 {ECO:0000313|EMBL:RZN93461.1,
RC   ECO:0000313|Proteomes:UP000293083};
RA   Martins F.H., Abe C.M., Carvalho E., Nishiyama-Jr M.Y., Kumar A., Xing C.,
RA   Sperandio V., Elias W.P.;
RT   "Role of EspFu protein in atypical enteropathogenic Escherichia coli
RT   pathogenesis.";
RL   Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
RN   [39] {ECO:0000313|EMBL:TGH70212.1, ECO:0000313|Proteomes:UP000297889}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BX1S23 {ECO:0000313|EMBL:TGH70212.1,
RC   ECO:0000313|Proteomes:UP000297889};
RA   Xu A., Liu Y., Niemira B., Scullen O., Boyd G., Ream A., Sommers C.;
RT   "Draft Genome Sequence Of Multi-Drug Resistant Escherichia coli Isolated
RT   From Retail Fresh Herb Products.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [40] {ECO:0000313|EMBL:TKT34871.1, ECO:0000313|Proteomes:UP000256361}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RM10719 {ECO:0000313|EMBL:TKT34871.1,
RC   ECO:0000313|Proteomes:UP000256361};
RA   Quinones B., Lee B.G., Yambao J.C., Silva C.J.;
RT   "Draft Genome Sequences of Escherichia coli O157:H7 Strains Recovered from
RT   a Major Produce-Production Region in California.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [41] {ECO:0000313|EMBL:TGI66247.1, ECO:0000313|Proteomes:UP000297400}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCJK7298 {ECO:0000313|EMBL:TGI66247.1,
RC   ECO:0000313|Proteomes:UP000297400};
RA   Teng L.;
RT   "ESBL E. coli from beef cattle.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [42] {ECO:0000313|EMBL:QDM71331.1, ECO:0000313|Proteomes:UP000315727}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=69 {ECO:0000313|EMBL:QDM71331.1,
RC   ECO:0000313|Proteomes:UP000315727};
RA   Song W.;
RT   "Environmental and genetic determinants of plasmid mobility in pathogenic
RT   Escherichia coli.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN   [43] {ECO:0000313|EMBL:QDM71331.1, ECO:0000313|Proteomes:UP000315727}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=69 {ECO:0000313|EMBL:QDM71331.1,
RC   ECO:0000313|Proteomes:UP000315727};
RA   Bethke J.H., Davidovich A., Cheng L., Lopatkin A.J., Thaden J.T.,
RA   Fowler V.G.Jr., Xiao M., You L.;
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN   [44] {ECO:0000313|EMBL:TXQ11426.1, ECO:0000313|Proteomes:UP000321450, ECO:0000313|Proteomes:UP000321568}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1_18_1 {ECO:0000313|EMBL:TXR44286.1,
RC   ECO:0000313|Proteomes:UP000321568}, and 1_7_1
RC   {ECO:0000313|EMBL:TXQ11426.1, ECO:0000313|Proteomes:UP000321450};
RA   Siniagina M.N., Markelova M.I., Laikov A.V., Boulygina E.A.,
RA   Khusnutdinova D.R., Kharchenko A., Grigoryeva T.V.;
RT   "Whole genome analysis of cultivated E. coli strains isolated from CD
RT   patients and healthy donors.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: A type II topoisomerase that negatively supercoils closed
CC       circular double-stranded (ds) DNA in an ATP-dependent manner to
CC       modulate DNA topology and maintain chromosomes in an underwound state.
CC       Negative supercoiling favors strand separation, and DNA replication,
CC       transcription, recombination and repair, all of which involve strand
CC       separation. Also able to catalyze the interconversion of other
CC       topological isomers of dsDNA rings, including catenanes and knotted
CC       rings. Type II topoisomerases break and join 2 DNA strands
CC       simultaneously in an ATP-dependent manner. {ECO:0000256|HAMAP-
CC       Rule:MF_01897}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|HAMAP-Rule:MF_01897,
CC         ECO:0000256|SAAS:SAAS01218217};
CC   -!- SUBUNIT: Heterotetramer, composed of two GyrA and two GyrB chains. In
CC       the heterotetramer, GyrA contains the active site tyrosine that forms a
CC       transient covalent intermediate with DNA, while GyrB binds cofactors
CC       and catalyzes ATP hydrolysis. {ECO:0000256|HAMAP-Rule:MF_01897}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01897}.
CC   -!- MISCELLANEOUS: Few gyrases are as efficient as E.coli at forming
CC       negative supercoils. Not all organisms have 2 type II topoisomerases;
CC       in organisms with a single type II topoisomerase this enzyme also has
CC       to decatenate newly replicated chromosomes. {ECO:0000256|HAMAP-
CC       Rule:MF_01897}.
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC       {ECO:0000256|HAMAP-Rule:MF_01897}.
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|SAAS:SAAS01062860}.
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DR   EMBL; EU898540; ACI81091.1; -; Genomic_DNA.
DR   EMBL; EU898541; ACI81092.1; -; Genomic_DNA.
DR   EMBL; EU898542; ACI81093.1; -; Genomic_DNA.
DR   EMBL; EU898543; ACI81094.1; -; Genomic_DNA.
DR   EMBL; EU898544; ACI81095.1; -; Genomic_DNA.
DR   EMBL; CP013025; ALL89667.1; -; Genomic_DNA.
DR   EMBL; CP015020; AMW42088.1; -; Genomic_DNA.
DR   EMBL; CP017669; APA41349.1; -; Genomic_DNA.
DR   EMBL; CP024147; AUJ96730.1; -; Genomic_DNA.
DR   EMBL; CYBJ01000008; CTT73282.1; -; Genomic_DNA.
DR   EMBL; CYCH01000008; CTU93273.1; -; Genomic_DNA.
DR   EMBL; BIAN01000084; GCH47759.1; -; Genomic_DNA.
DR   EMBL; BIDZ01000023; GCJ52213.1; -; Genomic_DNA.
DR   EMBL; BFLW01000151; GCU37182.1; -; Genomic_DNA.
DR   EMBL; BFSV01000043; GDD77711.1; -; Genomic_DNA.
DR   EMBL; BFXJ01000100; GDH01687.1; -; Genomic_DNA.
DR   EMBL; BFZM01000079; GDJ66827.1; -; Genomic_DNA.
DR   EMBL; BGHE01000058; GDS03491.1; -; Genomic_DNA.
DR   EMBL; JPQG01000003; KFD75857.1; -; Genomic_DNA.
DR   EMBL; LSNZ01000101; KXG97450.1; -; Genomic_DNA.
DR   EMBL; RLEX01000011; MDQ89426.1; -; Genomic_DNA.
DR   EMBL; RLEV01000011; MDS18694.1; -; Genomic_DNA.
DR   EMBL; RLJY01000012; MDW74640.1; -; Genomic_DNA.
DR   EMBL; RMHX01000013; MEV97192.1; -; Genomic_DNA.
DR   EMBL; RMNN01000033; MFC83574.1; -; Genomic_DNA.
DR   EMBL; RMOH01000011; MFD99919.1; -; Genomic_DNA.
DR   EMBL; RNHG01000013; MFY60236.1; -; Genomic_DNA.
DR   EMBL; RNHF01000024; MFZ54938.1; -; Genomic_DNA.
DR   EMBL; RNJD01000054; MGB99153.1; -; Genomic_DNA.
DR   EMBL; RNLZ01000002; MGE12256.1; -; Genomic_DNA.
DR   EMBL; ROFO01000004; MGQ48487.1; -; Genomic_DNA.
DR   EMBL; RNTP01000003; MHP13673.1; -; Genomic_DNA.
DR   EMBL; ROCK01000002; MHY86857.1; -; Genomic_DNA.
DR   EMBL; RODX01000006; MHZ02547.1; -; Genomic_DNA.
DR   EMBL; ROBI01000015; MIA48458.1; -; Genomic_DNA.
DR   EMBL; RNVT01000088; MIC63814.1; -; Genomic_DNA.
DR   EMBL; RTBW01000001; MJD37375.1; -; Genomic_DNA.
DR   EMBL; RTDX01000008; MJF35927.1; -; Genomic_DNA.
DR   EMBL; RTHS01000001; MJK79481.1; -; Genomic_DNA.
DR   EMBL; RTMR01000004; MJR32871.1; -; Genomic_DNA.
DR   EMBL; RTVT01000001; MKB16466.1; -; Genomic_DNA.
DR   EMBL; RUOF01000012; MKX26659.1; -; Genomic_DNA.
DR   EMBL; RVAY01000035; MLN04548.1; -; Genomic_DNA.
DR   EMBL; RVQE01000013; MME84115.1; -; Genomic_DNA.
DR   EMBL; RVVI01000010; MML48914.1; -; Genomic_DNA.
DR   EMBL; RVYM01000023; MMP32870.1; -; Genomic_DNA.
DR   EMBL; RVZZ01000012; MMR46101.1; -; Genomic_DNA.
DR   EMBL; RWFH01000010; MMW37978.1; -; Genomic_DNA.
DR   EMBL; MIWY01000001; OEN38091.1; -; Genomic_DNA.
DR   EMBL; MTFS01000005; OOC83311.1; -; Genomic_DNA.
DR   EMBL; NEME01000003; OTB40831.1; -; Genomic_DNA.
DR   EMBL; NACG01000043; OWX82608.1; -; Genomic_DNA.
DR   EMBL; NQIT01000022; OZX95712.1; -; Genomic_DNA.
DR   EMBL; MVPG01000015; PAQ65276.1; -; Genomic_DNA.
DR   EMBL; MRVX01000003; PAU18798.1; -; Genomic_DNA.
DR   EMBL; PGUD01000206; PJG32759.1; -; Genomic_DNA.
DR   EMBL; PYQW01000002; PSY81991.1; -; Genomic_DNA.
DR   EMBL; PYQU01000011; PSY92649.1; -; Genomic_DNA.
DR   EMBL; PYQV01000002; PSZ22255.1; -; Genomic_DNA.
DR   EMBL; CP028607; QCL47311.1; -; Genomic_DNA.
DR   EMBL; CP041522; QDM71331.1; -; Genomic_DNA.
DR   EMBL; QOXW01000016; RCP39310.1; -; Genomic_DNA.
DR   EMBL; QOFV01000034; RCY68451.1; -; Genomic_DNA.
DR   EMBL; QOGI01000008; RCZ50378.1; -; Genomic_DNA.
DR   EMBL; QOGV01000004; RDA20335.1; -; Genomic_DNA.
DR   EMBL; PDAQ01000011; RFQ85677.1; -; Genomic_DNA.
DR   EMBL; QXDN01000057; RIJ80360.1; -; Genomic_DNA.
DR   EMBL; RRVG01000033; RRL42268.1; -; Genomic_DNA.
DR   EMBL; SCGH01000026; RXA38071.1; -; Genomic_DNA.
DR   EMBL; SCJA01000009; RXB82455.1; -; Genomic_DNA.
DR   EMBL; SEJY01000030; RZA91487.1; -; Genomic_DNA.
DR   EMBL; SGUH01000010; RZN93461.1; -; Genomic_DNA.
DR   EMBL; UASC01000005; SPX22781.1; -; Genomic_DNA.
DR   EMBL; UCTY01000043; SQJ69258.1; -; Genomic_DNA.
DR   EMBL; UCVA01000002; SQK80976.1; -; Genomic_DNA.
DR   EMBL; UCWC01000002; SQM34021.1; -; Genomic_DNA.
DR   EMBL; UCZG01000008; SQP93889.1; -; Genomic_DNA.
DR   EMBL; UCZZ01000038; SQR05846.1; -; Genomic_DNA.
DR   EMBL; UDHK01000009; SRA08335.1; -; Genomic_DNA.
DR   EMBL; UDIE01000002; SRB02771.1; -; Genomic_DNA.
DR   EMBL; UFZN01000001; STE64526.1; -; Genomic_DNA.
DR   EMBL; UGAK01000003; STF93130.1; -; Genomic_DNA.
DR   EMBL; UGBX01000001; STH89818.1; -; Genomic_DNA.
DR   EMBL; UGCM01000003; STI64360.1; -; Genomic_DNA.
DR   EMBL; UGDO01000002; STK16410.1; -; Genomic_DNA.
DR   EMBL; UGGG01000003; STQ49217.1; -; Genomic_DNA.
DR   EMBL; MTYD01000045; TFA67029.1; -; Genomic_DNA.
DR   EMBL; RZCP01000018; TFQ05675.1; -; Genomic_DNA.
DR   EMBL; QAFU01000001; TGF18250.1; -; Genomic_DNA.
DR   EMBL; QAFF01000006; TGF73742.1; -; Genomic_DNA.
DR   EMBL; QAEX01000001; TGG32056.1; -; Genomic_DNA.
DR   EMBL; SRNB01000002; TGH70212.1; -; Genomic_DNA.
DR   EMBL; SROH01000001; TGI66247.1; -; Genomic_DNA.
DR   EMBL; RRKI01000009; TJK94487.1; -; Genomic_DNA.
DR   EMBL; RZDS01000023; TKJ50510.1; -; Genomic_DNA.
DR   EMBL; QSMR02000002; TKT34871.1; -; Genomic_DNA.
DR   EMBL; VRWX01000005; TXQ11426.1; -; Genomic_DNA.
DR   EMBL; VRYA01000012; TXR44286.1; -; Genomic_DNA.
DR   EMBL; LR134246; VED34744.1; -; Genomic_DNA.
DR   RefSeq; WP_001281251.1; NZ_VTBB01000006.1.
DR   STRING; 362663.ECP_2274; -.
DR   EnsemblBacteria; ALL89667; ALL89667; MJ49_19640.
DR   EnsemblBacteria; AMW42088; AMW42088; ARC77_07455.
DR   EnsemblBacteria; CTT73282; CTT73282; ERS085383_01829.
DR   EnsemblBacteria; CTU93273; CTU93273; ERS085404_01799.
DR   EnsemblBacteria; KFD75857; KFD75857; JD73_19580.
DR   EnsemblBacteria; KME70010; KME70010; SM09_02349.
DR   EnsemblBacteria; KNY70961; KNY70961; AGA26_22420.
DR   EnsemblBacteria; KPO33555; KPO33555; ACU81_22260.
DR   EnsemblBacteria; KUU42103; KUU42103; AWF22_04555.
DR   EnsemblBacteria; KXG97450; KXG97450; HMPREF3040_02994.
DR   EnsemblBacteria; KZJ52451; KZJ52451; AWG90_03985.
DR   EnsemblBacteria; OAO71094; OAO71094; OO96_03540.
DR   EnsemblBacteria; OEG66583; OEG66583; A7H95_16980.
DR   EnsemblBacteria; OEN38091; OEN38091; BHF46_02020.
DR   PATRIC; fig|562.10851.peg.3399; -.
DR   eggNOG; ENOG4105C24; Bacteria.
DR   eggNOG; COG0188; LUCA.
DR   HOGENOM; HOG000076278; -.
DR   BioCyc; GCF_001562855-HMP:HMPREF3040_RS14130-MONOMER; -.
DR   BioCyc; GCF_001865295:AU473_RS10800-MONOMER; -.
DR   Proteomes; UP000028651; Unassembled WGS sequence.
DR   Proteomes; UP000043139; Unassembled WGS sequence.
DR   Proteomes; UP000044658; Unassembled WGS sequence.
DR   Proteomes; UP000065978; Chromosome.
DR   Proteomes; UP000070450; Unassembled WGS sequence.
DR   Proteomes; UP000076266; Chromosome.
DR   Proteomes; UP000095493; Unassembled WGS sequence.
DR   Proteomes; UP000177471; Chromosome.
DR   Proteomes; UP000188999; Unassembled WGS sequence.
DR   Proteomes; UP000194247; Unassembled WGS sequence.
DR   Proteomes; UP000197281; Unassembled WGS sequence.
DR   Proteomes; UP000215865; Unassembled WGS sequence.
DR   Proteomes; UP000216687; Unassembled WGS sequence.
DR   Proteomes; UP000218692; Unassembled WGS sequence.
DR   Proteomes; UP000231208; Unassembled WGS sequence.
DR   Proteomes; UP000234543; Chromosome.
DR   Proteomes; UP000240448; Unassembled WGS sequence.
DR   Proteomes; UP000240829; Unassembled WGS sequence.
DR   Proteomes; UP000241957; Unassembled WGS sequence.
DR   Proteomes; UP000250437; Unassembled WGS sequence.
DR   Proteomes; UP000250650; Unassembled WGS sequence.
DR   Proteomes; UP000250683; Unassembled WGS sequence.
DR   Proteomes; UP000250695; Unassembled WGS sequence.
DR   Proteomes; UP000250899; Unassembled WGS sequence.
DR   Proteomes; UP000251293; Unassembled WGS sequence.
DR   Proteomes; UP000251419; Unassembled WGS sequence.
DR   Proteomes; UP000251822; Unassembled WGS sequence.
DR   Proteomes; UP000252138; Unassembled WGS sequence.
DR   Proteomes; UP000252744; Unassembled WGS sequence.
DR   Proteomes; UP000253108; Unassembled WGS sequence.
DR   Proteomes; UP000253306; Unassembled WGS sequence.
DR   Proteomes; UP000254043; Unassembled WGS sequence.
DR   Proteomes; UP000254180; Unassembled WGS sequence.
DR   Proteomes; UP000254538; Unassembled WGS sequence.
DR   Proteomes; UP000254550; Unassembled WGS sequence.
DR   Proteomes; UP000254972; Unassembled WGS sequence.
DR   Proteomes; UP000254988; Unassembled WGS sequence.
DR   Proteomes; UP000256361; Unassembled WGS sequence.
DR   Proteomes; UP000258250; Unassembled WGS sequence.
DR   Proteomes; UP000266473; Unassembled WGS sequence.
DR   Proteomes; UP000267055; Unassembled WGS sequence.
DR   Proteomes; UP000270084; Unassembled WGS sequence.
DR   Proteomes; UP000272336; Unassembled WGS sequence.
DR   Proteomes; UP000272662; Unassembled WGS sequence.
DR   Proteomes; UP000273320; Unassembled WGS sequence.
DR   Proteomes; UP000276933; Unassembled WGS sequence.
DR   Proteomes; UP000277856; Unassembled WGS sequence.
DR   Proteomes; UP000277930; Chromosome 1.
DR   Proteomes; UP000279027; Unassembled WGS sequence.
DR   Proteomes; UP000279393; Unassembled WGS sequence.
DR   Proteomes; UP000279950; Unassembled WGS sequence.
DR   Proteomes; UP000280118; Unassembled WGS sequence.
DR   Proteomes; UP000281166; Unassembled WGS sequence.
DR   Proteomes; UP000281225; Unassembled WGS sequence.
DR   Proteomes; UP000281320; Unassembled WGS sequence.
DR   Proteomes; UP000281398; Unassembled WGS sequence.
DR   Proteomes; UP000281445; Unassembled WGS sequence.
DR   Proteomes; UP000281456; Unassembled WGS sequence.
DR   Proteomes; UP000281571; Unassembled WGS sequence.
DR   Proteomes; UP000281625; Unassembled WGS sequence.
DR   Proteomes; UP000281718; Unassembled WGS sequence.
DR   Proteomes; UP000281795; Unassembled WGS sequence.
DR   Proteomes; UP000281995; Unassembled WGS sequence.
DR   Proteomes; UP000282081; Unassembled WGS sequence.
DR   Proteomes; UP000282092; Unassembled WGS sequence.
DR   Proteomes; UP000282233; Unassembled WGS sequence.
DR   Proteomes; UP000282284; Unassembled WGS sequence.
DR   Proteomes; UP000282372; Unassembled WGS sequence.
DR   Proteomes; UP000282463; Unassembled WGS sequence.
DR   Proteomes; UP000282530; Unassembled WGS sequence.
DR   Proteomes; UP000289325; Unassembled WGS sequence.
DR   Proteomes; UP000290547; Unassembled WGS sequence.
DR   Proteomes; UP000293083; Unassembled WGS sequence.
DR   Proteomes; UP000294012; Unassembled WGS sequence.
DR   Proteomes; UP000297305; Unassembled WGS sequence.
DR   Proteomes; UP000297344; Unassembled WGS sequence.
DR   Proteomes; UP000297363; Unassembled WGS sequence.
DR   Proteomes; UP000297400; Unassembled WGS sequence.
DR   Proteomes; UP000297616; Unassembled WGS sequence.
DR   Proteomes; UP000297889; Unassembled WGS sequence.
DR   Proteomes; UP000298047; Unassembled WGS sequence.
DR   Proteomes; UP000298553; Chromosome.
DR   Proteomes; UP000298694; Unassembled WGS sequence.
DR   Proteomes; UP000298875; Unassembled WGS sequence.
DR   Proteomes; UP000301113; Unassembled WGS sequence.
DR   Proteomes; UP000302370; Unassembled WGS sequence.
DR   Proteomes; UP000303212; Unassembled WGS sequence.
DR   Proteomes; UP000303832; Unassembled WGS sequence.
DR   Proteomes; UP000304105; Unassembled WGS sequence.
DR   Proteomes; UP000304731; Unassembled WGS sequence.
DR   Proteomes; UP000306464; Unassembled WGS sequence.
DR   Proteomes; UP000315727; Chromosome.
DR   Proteomes; UP000321450; Unassembled WGS sequence.
DR   Proteomes; UP000321568; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006265; P:DNA topological change; IEA:UniProtKB-UniRule.
DR   GO; GO:0006261; P:DNA-dependent DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd00187; TOP4c; 1.
DR   Gene3D; 1.10.268.10; -; 1.
DR   Gene3D; 2.120.10.90; -; 1.
DR   Gene3D; 3.90.199.10; -; 1.
DR   HAMAP; MF_01897; GyrA; 1.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_rep.
DR   InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF101904; SSF101904; 1.
DR   SUPFAM; SSF56719; SSF56719; 1.
PE   3: Inferred from homology;
DR   PRODOM; C3T307.
DR   SWISS-2DPAGE; C3T307.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01897,
KW   ECO:0000256|SAAS:SAAS01062880}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01897};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01897,
KW   ECO:0000256|SAAS:SAAS01062879};
KW   Isomerase {ECO:0000256|HAMAP-Rule:MF_01897, ECO:0000256|SAAS:SAAS00972514,
KW   ECO:0000313|EMBL:CTT73282.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01897,
KW   ECO:0000256|SAAS:SAAS01062871};
KW   Topoisomerase {ECO:0000256|HAMAP-Rule:MF_01897,
KW   ECO:0000256|SAAS:SAAS00974554}.
FT   DOMAIN          11..499
FT                   /note="TOP4c"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          841..875
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          471..491
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   MOTIF           560..566
FT                   /note="GyrA-box"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01897"
FT   COMPBIAS        845..875
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        122
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01897"
SQ   SEQUENCE   875 AA;  96978 MW;  A07E5267A4D364D9 CRC64;
     MSDLAREITP VNIEEELKSS YLDYAMSVIV GRALPDVRDG LKPVHRRVLY AMNVLGNDWN
     KAYKKSARVV GDVIGKYHPH GDSAVYDTIV RMAQPFSLRY MLVDGQGNFG SIDGDSAAAM
     RYTEIRLAKI AHELMADLEK ETVDFVDNYD GTEKIPDVMP TKIPNLLVNG SSGIAVGMAT
     NIPPHNLTEV INGCLAYIDD EDISIEGLME HIPGPDFPTA AIINGRRGIE EAYRTGRGKV
     YIRARAEVEV DAKTGRETII VHEIPYQVNK ARLIEKIAEL VKEKRVEGIS ALRDESDKDG
     MRIVIEVKRD AVGEVVLNNL YSQTQLQVSF GINMVALHHG QPKIMNLKDI IAAFVRHRRE
     VVTRRTIFEL RKARDRAHIL EALAVALANI DPIIELIRHA PTPAEAKTAL VANPWQLGNV
     AAMLERAGDD AARPEWLEPE FGVRDGLYYL TEQQAQAILD LRLQKLTGLE HEKLLDEYKE
     LLDQIAELLR ILGSADRLME VIREELELVR EQFGDKRRTE ITANSADINL EDLITQEDVV
     VTLSHQGYVK YQPLSEYEAQ RRGGKGKSAA RIKEEDFIDR LLVANTHDHI LCFSSRGRVY
     SMKVYQLPEA TRGARGRPIV NLLPLEQDER ITAILPVTEF EEGVKVFMAT ANGTVKKTVL
     TEFNRLRTAG KVAIKLVEGD ELIGVDLTSG EDEVMLFSAE GKVVRFKESS VRAMGCNTTG
     VRGIRLGEGD KVVSLIVPRG DGAILTATQN GYGKRTAVAE YPTKSRATKG VISIKVTERN
     GLVVGAVQVD DCDQIMMITD AGTLVRTRVS EISIVGRNTQ GVILIRTAED ENVVGLQRVA
     EPVDEEDLDT IDGSAAEGDD EIAPEVDVDD EPEEE
//

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