(data stored in SCRATCH zone)

SWISSPROT: C4KF85_SULIK

ID   C4KF85_SULIK            Unreviewed;       437 AA.
AC   C4KF85;
DT   07-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   07-JUL-2009, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   SubName: Full=Isocitrate lyase {ECO:0000313|EMBL:ACR41301.1};
GN   OrderedLocusNames=M164_0683 {ECO:0000313|EMBL:ACR41301.1};
OS   Sulfolobus islandicus (strain M.16.4 / Kamchatka #3).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=426118 {ECO:0000313|EMBL:ACR41301.1, ECO:0000313|Proteomes:UP000001479};
RN   [1] {ECO:0000313|EMBL:ACR41301.1, ECO:0000313|Proteomes:UP000001479}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M.16.4 / Kamchatka #3 {ECO:0000313|Proteomes:UP000001479};
RX   PubMed=19435847; DOI=10.1073/pnas.0808945106;
RA   Reno M.L., Held N.L., Fields C.J., Burke P.V., Whitaker R.J.;
RT   "Biogeography of the Sulfolobus islandicus pan-genome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:8605-8610(2009).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR001362-3};
CC       Note=Can also use Mn(2+) ion. {ECO:0000256|PIRSR:PIRSR001362-3};
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DR   EMBL; CP001402; ACR41301.1; -; Genomic_DNA.
DR   EnsemblBacteria; ACR41301; ACR41301; M164_0683.
DR   KEGG; sid:M164_0683; -.
DR   HOGENOM; HOG000238475; -.
DR   KO; K01637; -.
DR   OMA; LEKDWAE; -.
DR   BioCyc; SISL426118:GI01-698-MONOMER; -.
DR   Proteomes; UP000001479; Chromosome.
DR   GO; GO:0004451; F:isocitrate lyase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   CDD; cd00377; ICL_PEPM; 1.
DR   Gene3D; 3.20.20.60; -; 1.
DR   InterPro; IPR039556; ICL/PEPM.
DR   InterPro; IPR006254; Isocitrate_lyase.
DR   InterPro; IPR018523; Isocitrate_lyase_ph_CS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   PANTHER; PTHR21631; PTHR21631; 1.
DR   Pfam; PF00463; ICL; 2.
DR   PIRSF; PIRSF001362; Isocit_lyase; 1.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   TIGRFAMs; TIGR01346; isocit_lyase; 1.
DR   PROSITE; PS00161; ISOCITRATE_LYASE; 1.
PE   4: Predicted;
DR   PRODOM; C4KF85.
DR   SWISS-2DPAGE; C4KF85.
KW   Complete proteome {ECO:0000313|Proteomes:UP000001479};
KW   Lyase {ECO:0000313|EMBL:ACR41301.1};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR001362-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR001362-3}.
FT   ACT_SITE    191    191       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR001362-1}.
FT   METAL       153    153       Magnesium. {ECO:0000256|PIRSR:
FT                                PIRSR001362-3}.
SQ   SEQUENCE   437 AA;  48923 MW;  E8E7E55F5D0F0AC4 CRC64;
     MNIRDKWSEE EKRLEYEWSE DPRWKGIKRN YKPSDVVKLR GSIRIEYSIA KLASHKLWNL
     LNTEPYIATF GALTGSQAVE MAKAGLKAIY VSGWQVAADN NLSNQTYPDL SLYPSNSVPN
     LVKRLNNALL RADQISWSEG KRDIDYLLPI VADAEAGFGG PIHAFELTKA LIEAGAAGVH
     FEDQLAAEKK CGHLGGKVLI PISAFIRVLN AARLASDVLG VPTILIARTD APNAKYLSND
     VDETDNQFLT GKRTSEGYYE IRGGIEYAIA RGLAYAPYAD LLWFETSKPD LEEARQFAEA
     IHTHYPGKLL AYNLSPSFNW KKFMDDSKIS RFMTELGEMG YKFQFITLAG WHLINYHTFK
     LARAYRNEGM PAYVRLQESE FQAQAEGYTA VSHQREVGTD YFDLVLTIAS GGEASTTAME
     GSTEAEQFVE AKQKVLK
//

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